Neurology | Neurology conferences | Neuro congress …

Posted on February 29, 2020 by Danzig

Advanced Neurology 2020

We are extremely gratified to declare our upcoming fortuitous neurology conference 4th World Congress on Neurology and TherapeuticsConference is scheduled during May 08-09, 2020 at Prague, Czech Republic.

It is our boundless privilege to solicit each one of you to our meritorious neuro meet of all the dignitaries worldwide over there. We believe in serving people with the most advanced solutions to Neurological Impairments where we stood prior in our last event 3rd World Congress on Neurology and Therapeutics Conference in Madrid, Spain. It was a tremendous success over the year to establish a strong affinity with our advanced neurological solutions, diagnosis and NeurotherapeuticsConference.

View our Past Conference Report of Advanced Neurology 2019 at https://neurology.pulsusconference.com/2019

Our propitious neurology congress is tailored around the theme Know the Unknown Advanced Solutions on Neurology

Weve constructed this years neurology conference primarily based on input from you, so get equipped for a streamlined agenda packed with neurologists, neurosurgeons, neuro specialists, neuro freaks, neuro physicians, industry insights, innovations, and masses of opportunities to share ideas and provide remarks.

Would like to give a glimpse of whats in:

Drop a line or note! it is all really worth to know from us.. neuromeet@pulsusgathering.com

Sincerely

Executive Director

Session on Neurology

The observe of neurons that is the functional unit of mind worries with the brains normal functioning, neural disorders, neural diagnosis and neurology treatment which incorporates each aspect about the condition of the ailment in our neurology conference. This place of interest offers with the backbone, the fearful gadget such as its masking, blood vessels, afferent and efferent tissues is thought to be neurology. A physician who specializes in neurology is known as a neurologist. The top neurologists treats troubles which have an effect at the brain, spinal cord, and nerves, which incorporates Cerebrovascular treatment, Spinal disorders and neurological disordersin various sessions of neurology conference.

Related Society & Associations Socit Franaise de Neurologie ; Croatian Neurological Society ; Finnish Neurological Association ; Cyprus Neurological Society ; Estonian Society of Neurologists & Neurosurgeons ; Czech Society of Neurology ; Danish Neurological Society ; Bulgarian Society of Neurology ; Albanian Society of Neurology ; Belgian Neurological Society ; Association of Azerbaijan Neurologists and Medical Geneticists ; Armenian Association of Neurologists

Session on Neurogenesis

The process of formation of the neuron cells from the predefined cells to the grownup neurogenesis is described as Neurogenesis. This mechanism takes area throughout embryogenesis by using the neural stem cells and progenitor cellsin our neurology conference. This mainly deals with the form and features of diverse varieties of science in neurology. via a chain of genetic mechanisms of mobile fate dedication, many unique types of excitatory and inhibitory neurons are made from exceptional kinds of neural stem cellsin every session of neurology conference. The boom method in area and evolution of practical matter. Our neurology conference moreover describes about the biophysical parameters of highbrow capability and new techniques for the development of neural cells in distinctive way of life medium.

Related Society & Associations Hellenic Association of Neurology ; Latvian Neurologists Association ; Hungarian Society of Neurology and Psychiatry ; Icelandic Neurological Society ; Societ Italiana di Neurologia ; Irish Institute of Clinical Neuroscience ; Norwegian Neurological Association ; Association of British Neurologists ; Turkish Neurological Society ; Polish Neurological Society ; Socit Suisse de Neurologie (Schweizerische Neurologische Gesellschaft) ; Portuguese Society of Neurology (Sociedade Portuguesa de Neurologia) ; Romanian Neurological Society ; All-Russian Society of Neurologists ; Yugoslav Neurological Society ; Slovenian Society of Neurology ; Sociedad Espaola de Neurologia ; Swedish Neurological Society (Svenska Neurologforeningen)

Session on Neurophysiology

The take a look at of nature and foundation of the brain which additionally issues with the functioning of the nervous system, frequently the use of the neurophysiological or molecular organic system that is the subspecialty of both the frame shape and Neuroscience as awesome regions of brain represent indicators to distinct elements of the body in neurology conference. This concern is counted need to deliver an extraordinary description of the revolutionized anatomy of the nervous system, the motor reaction manipulates neurons, perception processing, and reminiscence neurons. Neurology conferences discussions also can be made in neuromuscular physiology, neural mechanisms of higher nerve interest and troubles of Neuroscience also may be conferred in every session of neurology conference.

Related Society & Associations International Federation of Clinical Neurophysiology: IFCN ; American Clinical Neurophysiology Society ; The British Society for Clinical Neurophysiology ; Canadian Society of Clinical Neurophysiologists ; American Clinical Neurophysiology Society ; German Society for Clinical Neurophysiology and Functional Imaging (DGKN) ; The Italian Clinical Neurophysiology Society ; International Society of Intraoperative Neurophysiology (ISIN) ; Malaysian Society of Neuroscience (MSN) ; Clinical Neurophysiology Society of South Africa

Session on Clinical Neurology

Our series of neurology conferences deals with the sicknesses of the central nervous system consist of some of the most disabling situations, such as multiple sclerosis (MS), stroke, motor neuron disorder (MND), Alzheimers, Huntingtons and Parkinsons sickness like various other sub category in neurology conference. Those neurological disorders have been the threat to all the people who really strive to eradicate it and establish a healthy aging process and healthy environment for their circle of relatives and carers, and to society as an entire from this neurology conferences. We need to understand underlying neurological treatment with a purpose to treat these situations successfully. Neurology congress provides an appropriate setting to percentage facilities, know-how and as well as realise our purpose of making use of our studying in medical exercise

Related Society & Associations Association of University Professors of Neurology ; Child Neurology Society ; Congress of Neurological Surgeons ; American Association of Neurological Surgeons ; American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) ; American Association of Neuropathologists ; American Association of Neuroscience Nurses ; American Brain Foundation ; American Epilepsy Society ; American Society for Experimental Neuro Therapeutics (ASENT) ; American Society for Neural Transplantation & Repair ; American Society for Neurochemistry ; American Society of Neuroimaging ; American Society of Neuroradiology ; American Society of Neurorehabilitation

Session on Neurological Nursing

Neuroscience nurses a very challenging nursing science contend with humans with diffusion of neurological conditions and issues throughout the lifespan and dealing with all health care settings amidst neurology conferences. The purpose of neurology events is to realize the nursing opportunities which have the ability to maximize consequences to prevent, to take care of the people with excessive neurological disorders. there are numerous neuro conferences specialities of encompassed internal this subject of practice collectively with (however now not constrained to) the subsequent: geriatric nursing, neurosurgery, neurotrauma, Neuroscience critical care, prolonged-time period neurological disorders, Parkinsons sickness, epilepsy, existence-limiting neurological disorders in our world neuro congress, e.g. motor neurone disorder, Huntingdons ailment especially in neurology pulsus conference.

Related Society & Associations American Association of Neuroscience Nurses ; Association of Child Neurology Nurses ; British Association of Neuroscience Nurses (BANN) ; Canadian Association of Neuroscience Nurses ; Epilepsy Nurses Association ; East Coast Community Healthcare's Neurological Nursing Service ; Movement Disorder Society ; Association of University Professors of Neurology ; Child Neurology Society ; Congress of Neurological Surgeons ; International Brain Injury Association ; International Neuromodulation Society ; International Parkinson and Movement Disorder Society

Session on Neuropediatric

Neuropediatric is the branch of medication handling mental health, neurological disorders of children. The concern of Paediatric Neurology, additionally called Paediatric Neurology, encompasses issues of the brain, spinal twine, peripheral nerve and muscle affecting babies, youngsters and younger human beings in our neurology conference. The form of patients seen through paediatric neurologists varies from people with common, pretty sincere conditions, inclusive of cerebral palsy or migraine. This robust world neurology congress type of situation lets in Paediatric Neurologists to shape their medical or clinical careers in line with their scientific or studies pursuits from our neurology conferences. Paediatric neurogenetic issues are sicknesses of the mind, spinal cord, nerves and muscle tissues which can be resulting from modifications in genes or chromosomes. There are loads of neurogenetic disorders that could be discovered in every one among kind methods in every aspects of neurology conference.

Related Society & Associations European Paediatric Neurology Society (EPNS) ; Child Neurology Society ; British Paediatric Neurology Association ; The Canadian Association Of Child Neurology ; Belgian Society of Pediatric Neurology ; American Society of Pediatric Neuroradiology ; International Society of Neuroimmunology ; Japanese Society for Neuroimmunology ; Italian Association of NeuroImmunology ; Indian Immunology Society ; International Society of Neuroimmunology ; Pediatric Society of Neuro-oncology ; German Neuropediatric Society ; Nordic Neuropediatric Society ; Scandinavian Neuropediatric Society

Session on Neuroimmunology

Neuroimmunology is an area of neuroscience, combining the immune system and the nervous systemin neurology conferences. The immune system administers defence in competition to those organisms, inefficiency of the equal consequences in Infections. Neuro Infections have been set up to sell outstanding affected individual care and research for immune and infectious issues of the apprehensive device through training of clinical and simple generation researchers, growing and offering diagnostic services, consultation services and supporting develop new modes of remedy from our keynotic presentations of neurology conference. Collectively our neurology conference offer understanding in several major immune and infectious disorders of the anxious system, consisting of Neuro-AIDS and other viral and opportunistic infections, poisonous Leuko-encephalopathies, Transverse myelitis and other myelopathies, GuillainBarr syndrome, persistent demyelinating polyneuropathy, Myasthenia gravis and different immune-mediated problems of the peripheral nervous systemeven more recent conditions from neurology conference.

Related Society & Associations Austrian Society of Neurology (sterreichische Gesellschaft fr Neurologie) ; Georgian Society of Neurologists ; Socit Luxembourgeoise de Neurologie asbl ; Deutschen Gesellschaft fr Neurologie ; Lithuanian Neurological Society ; British Society For Clinical Neurophysiology ; The Physiological Society ; Neurological Sciences and Neurophysiology ; The International Neuropsychological Society ; British Peripheral Nerve Society ; International Society for Autism Research ; National Neurotrauma Society ; North American Spine Society ; Peripheral Nerve Society ; United Council for Neurologic Subspecialties

Session on Neuroplasticity

Neuroplasticity is also known as brain plasticity and neural plasticity that encompasses the 2 synaptic and non-synaptic plasticity and it refers to improve in neural pathways and synapses due to difference in behaviour, surroundings, neural strategies, wondering, and feelings similarly to changes due to physical are discussed in neurology conference. The goal of our neurology congress is to understand the brain plasticity advances in neurite transforming and the way to increase neural connections. Neurorehabilitation is a medical approach which goals to beneficial aid recovery from nervous system damage and to lessen or make amends for any practical alterations because of it.

Session on Neural Circuits ; Neural feedback

Neurofeedback (NFB), also called Neurotherapy, neurofeedback or EEG biofeedback is a form of biofeedback that makes use of actual-time shows of electroencephalography to demonstrate brain activity, frequently with an intention of controlling significant nervous system activity in our neurology conference. Through monitoring brain activity, its possible to teach our brain to provide specific cognitive function that can aid relaxation, help us be more inexperienced in our each day obligations, or offer non-pharmaceutical treatment for plenty conditions and issues is the vital role of neurology conference. Our neurologists, neuro conference participants are also neurofeedback practitioners and researchers who are pushed to promote excellence in scientific exercise, educational applications, and research in applied neuroscience to be able to better apprehend and enhance brain mechanism. Biofeedback therapy: uses and benefits: types, motive and dangers, Biofeedback device/devices, development of Biofeedback remedy, situations dealt with the usage of Biofeedback.

