Filjiug-Zero VS Agnosticism
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Filjiug-Zero VS Agnosticism - Video
Stem Cell Therapy - Obat segala penyakit
Stem cell therapy terbukti mampu sembuhkan kanker, stroke, diabetes, jantung, Parkinson, Alzheimer, AIDS, dll. Nikmati hidup bebas rasa sakit dan selalu awet...
By: Yohanes Wasono
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Stem Cell Therapy - Obat segala penyakit - Video
Purtier Placenta Stem Cell Therapy Presented By Dr. Chen
Presentasi Purtier Placenta oleh Dr. Chen Nikmati hidup bebas rasa sakit dan selalu awet muda bersama Purtier Placenta: http://www.stemcellworld.net.
By: Yohanes Wasono
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Purtier Placenta Stem Cell Therapy Presented By Dr. Chen - Video
A new method of producing stem cells is being described as a "game-changing" scientific breakthrough.
It is said that the research, carried out by scientists in Japan, could hail a new era of personalised medicine, offering hope to sufferers of diseases such as stroke, heart disease and spinal cord injuries.
The scientists bathed blood cells in a weak acidic solution for half an hour, which made the adult cells shrink and go back to their embryonic stem cell state. Using this process, a patient's own specially created stem cells could then be re-injected back into the body to help mend damaged organs.
The scientists in Japan used mice in this experiment but believe the approach may also work on human cells too.
The new method - much cheaper and faster than before - is being heralded as revolutionary, and could bring stem cell therapy a step closer, and all without the controversy linked to the use of human embryos.
But there is still research that some find ethically questionable.
On Inside Story: Is the controversy over using human embryos over? And how should ethics determine medical progress?
Presenter: Shiulie Ghosh
Guests:
Dusko Ilic, a reader in Stem Cell Science at King's College London School ofMedicine
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The ethics of medical progress
How to do the perfect squat - Better Exercise Physiology
In this basic video we demonstrate how to do the perfect squat including foot position, knee position, trunk angle. We also show adjustments to make it easie...
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How to do the perfect squat - Better Exercise Physiology - Video
LibraryConnect Tips for Anatomy Physiology
This video will show tips for using LibraryConnect to complete your assignments in MA110.
By: Online Librarians
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LibraryConnect Tips for Anatomy & Physiology - Video
Anatomy and Physiology: Integumentary System part II
Anatomy and Physiology: Integumentary System part II.
By: Bob Lin
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Anatomy and Physiology: Integumentary System part II - Video
PUBLIC RELEASE DATE:
2-Feb-2014
Contact: Lucy Holmes LHolmes@physoc.org 44-020-726-95727 Wiley
Vitamin C and E supplements may blunt the improvement of muscular endurance by disrupting cellular adaptions in exercised muscles suggests a new study published today [3 February] in The Journal of Physiology.
As vitamin C and E supplements are widely used, understanding if they interfere with cellular and physiological adaptations to exercise is of interest to people exercising for health purposes as well as to athletes.
Dr Gran Paulsen, who led the study at the Norwegian School of Sport Sciences, explains:
"Our results show that vitamin C and E supplements blunted the endurance training-induced increase of mitochondrial proteins, which are needed to improve muscular endurance."
In the 11-week trial, 54 young, healthy men and women were randomly allocated to receive either 1000mg vitamin C and 235mg vitamin E (consistent with amounts found in shop supplements), or a placebo (a pill containing no active ingredients). Neither the subjects nor the investigators knew which participant received the vitamins or placebos.
The participants completed an endurance training programme, consisting of three to four sessions per week, of primarily running. Fitness tests, blood samples and muscle biopsies were taken before and after the intervention.
Whilst the supplements did not affect maximal oxygen uptake or the results of a 20 metre shuttle test, the results showed that markers for the production of new muscle mitochondria the power supply for cells increased only in the group without supplements.
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Vitamin C and E supplements hampers endurance training
News Release
Short DNA sequences known as PAM (shown in yellow) enable the bacterial enzyme Cas9 to identify and degrade foreign DNA, as well as induce site-specific genetic changes in animal and plant cells. The presence of PAM is also required to activate the Cas9 enzyme. (Illustration by KC Roeyer.)
