Ontarios performance in health care is uncompetitive among international peers – Institute for Competiveness …

Institute for Competiveness & Prosperity report calls for a re-think of how Ontario delivers and finances health care

TORONTO, ON In Working Paper 20, Building better health care: Policy opportunities for Ontario, the Institute for Competitiveness & Prosperity examines how the performance of the Ontario health care system compares internationally on dimensions of efficiency and equity, and analyzes what drives health care costs. The Institute finds that, overall, Ontario could get better value for money from its health care spending. Ontario is among the jurisdictions with the highest total per capita health care spending in the OECD, with spending 33 percent above the OECD average. Yet despite exceptional resources, Ontario trails international peers in overall health care performance. Countries that spend less on health care have comparable or better health care outcomes, higher quality care, and more extensive public coverage than Ontario.

Ontario cannot afford to maintain the status quo of its health care system. Although spending on health care has recently slowed, over the last decade public expenditures on health care have continuously outpaced the provinces economic growth rate and its ability to raise revenue. If major changes are not made now, rising health care expenditures could lead to further deficit financing, rationing of health care and higher tax burdens on the working age population.

To have a health care system that is affordable, yet provides high quality care, Ontario needs to tackle the main cost drivers. Institute research shows that population aging is a contributor to rising health care cost, but its significance may be exaggerated. There is a need to control age-specific cost increases and attention related to end of life care is critical. Advances in technology, primarily drugs, increased service utilization, and physician compensation growth are more influential causes behind rising health care spending, but that remain largely unaddressed in current policy initiatives, even when these factors, unlike aging, hold significant potential for policy intervention.

The Institute offers eight policy opportunities for Ontario to make headway in realizing greater efficiency and equity in health care. These include strengthening primary care, engaging physicians to drive change, accelerating the deployment of IT, implementing a pharmacare program, and scaling up policy focus on end of life care, as well as strengthening the revenue base by introducing a savings plan for prefunding drugs, implementing a co-payment model and abolishing the tax subsidy for employer health insurance benefits.

The Institute urges Ontarians to consider what we give up in spending more on health care. More money for health care means less money available for investment in education, infrastructure, and other pressing societal needs. Neglecting these areas is a huge challenge to the provinces future prosperity. Ontario will not be able to afford the cost of its public services unless it prioritizes spending on areas that will drive economic growth and, in turn, revenue.

Our research shows that Ontario could be getting considerably more bang for its buck in health care, and new priorities are needed to make our health care system work smarter, says Roger Martin, Chair of the Institute for Competitiveness & Prosperity. This Working Paper is the first in a series of research papers on health care, and our goal is to contribute to the discussion of strategies that can be used to raise the performance of Ontarios health care system.

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Ontarios performance in health care is uncompetitive among international peers - Institute for Competiveness ...

New gene variant found increases the risk of colorectal cancer from eating processed meat

PUBLIC RELEASE DATE:

17-Apr-2014

Contact: Jane C. Figueiredo janefigu@usc.edu PLOS

A common genetic variant that affects one in three people appears to significantly increase the risk of colorectal cancer from the consumption of processed meat, according to study published today in PLOS Genetics. The study of over 18,000 people from the U.S., Canada, Australia and Europe represents the first large-scale genome-wide analysis of genetic variants and dietary patterns that may help explain more of the risk factors for colorectal cancer. Dr Jane Figueiredo at the Keck School of Medicine of the University of Southern California, explained that eating processed meat is associated with an increased risk of colorectal cancer and for about a third of the general population who carry this genetic variant, the risk of eating processed meat is even higher compared to those who do not. "Our results, if replicated by other studies, may provide us with a greater understanding of the biology into colorectal carcinogenesis," said Dr Ulrike Peters of the Fred Hutchinson Cancer Research Center's Public Health Sciences Division.

The study population totaled 9,287 patients with colorectal cancer and a control group of 9,117 individuals without cancer, all participants in 10 observational studies that were pooled in the largest meta-analysis sponsored by the National Institutes of Health-funded Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) and Colorectal Cancer Family Registry. Scientists systematically searched 2.7 million variants to identify those that are associated with the consumption of meat, fiber, fruits and vegetables. A significant interaction between the genetic variant rs4143094 and processed meat consumption was detected. This variant is located on the same chromosome 10 region that includes GATA3, a transcription factor gene previously linked to several forms of cancer. The transcription factor encoded by this gene plays a role in the immune system. Dr Figueiredo hypothesized that the genetic locus found to interact with processed meat may have interesting biological significance given its location in the genome, but further functional analyses are required.

