Supermicro Announces Storage Solutions Optimized for Extreme Scale-Out …

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Red Hat Inktank Ceph Ready 42U Rack, Monitor, Object Storage Servers with 10GbE Networking Deliver Complete, Rapid Deployment Scale-Out Storage Solutions

SAN JOSE, Calif. - Super Micro Computer, Inc. (NASDAQ: SMCI), a global leader in high-performance, high-efficiency server, storage technology and green computing announces complete server and storage rack solutions configured with Inktank Ceph this week at the OpenStack Summit in Atlanta, May 12-16. Inktank was acquired by Red Hat in April 2014. Supermicro's 42U rack object-based storage clusters feature end-to-end 10GbE interconnectivity across triple redundant 1U Monitor nodes and compute/capacity balanced 3.5" HDD/SSD storage servers in 2U 12x bay, 4U 36x bay and 4U 72x bay configurations. The complete cluster solution is engineered to handle extreme scale-out storage applications with maximum performance and reliability to meet the most stringent SLAs. Fully populated rack solutions make it easy for cloud providers to rapidly implement and scale with consistent rack-to-rack layouts, simplifying the maintenance and management of multi-petabyte storage deployments.

"With Internet and Cloud expansion generating massive amounts of unstructured data, there is an urgent need for extremely scalable, manageable and cost effective storage solutions that go beyond the scope of today's ordinary storage solutions," said Charles Liang, President and CEO of Supermicro. "Our Enterprise class, energy efficient server, storage and networking architecture with the sophisticated data synchronization and balancing capabilities of Inktank Ceph deliver a truly extraordinary solution that addresses these industry growth challenges. Our Ceph-based 1U 4x 3.5" HDD monitor node and 4U 72x HDD/SSD object-based storage servers combined with high-bandwidth 10GbE network interconnectivity maximize performance while delivering the highest density and practically infinite scalability in our fully integrated 42U rack solutions."

"Ceph was developed with the goal to transform deployment, management and maintenance of cloud-scale storage infrastructure," said Ben Cherian, vice president, Strategic Development, at Inktank. "Our open source-based software-defined storage solution is highly scalable and provides world class data protection and performance, all of which can lower the barrier of entry to many organizations in need of hyper dynamic storage pools. Collaborating with Supermicro, we've found an ideal solution partner that can deliver well tuned server and storage platforms that complement our technology and drive to deliver cost-effective high performance storage solutions to mass markets."

Supermicro ready-to-deploy object-based storage solutions are configured, tested and delivered in 42U rack clusters featuring end-to-end 10GbE interconnectivity with a 1U performance optimized Monitor node, 2U or 4U high density, high capacity Object Storage Daemon (OSD) nodes, a 10GbE top-of-rack network switch and out-of-band server management utilities.

Supermicro Clusters and Components

-- 42U SuperRack Cabinet (SRK-42SE-02) -- 42U-320TB (SRS-42E112-CEPH-01) - Integrated Ceph Rack, 3x Mon, 8x 2U OSD, Networking & PDU -- 42U-1.08PB (SRS-42E136-CEPH-01) - Integrated Ceph Rack, 3x Mon, 9x 4U OSD, Networking & PDU -- 42U-2.16PB (SRS-42E172-CEPH-01) - Integrated Ceph Rack, 3x Mon, 9x 4U OSD, Networking & PDU -- Monitor Node (SYS-6017R-MON1) - Single Intel Xeon E5-2630 v2 Processor, 128GB memory, 4x 3.5" hot-swappable 400GB HDDs, dual-port 10G (SFP+) -- 2U 12x HDD/SSD Bay OSD Node (SSG-6027R-OSD040H) - Dual Intel E5-2630 v2 (6-core) Processors, 128GB memory, 2X 400GB SSD, 10x 4TB HDDs, rear 2.5" mirrored 40GB hot-swap OS SSDs, dual-port 10G (SFP+) -- 4U 36x HDD/SSD Bay OSD Node (SSG-6047R-OSD120H) - Dual Intel E5-2630 v2 (6-core) Processors, 128GB memory, 6X 400GB SSD, 30x 4TB HDDs, rear 2.5" mirrored 40GB hot-swap OS SSDs, quad-port 10G (SFP+) -- 4U 72x HDD/SSD Bay OSD Node (SSG-6047R-OSD240H) - Dual Intel E5-2670 v2 (10-core) Processors, 256GB memory, 12X 400GB SSD, 60x 4TB HDDs, rear 2.5" mirrored 40GB hot-swap OS SSDs, quad-port 10G (SFP+) -- 1U Layer 2/3, 1/10GbE Ethernet Switches - 24x (RJ45) 1GbE ports, 4x (CX4, XFP, or SFP+) 10GbE ports (SSE-G24-TG4); 24x (SFP+) 10GbE ports (SSE-X24S / SSE-X3348S(R) -- Supermicro Server Management Software Utilities (www.supermicro.com/SMS) -- Supermicro Onsite Service and Support (www.supermicro.com/OSS)

