NASA flies high with little oversight

WASHINGTON, D.C. - In 2011, NASA booked a flight for Ames Research Center Director Simon Pete Worden to fly first class from Washington D.C. to San Francisco. Cost of the one-way ticket: $14,773, versus the $189 average coach fare. Although the trip is reported in NASAs annual travel disclosure, the agency now says the flight never happened.

Worden, meanwhile, says he did take the flight. He explained by email to Scripps News that the trip included substantial foreign travel, and that he was authorized to fly first class for medical reasons. Yet, NASAs annual report accounting for its first and business class premium flights during 2011 includes no reports of foreign travel for Worden that year.

NASA is trying to resolve many of these kinds of disparities as it sorts out what it calls widespread errors in travel disclosures to the General Services Administration of its premium travel, according to Elizabeth Robinson, the space agencys chief financial officer. The errors date back to at least 2009, she said.

Weve identified some cases where there are inaccuracies and we are being very forthright about that and we are addressing those inconsistencies, said NASA communications director David Weaver.

Like many federal agencies, NASA must disclose all upgraded flights yearly. Those tickets often cost thousands of dollars more than coach fares.

NASA neglected to disclose an entire years worth of upgrades in 2012, and faced no repercussions. The agency is in the process of completing that report now.

The problem of lax oversight is not unique to NASA. Dozens of federal agencies regularly ignore requirements to disclose spending on premium fares, according to records recently released for the first time by the GSA. The agencys annual reports on premium travel reflect the ticket upgrades of 75 agencies from fiscal years 2009 to 2013, and indicate that 54 failed to file reports at least once during that period.

Scripps contacted all those agencies and received a mix of responses.

This is really embarrassing to admit thisbut no one here was aware of the provision, said Peg OLaughlin, spokesperson for the U.S. International Trade Commission. We are aware of it now and we plan to fully comply going forward. The National Science Foundation said it recently submitted a missing disclosure for fiscal year 2013 and is working on its report for 2012.

Eight other agencies contacted by Scripps said they would immediately begin disclosing their premium travel records. Eleven agencies disputed GSAs records and said they had filed on time.

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NASA flies high with little oversight

NASA contest offers prizes for citizen asteroid hunters

NASA is asking citizen scientists to help identify space rocks. NASA/MSFC/MEO/Aaron Kingery

Think you can find Earth-threatening asteroids faster than NASA? Then there is a contest designed just for you: the space agency is calling for citizen scientists to find new and improved ways to track down space rocks. And this isn't just for the good of all mankind - there's $35,000 in prize money.

The "Asteroid Data Hunter" contest starts on March 17 and runs through August. A partnership between NASA and Planetary Resources, Inc., the contest asks participants to create computer algorithms that can identify asteroids that are nearing Earth. They will be using images captured by ground-based telescopes.

"For the past three years, NASA has been learning and advancing the ability to leverage distributed algorithm and coding skills through the NASA Tournament Lab to solve tough problems," said Jason Crusan, NASA Tournament Lab director. "We are now applying our experience with algorithm contests to helping protect the planet from asteroid threats through image analysis."

The contest is part of NASA's Asteroid Grand Challenge, a program designed to find all potentially dangerous asteroids before they have a chance to reach Earth's atmosphere, where they could harm people and property.

"Current asteroid detection initiatives are only tracking one percent of the estimated objects that orbit the sun," Planetary Resources president and chief engineer Chris Lewicki said in the statement. "We are excited to partner with NASA in this contest to help increase the quantity and knowledge about asteroids that are potential threats, human destinations or resource rich."

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NASA spends millions to fly first and business class with little oversight

In 2011, NASA booked a flight for Ames Research Center Director Simon Pete Worden to fly first class from Washington D.C. to San Francisco. Cost of the one-way ticket: $14,773, versus the $189 average coach fare. Although the trip is reported in NASAs annual travel disclosure, the agency now says the flight never happened.

Worden, meanwhile, says he did take the flight. He explained by email to Scripps News that the trip included substantial foreign travel, and that he was authorized to fly first class for medical reasons. Yet, NASAs annual report accounting for its first and business class premium flights during 2011 includes no reports of foreign travel for Worden that year.

NASA is trying to resolve many of these kinds of disparities as it sorts out what it calls widespread errors in travel disclosures to the General Services Administration of its premium travel, according to Elizabeth Robinson, the space agencys chief financial officer. The errors date back to at least 2009, she said.

Weve identified some cases where there are inaccuracies and we are being very forthright about that and we are addressing those inconsistencies, said NASA communications director David Weaver.

Like many federal agencies, NASA must disclose all upgraded flights yearly. Those tickets often cost thousands of dollars more than coach fares.

NASA neglected to disclose an entire years worth of upgrades in 2012, and faced no repercussions. The agency is in the process of completing that report now.

The problem of lax oversight is not unique to NASA. Dozens of federal agencies regularly ignore requirements to disclose spending on premium fares, according to records recently released for the first time by the GSA.

The agencys annual reports on premium travel reflect the ticket upgrades of 75 agencies from fiscal years 2009 to 2013, and indicate that 54 failed to file reports at least once during that period.

Scripps contacted all those agencies and received a mix of responses.

This is really embarrassing to admit thisbut no one here was aware of the provision, said Peg OLaughlin, spokesperson for the U.S. International Trade Commission. We are aware of it now and we plan to fully comply going forward.

