Shakira review: Another appealing album from a charming pop star

Is there anyone alive who doesnt have a special, secret fondness for Shakira? Besides maybe that famously angry sea lion who attacked the singer in 2012 and was presumably unaware of her selfless work with the United Nations and had probably never even heard She Wolf, because he would have really liked it.

Everyone else seems to have long ago succumbed to Shakiras hip-swiveling charms. Shes an avatar of pop-culture globalization a Colombian singer-songwriter of Lebanese descent whose songs are a multicultural grab bag of melodies from the Middle East, Africa, Latin America and, most prominently on her new, self-titled album, the American South. Shes a social-media giant. Statues have been erected in her honor. (Okay, one statue. Made of metal, not the hand-chiseled marble she deserves. And it depicts Shakira wearing pants she probably would never wear. But its a start.)

Shakira has weird, very specific tastes: Shakira is not her first album to feature near-lethal doses of reggae and 90s alt-rock, as if she hasnt realized that those things are mostly awful. Yet she also has the broadest canvas of any pop diva in memory she can contain multitudes, from cumbia to country, and still sound instantly, recognizably like herself.

Shakira, her charming, awkward, immensely appealing new disc, tests this theory. It was assembled by a murderers row of expensive producers and writers, including Dr. Luke, Max Martin and Cirkut. Any student of recent pop history knows what comes next: dignity-killing, one-size-fits-all dance-pop songs predestined for success and oblivion in the same month.

Shakira submits to Dr. Lukes dehumanizing ministrations and manages to come out the other end sounding only slightly less like herself. Dare (La La La) doubles as the background music for Shakiras new commercial for Activia yogurt, and it sounds like something Lady Gaga would have made before she became ridiculous. Its wonderful.

Most of the rest of Shakira seems like an uneasy bargain between what she wants (rootsy, often acoustic-based pop with a rangy feel and an affinity for early Alanis Morissette) and what the producers want (hits). Its familiar territory for the singer, who has routinely employed of-the-moment production teams to contemporize (and Americanize) her sound, but seldom has the divide seemed so great.

The best tracks split the difference: The new wave/reggae hybrid Cant Remember to Forget You is an energetic duet with Rihanna, pops favorite inanimate object. Loca por Ti (one of a handful of Spanish tracks on the standard edition of the album) is 80s jukebox country, finely rendered. The midtempo Latin pop track You Dont Care About Me recalls vintage Marc Anthony.

Shakira has four fully formed emotions Reproachful, Cheery, Lets Dance and I Want to Do Things to You. Thats two more than Dr. Luke usually has to work with, and she also has a voice thats hiccupy and distinct, especially at the wildest, warbliest reaches of her register. To make Shakira sound like everybody else takes some effort. On the discs weakest track, Spotlight, she sounds unerringly, depressingly, like Taylor Swift; the song sounds like a reheated Red outtake, and the vocal similarity is too marked to be accidental.

Swift is the unlikeliest of specters. But, if only because she is one of Shakiras few rivals who can credibly deliver a slender love song backed by an acoustic guitar, she also haunts the folk ballad 23, one of the albums starkest and best songs. Shakira has never been much of a lyricist, but 23 is clunkier, and braver, (I used to think that there was no god/ But then you looked at me with your blue eyes/ And my agnosticism turned into dust) than Swift would ever dare to be.

Shakiras comfort level seems to ebb and flow throughout the album: Shes commanding on the Spanish-language songs, playful on the bangers, subdued on the songs that are obviously ill-suited for her, such as the Nashville ballad Medicine, a collaboration with Blake Shelton, her fellow judge on The Voice. Its one of those duets where two famous people from different genres are joined by their business managers in pursuit of a crossover hit. They sing at each other and both sound as if theyd rather be anywhere else. Shelton, also at half-wattage, treats her with unusual delicacy, as if he was enlisted partly for his hit-making skills and partly to stop her from running away.

