20140510140318 – Highlands and Islands Explorer Arrives into Perth – Video

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20140510140318 - Highlands and Islands Explorer Arrives into Perth
Day 2 of the Highlands and Islands Explorer, and this video is taken from a footbridge just beyond the tunnel as the train nears Perth Station from the South. Double Headed black 5 locomotives...

By: pauluksteam

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20140510140318 - Highlands and Islands Explorer Arrives into Perth - Video

Marines establish beachhead on Roi-Namur, Marshall Islands during Pacific Campaig…HD Stock Footage – Video

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Marines establish beachhead on Roi-Namur, Marshall Islands during Pacific Campaig...HD Stock Footage
Link to order this clip: http://www.criticalpast.com/video/65675052298_Marines_ruins_wreckage-of-Japanese-G4M-plane_beachhead_black-smoke Historic Stock Footage Archival and Vintage Video Clips...

By: CriticalPast

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Marines establish beachhead on Roi-Namur, Marshall Islands during Pacific Campaig...HD Stock Footage - Video

Brooks wins Madeira Islands playoff; caddie's death mars finish

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Brooks wins Madeira Islands playoff; caddie's death mars finish

Daniel Brooks wins fog-shortened Madeira Islands Open in playoff

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SANTO DA SERRA, Madeira Islands --Daniel Brooks made par on the first playoff hole Sunday to win the fog-shortened Madeira Islands Open, which was overshadowed by the death of a caddie earlier in the day.

Scott Henry, who had birdied the last three holes to force a playoff, three-putted for bogey on the first extra hole to finish second.

However, some European Tour members said the tournament should have been stopped after Ian MacGregor, the 52-year-old Zimbabwe-born caddy to Scotland's Alastair Forsyth, collapsed and died of an apparent heart attack on the ninth fairway -- Forsyth's final hole.

The event, which had already been shortened to 36 holes because of a series of fog delays, was halted again after the delay but restarted following a minute's silence.

"Can't believe they are going to keep playing in Madeira," Pablo Larrazabal, who was not in the tournament, wrote on Twitter. "Life is more important than golf."

France's Jean-Baptiste Gonnet, who missed the first-round cut, also wrote: "There is no respect anymore. How you can even walk on the 9th fairway."

However, European Tour officials said they had consulted with players and caddies before deciding to play on. Forsyth said it was the right decision.

"I felt that was what Mac would have wanted," Forsyth said. "He was a guy I've known for 15 years and he was very popular amongst the caddies. Obviously my thoughts go out to his family. For something like that to happen so suddenly is so sad. He's far too young and he had no problem carrying bags around a golf course so I didn't see an awful lot wrong with him.

"He was the life and soul of the caddies' lounge, a good laugh and nice guy. I'm absolutely numb."

Brooks shot a 5-under 67 to sit tied with Henry (68) at 9-under 135 after the second and final round.

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Daniel Brooks wins fog-shortened Madeira Islands Open in playoff

Brooks wins somber Madeira Islands after a caddie dies

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Updated MAY 12, 2014 3:24a ET

SANTO DA SERRA, Madeira Islands

Daniel Brooks made par on the first playoff hole Sunday to win the fog-shortened Madeira Islands Open, which was overshadowed by the death of a caddie earlier in the day.

Scott Henry, who had birdied the last three holes to force a playoff, three-putted for bogey on the first extra hole to finish second.

However, some European Tour members said the tournament should have been stopped after Ian MacGregor, the 52-year-old Zimbabwe-born caddy to Scotland's Alastair Forsyth, collapsed and died of an apparent heart attack on the ninth fairway -- Forsyth's final hole.

The event, which had already been shortened to 36 holes because of a series of fog delays, was halted again after the delay but restarted following a minute's silence.

"Can't believe they are going to keep playing in Madeira," Pablo Larrazabal, who was not in the tournament, wrote on Twitter. "Life is more important than golf."

France's Jean-Baptiste Gonnet, who missed the first-round cut, also wrote: "There is no respect anymore. How you can even walk on the 9th fairway."

However, European Tour officials said they had consulted with players and caddies before deciding to play on. Forsyth said it was the right decision.

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Brooks wins somber Madeira Islands after a caddie dies

Atlas shows how genes affect our metabolism

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PUBLIC RELEASE DATE:

11-May-2014

Contact: Mark Thomson press.office@sanger.ac.uk 01-223-492-384 Wellcome Trust Sanger Institute

In the most comprehensive exploration of the association between genetic variation and human metabolism, researchers have provided unprecedented insights into how genetic variants influence complex disease and drug response through metabolic pathways.

The team has linked 145 genetic regions with more than 400 molecules involved in human metabolism in human blood. This atlas of genetic associations with metabolism provides many new opportunities to understand the molecular pathways underlying associations with common, complex diseases.

Metabolic molecules, known as metabolites, include a wide range of different molecules such as vitamins, lipids, carbohydrates and nucleotides. They make up parts of, or are the products of, all biological pathways. This new compendium of associations between genetic regions and metabolite levels provides a powerful tool to identify genes that could be used in drug and diagnostic tests for a wide range of metabolic disorders.

"The sheer wealth of biological information we have uncovered is extraordinary," says Dr Nicole Soranzo, senior author from the Wellcome Trust Sanger Institute. "It's exciting to think that researchers can now take this freely available information forward to better understand the molecular underpinnings of a vast range of metabolic associations."

The team measured the levels of a large number of metabolites, both those already known and many as yet uncharacterised, from many different metabolic pathways.

They found 90 new genetic associations, trebling the figure of known genetic associations with metabolites. In many of the cases where metabolites were known, the team were able to link the molecule to gene function. They mapped genes to their likely substrates or products and linked these to a number of conditions, including hypertension, cardiovascular disease and diabetes.

They further found that these genetic regions map preferentially to genes that are currently targeted in drug-development programmes. This provides new opportunities to assess genetic influences on drug response, and to assess the potential for existing drugs to treat a wide range of diseases.

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Atlas shows how genes affect our metabolism