Related Society and Associations International Society for Neurofeedback & Research ; The Association for Applied Psychophysiology and Biofeedback (AAPB); Western Association of Biofeedback and Neuroscience ; Society of Applied Neuroscience ; Applied Neuroscience society of Australasia (ANSA); Neurofeedback Society of UTSA ; Northeast Region Biofeedback Society (NRBS) ; Cognitive Neuroscience Society ; Mid-Atlantic Biofeedback Society ; International Society for Neuronal Regulation ; Mexican Society for Biofeedback and Neurofeedback (SMBN) ; Brandywine Valley Counselling and Neurofeedback Center ; The Biofeedback Society of Florida ; Autism Society Inland Empire ; Spanish Society of Bio and Neurofeedback (Sebine) ; Center for Academic and Psychological Services ; Autism Society Philippines ; Alpha Brain-Wave Neurofeedback Training ; Body Mind and Brain Neurotherapy Gold Coast

Session on Neurostimulation

The sector of Neurostimulation is present process notable increase, neuro activity stimulation strategies are suddenly reworking studies into brain mechanisms, from the molecular to the behavioral, and provide new strategies to therapeutics for neuro disorders. in lots of processes, the sector of brain stimulation represents a paradigm shift, augmenting and on occasion replacing the prominent psychopharmacological techniques of the beyond several a long time. Cognitive neuroscientists will mingle with neurosurgeons and brain modelling physicists. Neurology conference pass-disciplinary meeting will also offer the opportunity to have interaction with founders and luminaries within the neurology area.

Related Society and Associations International Neuromodulation Society (INS) ; International Society for ECT and Neurostimulation (ISEN) ; Brazilian Medical Association ; Association of Pallidal Neurostimulation ; American Association for the Advancement of Science ; Neurological Societies Task Force on neurostimulation for pain ; Neuromodulation - Interstitial Cystitis Association ; Anxiety and Depression Association of America (ADAA)

Session on Neurotherapeutics ; Neuropharmacology

It's miles an older time period for the remedy of neurological disorders which have an impact on the brain mechanism and the nervous system which can be treated with certain therapeutic modalities and novel research that is ongoing in research activity. Neurotherapeutics session almost covers half of the world's advanced solutions for the neurological impairments, neurological disorders and what not to be added. There can be a profound boon within the gathering of our world neuro congress where diagnostics technique and drug discovery inside the area of Neurology and various allied sciences under neurology can be discussed. It consists of Stem cells and remedy, Nerve damage and restore clinical Case document, Neurogenesis, cell and gene-primarily based method and Neurotransmitter release and cell restore.

Related Neurotherapeutics Conference | Advanced Neurology Conference | Neurotherapeutic Symposium | Experimental Neurotherapeutics Conference | Neurology Conferences 2020

Related Society and Associations American Society for Pharmacology and Experimental Therapeutics (ASPET) ; Society on NeuroImmune Pharmacology ; Canadian Society of Pharmacology and Therapeutics (CSPT) ; Indian Pharmacological Society ; Japanese Society of Neuropsychopharmacology ; Australasian Society of Clinical and Experimental Pharmacologists ; International Union of Basic and Clinical Pharmacology (IUPHAR) ; International Behavioral Neuroscience Society ; American Society of Clinical Psychopharmacology (ASCP) ; Argentinean Society of Experimental Pharmacology ; American Society for Experimental Neurotherapeutics (ASENT)

Session on Neurological disorders ; Neurodegenerative disorders

Neurodegenerative disorders cause your mind and nerves to deteriorate through the years. They may be able to alternate your personality and reason confusion. They also can ruin your minds tissue and nerves. A few neuro disorders, such as Alzheimers disease, Parkinson's, Huntington's might, Dementia... also increase as you age. They may slowly impair your memory and idea strategies. Other neurological diseases, which incorporates Tay-Sachs ailment, are genetic and start at an early age. A neurological disorder is any turmoil inside the nervous system fundamental, biochemical or electrical irregularities inside the thoughts, spinal line or different nerves can bring about the neurology scope of manifestations. Neurology conferences relates all the cases of neurological manifestations incorporate lack of motion, muscle shortcoming, awful coordination, and lack of sensation, seizures, perplexity, torment and adjusted levels of awareness.

Related Society and AssociationsInternational Society for Neurofeedback & Research;The Association for Applied Psychophysiology and Biofeedback(AAPB);Western Association of Biofeedback and Neuroscience;Society of Applied Neuroscience;Applied Neuroscience society of Australasia(ANSA);Neurofeedback Society of UTSA;Northeast Region Biofeedback Society(NRBS) ;Cognitive Neuroscience Society;Mid-Atlantic Biofeedback Society;International Society for Neuronal Regulation;Mexican Society for Biofeedback and Neurofeedback(SMBN) ;Brandywine Valley Counselling and Neurofeedback Center;The Biofeedback Society of Florida;Autism Society Inland Empire;Spanish Society of Bio and Neurofeedback(Sebine) ;Center for Academic and Psychological Services;Autism Society Philippines;Alpha Brain-Wave Neurofeedback Training;Body Mind and Brain Neurotherapy Gold Coast

Session on Neuromuscular Disorders

Neuromuscular disorders are the illnesses which impair the functioning of muscle groups each right now via affecting the voluntary muscle groups or with the resource of affecting the nerves system or neuromuscular junctions. revolutionary muscle weak factor is the condition in those neurological disorders. Neuromuscular disorders may be labelled as ailments of the Neuromuscular disorders, neuron cellular problems, Motor neuron disorder and so on. so as to diagnose these sicknesses, Electromyography should be used, inside the route of Electromyography, small electric impulses are given to the nerves and electric responses are recorded. This allows discovering the lack of nerve fibres and problems of insulation of nerves. Neuromuscular conference allows to interpret in these criterias all along the neurology conference in Prague.

Related Neuromuscular Disorder Conferences | Annual Neurology Congress | Neuromuscular Conferences | Neurology Conferences | Neurology 2020 Europe Conferences

Session on Neurosurgery

Medical and Surgical examination which offers with the treatment of neurological problems, neural disorders, blood clots, and many other specific neurology issues related to the brain, spinal cord, peripheral nerves, central nervous and in addition operating the cranial cerebrovascular system is coined to Neurosurgery. Emergencies like intracranial haemorrhage and neurotrauma are essentially involved in most of the neurosurgery. some of the scientific sessions of neurosurgery conference includes vascular neurosurgery and endovascular neurosurgery, stereotactic neurosurgery, beneficial neurosurgery, and epilepsy surgery, mind tumor, oncological neurosurgery, skull base surgical treatment, spinal neurosurgery, peripheral nerve surgical operation. Neurosurgery is a whole-time dedication to treating patients with neurological disorders and to the search for better therapies, cures and investigates the most promising advances in neuroscience research, and train tomorrow's leaders in neurosurgery.

Session on Neuroimaging ; Radiology

Neuroradiology performs a vital position inside the prognosis and characterization of various Neurological disorders. Neurology conferences entails amazing sorts of Imaging studies collectively with Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). simple Radiography and Ultrasound are used in a confined foundation especially in Pediatric population. Neuroimaging is the mapping of the human mind the usage of purposeful Magnetic Resonance Imaging (fMRI). Neuroimaging determines the association among brain mechanism elements and health influence on mind growing older at some level within the person lifespan. Neuroimaging determines how difference and trade-in Cerebral structure, complexly relates to behaviour and Cognition at a couple of levels of analysis. Neurology Conference brings collectively various topics of interests consisting of practical Neuroimaging, Cognitive Neuroscience, and Cognitive mechanism models.

Session on Psychology ; Psychiatry

Exploration of neurology or all of those questions has been and is being undertaken in such disciplines as cognitive psychology, neuro linguistics, philosophy, artificial intelligence, robotics, neuroscience, training, cognitive sciences, behavioural economics, and others. The fundamentals and the minor in Cognitive science, neurology conferences consequently, constitute a proper means of bringing collectively students and neuro physicians in exclusive disciplines who percentage common interests. From our neurology conference, we are seeking to enhance the view supplied by way of every person discipline through exploration or the methodologies of Neurology. Interdisciplinary group of psychiatrists, clinical psychologists, forensic psychologists, neuropsychologists, occupational psychologists and health psychologists based within the Institute of Mental Health and enjoying close links with topics related to the neurosciences and the behavioural sciences.

Session on Behavioural Sciences

The study of the relationship between behavior, emotion, and cognition on the one hand, and brain feature on the other. Neuropsychology research the shape and characteristic of the mind as they relate to unique mental strategies and behaviours. medical neuropsychology is a uniqueness in professional psychology that applies standards of evaluation and intervention primarily based upon the medical look at human behavior because it pertains to normal and unusual functioning of the relevant nervous system. The robust factor of neurology congress is dedicated to improving the of brainbehaviour relationships and the software program of such understanding to human troubles.

Session on Clinical trials, case studies and recent researches

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With utmost appreciation, Advanced Neurology 2019 thanks all the participants for their sincere efforts to place our 3rd World Congress on Neurology and Therapeutics, October 07-08, 2019 in Madrid, Spain a successful and memorable one.

In a row of series, Pulsus Group has completed over three international Neurology conferences. We would really like to thank all of our outstanding dignitaries of world neuro congress for presenting us with the splendid keynotes, speakers, convention attendees, students, institutions, media partners and guests for making Advanced Neurology 2019 a success and top-notch event.

Pulsus Group hosted the 3rd World Congress on Neurology and Therapeutics during October 07-08, 2019 in Madrid, Spain at Rafaelhoteles Forum Alcal with the theme Neurology! Heal the world of Neurological Impairments... Benevolent response and active participation was received from the Editorial Board Members of supporting International Journals as well as from the leading academic scientists, researchers, research scholars, students and leaders from the fields of Neurology, Neuroscience and neurotherapeutics who made this event successful.

The neurology conference turned into marked with the aid of the attendance of young and brilliant researchers, enterprise delegates and talented pupil communities representing greater nations, who've driven this event into the path of achievement. This neurology conference highlighted through diverse periods on Neurological issues studies.

Advanced Neurology 2019 witnessed an amalgamation of unparalleled speakers who enlightened the gathering with their knowledge and discussed on various new-fangled topics related to the fields of Neurological Disorders, Neurotherapeutics, Neuro-imaging, Neurology, Neuroscience.

The neurology congress proceedings were performed through various scientific sessions and plenary lectures. Neurology conference changed into embarked with an opening ceremony accompanied by way of a sequence of lectures introduced by way of both Honourable guests and contributors to the Keynote discussion board.

Jacques Fantini | Aix-Marseille University | France

Nouara Yahi | Aix-Marseille University | France

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Neurology | Neurology conferences | Neuro congress ...

Neurologist weighs in on teen driving dangers as bill aims to change driving age in Ohio – WKYC.com

Posted on February 5, 2020 by Danzig

POWELL, Ohio Legislators in Ohio are currently considering a bill that would change the driving age for teens in Ohio. Ohio State Wexner Medical Center neurology experts provide new information to help form a better decision.

The bill would require teenage drivers under 18 years old to use their learner's permits for a full year before they can get a driver's license. If passed, minors would have to be at least 16 1/2 before they could get their probationary driver's license. The proposed legislation aims to give young drivers more experience behind the wheel prior to obtaining their license. The bill would extend the permit phase for minors from six months to 12 months.

RELATED: Proposed Ohio law would raise driving age

"I think 16 is the perfect age," said 16-year-old Anna Bean. "It allows us to get to the places we need to go for school, sports or a job."

But Anna Bean's mom is not so eager to hand over the keys.

"They are still learning and have not seen the aftermath of what happens," said mother Amy Bean.

Helping more people decide to buckle up and participate in safer driving practices are Amy Bean's life purpose. She was pushed to action within the community after a tragedy.

