Kendal solicitor wins place with top law firm

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Kendal solicitor wins place with top law firm

6:50pm Tuesday 31st December 2013 in News

A KENDAL solicitor has won a permanent position at a top law firm after completing a two-year training contract.

Zoe Tremeer-Holme has joined Burnetts family law team after graduating from Liverpool John Moores University with first class honours.

Having completed her Legal Practice Course at the College of Law, Chester, she first joined Burnetts as a trainee in 2011.

Now a fully-qualified solicitor, Zoes role involves advising clients on cohabitation, divorce, separation and issues around children.

She said: During university, Id done placements at other firms, but I knew within a short time of being at Burnetts that this was where I wanted to be.

From the outset it was my hope that Id be offered a permanent job once Id qualified. Family law has been my main interest throughout so Im very pleased to be part of the team.

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Kendal solicitor wins place with top law firm

Newly Discovered Molecular Targets May Treat Difficult Melanomas

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January 1, 2014

redOrbit Staff & Wire Reports Your Universe Online

A recently-published study in the journal Clinical Cancer Research supported by the Stand Up To Cancer (SU2C) charitable foundation has identified new molecular targets which could potentially result in new remedies for difficult-to-treat melanomas.

A team of investigators, including Dr. Jeffrey A. Sosman of the Vanderbilt-Ingram Cancer Center and Dr. William Pao of the Vanderbilt University School of Medicine, found two novel BRAF fusions in skin cancers previously believed to lack molecular targets. Furthermore, they found that melanomas with these fusions might be sensitive to anticancer drugs known as MEK inhibitors.

BRAF genes provide instructions for the creation of a protein that transmits chemical signals from the outside of a cell to its nucleus. It is part of a class of genes known as oncogenes, and if these genes mutate they can cause cells to become cancerous, the US National Library of Medicine explained.

According to Dr. Sosman, approximately 35 percent of all melanomas are currently considered pan-negative, meaning that they lack any previously known driver mutations in the BRAF gene or other potential genetic triggers (including mutations in the NRAS, KIT, GNAQ, and GNA11 genes).

He said that he and his colleagues have been studying patients lacking these driver mutations, searching for potential treatment targets within their tumors. In some forms of cancer, two or more genes fuse erroneously, producing irregular proteins that can effectively serve as the drivers of their cancers.

Performing a sophisticated analysis called targeted next-generation sequencing, it appears that about 8 percent of pan-negative melanomas have BRAF fusions, Dr. Sosman explained in a statement. Our results are important because they obviously suggest that there probably are other, as yet unidentified, molecular changes that make these melanomas susceptible to drugs that are available right now.

Dr. Sosman and Dr. Pao analyzed a pan-negative melanoma sample from one of their patients, and found a fusion between two genes (PAPSS1 and BRAF) which they dubbed PAPSS1-BRAF. They then went on to study melanomas from 51 other patients, including 24 which were pan-negative. In those two-dozen pan-negative samples, they found a second novel BRAF fusion, which they called TRIM24-BRAF.

Following additional research, the doctors and their colleagues found that both of these newly-discovered BRAF fusions activated a pathway in the cancer cells known as the MAPK signaling pathway. They treated these cells with either a BRAF inhibitor (vemurafenib) or an MEK inhibitor (trametinib).

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Newly Discovered Molecular Targets May Treat Difficult Melanomas

New ride shares can get you home safe for cheap

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SAN DIEGO (CBS 8) - The CHP and other law enforcement agencies will be out in full force Tuesday, keeping an eye out for New Year's revelers who choose to drink and drive.

Checkpoints and saturation patrols will be set up around the county, and partiers are being urged to designate a driver.

"Make sure you have a sober driver before you go out. That way you don't have to put yourself in a situation when the night is over that you're getting behind the wheel while you're intoxicated," CHP Officer Tommy Doerr said.

Of course, there is no need to get behind the wheel at all with the number of ride-sharing options now available. High-tech alternatives to hailing a traditional taxi cab include Lyft, Sidecar and Uber.

