jo lab – Cardiovascular Mechanobiology and Nanomedicine

Posted on November 27, 2018 by Dook Domini

Our lab studies the mechanisms by which blood flow regulates endothelial biology and dysfunction, which leads to atherosclerosis and aortic valve calcification. In addition to in vitro (a cone-and-plate bioreactor) systems, the lab also developed an in vivomodel (a mouse partial carotid ligation model) in conjunction with OMICs approaches to understand how disturbed flow vs. stable flow differently regulate vascular and valve endothelial biology and pathobiology at the genome-, epigenome-, and metabolome-wide level.With these methods, we have been able to carry out several OMICs studies that have allowed us to identify mechanosensitive mRNAs, microRNAs, epigenetic DNA methylome, metabolites, and long non-coding RNAs (on-going work). These genome-, epigenome- and metabolome-wide OMICs studies have guided us not only to identify mechanosensitive genes, metabolites and epigenetic changes, but to demonstrate the critical role that some of these flow-sensitive molecular transducers play a role in controlling endothelial biology, atherosclerosis and aortic valve disease

Postdoctoral Fellow in Mechanobiology and Disease at Emory

A postdoctoral position is available immediately to study the mechanisms by which mechano-sensitive genes and epigenetics regulate vascular biology, atherosclerosis and aortic valve disease, and to develop gene-based therapies and targeted delivery methods in Coulter Department of Biomedical Engineering at Emory University in Atlanta, Georgia, USA. We are looking for a motivated and talented biomedical scientist or engineer with PhD or MD in related fields and with strong publication record. Please apply here: https://faculty-emory.icims.com/jobs/18016/job, and also send your CV by e-mail to Professor Jo. Applications will be reviewed on a rolling basis until filled but by June 10, 2018.

See the article here:

jo lab - Cardiovascular Mechanobiology and Nanomedicine

Nanomedicine Conferences | Nanotechnology Events …

Posted on September 19, 2018 by Dook Domini

About Conference

ME Conferences invites all the participants from all over the world to attendNanomedicine and Nanotechnology in Health CareDuring 17-19 September, 2018 at Abu Dhabi, UAE. This includes prompt keynote presentations, Oral talks, Poster presentations and Exhibitions. And it provides an opportunity to learn about the complexity of the Diseases, discuss interventional procedures, look at new and advances in Nanotechnology and their efficiency and efficacy in diagnosing and treating various diseases and also in Healthcare treatments.

ME Conferences organizes 1000+ Global Events Every Year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open access journals which contains over 1,00,000 eminent personalities, reputed scientists as editorial board and organizing committee members. ME Conferences journals have over 5 million readers and the fame and success of the same can be attributed to the strong editorial board which contains over 30000 eminent personalities and the rapid, quality and quick review processing.ME Conferences make the perfect platform for global networking as it brings together renowned speakers and scientists across the globe to a most exciting and memorable scientific event filled with much enlightening interactive sessions, international workshops, world class international exhibitions and poster presentations.

Why to attend?

This Conference Nanomedicinemeet 2018 will focus on Healthcare and Medicine. World-renowned speakers, the most recent techniques, tactics, and the newest updates in fields Nanotechnology and Engineering, Medical Nanotechnology, Tissue Engineering are hallmarks of this conference. Nanomedicinemeet-2018 is an exciting opportunity to showcase the modern technology, the new products of your company, and/or the service your industry may offer to a broad international audience. It covers a lot of topics and it will be a nice platform to showcase their recent researches on Nanotechnology, MaterialScienceand other interesting topics.

Target Audience:

The termNano medicineencompasses a broad range of technologies and materials. Types of nanomaterials that have been investigated for use as drugs,, drug carriersor other Nonmedical agents. There has been steep growth in development of devices that integrate nanomaterials or other nanotechnology. Thenanotechnology-based medical devices market is categorized into three major segments, namely, therapeutic applications, diagnostics applications, and research applications. Rising incidence of lifestyle and age-related disorders (such as cardiovascular and hearing disorders) has contributed significantly to the growth of the nanotechnology-based active implantable devices market. Nanotechnology, or systems/device manufacture at the molecular level, is a multidisciplinary scientific field undergoing explosive development. The genesis of nanotechnology can be traced to the promise of revolutionary advances across medicine, communications and genomics. On the surface, miniaturization provides cost effective and more rapidlyfunctioningbiological components. Less obvious though is the fact that Nanometer sized objects also possess remarkableself-ordering and assemblybehaviors under the control of forces quite different from macro objects.