For more information about Supermicro's Ceph-based Scale-out Storage Solutions, visit http://www.supermicro.com/Storage_Ceph.

About Super Micro Computer, Inc. Supermicro (NASDAQ: SMCI), the leading innovator in high-performance, high-efficiency server technology is a premier provider of advanced server Building Block Solutions for Data Center, Cloud Computing, Enterprise IT, Hadoop/Big Data, HPC and Embedded Systems worldwide. Supermicro is committed to protecting the environment through its "We Keep IT Green" initiative and provides customers with the most energy-efficient, environmentally-friendly solutions available on the market.

Supermicro, SuperRack, Building Block Solutions and We Keep IT Green are trademarks and/or registered trademarks of Super Micro Computer, Inc.

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Stem Cell Therapy Shows Promise for MS in Mouse Model

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Newswise LA JOLLA, CAMay 15, 2014Mice crippled by an autoimmune disease similar to multiple sclerosis (MS) regained the ability to walk and run after a team of researchers led by scientists at The Scripps Research Institute (TSRI), University of Utah and University of California (UC), Irvine implanted human stem cells into their injured spinal cords.

Remarkably, the mice recovered even after their bodies rejected the human stem cells. When we implanted the human cells into mice that were paralyzed, they got up and started walking a couple of weeks later, and they completely recovered over the next several months, said study co-leader Jeanne Loring, a professor of developmental neurobiology at TSRI.

Thomas Lane, an immunologist at the University of Utah who co-led the study with Loring, said he had never seen anything like it. Weve been studying mouse stem cells for a long time, but we never saw the clinical improvement that occurred with the human cells that Dr. Loring's lab provided, said Lane, who began the study at UC Irvine.

The mices dramatic recovery, which is reported online ahead of print by the journal Stem Cell Reports, could lead to new ways to treat multiple sclerosis in humans.

"This is a great step forward in the development of new therapies for stopping disease progression and promoting repair for MS patients, said co-author Craig Walsh, a UC Irvine immunologist.

Stem Cell Therapy for MS

MS is an autoimmune disease of the brain and spinal cord that affects more than a half-million people in North America and Europe, and more than two million worldwide. In MS, immune cells known as T cells invade the upper spinal cord and brain, causing inflammation and ultimately the loss of an insulating coating on nerve fibers called myelin. Affected nerve fibers lose their ability to transmit electrical signals efficiently, and this can eventually lead to symptoms such as limb weakness, numbness and tingling, fatigue, vision problems, slurred speech, memory difficulties and depression.

Current therapies, such as interferon beta, aim to suppress the immune attack that strips the myelin from nerve fibers. But they are only partially effective and often have significant adverse side effects. Lorings group at TSRI has been searching for another way to treat MS using human pluripotent stem cells, which are cells that have the potential to transform into any of the cell types in the body.