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NASA spends millions to fly first and business class with little oversight

Protein Key to Cell Motility Has Implications for Stopping Cancer Metastasis

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Newswise PHILADELPHIA - Cell movement is the basic recipe of life, and all cells have the capacity to move, says Roberto Dominguez, PhD, professor of Physiology at the Perelman School of Medicine, University of Pennsylvania. Motility albeit on a cellular spatial scale -- is necessary for wound healing, clotting, fetal development, nerve connections, and the immune response, among other functions. On the other hand, cell movement can be deleterious when cancer cells break away from tumors and migrate to set up shop in other tissues during cancer metastasis.

The Dominguez team, with postdoctoral fellow David Kast, PhD, and colleagues, report online ahead of print in Nature Structural & Molecular Biology how a key cell-movement protein called IRSp53 is regulated in a resting and active state, and what this means for cancer-cell metastasis.

We characterized how IRSp53 connects to the cell-motility machinery, says Kast. It does this by starting the formation of cell filopodia - extensions that form when a cell needs to move.

Cells move like an inchworm, explains Dominguez. Filopodia are at the leading edge of moving cells. The trailing end of the cell follows the move forward through contraction of actin and myosin in the cytoskeleton, much like muscle contraction. A cell pushes out the leading edge of its membrane, and sticks it down on whatever it is moving across, namely other cells, and then moves the cell body along, unsticking the back end. This sets the cell up for its next move.

IRSp53 contains a region called a BAR domain that binds to and shapes cell membranes. Other parts of the protein connect it to the cytoskeleton (internal bits that give a cell structure and shape). Together, through the binding of cell membranes and other proteins IRSp53 regulates cell movement. The team found that in the resting state, human IRSp53 adopts a closed shape that prevents it from interacting with the membrane and the cytoskeleton. However, the binding of a signaling protein, called Cdc42, opens IRSp53, setting in motion the recruitment of a complex cellular machinery needed for motility.

One of the cytoskeleton components IRSp53 connects to is the tumor-promoting protein Eps8. IRSp53 is synergistically activated by the combined action of Cdc42 and binding of Eps8, which is upregulated in metastatic cancers.

Co-authors Tatyana Svitkina and Changsong Yang from the Penn Department of Biology, brought their expertise with living cells to the study. By introducing normal and mutant proteins into cells they could see how these proteins induced filopodia to form. The team found that mutations in critical regions of IRSp53 can either lead to enhanced or reduced filopodia formation and, as a consequence, cell motility. This finding shows how all these different proteins converge on IRSp53 to execute precise cellular functions, and that when one factor is disrupted, other proteins are affected down the activity pathway, says Dominguez.

The teams next steps will be to screen libraries of small molecule inhibitors that interfere with the IRSp53-Eps8 interaction, to figure out how to stop unwanted cell movement before it gets too far.

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Protein Key to Cell Motility Has Implications for Stopping Cancer Metastasis

China kindergarten probed over unauthorized medicine prescription claims

XI'AN- A private kindergarten in Xi'an, capital of Shaanxi province, is being investigated after allegations that it gave children unauthorized prescription medicine.

Three school officials were detained by the police.

According to Huang Xiaohua, deputy secretary-general of the Xi'an municipal government, a joint investigation team from the city's education bureau, health bureau, food and medicine administration and public security bureau has been sent to the Feng Yun Kindergarten.

Sun Xuehong, the school's owner; Zhao Baoying, the manager; and Huang Linxia, the care physician, were all detained by the police, Huang said.

The 690 children attending the kindergarten were sent to a local hospital for health examinations on Wednesday, and those who were affected by the medicine would be treated, Huang said.

A mother surnamed Cheng discovered by chance that her 5-year-old daughter had taken a tablet of guanidine hydrochloride, a prescription anti-viral drug that should be given only by qualified doctors.

She wrote about the incident on her micro blog, creating a stir among parents of children who also attended the kindergarten.

"My daughter told me she took the medicine in the kindergarten on March 6, and I wondered why the kindergarten gave her the tablets, since she was not ill," Cheng said.

Guanidine hydrochloride is used to treat viral influenza or herpes virus infections and can have side effects, including sweating, loss of appetite and low blood sugar.

"The kindergarten never told us parents that they gave our kids that medicine, and we want to know why they did this," another mother, surnamed Wang, said.

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China kindergarten probed over unauthorized medicine prescription claims

Med school being named for Stryker founder

The Western Michigan University Homer Stryker M.D. School of Medicine will be housed at the W.E. Upjohn M.D. Campus downtown and welcome its first class this fall. Dr. Homer Stryker was a Kalamazoo orthopedic surgeon and medical device inventor.

"Dr. Homer Stryker's lifelong efforts to develop innovative medical products and procedures have saved thousands, if not millions, of lives throughout the world," U.S. Rep. Fred Upton, R-St. Joseph, said in a statement. "Naming WMU's medical school after such a dedicated doctor who created the products needed by his patients so they could recover faster and lead fuller lives bodes well for those entering the new program."

Stryker's first big product in 1940 was a turning frame for those with broken bones. He also developed a motorized saw to speed the removal of a cast without cutting the patient.

The entering class of 50 students is to arrive this fall.

The medical school is being named in Stryker's honor thanks to his granddaughter, Ronda E. Stryker, and her husband, William D. Johnston, a Western Michigan University trustee.

"I can't think of a more appropriate namesake," said university President John Dunn.

Stryker and Johnston are the donors who made a founding gift, anonymous at the time, in excess of $100 million to the university three years ago to launch the medical school initiative.

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Med school being named for Stryker founder

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