AkesoGenX Corp. Assumes Control of Kanzius Cancer Treatment Technology

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Houston, TX (PRWEB) January 15, 2014

Located in Houston, Texas, AkesoGenX Corp. has acquired and assumed control of the intellectual property and equipment related to the Kanzius Cancer Treatment technology from Therm Med LLC. The AkesoGenX management team envisions taking John Kanziuss patented Noninvasive Radio Wave Cancer Treatment from pre-FDA research through to human clinical trials, and if results are positive, to commercialization in concert with their strategic partners. The true goal is making this state-of-the-art technology available to treat those afflicted with cancer.

Origins The reality of current cancer treatment is nothing short of life changing for thousands of patients and their families annuallyno one understood this better than the late John Kanzius. The mission of AkesoGenX Corp. is to provide an alternative noninvasive cancer therapy, which will allow for an effective treatment for cancer patients while reducing side effects associated with traditional chemotherapies and radiation therapies.

The Team The founding members of AkesoGenX Corp. originate from diverse yet complementary sectors within the medical, science and technology industries and bring years of experience and management expertise. The AkesoGenX management team will provide a solid foundation for the human clinical trials needed for commercialization of this innovative cancer treatment technology.

Dr Steven Curley Renowned cancer specialist Dr. Curley will continue his role as lead researcher, now at Baylor College of Medicine in the Texas Medical Center. As a co-founder of AkesoGenX Corp., Dr. Curley will be focused on the direction and timing of FDA submission.

"I made a promise to my friend John Kanzius in 2008 that I would get his treatment into clinical trials in cancer patients. said Dr. Curley I told Nobel Laureate Professor Richard Smalley in 2005 that I would continue to work combining nano particles with the Kanzius RF field to find an effective, less toxic cancer treatment. I owe an eternal debt of gratitude to the Kanzius Cancer Research Foundation and to people everywhere who have supported the Foundation because this work would not have been possible without your optimism and unflagging support. To the people of Erie, Pennsylvania, Fort Myers, Florida and Sanibel Island, THANK YOU! I am confident this new venture will allow us to move this treatment forward in patients fighting against cancer, and I am excited about the future."

Robert Zavala, CEO Co-founder and CEO of AkesoGenX Corp. Robert will be responsible for developing the strategic direction, mission critical partnerships and overall business operations required to move this innovative-patented technology into human clinical trials. Dr. Curley and Mr. Zavala are honored to lead the efforts toward making this treatment available to those afflicted with cancer. Roberts expertise is within the nano-materials industry and because this cancer treatment is based in part on nano-technology, Roberts experience in that industry will benefit AkesoGenX commercialization efforts.

Im honored to be a part of the team which has been led by Dr. Curley. Said Robert, AkesoGenX is looking forward to fulfilling the dream of the inventor of the technology, the late John Kanzius. Both Dr. Curley and I are grateful for all of the continued support we have received from the Kanzius Family, the Erie, Pennsylvania and Sanibel Island, Florida communities and the Kanzius Cancer Research Foundation.

In a statement released today, Maryann, the widow of John Kanzius said, We at Therm Med are very pleased that the technology invented by my late husband, John Kanzius, is in very capable hands with the scientific and business expertise necessary to take this very worthy project to the next level. We wish AkesoGenX the very best.

AkesoGenX Vision AkesoGenX Corp.s strategic vision is to bring to market significant new nano-diagnostic and nano-therapeutic medical products. The primary goal is to move the Kanzius RF field treatment forward to treat patients with highly lethal and resistant forms of cancer.

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AkesoGenX Corp. Assumes Control of Kanzius Cancer Treatment Technology

UH faculty named fellows of National Academy of Inventors

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Zhifeng Ren, M.D. Anderson chair professor of physics and principal investigator at the Texas Center for Superconductivity, was recruited to UH from Boston College in 2012 and is being honored with the 2014 Edith and Peter ODonnell Award in Science.

A professor is in the midst of making a name for both himself and the UH Department of Physics with his work with his team of researchersin five scientific fields.