A central question has been answered regarding a protein that plays an essential role in the bacterial immune system and is fast becoming a valuable tool for genetic engineering. A team of researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley have determined how the bacterial enzyme known as Cas9, guided by RNA, is able to identify and degrade foreign DNA during viral infections, as well as induce site-specific genetic changes in animal and plant cells. Through a combination of single-molecule imaging and bulk biochemical experiments, the research team has shown that the genome-editing ability of Cas9 is made possible by the presence of short DNA sequences known as PAM, for protospacer adjacent motif.
Our results reveal two major functions of the PAM that explain why it is so critical to the ability of Cas9 to target and cleave DNA sequences matching the guide RNA, says Jennifer Doudna, the biochemist who led this study. The presence of the PAM adjacent to target sites in foreign DNA and its absence from those targets in the host genome enables Cas9 to precisely discriminate between non-self DNA that must be degraded and self DNA that may be almost identical. The presence of the PAM is also required to activate the Cas9 enzyme.
With genetically engineered microorganisms, such as bacteria and fungi, playing an increasing role in the green chemistry production of valuable chemical products including therapeutic drugs, advanced biofuels and biodegradable plastics from renewables, Cas9 is emerging as an important genome-editing tool for practitioners of synthetic biology.
Understanding how Cas9 is able to locate specific 20-base-pair target sequences within genomes that are millions to billions of base pairs long may enable improvements to gene targeting and genome editing efforts in bacteria and other types of cells, says Doudna who holds joint appointments with Berkeley Labs Physical Biosciences Division and UC Berkeleys Department of Molecular and Cell Biology and Department of Chemistry, and is also an investigator with the Howard Hughes Medical Institute (HHMI).
Jennifer Doudna and Samuel Sternberg used a combination of single-molecule imaging and bulk biochemical experiments to show how the RNA-guided Cas9 enzyme is able to locate specific 20-base-pair target sequences within genomes that are millions to billions of base pairs long. (Photo by Roy Kaltschmdit)
Doudna is one of two corresponding authors of a paper describing this research in the journal Nature. The paper is titled DNA interrogation by the CRISPR RNA-guided endonuclease Cas9. The other corresponding author is Eric Greene of Columbia University. Co-authoring this paper were Samuel Sternberg, Sy Redding and Martin Jinek.
Bacterial microbes face a never-ending onslaught from viruses and invasive snippets of nucleic acid known as plasmids. To survive, the microbes deploy an adaptive nucleic acid-based immune system that revolves around a genetic element known as CRISPR, which stands for Clustered Regularly Interspaced Short Palindromic Repeats. Through the combination of CRISPRs and RNA-guided endonucleases, such as Cas9, (Cas stands for CRISPR-associated), bacteria are able to utilize small customized crRNA molecules (for CRISPR RNA) to guide the targeting and degradation of matching DNA sequences in invading viruses and plasmids to prevent them from replicating. There are three distinct types of CRISPRCas immunity systems. Doudna and her research group have focused on the Type II system which relies exclusively upon RNA-programmed Cas9 to cleave double-stranded DNA at target sites.
What has been a major puzzle in the CRISPRCas field is how Cas9 and similar RNA-guided complexes locate and recognize matching DNA targets in the context of an entire genome, the classic needle in a haystack problem, says Samuel Sternberg, lead author of the Nature paper and a member of Doudnas research group. All of the scientists who are developing RNA-programmable Cas9 for genome engineering are relying on its ability to target unique 20-base-pair long sequences inside the cell. However, if Cas9 were to just blindly bind DNA at random sites across a genome until colliding with its target, the process would be incredibly time-consuming and probably too inefficient to be effective for bacterial immunity, or as a tool for genome engineers. Our study shows that Cas9 confines its search by first looking for PAM sequences. This accelerates the rate at which the target can be located, and minimizes the time spent interrogating non-target DNA sites.