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Stem Cell Therapy Shows Promise for MS in Mouse Model

Stem cell therapy shows promise for multiple sclerosis

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In this image, the top row shows the stem cells transplanted into the mouse spinal cord. The lower row shows a close-up of the stem cells (brown). By day 7 post-transplant, the stem cells are no longer detectable. Within this short period of time, the stem cells have sent chemical signals to the mouses own cells, enabling them to repair the nerve damage caused by MS. (image: Lu Chen)

For patients with multiple sclerosis (MS), current treatment options only address early-stage symptoms of the debilitating disease. Now, new research has found a potential treatment that could both stop disease progression and repair existing damage.

In a study published in Stem Cell Reports, researchers utilized a group of paralyzed mice genetically engineered to have an MS-like condition. Initially, the researchers set out to study the mechanisms of stem cell rejection in the mice. However, two weeks after injecting the mice with human neural stem cells, the researchers made the unexpected discovery that the mice had regained their ability to walk.

This had a lot of luck to do with it; right place, right time co-senior author Jeanne Loring, director of the Center for Regenerative Medicine at The Scripps Research Institute in La Jolla, California, told FoxNews.com. [co-senior author Tom Lane] called me up and said, Youre not going to believe this. He sent me a video, and it showed the mice running around the cages. I said, Are you sure these are the same mice?

Loring, whose lab specializes in turning human stem cells into neural precursor cells, or pluripotent cells, collaborated with Tom Lane, a professor of pathology at the University of Utah whose focus is on neuroinflammatory diseases of the central nervous system. The team was interested in stem cell rejection in MS models in order to understand the underlying molecular and cellular mechanisms contributing to rejection of potential stem cell therapies for the disease.

Multiple sclerosis is an autoimmune disease that affects more than 2.3 million people worldwide. For people with MS, the immune system misguidedly attacks the bodys myelin, the insulating coating on nerve fibers.

In a nutshell, its the rubber sheath that protects the electrical wire; the axon that extends from the nerves cell body is insulated by myelin, Lane, who began the study while at the University of California, Irvine, told FoxNews.com

Once the myelin has been lost, nerve fibers are unable to transmit electric signals efficiently, leading to symptoms such as vision and motor skill problems, fatigue, slurred speech, memory difficulties and depression.

The researchers inadvertent treatment appeared to work in two ways. First, there was a decrease of inflammation within the central nervous system of the mice, preventing the disease from progressing. Secondly, the injected cells released proteins that signaled cells to regenerate myelin and repair existing damage.

While the stem cells were rejected in the mice after 10 days, researchers were able to see improvements for up to six months after initial implantation.

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Stem cell therapy shows promise for multiple sclerosis

Succssful Stem Cell Therapy in Monkeys is First of Its Kind

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Mice have been poked, prodded, injected and dissected in the name of science. But there are limits to what mice can teach us especially when it comes to stem cell therapies. For the first time, researchers haveturned skin cells into bone in a creature more closely related to humans: monkeys.

In a study published Thursday in the journal Cell Reports, scientists report that they regrew bone in 25rhesus macaques using induced pluripotent stem cells (iPSCs) taken from the creatures skin. Since macaques are more closely related to humans, their discovery could help push stem cell therapies into early clinical trials in humans.

While this is the good news, the bad news is that iPSCs can also seed tumors in monkeys; however, the tumors grew at a far slower rate than in previous studies in mice. This finding further emphasizes the key role primates likely will play in testing the safety of potential stem cell therapies.

Repairing Bone

Researchers used a common procedure to reprogram macaque skin cells, and coaxed them into pluripotent cells that were capable of building bone. They seeded these cells into ceramic scaffolds, which are already used by surgeons used to reconstruct bone. The cells took, and the monkeys successfully grew new bone.

In some experiments, the monkeys formed teratomas nasty tumors that can contain teeth and hair when they were injected with undifferentiated iPSCs, or cells that have the potential to change into any kind of cell. However, the tumors grew 20 times slower than in mice, highlighting an important difference between mice and monkeys.

Fortunately, tumors did not form in monkeys that were injected with differentiated iPSCs, or cells that were programmed to createbone cells.