Advances in technology have increased our ability to manipulate the world around us . Nanotechnology is rapidly emerging within the realm of medicine. Nanomedicine is the process of diagnosing, treating, and preventing disease andtraumatic injury, of relieving pain, and of preserving and improving human health, using molecular tools and molecular knowledge of the human body. An exciting and promising area of Nano technological development is the building of Nanorobots. Highly precise positioning techniques are required in Miniaturing in chip technology, optics , micro mechanic, medicine , gene and biotechnology. The new manipulation technology is the desire to enter the micro and Nano world not only by viewing but also acting, alteringmicro andNanosized objects. Nanorobots plays a critical roles for many applications in the human body, such astargetingtumoral lesionsfor therapeutic purposes, miniaturization of the power source with an effective onboard controllable propulsion and steering system have prevented the implementation of such mobile robots.

The therapeutic properties of light have been known for thousands of years, but it was only in the last century that photodynamic therapy (PDT) was developed. It is an emerging modality for the treatment of a variety of diseases that require the killing of pathological cells (e.g. cancer cells or infectious micro-organisms) or the removal of unwanted tissue (e.g. neovascularization in the choroid or atherosclerotic plaques in the arteries). It is based on the excitation of nontoxic photosensitizers.Photodynamic therapy(PDT) uses the combination of dyes with visible light to produce reactive oxygen species and kill bacteria and destroy unwanted tissue. Nanotechnology plays a great role insolubilizing thephotosensitizers, metal nanoparticles can carry out Plasmon resonance enhancement, andfullerenescan act as photosensitizers, themselves.

Nanotechnology is becoming increasingly important for the several sectors. Promising results and applications are already being developed in the areas of nutrient delivery systems through bioactive Nano encapsulation,biosensorsto detect and quantifypathogens organic compounds. The sensitivity and performance of biosensors is being improved by using nanomaterials for their construction. The use of these nanomaterials has allowed the introduction of many new signal transduction technologies in biosensors. Many scientists have involved themselves to know the application and the benefits of nanotechnology in different areas of food industry that include bioactive Nano encapsulation, edible thin film, packages andNano sensors.

Green chemistry and Nano science are both emerging fields that take advantage of molecular-level designing and have enormous potential for advancing our science. Nano science is the study of materials that are on the length-scale of 100 nanometers or smaller and have properties that are dependent on their physical size. The principles of green chemistry can guide responsible development of Nano science, while the new strategies of Nano science can fuel the development ofgreener productsand processes.Phytochemicalsoccluded in tea have been extensively used as dietary supplements and as naturalpharmaceuticalsin the treatment The parallel development of green chemistry and Nano science and the potential synergy of the two fields can lead to more successful and profitable technologies with reduced environmental impacts and improved conservation of resources. In recent years, green synthesis ofmetal nanoparticlesis an interesting issue of the nanoscience.

Nanotechnologyis enabling technology that deals with Nano-meter sized objects. It is expected that nanotechnology will be developed at several levels: materials, devices and systems. The combination of biology and nanotechnology has led to a new generation ofNano devicesthat opens the possibility to characterize the chemical, physical, mechanical, and other molecular properties. And it can be even used to characterize the single molecules or cells at extraordinarily high throughput.Nanoparticleswith distinctive chemical compositions, sizes, shapes, and surface chemistries can be engineered easily and this technique has wide range of applications in biological systems.Utility of nanotechnology to biomedical sciences imply creation of materials and devices designed tointeraction in sub-cellular scaleswith a high degree of specificity.

Biopolymer nanoparticles are offering numerous advantages which embrace the simplicity of their preparation from well-understood biodegradable, biocompatible polymers and their high stability inbiological fluidsduring storage. Since the emergence of Nanotechnology in the past decades, the development and design of organic andbioorganic nanomaterialshas become an important field of research. And several types of polymers have been tested and are used in drug delivery systems; including nanoparticles, dendrimers, capsosomes and micelles. Researchers have found, the synthesized polymers even serves as a good carrier and plays a vital role in carrying a drug. And in other hand they are used in food industries too for food package purposes. There are thousands of organic chemicals are in present in various pharmaceutical to consumer product and are being used in dyes, flavoring agents. It can be explained in organic compounds ranging in diameter from 10 to 1m.Ultrafine particlesare the same asnanoparticlesand between 1 and 100 nanometers in size, fine particles are sized between 100 and 2,500 nanometers, and coarse particles cover a range between 2,500 and 10,000nanometers.

The biological synthesis ofnanoparticlesis synthesis method through which we can control, size and shape of nanoparticles and it increasingly regarded as a rapid, ecofriendly, and easily scaled-up technology. Over the past few years researches have shown their interest inmetallic nanoparticlesand their synthesis has greatly increased. However, drawbacks such as the involvement oftoxic chemicalsand the high-energy requirements of production. Synthesizing living organisms such as bacteria, fungi and plants is an alternative way to overcome the drawbacks. Plant mediated synthesis of nanoparticles is the green chemistry that connects. Generally, metal nanoparticles are synthesized and stabilized by using physical and chemical: the chemical approach, such as chemical reduction,electrochemical techniques,photochemical reactionsin reverse micelles. There is a growing attention to biosynthesis the metal nanoparticles using organisms. Among these organisms, plants seem to be the best candidate and they are suitable for large scale biosynthesis of nanoparticles.