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Running with genetic scissors: how a breakthrough technology works
A new gene-editing technique could lead to more useful animal models of disease, and perhaps one day more effective gene therapy for humans
Genetically modified long-tailed macaques. Credit: Cell, Niu et al.
Like many babies, the wide-eyed twins are cute. The fact that they are macaque monkeys is almost beside the point. What is not beside the point, however, is their genetic heritage. These baby macaques are, as reported inCell, the first primates to have been genetically modified using an extremely precise gene-editing tool based on the so-called CRISPR/Cas system.
Conducted by researchers in China, the new study is significant because it paves the way for the custom development of laboratory monkeys with genetic profiles that are similar to those found in humans with certain medical disorders. Although mice and rats have long been the animals of choice when creating living models of human disease, they have not been very helpful for studying neurological conditions such as autism and Alzheimers disease; the differences between rodent and human brains are just too great.
To be sure, a few other genetically modified monkeys have been born over the past decade and a half, but the methods used to alter their DNA were not as efficient or as easy to use as the CRISPR/Cas technology. The amount of genome engineering in monkeys is pretty small, says George Church, a professor of genetics at Harvard Medical School.So yes, this [paper] is a pretty big deal.
CRISPR stands for clustered regularly interspaced short palindromic repeats and refers to what at first glance appear to be meaningless variations and repeats in the sequence of molecular letters (A, T, C and G) that make up DNA. These CRISPR patterns are found in many bacteria and most archaea (an ancient group of bacteria that is now considered to be different enough from other one-celled organisms to merit is own taxonomic kingdom, along with bacteria, protists, fungi, plants and animals).
First identified in bacteria in 1987, CRISPR elements started being widely used to create genetic engineering tools only in 2013. It took that long to figure out that the patterns actually served a purpose, determine out what that purpose washelping archaea and bacteria to recognize and defend themselves against virusesand then adapt that original function to a new goal.
Basically, biologists learned that certain proteins associated with the CRISPR system (dubbed, straightforwardly enough, CRISPR-associated, or Cas, proteins) act like scissors that cut any strands of DNA they come across. These cutting proteins, in turn, are guided to specific strands of DNA by complementary pieces of RNA (a sister molecule to DNA). The bacteria generate specific guide strands of RNA whenever they encounter a virus that is starting to hijack their cellular machinery. The guide-RNA complements the viral DNA, which is how the Cas proteins know where to cut. The bacteria then keep a copy of the viral DNA in their own genetic sequence between two CRISPR elements for future reference in case a similar virus tries to cause trouble later on.
In the past couple of years researchers have learned how to trick the Cas proteins into targeting and slicing through a sequence of DNA of their own choosing. By developing strands of RNA that precisely complement the part of the DNA molecule that they want to change, investigators can steer the Cas proteins to a predesignated spot and cut out enough genetic material to permanently disrupt the usual expression of the DNA molecule at that location.
In essence, scientists have turned a bacterial self-defense mechanism into an incredibly precise gene-editing tool. By some accounts CRISPR technology has been successfully tried out on 20 different kinds of higher organisms (meaning higher than bacteria) in just the past year or so.
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New Biotech Makes It Much Easier to Genetically Modify Monkeys
PUBLIC RELEASE DATE:
31-Jan-2014
Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2100 x2156 Mary Ann Liebert, Inc./Genetic Engineering News
New Rochelle, NY, January 31, 2014In recognition of his seminal work on adenoviral vectors, which accelerated the translation of gene therapy from the research laboratory to the clinic, Ronald G. Crystal, MD (Weill Cornell Medical College, Cornell University, New York City), has received a Pioneer Award from Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. Human Gene Therapy is commemorating its 25th anniversary by bestowing this honor on the leading 12 Pioneers in the field of cell and gene therapy selected by a blue ribbon committee* and publishing a Pioneer Perspective by each of the award recipients. The article by Dr. Crystal is available on the Human Gene Therapy website.