Colorectal cancer is a multi-factorial disease attributed to both genetic causes and lifestyle factors; including diet. About 30 known genetic susceptibility alleles for colorectal cancer have been pinpointed throughout the genome. How specific foods affect the activities of genes has not been established but represents an important area of research for prevention. "The possibility that genetic variants may modify an individual's risk for disease based on diet has not been thoroughly investigated but represents an important new insight into disease development," said Dr Li Hsu, the lead statistician on the study. "Diet is a modifiable risk factor for colorectal cancer. Our study is the first to understand whether some individuals are at higher or lower risk based on their genomic profile. This information can help us better understand the biology and maybe in the future lead to targeted prevention strategies," said Dr Figueiredo.

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New gene variant found increases the risk of colorectal cancer from eating processed meat

Gene variant raises risk for aortic tear and rupture

PUBLIC RELEASE DATE:

17-Apr-2014

Contact: Helen Dodson helen.dodson@yale.edu 203-436-3984 Yale University

New Haven, Conn. Researchers from Yale School of Medicine and Celera Diagnostics have confirmed the significance of a genetic variant that substantially increases the risk of a frequently fatal thoracic aortic dissection or full rupture. The study appears online in PLOS ONE.

Thoracic aortic aneurysms, or bulges in the artery wall, can develop without pain or other symptoms. If they lead to a tear dissection or full rupture, the patient will often die without immediate treatment. Therefore, better identification of patients at risk for aortic aneurysm and dissection is considered essential.

The research team, following up on a previous genome-wide association study by researchers at Baylor College of Medicine, investigated genetic variations in a protein called FBN-1, which is essential for a strong arterial wall. After studying hundreds of patients at Yale, they confirmed what was found in the Baylor study: that one variation, known as rs2118181, put patients at significantly increased risk of aortic tear and rupture.

"Although surgical therapy is remarkable and effective, it is incumbent on us to move to a higher genetic level of understanding of these diseases," said senior author John Elefteriades, M.D., the William W. L. Glenn Professor of Surgery (Section of Cardiac Surgery) at Yale School of Medicine, and director of the Aortic Institute at Yale-New Haven Hospital. "Such studies represent important steps along that path."

The researchers hope their confirmation of the earlier study may help lead to better clinical care of patients who may be at high risk of this fatal condition. "Patients with this mutation may merit earlier surgical therapy, before aortic dissection has a chance to occur," Elefteriades says. Yale cardiothoracic surgeons will now begin assessing this gene in clinical patients with aneurysm disease.

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The Yale-New Haven Hospital Aortic Institute opens April 22. It will specialize in clinical care, basic science, and clinical research in aortic disease.

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Gene variant raises risk for aortic tear and rupture

Stanford scientists develop 'playbook' for reverse engineering tissue

PUBLIC RELEASE DATE:

16-Apr-2014

Contact: Tom Abate tabate@stanford.edu 650-736-2245 Stanford University Medical Center

STANFORD, Calif. Consider the marvel of the embryo. It begins as a glob of identical cells that change shape and function as they multiply to become the cells of our lungs, muscles, nerves and all the other specialized tissues of the body.

Now, in a feat of reverse tissue engineering, Stanford University researchers have begun to unravel the complex genetic coding that allows embryonic cells to proliferate and transform into all of the specialized cells that perform myriad biological tasks.

A team of interdisciplinary researchers took lung cells from the embryos of mice, choosing samples at different points in the development cycle. Using the new technique of single-cell genomic analysis, they recorded what genes were active in each cell at each point. Though they studied lung cells, their technique is applicable to any type of cell.

"This lays out a playbook for how to do reverse tissue engineering," said Stephen Quake, PhD, the Lee Otterson Professor in the School of Engineering and a Howard Hughes Medical Institute investigator.

The researchers' findings are described in a paper published online April 13 in Nature. Quake, who also is a professor of bioengineering and of applied physics, is the senior author. The lead authors are postdoctoral scholars Barbara Treutlein, PhD, and Doug Brownfield, PhD.

The researchers used the reverse-engineering technique to study the cells in the alveoli, the small, balloon-like structures at the tips of the airways in the lungs. The alveoli serve as docking stations where blood vessels receive oxygen and deliver carbon dioxide.

