Neanderthal genes are in you

WASHINGTON Next time you call someone a Neanderthal, better look in a mirror.

Many of the genes that help determine most people's skin and hair are more Neanderthal than not, according to two new studies that look at the DNA fossils hidden in the modern human genome.

About 50,000 years ago, modern day humans migrated out of Africa north to Europe and East Asia and met up with furrow-browed Neanderthals that had been in the colder climates for more than 100,000 years. Some of the two species mated. And then the Neanderthals died off as a species except for what's left inside of us.

Scientists isolated the parts of the non-African modern human genetic blueprint that still contain Neanderthal remnants. Overall, it's barely more than 1 percent, said two studies released Wednesday in the journals Nature and Science.

However, in some places, such as the DNA related to the skin, the genetic instructions are as much as 70 percent Neanderthal and in other places there's virtually nothing from the species that's often portrayed as brutish cavemen.

- University of Washington genome scientist Joshua Akey

The difference between where Neanderthal DNA is plentiful and where it's absent may help scientists understand what in our genome "makes humans human," said University of Washington genome scientist Joshua Akey, lead author of the paper in Science.

Harvard researcher Sriram Sankararaman, the lead author of the Nature study, said the place where Neanderthal DNA seemed to have the most influence in the modern human genome has to do with skin and hair. Akey said those instructions are as much as 70 percent Neanderthal.

"We're more Neanderthal than not in those genes," Akey said.

However, Sankararaman cautions that scientists don't yet know just what the Neanderthal DNA dictates in our skin and hair.

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Neanderthal genes are in you

Neanderthal Genes Found in Modern Human DNA, Studies Find

Neanderthals that have been extinct for 28,000 years live on in human DNA, according to research suggesting the genes may help us better survive cold weather and be linked to some present-day diseases.

The Neanderthal genes make up only about 2 percent to 4 percent of the DNA carried by a given human today, according to a paper published in the journal Science. Even so, it may be linked to the development of our hair and skin, as well as to immune disorders such as Type 2 diabetes, the research found.

New DNA techniques are reshaping knowledge of human evolution just as quickly as theyre sparking the development of medical tests and treatments. Thats allowing scientists to peek into history by comparing modern DNA with the Neanderthal genome, recently reconstructed by scientists using material from the toe bone of a female who lived 50,000 years ago.

Were not as beholden to ancient DNA anymore, said Joshua Akey, an associate professor of genome science at the University of Washington in Seattle, and an author of one of the studies. Rather than excavating bones, we can now excavate DNA from modern individuals.

Akeys study identified the skin and hair traits. A second report yesterday by scientists at Harvard Medical School in Boston and the Broad Institute in Cambridge, Massachusetts, found nine links between Neanderthal DNA and previously identified human genes, some of which affect immune function.

The Neanderthal DNA found in the ancient toe bone was reported in the journal Nature in December. That study suggested inbreeding may have been common for Neanderthals, and may have led to their demise. Earlier studies using less complete genetic profiles determined that Neanderthals probably mated with ancient humans as well.

The latest DNA research supports that conclusion and suggests the Neanderthal genes left behind as a result may have aided humans in adapting to non-African environments, Akey said, adding, Whats striking is you can really look at the distribution of Neanderthal DNA across the entire genome.

Both studies published yesterday identified significant areas within the human genome where no Neanderthal genes appear, more than would be anticipated by chance. That suggests some mutations werent passed on, probably because they didnt help survival.

The shared genes that influence hair and skin traits also influence other things, Akey said. Its possible, for instance, that the Neanderthal genes helped alter pigmentation and moisture retention in humans, helping to increase body warmth in colder climates.

The Harvard study found that genes that are most active in the testes and those in the X chromosome have the least Neanderthal influence, compared to other parts of the genome. The pattern may have been a way for the body to naturally overcome infertility among different species.

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Neanderthal Genes Found in Modern Human DNA, Studies Find

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KentuckyOne’s CEO cites health care reform as reason for layoffs

The recession has come to health care in large part because of the Affordable Care Act and the problems that it presents are not unique to KentuckyOne Health, its CEO said Wednesday.

Ruth Brinkley, president and CEO of KentuckyOne Health, said the layoffs and loss of beds her organization is facing are challenges, but patients should be able to get the medical care they need.

Brinkley spoke to The Herald-Leader's editorial board Wednesday following news this week that KentuckyOne Health, which employs 15,000 people and runs St. Joseph Hospital and St. Joseph East in Lexington, is facing a $218 million deficit and is looking at cutting staff and reducing the number of acute-care beds.