Nanoparticles used asdrug deliveryvehicles are generally below 100 nm , and are coated with different biodegradable materials such as natural or synthetic polymers (PEG,PVA,PLGA,etc.), lipids, or metals , it plays significant role on cancer treatment as well as it holds tremendous potential as an effective drug delivery system. A targeted drug delivery system (TDDS) is a system, which releases the drug in a controlled manner. Nanosystems with different compositions and biological properties have been extensively investigated for drug and gene delivery applications. To achieve efficient drug delivery it is important to understand the interactions ofNanomaterialswith the biological environment, targetingcell-surface receptors, drug release, multiple drug administration, stability of therapeutic agents. Nanotechnology refers to structures roughly in the 1100 nm size regime in at least one dimension. Despite this size restriction, nanotechnology commonly refers to structures that are up to several hundred nanometers in size and that are developed bytop-down or bottom-up engineering of individual components.

Nanosuspention formulation can be used to improve the solubility of the poorly soluble drugs. One of the major problems associated with poorly soluble drugs is very low bioavailability. The Preparation ofNanosuspentionis simple and applicable to all drugs which are water insoluble. It consists of the pure poorly water-soluble drug without any matrix material suspended in dispersion . Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include physical and chemical modifications of drug and other methods like particle size reduction,crystal engineering, salt formation, solid dispersion, use ofsurfactant, complexation A range of parameters like solubility, stability at room temperature, compatibility with solvent, excipient, andphotostabilityplay a critical role in the successful formulation of drugs. Use of some drug which is potentially restricted because of its toxic side-effects and its poor solubility, making it unsuitable for intravenous use in patients withdrug malabsorption.

Nano medicine drives the convergence of nanotechnology and medicine it is delineated as the application of nanotechnology in healthcare. The field of tissue engineering has developed in phases: initially researchers searched for inert biomaterialsto act solely as replacement structures in the body. Tissue engineering is classified as an associate field of biomaterialsand engineering. It focuses on the use of cellular and material-based therapies aimed attargeted tissue regenerationcaused by traumatic, degenerative, and genetic disorders.It covers a broad range of applications, in practice the term has come to represent applications that repair or replace structural tissues (i.e., bone, cartilage, blood vessels, bladder, etc.). Today, these Nano scale technologies are coming to the forefront in medicine because of their biocompatibility, tissue-specificity, and integration and ability to act as therapeutic carriers.

Polymeric nanoparticles (NPs) are one of the most studied organic strategies for Nano medicine. Intense interest lies in the potential ofpolymeric NPsto revolutionize modern medicine. Polymeric NPs include drug delivery techniques such as conjugation and entrapment of drugs,prodrugs, stimuli-responsive systems,imaging modalities, and theranostics.The use of biodegradable polymeric nanoparticles (NPs) for controlled drug delivery has shown significanttherapeutic potential. Concurrently, targeted delivery technologies are becoming increasingly important as a scientific area of investigation. Polymericnanoparticles-based therapeutics show great promise in the treatment of a wide range of diseases, due to the flexibility in which their structures can be modified, with intricate definition over their compositions, structures and properties. Advances in polymerizationchemistries and the application of reactive, efficient andorthogonal chemicalmodification reactionshave enabled the engineering of multifunctional polymericnanoparticles.

In recent years,microbubbleand Nano bubble technologies have drawn great attention due to their wide applications in many fields of science and technology, such as water treatment,biomedical engineering, and nanomaterials.Nano bubblesexhibit unique characteristics; due to their minute size and high internal pressure, they can remain stable in water for prolonged periods of time. Nanobubbles can be created whengold nanoparticlesare struck by short laser pulses. The short-lived bubbles are very bright and can be made smaller or larger by varying the power of the laser. Because they are visible under a microscope, nanobubbles can be used to either diagnose sick cells or to track the explosions that are destroying them.

Natural productshave been used in medicine for many years. Many top-sellingpharmaceuticalsare natural compounds or their derivatives.. And plant- or microorganism-derived compounds have shown potential as therapeutic agents against cancer, microbial infection, inflammation, and other disease conditions. Natural products had huge success in the post-World War II era as antibiotics, and the two terms have become synonymous.While large pharmaceutical companies have favored screening synthetic compound libraries for drug discovery, small companies have started to explore natural products uses against cancer, microbial infection, inflammation, and other diseases.The incorporation of nanoparticles into a delivery system for natural products would be a major advance in the efforts to increase their therapeutic effects. Recently, advances have been made showing that nanoparticles can significantly increase the bioavailability of natural products bothin vitro and in vivo.

