All Things Go Fall Classic debuts at Union Market

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By Geoffrey Himes September 11

One has to go way back to the years before the Beatles Sgt. Peppers Lonely Hearts Club Band in 1967 to find a time when singles overpowered albums as they do today. Now you only have to look to the All Things Go Fall Classic, an alternative-rock festival at Union Market on Saturday. Three of the top acts Future Islands, Bear Hands and Tove Lo have taken a big leap this year thanks to one particular song going viral.

For Baltimore band Future Islands, that song was Seasons (Waiting on You). After the band performed it on The Late Show With David Letterman in March, the video of lead singer Sam Herring doing his chest-thumping gorilla dance as he achingly sang, Ive been waiting on you became a YouTube sensation and helped lift the song to No. 37 on Billboards alternative songs chart.

For Tove Lo of Sweden, the song was Habits (Stay High). The video of the singer downing gallons of liquor as she tells her ex, I gotta stay high all the time to keep you off my mind helped propel the song to No. 20 on the same chart. And for Brooklyn-based Bear Hands, it was Giants. The videos jittery editing of writhing, scantily clad women echoed the contrast between the staccato, angst-ridden verses and the more optimistic, hook-laden refrain, I am loving you more. That tension elevated the tune to No. 8.

More than ever, people are consuming music one song at a time, says Bear Hands guitarist and producer Ted Feldman. There are a million artists in the world. Theres only so much time, and all those artists are competing for everyones ears. So its far more likely that one song will grab those ears than a whole album. You hope that that one song is a foot in the door that gets you more attention.

Thats the world we live in, agrees Will Suter, one of the four founders of All Things Go, a Washington-based music Web site that has evolved into a major live-music promoter. People have shorter attention spans now. Theyll fall in love with one song, and theyll listen to that over and over again. The new Future Islands album is called Singles for a reason they get it.

The renewed emphasis on one breakthrough song has created a conundrum for the alternative rock that All Things Go emphasizes on its Web site and is featuring in its first music festival. How can you create a sound unlike usual rock and also connect with a large audience? Or develop a multifaceted personality through multiple songs when many listeners know you for only one song?

Feldman refuses to accept such either/or premises.

I dont really understand people who say they dont care what the audience thinks, he says by phone from the road. Were not writing to the lowest common denominator, but we do want to connect with an audience who can get the song from top to bottom. No one wants to hear a song that they can guess how the rest of it goes the first time they hear it. We want to join the cultural conversation by speaking the common language, but we want to add something new.

Giants began as so many Bear Hands songs do with lead singer Dylan Rau improvising lyrics to a simple drum-and-keyboard loop. But there was something about this effort that got the quartet excited.

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All Things Go Fall Classic debuts at Union Market

The Virgin Islands, Rewritten

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Credit Photograph by Christian Heeb/laif/Redux

When I moved to the U.S. Virgin Islands after college, for a job at a local newspaper, everyone I met told me that I had to read Herman Wouks Dont Stop the Carnival. It was the best novel ever set in the Virgin Islands. The funniest. Wouk, people said, gets island life exactly right. Never mind that no one north of the eighteenth parallel had heard of the book. You could find copies for sale in virtually every gift shop and bookstore from Tortola to Grenada. I found a tattered hardcover in the newspapers office and finished it in a day or two. It was dated, but a fun read.

Wouk, the author of The Caine Mutiny and Marjorie Morningstar, lived on St. Thomas from 1958 until 1964. (He is now ninety-nine.) He moved to the island to escape the distractions of New York City. While there, in his big house on a hill, he started writing The Winds of War, a major novel about the Second World War. He also made time to write something lighter. Dont Stop the Carnival, published in 1965, is a zippy farce about a Broadway press agent and self-described good New York liberal, Norman Paperman, who sees an ad in The New Yorker listing a funky Caribbean hotel for sale, flies south, and buys it. A large cast of eccentrics surrounds Paperman and drives the mostly slapstick narrative. His vision of paradise (green hills, snowy sand, azure sea) is soon crowded off the page by baroque catastrophe (scheming contractor, bursting cistern, island bureaucracy). Racism, intolerance, imperialism, cronyism, and alcoholism become the leitmotifs. Characters start getting killed. Paperman sells the hotel as quickly as he bought it and flees back to New York.

