Sareum in psoriasis drug breakthrough

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A transatlantic collaboration between scientists at Sareum in Cambridge UK and colleagues at the US research institute SRI International, holds potential for a novel psoriasis therapy.

They have developed a novel molecule that significantly decreases psoriasis pathology in a disease model a breakthrough reported in the latest edition of the Journal of Immunology.

The potential psoriasis therapy targets members of the JAK family of kinase enzymes, which control the production of cytokines. Cytokines are signalling molecules produced by the immune system, usually in response to a danger such as invading pathogens.

Cytokines responsible for psoriasis are thought to be controlled by JAK family kinases TYK2 and JAK1. Autoimmune diseases, such as psoriasis, can occur when the production of cytokines is not properly regulated and immune cells are overly activated.

In the psoriasis model system, the TYK2/JAK1 inhibitor molecule, known as SAR-20347, interrupted the psoriatic cascade of events and led to reduced activation of keratinocytes (skin cells that multiply excessively in psoriasis) and a reduction of pro-inflammatory cytokine levels.

Sareum and SRI International entered into a co-development agreement to develop TYK2 inhibitors for autoimmune and inflammatory diseases in April 2013.

Sareum's CEO Dr Tim Mitchell, said: The work reported in this publication exemplifies the success of the collaboration and the quality of research by the scientists involved. I look forward to discussing these latest advances with potential licensing partners.

Annalisa D'Andrea, senior director of Center for Immunology and Infectious Diseases in SRI's Biosciences Division, added: While we are still in the early stages of research, our success so far is encouraging, and we plan to pursue other autoimmune and inflammatory diseases that might be treated by TYK2 inhibition.

We hope to expand our TYK2-inhibitor program to address other autoimmune diseases, such as sepsis, rheumatoid arthritis and multiple sclerosis.

AIM-listed Sareum is a drug discovery and development company delivering targeted small molecule therapeutics, focusing on cancer and autoimmune disease, for licensing to pharmaceutical and biotechnology companies at the pre-clinical or early clinical trials stage.

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Sareum in psoriasis drug breakthrough

Nobel laureates summit cancelled after visa denial to Dalai Lama

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The World Summit of Nobel Peace Laureates in Cape Town, South Africa, this month has been cancelled owing to denial of a travel visa by the host country to Tibetan spiritual leader the Dalai Lama, a visiting Nobel laureate said here Wednesday.

"The venue of the summit has been shifted out of South Africa," Nobel Peace Laureate Jody Williams of the US told reporters here.

The new venue for the summit would be announced later, she said.

Williams is in this northern Indian hill town along with fellow laureate Shirin Ebadi of Iran to grace the Dalai Lama's Nobel silver jubilee anniversary celebrations scheduled for Oct 2.

"We feel proud that the summit has been cancelled after we lodged protest over denial of visa to the Dalai Lama," she said.

"Even other Nobel laureates have lodged their protest over the issue," Williams added.

Lobsang Sangay, Prime Minister of Tibetan government in exile, said the new venue of the summit would be announced later.

Ebadi even questioned Archbishop Desmond Tutu's silence on the issue. "I am surprised over the stoic silence of Desmond Tutu. I know he is not part of the government but he's not making his views public," Ebadi said.

"Let's not forget whosoever decides to stay silent against the dictator government is contributing to the dictatorship," she added.

Coming out in support of the Tibetan government-in-exile's cause, Ebadi said: "I am here to learn from His Holiness, who has been leading a non-violent struggle for over 50 years. I hope, someday, I will be talking to you in free Tibet."

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Nobel laureates summit cancelled after visa denial to Dalai Lama

The 16 lessons every traveller learns

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Ben Groundwater Oct 1 2014 at 12:37 AM

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It's a big wide world out there. A scary world. A world filled with dodgy taxi drivers and bad food, dirty hostels and shady locals.

When you first step out into that big world it can be a little daunting, but as time goes by and you settle into the travel scene, you very quickly begin to love it. And that's because every traveller learns certain lessons, lessons about themselves, about travel, and about the world in general. Lessons like these.

You're far more resourceful than you think

This. This is the number one thing every traveller soon realises. You might have previously thought you'd struggle with the language barrier, or that you're terrible with directions, or that you're shy around new people, or that you can't cope in a crisis, but once you throw yourself in the deep end and have to survive on your own in the world, you'll come to know: you're far better at this stuff than you ever realised.

You can get used to pretty much anything in about three days

Every time I go camping, or stay in a hostel, or even eat dodgy street food, the feeling is the same on that first day: urgh. I can't get clean. There are people making noise in my room. This food is going to poison me. But after about three days of anything any level of discomfort, of grot or grime you just get used to it. And then it becomes fun.

You can survive with less food and less sleep than you thought

Couldn't find anywhere to have breakfast this morning? No worries. Stayed up all night boozing and now you have to catch a bus? She'll be right. Blew your budget on a dumb souvenir and now you have to survive on packet noodles? No dramas. See the point above it'll take about three days to get used to it.

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The 16 lessons every traveller learns

Here's What The 2015 Aston Martin Lagonda Super Sedan Looks Like

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Aston Martin has revealed the first official images of the production version of its new Lagonda ultra-luxury sedan, or super saloon as the British automaker calls it.

Though this particular model will be sold in extremely limited numbers by invitation only to clients in the Middle East, reviving the legendary Lagonda nameplate is the start of a larger initiative by Aston Martin. Design director Marek Reichman said at a press event in Scotland this summer that the company aims to grow its portfolio with other vehicles wearing the Lagonda name.

This is the first new Lagonda sedan in 25 years. It was inspired by one of the same name that debuted in 1976 and was made through 1990. Fewer than 650 were produced.

The wedge-shaped design on the original Lagonda was radical in its day. It also was reportedly the first car in the world to use computerized engine management and a digital instrument panel. But the car was plagued with problems, particularly as related to the newfangled digital technology.

Aston Martin has released very few details about the new Lagonda, except to say that it will be built using the same lightweight aluminum architecture as seen on the Vanquish and other current models. The companys 6.0-liter V12 is a likely choice for the engine, given that Riechman said the sedan will offer exceedingly high levels of performance.

The company has not said when the first deliveries will be made, nor how much the super sedan will cost. But given how pricey the previous Lagonda was, some speculate the new version will run at least $500,000.

You can see all the Lagonda photos that Aston Martin released here.

Credit: Aston Martin

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Here's What The 2015 Aston Martin Lagonda Super Sedan Looks Like

Nick Russell "Brown Eyed Girl" The Spirituality of Van Morrison @ Congregational Church of Patchogue – Video

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Nick Russell "Brown Eyed Girl" The Spirituality of Van Morrison @ Congregational Church of Patchogue
Nick #39;s voice brings fresh live to this classic! Learn about - The Congregational Church of Patchogue Outreach http://churchonmainstreet.org/?page_id=71 The Spirituality of Van Morrison Concert...

By: jAALTO!

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Nick Russell "Brown Eyed Girl" The Spirituality of Van Morrison @ Congregational Church of Patchogue - Video

Robert Bruey "Tupelo Honey" The Spirituality of Van Morrison @ Congregational Church of Patchogue – Video

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Robert Bruey "Tupelo Honey" The Spirituality of Van Morrison @ Congregational Church of Patchogue
Robert #39;s rich fulsome voice inhabits the song! Learn about - The Congregational Church of Patchogue Outreach http://churchonmainstreet.org/?page_id=71 The Spirituality of Van Morrison Concert...

By: jAALTO!

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Robert Bruey "Tupelo Honey" The Spirituality of Van Morrison @ Congregational Church of Patchogue - Video