Currently it is standard practice to use a modified virus as a transport vehicle to deliver therapeutic genes to patients. But this concept was new, innovative, and technically challenging when Dr. Crystal began developing the molecular tools and methods in the late 1980s. In the Pioneer Perspective "Adenovirus: The First Effective In Vivo Gene Delivery Vector," Dr. Crystal provides historical insights on the many years of research and testing needed to design, optimize, manufacture, and evaluate the performance of adenoviral vectors. He describes the first in vivo studies, the first human studies, and the many current applications of this useful gene delivery system.
"Ron led the way in the clinical translation of adenoviral vectors in the very early days of gene therapy," says James M. Wilson, MD, PhD, Editor-in-Chief of Human Gene Therapy, and Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.
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*The blue ribbon panel of leaders in cell and gene therapy, led by Chair Mary Collins, PhD, MRC Centre for Medical Molecular Virology, University College London, selected the Pioneer Award recipients. The Award Selection Committee selected scientists that had devoted much of their careers to cell and gene therapy research and had made a seminal contribution to the field--defined as a basic science or clinical advance that greatly influenced progress in translational research.
About the Journal
Human Gene Therapy, the official journal of the European Society of Gene and Cell Therapy, British Society for Gene and Cell Therapy, French Society of Cell and Gene Therapy, German Society of Gene Therapy, and five other gene therapy societies, is an authoritative peer-reviewed journal published monthly in print and online. Human Gene Therapy presents reports on the transfer and expression of genes in mammals, including humans. Related topics include improvements in vector development, delivery systems, and animal models, particularly in the areas of cancer, heart disease, viral disease, genetic disease, and neurological disease, as well as ethical, legal, and regulatory issues related to the gene transfer in humans. Its sister journals, Human Gene Therapy Methods, published bimonthly, focuses on the application of gene therapy to product testing and development, and Human Gene Therapy Clinical Development, published quarterly, features data relevant to the regulatory review and commercial development of cell and gene therapy products. Tables of content for all three publications and a free sample issue may be viewed on the Human Gene Therapy website.
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Ronald Crystal, M.D., receives Pioneer Award
Where We Are Today: Acritical Review Scientific Background of Anti-Aging Medicine
By: Klentze
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Where We Are Today: Acritical Review & Scientific Background of Anti-Aging Medicine - Video
Summit, New Jersey, (PRWEB) February 01, 2014
Ethos Spa Skin and Laser Center has announced a new line of specially formulated acne and anti-aging creams, customized skin care preparations that target multiple factors known to cause adult acne and exacerbate the signs of aging.
Hardik Soni, M.D., Medical Director of Ethos Spa Skin and Laser Centers in Summit and Englewood, has collaborated with a licensed pharmaceutical company to offer skin care products individually tailored to your skin.
Ethos Spa Acne/Anti-aging Prep has quickly become the most popular of the Ethos Spa line of skin care formulas developed specifically for the growing number of adults seeking treatment for acne, fine lines and wrinkles. Unlike many products developed to treat teen acne, Ethos Spa prep addresses adults over age 20 with the latest, most effective ingredients to meet the anti-aging qualities patients want, and the adult acne treatment they need.
Ethos Spa Prep ingredients include:
Ethos Spa Prep targets the unique causes of adult acne in both men and women, including androgens (male hormones) released by the adrenal gland when were under stress. These androgens stimulate more oil production, which can clog pores and lead to acne. Other hormonal fluctuations that can also cause acne can be triggered by a woman's monthly menstrual cycle, pregnancy or menopause.
Ethos Spa Prep is gentler and less drying than most acne treatments for teens, and has the added bonus of combating wrinkles, fading dark spots caused by sun exposure and aging, brightening and refreshing skin, and promoting skin health.
Ethos Spa Prep is available in gel and cream formulas, with ingredient concentrations that can be modified to address individual skin types.
A one-month supply costs $60.
Call to schedule your free consultation to see if Ethos Spa Prep can help you with your unique adult skin problems.
Celestial News Flash! Three Brightest Comets of 2014/Comet Triumvirate New Meteor Shower Possible
Hyperbolic comet C/2012-K1 (PanSTARRS) per JPL will now be at 4.7 magnitude for the Northern Hemisphere, and will be in the Inner Solar System during the sam...
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Edge Comets Showdown in O Town 2014
Showdown in O Town 2014.