For Tiphanie Yanique, who is from St. Thomas, Dont Stop the Carnival was not a fun read. Her dbut novel, Land of Love and Drowning, which came out this summer, was written partly as an answer to Wouk. As she said in a recent interview, Virgin Islanders dont really give the book much thought. We dont think its a good representation of who we are. And yet this was the book being marketed as a credible anthropological text. The Virgin Islanders in the book are buffoons. I wanted to write something that people would say, If youre going to read the Herman Wouk, you have to also read the Yanique. For a writer from the Virgin Islands, there was, apparently, no escaping the shadow cast by Wouks beach umbrella.

Land of Love and Drowning is a completely different type of novel. Its a multigenerational saga about an island family, dramatizing historical events and salted with magical realism: one woman has hooves for feet, another has glittering silver pubic hair. But Yanique takes characters and settings from Wouks book and subversively reimagines them. A hotel cook, Sheila, gets a last name and an inner life. A talented but violent handyman named Hippolyte reappears, now more the holy fool, less the dangerous lunatic. The hotel itself gets a major moral facelift. It is now the touchstone for Yaniques characters jaundiced views of land development on their islands, and of the obnoxious, greedy, and debauched continentals who arrive in ever larger numbers. As far as we could see, thats all the Americans seemed to dodrink rum and buy up land, Anette Bradshaw, a history teacher, observes.

The two novels converge on the same incidents, from opposite angles. At the hotelcalled, in both books, the Gull Reef Clubone of Papermans recurring headaches involves negotiations over the immigration status of his employees. A bureaucrat threatens to deport his best chambermaid. Yanique uses this Woukian plot thread to show the new form of racism that Virgin Islanders increasingly confronted when continentals showed up and built houses, hotels, and golf courses across St. Thomas. Anette Bradshaw is walking home from the airport with her children. A big car full of Americans pulls up, with a white man and a white woman in the front seat. The driver says that he owns the Gull Reef Club. Were looking for a chambermaid. Ours, it seems, has just been deported back to Antigua or Anguilla or somewhere. You can imagine were in a bind. If youre free, we could take you right now, tykes and all. If Anette was not at present in mourning she might have done the fiery thing reach over the driver, and slap the woman in the face. A woman should have known better than to allow such an insult in front of the children.

Land of Love and Drowning is also, according to an authors note, a response to a soft-porn film called Girls Are for Loving, which was shot in the Virgin Islands in the nineteen-seventies. The film crew employed local people as extras, Yanique writes, but did not inform them of the films sexual content. In the novel, the films local scenes, primarily dancing, are shot at the Gull Reef Club. Anette and her husband, Franky, are among the extras. Anette senses that something is amiss, but ignores the signs. Months later, when Girls Are for Loving premires on the island, she and Franky dress up and join an excited crowd of islanders at the local theater. In the film, they see their own faces, and Anettes red skirt flying, accompanied by African drumming, intercut with shots of a white couple kissing and, soon enough, copulating. The audience is horrified. Then the pastors wife scream in the theater like she bout to dead. And all the people in the theater start to flood out. We spill out into the street but cant look at each other. This how we get put on the map in America? This me and my husband debut to the island and the nation? Is what they call pornographic. You hearing me.

We do hear Anette, loud and clear. She narrates some of the novels best passages in a dialect that is both inventive and fluid. Describing the day in 1917 when the islands of St. Thomas, St. John, and St. Croix were transferred from Danish to American rule, she says, Denmark decide it dont want we. America decide it do. One find we unnecessary because they way up in Europe. The next find we absolutely necessary because they backside sitting on the Caribbean. I wish Yanique had written more of the novel in that voice. Instead, she jumps erratically from one characters mind to the next, in a way that can feel unbalanced. Perhaps that was her aim. Yanique makes it clear from the beginning that she is not interested in the framing and cornicing of realism. History is a kind of magic I doing here, Anette says. Yanique, meanwhile, brings the natural world of the Virgin Islands into high relief, with similes that seem to erupt effortlessly from the lushness of her prose. Boys will stick to the younger sister like the slick of mango juice. A trinity of men will feel the love of her like casha bush burring their scalp in sleep.