Zhifeng Ren, principal investigator at the Texas Center for Superconductivity at UH, was recently awarded the Edith and Peter ODonnell Award in Science from the Academy of Medicine, Engineering & Science in Texas and was named a fellow of the National Academy of Inventors.

Rens innovative research serves as an admirable example of what we are striving to do here at the University of Houston, said President Renu Khator in a statement. This groundbreaking work can be used to improve lives in Texas and around the world. His recognition by the Academy of Medicine, Engineering and Science of Texas is both gratifying and well-deserved.

Ren was awarded for his continuing work in carbon nanotubes,thermoelectrics, hierarchical zinc oxide nano-wires, high temperature superconductivity and molecule delivery and sensing.

You dont want to be a 100-meter dash person, he said. You have to be persistent.

The ODonnell Awards recognize researchers who incorporate the uses of science and technology into society, meeting the highest standards of professional performance and resourcefulness.

As of Nov. 21, Ren has contributed to 300 publications in referred journals.Rens latest publication, Recent progress of half-Heusler for moderate temperaturethermoelectric applications in October 2013, which was published in collaboration with assistant professor of physics Shuo Chen, introduces a method of waste heat recoverythat promises to enhance energy efficiency, reduce greenhouse gas emission andpromote sustainable development.The report highlights using thermoelectric devices that convert heat directly to electricity as an option for waste heat harvesting.

Three other UH faculty members were also named fellows of the NAI with Ren: Rathindra Bose, the vice president of Research and Technology Transfer at UH and vice chancellor for Research and Technology Transfer for theUH System; Dmitri Litvinov, a John and Rebecca Moores Professor in the Cullen College of Engineering;and Venkat Selvamanickam, the M.D. Anderson chair professor of mechanicalengineering and director of the Texas Center for Superconductivitys Applied ResearchHub.

The NAI classifies fellow status as a high professional distinction accorded to academic inventors who have demonstrated innovation in creating or facilitating outstanding inventions that have made a tangible effect on the welfare of society.

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UH faculty named fellows of National Academy of Inventors

Myths of Moore’s Law – CNET News

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Moore's Law is only 11 words long, but it's one of the most misunderstood statements in technology.

The basic rule--which states that the number of transistors on a chip doubles every 24 months--has been the guiding principle of the high-tech industry since it was coined by Intel co-founder Gordon Moore in 1965.

It predicts technological progress and explains why the computer industry has been able consistently to come out with products that are smaller, more powerful and less expensive than their predecessors--a dynamic curve that other industries can't match.

Still, most people manage to mangle the rule, one way or another. Many people, for instance, state that Moore's Law says the number of transistors doubles every 18 months--a time frame never laid down by Moore.

Others claim that Moore came up with it while driving down Highway 101 in Silicon Valley. (He says he came up with it while preparing an article for Electronics magazine.)

Worst of all, many postulate that Moore's Law is in danger of running aground because the world no longer needs more powerful computers.

For example, the magazine The Economist theorized on May 8, that the rule was becoming irrelevant, partly because Google CEO Eric Schmidt said the search company relies on less-than-cutting-edge servers. "The industry is simply too efficient," he said. And Kim Polese, founder of corporate software company Marimba, was one of the software executives who told The New York Times that the rule's force was petering out, because people wanted to spend less time at work and more time with their families.

In a bit of magazine performance art, Red Herring ran a cover story on the death of Moore's Law in February--and subsequently went out of business.

Moore's Law, after all, is not a law of physics. It is merely an uncannily accurate observation on what electrical engineers, when organized properly, can do with silicon. Companies that can keep their tech teams humming will reap profits and power. Those that can't will fade away.

One way to view the rule in action is through the history of the 1GHz chip. Both Advanced Micro Devices and Intel released 1GHz microprocessors during the first week of March 2000. At the time, analysts claimed the chips offered more performance than people needed. In fact, the chips probably still offer more than most consumers need.