"16 years ago my husband died due to a drunk driving crash," said Bean.

Now, Bean works to make the roads safer through work with the group "Safe Delaware." She volunteers within the organization SAFE Delaware County.

SAFE stands for 'Safety Awareness for Everyone' and the coalition's purpose is to provide injury prevention awareness programs related to traffic safety and child safety. Bean said other parents who think the proposed delay for licenses is too much haven't seen the latest stats.

While parents and teens may debate the best age to drive, Ohio State Wexner Medical Center neurologist Dr. Kiran Rajneesh explains what science says.

"I think deciding the right age is a question for society, but one of the things as a neurologist that I focus on is how some of these experiences of driving impact brain development," said Dr. Rajneesh. "By the age of 16, the brain is structurally formed. But it is not matured yet. Complex planning, having the responsibility and having the ability to drive and be exposed to new experiences is crucial for brain development. So bumping the age back may hinder that exposure and experiences that are crucial in having these young adults develop into the well-adjusted adults we want them to develop into."

Rajneesh explained the human brain is structurally formed at 16 years old, however, the brain does not complete development and maturity until the mid-20s for most people. Because waiting until 25-years of age to drive seems unlikely, so Dr. Rajneesh says at the age of 16, most teens have responsible adults in the car guiding them to help develop those life lessons.

To learn more, just visit this website.

RELATED: Teen caught driving 105 mph blames too many hot wings, police say

RELATED: Driving Skills Pad helps teens 'take control' in Medina County

Continued here:
Neurologist weighs in on teen driving dangers as bill aims to change driving age in Ohio - WKYC.com

People with Neurological Disorders Have a Higher Risk of Committing Suicide – DocWire News

Posted on February 16, 2020 by Danzig

Having a diagnosis of a neurological disorder is associated with an increased risk of suicide, according to a recent study published in JAMA.

In this nationwide cohort study, researchers assessed 7,300,395 people 15 years and older living in Denmark from 1980 until 2016. They analyzed medical contact for head injury, stroke, epilepsy, polyneuropathy, diseases of myoneural junction, Parkinson disease, multiple sclerosis, central nervous system infections, meningitis, encephalitis, amyotrophic lateral sclerosis, Huntington disease, dementia, intellectual disability, and other brain diseases from 1977 through 2016.

The studys primary endpoint was defined as death by decide, and the researchers estimated this outcome using Poisson regressions, adjusted for sociodemographics, comorbidity, psychiatric diagnoses, and self-harm.

According to the results of the study, than 7.3 million individuals observed over 161.935,233 person-years, 35,483 died by suicide (median duration of follow-up, 23.6 years; interquartile range, 10.0-37.0 years; mean age, 51.9 years; SD, 17.9 years). Of those, the results showed that 14.7% were diagnosed with a neurological disorder, equivalent to a suicide rate of 44.0 per 100.000 person-years compared with 20.1 per 100,000 person-years among individuals not diagnosed with a neurological disorder.

The researchers observed that people diagnosed with a neurological disorder had an adjusted IRR of 1.8 (95% CI, 1.7 to 1.8) compared with those not diagnosed. The excess adjusted IRRs were 4.9 (95% CI, 3.5 to 6.9) for amyotrophic lateral sclerosis, 4.9 (95% CI, 3.1 to 7.7) for Huntington disease, 2.2 (95% CI, 1.9 to 2.6) for multiple sclerosis, 1.7 (95% CI, 1.6 to 1.7) for head injury, 1.3 (95% CI, 1.2 to 1.3) for stroke, and 1.7 (95% CI, 1.6 to 1.8) for epilepsy.

Moreover, the association varied according to time since diagnosis with an adjusted IRR for 1 to 3 months of 3.1 (95% CI, 2.7 to 3.6) and for 10 or more years, 1.5 (95% CI, 1.4 to 1.6, P<.001). Compared with those who were not diagnosed with a neurological disorder, those with dementia had a lower overall adjusted IRR of 0.8 (95% CI, 0.7 to 0.9), which was elevated during the first month after diagnosis to 3.0 (95% CI, 1.9 to 4.6; P<.001). The absolute risk of suicide for people with Huntington disease was 1.6% (95% CI, 1.0% to 2.5%).

The researchers wrote in conclusion that: In Denmark from 1980 through 2016, there was a significantly higher rate of suicide among those with a diagnosed neurological disorder than persons not diagnosed with a neurological disorder. However, the absolute risk difference was small.

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People with Neurological Disorders Have a Higher Risk of Committing Suicide - DocWire News

Repetitive Head Impacts: A One-Two Punch for Pro Fighters? – Medscape

Posted on January 2, 2020 by Danzig

Although both active and retired professional boxing and mixed martial arts (MMA) fighters experience brain volume loss after repetitive head impacts (RHIs), different brain regions are affected, a new study shows.

The distinction suggests that different pathways are at work in traumatic brain injury, the researchers conclude.

"The different regions that showed decline between active and retired fighters was one of the most important findings," lead author Charles Bernick, MD, MPH, of the Cleveland ClinicLou Ruvo Center for Brain Health in Las Vegas, Nevada, told Medscape Medical News.

"We speculate that the changes we saw in volumes of deep brain structures like the thalamus and corpus callosum in active fighters may represent the delayed effects of repeated axonal injury, whereas in the retired fighters, the volume changes in the hippocampus and amygdala may represent a neurodegenerative process," Bernick added.

The study was published online December 23, 2019, in Neurology.

Monitoring changes in regional brain volumes on MRI can be useful for following structural brain changes over time, prior research suggests.

The current study builds on previous investigations that linked RHIs to volume changes in specific brain regions. Those earlier studies, however, were cross-sectional, the authors note, and "less is known about using volumetric MRI techniques in a longitudinal manner in those exposed to RHI."

To learn more about the long-term effects of RHIs, the investigators assessed participants in the Professional Fighters Brain Health Study (PFBHS). The ongoing PFBHS started in 2011. Annual assessments include high-resolution T1-weighted anatomic MRI of boxers, MMA athletes, and age- and education-matched control persons. Participants also undergo computer-based cognitive testing, and they report RHI exposure history at each evaluation.

The study population of 204 participants included 50 active boxers, 100 active MMA fighters, 23 retired boxers, and 31 control persons. There were not enough retired MMA fighters to create that cohort.

The mean age of the active boxers was 29 years, and the mean number of fights was five. For active MMA athletes, the mean age was 29, and the mean number of fights was eight. For retired boxers, the mean age was 45 years, and the mean number of fights was 38. For the control group, the mean age was 31; none of the control persons had a history of head trauma.

Compared with control persons, active boxers experienced an average annual volume decrease of the left thalamus of 102.3 mm3/yr, a significant difference (P = .0004). They also displayed decreases in the mid anterior corpus callosum of 10.2 mm3/yr (P = .018) and in the central corpus callosum of 16.5 mm3/yr (P < .0001).

The active MMA fighters also experienced decreases over time, although these were less pronounced. The left thalamus decreased by 57.5 mm3/yr (P = .036), and the central corpus callosum decreased by 9.7 mm3/yr (P = .007).

The retired boxers experienced the most significant decreases in volume compared to control persons, but in different areas. For them, the left amygdala decreased by 32.1 mm3/year (P = .002); the right amygdala, by 30.6 mm3/yr (P = .008); and the right hippocampus, by 33.5 mm3/yr (P = .01).

Bernick and colleagues also assessed serum neurofilament light (NfL) levels. Higher NfL levels were found to be associated with significantly greater decreases in volumes of the left hippocampus, at 33.2 mm3/yr (P < .001), and of the mid anterior corpus callosum, at 7.68 mm3/yr (P = .015).

Among fighters with higher NfL levels, there was also a trend toward lower volumes of the left amygdala, the right thalamus, and the mid corpus callosum over time.

In contrast, higher baseline tau levels were not associated with regional volumetric changes.

Bernick and colleagues previously reported that active fighters have higher serum NfL levels in general compared to retired fighters or control persons. "Thus, the current finding that, within the active fighter group, those with higher baseline NfL levels were more likely to show regional volumetric decline suggests that this measure may have predictive properties in identifying individuals who may be at risk of ongoing structural brain injury," the researchers note.

"Whether cessation of exposure to RHI in those who have elevated NfL levels will halt this volume loss over time needs further investigation," they add.

The researchers found no significant differences in trajectory of cognitive test scores between control persons and active or retired fighters at a group level.

Potential limitations of the study include the fact that it included few women, making it difficult to assess for volume changes by sex. In addition, the average follow-up time was 2.6 years, which may limit the findings.

"Volumetric MRI brain imaging may be able to detect accumulating injury or disease progression in individuals who are exposed to extensive repetitive head impacts," Bernick said.

He added a caveat that the findings need to be validated in other populations in which repetitive head trauma occurs, such as military personnel or athletes who participate in other contact sports.

Going forward, the researchers also might explore whether a multimodal approach that combines volume measures with other potential biomarkers could improve detection of changes at an individual level. Furthermore, if the MRI volumetric measures are validated, they could serve as clinical trial outcomes in future studies of RHIs, Bernick said.

The differences in brain atrophy between active and retired fighters "is intriguing, suggesting that longitudinal MRIs may distinguish between injury responses triggered by recent and remote RHI exposures," Christopher D. Anderson, MD, and Jonathan Rosand, MD, write in an accompanying editorial.

"Atrophy over time in these brain regions could reflect the sequelae of ongoing axonal injury," they note. The decreases in amygdala and hippocampus volumes in the retired fighters could reflect a neurodegerative process, such as that described in Alzheimer disease and chronic traumatic encephalopathy.

They describe the study as "an important advance in the study of athletes subjected to RHI who are at risk for early and long-term neurologic complications." Strengths of the research include a relatively large population, inclusion of people with both recent and remote trauma, and a well-characterized control group, they add.

"Further imaging studies will be needed to replicate and extend these findings," conclude Anderson, who is affiliated with the Henry and Allison McCance Center for Brain Health, the Department of Neurology, and the Center for Genomic Medicine at Massachusetts General Hospital in Boston, and Rosand, who is affiliated with the Program in Medical and Population Genetics at the Broad Institute in Cambridge, Massachusetts.

Bernick received research funding from Ultimate Fighting Championship, Top Rank Promotions, Haymon Boxing, Bellator/Spike TV, and the UCLA Dream Fund. Anderson and Rosand have disclosed no relevant financial relationships.

Neurology. Published online December 23, 2019. Abstract, Editorial

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Neurology Ultrasonic Aspirators to Witness Increase in Revenues by 2019 2027 – Dagoretti News

Posted on February 2, 2020 by Danzig

The Most Recent study on the Neurology Ultrasonic Aspirators Market Research provides a profound comprehension of the various market dynamics like trends, drivers, the challenges, and opportunities. The report further elaborates on the micro and macro-economic elements that are predicted to shape the increase of the Neurology Ultrasonic Aspirators market throughout the forecast period (2019-2029).

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Prognosis for MS changing due to advancements in treatment and awareness, yet access to care is top of mind for neurologists – WFN News

Posted on November 25, 2019 by Danzig

The Prognosis for MS is Changing Due to Advancements in Treatment and Awareness, Yet Access to Care is Top of Mind for Global Neurologists

World Federation of Neurology: November 15, 2019 | London Are regulators keeping up with new treatments and management strategies that can greatly improve the lives of patients with multiple sclerosis (MS)? That question is being debated following the unveiling of significant clinical advances in the diagnostic criteria and treatment of MS at the XXIV World Congress of Neurology (WCN 2019) in Dubai, UAE.

MS has gone from being an untreatable condition to being a manageable disease which is an extraordinary story of achievement, but there is still a long way to go.