Treutlein and Brownfield isolated 198 lung cells from mouse embryos at three stages of gestation: 14.5 days, 16.5 days and 18.5 days (mice are usually born at 20 days). They also took some lung cells from adult mice.

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Stanford scientists develop 'playbook' for reverse engineering tissue

Broad Institute Gets Patent on Revolutionary Gene-Editing Method

The Harvard-MIT genomic science institute stays mute on how it will assert control over the tools expected to speed cures and change gene therapy.

One of the most important genetic technologies developed in recent years is now patented, and researchers are wondering what they will and wont be allowed to do with the powerful method for editing the genome.

On Tuesday, the Broad Institute of MIT and Harvard announced that it had been granted a patent covering the components and methodology for CRISPRa new way of making precise, targeted changes to the genome of a cell or an organism. CRISPR could revolutionize biomedical research by giving scientists a more efficient way of re-creating disease-related mutations in lab animals and cultured cells; it may also yield an unprecedented way of treating disease (see Genome Surgery).

The patent, issued just six months after its application was filed, covers a modified version of the CRISPR-Cas9 system found naturally in bacteria, which microbes use to defend themselves against viruses. The patent also covers methods for designing and using CRISPRs molecular components.

The inventor listed on the patent is Feng Zhang, an MIT researcher and core faculty member of the Broad. Zhang was an MIT Technology Review Innovator Under 35 in 2013.

The patent describes how the tools could be used to treat diseases, and lists many specific conditions from epilepsy, to Huntingtons, to autism, and macular degeneration. One of the most exciting possibilities for CRISPR is its potential to treat genetic disorders by directly correcting mutations on a patients chromosomes. That would enable doctors to treat diseases that cannot be addressed by more traditional methods, a goal already set by a startup cofounded by Zhang called Editas Medicine (see New Genome-Editing Method Could Make Gene Therapy More Precise and Effective).

Another founder of Editas, Jennifer Doudna, and her institute, the University of California, have a pending patent application for CRISPR technology. How that west coast application will be affected is not yet clear. Its also unclear what impact the Broads claims on the technology will have on its commercial use and on basic research.

Chelsea Loughran, an intellectual property litigation lawyer who has been following CRISPR over the last year, says that lots of people are already using CRISPR and its not clear if it will now become harder for them to do that. All of that is in the hands of MIT and the Broad, she says.

While MIT, Harvard, and the Broad all jointly own the CRISPR patents announced yesterday, the Broads technology licensing office is managing decisions about who will get licenses to use the technology, says Lita Nelsen, director of the MIT Technology Licensing Office. (Licenses areformal permissions to use a patented technology, often in exchange for money.)

A spokesperson for the Broad says that specific details around licensing arent available at this time, but the Broad does intend to make this technology broadly available to scientists.

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Broad Institute Gets Patent on Revolutionary Gene-Editing Method

Greenaway's New Exhibit Dramatizes Russian Avant-Garde

Timothy Misir / MTLarge screens scattered throughout Manezh show projections of historical figures played by actors, who move from screen to screen and interact.

The Soviet Union in early 20th century, a time of social and political upheaval, was also an artistic utopia, and saw the interplay of suprematism, constructivism and futurism separate but connected art movements.

Moscow Manege

Anactor plays Sergei Eisenstein.

Collectively known as theRussian avant-garde, theater directors like Sergei Eisenstein, poets like Mayakovsky anddesigners such as Alexander Rodchenko, composers, architects andartists like Kandinsky, Malevich andLizzitsky were just afew of the many who tried topushed theboundaries ofculture andits possibilities.

Anew exhibition byDutch theater director Saskia Boddeke andBritish filmmaker Peter Greenaway, "The Golden Age ofthe Russian Avant-Garde" dramatizes these characters andimmerses viewers inthe context ofthat period, exploring thelives andworks ofits key figures through thelanguage oftheater andcinema. Twelve pivotal figures fromthe period of1910 to1930, played byRussian actors, are used totell thestory ofthis period ofcultural experimentation andinnovation.

More than 1,000 artworks, sourced fromgalleries andprivate collections around theworld, are displayed as part ofthe exhibit, but Greenaway andBoddeke add tothat byshowing thecontext inwhich these masterpieces were created, theexchange ofideas between artists andthe debates that surrounded them, pieced together frommemoirs, manifestos, newspaper articles, published works andpersonal artifacts.