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Myths of Moore's Law - CNET News

Team Discovers Key Mechanisms to Inhibit Triple Negative Breast Cancers

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Newswise A team of researchers from the Cleveland Clinic and Case Western Reserve School of Medicine have identified critical complex mechanisms involved in the metastasis of deadly triple negative breast cancers (TNBC). These tumors are extremely difficult to treat, frequently return after remission, and are the most aggressive form of breast cancer in women. The discovery of this critical interaction of mechanisms could be used to develop new life saving treatments to kill metastatic tumors in TNBC.

In previous findings published over the past 10 years, our teams have described key mechanisms in these critical proteins, said Khalid Sossey-Alaoui, PhD, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic. A key component in the deadly metastatic potential of TNBC tumors is that they spread through tissues outside the breast very quickly. The two proteins that we studied, WAVE3 and TGF-, when together, promote tumor aggressiveness.

We found important biological implications, said William Schiemann, PhD, an associate professor, Division of General Medical Sciences-Oncology, Case Western Reserve School of Medicine, and co-leader of the Breast Cancer Program at the Case Comprehensive Cancer Center. For the first time, we uncovered an interplay between the two proteins that can inhibit or suppress TNBC a discovery that has the potential to inhibit proliferations of the tumor.

The next step in the research process is to find a way to deliver inhibitors to the tumor. Using nanoparticles, the Sossey-Alaoui, Schiemann team hope to deliver therapies directly to the site of the tumor and reverse the disease. Their goal is to move this basic research into clinical trials in the next three years.

This finding helps to uncover the complex cascade of events that lead to metastasis, said Stanton Gerson, MD, director of the Case Comprehensive Cancer Center and director of the Seidman Cancer Center at UH Case Medical Center. These studies are part of a broad initiative in breast cancer research through numerous collaborative efforts at the Case Comprehensive Cancer Center. Using a team science approach is the most efficient and productive way to have an impact in cancer.

Metastasis is a complex, multi-stage process in which primary tumor cells invade the surrounding cells, tissues and organs, integrate into blood vessels, and survive and move throughout the body. Metastasis of primary mammary tumors accounts for the vast majority of deaths of breast cancer patients. The five-year survival rate for patients with breast cancer drops precipitously from 98% for individuals with localized disease to 23% for those with metastatic disease.

Research support was provided in part by the National Institutes of Health to W.P.S. (CA129359) and E.F.P. (HL073311 and HL HL096062), and by the Department of Defense to K.S.-A. (BC073783) and to M.A.T.(BC093128). Additional support was provided to W.P.S. and K.S.-A. by pilot funds from the Case Comprehensive Cancer Center (P30 CA043703).

This study appeared in the print addition of Breast Cancer Research and Treatment on November 7, 2013. In addition to K. Sossey-Alaoui and W. P. Schiemann, co-authors on the paper include: M. A. Taylor, M. K. Wendt, Case Comprehensive Cancer Center; G. Davuluri, E. F. Plow, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic; J. G. Parvani, Department of Pathology, Case Western Reserve University.

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Team Discovers Key Mechanisms to Inhibit Triple Negative Breast Cancers

Mind uploading – The Society of Neural Prosthetics and Whole …

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Please Note: Yes, this is the original web site dedicated to "mind uploading" into substrate-independent minds (SIM), and in large part discusses the specific implementation route known as whole brain emulation (WBE). But, if you came here to find up-to-date information then you should probably head to the site of our non-profit organization: carboncopies.org. We have had to prioritize updating of the carboncopies.org site in order to support roadmapping, neworking and event related activities.

We will return to refresh this site and give it new purpose as soon as possible!

Thank you for your attention,

rak@minduploading.org

contacts and members

about the society

faq

NeuralProstheses.org

The first Conference on Advancing Substrate Independent Minds (ASIM-2010), August 16-17, organized by Suzanne Gildert and Randal A. Koene ofcarboncopies.org, satellite to the Singularity Summit in San Francisco.