I lived on St. John. It was a small island, very beautiful, quite segregated. Soon after I arrived, there was a rash of violent crimesassault, vandalism, alleged rape, arsonwith a toxic racial element. A white furniture-store owner known as Bali Bob ended up going to prison for assault and battery. Our little newspaper struggled to cover these stories. There was nothing slapstick about any of it. For an outsider, it was impossible to know much about the long, gnarled, local history of racial insult, stratification, and conflicta history kept largely through oral transmission by island families. Yanique brings reams of this spoken lore to the page. The ladys right: if youre going to read the Wouk, you also have to read the Yanique.

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The Virgin Islands, Rewritten

Google Continues To Build Upon Its Life Sciences Ecosystem

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Google has a mission to organize the worlds information and make it accessible to everyone. The companyis mostly known for its search engine and the largest mobile operating system, but you may not be aware that Google is also heavily involved in the life sciences sector. Google has invested in a number of biotech and life science companies through its venture capital arm, Google Ventures.

Lift Labs

Yesterday, Google acquired Lift Labs. Lift Labs is a company that has built a high-tech device handle, which can stabilize what is being held using an attachable spoon or fork. This type of device benefits someone that has Parkinsons Disease or Essential tremor (ET). The Lift Labs team is joining the Life Sciences division at Google[x], which is a skunkworks lab led by Google co-founder Sergey Brin.

DNAnexus

DNAnexus is a DNA sequencing data software company that works with several genome sequencing organizations to better understand human genetics contributing to heart disease and aging.Last year, DNAnexus partnered with Baylor College of Medicine to process 3,751 whole human genomes and 10,771 exomes. DNAnexus uses Amazon Web Services cloud computing to sequence DNA data and store it.GoogleVentures invested in DNAnexus$15 million Series B and $15 million Series C round of funding.

Rani Therapeutics

Google Ventures participated in an undisclosed Series B round for Rani Therapeutics in August 2013. Rani Therapeutics is working on developing technology for the oral delivery of large drug molecules, which are delivered through injections.Rani Therapeutics is currently in pre-clinical studies and demonstrated over 50% bioavailability.

SynapDx

SynapDx is a company that provides laboratory testing services to physicians who work with children that have development disorders. The goal is to enable earlier detection of autism. In July 2013, Google participated in a $15.4 million round of funding for SynapDx.

One Medical Group

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Center to Find Drug Combinations that Reduce Side Effects

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Newswise (New York, NY Sept. 11, 2014) A research team from the Icahn School of Medicine at Mount Sinai today received a $12 million grant from the National Institutes of Health to create a center that will screen massive data sets for new uses of existing drugs, and confirm them in human cell tests. The centers first mission will be to find FDA-approved drugs that reduce side effects when paired with hundreds of leading drugs against common, deadly diseases.

With advances in inexpensive computing power, and stored data collections becoming truly massive in the era of big data, researchers are just now able to design algorithms and models that pull previously unrecognized disease and drug treatment patterns from databases. These computational patterns are predictive, and researchers can validate them with experiments.

The goal of our new center is to detect changes made in human heart, liver and nerve cells as otherwise useful drugs cause side effects, and to find the combinations of existing drugs that reduce these side effects, said Ravi Iyengar, PhD, the Dorothy H. and Lewis Rosenstiel Professor in the Department of Pharmacology and Systems Therapeutics within the Icahn School of Medicine at Mount Sinai, and the lead investigator for the center grant.

Our center embodies a third way to reduce the side effects that limit the use of so many treatments, along with two traditional approaches: fine-tuning a drugs chemical structure or tailoring its use for each individuals genetics, he added.

Hidden Signatures The new grant will fund a Drug Toxicity Signature Generation Center at Mount Sinai as part the NIH Common Funds LINCS program, the Library of Integrated Network-based Cellular Signatures program. Each signature is a confirmed set of genetic and protein responses within a type of cell to a drug or drug combination.

The team will find such signatures by combining high-throughput experiments on cell responses to drugs with statistical analyses of side effect, gene and protein interaction databases. Interestingly, the team starts with stem cells and then converts them into the heart, liver and nerve cells used in the experiments. The new centers goal is to generate 2,000 signatures per year for further testing.