With these services, customers needing a ride first download the company's app on their smartphone. With Uber, you can choose three different levels of service, from a less-expensive standard sedan to a Pricer SUV for larger crowds. You can see in real time where the closest available Uber drivers are to your location, and with a quick tap, request one of them. You even see who your driver is, and what kind of car they're picking you up in,

Because you upload your credit card info ahead of time, there's no need for cash. You're simply billed later, including the tip.

"You get in, you get out. You don't have to worry about anything," Uber general manager Chris Ballard said.

Although keep in mind the price for an Uber ride fluctuates depending on the demand, so peak request times -- such as just after midnight tonight -- will be a bit pricier.

"If you can wait just a little while longer, keep checking your app as the prices do change dynamically. The later on in the evening as demand goes down, the lower the price is going to be for that ride," Ballard said.

Before you order your ride through Uber, there is a fare estimate feature as part of the app to get an idea of how much you'll be charged at any given time.

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New ride shares can get you home safe for cheap

Medicine Lodge Ski Area offers fun for everyone

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Medicine Lodge Ski Area, located just 11 kilometers west of Bentley on Hwy. 12, offers a great winter outing for the whole family.

The ski hill, run by volunteers, has 13 runs, a main T-bar and two platter lifts.

At Medicine Lodge there is a chance for everyone to enjoy skiing; the beginning skier who is content to glide down the bunny hills or the more advanced skier who is ready to take on a black diamond run.

Gina Williams, secretary of the Medicine Lodge Ski Club said the hill is frequented by families from the area as well as larger centres such as Edmonton and Calgary.

So many families come back every year, she said. Its just a wonderful place for everyone to enjoy.

Unfortunately, even though some loyal skiers return year after year, the little ski hill nestled in the rolling hills between Bentley and Rocky Mountain House sometimes gets forgotten as skiers head to the more well known ski resorts.

Sometimes people seem to forget we are here, said Williams.

About 20 volunteers work at the hill. Only lift attendants are paid.

The hill is open on weekends and throughout some Wolf Creek School holidays.

A snowboard instructor, Brandon Lansall is also on staff.

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Medicine Lodge Ski Area offers fun for everyone

Audio-Digest Foundation Announces the Release of Emergency Medicine Volume 30, Issue 17: Pulmonary Disease

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Glendale, CA (PRWEB) December 31, 2013

Audio-Digest Foundation announces the release of Emergency Medicine Volume 30, Issue 17: Pulmonary Disease.

The goal of this program is to improve the management of asthma, chronic obstructive pulmonary disease (COPD), and pneumonia in the emergency department. After hearing and assimilating this program, the clinician will be better able to:

1. Evaluate and compare various agents for the treatment of asthma. 2. Safely initiate intubation and ventilation in the refractory asthma patient. 3. Utilize appropriate tests to distinguish COPD from other diseases. 4. Recognize the indications for antibiotics in treating acute exacerbations of COPD. 5. Determine classification of risk in the patient with pneumonia.

The original programs were presented by James K. Takayesu, MD, MS, Assistant Professor of Surgery, Harvard Medical School, and Associate Residency Director, Harvard Affiliated Emergency Medicine Residency, Brigham and Womens Hospital and Massachusetts General Hospital, Boston. Sandra M. Schneider, MD, Professor and Chair Emeritus, Department of Emergency Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY.

Audio-Digest Foundation, the largest independent publisher of Continuing Medical Education in the world, records over 10,000 hours of lectures every year in anesthesiology, emergency medicine, family practice, gastroenterology, general surgery, internal medicine, neurology, obstetrics/gynecology, oncology, ophthalmology, orthopaedics, otolaryngology, pediatrics, psychology, and urology, by the leading medical researchers at the top laboratories, universities, and institutions.

Recent researchers have hailed from Harvard, Cedars-Sinai, Mayo Clinic, UCSF, The University of Chicago Pritzker School of Medicine, The University of Kansas Medical Center, The University of California, San Diego, The University of Wisconsin School of Medicine, The University of California, San Francisco, School of Medicine, Johns Hopkins University School of Medicine, and many others.