The Oxford Whole Brain Emulation workshop (the resulting Roadmap)

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Mind Uploading Home Page – ibiblio

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Welcome to the Robots shall inherit the Earth; and they shall be Us... The Mind Uploading home page is dedicated to the putative future process of copying one's mind from the natural substrate of the brain into an artificial one, manufactured by humans. This technology will radically alter society in many ways, as science fiction authors have begun to illustrate. Through this server, explore the science behind the science fiction! Technology Assumption of Materialism Handy Neuroscience Facts Proposed Uploading Procedures Microtome Procedure Nanoreplacement Procedure Moravec Procedure Nondestructive Procedures Timelines Past Developments Current Technology Future Developments Directions for Research Hardware for Uploading Philosophy What Is Life? What Is a Person? Personal Identity: the Central Issue see also the essay by Albert-Jan Brouwer and check out the Personal Identity Forum Policy Duplication Artificial Realities (Policy) Effects Life After Uploading Artificial Realities Artificial Bodies Population & Demographics Ecology Brain Enhancements Business & Travel see also Robin Hanson's Article, "If Uploads Come First" References Glossary (Want to help? Get Involved!) MUHomePage.html . . . . . . . . 8/10/2006 . . . . . . . Joe Strout

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Mind Uploading Home Page - ibiblio

Cloud sourcing: Which remote storage option should you choose?

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We've come a long way from the days of floppy discs or the danger of losing a lifetime's worth of photographs or files when your computer breaks down. It today's hi-tech world it's all about storing in the cloud.

Cloud storage services offer a way to make sure important files are available wherever you are and whatever device you are using, be it a smartphone, tablet, laptop or desktop computer. When something is saved in the cloud it is not only stored on your device, but on a computer in a data centre somewhere else in the world. When you want to access a file you can go online and get it instantly.

The advantages of this kind of storage are numerous. You can take a photo on your smartphone and edit it on your PC; access work documents from home; listen to your music collection wherever you are; or share files with friends without sending them to them. Once a file is saved in the cloud, because you are always accessing the same file any edits are carried over. Another big advantage is that if you lose your phone, or your computer dies, you won't lose all your stuff.

Consumers have plenty of choice when it comes to cloud storage services, with some well-known and some less well-known names to choose from.

Dominic Baliszewski, telecoms expert at broadbandchoices, says Apple devotees may already be using Apple's online storage service, iCloud, without realising it. There are many benefits to the iCloud having all your photos seamlessly downloaded to all your devices is perhaps the most obvious one. iCloud offers 5GB of data storage for free, but bear in mind that if you use your iPhone as your main camera and upload all your pictures, it is fairly easy to burn through 5GB in a short space of time, he says.

iCloud isn't alone in offering some storage for free almost all cloud storage providers give you at least 2GB before they start charging. Google Drive is the most generous, giving users 15GB before they start paying.

So, how much space do you need? Obviously that depends on how many and the type of file you want to save. Storing and backing up documents, from Word, Excel, etc, will not take up much room at all, so a basic package [2GB-15GB] will be more than enough for you, Baliszewski says. However, items like photos take up much more room, and music and movies substantially more a two-hour movie can take up 1GB-2GB.

Calculating roughly how much storage you need will help you avoid paying over the odds, as you can then shop around for the provider that offers the best deal for that amount of space. In most cases you will need to commit to a year's storage in advance and pay either annually or monthly. Bear in mind that if you regularly create or add more files, especially big ones, you'll need more storage in the future. Think about what you will use it for, Baliszewski says. If you want to back up your entire digital life, opt for an allowance of 500GB and above.

Comparing prices isn't always easy, as some cloud providers list prices in US$, some bill you monthly and some yearly, and they offer different amounts of storage. Be aware that the value of packages priced in US$ will change if the exchange rate changes. To make comparison easier we have listed annual subscription charges and converted US$ prices into pounds (at the time of writing, using XE.com).

If you need 100GB of space, Google Drive, Microsoft SkyDrive, or Amazon Cloud Drive are cheapest, all charging between $52 and $60 for an annual subscription. If you need 500GB then PC World Knowhow Cloud Storage is the outright winner, charging $49 for an annual subscription that would cost you 10 times the price with rival Dropbox.

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Cloud sourcing: Which remote storage option should you choose?

Chinese medicine may reduce risk of diabetes

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New research shows Chinese herbal medicine may hold promising solutions for people with prediabetes, reports a study in The Journal of Clinical Endocrinology & Metabolism.