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Shakira review: Another appealing album from a charming pop star

Replacing insulin through stem cell-derived pancreatic cells under the skin

PUBLIC RELEASE DATE:

24-Mar-2014

Contact: Susan Gammon Ph.D. sgammon@sanfordburnham.org 858-795-5012 Sanford-Burnham Medical Research Institute

LA JOLLA, Calif., March 25, 2014 Sanford-Burnham Medical Research Institute (Sanford-Burnham) and UC San Diego School of Medicine scientists have shown that by encapsulating immature pancreatic cells derived from human embryonic stem cells (hESC), and implanting them under the skin in animal models of diabetes, sufficient insulin is produced to maintain glucose levels without unwanted potential trade-offs of the technology. The research suggests that encapsulated hESC-derived insulin-producing cells hold great promise as an effective and safe cell-replacement therapy for insulin-dependent diabetes.

"Our study critically evaluates some of the potential pitfalls of using stem cells to treat insulin-dependent diabetes," said Pamela Itkin-Ansari, Ph.D., adjunct assistant professor in the Development, Aging, and Regenerative Program at Sanford-Burnham, with a joint appointment at UC San Diego.

"We have shown that encapsulated hESC-derived pancreatic cells are able to produce insulin in response to elevated glucose without an increase in the mass or their escape from the capsule. These results are important because it means that the encapsulated cells are both fully functional and retrievable," said Itkin-Ansari.

In the study, published online in Stem Cell Research, Itkin-Ansari and her team used bioluminescent imaging to see if encapsulated cells stay in the capsule after implantation.

Previous attempts to replace insulin-producing cells, called beta cells, have met with significant challenges. For example, researchers have tried treating diabetics with mature beta cells, but because mature cells are fragile and scarce, the method is fraught with problems. Moreover, since the cells come from organ donors, they may be recognized as foreign by the recipient's immune systemrequiring patients to take immunosuppressive drugs to prevent their immune system from attacking the donor's cells, ultimately leaving patients vulnerable to infections, tumors, and other adverse events.

Encapsulation technology was developed to protect donor cells from exposure to the immune systemand has proven extremely successful in preclinical studies.

Itkin-Ansari and her research team previously made an important contribution to the encapsulation approach by showing that pancreatic islet progenitor cells are an optimal cell type for encapsulation. They found that progenitor cells were more robust than mature beta cells to encapsulate, and while encapsulated, they matured into insulin-producing cells, which secreted insulin only when needed.

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Replacing insulin through stem cell-derived pancreatic cells under the skin

UW-Madison professor debunks therapeutic stem cell tourism

University of Wisconsin-Madison law and bioethics professor Alta Charo works to raise awareness for the dangers of stem cell tourism, according to a university press release Monday.

Stem cell tourism refers to people who travel within the United States and abroad in the pursuit of stem cells. These people are often sick and desperate and are falsely led to believe stem cell therapy can cure an array of medical conditions, Charo said in the release.

Advertisements for stem cell clinics often tout their treatments, but although patients all over the world are convinced stem cells will cure their disease, little data exists that proves the effectiveness of using stem cell therapeutically, according to Charo.

Not only are some stem cell treatments advertised by clinics questionable and often useless, they can also be dangerous, according to the release.

We already have had two reported deaths of children, and there are probably more injured than anybody would imagine, Charo said in the release. Its time we started complaining a little more loudly.

Though there have been instances of approved and unapproved treatments in the United States, many clinics that pose danger exist outside the country. Clinics in China are responsible for about half of all stem cell treatments, and Mexico, Russia and Costa Rica also have defective clinics, according to the release.

Charo emphasized the importance of regulation and realism when dealing with stem cells.

It is time to lose the hype without losing the hope, she said in the release.

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UW-Madison professor debunks therapeutic stem cell tourism

Forget drugs: You can beat psoriasis by TALKING about it

Toby Hadoke, 40, from London has suffered with psoriasis since childhood Has recently found a surprising treatment - cognitive behavioural therapy

By Grace Mccann

PUBLISHED: 20:12 EST, 24 March 2014 | UPDATED: 20:14 EST, 24 March 2014

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Toby Hadoke has suffered with psoriasis since childhood. The condition, which causes red, scaly patches of skin, is distressing and can be painful.

'At its worst, I felt like I'd been stung by a thousand bees,' says Toby, a 40-year-old comedian and writer from north London.