Advancing Research

Researchers say their successful procedure proves that monkeys willplay an important rolein research on therapies using iPSCs. These monkeys will help scientists test and analyze risks associated with the therapies and improve their safety.

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Succssful Stem Cell Therapy in Monkeys is First of Its Kind

First test of pluripotent stem cell therapy in monkeys is a success

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PUBLIC RELEASE DATE:

15-May-2014

Contact: Mary Beth O'Leary moleary@cell.com 617-397-2802 Cell Press

Researchers have shown for the first time in an animal that is more closely related to humans that it is possible to make new bone from stem-cell-like induced pluripotent stem cells (iPSCs) made from an individual animal's own skin cells. The study in monkeys reported in the Cell Press journal Cell Reports on May 15th also shows that there is some risk that those iPSCs could seed tumors, but that unfortunate outcome appears to be less likely than studies in immune-compromised mice would suggest.

"We have been able to design an animal model for testing of pluripotent stem cell therapies using the rhesus macaque, a small monkey that is readily available and has been validated as being closely related physiologically to humans," said Cynthia Dunbar of the National Heart, Lung, and Blood Institute. "We have used this model to demonstrate that tumor formation of a type called a 'teratoma' from undifferentiated autologous iPSCs does occur; however, tumor formation is very slow and requires large numbers of iPSCs given under very hospitable conditions. We have also shown that new bone can be produced from autologous iPSCs, as a model for their possible clinical application."

Autologous refers to the fact that the iPSCs capable of producing any tissue typein this case bonewere derived from the very individual that later received them. That means that use of these cells in tissue repair would not require long-term or possibly toxic immune suppression drugs to prevent rejection.

The researchers first used a standard recipe to reprogram skin cells taken from rhesus macaques. They then coaxed those cells to form first pluripotent stem cells and then cells that have the potential to act more specifically as bone progenitors. Those progenitor cells were then seeded onto ceramic scaffolds that are already in use by reconstructive surgeons attempting to fill in or rebuild bone. And, it worked; the monkeys grew new bone.

Importantly, the researchers report that no teratoma structures developed in monkeys that had received the bone "stem cells." In other experiments, undifferentiated iPSCs did form teratomas in a dose-dependent manner.

The researchers say that therapies based on this approach could be particularly beneficial for people with large congenital bone defects or other traumatic injuries. Although bone replacement is an unlikely "first in human" use for stem cell therapies given that the condition it treats is not life threatening, the findings in a primate are an essential step on the path toward regenerative clinical medicine.

"A large animal preclinical model for the development of pluripotent or other high-risk/high-reward generative cell therapies is absolutely required to address issues of tissue integration or homing, risk of tumor formation, and immunogenicity," Dunbar said. "The testing of human-derived cells in vitro or in profoundly immunodeficient mice simply cannot model these crucial preclinical safety and efficiency issues."

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First test of pluripotent stem cell therapy in monkeys is a success

First test of pluripotent stem cell therapy in monkeys is successful

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Researchers have shown for the first time in an animal that is more closely related to humans that it is possible to make new bone from stem-cell-like induced pluripotent stem cells (iPSCs) made from an individual animal's own skin cells. The study in monkeys reported in the Cell Press journal Cell Reports on May 15th also shows that there is some risk that those iPSCs could seed tumors, but that unfortunate outcome appears to be less likely than studies in immune-compromised mice would suggest.

"We have been able to design an animal model for testing of pluripotent stem cell therapies using the rhesus macaque, a small monkey that is readily available and has been validated as being closely related physiologically to humans," said Cynthia Dunbar of the National Heart, Lung, and Blood Institute. "We have used this model to demonstrate that tumor formation of a type called a 'teratoma' from undifferentiated autologous iPSCs does occur; however, tumor formation is very slow and requires large numbers of iPSCs given under very hospitable conditions. We have also shown that new bone can be produced from autologous iPSCs, as a model for their possible clinical application."