Nanoscience and nanotechnology are new frontiers of this century and food nanotechnology is an emerging technology. Food technology is regarded as one of the industry sectors where nanotechnology will play an important role in the future. The development of new products and applications involving nanotechnologies holds great promise in different industrial sectors, Nanotechnology may revolutionize the food industry by providing stronger, high-barrier packaging materials, more potentantimicrobial agents. Several possibilities exist to exploit the benefits of nanotechnologies during different phases of the food chain with the aim to enhance animal nutrition and health. Several complex set of engineering and scientific challenges in the food and bioprocessing industries for manufacturing high quality and safe food through efficient and sustainable means can be solved through nanotechnology. Bacteria identification and food quality monitoring using biosensors; intelligent, active, and smart food packaging systems; and Nanoencapsulationofbioactive food compoundsare few examples of emerging applications of nanotechnology for the food industry.

The main current applications of Nanotechnology for surgeons are in the areas of development of surgical implants using Nanomaterials, Imaging, Drug Delivery and development of Tissue Engineering products, such as scaffolds with enhanced materialcell interaction. An example of this is the development of a scaffold for delivery of stem cells to replace defective retinal pigmented epithelial cells in age-related Macular Degeneration. In Dentistry research has been done, liposomal Nanoparticles that contained collagenase and performed tests with them in rats, and found compared to conventional surgery, collagenase weakened the collagen fibers, making it easier to shift the teeth afterward with braces.

Nanoparticles with their unique size-dependent properties are at the forefront of advanced material engineering applications in several fields. Metals, non-metals, bio-ceramics, and manypolymeric materialsare used to produce nanoparticles of the respective materials. These are functional in producing liposomes, PEG and many more. Due to their small size nanoparticles has found to be interacting with human bodies same like of gases. Nanoparticles of the same composition can display behavioral differences when interacting with different environments. Nanoparticles can enter the human body via inhalation, ingestion, or skin contact. The range of pathologiesrelated to exposure tonanoparticles encompasses respiratoryand even several organs and leads to diseases. Accurate in vitro assessment ofnanoparticle cytotoxicityrequires a careful selection of the test systems. Due to high adsorption capacity and optical activity, engineered nanoparticles are highly potential in influencing classical cytotoxicity assays.

One of the exciting features of nanotechnology is its utility in the field of Nano medicine, therapeutics, and medical devices . When these small size materials are introduced into biological systems, their extremely small size and their unique Nano scale properties make it possible to use them as delivery vectors and probes for biological diagnostics,bioimagingand therapeutics. In fact, when size decreases, thesurface area to volume ratioof materials becomes very large, so that a vast suitable surface is available forchemical interactions withbiomolecules. This critically implied that nanotechnology is facing a transition into the tangible advancement ofhuman therapeutics. Recently, There are multiple clinical trials of nanomaterials have done; both for therapeutics and for medical devices.

Related Societies:

USA:International Organization of Materials, International Association of Nanotechnology, Graphene Stakeholders Association, Nano Science and Technology Institute (NSTI),NanoBusiness Commercialization Association, Alliance for Nanotechnology in Cancer,International association of nanotechnology,National Institute for Nanotechnology, Waterloo Institute for Nanotechnology, The Institute for Molecular Manufacturing (IMM),NanoBusiness Alliance, Nanotechnology and Nanoscience Student Association (NANSA),Nano Science and Technology Institute (NSTI),National Cancer Institute, National Nanotechnology Initiative,American Nano society, Metals and Minerals Societies, Society for Advancement of Material and process Engineering,American Composites Manufacturers Association, Brazilian Composites Materials Association,Canadian Biomaterials Society, American Institute of Aeronautics and Astronautics (AIAA).

Europe:International Union of Crystallography, European Nanoscience and Nanotechnology Association (ENNA),German Association of Nanotechnology, Nanotechnology Industries Association, The Institute of Nanotechnology (IoN), Nanotechnology Industries Association (NIA),Russian Society of Scanning Probe Microscopy and Nanotechnology, Society of Nanoscience and Nanotechnology, Federation of Materials Societies, Society for Biomaterials, Federation of European Materials Societies

Asia-Pacific & Middle East:Nano Technology Research Association (NTRA), Asian Nanoscience and Nanotechnology Association (ANNA), Nanoscience & Nanotechnology, ASPEN-Asian society of precision engineering and nanotechology, The International Association of Nanotechnology (IANT), Iran Nanotechnology Initiative Council (INIC), National Institutes of Health, Society of Materials Science, Japan Society for Composite Materials, Australasian Society for Biomaterials and Tissue Engineering, Australasian Ceramic Society, Materials Research Society, National Centre for Nanoscience and Technology.

