Polymer nanoparticle averts anti-cancer drug resistance

By Barry Copping

Posted 30 August 2012

Curcumin from turmeric features in novel drug formulation

In a double benefit from nanotechnology, researchers at the Johns Hopkins University Center of Cancer Nanotechnology Excellence (HCCNE) have created a polymer nanoparticle that overcomes the resistance of tumours to the common anticancer agent doxorubicin.

It also protects the heart against drug-triggered damage, a therapy-ending side effect that limits doxorubicins effectiveness. The nanoparticle incorporates both doxorubicin and curcumin, a major component of the bright yellow spice turmeric.

The work was led by Anirban Maitra. Recent studies had shown that high doses of curcumin could overcome the resistance to multiple anticancer agents that many, if not most, tumours develop over time. However curcumin is only poorly soluble in the bloodstream, so getting high enough levels of the agent to tumours was challenging.

Maitras approach to solving this problem was to use polymer nanoparticles to deliver curcumin to tumours. The teams latest paper describes how both in vitro and animal tests demonstrated that a dual curcumin/doxorubicin formulation showed striking anticancer activity in models of multiple myeloma, leukaemia, prostate cancer and ovarian cancer.

Perhaps equally important, the animals treated with the nanoparticle did not experience any cardiac toxicity or bone marrow suppression. This was the case even at cumulative doses that normally trigger cardiac toxicity by free doxorubicin or liposome-encapsulated doxorubicin. These were the first two nanoparticle drug formulations approved for use in treating cancer in humans; they are widely used in treating breast cancer. Further examination of the heart-protecting characteristics of the dual formulation showed that encapsulating doxorubicin in a polymer nanoparticle spared heart muscle cells from the oxidative stress normally triggered by doxorubicin.

The work is reported in the peer-reviewed journal Oncotarget.

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Polymer nanoparticle averts anti-cancer drug resistance

NanoMech Wins 2012 Innovator of the Year Award from Leading Nanotechnology Trade Organization

SPRINGDALE, Ark.--(BUSINESS WIRE)--

NanoMech, an international material science company and leader in nanotechnology innovation, is pleased to announce that the NanoBusiness Commercialization Association (NanoBCA) has selected it for the 2012 Top Emerging Nano Innovators Award.

We are very proud of this recognition, said Jim Phillips, NanoMech Chairman and CEO. The breakthrough technologies the NanoMech team has developed, such as nGlide, TuffTek, and TriboTuff, have led to this tremendous honor for our family of loyal employees and very supportive investors. NanoMech is focused on innovating by applying breakthrough novel science into "must-have" products bringing immediate and drastic improvement into existing major markets."

The NanoBCA (www.nanobca.org) is the industrys top trade organization dedicated to promoting the advancement and commercialization of nanotechnology while helping companies bring affordable, life-improving nanotech products to the market.

Mr. Vincent Caprio, the CEO of the NanoBusiness Commercialization Association said, "We are very proud to single NanoMech out of the vast field of up and coming emerging nanotechnology companies in America. NanoMech is a clear leader in converting massive brainpower and applied research to market-ready products that will disrupt huge companies overnight in the energy and manufacturing sectors, bringing immediate efficiency and performance improvements to these global industries! They are clearly a company to watch and at the top of our list."

Dr. Ajay P. Malshe, the CTO of NanoMech said, "In 2012 NanoMech commercialized two nano-engineered product platforms never achieved before. TriboTuff is a nano-inspired industrial lubricant which reduces friction (to near zero) and wear of mechanical parts by orders of magnitude allowing hundreds of percent enhancement in wear reduction in machines, vehicles, and components such as valves, gears and much more. These performance increases also produce incredible energy savings. Our second nanotechnology platform of products is TuffTek coated cutting tool inserts and wear parts made of carbides, metals and ceramics. As natural resources such as metals and ceramics are depleting nationally and globally, TuffTek radically transforms surfaces with nano engineered coating solutions, that increase the life of cutting tools and wear parts by as much as 1000% while enhancing their performance and sustainability."

About NanoMech:

NanoMech Inc., (www.NanoMech.com), was founded in 2002 and creates advanced engineering materials through patent and patent-pending nano-inspired and nano-manufactured product development. NanoMech is a pioneer in applying breakthrough nano-engineered innovations to robust areas of national interest including machining and manufacturing, lubrication and energy, and strategic military applications. NanoMech brings ideas from innovation to implementation, commercializing nanomanufactured products at record speed in the market. NanoMech is a member of President Obamas Materials Genome Initiative, a public / private collaboration with the aim of doubling the speed and reducing the cost of discovering, developing, and deploying new advanced materials. NanoMech is also a member of the U.S. Manufacturing Competitiveness Initiative (USMCI) and the U.S. Technology Leadership and Strategy Initiative, (www.Compete.org) both based in Washington, DC.

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NanoMech Wins 2012 Innovator of the Year Award from Leading Nanotechnology Trade Organization

Nanotechnology takes centre stage in food waste talks

With food sustainability rising up the political agenda, understanding and managing shelf-life will be critical for future quality and profitability of food products.

The development of novel technologies to help solve this has been identified by the EU as one of the main drivers going forward, especially in creating intelligent and smart packaging solutions which could, for example, incorporate sensors to monitor the condition of food.

The workshop is being hosted by the Nanotechnology Knowledge Transfer Network (NanoKTN) alongside partners Biosciences KTN and Leatherhead Food Research.

The technologies under discussion will include pulsed light, high pressure processing, modified atmosphere packaging and pulsed electric fields.

In particular, demonstrations around category label technology will show how this can be used to display ripeness levels, defrosting indication and the ingress of other contaminants.