MS affects an estimated 2.3 million people around the world, and research shows that access to quality treatment is vital in altering the progression of the disease, especially during the inflammatory part of the disease.

On a global level, there is a concerning gap between the results of clinical trials and regulators approval of advanced therapies, leaving some patients without access to the most effective options.

In fact, therapeutic lags have resulted in entire regions where MS patients will be disabled for longer, due to restrictions or lags in regulatory approvals that restrict doctors from prescribing treatments with the best outcomes.

The understanding of the disease and disease phenotypes are changing, said Prof. Bill Carroll, president of the World Federation of Neurology (WFN) and neurologist at the Department of Neurology and Neurophysiology at the Sir Charles Gairdner Hospital in Perth, Western Australia.

To see improved developments in MS treatment and diagnosis, global awareness and advocacy are in order. International initiatives and awareness will help unlock greater funding for MS research and lead to more effective treatments, says Prof. Thompson.

Our patients should be the number one priority, and its time for neurologists and MS physicians to adopt the approach that they should consider prescribing what is most appropriate for their patients today, despite what restrictions may have put in place yesterday by regulators, said Prof. Carroll.

WCN 2019, hosted by the World Federation of Neurology, brought together leaders in neurology to present new research, hold educational sessions and inspire action on topics ranging from MS and migraine to epilepsy and climate change.

About the World Federation of Neurology

The World Federation of Neurology represents 120 member neurological societies around the globe to foster quality neurology and brain health worldwide by promoting neurological education and training with an emphasis on under-resourced areas of the world. WFN supports the spread of accurate research and clinical information in the pursuit of improvements in the field of neurology. With support from member organizations around the globe, WFN unites the world to allow patients greater access to brain health. For more information, please visit the WCN 2019 web site at http://www.wfneurology.org or by searching using the tag #WCN2019.

Media ContactYakkety Yak ContactAshley Logan, Yakkety Yak LLCpress@yakketyyak.com

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Prognosis for MS changing due to advancements in treatment and awareness, yet access to care is top of mind for neurologists - WFN News

Never before has it been more exciting and important to be a neurologist – Research in progress blog – BMC Blogs Network

Posted on December 10, 2019 by Danzig

Neurological Research and Practice, the official journal of the German Neurological Society, launched its submission system about 1 year ago. Wed like to take this opportunity to talk about hot topics in neurology and the journals first year, with Professor Gereon Fink, Past President of the German Neurological Society.

Victoria Hentschke 9 Dec 2019

What are the current trends and hot topics in neurology?

The increasing insights into the genetics and molecular bases of neurological disorders open new perspectives for specific and personalized treatments. This is evidenced most dramatically by the antisense therapy for spinal muscular atrophy. Promising neurological research currently targets neurodegenerative diseases such as amyotrophic lateral sclerosis, Parkinsons disease, Duchenne muscular atrophy, or Huntingtons disease. Likewise, brain-machine interfaces and neuroprosthetics offer huge potential. Never before has it been more important and more exciting to be a neurologist!

Neurological Research and Practice is celebrating its 1st anniversary of the submission system launch. As the Past President and one of the main drivers for the societys own English-language open access journal, what has the journal achieved so far? Are you happy with the progress you are seeing now?

Within only one year, a new journal has been established with a regular publication schedule of already 3 -4 articles per month with the first articles being published in February 2019. The article accesses of research articles, e.g., Safety and clinical impact of FEES results of the FEES registry, or review articles, e.g., Navigating choice in multiple sclerosis management, demonstrate that the topics covered in the journal meet the readers interests. In addition to review and research articles, standard operating procedures, guidelines, and clinical trial protocols provide a modern style that attracts clinically oriented neuroscientists and neurologists as the target group of Neurological Research and Practice. All this proves that the conceptualization of the journal has been successful. Given the wealth of journals and the competition in the field, we are delighted with the positive reception of Neurological Research and Practice. I would like to congratulate the Editor-in-Chief, Werner Hacke, and his team for the great job they have done.

Lets take a step back why did the DGN wanted to have an open access journal? What was the idea and mission behind the journal?

Without any doubt, neurology is the key discipline in medicine of the 21st century, given the sociodemographic changes of our societies. At the same time, never before in the history of neurology, have we seen such tremendous scientific breakthroughs in basic, clinically relevant neuroscience, translational neurology, and clinical practice. Just think about the significant advances in the treatment of stroke or multiple sclerosis. Thus, bringing together neurological research and practice has proven fruitful. Few journals, however, specifically aim at bridging basic, clinically relevant neuroscience and clinical practice. Neurological Research and Practice, the official journal of the German Neurological Society, exactly aims to do that with a broad scope reflecting all clinical, translational and basic research aspects of neurology and neuroscience. NRP provides a forum for clinicians and scientists with an interest in all areas of neurology including, but not limited to, genetics, vascular diseases and critical care, disorders of the spine, movement disorders, neuroimmunology, infections, oncology, epilepsy, neuroimaging and neuroradiology, neurodevelopment and degeneration.

What are you expecting for the journals future in the next year?

Although online only since February 2019, NRP is already well-perceived, and the first citations speak to the relevance and timeliness of the articles published. The next steps include indexing in the National Library of Medicine (NLM). This will allow access to PubMed and other databases, which will significantly enhance NRPs visibility. Although NRP is the official journal of the German Neurological Society, the journal aims to bring together authors and readers from all countries worldwide. Besides, access to NLM will also be an important step for gaining an impact factor. Given NRPs success over the first few months, we are confident that these important milestones can be achieved in the near future, and hope for this to be within the next 24 months.

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Never before has it been more exciting and important to be a neurologist - Research in progress blog - BMC Blogs Network

USA Health neurologist first in the state to perform new aneurysm procedure – FOX10 News

Posted on December 18, 2019 by Danzig

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A to Z List of Neurological Disorders – Disabled World

Posted on October 19, 2019 by Danzig

Synopsis: Alphabetical list of currently known Human Neurological Conditions including short definitions for each disorder. A neurological disorder is defined as any disorder of the body nervous system. Neurological disorders affect the brain as well as the nerves found throughout the human body and the spinal cord.

A neurological disorder is defined as any disorder of the body nervous system. Structural, biochemical or electrical abnormalities in the brain, spinal cord or other nerves can result in a range of symptoms. Examples of symptoms include paralysis, muscle weakness, poor coordination, loss of sensation, seizures, confusion, pain and altered levels of consciousness. The specific causes of neurological problems vary, but can include genetic disorders, congenital abnormalities or disorders, infections, lifestyle or environmental health problems including malnutrition, and brain injury, spinal cord injury or nerve injury.

There are many recognized neurological disorders, some relatively common, but many rare. They may be assessed by neurological examination, and studied and treated within the specialties of neurology and clinical neuropsychology. Mental disorders, on the other hand, are "psychiatric illnesses" or diseases which appear primarily as abnormalities of thought, feeling or behavior, producing either distress or impairment of function.

Neurological disorders affect the brain as well as the nerves found throughout the human body and the spinal cord. These three parts of the body work together and are referred to as the central nervous system that control everything in the body. Neurology is the medical science that deals with the nervous system and disorders that affect it. Conditions that are classed as mental disorders, or learning disabilities and forms of Intellectual disability, are not themselves usually dealt with as neurological disorders.

Neurological disorders can be categorized according to the primary location affected, the primary type of dysfunction involved, or the primary type of cause. The broadest division is between central nervous system disorders and peripheral nervous system disorders. Neurological disorders can affect an entire neurological pathway or a single neuron. Even a small disturbance to a neuron's structural pathway can result in dysfunction.

According to the University of California, San Francisco, there are more than 600 neurological disorders that strike millions each year. These diseases and disorders inflict great pain and suffering on millions of patients and their families, and cost the U.S. economy billions of dollars annually. Social Security approves disability benefits for serious cases of epilepsy, cerebral palsy, Parkinson's disease, multiple sclerosis, ALS, and other nerve-based diseases.

Diagram of the human brain showing the four lobes - frontal lobe, parietal lobe, occipital lobe, and temporal lobe - of the cerebral cortex. The cerebrum or cortex is the largest part of the human brain, associated with higher brain function such as thought and action.

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Cite:Journal: Disabled World. Language: English. Author: Disabled World. Electronic Publication Date: 2015/04/08. Last Revised Date: 2019/09/23. Reference Title: "A to Z List of Neurological Disorders", Source: A to Z List of Neurological Disorders. Abstract: Alphabetical list of currently known Human Neurological Conditions including short definitions for each disorder. Retrieved 2019-10-19, from https://www.disabled-world.com/health/neurology/disorders-list.php - Reference Category Number: DW#101-11375.

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The Stars in Our Brains – Duke Department of Neurology

Posted on November 4, 2019 by Danzig

More than 10 million people worldwideabout 1 percent of people over age 60live with Parkinsons disease. There are treatments that can help control symptoms, but there is no cure.

The hallmark of the disease is the death of certain brain cellsneurons that produce dopamine. Most Parkinsons researchers have focused on studying these cells. But what if the disease starts elsewhere? What if it involves not only neurons but other cells that interact with neurons? In particular, what role is played by astrocytes, star-shaped cells that nurture and help form the connections, or synapses, between the neurons?

(This article by Angela Spivey, with photos by Alex Boerner, originally appeared in Duke Medical Alumni News. Read that story here.)

Thats the question a team of Duke researchers led by Cagla Eroglu, PhD, associate professor of cell biology and neurobiology, is exploring, thanks to a $1 million grant from the Chan Zuckerberg Initiative.

Sitting in her office, Eroglu picks up an orange plastic object that resembles a piece of coral, its tentacles branching this way and that. This is a model of a mouse astrocyte, she says. It can interact with 100,000 synapses at the same time. Astrocytes, she explains, infiltrate the brain, touching everything within their reach. They communicate with its synapses, regulating blood flow and metabolism.

Astrocytes from the Greek astron, meaning "star"have traditionally been thought of as support cells. But that thinking is changing. Since astrocytes are in such close contact and continuously communicating with synapses, we are beginning to appreciate that they are also fundamentally involved in regulating brain function, Eroglu says.

Collaborating with Albert La Spada, MD, PhD, Eroglu found that a certain gene known to be important in Parkinsons is more highly expressed in astrocytes than in neurons. And when the researchers mutated that gene in astrocytes, they saw some intriguing changes. This still-unpublished work laid the foundation for their proposal to the Chan Zuckerberg Initiative, which is bringing together experimental scientists from divergent fields to take a fresh look at the causes of neurodegenerative disorders.

There are vanishingly few papers that have delved into how astrocytes are contributing to the Parkinsons disease process, says La Spada, professor of neurology and vice chair of research for the Department of Neurology. This is an area that's been under-studied, and I think that the results that we're generating are suggesting that it deserves more attention.In addition to his long experience studying neurodegenerative diseases, La Spada brings expertise in growing astrocytes from induced pluripotent stem cells (IPSCs). That process starts by growing skin cells from a skin biopsy from a Parkinsons patient. Then we use what's called a reprogramming protocol to basically revert them to stem cells that are pluripotent. Once you create the IPSCs, you could use them to make any cell you wanta muscle cell or a cardiac cell or a neuron or an astrocyte, La Spada says. The beauty of this is, it comes from the patient who has the disease of interest."

His labs expertise will only grow because of the Chan Zuckerberg Initiative, which has formed focus groups for grantees around various areas, such as stem cell modeling, CRISPR gene-editing technology, bioinformatic analysis of data sets, and more. We're meeting other researchers from around the world who are doing really unique things. It's a chance for us all to compare notes, and I think this will accelerate all of our endeavors, La Spada says.