Theme: Role of Nanotechnology in Humans life

Summary:

The field of Nanotechnology has recently emerged as the most commercially viable technology of this century because of its wide-ranging applications in our daily lives. Man-made Nanostructured materials such as fullerenes, nanoparticles, Nano powders, Nanotubes, Nanowires, Nanorods, Nano-fibers, Quantum dots, Dendrimers, Nano clusters, Nanocrystals, and Nanocomposites are globally produced in large quantities due to their wide potential applications, e.g., in skincare and consumer products, healthcare, electronics, photonics, biotechnology, engineering products, Pharmaceuticals, drug delivery, and agriculture. Many emerging economies such as Brazil, China, India, Iran, UAE, Malaysia, Mexico, Singapore and South Africa have ambitious research and development (R&D) plans for Nanotechnology.A group of scientists who have mapped out the uses of Nanotechnology and the needs of global health argue that Nano medicine is relevant for the developing world. They surveyed researchers worldwide and concluded that Nanotechnology could greatly contribute to meeting the Millennium Development Goals for health.

Importance and scope:

Nanotechnologyis becoming a crucial driving force behind innovation in medicine and healthcare, with a range of advances including Nano scale therapeutics, biosensors, implantable devices, drug delivery systems, and imaging technologies. Universities also have begun to offer dedicated Nano medicine degree programs (example:MSc program in Nanotechnology for Medicine and Health Care). Nanotechnology will be getting to be progressively prevalent these times Around learners. Actually, if you follow again of the Inception about nanotechnology, you will discover that Ayurveda need long been utilizing gold Also silver nanoparticles, known as bhasmas, to treat Different therapeutic ailments. Presently, nanotechnology may be generally utilized within huge numbers industries, going from cosmetics, agriculture, and materials should pharmaceutical Also human services. Nanomedicine may be the provision for nanotechnology for those diagnoses, detection, and medicine Also aversion of illnesses. Presently there need aid various items on the business that would the outcome from claiming nanotechnology. Talking for scratching the surface, we likewise have Nano auto wax that fills done the individuals minor cracks more successfully Furthermore provides for you a shinier vehicle. There need aid likewise Nano items accessible with stay with your eyewear What's more different optical units cleaner, dryer, What's more that's only the tip of the iceberg tough.

Conference highlights:

Why in Abu Dhabi?

Abu Dhabi is the federal capital and centre of government in the United Arab Emirates sits off the mainland on an island in the Persian (Arabian) Gulf. It is the largest city of the Emirate of Abu Dhabi and one of the most modern cities in the world. It is a well-ordered, industrious city with a pretty waterside location. Innovative Nano Technology LLC was founded in the beginning of 2016 in Al Ain City, Abu Dhabi, United Arab Emirates. It was established with the goal of taking a leading role in the field of Nano Technology Based Coatings, and is considered as one of the first Companies who offer the new Nano technology based Coatings in the region.

Why to attend?

United Arab Emirates has a number of universities that offer research and educational opportunities in nanotechnology. United Arab Emirates University, The first and foremost comprehensive National University in the United Arab Emirates. eFORS office is the University consultancy office within the college of engineering that deals with several science and technology issues including Biochemical and Biopharmaceutical Processes and Bioengineering and Nanotechnology. Reports released during October 2012 revealed that the worlds second largest foundry, Globalfoundries has agreed to partner with Masdar Institute to develop Abu Dhabi as a centre for semiconductor R&D and manufacturing excellence. In September, the company allowed students and professors to use its technology facilities at its Abu Dhabi branch. The facilities have a laboratory-like environment with powerful production servers, engineering work stations and a high-speed data network that can be used for enabling remote access to very advanced nanotechnology engineering systems

Technology domains of patent applications in UAE

This graph shows the global Nanomedicine market size, measured in terms of revenues, such as sales revenues, grants revenues, and milestones. From2006to date, a steady growth has occurred, which is expected to continue through2014, at aCAGRof13.5% [BCCResearch, Nanotechnology in Medical Applications. The drug delivery market is the largest contributing application segment, whereas biomaterials are the fastest growing application area in this market. Nanomedicine accounts for77Marketed Products Worldwide, representing an Industry with an estimated market $249.9Billion by2016[ETPNdata,BCC].

Globally, the industry players would centering essentially once R&D to get Regard for Different clinical trials for future Nanodrugs with a chance to be economically accessible in the business sector. If a chance to be generally arranged for exactly of the most punctual What's more The greater part essential requisitions of Nano medicine for regions for example, gene treatment and tissue building. The a greater amount propelled requisitions for Nano medicine will pose interesting tests As far as order Furthermore support about exploratory dexterity.