NanoKTN theme manager Dr Barry Park said that with increasing pressures on the food industry, events like this will be "crucial" to engaging the entire supply chain.

"More and more we are hearing about the need for food to stay fresher for longer, whilst maintaining consistent characteristics in terms of texture, colour and taste and also whilst still being healthy, safe and value for money," he said.

High-tech breakthroughs such as nanotechnology are now paving the way forward for future packaging innovations as companies look to optimise material performance in terms of product preservation and environmental impact.

Maxine Perella

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Breakthrough in nanotechnology

Public release date: 29-Aug-2012 [ | E-mail | Share ]

Contact: Zenaida Kotala zenaida.kotala@ucf.edu 407-823-6120 University of Central Florida

A University of Central Florida assistant professor has developed a new material using nanotechnology, which could help keep pilots and sensitive equipment safe from destructive lasers.

UCF Assistant Professor Jayan Thomas, in collaboration with Carnegie Mellon University Associate Professor Rongchao Jin chronicle their work in the July issue of the journal Nano Letters. (http://dx.doi.org/10.1021/nl301988v)

Thomas is working with gold nanoparticles and studying their properties when they are shrunk into a small size regime called nanoclusters. Nanoparticles are already microscopic in size, and a nanometer is about 1/80000 of the thickness of a single strand of human hair. Nanoclusters are on the small end and nanocrystals are on the larger end of the nanoregime. Nano clusters are so small that the laws of physics that govern the world people touch and smell aren't often observed.

"Nanoclusters occupy the intriguing quantum size regime between atoms and nanocrystals, and the synthesis of ultra-small, atomically precise metal nanoclusters is a challenging task," Thomas said.

Thomas and his team found that nanoclusters developed by adding atoms in a sequential manner could provide interesting optical properties. It turns out that the gold nanoclusters exhibit qualities that may make them suitable for creating surfaces that would diffuse laser beams of high energy. They appear to be much more effective than its big sister, gold nanocrystal which is the (nano) material used by artists to make medieval church window paintings.

So why does it matter?

Think of commercial pilots or fighter pilots. They use sunglasses or helmet shields to protect their eyes from the sun's light. If the glasses or helmet shield could be coated with nanoclusters tested in Thomas' lab at UCF, the shield could potentially diffuse high-energy beams of light, such as laser. Highly sensitive instruments needed for navigation and other applications could also be protected in case of an enemy attack using high energy laser beams.

"These results give me great pleasure since the technique we used to study the optical properties of these atomically precise particle is one invented by UCF Professors Eric VanStryland and David Hagan many years ago," Thomas said. "But the progression we've made is very exciting."

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Breakthrough in nanotechnology

Nanotechnology: Armed resistance

Under attack: policemen stand guard outside the Monterrey Institute of Technology and Higher Education after a letter bomb exploded there in August 2011.

A. FRANCO/AP/PRESS ASSOCIATION IMAGES

The shoe-box-sized package was addressed to Armando Herrera Corral. It stated that he was the recipient of an award and it was covered in official-looking stamps. Herrera, a computer scientist at the Monterrey Institute of Technology and Higher Education in Mexico City, shook the box a number of times, and something solid jiggled inside. What could it be? He was excited and a little nervous so much so, that he walked down the hall to the office of a colleague, robotics researcher Alejandro Aceves Lpez, and asked Aceves to open it for him.

Aceves sat down at his desk to tear the box open. So when the 20-centimetre-long pipe bomb inside exploded, on 8 August 2011, Aceves took the full force in his chest. Metal pierced one of his lungs. He was in intensive care. He was really bad, says Herrera's brother Gerardo, a theoretical physicist at the nearby Centre for Research and Advanced Studies of the National Polytechnic Institute (Cinvestav). Armando Herrera Corral, who was standing nearby when the bomb went off, escaped with a burst eardrum and burns to his legs.

The next day, an eco-anarchist group calling itself Individuals Tending Towards Savagery (ITS) claimed responsibility for the bombing in a 5,500-word diatribe against nanotechnology that it published online. Police found a charred copy of a similar text in the detritus of the explosion. The bombers said that Herrera had been targeted for his role as director of the technology-transfer centre at the Monterrey Institute of Technology and Higher Education (commonly known as Monterrey Tec), one of the major universities that has staked everything on the development of nanotechnology. The text talked of the potential for the field to cause environmental nanocontamination, and concluded that technology and civilization as a whole should be held responsible for any environmental catastrophe. Chillingly, the bombers listed another five researchers at Monterrey Tec as presumptive targets, as well as a further six universities.

Reporter Leigh Phillips talks about anti-science violence in Mexico.

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The incident had precedent. The ITS had already claimed responsibility for bomb attacks in April and May 2011, both targeting Carlos Alberto Camacho Olgun, head of engineering and nanotechnology at the Polytechnic University of the Valley of Mexico in Tultitln. The first bomb wounded a security guard; the second was identified and disposed of before anyone could be hurt. Last December, the group struck again this time at the Polytechnic University of Pachuca, where a package containing gunpowder exploded in the hand of a teacher, causing minor burns (see 'A litany of letter bombs'). No other developing country has suffered a comparable string of anti-technology attacks.

One year on from the bombing at Monterrey Tec, the repercussions are still being felt. Armando Herrera Corral and Aceves will not speak to Nature about what happened. It's too sensitive, you understand? is all Aceves would say. Herrera has left his job as director of the university's technology park and is now head of postgraduate studies. Other Mexican universities with nanotechnology research programmes have evacuated campuses in response to bomb threats, and universities across the country have introduced stringent security measures. Some researchers are anxious for their own safety; some are furious about being targets. But all the researchers that Nature spoke to in Mexico are adamant that the attacks will not discourage them from their research or dissuade students from entering the field.