Rounding out the team is Nicole Calakos, MD, PhD, a scientist and clinician who treats patients with movement disorders, including Parkinsons. Calakos says that when she first met Eroglu, she was intrigued by her idea that since astrocytes are involved in sculpting the language of neurons, perhaps they play a role in the events that can lead to disease.

Everybody has been fixated like a magnet on the idea that the problem is the neuron that's dying, Calakos says. Cagla said, Hey, let's think outside of the box of that dead cell. Lets consider whether astrocytes are like the soil around a plant, providing the nutrition, and allowing it to form roots, and maybe that is whats broken. Why aren't we even thinking about this critical piece of the brain?

Eroglu puts it this way: Maybe the problem is loss of connections between neurons, even before they die.

Calakos says that part of the reason she came to Duke was the close intermingling of physicians and bench scientists. Because of how the community is at Duke, Cagla and I had been exchanging ideas and collaborating over the years, she says. The Chan Zuckerberg grant is an opportunity to get together as a formal team. I think it's really forward-thinking of them to have teams of basic scientists and practicing physicians all talking to each other.

The Chan Zuckerberg Initiative was launched in December 2015 by Mark Zuckerberg, founder and CEO of Facebook, and Priscilla Chan, a pediatrician and founder and CEO of The Primary School in East Palo Alto. In addition to her clinical insight, Calakos brings expertise in electrophysiologyreal-time recording and observation of electrical signals coming from brain cells. We can listen to the language of synapses, she says. They speak in electrical currents,which we can measure. Eroglu believes that by learning all they can about how astrocytes support synaptic development and health in the normal brain, they may find ways to stop neurodegenerative diseases like Parkinsons.

We are seeing aging as a part of development, Eroglu says. If your house is built on a strong base, then it might last longer. Whereas, if you build it in another way, it may be there for a while, but gradually start to break down.

This doesn't mean that we are destined to have neurodegeneration and we can't do anything. We may be more predisposed to get the disease, but we may not get it if we have done something else in our lives that helps strengthen our brain. I strongly believe that there will be ways to stop neurodegeneration.We will find a way to strengthen the brain connections. If we can figure out the weakest link, then we could concentrate on solving that.

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The Stars in Our Brains - Duke Department of Neurology

Mount Sinai Roosevelt | Department of Neurology

Posted on January 7, 2018 by ev1

The Department of Neurology at Mount Sinai West is a highly-integrated, multidisciplinary department specializing in the evaluation and treatment of people with neurological diseases. Our neurologists are widely respected for their high-quality clinical care and research.

Our physicians make use of the most advanced diagnostics and recent clinical innovations to diagnose and treat very complex and difficult-to-diagnose neurological disorders.

The neurologists at Mount Sinai West provide treatment for people with cancers of the nervous system or with neurologic complications from cancer and its therapies.

We understand the unique nature of many pediatric conditions, including how the tumor and treatment may affect the patients developing brain and neurological development.

We provide treatment for people with cancers of the nervous system or with neurologic complications from cancer and its therapies.

Mount Sinai Wests team of physicians evaluates and treats neurologic and systemic disorders that cause sensory, visual, ocular motor, eyelid, or papillary dysfunctions.

Mount Sinai Wests Neurophysiology department uses the most advanced diagnostic testing in order to evaluate nervous system functioning.

The Stroke Center is a state-of-the-art facility at the forefront of diagnostics and therapies that provides high-quality, compassionate care for life-threatening strokes.

Get answers to the most commonly asked questions about neurological disorders and their treatment.

Meet the highly-trained members of our Neurology department staff.

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Mount Sinai Roosevelt | Department of Neurology

The terrorist inside my husband’s brain | Neurology

Posted on June 3, 2018 by Danzig

I am writing to share a story with you, specifically for you. My hope is that it will help you understand your patients along with their spouses and caregivers a little more. And as for the research you do, perhaps this will add a few more faces behind the why you do what you do. I am sure there are already so many.

This is a personal story, sadly tragic and heartbreaking, but by sharing this information with you I know that you can help make a difference in the lives of others.

As you may know, my husband Robin Williams had the little-known but deadly Lewy body disease (LBD). He died from suicide in 2014 at the end of an intense, confusing, and relatively swift persecution at the hand of this disease's symptoms and pathology. He was not alone in his traumatic experience with this neurologic disease. As you may know, almost 1.5 million nationwide are suffering similarly right now.

Although not alone, his case was extreme. Not until the coroner's report, 3 months after his death, would I learn that it was diffuse LBD that took him. All 4 of the doctors I met with afterwards and who had reviewed his records indicated his was one of the worst pathologies they had seen. He had about 40% loss of dopamine neurons and almost no neurons were free of Lewy bodies throughout the entire brain and brainstem.

Robin is and will always be a larger-than-life spirit who was inside the body of a normal man with a human brain. He just happened to be that 1 in 6 who is affected by brain disease.

Not only did I lose my husband to LBD, I lost my best friend. Robin and I had in each other a safe harbor of unconditional love that we had both always longed for. For 7 years together, we got to tell each other our greatest hopes and fears without any judgment, just safety. As we said often to one another, we were each other's anchor and mojo: that magical elixir of feeling grounded and inspired at the same time by each other's presence.

One of my favorite bedrock things we would do together was review how our days went. Often, this was more than just at the end of the day. It did not matter if we were both working at home, traveling together, or if he was on the road. We would discuss our joys and triumphs, our fears and insecurities, and our concerns. Any obstacles life threw at us individually or as a couple were somehow surmountable because we had each other.

When LBD began sending a firestorm of symptoms our way, this foundation of friendship and love was our armor.

The colors were changing and the air was crisp; it was already late October of 2013 and our second wedding anniversary. Robin had been under his doctors' care. He had been struggling with symptoms that seemed unrelated: constipation, urinary difficulty, heartburn, sleeplessness and insomnia, and a poor sense of smelland lots of stress. He also had a slight tremor in his left hand that would come and go. For the time being, that was attributed to a previous shoulder injury.

On this particular weekend, he started having gut discomfort. Having been by my husband's side for many years already, I knew his normal reactions when it came to fear and anxiety. What would follow was markedly out of character for him. His fear and anxiety skyrocketed to a point that was alarming. I wondered privately, Is my husband a hypochondriac? Not until after Robin left us would I discover that a sudden and prolonged spike in fear and anxiety can be an early indication of LBD.

He was tested for diverticulitis and the results were negative. Like the rest of the symptoms that followed, they seemed to come and go at random times. Some symptoms were more prevalent than others, but these increased in frequency and severity over the next 10 months.

By wintertime, problems with paranoia, delusions and looping, insomnia, memory, and high cortisol levelsjust to name a fewwere settling in hard. Psychotherapy and other medical help was becoming a constant in trying to manage and solve these seemingly disparate conditions.

I was getting accustomed to the two of us spending more time in reviewing our days. The subjects though were starting to fall predominantly in the category of fear and anxiety. These concerns that used to have a normal range of tenor were beginning to lodge at a high frequency for him. Once the coroner's report was reviewed, a doctor was able to point out to me that there was a high concentration of Lewy bodies within the amygdala. This likely caused the acute paranoia and out-of-character emotional responses he was having. How I wish he could have known why he was struggling, that it was not a weakness in his heart, spirit, or character.

In early April, Robin had a panic attack. He was in Vancouver, filming Night at the Museum 3. His doctor recommended an antipsychotic medication to help with the anxiety. It seemed to make things better in some ways, but far worse in others. Quickly we searched for something else. Not until after he left us would I discover that antipsychotic medications often make things worse for people with LBD. Also, Robin had a high sensitivity to medications and sometimes his reactions were unpredictable. This is apparently a common theme in people with LBD.

During the filming of the movie, Robin was having trouble remembering even one line for his scenes, while just 3 years prior he had played in a full 5-month season of the Broadway production Bengal Tiger at the Baghdad Zoo, often doing two shows a day with hundreds of linesand not one mistake. This loss of memory and inability to control his anxiety was devastating to him.

While I was on a photo shoot at Phoenix Lake, capturing scenes to paint, he called several times. He was very concerned with insecurities he was having about himself and interactions with others. We went over every detail. The fears were unfounded and I could not convince him otherwise. I was powerless in helping him see his own brilliance.

For the first time, my own reasoning had no effect in helping my husband find the light through the tunnels of his fear. I felt his disbelief in the truths I was saying. My heart and my hope were shattered temporarily. We had reached a place we had never been before. My husband was trapped in the twisted architecture of his neurons and no matter what I did I could not pull him out.

In early May, the movie wrapped and he came home from Vancouverlike a 747 airplane coming in with no landing gear. I have since learned that people with LBD who are highly intelligent may appear to be okay for longer initially, but then, it is as though the dam suddenly breaks and they cannot hold it back anymore. In Robin's case, on top of being a genius, he was a Julliard-trained actor. I will never know the true depth of his suffering, nor just how hard he was fighting. But from where I stood, I saw the bravest man in the world playing the hardest role of his life.

Robin was losing his mind and he was aware of it. Can you imagine the pain he felt as he experienced himself disintegrating? And not from something he would ever know the name of, or understand? Neither he, nor anyone could stop itno amount of intelligence or love could hold it back.

Powerless and frozen, I stood in the darkness of not knowing what was happening to my husband. Was it a single source, a single terrorist, or was this a combo pack of disease raining down on him?

He kept saying, I just want to reboot my brain. Doctor appointments, testing, and psychiatry kept us in perpetual motion. Countless blood tests, urine tests, plus rechecks of cortisol levels and lymph nodes. A brain scan was done, looking for a possible tumor on his pituitary gland, and his cardiologist rechecked his heart. Everything came back negative, except for high cortisol levels. We wanted to be happy about all the negative test results, but Robin and I both had a deep sense that something was terribly wrong.

On May 28th, he was diagnosed with Parkinson disease (PD).

We had an answer. My heart swelled with hope. But somehow I knew Robin was not buying it.

When we were in the neurologist's office learning exactly what this meant, Robin had a chance to ask some burning questions. He asked, Do I have Alzheimer's? Dementia? Am I schizophrenic? The answers were the best we could have gotten: No, no, and no. There were no indications of these other diseases. It is apparent to me now that he was most likely keeping the depth of his symptoms to himself.

Robin continued doing all the right thingstherapy, physical therapy, bike riding, and working out with his trainer. He used all the skills he picked up and had fine-tuned from the Dan Anderson retreat in Minnesota, like deeper 12-step work, meditation, and yoga. We went to see a specialist at Stanford University who taught him self-hypnosis techniques to quell the irrational fears and anxiety. Nothing seemed to alleviate his symptoms for long.

Throughout all of this, Robin was clean and sober, and somehow, we sprinkled those summer months with happiness, joy, and the simple things we loved: meals and birthday celebrations with family and friends, meditating together, massages, and movies, but mostly just holding each other's hand.

Robin was growing weary. The parkinsonian mask was ever present and his voice was weakened. His left hand tremor was continuous now and he had a slow, shuffling gait. He hated that he could not find the words he wanted in conversations. He would thrash at night and still had terrible insomnia. At times, he would find himself stuck in a frozen stance, unable to move, and frustrated when he came out of it. He was beginning to have trouble with visual and spatial abilities in the way of judging distance and depth. His loss of basic reasoning just added to his growing confusion.

It felt like he was drowning in his symptoms, and I was drowning along with him. Typically the plethora of LBD symptoms appear and disappear at random timeseven throughout the course of a day. I experienced my brilliant husband being lucid with clear reasoning 1 minute and then, 5 minutes later, blank, lost in confusion.

Prior history can also complicate a diagnosis. In Robin's case, he had a history of depression that had not been active for 6 years. So when he showed signs of depression just months before he left, it was interpreted as a satellite issue, maybe connected to PD.