Nano medicine market :

Nano-enabled medical products beganappearing on the market over a decade ago and some have become best-sellers in theirtherapeutic categories. The main areas in which Nanomedical products have made animpact are cancer, CNS diseases, cardiovascular disease, and infection control. At present, cancer is one of the largesttherapeutic areas in which Nano-enabled products have made major contributions; theseinclude Abraxane, Depocyt, Oncospar, Doxil,and Neulasta. Cancer is a prime focus forNano pharmaceutical R&D, and companieswith clinical-stage developments in this fieldinclude Celgene, Access, Camurus, andCytimmune. Treatments for CNS disorders includingAlzheimers disease and stroke also feature prominently in Nano therapeutic research,seeking to build on achievements already posted by products such as Tysabri, Copazone,and Diprivan. According to BCC Research,this is a field hungry for successfultherapeutic advances and annual growth fromexisting and advanced pipeline products isexpected to reach 16% over the next 5 years.

Nanotechnology Companies in Asia and Middle East:

Nano Congress 2017

We gratefully thank all our wonderful Speakers, Conference Attendees, Students, Media Partners, Associations and Sponsors for making Nano Congress 2017 Conference the best ever!

The19thNano Congress for Next Generation, hosted by the ME Conferences was held duringAugust 31- September 01, 2017atBrussels, Belgiumbased on the themeNext Generation Nanotechnology Concepts Methodologies Tools and Applications". Benevolent response and active participation was received from the Organizing Committee Members along with Scientists, Researchers, Students and leaders from various fields of Nanotechnology who made this event a grand success.

ME Conferences expresses its gratitude to the conference Moderator,namelyDr.Dominique Ausserrefor taking up the responsibility to coordinate during the sessions. We are indebted to your support.

Similarly we also extend our appreciation towards our Poster judge namely,Dr. Arturs Medvids.

The conference was initiated with theHonorable presenceof theKeynote forum. The list includes:

The meeting reflected various sessions, in which discussions were held on the following major scientific tracks:

Nano Materials Synthesis and Characterisation

Nano Photonics

Molecular Nanotechnology

Nanotechnology and Cosmetics

Nanotechnology in Agriculture and Food Industry

Carbon Based Nano materials and Devices

Nanotechnology Safety

Nano Medicine and Nano Biotechnology

Nano Science and Technology

Nano Applications

Nano-electronics

Nano Biomaterials

Nano Biometric

Advanced Nanomaterials

Nano Technology in Tissue Engineering

Nanotech for Energy and Environment

Nano Computational Modelling

ME Conferences offers its heartfelt appreciation to organizations such asAllied Academies,Andrew John Publishing Inc.,New York private Equity Forum,Crowd Reviewsand other eminent personalities who supported the conference by promoting in various modes online and offline which helped the conference reach every nook and corner of the globe. ME Conferences also took privilege to felicitate the Keynote Speakers, Organizing Committee Members, Chairs and sponsors who supported this event

Excerpt from:

Nanomedicine Conferences | Nanotechnology Events ...

Nanomedicine – Official Site

Posted on September 19, 2018 by Dook Domini

The mission of Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine: NBM) is to promote the emerging interdisciplinary field of nanomedicine.

Nanomedicine: NBM is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results...

The mission of Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine: NBM) is to promote the emerging interdisciplinary field of nanomedicine.

Nanomedicine: NBM is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.

The potential scope of nanomedicine is broad, and we expect it to eventually involve all aspects of medicine. Sub-categories include synthesis, bioavailability, and biodistribution of nanomedicines; delivery, pharmacodynamics, and pharmacokinetics of nanomedicines; imaging; diagnostics; improved therapeutics; innovative biomaterials; interactions of nanomaterials with cells, tissues, and living organisms; regenerative medicine; public health; toxicology; point of care monitoring; nutrition; nanomedical devices; prosthetics; biomimetics; and bioinformatics.

Article formats include Communications, Original Articles, Reviews, Perspectives, Technical and Commercialization Notes, and Letters to the Editor. We invite authors to submit original manuscripts in these categories.

Excerpt from:

Nanomedicine - Official Site

Nanomedicine Fact Sheet – National Human Genome Research …

Posted on September 19, 2018 by Dook Domini

NanomedicineOverview

What if doctors had tiny tools that could search out and destroy the very first cancer cells of a tumor developing in the body? What if a cell's broken part could be removed and replaced with a functioning miniature biological machine? Or what if molecule-sized pumps could be implanted in sick people to deliver life-saving medicines precisely where they are needed? These scenarios may sound unbelievable, but they are the ultimate goals of nanomedicine, a cutting-edge area of biomedical research that seeks to use nanotechnology tools to improve human health.

Top of page

A lot of things are small in today's high-tech world of biomedical tools and therapies. But when it comes to nanomedicine, researchers are talking very, very small. A nanometer is one-billionth of a meter, too small even to be seen with a conventional lab microscope.