So far, there has been little explanation of where the vitriol is coming from. Why are radical environmental groups targeting nanotechnology? Is this field being confronted with the same sort of militant hostility that has dogged genetic-modification research and animal testing? And why Mexico?

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Nanotechnology: Armed resistance

Fifth edition of Bangalore Nano on December 6, 7

It is important to focus on nanotechnology field

The fifth edition of Bangalore Nano, the annual nanotechnology conference-cum-trade show organised by the Karnataka government, will be held on December 6 and 7.

C.N.R. Rao, scientific adviser to the Prime Minister, said that it was a matter of pride that his city, Bangalore, was at the forefront of leading and nurturing innovation in the field of nanotechnology. He spoke about his visit to Israel where he met a young researcher who wanted to use exhaled air and analyse molecules to detect cancer. Years later, Prof. Rao got to know that the researcher came up with a product called the nano nose that helps detect cancer. Such are the possibilities of nanotechnology, and this is why it is important to focus on this emerging field, he said.

Criticising the resistance among academia to collaborate on research work, Prof. Rao said that working together is imperative to move forward.

Nano, a game changer

Chief Secretary S.V. Ranganath said that Karnataka has taken an early lead in science and technology, and compared the nanotechnology scene now to what IT was two decades ago. Nano is going to be a game changer, and it presents a unique challenge as it applies across disciplines. He said that Karnataka has 396 research and development organisations and over 2,100 IT companies, and that over 40 per cent of software exports come from here.

The two-day event includes several plenary sessions on healthcare and medicine, aerospace and defence, electronics, food and agriculture, energy and environment, water management solutions and advanced materials.

The event organisers claim that over 100 leading international and domestic companies are slated to participate. A poster presentation session will display at least 120 posters, and 450 graduate level students will attend the event. As part of the conference, the Research Industry Collaboration Hub will be organised.

The pre-event schedule includes a pre-conference tutorial session on December 5 for delegates.

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Fifth edition of Bangalore Nano on December 6, 7

Basque region backs nanotechnology research

Nanotechnology for food and other industries is receiving strong support in the Basque region of Spain, with cash being channelled to researchers through the EU Framework 7 research funding programme.

Thats according to Dr Yolanda de Miguel, research and development project manager working on nanostructured and eco-efficient materialsat Tecnalia Research & Innovations construction unit, sustainable development divisin.

The group is exploring a wide variety of pan industry studies, including nanotechnology, which de Miguel told FoodNavigator has broad applications for the food industry.

Some scientists are looking at ways of using nanotechnology to block cholesterol from entering the bloodstream. Others are looking at applying it to the area of food safety, using antimicrobial coatings for work surfaces.

'Bettering packaging'

Others are exploring its potential for use in packaging materials to extendproductshelf life, for example.Its being explored in bettering packagingby increasing its oxygen-barrier properties,"saidDr. de Miguel.

Major food brands such as Nestl, Unilever, Kraft and Heinz were known to be investigating nanotechnology and the Basque research would help support such endeavours, she said.

One of her major areas of focusat present is developingnano-coatingsfor different types ofsurfaces,which would in a sense make them self-cleaning. The coatings use nanoparticles of titanium dioxide, which at that size become translucent and react with oxygenand water moleculesin air to release high energy radicals, which destroy the cell wall of harmful microbes.These hydroxyl radicalswill alsodegradeorganic material on the surface, which meansthat the surfacestays clean for longer,said de Miguel.

Hydrophilic

Coating nanoparticlesof titanium dioxideonto a given surface can also make it hydrophilic, whichmeans water canbe used more easily to washit,plusthe surface does not show water droplets remaining on it as the droplets run easily off them.

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Precise Patterning of Nanocrystal Films Achieved

Category: Science & Technology Posted: August 27, 2012 10:57AM Author: Guest_Jim_*

Nanotechnology takes many forms, as it can offer special electrical and optical properties, just based on the patterns and materials used. Precisely making these patterns, however, is quite difficult in part because the patterned films involved often have defects. These defects also make measuring the properties of the nanotechnology device difficult to accurately measure. Now researchers at MIT have discovered a way to create these patterns in the film without any defects.

It turns out what the researchers needed was to coat the silicon dioxide substrate with a polymer, which the nanocrystals and films could attach to. Essentially the polymer provided a foundation the nanocrystals would stay on, whereas the silicon dioxide would not always hold them in place, which caused the defects. Luckily testing to make of these structures sped up greatly once they started working with devices that operate in the visible part of the spectrum. Instead of having to look at it with a microscope, they could just see if it was emitting light correctly.

This discovery could impact not only optical systems but electrical as well. While the nanostructures can be tuned to respond to any frequency, the researchers found that the electrical conductivity of their defect free films was actually 180 times greater than the imperfect films made by more conventional means.

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Nanofibres 'may pose health risk'

23 August 2012 Last updated at 22:27 ET

Inhaling tiny fibres made by the nanotechnology industry could cause similar health problems to asbestos, say researchers.

Some are similar in shape to asbestos fibres, which have caused lung cancers such as mesothelioma.

Research on mice, published in Toxicology Sciences, suggests the longer nanofibres are more dangerous.

Human and mouse lungs are different, but the researchers hope the study will help to design safer nanofibres.

Nanofibres are in a range of goods, from airplane wings to tennis rackets.

Ken Donaldson, professor of respiratory toxicology at the University of Edinburgh, said: "Concern has been expressed that new kinds of nanofibres being made by nanotechnology industries might pose a risk because they have a similar shape to asbestos."