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2 Comets, one Comet lives and one Comets final ride.
A video of a 1974 Comets final ride to the big bone yard in the sky. This car was hauled by the Cherry Picker for this video.
By: Comrick317
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2 Comets, one Comet lives and one Comets final ride. - Video
February 1, 2014 - American Hockey League (AHL) Utica Comets The Utica Comets have announced that tonight's game against the Rockford IceHogs is SOLD OUT.
This marks the second consecutive sellout and the seventh sellout for the Comets this season. It is the second time the Comets have sold out both games in a weekend. The previous weekend to sell out both games was Dec. 27 vs. Binghamton and Dec. 28 vs. Hamilton.
Tonight's sellout will give the Comets sellouts in three out of their last four home games, and four sell outs in their last five home weekend dates. After tonight's game, 79,947 people will have walked through the Utica Memorial Auditorium's doors to attend a Comets game. The season average of 3,331 per game is 87.3 percent of The AUD's capacity.
Tickets still remain for games on Saturday, Feb. 15 against Rochester, Wednesday, Feb. 26 vs. San Antonio and Friday, Feb. 28 vs. Adirondack. All games will start at 7 p.m.
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January 31, 2014 - American Hockey League (AHL) Utica Comets The Utica Comets put together one of their finest efforts of the season on home ice and defeated the Syracuse Crunch by a 3-1 score in front of a sold-out Utica Memorial Auditorium on Friday night. The win gave the Comets their fifth win over their past six games.
On 'Pink The Rink' night at The AUD, 3,815 hockey fans packed the building as the Crunch traveled down the Thruway for the second meeting of the season with the Comets. Brandon DeFazio, Pascal Pelletier and Darren Archibald each scored for Utica, who moved to 16-20-2-4 on the season. Joacim Eriksson, who was just 65 seconds away from his fourth career AHL shutout, made 31 saves on 32 shots for the victory.
The Comets and Crunch played to a scoreless first period, with Syracuse ahead 10-7 in shots on goal. The Comets had the period's best chance as Pascal Pelletier found a rebound in the slot, but his backhanded attempt was turned aside by Syracuse netminder Cedric Desjardins to keep the game scoreless.
Utica struck first just 3:24 into the second period as Brandon DeFazio put a silky smooth feed from Cal O'Reilly past Desjardins to open the scoring. DeFazio's goal was his sixth of the season, while O'Reilly picked up his fifteenth helper, third most on the Comets this season.
Pelletier doubled the advantage for Utica just over ten minutes later as he went backhand, forehand on Desjardins and slid the finish past the Syracuse netminder's stick side. With the goal, Pelletier moved to within two of the 500-point mark for his professional career. Wingers Alexandre Grenier and Darren Archibald picked up assists on the play.
Utica added an insurance goal with just over five minutes to play in the game, as Archibald drove the net and deflected Grenier's rebound past Desjardins. Pelletier moved back to a point-per-game pace with the secondary assist on the play. With his second helper of the evening, Grenier is now tied for seventh in the AHL amongst all first year players with 29 points (15-14-29).
The Crunch peppered Eriksson with shots down the stretch and were finally able to end the Swede's shutout bid with just 1:05 to play in the game. Defenseman Andrej Sustr slotted one past Eriksson, his first goal of the season, off of assists from Panik and Connolly. The helper was a team high eighteenth for Connolly, who is an AHL All-Star.
With the victory, Joacim Eriksson has moved to 12-10-1-2 on the season. Eriksson has been victorious in eight of his past ten starts and has moved into the AHL's Top 20 with a .915 save percentage. Defenseman Peter Andersson continued his team with another positive outing. The blueliner has netted a plus rating in each of his past six games and currently leads the team with a +9 rating this season. Despite two shots on net, winger Benn Ferriero saw his point scoring streak end at nine games.
Utica is back in action as they faceoff with the Rockford IceHogs for the first time in franchise history, tomorrow evening in the Mohawk Valley. The Comets are already nearing back-to-back sellouts for the second time this season. Puck drop is set for 7:00 p.m.
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