Top of page

Nanotechnology is the broad scientific field that encompasses nanomedicine. It involves the creation and use of materials and devices at the level of molecules and atoms, which are the parts of matter that combine to make molecules. Non-medical applications of nanotechnology now under development include tiny semiconductor chips made out of strings of single molecules and miniature computers made out of DNA, the material of our genes. Federally supported research in this area, conducted under the rubric of the National Nanotechnology Initiative, is ongoing with coordinated support from several agencies.

Top of page

For hundreds of years, microscopes have offered scientists a window inside cells. Researchers have used ever more powerful visualization tools to extensively categorize the parts and sub-parts of cells in vivid detail. Yet, what scientists have not been able to do is to exhaustively inventory cells, cell parts, and molecules within cell parts to answer questions such as, "How many?" "How big?" and "How fast?" Obtaining thorough, reliable measures of quantity is the vital first step of nanomedicine.

As part of the National Institutes of Health (NIH) Common Fund [nihroadmap.nih.gov], the NIH [nih.gov] has established a handful of nanomedicine centers. These centers are staffed by a highly interdisciplinary scientific crew, including biologists, physicians, mathematicians, engineers and computer scientists. Research conducted over the first few years was spent gathering extensive information about how molecular machines are built.

Once researchers had catalogued the interactions between and within molecules, they turned toward using that information to manipulate those molecular machines to treat specific diseases. For example, one center is trying to return at least limited vision to people who have lost their sight. Others are trying to develop treatments for severe neurological disorders, cancer, and a serious blood disorder.

The availability of innovative, body-friendly nanotools that depend on precise knowledge of how the body's molecular machines work, will help scientists figure out how to build synthetic biological and biochemical devices that can help the cells in our bodies work the way they were meant to, returning the body to a healthier state.

Top of page

Last Updated: January 22, 2014

See the article here:

Nanomedicine Fact Sheet - National Human Genome Research ...

Nano Medicine

Posted on August 2, 2018 by Dook Domini

December 12th, 2017 Filed under Nano Medicine Comments Off on Nanodelivery 2018 Conferences | Nanomedicine Meetings

Welcome Message

International Conference and Exhibition on Nanomedicine and Drug Delivery May 14-16, 2018 Tokyo, Japan

ConferenceSeries Ltdis a renowned organization that organizes highly notable Pharmaceutical Conferencesthroughout the globe. Currently we are bringing forthInternational Conference on Nanomedicine and Drug Delivery(NanoDelivery 2018) scheduled to be held duringMay 14-16, 2018 at Tokyo, Japan. The conferenceinvites all the participants across the globe to attend and share their insights and convey recent developments in the field of Nanomedicine and Drug Delivery.

ConferenceSeries Ltdorganizes aconference seriesof 1000+ Global Events inclusive of 1000+ Conferences, 500+ Upcoming and Previous Symposiums and Workshops in USA, Europe & Asia with support from 1000 more scientificsocietiesand publishes 700+Open access Journalswhich contains over 50000 eminent personalities, reputed scientists as editorial board members.

2018 Highlights:

Nanomedicine and drugdelivery will account for 40% of a $136 billion nanotechnology-enabled drug delivery market by 2021. We forecast the total market size in 2021 to be US$136 billion, with a 60/40 split between nano medicine and drug delivery respectively, although developing new targeted delivery mechanisms may allow more value to be created for companies and entrepreneurs.

However, the Asia-Pacific region is expected to grow at a faster CAGR owing to presence of high unmet healthcare needs, research collaborations and increase in nanomedicine research funding in emerging economies such as Japan, China, India and other economies in the region. Japan is expected to surpass the United States in terms of nanotechnology funding in the near future, which indicates the growth offered by this region.This conference seeks to showcase work in the area of Nanomedicine, Drug Delivery Systems, and nanotechnology, Nanobiothechnology, particularly related to drug delivery.

For More PS: http://nanomedicine.pharmaceuticalconferences.com/

(Click here for any queries)

Nanomedicine and drugdelivery can address one of the greatest challenges in the post-genomic era of the 21st century making the essential connections between Academics and industry professionals.

To meet these challenges, the field of Nanomedicine and drugdelivery has undergone exponential growth during the last 5 years. Technologies such as Personalized Nanomedicine, Design of Nanodrugs, Synthesis of Nanoparticles for Drug Delivery, Regenerative Medicine and Tissue Engineering, Nanomedicines and Biomedicalapplications, Nanomaterials for drug delivery, Regulatory Aspects Towards Approval of Nanomedicine, NanoPharmaceutical Industry and Market processing and drug delivery promise to transform the world of nanomedicines and drug delivery much in the same way that integrated and transformed the world of pharmaceutical sciences.

Nanodelivery 2018 has everything you need:

Open panel discussions: Providing an open forum with experts from academia and business to discuss on current challenges in nanomedicine and drugdelivery, where all attendees can interact with the panel followed by a Q&A session.

Speaker and poster presentations: Providing a platform to all academicians and industry professionals to share their research thoughts and findings through a speech or a poster presentation.

