Many genes are switched on by default

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Contrary to common scientific belief, many genes are switched "on" by default. These findings are from a study by Prof. Dr. Frank Holstege of University Medical Center (UMC) Utrecht that has been published in the April 24 edition of Cell.

Genetic differences between individuals affect the origin and treatment of diseases, a fact that has prompted more and more wide-scale genetic research. However, it seems that we sometimes lack very basic genetic knowledge.

Holstege's research shows that contrary to common opinion, many genes are by default actually switched "on". Given that DNA is wrapped in proteins, most scientists assumed that it could not be read by the cell. Transcription can only begin when so-called transcription factors bind to the DNA. Holstege and his colleagues show that nearly half of the transcription factors actually prevent the DNA from being read. It would seem that in most circumstances these genes should first be actively switched "off".

1,600 genes analyzed

Holstege and his colleagues used yeast as the model organism for their research. Yeast may seem far removed from humans, but its genes are controlled in exactly the same way as in human cells. Holstege et al. analyzed the role played by 1,600 genes, a quarter of all known yeast genes. They studied the effect that mutations in all those genes have on the gene expression of all other genes. This is the largest systematic study of the effect of mutation on gene expression to date.

Holstege has previously demonstrated that it is actually not necessarily useful to look at the effect of changes in just one gene. All genes are active in networks that are often organized in such a way that they can replace defective genes (Cell, December 10, 2010). The new study is the first step to mapping out the entire genetic control network.

"Comparative genetic research into patients and healthy subjects is very important," says Holstege. "It provides information on the cellular pathways associated with diseases. Our research shows, however, that it's hard to understand cells if you don't take the simultaneous activity of all genes into account."

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Many genes are switched on by default

Profiles International Chief Science Officer to Attend 29th Annual Society for Industrial and Organizational …

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Waco, TX (PRWEB) April 25, 2014

Employee assessment solutions provider, Profiles International, is pleased to announce that Dr. Scott Hamilton, Chief Science Officer of Profiles International, will attend the 29th Annual Society for Industrial and Organizational Psychology Conference on May 15-17 in Honolulu, Hawaii.

In his role as Chief Science Officer, Dr. Hamilton represents Profiles throughout the world, providing consulting and support for clients and representatives.

At the conference, Dr. Hamilton will be attending sessions on Leadership Development, Talent Management, Consulting Practices, Global Cultural Issues, Team Effectiveness, Ethical Issues, and Employee Engagement. Dr. Hamilton is also an active member in many other professional organizations, including the Association of Test Publishers, the International Test Commission, the Association for Psychological Science, and the British Psychological Society.

"The SIOP conference has been a great resource for me in the years past," said Dr. Hamilton. "I look forward to applying all that the conference has to offer this year to business at Profiles."

For more information on the 29th Annual SIOP Conference, click here.

ABOUT SOCIETY FOR INDUSTRIAL AND ORGANIZATIONAL PSYCHOLOGY SIOP is the premier membership organization for those practicing and teaching industrial-organizational psychology. While an independent organization with its own governance, SIOP is also a division within the American Psychological Association and an organizational affiliate of the Association for Psychological Science. SIOP members and sponsors research and apply the psychological principles governing behavior to a wide variety of applications, such as workforce planning, employee selection, leader development, team building, and organizational change. http://www.siop.org

ABOUT PROFILES INTERNATIONAL Profiles International is the best source for talent management solutions, with over 20 years' experience and more than 40,000 clients in over 120 countries. Profiles knows how people work and what motivates them. Their data-driven talent management solutions--built on complex behavioral science, yet simple to administer and read--help organizations find the right people, shape them into a winning team, and lead them to their full potential. http://www.profilesinternational.com

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Anti-Aging Medicine | Dayton Medical Center Miami

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We all want to live a long and healthy life full of energy, vitality and mental clarity as we age. Vibrant health and prolonged youthfulness are attained by choosing lifestyle and medical stategies wisely. These vital choices help reverse processes that deplete health and lead to premature aging.

Although the majority of human health needs are similar, each individual has their own unique health requirementsthat are never the same as that of anyone else. Effective evaluation of such requirements is imperative for optimizing healthy longevity. Because health is too dear to be left to chance, medical wisdom and technologies from around the world are often employed to address patient needs at Dayton Medical Center. For example, after diagnostic evaluation modern bio-identical hormone therapies from the west may be prescribed along with time proven herbal formulations from the east for synergistic benefits.

A youthful external appearance reflects the result of internal revitalization. At Dayton Medical Center our wellness and anti aging medicine strategies focus on biological function and repair to support youthful vitality.

The Center can partner with you to achieve this goal by conducting an effective evaluation to optimize your own unique path to healthy longevity.

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Anti-Aging Medicine | Dayton Medical Center Miami

World famous Australian doctor Mark Mitchelson reveals for the first time in history his natural anti-aging secrets.

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Brisbane, Queensland (PRWEB) April 25, 2014

World famous Australian doctor for the first time in history, reveals his natural anti-aging health secrets absolutely for free.