Throughout the course of Robin's battle, he had experienced nearly all of the 40-plus symptoms of LBD, except for one. He never said he had hallucinations.

A year after he left, in speaking with one of the doctors who reviewed his records, it became evident that most likely he did have hallucinations, but was keeping that to himself.

It was nearing the end of July and we were told Robin would need to have inpatient neurocognitive testing done in order to evaluate the mood disorder aspect of his condition. In the meantime, his medication was switched from Mirapex to Sinemet in an effort to reduce symptoms. We were assured Robin would be feeling better soon, and that his PD was early and mild. We felt hopeful again. What we did not know was that when these diseases start (are diagnosed) they have actually been going on for a long time.

By now, our combined sleep deficit was becoming a danger to both of us. We were instructed to sleep apart until we could catch up on our sleep. The goal was to have him begin inpatient testing free of the sleep-deprived state he was in.

As the second weekend in August approached, it seemed his delusional looping was calming down. Maybe the switch in medications was working. We did all the things we love on Saturday day and into the evening, it was perfectlike one long date. By the end of Sunday, I was feeling that he was getting better.

When we retired for sleep, in our customary way, my husband said to me, Goodnight, my love, and waited for my familiar reply: Goodnight, my love.

His words still echo through my heart today.

Monday, August 11, Robin was gone.

After Robin left, time has never functioned the same for me. My search for meaning has replicated like an inescapable spring throughout nearly every aspect of my world, including the most mundane.

Robin and I had begun our unplanned research on the brain through the door of blind experience. During the final months we shared together, our sights were locked fast on identifying and vanquishing the terrorist within his brain. Since then, I have continued our research but on the other side of that experience, in the realm of the science behind it.

Three months after Robin's death, the autopsy report was finally ready for review. When the forensic pathologist and coroner's deputy asked if I was surprised by the diffuse LBD pathology, I said, Absolutely not, even though I had no idea what it meant at the time. The mere fact that something had invaded nearly every region of my husband's brain made perfect sense to me.

In the year that followed, I set out to expand my view and understanding of LBD. I met with medical professionals who had reviewed Robin's last 2 years of medical records, the coroner's report, and brain scans. Their reactions were all the same: that Robin's was one of the worst LBD pathologies they had seen and that there was nothing else anyone could have done. Our entire medical team was on the right track and we would have gotten there eventually. In fact, we were probably close.

But would having a diagnosis while he was alive really have made a difference when there is no cure? We will never know the answer to this. I am not convinced that the knowledge would have done much more than prolong Robin's agony while he would surely become one of the most famous test subjects of new medicines and ongoing medical trials. Even if we experienced some level of comfort in knowing the name, and fleeting hope from temporary comfort with medications, the terrorist was still going to kill him. There is no cure and Robin's steep and rapid decline was assured.

The massive proliferation of Lewy bodies throughout his brain had done so much damage to neurons and neurotransmitters that in effect, you could say he had chemical warfare in his brain.

One professional stated, It was as if he had cancer throughout every organ of his body. The key problem seemed to be that no one could correctly interpret Robin's symptoms in time.

I was driven to learn everything I could about this disease that I finally had the name of. Some of what I learned surprised me.

One neuropathologist described LBD and PD as being at opposite ends of a disease spectrum. That spectrum is based on something they share in common: the presence of Lewy bodiesthe unnatural clumping of the normal protein, -synuclein, within brain neurons. I was also surprised to learn that a person is diagnosed with LBD vs PD depending on which symptoms present first.

After months and months, I was finally able to be specific about Robin's disease. Clinically he had PD, but pathologically he had diffuse LBD. The predominant symptoms Robin had were not physicalthe pathology more than backed that up. However you look at itthe presence of Lewy bodies took his life.

The journey Robin and I were on together has led me to knowing the American Academy of Neurology and other groups and doctors. It has led me to discover the American Brain Foundation, where I now serve on the Board of Directors.

This is where you come into the story.

Hopefully from this sharing of our experience you will be inspired to turn Robin's suffering into something meaningful through your work and wisdom. It is my belief that when healing comes out of Robin's experience, he will not have battled and died in vain. You are uniquely positioned to help with this.

I know you have accomplished much already in the areas of research and discovery toward cures in brain disease. And I am sure at times the progress has felt painfully slow. Do not give up. Trust that a cascade of cures and discovery is imminent in all areas of brain disease and you will be a part of making that happen.

If only Robin could have met you. He would have loved younot just because he was a genius and enjoyed science and discovery, but because he would have found a lot of material within your work to use in entertaining his audiences, including the troops. In fact, the most repeat character role he played throughout his career was a doctor, albeit different forms of practice.

You and your work have ignited a spark within the region of my brain where curiosity and interest lie and within my heart where hope lives. I want to follow you. Not like a crazed fan, but like someone who knows you just might be the one who discovers the cure for LBD and other brain diseases.

Thank you for what you have done, and for what you are about to do.

Susan Schneider Williams serves on the Board of Directors for the American Brain Foundation (americanbrainfoundation.org) but reports no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.

Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the author, if any, are provided at the end of the editorial.

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Neurology Services NYC | Mount Sinai – New York

Posted on June 19, 2018 by Danzig

When it comes to finding care for a neurological condition, you want the best medicine, backed by the newest research, and delivered by highly skilled doctors who take the time to develop a relationship with you and your family.We believe every patient who walks through our door deserves exactly that combination of science and personalized attention whether you are an inpatient seen by one of our neurohospitalists or are seeking outpatient care at one of our many locations.

Our approach starts simply: We listen to you. After hearing about your symptoms and answering your questions, well guide you through the most advanced testing to make a thorough and accurate diagnosis. From there, we offer the newest treatment options, informed by innovative research conducted right here at the Icahn School of Medicine at Mount Sinai.Our physicians specialize in the full range of neurological conditions in children, adolescents, and adults including stroke, epilepsy, headache, Parkinsons disease, multiple sclerosis, brain and spinal tumors, Alzheimers disease, and amyotrophic lateral sclerosis (ALS) and work with a trained team of nurses, social workers, neuropsychologists and others to customize the right treatment plan for you and your family.

The Mount Sinai Health System is an internationally recognized leader in clinical neurology,neurology education, and neurology research.

With high 2017-2018 rankings fromU.S. News & World Report, our Department is committed to combining our scientific expertise with the compassionate, individualized attention you need to enjoy the best possible health.

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Neurology | Michigan Medicine | University of Michigan

Posted on November 22, 2017 by ev1

Welcome: A Message from Dr. Fink, Chair

The brain makes us who we are, largely defining our uniqueness as individuals and as a species. For this reason diseases that attack the nervous system - whether suddenly as in stroke, insidiously as in Alzheimer's disease, or with recurrent attacks as may occur in multiple sclerosis - strike at the core of our being. Imagine being unable to speak, being unable to move your limbs at will, or experiencing difficulty recognizing common surroundings or close relatives.

In the Department of Neurology at the University of Michigan, a dedicated team of academic neurologists pursues the three-part academic mission of clinical care, research and education. Highly skilled physicians with subspecialty expertise in each of the domains of adult neurology provide care to patients with diseases of the nervous system in both hospital and outpatient settings. Many of these physicians direct laboratory or clinical research programs to advance our understanding of neurological disease, and to develop and test new therapies for these diseases.

David J. Fink, M.D.Robert Brear Professor and Chair

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Neurology | Michigan Medicine | University of Michigan

Neurologist: Definition, Treatments Areas, and More

Posted on November 20, 2017 by ev1

A neurologist is a medical doctor who specializes in treating diseases of the nervous system. The nervous system is made of two parts: the central and peripheral nervous system. It includes the brain and spinal cord.

Illnesses, disorders, and injuries that involve the nervous system often require a neurologists management and treatment.

Before they can practice, neurologists must:

Neurologists manage and treat neurological conditions, or problems with the nervous system. Symptoms that commonly require a neurologist include:

People who are having problems with their senses, such as touch, vision, or smell, may also need to see a neurologist. Problems with senses are sometimes caused by nervous system disorders.

Neurologists also see patients with:

Because the nervous system is complex, a neurologist may specialize in a specific area. They will do a fellowship in that area after residency training. Subspecialties have evolved to narrow a doctors focus.

There are many subspecialties. Some examples of subspecialties include:

During your first appointment with a neurologist, they will likely perform a physical exam and a neurological exam. A neurological exam will test muscle strength, reflexes, and coordination. Since different disorders can have similar symptoms, your neurologist may need more testing to make a diagnosis.

Neurologists may recommend a variety of procedures to help diagnose or treat a condition. These procedures may include:

Your neurologist may use a lumbar puncture to test your spinal fluid. They may recommend the procedure if they believe your symptoms are caused by a problem in your nervous system that can be detected in your spinal fluid. The procedure involves inserting a needle into the spine after numbing it and taking a sample of spinal fluid.

This procedure can help your neurologist diagnose myasthenia gravis. In this test, your doctor injects you with a medicine called Tensilon. Then they observe how it affects your muscle movements.

By applying electrodes to your scalp, this test measures electrical activity in the brain.

Neurologists may use other types of tests, as well. Although they may not perform the test, they may order it, review it, and interpret the results.

To make a diagnosis, a neurologist may use imaging tests such as:

Other diagnostic procedures include sleep studies and angiography. Angiography determines blockages in the blood vessels going to the brain.

Your neurologist may help you manage your symptoms and neurological disorder alone, or with your primary care physician and other specialists.

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Neurologist: Definition, Treatments Areas, and More

Patients Receiving Treatment for MS Have Increased Risk for Any Infection – Neurology Advisor

Posted on February 29, 2020 by Danzig

WEST PALM BEACH Patients who have been diagnosed with and treated for multiple sclerosis (MS) have an increased risk for any type of infection, and are more frequently hospitalized because of infections compared with their health counterparts, according to research presented at the Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) 2020 Forum held from February 27 to 29, 2020, in West Palm Beach, Florida. Results further showed that the highest increased risk was associated with renal tract infection.

Previous research has suggested that patients with MS have an increased risk for infection; therefore, the current study was designed to describe infection rates in this patient population using data from the United States Department of Defense database. Patients who were diagnosed with MS >1 year ago and were receiving treatment for this illness between January 2004 and August 2017 (n=8695) were matched with control patients without MS (n=86,934) by sex, age, and geographic region. Infections recorded after MS diagnosis were identified and incidence rates and incidence rate ratios (IRRs) of infection type and first infection were calculated.

During a median 7 years of follow-up, participants with MS had higher infection rates (any infection, diagnoses combined) (IRR, 1.76; 95% CI, 1.72-1.80) and hospitalized infections (IRR, 2.43; 95% CI, 2.23-2.63). Compared with matched controls, patients with MS had a higher incidence rate of first renal tract infection (IRR, 1.88; 95% CI, 1.81-1.95); skin infections (IRR, 1.51; 95% CI, 1.45-1.58); fungal infections (IRR, 1.47; 95% CI, 1.41-1.53); pneumonia and influenza (IRR, 1.48; 95% CI, 1.40-1.56); as well as other types of infection including helminthiases, rickettsioses, spirochetal diseases, nonsyphilitic and nongonococcal venereal diseases, and parasitic infections and infestations (IRR, 1.68; 95% CI, 1.61-1.75).

Incidence rate ratios of eye, ear, respiratory, throat, and viral infections were only marginally elevated. Results also demonstrated that rates of renal tract infections were more than 4-fold higher among women compared with men in both groups, but the IRR was higher in men (IRR, 2.47; 95% CI, 2.22-2.75) than women (IRR, 1.90; 95% CI, 1.83-1.98).

The investigators concluded, Treated MS patients have an increased risk of any infections. Hospitalized infections were also increased in MS patients. Most infection types were increased in MS patients with the highest risk associated with renal tract infections.