Autologous refers to the fact that the iPSCs capable of producing any tissue typein this case bonewere derived from the very individual that later received them. That means that use of these cells in tissue repair would not require long-term or possibly toxic immune suppression drugs to prevent rejection.

The researchers first used a standard recipe to reprogram skin cells taken from rhesus macaques. They then coaxed those cells to form first pluripotent stem cells and then cells that have the potential to act more specifically as bone progenitors. Those progenitor cells were then seeded onto ceramic scaffolds that are already in use by reconstructive surgeons attempting to fill in or rebuild bone. And, it worked; the monkeys grew new bone.

Importantly, the researchers report that no teratoma structures developed in monkeys that had received the bone "stem cells." In other experiments, undifferentiated iPSCs did form teratomas in a dose-dependent manner.

The researchers say that therapies based on this approach could be particularly beneficial for people with large congenital bone defects or other traumatic injuries. Although bone replacement is an unlikely "first in human" use for stem cell therapies given that the condition it treats is not life threatening, the findings in a primate are an essential step on the path toward regenerative clinical medicine.

"A large animal preclinical model for the development of pluripotent or other high-risk/high-reward generative cell therapies is absolutely required to address issues of tissue integration or homing, risk of tumor formation, and immunogenicity," Dunbar said. "The testing of human-derived cells in vitro or in profoundly immunodeficient mice simply cannot model these crucial preclinical safety and efficiency issues."

The NIH team is now working with collaborators on differentiation of the macaque iPSCs into liver, heart, and white blood cells for eventual clinical trials in hepatitis C, heart failure, and chronic granulomatous disease, respectively.

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First test of pluripotent stem cell therapy in monkeys is successful

Spirituality Means Taking Care of Myself: Anita Moorjani, Present Moments – Video

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Spirituality Means Taking Care of Myself: Anita Moorjani, Present Moments
For Weekly Inspiration, knowledge and information like this, Subscribe to the Present Moments Newsletter http://www.hayhouse.com/newsletters/signup Being spiritual means taking care of yourself....

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Thought Leader Gabrielle Bernstein on Finding Spirituality While Wearing High Heels #OWNSHOW – Video

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Thought Leader Gabrielle Bernstein on Finding Spirituality While Wearing High Heels #OWNSHOW
Subscribe to OWN: http://bit.ly/18Lz0rV Watch more #OWNSHOW: http://www.youtube.com/playlist?list=PLFAF0HGlvTj7m6bJO-rpnW-1ywKFQrKbv Gabrielle Bernstein, author of May Cause Miracles, realized...

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Thought Leader Gabrielle Bernstein on Finding Spirituality While Wearing High Heels #OWNSHOW - Video

Disconnected from Nature: Spirituality and Being One with Nature – Nicky Sutton – Video

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Disconnected from Nature: Spirituality and Being One with Nature - Nicky Sutton
Become one with nature for your spiritual development. Most of us live in a concrete habitat, disconnect from nature. Step back during your spiritual awakening and take a look. It #39;s usually...

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Disconnected from Nature: Spirituality and Being One with Nature - Nicky Sutton - Video

How Ignatian Spirituality Can Aid Us in Living Theology of the Body – Video

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How Ignatian Spirituality Can Aid Us in Living Theology of the Body
Here are some of my reflections on how Ignatian Spirituality (Examen Prayer, Rules for Discernment, Meditation/Contemplation, etc.) can help live the Church #39;s beautiful teaching of Theology...

By: Joshua Kingdon

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How Ignatian Spirituality Can Aid Us in Living Theology of the Body - Video

How I Started My Spiritual Journey.. Is Your Spirituality in the Closet? – Video

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How I Started My Spiritual Journey.. Is Your Spirituality in the Closet?
How I became vocal about spirituality and why it #39;s not weird to want to discuss consciousness, yogi philosophy, meditation, enlightenment and desiring a greater meaning in life.

By: Sara Wasabi

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How I Started My Spiritual Journey.. Is Your Spirituality in the Closet? - Video