Psoriasis patients buoyed by new treatments

Andrew Gosses daily battle with psoriasis came to a breaking point when he awoke one morning eight years ago.

Keith Gosse/The Telegram

Andrew Gosses life changed dramatically with the development of new treatments for psoriasis, a disease he has suffered since age 17.

He awoke with his pyjamas and socks stuck to him due to the bleeding and oozing from the lesions that covered much of his body.

It had been another restless night of uncontrollable itching and pain, and the strength hed always mustered to clean himself up, apply ointments and prepare for the day ahead failed him.

At 34 years old, I woke up one morning and my wife knew there was something extra wrong. She has always known me with psoriasis. She was always there, very supportive, and I was slumped over on the bed, Gosse said.

She asked what was wrong. I turned around in tears and I said, Im sick of being alive. I was done.

Ive never really contemplated suicide, but there are so many people in this country who have committed suicide because of psoriasis.

According to the Living Well With Psoriasis website, psoriasis is a skin disorder in which skin cells multiply up to 10 times faster than normal. As cells reach the skins surface and die, their sheer volume causes raised, red patches called plaques to develop. These plaques are often covered with silvery-white scales.

Psoriasis affects about one million people in Canada. It is a chronic, autoimmune condition, which means the bodys immune system isnt responding as it should to healthy body tissue.

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Psoriasis patients buoyed by new treatments

High prevalence of psoriasis in province: expert

Newfoundland and Labrador likely has one of the highest prevalence of psoriasis in the world, says Dr. Wayne Gulliver, professor of medicine and dermatology at Memorial University.

Among the 11 dermatologists who practice here, weve seen about 10,000 patients, which is about two per cent of the population, Gulliver said.

Around the world they say the prevalence is two per cent, and Newfoundland and Labrador is probably four to five per cent because we probably havent seen every patient yet. Weve only seen half of them. And we see a lot of quite severe psoriasis and we see lots of patients with the associated illnesses linked to psoriasis like arthritis, diabetes, high blood pressure and high cholesterol.

Gulliver noted there have been a number of genes discovered linked to psoriasis, and a theory is that one of those genes produces a protein that is important in fighting tuberculosis (TB).

Our theory is that back in the 1920s we had a lot of TBhere, so the question is, did having psoriasis give you a survival advantage to fight tuberculosis? Gulliver said. We know that patients with psoriasis certainly are resistant to certain types of infection. One of my colleagues from Spain just wrote a paper he does quote this particular theory in that.

Gulliver notes that while they havent reached the point where 100 per cent of patients are having 100 per cent clear skin, the new treatments available are helping reach that goal.

Earlier this month, Health Canada approved a new biologic (injectable) treatment for psoriasis called Cosentyx which is making waves.

Theres a whole bunch of new drugs in the pipeline. Theres actually two other drugs in this class that are under study, Gulliver said. For the psoriasis patient, its not if we are going to get them better, its when we are going to get them better, and the majority of patients should be able to have excellent control of their condition. Did we think wed see it? We all hoped for it and the reality is certainly coming through for us.

gwhiffen@thetelegram.com

Organizations: Health Canada

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High prevalence of psoriasis in province: expert

Tampa dermatologist easing severe eczema and psoriasis cases with cutting edge treatment

Tampa dermatologist Dr. Seth Forman, one of a selected few physicians to offer innovative treatments, is relieving even the most severe conditions of eczema and psoriasis

To help alleviate these harsh diseases, Dr. Forman offers the most advanced treatments and conducts ongoing clinical trials to help find the most effective remedies.

While many will just chalk it as a simple skin disease, I take eczema and psoriasis very seriously, says the Tampa dermatologist. These conditions can be debilitating for those suffering from them, not just cosmetically, but physically.

Also called atopic dermatitis, eczema is an itchy red rash that can appear all over the body according to the National Eczema Association. Approximately 30 million people, mostly children, in the United States suffer from the condition.

Psoriasis is an autoimmune disease that causes raised, red, scaly patches to appear on the skin, per the National Psoriasis Foundation. The disease often develops between the ages of 15 and 35.

Eczema and psoriasis can be unbearable for people affected with the condition, but my office has been dedicated to easing the pain, physically and emotionally for our patients, continued Dr. Forman.

With access to the newest and most effective treatments, weve been able to help the most extreme cases reduce, or show absolutely no signs of, these unsightly ailments.

The Tampa dermatologist is currently enrolling patients in clinical trials for both skin diseases. For more on Dr. Seth Forman, Tampa dermatology or Forman Dermatology and Skin Cancer Institute, please visit http://www.FormanDerm.com.

About Dr. Seth Forman:Dr. Forman is a board-certified dermatologist practicing in Tampa, Florida. He was voted the Best Dermatologist in Carrollwood in 2011 and 2012 by the Carrollwood News and Tribune. In December 2011, he opened his new Tampa dermatologyoffice, Forman Dermatology and Skin Cancer Institute, where he gives psoriasis sufferers access to the latest treatment options, including topical and oral medications, as well as biological and phototherapy. Dr. Forman is one of the few Tampa dermatologists to offer narrowband light therapy, which uses pharmaceutical grade light to suppress psoriasis. Hes also one of the few board-certified dermatologists in the U.S. to use the SRT-100 radiotherapy to treat basal cell carcinoma, the most common form of skin cancer.

