NASA Instruments on European Comet Spacecraft Begin Countdown

Three NASA science instruments are being prepared for check-out operations aboard the European Space Agency's Rosetta spacecraft, which is set to become the first to orbit a comet and land a probe on its nucleus in November.

Rosetta was reactivated Jan. 20 after a record 957 days in hibernation. U.S. mission managers are scheduled to activate their instruments on the spacecraft in early March and begin science operations with them in August. The instruments are an ultraviolet imaging spectrograph, a microwave thermometer and a plasma analyzer.

"U.S. scientists are delighted the Rosetta mission gives us a chance to examine a comet in a way we've never seen one before -- in orbit around it and as it kicks up in activity," said Claudia Alexander, Rosetta's U.S. project scientist at NASA's Jet Propulsion Laboratory in Pasadena, Calif.

"The NASA suite of instruments will provide puzzle pieces the Rosetta science team as a whole will put together with the other pieces to paint a portrait of how a comet works and what it's made of."

Rosetta's objective is to observe the comet 67P/Churyumov-Gerasimenko up close. By examining the full composition of the comet's nucleus and the ways in which a comet changes, Rosetta will help scientists learn more about the origin and evolution of our solar system and the role comets may have played in seeding Earth with water, and perhaps even life.

The ultraviolet imaging spectrograph, called Alice, will analyze gases in the tail of the comet, as well as the coma, the fuzzy envelope around the nucleus of the comet. The coma develops as a comet approaches the sun. Alice also will measure the rate at which the comet produces water, carbon monoxide and carbon dioxide.

These measurements will provide valuable information about the surface composition of the nucleus. The instrument also will measure the amount of argon present, an important clue about the temperature of the solar system at the time the comet's nucleus originally formed more than 4.6 billion years ago.

The Microwave Instrument for Rosetta Orbiter will identify chemicals on or near the comet's surface and measure the temperature of the chemicals and the dust and ice jetting out from the comet. The instrument also will see the gaseous activity in the tail through coma.

The Ion and Electron Sensor is part of a suite of five instruments to analyze the plasma environment of the comet, particularly the coma. The instrument will measure the charged particles in the sun's outer atmosphere, or solar wind, as they interact with the gas flowing out from the comet while Rosetta is drawing nearer to the comet's nucleus.

NASA also provided part of the electronics package the Double Focusing Mass Spectrometer, which is part of the Swiss-built Rosetta Orbiter Spectrometer for Ion and Neutral Analysis (ROSINA) instrument.

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Lungs may suffer when certain elements go nano

7 hours ago by Linda Fulps Yue-Wern Huang, professor of biological sciences at Missouri S&T.

(Phys.org) Nanoparticles are used in all kinds of applicationselectronics, medicine, cosmetics, even environmental clean-ups. More than 2,800 commercially available applications are now based on nanoparticles, and by 2017, the field is expected to bring in nearly $50 billion worldwide.

But this influx of nanotechnology is not without risks, say researchers at Missouri University of Science and Technology.

"There is an urgent need to investigate the potential impact of nanoparticles on health and the environment," says Yue-Wern Huang, professor of biological sciences at Missouri S&T.

Huang and his colleagues have been systematically studying the effects of transition metal oxide nanoparticles on human lung cells. These nanoparticles are used extensively in optical and recording devices, water purification systems, cosmetics and skin care products, and targeted drug delivery, among other applications.

"In their typical coarse powder form, the toxicity of these substances is not dramatic," says Huang. "But as nanoparticles with diameters of only 16-80 nanometers, the situation changes significantly."

The researchers exposed both healthy and cancerous human lung cells to nanoparticles composed of titanium, chromium, manganese, iron, nickel, copper and zinc compoundstransition metal oxides that are on the fourth row of the periodic table. The researchers discovered that the nanoparticles' toxicity to the cells, or cytotoxicity, increased as they moved right on the periodic table.

"About 80 percent of the cells died in the presence of nanoparticles of copper oxide and zinc oxide," says Huang. "These nanoparticles penetrated the cells and destroyed their membranes. The toxic effects are related to the nanoparticles' surface electrical charge and available docking sites."