Dr Mark Mitchelson, where "West Meets East", is the original "Feel Good" doctor.

Dr Mark Mitchelson, who has 21 years of general medical clinical experience, was originally trained as a western general medical doctor in Australia and has just finished an intensive 10 year period of study in eastern medical practices, which compliments his western medical training. This includes the use of various anti-aging vitamins, minerals, certain herbs and super foods that when used in combination with his world leading exercise and dietary programs, can most definitely help to minimize the signs of visible aging in clients from around the world, without either the use of invasive surgery or western pharmaceutical drugs. Naturally, because of these facts, there will be almost no risk whatsoever to any clients who choose to participate, because all protocols involved in this program are of a completely natural and non-invasive nature.

This is the first time in recorded history that a non-invasive natural anti-aging protocol this detailed has ever been released to the general public for their general health benefit.

Dr Mark Mitchelson's world leading work in the field of natural anti-aging medicine has been proudly sponsored by Amazon.com.

Hence, for complete enlightenment and all other inquiries, please visit Dr Mark Mitchelson's specially dedicated website, where all inquiries from potential clients will be answered upon receipt immediately.

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World famous Australian doctor Mark Mitchelson reveals for the first time in history his natural anti-aging secrets.

Inside the Comets: In-Game Host Cecelie Pikus

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April 25, 2014 - American Hockey League (AHL) Utica Comets It isn't easy keeping up with Cecelie Pikus at The AUD during games.

It's till a couple of hours before game time and Pikus, a Hamilton College graduate, keeps a steady presence and pace at The AUD. She has to - it's her responsibility. As the in-game host during Comets home games, what sponsorships, products, and contests fans have become quite familiar with, that seems to be the easier part of her title.

What and where Pikus is needed has become routine. When the Syracuse Crunch were on the ice for their pre-game warm-ups during their only appearance in Utica this season, Pikus was close to the skaters. On the opposite side of the glass of the Crunch, with two minutes to go before the ice is to be cleared of players and the zambonis take over, Pikus is meeting with the woman who will sing the national anthem. It's Pink the Rink Night, the Comets' contribution in recognizing breast cancer awareness. Pikus is demonstrating her commitment to stamping out the disease that overwhelming effects woman, by wearing her rose pink pants.

As the last of the players heads back to the visiting team's dressing room, Pikus is still concentrating on making sure the national anthem goes off without a hitch. There is a contingency of boy scouts who will accompany the singer out on to the ice. Pikus is administering last minute instructions for adults and scouts.

Details are what Pikus' responsibilities with the Comets are all about. By drop of the puck this Friday evening, Pikus will have been in The AUD for nine hours - with several more to go. After uploading pre-cut highlights to CometsTV for public viewing, Pikus' schedule will likely have her leave Oriskany Street West approximately one and a half hours after each home game.

With no prior experience working before thousands of people at a time, there are no visible pre-game, or in-game nerves for that matter, for the Short Hills, New Jersey native. "I've never done this before, except a public speaking class at Hamilton," says Pikus. "Opening night I was a little nervous but much less now."

As the pre-game ceremony is unfolding, the two ceremonial puck drops make things a little more complicated for Pikus. Still in her rhythm, all come off as planned. The rugs placed on the ice for the flag-bearing scouts and those being recognized are being rolled up, and scooped off the playing surface. Next up for Pikus, she will be doing a live promo for First Source Credit Union, a Comets corporate sponsor, halfway through the first period of this and every home game.

"I have no script. I pretty much wing it; ad lib," Pikus, who shares the same hometown with such notables as former New Jersey Devils Brian Rolston and actress Anne Hathaway, tells.

The small-town atmosphere of Hamilton (Pikus' brother currently attends her alma mater) and the Mohawk Valley, appeals so much to Cecelie that she decided to remain in the area after graduation. She tells of many of her classmates moving to New York City and Chicago for employment. Coming from a commuter town where a large portion of its residents work in the 'Big Apple', Pikus gives the impression that, for now at least, she won't be changing her New Hartford address.

Relaxed and enjoying the comings and goings throughout The AUD's nearby lower bowl seated fans, Pikus high-five's one of the evening's cameraman's young son. So, how did Pikus get her foot in the Comets' proverbial door? Completing a summer internship for the New Jersey Devils in their social media and marketing department was a big influence for her career path.

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Inside the Comets: In-Game Host Cecelie Pikus

Comets Win Ramsey Invite

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April 25, 2014 Comets Win Ramsey Invite

JOHN CURTIS - Daily Union Sports Editor CNHI The Shelbyville Daily Union Fri Apr 25, 2014, 03:44 PM CDT

SHELBYVILLE, IL. With a 2-1 record in the Ramsey softball invite last weekend, Stew-Stras/Windsor was declared the winner after tie-breakers were figured out.

Stew-Stras/Windsor ran their record to 10-3 as they won the Ramsey tourney. SS/W lost to Hillsboro, 4-3, in eight innings. They bounced back by defeating Ramsey, 13-1, and ALAH, 6-1.