To anchor the signatures to human diseases and treatments, the team will search the U.S. Food and Drug Administrations Adverse Event Reporting System (FAERS) database to find cases where adding a second drug reduced the side effects associated with a commonly used primary treatment. FAERS has for decades collected such data from individuals, health professionals, drug companies and hospitals, and the millions of records on patients taking multiple drugs now in this public database are free and open to all researchers for analysis.

To translate FAERS-generated drug combinations that reduce toxicity into networks of mechanism-based cell response signatures, the team will then run the experimental results through other databases, including NIH databases of human DNA sequences and interactions between proteins. These networks will be filtered using sophisticated modeling techniques to increase the reliability of the signatures. The most promising signatures can then form the basis for targeted animal and human clinical studies on drug repurposing.

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Advocate Health Care and NorthShore to merge

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Two of Chicago's largest hospital systems on Thursday approved plans to combine, creating a 16-hospital, $6.8 billion system that promises to change the competitive landscape of health care in the Chicago region.

Advocate Health Care, the state's largest hospital system, and NorthShore University HealthSystem, the dominant hospital chain in the North Shore suburbs, said Thursday they will merge to create Advocate NorthShore Health Partners in a deal that's expected to close in early 2015.

The blockbuster deal is the largest hospital merger in Illinois in recent years, a trend set in motion by the federal Affordable Care Act and fueled in part by declining hospital patient volume and tighter finances.

It will create the 11th-largest nonprofit health system in the country and by the far the largest in Illinois, with more than 45,000 employees and 4,438 hospital beds.

"This is a huge win for Advocate. It's an incredible coup to lock up NorthShore. It's a great market and it's a great system," said Jordan Shields, a vice president at Juniper Advisory, a Chicago-based investment bank that provides merger and acquisition services to hospital systems.

The deal, Shields said, "is going to shake people. What this does is change the gravity in the metropolitan area."

Combined, the new health system will serve an estimated 3 million patients a year at more than 350 facilities including hospitals, clinics, doctors' offices and outpatient centers.

Both health systems' boards voted unanimously this week to approve the deal, which also will unite two of the region's largest medical groups, giving Advocate NorthShore more than 2,000 employed physicians.

The deal still requires approval from the United Church of Christ, which is affiliated with Advocate; the Federal Trade Commission; and state regulators.

Under terms of the merger, both health systems will contribute six members of a 12-member board of directors. Jim Skogsbergh, president and chief executive officer of Advocate, and NorthShore CEO Mark Neaman will be co-CEOs of the combined enterprise.

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Advocate Health Care and NorthShore to merge

The Wall Street Journal: Health-care rebounds as Obamacare provides a boost

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The sprawling U.S. health-care industry saw revenue rebound last quarter, a sign that stronger spending at hospitals and medical offices could help boost U.S. economic growth to its highest level in eight years.

Total revenue at health-care and social-assistance firms rose 3% in the second quarter from the first three months of the year, the Commerce Department said Thursday in its Quarterly Services Survey. Hospital revenue rose 2.8% from the first quarter and revenue at physician offices jumped 4.1%.

Thursdays report showed modest acceleration in health spending in the second quarter, driven likely by both more people insured under the Affordable Care Act and the recovering economy putting some upward pressure on health-care costs, said Larry Levitt, a senior vice president at the Kaiser Family Foundation.

Economists have predicted the rollout of the Affordable Care Act this year will lead to higher health-care spending as millions of Americans obtain insurance coverage and begin using it. The Centers for Medicare and Medicaid Services last week projected health-care spending would grow 5.6% this year, up from an estimated 3.6% in 2013.

But that spending surge didnt materialize in the first quarter, when revenue at health-care and social-assistance firms fell 2% from the fourth quarter. U.S. spending on health-care services, adjusted for inflation, fell at a 1.4% pace and dragged down overall economic growth, the Commerce Department estimated.

Consumer spending generates more than two-thirds of U.S. economic output, and stronger spending on health care and other services should bolster overall growth. The Commerce Department last month said gross domestic product expanded at a 4.2% seasonally adjusted annual rate in the second quarter, rebounding from an unexpected first-quarter contraction.

An expanded version of this report appears at WSJ.com.

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Stocks end mixed; health care stocks slump

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NEW YORK A sluggish September continued for U.S. stocks as investors assessed the outlook for interest rates, the latest sanctions against Russia and volatile energy prices.