Visit Neurology Advisors conference section for continuous coverage from the ACTRIMS 2020 Forum.

Reference

Jick S, Persson R, Ulcickas M, et al. Increased risk of infections in patients diagnosed with and treated for multiple sclerosis: A study using the US Department of Defense Database. Presented at: ACTRIMS Forum 2020; February 27-29, 2020; West Palm Beach, FL. Abstract P086.

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Patients Receiving Treatment for MS Have Increased Risk for Any Infection - Neurology Advisor

Interventional Neurologists Converting to Transradial Access – Medscape

Posted on March 9, 2020 by Danzig

LOS ANGELES The safety advantage that has already coaxed U.S. interventional cardiologists to switch many of their routine catheterizations from femoral-artery entry in the groin to a radial-artery approach through a patient's wrist is now prompting a similar shift among U.S. interventional neurologists, who are increasingly pivoting to transradial access when performing many neurovascular procedures.

"It's growing dramatically in U.S. practice. It may be hype, but there is big excitement. We are still in an assessment mode, but the adoption rate has been high,"Raul G. Nogueira, MD, said in an interview during the International Stroke Conference sponsored by the American Heart Association.

"The big advantage [of transradial catheterization entry] is elimination of groin complications, some of which can be pretty bad. Is it safe for the brain? It's probably okay, but that needs more study," said Dr. Nogueira, professor of neurology at Emory University and director of the Neurovascular Service at the Grady Marcus Stroke and Neuroscience Center in Atlanta.

His uncertainty stems from the more difficult route taken to advance a catheter from the wrist into brain vessels, a maneuver that requires significant manipulation of the catheter tip, unlike the path from the right radial artery into the heart's arteries, a "straight shot," he explained.

To reach the brain's vasculature, the tip must execute a spin "that may scrape small emboli from the arch or arteries, so we need to look at this a little more carefully," ideally in a prospective, randomized study, he said. "We need to see whether the burden of [magnetic resonance] lesions is any higher when you go through the radial [artery]."

Some of the first-reported, large-scale U.S. experiences using a radial-artery approach for various neurovascular procedures, including a few thrombectomy cases, came in a series of 1,272 patients treated at any of four U.S. centers during July 2018 to June 2019, a period when the neurovascular staffs at all four centers transitioned from primarily using femoral-artery access to using radial access as their default mode.

During the 12-month transition period, overall use of radial access at all four centers rose from roughly a quarter of all neurovascular interventions during July to September 2018 to closer to 80% by April to June 2019,Eyad Almallouhi, MD, reported at the conference.

During the entire 12 months, the operators ran up a 94% rate of successfully completed procedures using radial access, a rate that rose from about 88% during the first quarter to roughly 95% success during the fourth quarter tracked, said Dr. Almallouhi, a neurologist at the Medical University of South Carolina in Charleston.

The rate of crossover from what began as a transradial procedure but switched to transfemoral was just under 6% overall, with a nearly 14% crossover rate during the first quarter that then dropped to around 5% for the rest of the transition year. Crossovers for interventional procedures throughout the study year occurred at a 12% rate, while crossovers for diagnostic procedures occurred at a 5% clip throughout the entire year.

None of the transradial patients had a major access-site complication, and minor complications occurred in less than 2% of the patients, including 11 with a forearm hematoma, 6 with forearm pain, and 5 with oozing at their access site. The absence of any major access-site complications among the transradial-access patients in this series contrasts with a recent report of a 1.7% rate of major complications secondary to femoral-artery access for mechanical thrombectomy in a combined analysis of data from seven published studies that included 660 thrombectomy procedures (Am J Neuroradiol. 2019 Feb.doi: 10.3174/ajnr.A6423).

The other three centers that participated in the study Dr. Almallouhi presented were the University of Miami, Thomas Jefferson University in Philadelphia, and the University of Pittsburgh.

Of the 1,272 total procedures studied, 83% were diagnostic procedures, which had an overall 95% success rate, and 17% were interventional procedures, which had a success rate of 89%. The interventional transradial procedures included 62 primary coilings of aneurysms, 44 stent-assisted aneurysm coilings, 40 patients who underwent a flow diversion, 21 balloon-assisted aneurysm coilings, and 24 patients who underwent stroke thrombectomy.

The size of the devices commonly used for thrombectomy are often too large to allow for radial-artery access, noted Dr. Nogueira. For urgent interventions like thrombectomy "we use balloon-guided catheters that are large-bore and don't fit well in the radial," he said, although thrombectomy via the radial artery without a balloon-guided catheter is possible for clots located in the basilar artery. Last year, researchers in Germany reported using a balloon-guided catheter to perform mechanical thrombectomy via the radial artery (Interv Neuroradiol. 2019 Oct 1;25[5]:508-10).

But it's a different story for elective, diagnostic procedures. "I have moved most of these to transradial," Dr. Nogueira said. He and his coauthors summarized the case for transradial access for cerebral angiography in a recent review; in addition to enhanced safety they cited other advantages including improved patient satisfaction and reduced cost because of a shorter length of stay (Interv Cardiol Clin. 2020 Jan;9[1]:75-86).

Despite his enthusiasm and the enthusiasm of other neurointerventionalists for the transradial approach, other stroke neurologists have been more cautious and slower to shift away from the femoral approach.

"Our experience has been that for most cases it's a bit more challenging to access the cervical vessels from the radial artery than from the traditional femoral approach. For arches with complex anatomy, however, the transradial approach can be of benefit in some cases, depending on the angles that need to be traversed," commentedJeremy Payne, MD, director of the Banner Center for Neurovascular Medicine and medical director of the BannerUniversity Medical Center Phoenix Comprehensive Stroke Program. Dr. Payne highlighted that, while he is not an interventionalist himself, he and his interventional staff have regularly discussed the transradial option.

"In the cardiology literature the radial approach has been very successful, with better overall safety than the traditional femoral approach. Largely this seems to do with the anatomy of the aortic arch. It's simply a more direct approach to the coronaries via the right radial artery; getting the wire into the correct vessel is significantly more difficult the more acute the angle it has to traverse," such as when the target is an intracerebral vessel, Dr. Payne said in an interview.

"Our experience in the past 6 months has been about 25% transradial for some of our procedures, mainly diagnostic angiograms. We don't find any difference in safety, however, as our transfemoral procedures are already very safe. One of the benefits of a transradial approach has been that a closure device may not be needed, with fewer vascular complications at the access site, such as fistula formation. We use ultrasound for access, and have not seen a difference in those approaches at all so far. One might argue that using ultrasound to establish access would slow us down, but so far our fastest case start-to-recanalization time in an acute stroke this year was 6 minutes, so speed does not appear to be a limiting issue.

"Another concern overall for transradial access is the potential limitation in the tools we may be able to deploy, given the smaller size of the vessel. It is reassuring [in the report from Dr. Almallouhi] that a variety of cases were successfully completed via this approach. However, fewer than 2% of their cases [24 patients] were apparently emergent, acute strokes, lending no specific support to that context. I do not expect that to change based on this paper," Dr. Payne concluded.

"It is not clear to me that transradial neurointervention will change much. We have excellent safety data for the femoral approach, a proven track record of efficacy, and for most patients it seems to afford a somewhat wider range of tools that can be deployed, with simpler anatomy for accessing the cervical vessels in most arches. It is reassuring that the results reported by Dr. Almallouhi did not suggest negative outcomes, and as such I suspect the transradial approach at least gives us an additional option in a minority of patients. We have seen in the past 5-10 years an explosion of tools for the endovascular treatment of stroke; transradial access represents another potential strategy that appears so far to be safe," Dr. Payne said.

Drs. Nogueira, Almallouhi, and Payne had no relevant disclosures.

International Stroke Conference (ISC) 2020: Abstract 64. Presented February 19, 2020.

This article originally appeared on MDedge.com.

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Crowdsourcing the Next Big Neurology Study Novel Approaches to Cull ‘Big Data’ – LWW Journals

Posted on August 21, 2017 by Danzig

ARTICLE IN BRIEF

From basic research using a mouse cortex to the search for detecting early signs of seizures, investigators are using crowdsourcing techniques to elicit more data and answers to basic and clinical neurology questions. Here, they discuss the challenges and opportunities of next-generation research techniques.

Increasingly, researchers are using crowdsourcing techniques to cull data from a broader array of sources, using everything from smart watches that track respiration to holding contests to develop better algorithms for predicting seizures.

The investigators say that crowdsourcing for data enables easier access to huge datasets, faster development, and larger outreach to other researchers. But it's not as simple as launching an app and putting the data online.

Data collection is tricky, and everyone does it a little differently even on the same subject, several investigators told Neurology Today. Holding contests to find algorithmic answers to neurologic problems might seem novel now, but what happens when interests die out? And focusing on specific goal-oriented research requires a dramatic change in how the government and academic institutions reward progress.

Problems can emerge when people input and extract the data in inconsistent ways, for example. There's data in and there's data out, and there are issues on both ends, said Joshua T. Vogelstein, PhD, an assistant professor of biomedical engineering at Johns Hopkins University and its Institute for Computational Medicine. Dr. Vogelstein is a co-founder with his brother, computer scientist Randal Burns, of the Open Connectome Project, which stores large-scale neurologic data in the cloud, to allow scientists to generate and test theories of brain function and dysfunction.

The project, which includes 10 terabytes images from a mouse cortex dataset, is all online and open for free, and so is the code that everyone is writing to do the analysis. The cloud-based data enables users to view and analyze the images to identify neurons and synapses using special image-processing tools, and then help annotate them.

In creating the project, Dr. Vogelstein said the developers learned that they needed to create a template, so that all the data would fit the same standards. Now when someone sends data for the project, Dr. Vogelstein's team writes a customized script so that it will inject into the database.

Doctors should never have to learn how to code, like I shouldn't have to learn how to do surgery, said Dr. Vogelstein. But we have to work together to find an appropriate middle ground.

David S. Liebeskind, MD, FAAN, FAHA, FANA, professor of neurology and director of the Neurovascular Imaging Research Core at the University of California, Los Angeles department of neurology, views crowdsourcing as a vehicle for changing the focus of research from the traditional clinical approach.

The focus is not just on the hospital, but going to where the patients are, going to the individual level, he said. The focus is on longitudinal outcomes and not as much on the acute inpatient admission to an academic medical center where the individual has a specific complaint.

With so many people wearing activity monitors and carrying smart phones, a lot of the data are worthwhile and helpful at an individual level, he said. But he acknowledged that with open sharing and access to data, there are concerns about the validity and quality of the data, as well as protecting the confidentiality of information from participants. It's not enough to pull in the data, a framework or context is important to interpret the data, he said

In a 2016 paper in Frontiers in Neuroscience, Dr. Liebeskind proposed A Million Brains Initiative, aimed at collecting imaging data on the brain and vessels to advance stroke research and vascular substrates of dementia. The project requires that individuals upload their brain imaging data to a secure cloud, which could then be developed into a searchable and scalable platform.

Despite such variability in the type of data available and other limitations, the data hierarchy logically starts with imaging and can be enriched with almost endless types and amounts of other clinical and biological data, he wrote. Crowdsourcing allows an individual to contribute to aggregated data on a population, while preserving their right to specific information about their own brain health.

But he said many patients may be unaware of their right to access and obtain their medical images.

Benjamin H. Brinkmann, PhD, assistant professor of neurology biomedical engineering at the Mayo Clinic in Rochester, MN, already had the data, but wanted a better way to use it. Dr. Brinkmann, along with Brian Litt, MD, director of the Center for Neuroengineering and Therapeutics at the University of Pennsylvania, hosted an online competition to develop computer algorithms to detect, predict, and ultimately prevent epileptic seizures.