Huang says that certain nanoparticles released metal ionscalled ion dissolutionwhich also played a significant role in cell death.

Huang is now working on new research that may help reduce nanoparticles' toxicity and shed light on how nanoparticles interact with cells.

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Lungs may suffer when certain elements go nano

Simulations to enable novel lithographic patterning techniques

27.01.2014 - (idw) Fraunhofer-Gesellschaft

European Research Consortium to Develop Simulation Tools, Materials and Processes to Enable Further Miniaturization of Nano-electronics Advanced simulation models and a computational framework for lithography-integrated directed self-assembly (DSA) of block copolymers will be developed within the European project CoLiSA.MMP. These software tools will aid the research and development of new materials, designs and process flows. By enhancing existing and future lithographic patterning techniques, DSA of block copolymers can help to further extend the impressive development in semiconductor technologies. Cost-efficient technologies for the miniaturization of patterns in semiconductor devices are key to the development of more powerful computers, mobile devices and many other types of consumer and industrial electronics. CoLiSA.MMP combines European expertise in soft matter physics, block copolymer chemistry, lithographic process and computational lithography.

For many technology generations, the miniaturization of semiconductor devices was enabled by evolutionary advancements in optical projection lithography. In the past, this was mainly achieved by the reduction of the wavelength or an increase of the numerical aperture (NA). Today with size requirements close to the physical limits, highly involved methods such as optical resolution enhancement techniques, source and mask optimization (SMO), double patterning and lithography-friendly design are required. Only with the help of these, can the downscaling pace of Moores law be maintained, allowing for technology nodes as small as 22 nanometers. The extension of optical lithography to even smaller dimensions will lead to a drastic increase in costs. Extreme ultraviolet (EUV) lithography, at a wavelength of 13.5 nanometers for example, promises a revival of wavelength-driven scaling. Because of major unresolved obstacles associated with the source power and stability and the mask infrastructure, the introduction of EUV has been repeatedly postponed. Directed self-assembly (DSA) of block copolymers offers an alternative approach to scaling. It employs nanophase separation between covalently bound chemically different monomers. In contrast to traditional, increasingly difficult and expensive optics-driven top-down technologies, DSA uses a cost-efficient material-driven bottom-up technique, permitting structures of 10 nanometers and below.

Two challenges still impede an industry-grade application of DSA: 1st, the host substrate strongly impacts DSA. The resulting pattern formation must be understood and modeled exactly in order to optimize its efficiency and to circumvent defects. 2nd, the specific properties of DSA must be considered early during the design stage. Within CoLiSA.MMP novel material and process models and a computational lithography framework for DSA will be developed. The combination of advanced, tailored atomistic and coarse-grained models and a series of complementary experiments, serves as the foundation for the development of highly efficient reduced models that seamlessly integrate into the lithographic process simulation. The new modeling facilities will be used to establish advanced design flows, which account for both the lithographic generation of guiding patterns and the patterns resulting from DSA. By posing the design problem as an inverse one, lithographically manufacturable guiding patterns and process conditions for given target structures can be precisely predicted and at a very early stage. Computational lithography will be also used to investigate the root causes of DSA-specific defects and to propose strategies to avert or mitigate them.

On November 19 and 20, 2013, Fraunhofer IISB in Erlangen, Germany, hosted the kick-off meeting for the 3-year project, which has a total budget of 4.91 million Euros.

CoLiSA.MMP is funded by the European Union in the 7th Framework Programme, under the ICT project number 619793.

Contact Dr. Andreas Erdmann Fraunhofer IISB Schottkystrasse 10, 91058 Erlangen, Germany Tel. +49-9131-761-258 Fax +49-9131-761-212 info@colisa.eu

Fraunhofer IISB The Fraunhofer Institute for Integrated Systems and Device Technology IISB is one of 66 institutes in the Fraunhofer-Gesellschaft. Here, applied research and development is carried out in micro- and nano-electronics, power electronics and mechatronics. With a staff of 180 employees, the institute is committed to contract research for industry and public authorities.

Fraunhofer IISB is internationally recognized for the development of technology, equipment, and materials for nano-electronics and its work on power electronic systems for energy efficiency, hybrid and electric cars.