Stocks ended the day mixed after gains for dividend-rich utilities stocks largely offset a slump in health care companies. Lululemon, the high-end yoga apparel maker, surged after reporting earnings that surpassed analyst's forecasts.

The stock market has had a slow start to the month, and the Standard & Poor's is on track to end the week with a loss for the first time in six weeks. Investors are struggling to find an impetus to push prices higher with the market close to all-time highs.

"The market might just be pausing here to digest and see what we have to propel it one way or the other," said Jeff Morris, head of U.S. equities at Standard Life Investments.

The Standard & Poor's 500 index rose 1.76 points, or 0.1 percent, to 1,997.45. The Dow Jones industrial average dropped 19.71 points, or 0.1 percent, to 17,049. The Nasdaq composite rose 5.28 points, or 0.1 percent, to 4,591.81.

Stocks started the day lower, led by a big decline for energy stocks as the price of oil extended its declines from a day earlier. Oil futures turned higher throughout the morning as traders judged that new sanctions against Russia over its involvement in Ukraine might crimp supplies. As oil prices rebounded, so did energy stocks.

The price of oil rose $1.16 to close at $92.83 a barrel on the New York Mercantile Exchange, after dropping close to $90 a barrel in early trading.

The stock market gains were led by utilities, which climbed 0.9 percent.

Health care stocks fell the most, declining 0.3 percent.

The industry has been the best-performing sector this year, climbing 15.5 percent, compared to a gain of 8.1 percent for the broader index.

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Stocks end mixed; health care stocks slump

Health Care REIT Boosts Liquidity; Guides 2H14 Buyouts – Analyst Blog

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Health Care REIT, Inc. ( HCN ) disclosed the offering of 15.5 million common shares to strengthen its liquidity position. The company also provided underwriters a 30-day option to buy additional common shares of up to 2.3 million.

To be particular, Health Care REIT expects to use the generated proceeds from this offering to pay off advances under its main unsecured credit facility as well as meet investment needs in health care and seniors housing assets. The Goldman Sachs Group, Inc. ( GS ) and RBC Capital Markets of Regal Beloit Corporation ( RBC ) assisted this real estate investment trust (REIT) in this public offering.

For Health Care REIT, whose cash and cash equivalents stand at $207.4 million as of Jun 30, 2014, the payment of debt is encouraging, as it would reduce interest expenses. However, the dilutive effect of this offering on the shares cannot be avoided. Nevertheless, strategic investments will help Health Care REIT to enhance its portfolio quality, which in turn will boost its top-line growth going forward.

In view of this, on a separate development, Health Care REIT stated its projected acquisition pipeline of around $1.7 billion of properties for the second half of 2014. This was based on the acquisition completed in the third quarter and deals inked so far. Notably, the figure includes previously declared major buyouts of Gracewell Health Care business with Sunrise Senior Living; and HealthLease Properties REIT. The move was aimed at strengthening the company's focus on high-barriers-to-entry affluent markets around the world.

Health Care REIT currently carries a Zacks Rank #3 (Hold). Omega Healthcare Investors Inc. ( OHI ) is a better-ranked REIT having a Zacks Rank #2 (Buy).

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Primary care doctors reluctant to provide genetics assessment in routine care

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Primary care providers report many challenges to integrating genetics services into routine primary care, according to research published today in Genetics in Medicine.

Medical genetics medicine has traditionally been used to identify and diagnose rare diseases, but in the last decade it has been increasingly helpful in determining patients at risk for genetically-based conditions who can benefit from preventive health care, says the study's senior author, Beth Tarini, M.D., M.S., F.A.A.P., assistant professor of pediatrics at the University of Michigan Medical School and C.S. Mott Children's Hospital.

"Genetics is not just about rare diseases and specialists. PCPs rely on genetics frequently during preventive care visits -- especially when taking family histories and assessing a patient's risk of more common, but chronic, diseases. So the fact that PCPs report many barriers to embracing and performing these tasks is concerning, " says Tarini, who is also an investigator at U-M's Child Health Evaluation & Research (CHEAR) Unit and co-medical director of the Genetics in Primary Care Institute (GPCI), a project of the American Academy of Pediatrics

Tarini and her co-investigators conducted a systematic literature review to assess reported barriers from primary care physicians across multiple practice settings, including pediatrics, family medicine, and obstetrics-gynecology.

