Lose Weight in 21 days. Purification at Bennett Acupuncture and Functional Medicine Fountain Valley – Video

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Lose Weight in 21 days. Purification at Bennett Acupuncture and Functional Medicine Fountain Valley
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Lose Weight in 21 days. Purification at Bennett Acupuncture and Functional Medicine Fountain Valley - Video

Penn Medicine researchers show how lost sleep leads to lost neurons

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PUBLIC RELEASE DATE:

18-Mar-2014

Contact: Jessica Mikulski jessica.mikulski@uphs.upenn.edu 215-349-8369 University of Pennsylvania School of Medicine

PHILADELPHIA - Most people appreciate that not getting enough sleep impairs cognitive performance. For the chronically sleep-deprived such as shift workers, students, or truckers, a common strategy is simply to catch up on missed slumber on the weekends. According to common wisdom, catch up sleep repays one's "sleep debt," with no lasting effects. But a new Penn Medicine study shows disturbing evidence that chronic sleep loss may be more serious than previously thought and may even lead to irreversible physical damage to and loss of brain cells. The research is published today in The Journal of Neuroscience.

Using a mouse model of chronic sleep loss, Sigrid Veasey, MD, associate professor of Medicine and a member of the Center for Sleep and Circadian Neurobiology at the Perelman School of Medicine and collaborators from Peking University, have determined that extended wakefulness is linked to injury to, and loss of, neurons that are essential for alertness and optimal cognition, the locus coeruleus (LC) neurons.

"In general, we've always assumed full recovery of cognition following short- and long-term sleep loss," Veasey says. "But some of the research in humans has shown that attention span and several other aspects of cognition may not normalize even with three days of recovery sleep, raising the question of lasting injury in the brain. We wanted to figure out exactly whether chronic sleep loss injures neurons, whether the injury is reversible, and which neurons are involved."

Mice were examined following periods of normal rest, short wakefulness, or extended wakefulness, modeling a shift worker's typical sleep pattern. The Veasey lab found that in response to short-term sleep loss, LC neurons upregulate the sirtuin type 3 (SirT3) protein, which is important for mitochondrial energy production and redox responses, and protect the neurons from metabolic injury. SirT3 is essential across short-term sleep loss to maintain metabolic homeostasis, but in extended wakefulness, the SirT3 response is missing. After several days of shift worker sleep patterns, LC neurons in the mice began to display reduced SirT3, increased cell death, and the mice lost 25 percent of these neurons.

"This is the first report that sleep loss can actually result in a loss of neurons," Veasey notes. Particularly intriguing is, that the findings suggest that mitochondria in LC neurons respond to sleep loss and can adapt to short-term sleep loss but not to extended wake. This raises the possibility that somehow increasing SirT3 levels in the mitochondria may help rescue neurons or protect them across chronic or extended sleep loss. The study also demonstrates the importance of sleep for restoring metabolic homeostasis in mitochondria in the LC neurons and possibly other important brain areas, to ensure their optimal functioning during waking hours.

Veasey stresses that more work needs to be done to establish whether a similar phenomenon occurs in humans and to determine what durations of wakefulness place individuals at risk of neural injury. "In light of the role for SirT3 in the adaptive response to sleep loss, the extent of neuronal injury may vary across individuals. Specifically, aging, diabetes, high-fat diet and sedentary lifestyle may all reduce SirT3. If cells in individuals, including neurons, have reduced SirT3 prior to sleep loss, these individuals may be set up for greater risk of injury to their nerve cells."

The next step will be putting the SirT3 model to the test. "We can now overexpress SirT3 in LC neurons," explains Veasey. "If we can show that we can protect the cells and wakefulness, then we're launched in the direction of a promising therapeutic target for millions of shift workers."

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Penn Medicine researchers show how lost sleep leads to lost neurons

Venture Investing in Life Science Start-ups: Dennis Purcell, Aisling Capital – Video

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Venture Investing in Life Science Start-ups: Dennis Purcell, Aisling Capital
On February 25, 2014, Dennis Purcell, Senior Managing Director, Aisling Capital, met with Orin Herskowitz, Executive Director at Columbia Technology Ventures...

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KU medical schools wins re-accreditation despite concerns

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Topeka The Kansas University Medical School won re-accreditation despite concerns voiced by KU officials to legislators that lack of funding for a $75 million health education building could have jeopardized accreditation. Even so, the need for a new building remains a concern going forward, officials said.

KU announced Monday that it received full accreditation for the next eight years, which is the longest period possible.

But the schools accreditors, the Liaison Committee on Medical Education (LCME), cited the school for noncompliance in two areas and said the school must show progress in six other areas by Aug. 1, 2015.

And one of those areas that the school must show progress in is improving its training facilities at the Kansas City, Kan., campus.

During the 2014 legislative session, KU officials have told legislators that without assistance in building a new $75 million health education building, the school faced accreditation problems.

On Monday, Douglas Girod, executive vice chancellor of the KU Medical Center, said the school was surprised it wasnt cited for an inadequate training building at the Kansas City campus after LCME visited the schools campuses in October 2013.

Based on comments from LCME visitors last fall, we anticipated a citation for lack of facilities appropriate for our curriculum, Girod said. We are fortunate they didnt issue a citation, but the accreditors made it clear this is an area that needs immediate attention.

The LCME said we are still in compliance, but that we need to fix the problem, Girod said. In August 2015, they wont be satisfied with were working on it. We need to show real progress on our building project in the next 17 months.

According to the LCME findings, students and faculty express dissatisfaction with the current state of facilities, including inadequate seating, particularly in the first-year lecture hall and the number of small-group classrooms that limit the schools ability to fully incorporate active learning on the Kansas City campus.

Girod said school officials are continuing discussions with Gov. Sam Brownback and the Legislature about the importance of the new building.

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KU medical schools wins re-accreditation despite concerns

Overcoming Satan`s Influence Bible Study Podcast – Liberty Cumberland Presbyterian Church – Video

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Overcoming Satan`s Influence Bible Study Podcast - Liberty Cumberland Presbyterian Church
Podcast - In this Bible Study Series we explore how to Overcome Satan`s Influence. Liberty Cumberland Presbyterian Church in Clarksville TN - http://www.clarksville...

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Overcoming Satan`s Influence Bible Study Podcast - Liberty Cumberland Presbyterian Church - Video