Brinkley declined Wednesday to cite specifics about staff reductions or facility cuts. However, she said that the cuts were not being made "across the board" and that each hospital in the KentuckyOne system was being looked at independently.

"We can't afford to provide every service in every location," she said.

That includes examining duplicate services at big-city providers such as Jewish Hospital & St. Mary's HealthCare and the University of Louisville Hospital in Louisville, which all joined to become KentuckyOne Health more than two years ago, along with smaller hospitals in Berea, London, Mount Sterling, Campbellsville and Bardstown.

The issues facing Kentucky One Health might be challenges to other health care providers in the state, too, said Mike Rust, president of the Kentucky Hospital Association.

"These are challenging times, and our hospitals are all feeling the pressures of declining reimbursements," he said, referring to reimbursements from the federal government for Medicare and Medicaid that are tied to the Affordable Care Act.

Layoffs and reorganizations are happening across the country, he said.

"We are seeing this from the East Coast to the West Coast."

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KentuckyOne's CEO cites health care reform as reason for layoffs

Awards recognize excellence in health care

Health care success stories happen every day in Powell River, and behind each story is a dedicated individual or team of professionals. Now is the time to recognize this care through completing a nomination for the 2014 Excellence in BC Health Care Awards.

Powell River nominations will be judged against those throughout the province and can be submitted by patients, peers and members of the public for service that improved health care delivery on the front lines and behind the scenes.

Ive always had great appreciation for people working in health care and feel it is important that they be recognized for the tremendous differences they make in the lives of others, said Terry Lake, minister of health. The Excellence in BC Health Care Awards is a great opportunity to recognize people and teams that have made an outstanding contribution to health care in BC.

Since the awards were created in 2007, 77 Gold Apples and 62 Awards of Merit have been given to health employees.

Nominations for the eighth annual awards are open until Friday, February 28. Readers can visit online, twitter or Facebook to learn more about the awards program and how to nominate. Winners will be announced at a luncheon in Vancouver on June 23.

Peak Online requires a one-time registration before commenting on stories but it's quick and free. Once you've registered you can comment as often as you'd like with no delay for moderators to clear your comment. So what are your 2 cents?! Sign me up now!

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With Motorola sale and Samsung peace, Google finds practical exit to an unconventional (and expensive) deal

10 hours ago Jan. 29, 2014 - 5:13 PM PST

In the nearly ten years Google has been a public company, it has been defined by a curious mixture of ambition, futurism, and unpredictability. This week, Google showed that it also knows when to move on.

The big announcement was Googles decision to offload its Motorola handset business to Lenovo for $2.91 billion. Snap reactions were easy to come by Wednesday afternoon. Those aligned with Google rivals Apple and Microsoft were quick to hoot at the bargain-basement selling price compared to the $12.5 billion Google agreed to pay for Motorola back in 2011. Those more inclined to support Google pointed out that Motorolas patents helped Google defend Android against patent attacks (to some degree) and that Googles intervention likely prevented an iconic mobile phone maker from folding completely.

(L to R): Google CEO Larry Page, Lenovo CEO Yang Yuanqing shake hands on $2.91 billion Motorola deal.

There are some nuggets of truth and gaping holes in each of those arguments. But a fundamental problem created by Googles Motorola acquisition is now solved: Google is no longer an operating system licensor that is also engaged in direct competition with its customers.

Lets look back at the week in full.

On Sunday, Google and Samsung, which was the company arguably most offended by Googles Motorola buy, worked out a global patent licensing deal. Earlier on Wednesday, Re/code reported that the companies had worked out an agreement in which Samsung would dial back its own software ambitions attendees at Samsungs Galaxy S 4 launch last March could have been forgiven for not realizing it was an Android phone and described the deal as a sea change in the relationship between the two companies.

What was the biggest obstacle to the relationship between Google and Samsung? Motorola.

It wasnt so much that Motorolas handsets were competitive: Samsung is dominating the Android handset market and leading the overall market for mobile phones. But the perception that Google intended to be a viable contender in the mobile phone business forced Samsungs mobile group to reconsider its dependency on Google.

Operating system developers who have tried to have it both ways licensing their software for a fee while also making hardware that competes with those customers have not done well. This was one of the (many) factors that sent Apple into a near-fatal tailspin in the 1990s, and forced Palm into a disastrous spin-off of its OS group in the 2000s. Once Microsoft absorbs Nokias handset business, its going to have some tough decisions to make about the future of its Windows Phone licensing model.

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With Motorola sale and Samsung peace, Google finds practical exit to an unconventional (and expensive) deal

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