Primary care physicians most frequently reported that their knowledge and competence related to genetic medicine is insufficient, according to the study.

Other barriers mentioned most often included a lack of knowledge about genetic risk assessment, concern for patient anxiety, a lack of access to genetics, and a lack of time.

"Shedding light on remaining challenges and misperceptions that physicians continue to experience related to genetic medicine in the primary care setting can provide opportunities for intervention in order to improve the delivery of care," says the study's lead author Natalie A. Mikat-Stevens, M.P.H., project manager for the Genetics in Primary Care Institute at the American Academy of Pediatrics.

Tarini says it is not surprising that primary care physicians cite lack of knowledge most frequently.

"Advances in genetic technology and the discovery of new genetic mechanisms seem to occur almost daily. A PCP's genetics training may be decades old and rusty from lack of use," says Tarini, who is also a member of U-M's Institute for Healthcare Policy and Innovation. "Genetics has historically been viewed as a discipline focused on rare conditions, but recent genomic advances have highlighted that genetics has a role in common conditions encountered in primary care medicine."

Tarini and her co-authors urge that efforts are focused on helping primary care physicians address and overcome these barriers.

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Dartmouth research links genetic mutation and melanoma progression

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11-Sep-2014

Contact: Robin Dutcher 603-653-9056 The Geisel School of Medicine at Dartmouth

Dartmouth researchers have found that the genetic mutation BRAFV600E, frequently found in metastatic melanoma, not only secretes a protein that promotes the growth of melanoma tumor cells, but can also modify the network of normal cells around the tumor to support the disease's progression. Targeting this mutation with Vemurafenib reduces this interaction, and suggests possible new treatment options for melanoma therapy. They report on their findings in "BRAFV600E melanoma cells secrete factors that activate stromal fibroblasts and enhance tumourigenicity," which was recently published in British Journal of Cancer.

Authors of the study are Dr. Chery A. Whipple, research associate at the Geisel School of Medicine at Dartmouth, and Dr. Constance Brinckerhoff, professor of Medicine and of Biochemistry at Geisel and member of Dartmouth-Hitchcock Norris Cotton Cancer Center.

"This work supports the importance of the tumor cells "talking" with the normal cells present in the tumor microenvironment," said Whipple, first author on the study. "Targeting the tumor cells with specific therapy to reduce the secreted proteins can reduce the aggressive behavior of the tumor and inhibit disease progression."

Melanoma, the most lethal form of skin cancer, is responsible for more than 80 percent of all skin cancer deaths and spreads readily to the lymph nodes and other organs. While early stage melanoma is curable, the later vertical growth phase (VGP) is frequently metastatic, with median survival times of less than nine months. Melanoma that progresses to this stage is often associated with the gene mutation BRAFV600E, which is found in about 50 percent of melanomas. This BRAF mutation activates certain enzyme pathways that are involved in many cell processes.

Using genetically engineered melanoma cell lines and xenograft mouse models, the Dartmouth researchers found that BRAFV600E melanoma cells expressed higher levels of several cytokines (proteins that act on the immune system and can be used to help the body fight cancer) and Matrix Metalloproteinase-1 (MMP-1; MMPs are associated with various processes including tissue repair and metastasis). Their study also suggests a mechanistic link between BRAFV600E and MMP-1 that modifies the network of normal cells surrounding melanoma tumors, making these "normal cells" more supportive of tumor growth and development. Vemurafenib, a therapeutic drug that specifically targets the BRAFV600E mutation, is able to reduce the expression of several proteins essential for activating this interaction.

"Given that our data show that Vemurafenib is able to reduce the expression of several proteins that are essential for activating the tumor microenvironment (TME), a next step would be to ask whether Vemurafenib normalizes the TME, or keeps it from becoming activated," said Whipple. "If so, does it create a window of time where we could target the TME, normalize it, and enhance the patient's therapeutic response?"

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Dartmouth research links genetic mutation and melanoma progression

Shaking Science with style from IMGGE University of Belgrade, Serbia – Video

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Shaking Science with style from IMGGE University of Belgrade, Serbia
Shaking Science with style made by the Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, Belgrade Serbia Video made for the Competition The Art of Shaking...

By: The Art of Shaking by Kuhner Shaker

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Shaking Science with style from IMGGE University of Belgrade, Serbia - Video