Silver nanofibres of varying lengths were injected into the lungs of mice.

Those larger than five micrometres, or five-thousandths of a millimetre, tended to become lodged in the lungs and cause inflammation. The smaller ones were cleared from the lungs.

Prof Donaldson said: "We knew that long fibres, compared with shorter fibres, could cause tumours, but until now we did not know the cut-off length at which this happened.

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Industrial Nanotech, Inc. Announces Another Skylight Project

NAPLES, Fla.--(BUSINESS WIRE)--

Industrial Nanotech, Inc. (Pink Sheets:INTK), an emerging global leader in nanotechnology based energy saving solutions, today announced that the Companys patented Nansulate(R) translucent thermal insulation and protective coating was specified into a recently awarded renovation project by the City of Miami. The nanotechnology based coating, which insulates while allowing through visible light and providing UV resistance, will be used for skylight insulation in the Caribbean Marketplace Renovation Project being undertaken by the City of Miami.

We look forward to having our technology be a part of the renovation of an important piece of South Florida history, stated Francesca Crolley, V.P. Business Development for Industrial Nanotech, Inc. Our coating technology is very well suited for use as skylight insulation because it provides an effective way to reduce heat transfer through glass or plexiglass, while also allowing transmission of approximately 92% of visible light, as tested on pane glass, and providing important UV resistance. Our coatings have been used in skylight applications at the Tampa Port Authority, The Vernon Bank in Louisiana, and at the Frost Art Museum at Florida International University, just to name a few. Skylights are often used in architecture to allow in natural daylight, which reduces the need for interior lighting. Unfortunately, without the protective advantage that Nansulate(R) offers, they can act as a problem area for heat loss and gain, therefore increasing cooling and heating costs. Another issue is glare and harmful UV rays streaming through the glass, which are all problems that our coating technology solves. Nansulate(R) translucent coatings are easy to apply, highly resistant to UV rays, and diffuse light... causing less glare. This combination of protective benefits along with energy savings make our technology a perfect option for insulation of skylights."

The return of the Caribbean Marketplace marks renewed efforts to boost tourism for Miami while preserving Little Haiti's history. The only building in South Florida to win the American Institute of Architects' national honor award, the structure was designed by Haitian-American Charles Harrison Pawley and inspired by the famed Iron Market in Port-au-Prince.

About Nansulate(R)

Nansulate(R) is the Company's patented product line of award winning, specialty coatings containing a nanotechnology based material and which are well-documented to provide the combined performance qualities of thermal insulation, corrosion prevention, resistance to mold growth, chemical resistance and lead encapsulation in an environmentally safe, water-based, coating formulation. The Nansulate(R) Product Line includes industrial, residential, agricultural and solar thermal insulation coatings. Additional information about the Company and its products can be found at their websites, (www.inanotk.com) and (www.nansulate.com). Blog: http://www.nansulate.com/nanoblog, Twitter: http://www.twitter.com/NanoPioneer, Facebook: http://www.facebook.com/Nansulate.

About Industrial Nanotech Inc.

Industrial Nanotech Inc. is a global nanoscience solutions and research leader and member of the U.S. Green Building Council. The Company develops and commercializes new and innovative applications for sustainable nanotechnology which are sold worldwide.

Safe Harbor Statement

Safe Harbor Statement under the Private Securities Litigation Reform Act of 1995: This release includes forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995 that involve risks and uncertainties including, but not limited to, the impact of competitive products, the ability to meet customer demand, the ability to manage growth, acquisitions of technology, equipment, or human resources, the effect of economic and business conditions, and the ability to attract and retain skilled personnel. The Company is not obligated to revise or update any forward-looking statements in order to reflect events or circumstances that may arise after the date of this release.

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ANSI Nanotechnology Standards Panel Meeting Announced for October in Washington, DC

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ANSI Nanotechnology Standards Panel Meeting Announced for October in Washington, DC New York August 27, 2012

The American National Standards Institute's Nanotechnology Standards Panel (ANSI-NSP) will hold a meeting on October 30, 2012, in Washington, DC. Formed in 2004, ANSI's NSP serves as the cross-sector coordinating body for the facilitation of standards development in the area of nanotechnology.

Nanotechnology, linked to nanoscale science and engineering, involves the understanding and control of matter at the nanoscale, (approximately 1-to-100 nanometers), where unique phenomena allow for innovation and novel technological applications. The ANSI-NSP works to provide a forum for standards developing organizations (SDOs), government entities, academia, and industry to identify needs and establish recommendations for the creation or updating of standards related to nanotechnology and nanomaterials. In addition, the ANSI-NSP solicits participation from nanotechnology-related groups that have not traditionally been involved in the voluntary consensus standards system, while also promoting cross-sector collaborative efforts.

ANSI president and CEO S. Joe Bhatia said, Nanotechnology is a growing and vital field that has the potential to change current industries and pave the way to new ones. The ANSI-NSP looks forward to building on its record as a coordinator and facilitator of responsive nanotechnology standardization activities that keep pace with the fields advancement.

The ANSI-NSP encourages SDOs involved in nanotechnology standardization, representatives from companies working with nanomaterials or developing nanotechnology-based products and solutions, government agencies, consumer groups, and academics, to take part in the October meeting, which is free to attend. The meeting will include updates from SDOs developing nanotechnology standards and from industry representatives regarding their current needs in this area.

The meeting will take place on October 30, 2012, from 12 p.m. to 5 p.m., at the offices of the law firm Sidley Austin LLP (1501 K Street NW, Washington, DC). Individuals planning to attend the October NSP meeting may register online here. For more information, visit the event Web page or contact Heather Benko (hbenko@ansi.org), ANSI senior manager, nanotechnology standardization activities.

