NASA's Orion spacecraft tested in anticipation of maiden flight

NASA has successfully completed the latest series of tests for its next-generation Orion Spacecraft, currently housed at the Kennedy Space Center. The latest trials focused on vibration-testing the spacecraft, simulating the stress that Orion will be subjected to during its maiden test flight scheduled to take place in December.

Orion is due to serve as NASA's go-to vehicle for both low-Earth orbit and manned deep space missions. NASA boasts that Orion will be the most advanced and safest spacecraft ever designed, allowing manned spaceflight to reach hitherto impossible destinations, including missions to near-Earth asteroids, and in the longer term, a trip to Mars.

The most recent set of tests, carried out between April 17-24, was conducted by NASA scientists alongside a team from Lockheed Martin, in order to simulate the high levels of stress that the prototype spaceship will be subjected to during its maiden test flight. Orion was placed in a specialized vibration stand, isolated from the floor and ceiling, with sensitive components such as the spacecraft's windows, thrusters and parachutes covered and cantilevered in order to protect them from the jarring ordeal.

The Orion spacecraft mounted in a vibration stand, ready to undergo stress testing (Photo: NASA/Daniel Casper)

Twin electromagnetic shakers were fitted to either side of the spacecraft's hull, each of which was capable of simulating 4,000 pounds of force. Once one area of the craft was stress-tested, the shakers were removed and attached to another segment of the hull, continuing the process until Orion was fully tested. As the shakers were operational, readings were taken from accelerometers and strain gauges placed throughout the crew compartment, informing the team whether any elements of the design had failed to perform within expected parameters. Following each stage of stress testing, the hull of the spacecraft was thoroughly checked by system specialists for flaws that may have been exposed under pressure.

"It was a great accomplishment for the test team in preparation for the Exploration Flight Test-1 later this year," states Orion Program Test and Verification lead scientist Rafael Garcia. "Following months of preparations and pretest analysis, the multi-point random vibration test was conducted without any major issues and was completed two days ahead of schedule."

Orion's first test flight, due to take place this December, will take the form of the uncrewed spacecraft being launched into space to test critical systems whilst being subjected to punishing pressures. Once in space it will complete one full orbit, and before its return to Earth it will fire its thrusters one more time, pushing the spacecraft to a height of 3,600 miles (5,794 km) above the Earth.

This will be done in order to increase the pressure upon re-entry. At that time, at a speed of around 20,000 mph (32,187 km/h) and withstanding temperatures of 4,000F ( 2,204C), the spacecraft's heat shield will be put under extreme pressure. This is a vital test, required to determine whether the craft could adequately protect a human crew on a return mission from outer space. The maiden voyage will come to an end with the craft deploying its parachutes, and coming to rest in the Pacific Ocean.

The video below displays a computer simulation of the maiden test flight.

Source: NASA

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NASA's Orion spacecraft tested in anticipation of maiden flight

Brain Tumor Cells Penetrated by Tiny, Biodegradable Particles Carrying Genetic Instructions

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Newswise Working together, Johns Hopkins biomedical engineers and neurosurgeons report that they have created tiny, biodegradable nanoparticles able to carry DNA to brain cancer cells in mice.

The team says the results of their proof of principle experiment suggest that such particles loaded with death genes might one day be given to brain cancer patients during neurosurgery to selectively kill off any remaining tumor cells without damaging normal brain tissue.

A summary of the research results appeared online on April 26 in the journal ACS Nano.

In our experiments, our nanoparticles successfully delivered a test gene to brain cancer cells in mice, where it was then turned on, says Jordan Green, Ph.D., an assistant professor of biomedical engineering and neurosurgery at the Johns Hopkins University School of Medicine. We now have evidence that these tiny Trojan horses will also be able to carry genes that selectively induce death in cancer cells, while leaving healthy cells healthy.