MEDIA CONTACT Nathan Legg PR Firm: The Publicity Agency Email:Nathan@SeligMultimedia.com Phone: (813) 708-1220 x 7781 Website:www.thepublicityagency.com

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Tampa dermatologist easing severe eczema and psoriasis cases with cutting edge treatment

National Psoriasis Foundation backs bill to lower treatment cost

PORTLAND, Ore., March 26, 2015 /PRNewswire-USNewswire/ -- Americans with chronic diseases like psoriasis and psoriatic arthritis may be better able to afford vital medication to effectively manage their conditions, thanks to bipartisan legislationthe Patients' Access to Treatments Act (PATA)introduced in Congress yesterday.

The legislation, introduced in the U.S. House of Representatives by Reps. David McKinley (R-WV) and Lois Capps (D-CA), aims to lower out-of-pocket costs for systemic and biologic drugs, which are used to treat chronic and disabling diseases like psoriatic disease, rheumatoid arthritis and lupus, and cancers like leukemia and lymphoma. These drugs are often placed on "specialty tiers," where a portion of the total cost of the drug is passed on to patients, called a coinsurance.

Learn more about PATA and its impact on people with psoriatic disease: http://www.psoriasis.org/pata-info.

Specialty drugs for psoriasis and psoriatic arthritis cost millions of Americans upwards of $1,500 to $5,000 per month in out-of-pocket costs. According to a 2015 study examining the economic burden of psoriasis, total direct costs of the diseasesuch as medical expenses from doctor's appointments and treatments--can cost upwards of $8,000 per person annually.

PATA will improve treatment adherence and health outcomes for chronic diseases by making medically necessary medication more accessible. In a recent National Psoriasis Foundation survey, more than 22 percent of respondents said cost was a barrier to accessing the treatments they need to manage their disease and avoid health complications.

"Psoriasis is a painful, chronic, noncontagious autoimmune disease without a cure, costing our society up to $135 billion annually. Up to 30 percent of people with psoriasis develop psoriatic arthritis," said Randy Beranek, National Psoriasis Foundation president and CEO. "Access to safe and effective treatments is the number one challenge for our community. PATA will lower out-of-pocket costs on needed medications so millions with psoriatic disease can better manage their condition."

As part of the Coalition for Accessible Treatments a partnership of 32 patient and provider organizations that created the PATA legislation the National Psoriasis Foundation fights for fair and affordable access to treatments for millions of Americans with psoriasis and psoriatic arthritis. These are serious, systemic autoimmune diseases with a profound physical, social, psychological and financial burden.

Psoriasis, the most common autoimmune disease in the country, increases people's risk for heart disease, heart attack, stroke and early death. Treatment with systemic and biologic drugs can reduce a person's risk for these comorbidities. Additionally, treating psoriatic arthritis early and effectively can prevent irreversible joint damage.

To learn more about the Patient's Access to Treatments Act and urge your member of Congress to support this legislation, visit http://www.psoriasis.org/pata-info.

About the National Psoriasis FoundationNational Psoriasis Foundation (NPF) is the world's largest nonprofit serving those with psoriasis and psoriatic arthritis. Our priority is to provide the services people need to take control of their condition, while increasing research to find a cure. In addition to serving more than 2.1 million people annually through our education and advocacy initiatives, NPF has funded more than $11 million in psoriatic disease research grants and fellowships. Learn more at http://www.psoriasis.org or call 800.723.9166. Follow us on Facebook and Twitter.

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Boehringer reports positive results from Phase II psoriasis trial

PBR Staff Writer Published 23 March 2015

Boehringer Ingelheim has reported positive results from a Phase II trial that evaluated the efficacy and safety of the new investigational compound BI 655066 versus ustekinumab in patients with moderate-to-severe plaque psoriasis.

The trial showed that nearly double the percentage of patients achieved clear or almost clear skin after 12 weeks of treatment with BI 655066 compared to ustekinumab.

The company said that BI 655066 had similar safety and tolerability compared to ustekinumab.

Primary Phase II analysis from the trial showed that the selective IL-23 inhibitor BI 655066 was superior to ustekinumab, an IL-12/23 inhibitor.

The efficacy analyses were based on pooled dose results for BI 655066 of 90and 180mg.

Probity Medical Research president Alexander Papp said: "The results of this study are compelling. Patients showed significant skin improvement with BI 655066 compared to ustekinumab, a widely acknowledged and accepted standard of treatment for moderate-to-severe psoriasis.

"These results are particularly encouraging given the study focused on a new treatment goal of PASI 90. The results showed that more patients treated with BI 655066 reached this rigorous primary endpoint.

"Furthermore, we saw that patients continued to achieve clear or almost clear skin beyond week 12. Achieving clear or almost clear skin can make a real difference to patients as they have to deal with the daily impact of psoriasis."

During the trial, a total of 166 patients were randomly assigned to one of three dose groups of BI 655066 18mg, 90mg or 180mg, or ustekinumab.

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Boehringer reports positive results from Phase II psoriasis trial

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