A prediabetes diagnosis indicates that an individual has elevated blood sugar levels, but his or her glucose levels are not high enough to have developed Type 2 diabetes.

Traditional Chinese medicine (TCM) focuses on establishing balance in the body in order to treat disease, according to study author Dr. Chun-Su Yuan, director of the Tang Center for Herbal Medicine Research at the University of Chicago.

Its a more holistic approach, using medicine to change the overall body function instead of very specifically on symptoms and organs [like Western medicine], Yuan, who is also the editor-in-chief of the American Journal of Chinese Medicine, told FoxNews.com.

For this study, researchers combined TCMs traditional principles with modern medicine by identifying herbs that have proven effective in treating people with diabetes.

In a double-blind, randomized, placebo-controlled study, 389 participants with impaired glucose tolerance (a risk factor for Type 2 diabetes) were tested every three months to monitor whether they had developed diabetes or if they had experienced a restoration of normal glucose tolerance (NGT), meaning they were no longer at risk for diabetes.

Half of the participants were treated with a Chinese herbal mixture called Tianqi. Tianqi is a capsule containing 10 Chinese herbal medicines including Astragali Radix and Coptidis Rhizoma, which have been previously shown to improve glucose levels. All subjects received dietary education and were advised to maintain their usual physical fitness routines.

Overall, the study found that Tianqi appeared to reduce the risk of diabetes among study participants by 32.1 percent, compared to the placebo group. At the end of the study, 125 subjects (63.13 percent) in the Tianqi group had achieved normal glucose tolerance, compared to only 89 (46.6 percent) in the placebo group. Among the participants who went on to develop diabetes, 56 subjects (29.32 percent) were in the placebo group, compared to only 36 (18.18 percent) in the Tianqi group.

There were no reported severe adverse side effects from Tianqi.

We are excited about this, Yuan said. Its an advantage that we did not observe bad side effects.

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Chinese medicine may reduce risk of diabetes

Smart Hydrogels Delivers Medicine On Demand

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January 16, 2014

Image Caption: UD researchers have developed a "smart" gel that can deliver medicine on demand in response to force. Credit: University of Delaware

Rebekah Eliason for redOrbit.com Your Universe Online

A new study from the University of Delaware has led to the development of a smart hydrogel that is capable of delivering medicine based on response to mechanical force.

For the last several decades, many hydrogels have been created that release medicine in response to pH, temperature, DNA, light and other stimuli. Xinqiao Jia, UD professor of materials science and engineering and biomedical engineering said, The idea of a smart hydrogel that can release medicine over time is not new. Whats new is our ability to have medicine released in response to force a major challenge for people with osteoarthritis and other wear and tear injuries that compromise a persons ability to perform everyday activities.

According to the Arthritis Foundation, osteoarthritis is a chronic condition which affects approximately 27 million Americans. The disease causes soreness or stiffness of the joints that follows inactivity or overuse along with pain that increases after activity or throughout the day.

In this study, researchers developed a hyaluronic acid-based hydrogel. They theorized that if this material was injected into an injured joint site that the motion of walking or participating in therapeutic exercise would cause accelerated release of the drug inside the hydrogel. This method of delivery would help to reduce inflammation and pain.

In laboratory conditions, the researchers determined that the UD-developed hydrogel effectively releases the encapsulated drugs when it is compressed. Through preliminary cell testing, they were also able to confirm that the released drug molecules show anti-inflammatory activity.

The research team is now working alongside colleagues at Rush University in Chicago to begin tests of the hydrogels in animals. The early findings suggest that the gel is biocompatible. Jia explained this is due to the fact that hyaluronic acid naturally occurs in cartilage, which makes the substance more readily accepted by the body.

She also believes that this new hydrogel could help with more conditions than osteoarthritis, such as ligament tears and other high tension injury areas.