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Lessons learned in creating biomedical nanoparticles for human use

Over the past six years, the National Cancer Institutes (NCI) Nanotechnology Characterization Laboratory (NCL), a key component of the NCIs Alliance for Nanotechnology in Cancer, has characterized more than 250 different nanomaterials developed by over 75 research groups. This extensive experience has given NCL staff a unique perspective on how to design safe and biocompatible nanomaterials for human use. In a paper published in the journal Integrative Biology, the NCL team shared some of the lessons they have learned.

The NCL performs and standardizes the pre-clinical characterization of nanomaterials intended for cancer therapeutics and diagnostics developed by researchers from academia, government, and industry. The Lab serves as a national resource and knowledge base for cancer researchers, and facilitates the development and translation of nanoscale particles and devices for clinical applications. Scott McNeil, the NCLs director, and seven colleagues compiled the common pitfalls that nonmaterial developers encounter on their path from basic research, to products that will be tested as agents for imaging or delivering drugs to tumors in humans.

One important lesson for nanomaterial developers, who tend to be academic researchers with little experience developing products intended for clinical use, is that they need to focus more on ensuring that the materials they develop for testing in animals, and eventually humans, are sterile. A recent review of 75 samples arriving at the NCL for testing found that more than one-third showed evidence of bacterial contamination.

Another important lesson was that commercially available materials, whether they are nanomaterials or chemicals used to make nanomaterials, are not always what they appear to be. In some cases, these raw materials are contaminated with bacterial toxins, in other cases the products do not meet the specifications advertised by the manufacturers. Dr. McNeil and his colleagues note that it is in the researchers best interest to always characterize materials before proceeding with synthesis and more expensive functionalization and biological testing.

NCL staff also found that investigators need to do a better job purifying their nanomaterials of residue remaining from the processes they use to manufacture their nanoparticles and other formulations. In some cases, nanomaterials that appeared to be toxic were in fact biocompatible. Instead, it was production impurities that were causing toxicity issues. Additionally, NCL studies have shown that nanomaterial toxicity can often be eliminated by choosing slightly different starting materials that are incorporated into the final product but that do not play a role as an imaging agent or anticancer drug.

The last two lessons have to do with the importance of developing the right methods for assessing a nanomaterials stability in the body and the rate at which it releases its cargo at the intended target, the tumor. NCL team leaders recommend that nanomaterial developers employ multiple assays before beginning animal studies to determine these characteristics of their nanomaterials because single assays can often paint an incomplete picture that can lead to wasted time and money.

The work that produced these findings is described in more detail in a paper titled Common pitfalls in nanotechnology: lessons from the NCIs Nanotechnology Characterization Laboratory. An abstract of this paper is available at the journals website.

More information: Abstract: DOI: 10.1039/C2IB20117H

Journal reference: Integrative Biology

Provided by National Cancer Institute

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‘Nanojackets’ for treating breast cancer could be game changer for cancer care

A novel nanotechnology drug delivery system under development to infiltrate breast cancer tumors could pave the way for treating other diseases.

Penn State College of Medicine received a $1 million grant from a state research fund set up with money from its tobacco settlement to assess the drug treatments commercialization potential.

The principal investigator for the nanotechnology delivery system is Mark Kester, a professor of pharmacology and director of the Penn State Center for NanoMedicine and Materials. He has been working for the past five to six years with Jim Adair of Penn States department of material sciences and engineering, and Keystone Nano, a nanotechnology company spun out of Penn State University led by Jeff Davidson, the founder of the Biotechnology Institute and Pennsylvania Bio industry association.

The next generation of cancer-fighting drugs specifically target cancer proteins rather than attack cancer and noncancer cells indiscriminately. Although companies have recognized the ability of small interfering RNA as a small molecule that can be directed to interfere with the production of cancer cells, the toxicity of siRNA has proved a challenge in its use. Biotechnology companies and institutions have been studying ways to use different nanotechnology particles to house the toxic molecule.

In an interview with MedCity News, Kester explained that the team has developed nontoxic nanojackets that use calcium phosphocillate nanoparticles, material that makes up teeth and bones, to deliver the toxic siRNA safely to the gene mutation. In this case, the one that causes overexpression of an oncogenic protein in breast cancer patients.

Getting to this stage has taken five to six years. Kester estimates it will take another one-and-a-half years to get to the point where it will have enough data to submit an IND application. During that time it will work with contract research organizations across Pennsylvania to conduct preclinical trials using the nanojackets.

Even if the companys IND application is approved, it will take another five to eight years to get the technology to the point where it can be submitted for FDA approval.

A cursory search on Clinicaltrials.gov revealed that 10 clinical studies are using siRNA to combat diseases in clinical trials. The one that is using them to fight breast cancer uses fat cells to house the toxic molecule.

If successful, the siRNA molecule could theoretically be delivered to any protein mutation and destroy it, a development that would revolutionize not only cancer treatment but one that could lead to treating Alzheimers and Parkinsons disease and other unmet needs.

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‘Nanojackets’ for treating breast cancer could be game changer for cancer care

Officials continue to push for chip fab manufacturer

There still is no decision from the Army Corps of Engineers about key preparations for land being marketed to nanotechnology companies as a chip fabrication site.

But local economic development officials say the process has become a race against time, as the multi-billion dollar industry ramps up for a shift in the way chips are produced.

We think the next site selection will be in 2013 and 2014, said Mohawk Valley EDGE economic development agency President Steve DiMeo. The major players and some of the support industry (are) talking about timelines for actually building and having output from a 450 mm plant.

