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Category Archives: Psoriasis

Psoriasis or rheumatoid arthritis linked to heart risk

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Several conditions that stem from a malfunctioning immune system psoriasis, psoriatic arthritis and rheumatoid arthritis may create a higher than average risk for heart-related problems and death, a new study finds.

Its not terribly surprising that there is an increased risk of heart disease because of the similar levels of systemic inflammation, said co-lead author Dr. Alexis Ogdie of the rheumatology division in the Perelman School of Medicine at the University of Pennsylvania in Philadelphia.

Whole-body inflammation has also been linked to premature plaque buildup in the arteries, Ogdie told Reuters Health in an email.

The rough, red skin patches characteristic of psoriasis are caused by a chronic autoimmune disease affecting 7.5 million people in the U.S., according to the National Psoriasis Foundation, and can be treated with topical creams, ultraviolet light therapy or drugs.

Ten to 20 percent of people with psoriasis also develop a form of inflammatory arthritis associated with the disease, according to the Centers for Disease Control and Prevention.

Rheumatoid arthritis is a systemic inflammatory disease caused by the immune system as well. It affects more than 1 million U.S. adults, mostly women, according to the American College of Rheumatology.

Psoriasis and rheumatoid arthritis have previously been linked to heart disease but there have been limited studies in psoriatic arthritis, Ogdie said.

For the new study, Ogdie and her colleagues used primary care medical records in the UK to compare more than 138,000 adults with psoriasis, another 8,700 with both psoriasis and psoriatic arthritis and almost 42,000 people with rheumatoid arthritis to more than 81,000 other adults with none of the conditions.

The analysis followed all the subjects between 1994 and 2010.

More than half of those with rheumatoid arthritis or psoriatic arthritis had been prescribed a disease-modifying antirheumatic drug (DMARD) such as methotrexate, sulfasalazine or azathioprine, or a biologic DMARD like adalimumab.

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Psoriasis or rheumatoid arthritis linked to heart risk

What is Psoriasis and How to treat Psoriasis – Positive Homeopathy – Doctors Talk – Video

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What is Psoriasis and How to treat Psoriasis - Positive Homeopathy - Doctors Talk
Doctors Talk is an exclusive Program by CVR Health TV in which a Specialist Doctor will solutions to health problems and treatments to that particular health...

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What is Psoriasis and How to treat Psoriasis - Positive Homeopathy - Doctors Talk - Video

New online psoriasis resource launched

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Living with psoriasis can affect many aspects of your daily life including your overall physiological and emotional health1. To coincide with World Psoriasis Day (29 October) and help people understand and manage their condition more effectively, a new educational website, mypsoriais.co.nz has been launched by AbbVie.

In New Zealand there has been a real need for information specifically for Kiwis, as a survey- by AbbVie revealed many New Zealanders (57% of survey participants) have never accessed any type of online psoriasis support.2 mypsoriasis.co.nz specifically addresses this need by providing a range of support materials including a useful My Journey tab to help patients map their psoriasis journey and learn some of what they can expect as part of living with psoriasis in New Zealand.

Psoriasis is a relatively common autoimmune disease that affects one in 50 New Zealand adults. It is caused by over-activity of the immune system in the skin. It most frequently develops in young adults and continues throughout their life. The most common form of psoriasis causes raised, inflamed, scaly, red skin lesions, known as plaques.1

Dermatologist Dr Steven Lamb says World Psoriasis Day is a really important event in helping raise awareness of an often overlooked condition.

"World Psoriasis Day provides a good opportunity to educate the public about psoriasis and highlights what its like living with the condition. It also helps those living with psoriasis realise that there are effective treatments and that they don't have to put up with the symptoms and psychological effects that come with having psoriasis."

The online quantitative survey completed by 492 New Zealanders also found there was a lack of available information on the likely prognosis and implications of psoriasis at diagnosis, with nearly half of survey respondents (49%) indicating that they did not feel they were given sufficient information about the condition and what their diagnosis meant for them.2

Feedback such as this from patients and a lack of awareness in the community about psoriasis were the driving forces behind creating the educational website.

"We have a greater understanding now of the psychological and social effects of psoriasis on the individual patients who live with the condition having significant impaired quality of life. Patients have social isolation issues, difficulty maintaining relationships, avoidance of social situations and higher rates of stress and anxiety.

"There is also good evidence now that psoriasis is more than just a skin disease with up to 30% having arthritis symptoms and other comorbidities such as obesity, hypertension, high cholesterol, excessive alcohol intake and cardiovascular disease. Consequently psoriasis patients have a reduced life expectancy as well as a poorer quality of life," adds Dr Lamb.

Mike Jones, from Christchurch, developed psoriasis when he was in his early twenties. At the time he had a large social network, swam 4.5km a day and travelled extensively overseas.

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New online psoriasis resource launched

UCI scientists identify lesion-healing mechanism in psoriasis

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PUBLIC RELEASE DATE:

27-Oct-2014

Contact: Tom Vasich tmvasich@uci.edu 949-824-6455 University of California - Irvine @UCIrvine

A UC Irvine-led study has revealed the underlying genetic factors that help repair skin lesions caused by psoriasis, which could engender new methods of controlling the lingering condition.

Dr. Bogi Andersen, professor of biological chemistry and endocrinology at UCI, and colleagues discovered that a gene called grainyhead known to be important in epidermal development and wound healing triggers a repair pathway for psoriasis lesions. Conversely, they found that deletion of this gene increased the severity and longevity of the disfiguring patches.

"Our research suggests that targeting this mechanism of healing may lead to pharmaceutical products that limit the itchy, painful lesions all psoriasis sufferers must endure," Andersen said. Study results appear online Oct. 27 in The Journal of Clinical Investigation.

Psoriasis is a chronic skin condition caused by an overactive immune system in which immune cells secrete inflammatory mediators that cause thickening and other abnormalities in the epidermis, the outermost layer of the skin. These lesions look like scaly plaques, and they heal at a rate dependent upon the severity of the disease.

The researchers learned that in psoriasis a compound called grainyhead-like 3 which binds to DNA to control the rate of transcription of genetic information from DNA to messenger RNA orchestrates the activation of an epidermal repair pathway. (The grainyhead gene was initially discovered in fruit flies, where it's important for wound healing.)

They also found it easier to induce psoriasis-like lesions in mice lacking the GRHL3 gene. Furthermore, these lesions did not resolve properly and persisted even in the face of active immune suppression treatments currently being studied for the disease.

"Our study indicates that an evolutionarily ancient epidermal repair pathway is activated in psoriasis lesions and that this pathway suppresses disease severity and helps heal the lesions," Andersen said. "We speculate that abnormalities in this pathway might contribute to disease severity and that in the future this mechanism could be targeted to help treat psoriasis."

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UCI scientists identify lesion-healing mechanism in psoriasis

Psoriasis itchy skin healing – John Mellor Christian Prayer Ministry – Video

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Psoriasis itchy skin healing - John Mellor Christian Prayer Ministry
Psoriasis itchy skin healing - John Mellor Healing Ministry. http://www.johnmellor.org. John Mellor, an International Australian Healing Evangelist. John Mellor has a gift of healing and miracles...

By: John Mellor

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Psoriasis itchy skin healing - John Mellor Christian Prayer Ministry - Video


  1. Psoriasis