In addition to its headquarters in Erlangen, the IISB maintains two branch laboratories in Nuremberg and Freiberg.

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Simulations to enable novel lithographic patterning techniques

Molecular geneticist Zoghbi throws light on enigmatic neurological disorder

It was an encounter with a little girl who suffered from an enigmatic neurological disorder that set molecular geneticist Huda Zoghbi on a journey of unexpected scientific discovery, taking her from the paediatric clinic to a medical laboratory, where she would unravel the genetic origins of a rare and devastating condition Rett Syndrome.

Professor Zoghbi, now Professor of Paediatrics, Neurology, Molecular and Human Genetics and Neuroscience at the Baylor College of Medicine, spoke on Monday of the significance of her days as a clinician when she was able to catch medical clues to the relatively unknown disease, and the promise of a treatment made possible by genome sequencing, which can today help identify the cause of several disorders.

It was 16 years after she met her first patient at the Texas Medical Centre in 1983 that she discovered a genetic mutation linked to Rett Syndrome, which caused a critical reduction of the methyl-CpG-binding protein 2 (MECP2) and affected every part and every function of the brain, Professor Zoghbi said in a lecture A journey from the clinic to the laboratory to understand brain disorders she delivered as part of the Cell Press-TNQ India Distinguished Lectureship Series.

Rett Syndrome, an autism spectrum disorder that primarily affects girls (1 in 10,000), alters no fewer than 2,500 genes, causing learning and memory deficits, motor dysfunction and sometimes convulsions. And curiously, this hereditary condition sets in six to 18 months into the childs life: The girl who would sing along to nursery rhymes and greet her father when he returned from work fell silent at the age of two years. She lost her ability to use her hands and would rarely make eye contact. She could not walk with ease and most strikingly, would wring her hands constantly, she said.

However, the techniques of genome sequencing have transformed diagnosis, allowing us to identify causes of so many disorders, said Professor Zoghbi, whose investigations have provided vital clues to the genetic and molecular mechanisms of other neurological disorders such as Spinocerebellar ataxia type 1 and Huntingtons disease.

We are at a time when we can contemplate therapies, she said, adding studies were under way to find out if an anti-epileptic drug can pharmacologically reverse some of the crippling symptoms. Years of research on mice models revealed that when MECP2 was not at its optimal level it impacted a specific class of neurons (GABAergic neurons), which could become targets for therapy to rescue MECP2 levels and therefore alleviate symptoms, she said.

Professor Zoghbi will deliver her lecture at the Music Academy in Chennai at 4.30 p.m., Wednesday, and at the Teen Murti Auditorium in New Delhi at 4.30 p.m. on Friday.

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Molecular geneticist Zoghbi throws light on enigmatic neurological disorder

Improving the Modern Indian Diet, Today’s Medicine Discovers Ancient Wisdom – Video


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Uma Purighalla, MD talks about Ayurveda and Yoga and how it relates to modern evidence based medicine regarding a whole food plant-based diet. http://www.the...

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Demystifying Medicine 2014 – Itching (pruritus): Mechanisms, Diseases, and Treatment – Video


Demystifying Medicine 2014 - Itching (pruritus): Mechanisms, Diseases, and Treatment
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DAVAO MEDICAL SCHOOL FOUNDATION ADMISSION OPEN FOR MD/MBBS CALL:9952922333-2 – Video


DAVAO MEDICAL SCHOOL FOUNDATION ADMISSION OPEN FOR MD/MBBS CALL:9952922333-2
IDEAL CHOICE FOR INDIAN STUDENTS TO GET FOREIGN MEDICAL STUDIES 3rd largest English Speaking country in the World 50% marks in Physics, Chemistry Biolo...

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DAVAO MEDICAL SCHOOL FOUNDATION ADMISSION OPEN FOR MD/MBBS CALL:9952922333-1 – Video


DAVAO MEDICAL SCHOOL FOUNDATION ADMISSION OPEN FOR MD/MBBS CALL:9952922333-1
IDEAL CHOICE FOR INDIAN STUDENTS TO GET FOREIGN MEDICAL STUDIES 3rd largest English Speaking country in the World 50% marks in Physics, Chemistry Biolo...

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