DiMeo was referring to the new generation of nanotechnology chips, which will be made in a new 450 mm format.

Currently, most of the chips, which can be found in everything from cell phones to medical devices, are made many at a time on 300 mm wafers. Companies now want to make them on 450 mm wafers, so more of the tiny chips can be manufactured at once.

In September 2011, New York Gov. Andrew Cuomo announced $4.4 billion in private investment in nanotechnology initiatives in New York state.

That was in addition to the 2009 announcement that $45 million in state funds would be spent at SUNYIT to create a state of the art nanotechnology research and development compound.

Those investments are hoped to up the appeal of the Marcy site, which has been on the market for more than a decade. So far, about $16 million has been spent to prepare the site. A total of $39 million in work is planned.

Long time coming

The tussle with the Army Corps has been going on almost as long as the SUNYIT-owned site has been marketed to the nanotechnology industry.

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How Nanotechnology Is Changing How You Eat And Taste

Israels Shemen Industries introduced a product it calls Canola Active Oil, which it claims can reduce the bodys cholesterol intake by upwards of 14%. How does it do this? Using a technology it calls nano-sized self-assembled liquid structures (NSSL), which help to keep cholesterol from jumping from the digestive tract to the bloodstream. NSSLs, or nanodrops, as the company calls them, are added to the oil to create a water-soluble bubble of sorts that allows the healthier phytosterols that are abundant in plants and their oils to outcompete cholesterols to move into the bloodstream, thereby fighting against the causes of heart disease.

SlimShake-Chocolate, once marketed by Texas-based RBC Life Sciences (the product seems to have been discontinued since its nowhere to be found on the manufacturers site), featured an innovation called called Nanoclusters. These clusters were tiny structures that are 100,000th the size of a grain of sand. The company coated them with cocoa to form CocoaClusters, which, because of their greater surface area relative to their mass, delivered more chocolate taste, eliminating the need for excess sugar that makes these drinks bad for you.

The gloriously named Shenzhen Become Industry & Trade Co. Ltd., has developed a technique called ball-milling, which it uses to pulverize plants into particles that are fewer than 100 nanometers in diameter. The NanoTea made from this process allows for the release of 10 times as much selenium, a naturally occurring element that has antioxidative effects in the body.

A technology developed at the U.K.s University of Nottingham is another example of a nanofood exploiting the surface-area-to-mass ratio of a nanoparticle to deliver more flavor with less product. In the case of SODA-LO, the product is salt. By creating smaller salt crystals, SODA-LO, according to a press release from the company, enables added salt levels to be reduced by up to 30% in foods such as bread, pizza bases, pastry, savory pie fillings, cheese, and baked snacks.

First developed in the mid-1990s, FANTESK is a simple technology: Its essentially an oil trapped in a starch. That encapsulated oil, however, is distributed evenly in the starch giving it a uniform taste and allowing for the creation of many low fat items containing FANTESK, from soft-serve to cheddar cheese. Recently, scientists at the Agricultural Research Services National Center for Agricultural Utilization Research in Peoria, Illinois, have put a FANTESK mixture of cooking oil with no trans-fats and wheat flour into cake mixes and frostings. The result: Delicious buttercream with only half the fat.

Food isnt just the end product where these nano-developments end up. In some cases, food itself enables the technology. In 2005, two Dutch researchers revealed a method for creating a nanotube out of a protein found in milk called alpha-lactalbumin. The proteins ability to be coaxed into forming such a structure means it could well serve as a vehicle for encapsulated molecules, such as for example vitamins and enzymes, the researchers wrote in Trends in Food Science and Technology, which would allow scientists to easily fortify your breakfast cereal with more essential nutrients.

Scientists at Norwichs Institute of Food Research in the U.K. are working on a method for developing low-fat food that tastes good. They are specifically targeting emulsions, such as mayonnaise (which are simply oil suspended in proteins). Low-fat mayo is made by taking out half the yummy fat and replacing it with water. The researchers are hoping that by creating nano-droplets of water, they can suspend them in the oil, so an eater is greeted with that signature mayo taste with the water hidden within, instead of the current version, which tastes like watery mayo.

Writing in the journal Appetite, a group of researchers at the Swiss Federal Institute of Technology Zurich discussed the risks associated with applying nanotechnology to the food industry. Among the topics mentioned in the report were so-called individually modifiable foods, which would employ various encapsulated ingredients so that heating an item in a microwave in a certain way could alter properties like its color or taste. Sure enough, there have been reports, such as this possibly tounge-in-cheek one in The Guardians Observer magazine, about programmable wine where one day a prospective buyer could decide at the absolute last minute (relatively speaking) whether he or she preferred white or red. Well believe this one when we see it.

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How Nanotechnology Is Changing How You Eat And Taste

Removing hazardous substances from the air

Volatile organic compounds (VOCs) are carbon-based compounds, many of which are hazardous to humans' health. EU-funded researchers coordinated efforts to apply nanotechnology to the capture and sequestration of these compounds.

VOCs evaporate into the air at room temperature. The evaporation process produces tiny air-borne molecules that may be unsafe to those who inhale them, come into contact with them via skin, or drink them in contaminated water supplies.

While the use of VOCs has been restricted in recent years, there are still thousands of products present in everyday life that contain VOCs. Removal of VOCs from waste air streams, whether at factories that use VOCs or at wastewater treatment plants that remove VOCs from wastewater, is commonly accomplished with separation membranes.

The application of nanotechnology (technology on the scale of atoms or molecules) to membrane filtration of VOCs in waste air streams may greatly enhance functionality.