Green and his colleagues focused on glioblastomas, the most lethal and aggressive form of brain cancer. With standard treatments of surgery, chemotherapy and radiation, the median survival time is only 14.6 months, and improvement will only come with the ability to kill tumor cells resistant to standard treatments, according to Alfredo Quiones-Hinojosa, M.D., a professor of neurosurgery at the Johns Hopkins University School of Medicine and a member of the research team.

Because nature protects the brain by making it difficult to reach its cells through the blood, efforts turned to the use of particles that could carry tumor-destroying DNA instructions directly to cancer cells during surgery.

The initial experiments made use of cancer cells that Quiones-Hinojosa and his team removed from willing patients and grew in the laboratory until they formed little spheres of cells, termed oncospheres, likely to be the most resistant to chemotherapy and radiation, and capable of creating new tumors.

Quiones-Hinojosa then worked with Green to find a vehicle for genes that would cause death in the oncospheres. Greens laboratory specializes in producing tiny, round particles made up of biodegradable plastic whose properties can be optimized for completing various medical missions. By varying the atoms within the plastic, the team can make particles that have different sizes, stabilities and affinities for water or oil. For this study, Greens team created dozens of different types of particles and tested their ability to carry and deliver a test sequence of DNA specifically a gene for a red or green glowing protein to the oncospheres.

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Brain Tumor Cells Penetrated by Tiny, Biodegradable Particles Carrying Genetic Instructions

Two Professors at SDSM&T Making Big Impact on Modern Medicine

Created: Tue, 29 Apr 2014 06:27:00 MST

Updated: Tue, 29 Apr 2014 06:36:36 MST

Two professors at the South Dakota School of Mines are behind the technology for the start-up company "Nanofiber Separations," and the research they are conducting at the school could ultimately have a big impact on modern medicine and the pharmaceutical industry.

Dr. Todd Menkhaus and Dr. Hao Fong are behind this technology, using tiny nano fibers that provide a highly efficient filtration mechanism.

This technology replaces all processing steps with a single step that can purify a material all at once, ultimately helping to reduce costs and waste.

The company recently won the Governor's Giant Vision Business Competition and has received nearly $710,000 to help commercialize and produce nano fiber filters for lower cost pharmaceutical purification's.

"Because we can offer a much lower cost of production opportunity for a company making the pharmaceutical product, the goal would be that those savings that the company creates by manufacturing it with our product, would be passed on to the consumer, you would end up with a low cost pharmaceutical that you would have to pay for," said Dr. Todd Menkhaus, an Associate Professor in the Chemical and Biological Engineering at the School of Mines.

This technology can also be used for water and air purification, greatly reducing the cost and waste as well.

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Two Professors at SDSM&T Making Big Impact on Modern Medicine

Nano Utica job fair draws thousands

Story Created: Apr 29, 2014 at 5:52 PM EDT

Story Updated: Apr 29, 2014 at 5:52 PM EDT

(WKTV) - Substitute teacher Natalie Williams came to the Nano Utica Job Fair looking for something more permanent. She also wanted to see what all the buzz was about, after hearing people say nanotechnology would transform the Utica area into the Silicon Valley of New York.

Williams came up with an interesting analogy of her own.

"I haven't personally been on a speed date but in my mind it seems kind of like that," said Williams.

"I'm a teacher. A biology teacher, chemistry teacher ... and I don't know if you've noticed but there aren't too many jobs in that field. With that skill set, I can go in a lot of different directions ... so I'm looking to see what the options are."

Not everyone at the Nano Utica Job Fair had a background or skills in science or engineering.

"I'm looking for a security position ... security guard, security supervisor. It's what I have the most experience in, so..." said job seeker Clarence Chester.

Chester illustrates something Nano Utica officials say it's important to convey: They need professionals from all disciplines to make Quad C-the Computer Chip Commercialization Center at SUNYIT a success.

Local elected leaders were thrilled at the overwhelming response to the job fair.

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Nano Utica job fair draws thousands

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