But recently he's found a surprising treatment that has transformed his symptoms. Much of his skin used to be covered in flaky patches. Today, these areas are merely slightly pink and dry.

Toby Hadoke, 40, from London has suffered with psoriasis since childhood and has recently found a treatment

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Forget drugs: You can beat psoriasis by TALKING about it

BSU professor headed to International Space Station Tuesday

by Jamie Grey

KTVB.COM

Posted on March 25, 2014 at 6:25 AM

Updated today at 7:03 AM

BOISE -- The countdown is on for Boise State University's Professor of the Practice and NASA astronaut Steve Swanson to launch into space.

Swanson will leave earth with two Russian cosmonauts on Tuesday around 3:15 p.m. MT. He is scheduled to arrive at the International Space Station (ISS) just after 9 p.m.

The students Swanson is working with, called the "Space Broncos," are eagerly awaiting his mission. They plan to use the project they've dubbed "Team Swanson" to make science accessible to everyone, by engaging students and the rest of the community.

Boise State University freshman mechanical engineering major Camille Eddy is one of the Space Broncos and hopes one day she'll be doing science in space.

"I've found that my passion is definitely research, like space science, anything like that, even going to space, I'm up for that," Eddy said.

Eddy and students from each of BSU's colleges will be working on a variety of projects that will incorporate Swanson's mission. Swanson will help the Space Broncos create two educational videos for college students and will participate in a live Q&A during a student-planned "Space Symposium" set for May 6.

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BSU professor headed to International Space Station Tuesday

Soyuz rocket ready to launch joint U.S.-Russian space crew

A veteran Russian space station commander, a rookie cosmonaut and a NASA shuttle flier are set for launch aboard a Russian Soyuz ferry craft Tuesday, kicking off a four-orbit rendezvous with the International Space Station to boost the lab's crew back to six.

Steve Swanson, Alexander Skvortsov and Oleg Artemyev will launch aboard the Soyuz TMA-12M spacecraft. Photo credit: NASA/Victor Zelentsov Despite Russia's annexation of Crimea and escalating superpower tit-for-tat sanctions, U.S. and Russian space engineers are continuing to cooperate on the high frontier, jointly operating the most complex spacecraft ever built.

Three fresh crew members - Soyuz TMA-12M commander Alexander Skvortsov, flight engineer Oleg Artemyev and NASA astronaut Steven Swanson -- are scheduled to blast off from the Baikonur Cosmodrome in Kazakhstan Tuesday at 5:17:23 p.m. EDT (GMT-4; 3:17 a.m. Wednesday local time).

If all goes well, Skvortsov will oversee an automated docking at the station's upper Poisk module around 11:04 p.m. Tuesday. Standing by to welcome the trio aboard will be Expedition 39 commander Koichi Wakata, cosmonaut Mikhail Tyurin and NASA astronaut Rick Mastracchio.

Wakata and his two crewmates have had the station to themselves since March 11 when Soyuz TMA-10M commander Oleg Kotov, Sergey Ryazanskiy and Mike Hopkins returned to Earth. Wakata and his crewmates are scheduled to follow suit in their Soyuz TMA-11M ferry craft on May 13.

That will clear the way for launch of Soyuz TMA-13M commander Maxim Suraev, a Russian space veteran, and two rookies: European Space Agency astronaut Alexander Gerst and NASA astronaut Reid Wiseman.

In a March 18 interview in Houston, Suraev said escalating tension over Russia's actions in Ukraine, and the response of the United States and its allies, "is something for big bananas and some politician guys, not for us."

"We are just doing our job," he said, speaking in heavily accented English. "We are flying, we are studying, we are training, we are cosmonauts." Then, with a laugh, he added "for me personally, I'm not ready to answer this question, especially before my flight! Especially when I'm here in the U.S., especially when I'm interviewing U.S. media! Ask this of our politician guys."

Wiseman, a former Navy F-14 carrier pilot, was less reticent, saying "the politics starts to fall by the wayside" when working with Russian space engineers, flight controllers and cosmonauts on a daily basis.