Hosted by the online platform Kaggle, more than 500 teams worked with shared datasets from a collaborative project with a startup company NeuroVista, and from research epilepsy recordings taken at Mayo Clinic. The contest made the recordings available on the International Epilepsy Electrophysiology Portal, http://www.ieeg.org, a National Institute for Neurological Disorders and Stroke-funded data-sharing platform for collaborative neuroscience research hosted by the University of Pennsylvania. The results of the contest were reported at last year's annual meeting of the American Epilepsy Society.

About $40 million had been spent over 15 years to find a program to predict seizures, with the best results reaching 65 percent, said Dr. Litt. The best result from the crowdsourcing contest reached 84 percent in three months. The top prize was $15,000.

There were pros and cons [to this approach], but overall it was a big success, and it helped us explore so many algorithms and figure out what features we needed to pull out of the data it helped us see past the noise, Dr. Brinkmann said.

The challenge with contests, said Dr. Vogelstein of Johns Hopkins, is that the situation is usually so specific that the algorithm often can't be used in other, similar scenarios and datasets. But Dr. Litt said contests require participants to design the work, specifically the data and the framework, so that it can be used much more widely.

Dr. Brinkmann said one of the winning entries in the algorithm contest for seizure detection was from a man in Israel who had his own company that predicts colon cancer. Although the contest stipulated that the winning algorithm would be released publicly, the man decided to patent his answer instead, and he was disqualified.

The team is adapting the winning answer as part of their current grant project, and, Dr. Vogelstein said, the project will require a fair bit of rewriting.

Although the results may need fine-tuning, Dr. Litt said the crowdsourcing contests drastically changed his thoughts on research objectives and academic success. Where the incentive has been focusing on obtaining large grants or being named first or last on an authored publication, the focus should be on obtaining actual solutions and sharing the information, he said.

If you want to find a way to track epileptic seizures, you want people to solve the problem, not focus on the progress of one individual, said Dr. Litt, who is helping to build an Open Data Ecosystem for Neuroscience, a project that is enlisting multiple centers to share data, collaborate, and crowdsource on the best methods for surgery to treat epileptic seizures.

All the data should be posted and be completely transparent, so other people can validate it, he said. People could use the data, and credit you, like a publication, and you would be promoted and given funding based on your record of sharing, collaborating, and how many people use and quote your data.

Our goal is nothing short of changing the fabric of science, and changing the way research is funded, Dr. Litt said.

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Crowdsourcing the Next Big Neurology Study Novel Approaches to Cull 'Big Data' - LWW Journals

One of longest tenured nonprofit CEOs retiring on a strong note – Minneapolis Star Tribune

Posted on February 10, 2020 by Danzig

Catherine Rydell, CEO of the American Academy of Neurology (AAN), said she never felt qualified for any of her jobs but believes in raising your hand and saying yes to opportunities. Yet when she retires in May, her 21-year tenure will be one of the longest among Minnesota nonprofit leaders.

Before joining the AAN, she was a volunteer leader as a stay-at-home mom who then became a state legislator in North Dakota. She believes that empowering her staff and giving them opportunities of their own is how the AAN has become the largest association for neurologists, with 36,000 members.

Mary Post, executive director of the American Board of Anesthesiology, will take over for Rydell.

Q: How is the AAN of 2020 different from the organization you were chosen to lead in 1999?

A: In 1999, I became the third executive director and the first woman to hold the position. When I arrived, the board had just approved its first strategic plan but was focused more on operations. With the help of some key board members, we were able to evolve the governing body to be much more strategically focused. As programs and services for members grew, we expanded staff, led by a competent and innovative executive team. Continual strategic planning has become the norm, backed by data, member input and environmental scans, which tip us off to new trends and concerns. This enables us to be more proactive, rather than reactive, which is critical in the rapidly shifting health care environment.

Q: How has the field of neurology changed in 20 years and what demands has that placed on AAN?

A: The AAN was founded in 1948 by Dr. A.B. Baker, who chaired the neurology department at the University of Minnesota. He started it to provide support and continuing medical education to young neurologists who were going into practice.

That need for support, not only for practicing neurologists but for those in academic institutions and in research, has significantly grown as the health care environment has become more complicated and challenging.

Today, the AAN has more than 36,000 members with 28,000 of those in the U.S. and serves as the worlds largest association of neurologists to help the one in six people worldwide affected by neurologic disease, such as stroke, Alzheimers disease, migraine, Parkinsons disease, concussion, MS, and epilepsy.

Our education and science programs at our annual meetings attract as many as 15,000 attendees. We advocate in Washington, D.C., to reduce the administrative burdens that regulations place on our practicing neurologists. We also advocate for increases in funding for the National Institutes of Health and the BRAIN Initiative so we can speed up the cures and treatments needed for more than 600 brain diseases. And we also help our academic neurologists find greater efficiencies and improvements in care for their patients.

Q: How has membership changed in the last 20 years?

A: One of the most significant aspects is that we have very strong retention rates among our U.S. members, currently at 95%. Our members feel they are getting their moneys worth from the AAN, and 83 cents of every dollar in dues goes back to our members in the form of benefits, programs and services. We represent 93% of all neurologists in the U.S. And we have more than 8,000 members from 141 countries.

We have also taken a more holistic approach to recognizing that the neurologist is a member of a care team. Its becoming more the norm that when you see a neurologist, you first see an advanced practice provider who has training in neurology fundamentals and can provide more of the basic services before the neurologist comes to the exam room. We now have more than 1,400 advanced practice providers as members, and we have tailored education programs for them. We also have 300 neurology business administrators as members; they fill the crucial role of keeping our members practices running efficiently, and we have programs and services to help them in their clinics and institutions.

We have seen more women come into neurology, from 29% of our membership in 2008 to 40% in 2019. Women and minority neurologists still face obstacles in the workplace because of gender and race. AAN has developed training programs to address those challenges, and we have created leadership programs to ensure that the leadership of the AAN and neurology in general is broad-based and representative.

Q: How have the publication and convention businesses contributed to the growth of the organization. How have they grown and why are they important to the membership and organization?

A: Members receive our eight publications, including the Neurology medical journal and Brain & Life magazine for patients (its free for the public) as either a membership benefit or a deeply discounted subscription rate. The revenue from our publications is a significant portion of our total revenue, which helps us keep member dues low and provide neurologists the services they need.

Our signature event of the AAN since 1949 has been our annual meeting, which has grown to become the worlds largest gathering of neurology professionals, with over 15,000 attendees. The last time we held our annual meeting in Minneapolis was in 1998, for our 50th anniversary. Since then, we have grown too large for the number of hotel rooms the downtown area can provide. However, this summer we will be holding our Sports Concussion Conference here and expect as many as 500 attendees.

Our meetings not only bring together the best and brightest experts to teach, inform and inspire attendees, they also offer networking opportunities and camaraderie.

Q: Tell us about your successor and the challenges she and the organization will likely face in the next 20 years.

A: Mary Post was selected based on her extensive experience as a CEO of the American Board of Anesthesiology (ABA), as well as her broad experience at the American Academy of Neurology, where she served for 16 years (19922008) in many leadership roles, including a deputy executive director. We are happy to have Mary come home.

Q: What are next steps for you: traditional retirement or an encore career?

A: Im truly looking forward to spending more time with family, friends, and enjoying lake life. But I also know that I am intrigued by a challenge. As they say, never say never.

Patrick Kennedy 612-673-7926

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One of longest tenured nonprofit CEOs retiring on a strong note - Minneapolis Star Tribune

Russia Neurology Procedures Outlook Over the Period, 2015-2025 – ResearchAndMarkets.com – Yahoo Finance

Posted on February 17, 2020 by Danzig

The "Russia Neurology Procedures Outlook to 2025 - Hydrocephalus Shunting Procedures, Neurovascular Thrombectomy Procedures, ICP Procedures and Others." report has been added to ResearchAndMarkets.com's offering.

Russia Neurology Procedures Outlook to 2025 - Hydrocephalus Shunting Procedures, Neurovascular Thrombectomy Procedures, ICP Procedures and Others.

Summary

The publisher's new report, Russia Neurology Procedures Outlook to 2025, provides key procedures data on the Russia Neurology Procedures. The report provides procedure volumes within market segments - Hydrocephalus Shunting Procedures, Neurovascular Thrombectomy Procedures, Neurovascular Embolization Procedures, Neurovascular Coiling Assist Procedures, Neurovascular Accessory Procedures, Intracranial Stenting Procedures, ICP Procedures, Dura Substitute Procedures, Neuromodulation Procedures and Minimally Invasive Neurosurgery Procedures.

The data in the report is derived from dynamic market forecast models. The publisher uses epidemiology based models to estimate and forecast the procedure volumes. The objective is to provide information that represents the most up-to-date data of the industry possible.

The epidemiology-based forecasting model makes use of epidemiology data gathered from research publications and primary interviews with physicians to establish the target patient population and treatment flow patterns for individual diseases and therapies. Using prevalence and incidence data and diagnosed and treated population, the epidemiology-based forecasting model arrives at the final numbers.

Extensive interviews are conducted with key opinion leaders (KOLs), physicians and industry experts to validate the procedure volumes.

Scope

Reasons to buy

Key Topics Covered:

1 Table of Contents

1.1 List of Tables

1.2 List of Figures

2 Introduction

2.1 What Is This Report About?

2.2 Neurology Procedures Segmentation

2.3 Definitions of Procedures Covered in the Report

3 Neurology Procedures, Russia

3.1 Neurology Procedures, Russia, 2015-2025

3.2 Neurology Procedures, Russia, 2015-2025

4 Dura Substitute Procedures, Russia

4.1 Dura Substitute Procedures, Russia, 2015-2025

5 Hydrocephalus Shunting Procedures, Russia

5.1 Hydrocephalus Shunting Procedures, Russia, 2015-2025

5.1.1 Revision Hydrocephalus Shunts Procedures, Russia, 2015-2025

6 ICP Procedures, Russia

6.1 ICP Procedures, Russia, 2015-2025

7 Intracranial Stenting Procedures, Russia

7.1 Intracranial Stenting Procedures, Russia, 2015-2025

8 Minimally Invasive Neurosurgery Procedures, Russia

8.1 Minimally Invasive Neurosurgery Procedures, Russia, 2015-2025

8.1.1 Minimally Invasive Neurosurgical Devices Procedures, Russia, 2015-2025

9 Neuromodulation Procedures, Russia

9.1 Neuromodulation Procedures, Russia, 2015-2025

10 Neurovascular Accessory Procedures, Russia

10.1 Neurovascular Accessory Procedures, Russia, 2015-2025

11 Neurovascular Coiling Assist Procedures, Russia

11.1 Neurovascular Coiling Assist Procedures, Russia, 2015-2025

12 Neurovascular Embolization Procedures, Russia

12.1 Neurovascular Embolization Procedures, Russia, 2015-2025

12.1.1 Flow Diversion Stent Procedures, Russia, 2015-2025

13 Neurovascular Thrombectomy Procedures, Russia

13.1 Neurovascular Thrombectomy Procedures, Russia, 2015-2025

14 Appendix

For more information about this report visit https://www.researchandmarkets.com/r/7b7fs5

View source version on businesswire.com: https://www.businesswire.com/news/home/20200217005276/en/

Contacts

ResearchAndMarkets.comLaura Wood, Senior Press Managerpress@researchandmarkets.com For E.S.T Office Hours Call 1-917-300-0470For U.S./CAN Toll Free Call 1-800-526-8630For GMT Office Hours Call +353-1-416-8900

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Russia Neurology Procedures Outlook Over the Period, 2015-2025 - ResearchAndMarkets.com - Yahoo Finance

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