Nanoparticles have the unique feature of having very high surface areas compared to their volumes. This surface area is extremely useful as a work surface for chemical reactions and absorption of other molecules.

However, integration of nanotechnology with membrane separation technology for more efficient and greener removal of VOCs from waste air streams is an emerging, developing field.

In order to coordinate efforts in research with those in industry and in policymaking bodies, European researchers initiated the ANVOC project.

The main goal of the project was to organise a symposium bringing together stakeholders from all areas to disseminate knowledge to end users and to facilitate cooperation among research and development (R&D) bodies.

ANVOC scientists met all goals, bringing together international experts in nanotechnology, membrane technology and air pollution control.

The symposium presented R&D results, identified the types of membranes used in recovery of VOCs, and demonstrated the use of membranes in gas separation. In addition, valuable possibilities for future research collaboration were identified.

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Removing hazardous substances from the air

Nanotechnlogy delivery system for breast cancer could be gamechanger for treating diseases

A novel nanotechnology drug delivery system under development to infiltrate breast cancer tumors could pave the way for treating other diseases.

Penn State College of Medicine received a $1 million grant from a state research fund set up with money from its tobacco settlement to assess the drug treatments commercialization potential.

The principal investigator for the nanotechnology delivery system is Mark Kester, a professor of pharmacology and director of the Penn State Center for NanoMedicine and Materials. He has been working for the past five to six years with Jim Adair with Penn States department of material sciences and engineering and Keystone Nano, a nanotechnology company spun out of Penn State University led by Jeff Davidson, the founder of the Biotechnology Institute and Pennsylvania Bio industry association.

The next generation of cancer fighting drugs, instead of going after cancer and non-cancer cells indiscriminately, specifically target cancer proteins. Although companies have recognized the ability of small interfering RNA as a small molecule that can be directed to interfere with the production of cancer cells, the toxicity of siRNA has proved a challenge in its use. Biotechnology companies and institutions have been studying ways to use different nanotechnology particles to house the toxic molecule.

In an interview with MedCity News, Kester explained that the team has developed non-toxic nanojackets using calcium phosphocillate nanoparticles, material that makes up teeth and bones, to deliver the toxic siRNA safely to the gene mutation, in this case the one that causes overexpression of an oncogenic protein in breast cancer patients.

Getting to this stage has taken five to six years. Kester estimates it will take another 1.5 years to get to the point where it will have enough data to submit an IND application. During that time it will work with contract research organizations across Pennsylvania to conduct preclinical trials using the nanojackets.

Even if the companys IND application is approved, it will take another five to eight years to get the technology to the point where it can be submitted for FDA approval.

A cursory search on Clinicaltrials.gov revealed that 10 clinical studies are using siRNA to combat diseases in clinical trials. The one that is using them to fight breast cancer uses fat cells to house the toxic molecule.

If successful, the siRNA molecule could theoretically be delivered to any protein mutation and destroy it, a development that would revolutionize not only cancer treatment but one that could lead to treating Alzheimers and Parkinsons disease and other unmet needs.

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Nanotechnlogy delivery system for breast cancer could be gamechanger for treating diseases

Brewer Science to Exhibit Technologies of the Future for America's Defense at Nanotechnology …

Brewer Science, a global leader in developing and manufacturing specialty materials, integrated processes, and laboratory-scale wafer processing equipment, is exhibiting at the 10th Annual NanoTechnology for Defense (NT4D) Conference, 6-9 August 2012, at the Red Rock Resort in Summerlin, Nevada.

Initiated a decade ago by the Air Force Research Laboratory, the Army Research Laboratory, the Office of Naval Research, the Defense Threat Reduction Agency, and the Defense Advanced Research Projects Agency, the NT4D Conference remains the premier event addressing emerging and nano-scale technologies for defense.

To highlight its advances in carbon nanotube technology to produce flexible electronics, Brewer Science will present "Design, prototying, and characterization of combustible passive radio-frequency identification (RFID) sensors on flexible substrates" during the conference poster session in the Red Rock Ballroom.

Visit Brewer Science at Booth No. 313 to learn about the advanced materials we offer for applications in U.S. Government energy and defense sectors.

Visit http://www.usasymposium.com/nano/exhibitors.htm for more information about the NT4D Conference.

About Brewer Science Brewer Science is a global technology leader in developing and manufacturing specialty materials, integrated processes, and laboratory-scale wafer processing equipment for applications in semiconductors, compound semiconductors, advanced packaging/3-D integrated circuits, MEMS, sensors, displays, LEDs, and printed electronics. The company continuously introduces high-technology solutions that enable reliable fabrication of cutting-edge, high-performance integrated microdevices used in the most advanced and elegant electronics such as tablet computers, smart phones, digital cameras, flat-panel monitors and TVs, and LED lighting. Since 1981, when its ARC material technology revolutionized lithography processes, Brewer Science has expanded its spectrum of technology to include products currently used in advanced lithography, chemical and mechanical device protection, thin layer handling, and 3-D integration, as well as products based on carbon nanotubes and nanotechnology. For more information on Brewer Science, please visit http://www.brewerscience.com

Brewer Science was recently named one of the top places to work by Missouri's largest daily newspaper, the St. Louis Post-Dispatch.

For additional information, contact: Patti Shaw, Marketing Communications Manager +1 573 364-0444, ext. 1183 pshaw@brewerscience.com

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Brewer Science to Exhibit Technologies of the Future for America's Defense at Nanotechnology ...

Nanotechnology Comes to TedTalks, with Mixed Results

For all the TEDTalks that there have been, few have adequately addressed the topic of nanotechnology, with the possible exception of Bill Joys ironic path from nanotechnology doomsayer to cheerleader.