The characters are shown on multi-screen projections fused with photos, film reels and film clips. They interact with each other, speaking and arguing across screens, and move from one screen to another. They are not presented in a fixed order, running in 15-minute loops, and one can move randomly from viewing one platform to another.

Moscow Manege

Anna Shepeleva plays Lilya Brik.

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Greenaway's New Exhibit Dramatizes Russian Avant-Garde

John Di Lemme – LifeStyle Freedom Club *Member ONLY* Sneak Peek Millionaire MasterMind Event – Video


John Di Lemme - LifeStyle Freedom Club *Member ONLY* Sneak Peek Millionaire MasterMind Event
LIVE MasterMinding with John Di Lemme! Sneak into the Private Member Only LifeStyle Freedom Club MasterMind Event.- http://www.LifestyleFreedomClub.com Recor...

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John Di Lemme - LifeStyle Freedom Club *Member ONLY* Sneak Peek Millionaire MasterMind Event - Video

Freedom To Choose: How School Choice Revitalized Education In An American City (2002) – Video


Freedom To Choose: How School Choice Revitalized Education In An American City (2002)
A case study of the positive effects of school choice on Milwaukee, Wisconsin, sponsored by the American Education Reform Council. With commentary from Spenc...

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Freedom To Choose: How School Choice Revitalized Education In An American City (2002) - Video

Pastor Mike Stottlemyer – Delegated Authority of the Believer – 04/16/2014 – Message Of Freedom Chur – Video


Pastor Mike Stottlemyer - Delegated Authority of the Believer - 04/16/2014 - Message Of Freedom Chur
Pastor Mike Stottlemyer - Delegated Authority of the Believer - 04/16/2014 - Message Of Freedom Chur.

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Rubio expresses 'concern' over still-vacant State Dept. religious freedom post

U.S. Sen. Marco Rubio speaks at Uber's headquarters March 23, 2014 in Washington, DC.Getty

Sen. Marco Rubio is questioning why a key State Department position that promotes religious freedom around the world has been left vacant for months, calling the delay a concern.

In a letter to President Obama Tuesday, Rubio, R-Fla., said he finds it troubling that no new ambassador-at-large has been appointed for the Office of International Religious Freedom since Suzan Johnson Cooks resignation six months ago.

The office within the State Department develops policies regarding religious freedom and monitors religious discrimination and persecution worldwide. The department also releases an annual report on international religious freedom, which discusses the state of religious freedom in every country in the world.

Rubio said these important tasks require a highly-qualified individual be appointed to the post as soon as possible. He told Obama it is essential that the U.S. continue to be a beacon of hope for all persecuted religious minorities.

In your speech to the National Prayer Breakfast you explained that promoting religious freedom is a key objective of U.S. foreign policy because it is in Americas interest to promote universal human rights, including with our allies, Rubio said. In order to display the United States dedication to religious freedom, we must have an Ambassador-At-Large in place to lead our efforts around the world.

At the National Prayer Breakfast on Feb. 6, Obama said is he looking forward to appointing a new ambassador-at-large for international religious freedom, but gave no indication when he may do so.

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Rubio expresses 'concern' over still-vacant State Dept. religious freedom post

Freedom from Religion debate heats up at Warren City Hall

Mother finds pill mixed in with Easter egg's candy Mother finds pill mixed in with Easter egg's candy

Updated: Thursday, April 17 2014 6:37 PM EDT2014-04-17 22:37:43 GMT

A mother says her preschooler found something dangerous inside her Easter egg.

A mother says her preschooler found something dangerous inside her Easter egg.

Updated: Thursday, April 17 2014 6:18 PM EDT2014-04-17 22:18:59 GMT

Ferndale police are asking for the public's help locating a suspect after an armed robbery was committed at a doctor's office. He is also wanted for other dangerous crimes.

Ferndale police are asking for the public's help locating a suspect after an armed robbery was committed at a doctor's office. He is also wanted for other dangerous crimes.

Updated: Thursday, April 17 2014 5:49 PM EDT2014-04-17 21:49:08 GMT

A car drove into a Dairy Queen-Orange Julius shop late Thursday afternoon.

A car drove into a Dairy Queen-Orange Julius shop late Thursday afternoon.

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Freedom from Religion debate heats up at Warren City Hall