"Working with my commander and all the Russian trainers over there, these people are not just my colleagues, they're all my friends," he said. "And so sure, we don't want to see political turmoil, and it could ultimately get in the way of our spaceflight.

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Soyuz rocket ready to launch joint U.S.-Russian space crew

Pioneer Award recipients Marina Cavazzana and Adrian Thrasher recognized for advancing gene therapy to the clinic for …

PUBLIC RELEASE DATE:

24-Mar-2014

Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, March 24, 2014Marina Cavazzana, MD, PhD, Paris Descartes University, France and Adrian J. Thrasher, MD, PhD, University College London Institute of Child Health, UK, have been honored with the Pioneer Award for basic and clinical gene therapy for immunodeficiency disorders. Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers, is commemorating its 25th anniversary by bestowing this honor on the leading 12 Pioneers in the field of cell and gene therapy selected by a blue ribbon panel* and publishing a Pioneer Perspective by the award recipients

Dr. Cavazzana has been at the forefront of advances in treating life-threatening inherited diseases of the immune system with gene therapy, using a patient's own modified stem cells. She describes the translation of this work to the clinic and its ongoing advances and novel applications in the article "Hematopoetic Stem Cell Gene Therapy: Progress on the Clinical Front." The article by Dr. Cavazzana is available free on the Human Gene Therapy website at http://online.liebertpub.com/doi/full/10.1089/hum.2014.2504.

A pioneer of gene therapy in the UK, Dr. Thrasher has been at the leading edge of basic science research on the function of therapeutic genes for inherited disorders and the development of viral vectors to deliver them to affected patients. He has collaborated on gene therapy clinical trials targeting immunodeficiency disorders with groups in Europe and the USA.

"Cell therapy and gene therapy are advancing together to improve patient care," says Dr. Cavazzana. "We can expect to be able to rebuild a new immune system not only in primary immunodeficiencies but also in severe acquired clinical conditions (such as those in HIV-1-infected patients)."

"I've seen some very exciting times in the field, from the first evidence that biochemical defects can be corrected in vitro, to some remarkable clinical successes in patients with devastating diseases. I look forward with huge enthusiasm to the exciting developments on the horizon, which are likely to impact on more patients with an even wider range of disorders," says Dr. Thrasher.

"These pioneers contributed to the first real clinical successes of gene therapy through their work in inherited immune deficiency disorders," says James M. Wilson, MD, PhD, Editor-in-Chief of Human Gene Therapy, and Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.

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Pioneer Award recipients Marina Cavazzana and Adrian Thrasher recognized for advancing gene therapy to the clinic for ...

Coloradan blasts off today for 6-month space job

Colorado native Steve Swanson is scheduled to lift off for space on Tuesday.

Swanson, who grew up in Steamboat Springs and graduated from the University of Colorado, will launch on a Soyuz spacecraft with two Russian cosmonauts. He's expected to spend the next six month on the International Space Station.

Swanson has flown into space twice before on NASA Space Shuttles, before that program was retired.

"Each time I was up there with my shuttle flights, it was only two weeks long and I just wanted to stay," Swanson told 7NEWS.

To prepare for the upcoming six-month expedition, Swanson has spent years in training. Although he and his fellow cosmonauts will spend just a few days aboard the Soyuz, Swanson spent months traveling between the United States and Russia to train for the trip.

"It's like starting a roller coaster ride," said Swanson describing the launch he has trained for.

After the Soyuz carries the crew to the ISS, hundreds of miles above the Earth, Swanson will assume the role of flight engineer for Expedition 39. Every crew visiting the station overlaps and when Expedition 39's members depart a few weeks later, Swanson will become the commander of Expedition 40.

-- This trip begins long before takeoff

"I just always loved to explore," the graduate of Steamboat Springs High School said.

"I'd just go hike around, you know, the areas where we were camping, and I used to love doing that, I think that's kind of the same idea, I love to explore," he added.

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Coloradan blasts off today for 6-month space job

Launch Alert! Three People Set For Space Station Flight Today Heres How To Watch Live

Want to stay on top of all the space news? Follow @universetoday on Twitter

Despite tensions on the ground between the United States and Russia, officials say that its business as usual on the International Space Station. The three people launching to space today, in fact, are from both countries:Alexander Skvortsov and Oleg Artemyev of the Russian Federal Space Agency (Roscosmos), andSteve Swanson from NASA.