After figuring the tie-breaker format, the Comets were declared the 1st place team. Stew-Stras/Windsor and Arthur-Lovington/Atwood-Hammond (ALAH) finished 2-1. Hillsboro and Ramsey finished 1-2.

Stew-Stras/Windsor is off to the best start in about 15 years and they are playing through a lot of injuries.

"We lost our starting left fielder the second game of the year (broken thumb) and our starting center fielder went down against T'town with an ankle injury," said Coach Kyle Knop.

"Kendall Knop had to pitch 9 of the first 10 games, because Courtney Schultz was out with an elbow injury when the season started and could not pitch. becca Schlechte was out of pitching for three weeks with a hip flexor injury.

"The girls have played hard and players have stepped up when we have had injuries."

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Comets Win Ramsey Invite

IBM100 – Blue Gene – IBM – United States

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Over the past 100 years, high-end IBM machines have consistently ranked among the most powerful on the planet. When IBM Blue Gene was unveiled in 2004, it was both the most powerful supercomputer and the most efficient, consuming only a fraction of the energy and floor space of any other supercomputer.

The introduction of Blue Gene ushered in a new era of high-performance computing, continuing a long IBM tradition. Developed and manufactured in collaboration with the US Department of Energy's Lawrence Livermore National Laboratory in California, Blue Gene was originally built to help biologists observe the invisible processes of protein folding and gene development. Hence the name.

From an engineering standpoint, the guiding principle was simple but innovative: do more with less. When a small team of IBM engineers and scientists began developing the prototype for the Blue Gene /L in 1999, they were looking to make a radical departure from how supercomputers were being designed at the time. For decades, supercomputers had defined the state-of-the-art in high-performance computing and communications; but if their architecture stayed the same, the machines would soon require football field-sized buildings to house them. Worse, they would use enough electricity in one year to power a mid-size town, and they would require yet more power to prevent them from overheating.

Enter Blue Gene and a US$100 million, five-year development effort by IBM. Designed to harness thousands of low-power, cooler-running processors, the first IBM Blue Gene/L was built at the IBM lab in Rochester, Minnesota. On September 29, 2004, the new machine surpassed NEC's Earth Simulator as the fastest computer in the world.

Whereas IBMs previous champ, IBM Deep Blue , had 32 processors and could calculate about 200 million potential chess moves per second in its historic six-game victory over a chess grand master in 1997, Blue Gene/L used 131,000 processors to routinely handle 280 trillion operations every second. A single scientist with a calculator would have to work nonstop for 177,000 years to perform the operations that Blue Gene could do in one second. The Blue Gene/L was also noteworthy for its choice of operating system, Linux , and its support for the development of open source applications.

Perhaps more important than its speed was the way Blue Gene/L revolutionized the economics of supercomputing, due to its small size and power efficiency. Each Blue Gene rack contained 1024 dual-processor nodes in a footprint that dramatically reduced floor space. The processors were engineered to be so tiny that 32 of them fit on a single microchip.

Blue Gene/L was a landmark in supercomputing, but its real work had only begun. IBM researchers then began to explore the wide range of applications that would run on the system. The computers speed and expandability enabled universities, governments and commercial research labs to address a wide range of problems that had simply been too complex to tackle. And leaders could also make more informed decisionsnot just in life sciences, but also in astronomy, climate, drug development, cosmology and many other fields.

In September 2009, United States President Barack Obama recognized IBM and the Blue Gene family of supercomputers with the National Medal of Technology and Innovation, the country's most prestigious award given to leading innovators for technological achievement. And the influence of the Blue Gene/L energy-efficient design and computing model can be seen today across the information technology industry.

Blue Gene systems have helped map the human genome, investigated medical therapies, simulated radioactive decay, replicated brain power, flown airplanes, pinpointed tumors, predicted climate trends and identified fossil fuels. Much more progress lies ahead. When Blue Gene /P, the familys second generation, was unveiled in 2007, it nearly tripled the performance of Blue Gene/L, immediately becoming the most energy-efficient and space-saving computing package built, at that point in time.

On February 8, 2011, IBM announced the 10-petaflop Blue Gene/Q supercomputer Mira, in collaboration with the US Department of Energy's (DOE) Argonne National Laboratory located near Chicago, Illinois. Mira was designed to enable significant advances in designing ultra-efficient electric car batteries, understanding global climate change, exploring the evolution of our universe and more. IBM continues to explore the cutting edge of high-performance computing as part of its ongoing quest to change the way research and science can be done.

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IBM100 - Blue Gene - IBM - United States

Greater Community Spirituality (Chapter Fifteen) Part Three – Video

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Greater Community Spirituality (Chapter Fifteen) Part Three
https://www.newmessage.org/nmfg/Greater_Community_Spirituality.html Greater Community Spirituality presents a prophetic new understanding of God and human spirituality within a larger arena...

By: DanielofDoria02

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Greater Community Spirituality (Chapter Fifteen) Part Three - Video