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Cleveland Clinic, CWRU School of Medicine team discovers key mechanisms to inhibit

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PUBLIC RELEASE DATE:

16-Jan-2014

Contact: Christine A. Somosi christine.somosi@case.edu 216-368-6287 Case Western Reserve University

A team of researchers from the Cleveland Clinic and Case Western Reserve School of Medicine have identified critical complex mechanisms involved in the metastasis of deadly "triple negative" breast cancers (TNBC). These tumors are extremely difficult to treat, frequently return after remission, and are the most aggressive form of breast cancer in women. The discovery of this critical interaction of mechanisms could be used to develop new life saving treatments to kill metastatic tumors in TNBC.

"In previous findings published over the past 10 years, our teams have described key mechanisms in these critical proteins," said Khalid Sossey-Alaoui, PhD, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic. "A key component in the deadly metastatic potential of TNBC tumors is that they spread through tissues outside the breast very quickly. The two proteins that we studied, WAVE3 and TGF-, when together, promote tumor aggressiveness."

"We found important biological implications," said William Schiemann, PhD, an associate professor, Division of General Medical Sciences-Oncology, Case Western Reserve School of Medicine, and co-leader of the Breast Cancer Program at the Case Comprehensive Cancer Center. "For the first time, we uncovered an interplay between the two proteins that can inhibit or suppress TNBC a discovery that has the potential to inhibit proliferations of the tumor."

The next step in the research process is to find a way to deliver inhibitors to the tumor. Using nanoparticles, the Sossey-Alaoui, Schiemann team hope to deliver therapies directly to the site of the tumor and reverse the disease. Their goal is to move this basic research into clinical trials in the next three years.

"This finding helps to uncover the complex cascade of events that lead to metastasis, " said Stanton Gerson, MD, director of the Case Comprehensive Cancer Center and director of the Seidman Cancer Center at UH Case Medical Center. "These studies are part of a broad initiative in breast cancer research through numerous collaborative efforts at the Case Comprehensive Cancer Center. Using a team science approach is the most efficient and productive way to have an impact in cancer."

Metastasis is a complex, multi-stage process in which primary tumor cells invade the surrounding cells, tissues and organs, integrate into blood vessels, and survive and move throughout the body. Metastasis of primary mammary tumors accounts for the vast majority of deaths of breast cancer patients. The five-year survival rate for patients with breast cancer drops precipitously from 98% for individuals with localized disease to 23% for those with metastatic disease.

###

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Cleveland Clinic, CWRU School of Medicine team discovers key mechanisms to inhibit

Man poisoned by lead in alternative medicine

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A man in Switzerland developed severe lead poisoning after undergoing an alternative medicine treatment he took pills that he thought contained the hair of a dead Bhutanese priest, but the pills were actually replete with the toxic metal lead, according to a report of his case.

It took the man's doctors a week to find out that their patient was taking these pills, and that his symptoms were signs of lead poisoning. (In developed countries, lead poisoning is rare because lead levels in the environment are controlled.)

"It was a very difficult case. The patient had unspecific symptoms, such as abdominal pain, confusion, constipation, vomiting," said Dr. Omar Kherad, a physician at the Hpital de la Tour in Geneva.

"We did all the normal tests in this case, gastroscopy, CT scan, all the blood tests," Kherad said. "We did not find anything, initially."

The doctors finally asked the patient whether he was taking any traditional remedies, because although he lived in Switzerland, he frequently traveled to Bhutan, where people often use alternative medicine.

The doctors were "very surprised when he finally revealed he was taking these pellets every day for three or four months," Kherad told LiveScience. [14 Oddest Medical Cases]

The doctors then checked the level of lead in the patient's blood, and found it to be at least 100 times higher than what is normally found in people living in Switzerland.

The laboratory tests on the pellets found high levels of lead in the red paint on the pellets, corroborating doctors' guess that the pellets were the source of lead in the man's body. [Image of the pellets]

The doctors who treated the man warned that although lead is no longer widely used in Western countries, physicians should ask their patients whether they are taking alternative medications from countries where high levels of lead can still be found in materials such as paint.

"As a consequence of general globalization in medicine, complementary and alternative medicines are being increasingly used in Western countries as they become more popular and easily available on the Internet," the doctors wrote in their report, published last month in the online journal F1000research.

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Man poisoned by lead in alternative medicine