As has been the habit lately, the Expedition 39/40 crew will take a faster route to the International Space Station that see launch and docking happen in the same day, should all go to plan. It all begins with the launch at 5:17 p.m. EDT (9:17 p.m. UTC) from the Baikonur Cosmodrome in Kazakhstan, with docking scheduled to happen at 11:04 p.m. EDT (3:04 a.m. UTC).

Bear in mind that schedules are subject to change, so its a good idea to watch NASA TV (see video above) well before each milestone to see if things are happening on time. Once the crew arrives at station, one big question is if theyll do spacewalks when they get there.

Last July, Italian astronaut Luca Parmitano experienced a severe water leak in his NASA spacesuit that sent the crew scrambling back to the station. While Parmitano emerged physically all right, the agency opened an investigation and suspended all non-essential activities. A report was issued in February and the agency pledged to deal with all the urgent items quickly.

Spacewalks are planned for Expedition 40, but only if these urgent items are cleared in time for that. (That expedition begins in May and will include NASA astronauts Alex Gerst, Reid Wiseman andMaxim Suraev.)

Steve Swanson, commander of Expedition 40, during a spacewalk on 2007 shuttle mission STS-117. Credit: NASA

Elizabeth Howell is the senior writer at Universe Today. She also works for SPACE.com, Astronomers Without Borders, Space Exploration Network, the NASA Lunar Science Institute, NASA Astrobiology Magazine and LiveScience, among others. Career highlights include watching three shuttle launches, and going on a two-week simulated Mars expedition in rural Utah. You can follow her on Twitter @howellspace or contact her at her website.

Tagged as: alexander skvortsov, expedition 39, expedition 40, oleg artemyev, Roscosmos, steve swanson

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Launch Alert! Three People Set For Space Station Flight Today Heres How To Watch Live

US Military's XS-1 Space Plane Project Seeks $27 Million in 2015 Funding

WASHINGTON The U.S. Defense Advanced Research Projects Agency expects to spend some $800 million on space programs from 2015 through 2018, an increase of $130 million over what was projected at this time last year, Defense Department budget documents show.

Nearly all of the targeted increase for DARPA's Space Programs and Technology Office is backloaded into the outyears, the documents show. For 2015, the office is seeking nearly $180 million, only $7.5 million more than this years funding level.

DARPA's budget books break out funding on a program-by-program basis for the upcoming fiscal year only; outyear projections are provided only at the department level. [NASA Space Tech, Science & Exploration Goals in 2015 (Gallery)]

DARPA's mission, generally speaking, is to pursue high-risk, high-payoff technology development projects that could someday benefit the military. These projects are taken on with the understanding that many, if not most, will fail. Defense Department officials often talk about "DARPA-hard" programs to describe their degree of difficulty.

For example, the 2015 request includes $27 million for XS-1, a concept for a reusable space planethat could ultimately fly 10 times in 10 days and boost payloads into low-Earth orbit for less than $5 million per launch. The program received $10 million in 2014.

"Technologies derived from the XS-1 program will enable routine space launch capabilities with aircraft-like cost, operability and reliability," a DARPA announcement from November 2013 reads. "The long-term intent is for XS-1 technologies to be transitioned to support not only next-generation launch for Government and commercial customers, but also global reach hypersonic and space access aircraft."

The agency hopes to select a single vendor next year for the final design and development of the vehicle, which could make its initial test flight in 2018.

DARPA sees the program potentially transitioning to the Air Force, the Navy or a commercial operator, the budget documents said.

The budget request also includes $55 million for the Airborne Launch Assist Space Access (ALASA) program, which is intended to field a system to launch satellites weighing up to 100 lbs (45 kilograms) for $1 million each. The agency requested $42 million for the program in fiscal year 2014.

DARPA awarded ALASA system concept studies contracts last year to Boeing, Lockheed Martin and Virgin Galactic, and technology-development contracts to three other companies.

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US Military's XS-1 Space Plane Project Seeks $27 Million in 2015 Funding