That is why when I saw that venture capitalist and Nanoholdings CEOJustin Hall-Tippinghad been given a forum to discuss nanotechnology for the illustrious TedTalks last year, I had to give a listen (see video below).

Hall-Tipping did not disappoint. As you will see in the video, he provides all the gee-whiz nanotech applications one could hope for and throws in some emotion to pull at our heartstrings.

Hall-Tipping highlights three technologies in the video that, as he explains, exhibit exquisite control over the electron and could change our current energy paradigmwhich, according to his calculations, is doomed to ultimate failure. Two of the technologies come from research originated at the University of Florida; the third comes from the University of Texas at Dallas.

Hall-Tipping says that one of the technologies developed at the University of Florida will result in a world that doesnt need artificial light to illuminate our nights. In this case, I believe he is referring to the work of Prof. Franky So, developer of lightweight night-vision technologies. Thats great, but if Hall-Tipping really expects that nearly ubiquitous night-vision capabilities are going to spell the end for artificial light, I think he may have overstated his point.

The other University of Florida technology that Hall-Tipping highlights uses carbon nanotubes embedded in transparent polymer films to absorb the suns energy and release it indoors during the winter. And as Hall-Tipping describes it, the same film will flip it back in the summer, preventing solar energy from heating living spaces when you want to keep things cool. This application seems to be built around the work of John Reynolds and Andrew Rinzler.I suppose this work could be adapted to collect solar power and reflect away sunlight, but I would like to see some figures on energy conversion efficiency before I start disconnecting myself from the grid.

In the final technology, from the University of Texas at Dallas, nanomaterials (of the carbon nanotube variety,we assume) enable a device that, according to Hall-Tipping, can park an electron on the outside, hold it until it's needed, and then to release it and pass it off. The machine that accomplishes this electron parking, dubbed eBox, has apparently been around since 2009. A prototype has been running for over a yearwithout, it seems, any effort to commercialize it.

Later in the video, Hall-Tipping makes the cogent point that water shortages are already becoming acute around the world and that energy-intensive desalination is a problematic solution based our current energy paradigm. But removing the grid, or depending on solar power to change the dynamics, seems to be missing the point of a lot of nanotech research related to desalination. I suppose Hall-Tippings company is not backing those horses.

Finally, Hall-Tipping makes his concerns about water shortages personal when he reveals a photograph that he has carried with him for the last 18 years; in it, a young girl in the Sudan is dying of thirst. A truly heart-wrenching image, and as Hall-Tipping says, one that should never happen. But maybe that girl would have been better served by rather simple nanotech-based solutions for providing clean drinking water instead of reinventing the electrical grid.

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Nanotechnology Comes to TedTalks, with Mixed Results

Hy-Power Nano Inc. names Dr. Hadi Mahabadi as Chief Operating Officer

Former Xerox executive pioneered nanotechnology innovation and commercialization

BRAMPTON, ON, Aug. 9, 2012 /CNW/ - Hy-Power Nano Inc. has named Dr. Hadi Mahabadi as Chief Operating Officer after he became intrigued with the nanotechnology commercialization work taking place at the company.

"I see tremendous potential in the technology under development here, building made-in-Canada solutions with nanotechnology that could address customer needs around the world," says Dr. Mahabadi. "It's exciting to be able to utilize my expertise and contribute to the advancement of this important technology through a small, nimble company with great future potential."

Dr. Mahabadi, an innovation and commercialization leader, recently received an Order of Canada in June 2012 for his internationally recognized innovations in the field of polymer science and his commitment to promoting scientific development in Canada.

Previously, Dr. Mahabadi was Vice President and Director of the Xerox Research Centre of Canada, where he spearheaded many innovations and commercialized technologies. His expertise complements Hy-Power Nano's focus to combine proven ingenuity in the coatings sector, where its parent company operates, with nano-enabled innovation to bring exceptional products to market.

"Dr. Hadi Mahabadi offered tremendous insights when he joined our board in February 2012 and also served as a consultant," says Joseph Grzyb, CEO of Hy-Power Nano Inc. "We quickly realized he could play a more active role in the company by becoming COO. He's a great addition to the Hy-Power Nano team."

Dr. Mahabadi spent 30 years with Xerox, rising to the company's top Canadian research position. He retired from Xerox in Sept 2011 with more than 100 published scientific papers and over 200 US/international patents to his name; having received the Robert F. Reed Technology Medal (the Printing Industries of America's highest honour), two Xerox President Awards (the corporation's highest honour for individual achievement) and the University of Waterloo's Engineering Alumni's Achievement Medal. He is a Fellow of the Chemical Institute of Canada, a Fellow of the International Union of Pure and Applied Chemistry, and a Fellow of the Canadian Academy of Engineering.

Dr. Mahabadi also is President of CanWin Consulting Inc, which provides a range of services for innovation to start-up and other small and medium enterprises, such as Hy-Power Nano, in Canada.

About Hy-Power Nano Inc.

Hy-Power Nano Inc. (www.hy-powernano.com) of Brampton, ON, is a subsidiary of Hy-Power Coatings Limited, Southern Ontario's premier coatings service provider with a 45-year track record of innovation and application of industrial coatings. Hy-Power Nano is developing "next generation" nanocoating products that can deliver exceptional solar blocking and thermal insulation benefits. Hy-Power has attracted the interest of a number of commercial partners seeking the use of nano-enabled coatings and paints to enhance the energy efficiency of their products and the growing demand for high quality nano oxides used as transparent conductors to enable touch screen functionality.

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Hy-Power Nano Inc. names Dr. Hadi Mahabadi as Chief Operating Officer