Out of these cutting-edge programs, Audio-Digest then chooses the most clinically relevant, edits them for clarity, and publishes them either every week or every two weeks.

In addition, Audio-Digest publishes subscription series in conjunction with leading medical societies: DiabetesInsight with The American Diabetes Association, ACCEL with The American College of Cardiology, Continuum Audio with The American Academy of Neurology, and Journal Watch Audio General Medicine with Massachusetts Medical Society.

For 60 years, the global medical community of doctors, nurses, physician assistants, and other medical professionals around the world has subscribed to Audio-Digest specialty series in order to remain current in their specialties as well as to maintain their Continuing Education requirements with the most cutting-edge, independent, and unbiased continuing medical education (CME).

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Audio-Digest Foundation Announces the Release of Emergency Medicine Volume 30, Issue 17: Pulmonary Disease

Loyola Bioethics Institute Study Finds Medical Students Concerned About Becoming Desensitized to Dying Patients

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Newswise MAYWOOD, Ill. The imminent death of a patient is riddled with emotions for a patient and family as well as the medical team. A study based on the reflections of third-year Loyola University Chicago Stritch School of Medicine students is shedding light on the struggle physicians in training often face when trying to control their own emotions while not becoming desensitized to the needs of the dying patient and his or her family.

Medical students are very aware they are undergoing a socialization process by which they become desensitized to the difficult things they see every day in the hospital. They realize this is necessary to control their emotions and focus on caring for the patients. On the other hand, they are very concerned about becoming insensitive to the spiritual, emotional and personal needs of the patient, said Mark Kuczewski, PhD, leader author and director of the Loyola University Chicago Stritch School of Medicine Neiswanger Institute for Bioethics.

The study published in the January issue of Academic Medicine, a peer-reviewed medical journal, focused on a randomized group of Loyola third-year medical students who were asked to write an essay reflecting on their personal experience as part of a team caring for a dying patient. The students were asked to think about patient care, communication, compassionate presence and personal/professional development. The assignment was given two months into their clinical rotation and was to be completed five months later allowing the student to complete five of their required clerkships.

The essays were coded using a multistep process and content-analysis approach. A bioethicist, physician and medical school chaplain independently read and coded the essays looking for emerging themes. The team then met together to compare themes and resolve discrepancies. Four themes emerged from the 68 student responses: communication, compassionate presence, patient care and personal and professional development.

The study found that conveying the prognosis of death to patients was understandably difficultbut not just the manner in which it was conveyed, but also who conveyed it.

Students observed how their teams delivered and explained the prognosis. Conversely they also wrote how teams avoided it, the study reported. Students reported no matter how well a physician communicated a prognosis, families and individual family members absorbed and digested the information in their own manner and at their own pace.

The study also pointed out the importance of the medical team having a compassionate presence beyond routine medical interactions, such sharing interests, conveying affection or continuing to show interest in the patient after treatment had ended.

The study affirmed the importance of the medical care team understanding that a patient is body and soul, acknowledging there needs to be emotional and spiritual support for dying patients and their families.

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Loyola Bioethics Institute Study Finds Medical Students Concerned About Becoming Desensitized to Dying Patients

Loyola bioethics study finds medical students concerned about desensitization to dying patients

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PUBLIC RELEASE DATE:

31-Dec-2013

Contact: Evie Polsley epolsley@lumc.edu 708-417-5100 Loyola University Health System

MAYWOOD, Ill. The imminent death of a patient is riddled with emotions for a patient and family as well as the medical team. A study based on the reflections of third-year Loyola University Chicago Stritch School of Medicine students is shedding light on the struggle physicians in training often face when trying to control their own emotions while not becoming desensitized to the needs of the dying patient and his or her family.

"Medical students are very aware they are undergoing a socialization process by which they become desensitized to the difficult things they see every day in the hospital. They realize this is necessary to control their emotions and focus on caring for the patients. On the other hand, they are very concerned about becoming insensitive to the spiritual, emotional and personal needs of the patient," said Mark Kuczewski, PhD, leader author and director of the Loyola University Chicago Stritch School of Medicine Neiswanger Institute for Bioethics.

