Comets Easily Sweep Ambush

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February 27, 2014 - Major Indoor Soccer League (MISL) Missouri Comets INDEPENDENCE, Missouri (February 27, 2014) - The Missouri Comets closed out their season series against the St. Louis Ambush with their sixth win versus the cross-state rival. Max Touloute led all scorers with five goals while Leo Gibson chipped in with four assists. Altogether, six different players scored for the Comets as they roll to a 27-6 victory.

Missouri got off to a hot start when Alex Megson tapped in a rebound off an early Gibson shot, then Max Touloute scored his first of night 30 seconds later to put the Comets up 4-0 in the first two minutes of the game. Stefan St. Louis and added a score before Touloute closed the opening period with another goal.

Leading 12-0, the Comets did not rest on their laurels and attacked with high pressure. John Sosa scored midway through the quarter and Touloute completed his hat trick towards the end of the half. Gibson assisted on three scores in the first half, helping his side to a 12-0 lead at the midway point.

The second half began just as the first did, with the Comets scoring less than 30 seconds into the period. This time Stefan Stokic found the net. Milan Ivanovic scored another impossible angle shot, followed by yet another Touloute score.

Leading 16-0, veteran goalkeeper Danny Waltman gave way to rookie Brendan Allen for the rest of the night.

The St. Louis Ambush finally got on the board with eight minutes remaining in the third period, but it was too little, too late for the home team.

Leo Gibson put his name in the goal-scorer column twice in the second half, after Touloute notched his fifth goal. The Ambush were able to score twice, but the Comets were never in danger as the finish 6-0 against their rivals from the east, final score 27-6.

Missouri travels to face the Milwaukee Wave at 2:00p.m. CT on Sunday, March 2nd for the final regular season game. With the win tonight, the Comets have secured the third seed in the MISL Playoffs and will face either the Wave or the Baltimore Blast on March 9th in Game 1 of the MISL Semi-Finals.

For group tickets and information call 855.4KC.GOAL or email tickets@kcproscoccer.com.

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Comets Easily Sweep Ambush

Comets Win, Lose In Regional

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Stew-Stras basketball got off to a good start in the Cumberland 1A Regional by beating Cumberland, 57-48. Then they lost their semifinal to Dieterich, 76-37.

The Comets were almost shut out in the 1st period on an 11-2 Toledo run. They then matched Toledo in the 2nd and reeled off a 16-9 run in the 3rd to knot the score, 29-29. The 4th was a jailbreak with both teams scoring 17 points and having the game called a draw at the end of regulation. In OT, the Comets flipped the coin on Cumberland. They answered the Pirates 11-2 run in the 1st with a Comet 11-2 run in OT for the win.

Cumberland made 21 field goals and Stew-Stras just 17. But, the Comets were 19-of-29 at the line and Cumberland just 5-of-8.

Monday

Toledo Regional

Stew-Stras 57, Cumberland 48 - OT

St-St 2-11-16-17-11--57

Cland 11-9-9-17-2--48

Stew stats: Helmuth 22 (4-2s, 2-3 pt FGs, 8/10 FTs), 11 rebounds, 5 steals; Fry 15 (4 FGs, 7/12 FTs), 5 rebounds, 3 steals, 3 assists; Jones 10 (2-2s, 2-3 pt FGs); Bugger 5 (FG, 3/5 FTs), Kessler 2 (FG), A. Blythe 2 (FG), Rincker 1 (1/2 FTs). Team FGs 17. 3-Pointers: 4 (Helmuth 2, Jones 2). Team FTs 19-of-29.

Cland stats: Shoan 12 (6 FGs), Bauguss 10 (3-2s, 1-3 pt FGs, 1/2 FTs), Mo. Wolke 9 (3 FGs, 3/4 FTs), McMechan 7 (3 FGs, 1/2 FTs), Napier 6 (3 FGs), Brumleve 4 (2 FGs). Team FGs 21 (1-3). Team FTs 5-of-8.

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Comets Win, Lose In Regional

CNIO researchers discover new strategies for the treatment of psoriasis

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27-Feb-2014

Contact: Nuria Noriega nnoriega@cnio.es Centro Nacional de Investigaciones Oncologicas (CNIO)

Almost ten years ago, the group led by Erwin Wagner, currently at the Spanish National Cancer Research Centre (CNIO), developed genetically modified mice showing symptoms very reminiscent to psoriasis. After publishing this discovery in Nature, the researchers decided to use this mouse model to study the underlying molecular pathways involved in disease development, and to look for innovative and efficient therapies. Now the group has discovered two possible novel treatments, based on existing pharmacological compounds, which are likely to cause fewer side effects.

Psoriasis affects up to 3% of the world's population and can seriously affect the quality of life of these patients. The primary causes are largely unknown and the disease is not curable. The latest generation of drugs developed to combat it - so-called biological therapies - are thought to be a big step forward, but can only be applied for limited periods of time due to serious side effects, which can generate other forms of psoriasis, or even cause tuberculosis or leukaemia. Due to this it is important for psoriatic patients to develop efficient non-toxic treatments.

The two new strategies now published by CNIO researchers are the result of in-depth studies of the disease biology that have revealed some of the underlying molecular causes.

In the first study published in the December issue of the high impact journal Immunity, it is shown how the symptoms of psoriasis disappear by deleting a protein called S100A9. In the second article, which is published in Science Translational Medicine, the researchers show that inhibiting a non-coding micro RNA, named miR-21, ameliorates the disease symptoms.

As Helia Schnthaler, the first author, and collegues write in Immunity: "over the past decade, biological therapies have been shown to be effective against inflammatory diseases. These treatments, however, are a cause of worry due to their side effects, which might cause a possible increase in the risk of infection or cancer. The development of efficient, locally applicable drugs without these side effects, therefore would be beneficial for patients with psoriasis". Specifically, S100A9 inhibiting strategies "have the potential to become effective new treatments against psoriasis", the authors state.

In the article in Science Translational Medicine, which features Juan Guinea-Viniegra as the lead author, the authors state that: "blocking miR-21 could offer advantages over current treatments given that the efficiency obtained is the same and the side effects are probably reduced". The authors highlight that in the mouse model and in patient samples transplanted into mice this new strategy "shows a significant therapeutic response".

Helia Schnthaler and Juan Guinea-Viniegra are members of the group of Erwin Wagner, who is the director of the F-BBVA-CNIO Cancer Cell Biology Programme.

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CNIO researchers discover new strategies for the treatment of psoriasis