The study published in the January issue of Academic Medicine, a peer-reviewed medical journal, focused on a randomized group of Loyola third-year medical students who were asked to write an essay reflecting on their personal experience as part of a team caring for a dying patient. The students were asked to think about patient care, communication, compassionate presence and personal/professional development.

The assignment was given two months into their clinical rotation and was to be completed five months later allowing the student to complete five of their required clerkships.

The essays were coded using a multistep process and content-analysis approach. A bioethicist, physician and medical school chaplain independently read and coded the essays looking for emerging themes. The team then met together to compare themes and resolve discrepancies. Four themes emerged from the 68 student responses: communication, compassionate presence, patient care and personal and professional development.

The study found that conveying the prognosis of death to patients was understandably difficultbut not just the manner in which it was conveyed, but also who conveyed it.

"Students observed how their teams delivered and explained the prognosis. Conversely they also wrote how teams avoided it," the study reported.

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Loyola bioethics study finds medical students concerned about desensitization to dying patients

Stay tuned: Business developments to come to fruition in 2014, beyond

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ERIN MCCRACKEN / COURIER & PRESS Norm Bafunno, president of Toyota Motor Manufacturing, Indiana, high fives team member Belinda Chandler, from quality inspection, as they celebrated the start of production of the all-new 2014 Toyota Highlander in a ceremony at the Toyota plant in Princeton, Ind. earlier this month. The new production line of the Highlander has added an additional $430 million dollars in investment and 600 new jobs to the Princeton plant. The Princeton plant will now start production on three versions of the Highlander, the standard model, a hybrid Highlander and the Kluger, the Australian version of the Highlander.

If you had to come up with a theme for the Tri-State's business and economic stories this year, that theme might be "Stay Tuned." Several big developments this year generated a lot of interest, but wont be fully realized until at least 2014. Among them are Midwest Fertilizers planned $2.4 billion Posey County fertilizer project, Indiana Universitys planned medical school and health education center, and federal health care reform.

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2013 Evansville Courier & Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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Stay tuned: Business developments to come to fruition in 2014, beyond

Mississippi State rips Rice 44-7 in Liberty Bowl

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Home Mail News Sports Finance Weather Games Groups Answers Screen Flickr Mobile More omg! Shine Movies Music TV Health Shopping Travel Autos Homes Yahoo Sports Search Sports Search Web Sign In Mail Help Account Info Help Suggestions Yahoo Score Strip League: NCAAF Arizona vs. Boston Coll. Final 42 ARIZ 19 BC Virginia Tech vs. UCLA Final 12 VT 42 (17) UCLA Rice vs. Mississippi St. Final 7 RICE 44 MS ST Duke vs. Texas A&M Final 48 (24) DUKE 52 (21) TAMU Nebraska vs. Georgia 12:00 PM NEB (22) GA UNLV vs. North Texas 12:00 PM UNLV N TX Wisconsin vs. South Carolina 1:00 PM (19) WIS (9) S CAR Iowa vs. LSU 1:00 PM IOWA (16) LSU Stanford vs. Michigan St. 5:00 PM (5) STAN (4) MI ST UCF vs. Baylor 8:30 PM (15) UCF (6) BAYL Oklahoma vs. Alabama Thu 8:30 PM (11) OKLA (3) ALA Oklahoma St. vs. Missouri Fri 7:30 PM (13) OK ST (8) MIZZ Clemson vs. Ohio St. Fri 8:30 PM (12) CLEM (7) OH ST Vanderbilt vs. Houston Sat 1:00 PM VAND HOUS Towson vs. North Dakota St. Sat 2:00 PM TOWS ND ST Arkansas St. vs. Ball St. Sun 9:00 PM AR ST BALL Auburn vs. Florida St. Mon 8:30 PM (2) AUB (1) FL ST View All

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Mississippi State rips Rice 44-7 in Liberty Bowl