Editorial board meeting: Discussing on growth and development of open access Nanomedicine and drugdelivery International Journals and recruiting board members and reviewers who can support the journal.

Round table meetings: Providing a platform where industry professionals meet academic experts.

Over 50+ organizations and international pavilions will be exhibiting at the Nanodelivery 2017 conference and Exhibition. Exhibitors will include equipment manufacturers and suppliers, systems providers, finance and investment firms, R&D companies, project developers, trade associations, and government agencies.

In addition to the products and services you will see at the Nanodelivery Exhibition, you will have access to valuable content, including Keynote Presentations, Product Demonstrations and Educational Sessions from todays industry leaders.

The Nanodelivery 2018 has everything you need, all under one roof, saving you both time and money. It is the event you cannot afford to miss!

Whos Coming to Nanodelivery 2018?

The field of Nano Delivery now has pivotal roles in electronics, biology and medicine. Its application can be appraised, as it involves the materials to be designed at atomic and molecular level. Due to the advantage of their size, nanospheres have been shown to be robust drug delivery systems and may be useful for encapsulating drugs and enabling more precise targeting with a controlled release. In this review specifically, we highlight the recent advances of this technology for medicine and drug delivery systems. Nanomaterials range from 10200 nm up to a few micrometres in size, and include nano- and microparticles, nanotubes and quantum dots.

Nanotechnological devices are made from metals, polymers, lipids and organic substances as well as from macromolecules such as dendrimers, antibodies, micelles, liposomes and nanofibers. Nanomedicine makes use of these nanostructures for diagnostic or therapeutic applications in all fields of medicine, using them for drug delivery, biosensors, neuro-electronic interfaces, in vivo imaging, and cell-specific molecular interactions, where cell repair machines could revolutionize medicine and the medical field. As drug delivery systems, nanoparticles can be designed to improve the pharmacological and therapeutic properties of drugs. The strength of nanoparticulate drug delivery systems is their ability to alter the pharmacokinetics and biodistribution of drugs.

ConferenceSeries Ltdorganizes aconference seriesof 3000+ Global Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops in USA, Europe & Asia with support from 1000 more scientificsocietiesand publishes 700+Open access journalswhich contains over 30000 eminent personalities, reputed scientists as editorial board members.

Track 1: Nanomedicine

Nanomedicine seeks to deliver a valuable set of research tools and clinically useful devices. The pharmaceutical industry is developing new commercial applications that may include advanced drug delivery systems, new therapies, and Nanomaterials for Imaging and Drug Delivery. Another active and very much related area of research is the investigation of toxicity and environmental impact of nanoscale materials, since nanomedicines must be biocompatible for clinical application.

Related Conferences:

Nanomaterials Conference,March 30-31, 2017, Madrid, Spain;MedicalNanotechnologySummitMay 22-23, 2017, Osaka, International Conference onPharmaceutics and Drug Delivery, March 13-15, 2017 London, UK; 2ndInternational Conference onNanomedicine, Drug Delivery, and Tissue Engineering, April 05-06, 2017, Barcelona, Spain; 19th International Conference onNanotechnology and Nanomedicine, July 9 10, 2017, Prague, Czech Republic; EuropeanNanomedicineMeeting 2017, April 3-4, 2017, London, UK; 19thInternational Conference onNanotechnology and Nanomedicine, June 21 22, 2017, Vienna, Austria; 4thWorld Congress and Expo onNanotechnology and Materials Science, April 05-07, 2017, Barcelona, Spain. Nano Canadian Society,American Nano Society,American Society for Nanomedicine,Society for Personalized Nanomedicine,Royal Society-NanoTechnology and NanoScience.

Track 2: Design of Nanodrugs

To reach target cell, designing of nanodrugs are major aspects, where researcher interested for developing novel Nanodrugs.

Aimed and specially designed session for researchers developing Nanodrugs for delivery of amino acids, Nucleic acids and proteins. The session Design of Nanodrugs includes: Novel Drugs to Nano Drugs, Nanodrugs for Cancer Therapy, Nanodrugs for Veterinary Therapeutics, Nanodrugs for Medical applications and Nanodrugs for Herbal medicines and Cosmetics.

Related conferences:

Track 3: Nanomedicine and Nanotechnology

Nanotechnology for cancer is a field that incorporates the studies related to nanosized particles, their function and behavior with respect to different systems. The tremendous capabilities of nanoparticles have changed the perspective and scope of nanotechnology towards development into an adjuvant field for the remaining fields of life sciences. The role of nanotechnology in the field of pharmaceutics has tremendously changed the way of our understanding about drugs, nanodrugs or the use of nanoparticles as carrier of drug has become the basic fundamental or criteria for the production or design of a drug and advances in nanotechnology.

Nanotechnology is an important field of modern research dealing with design, synthesis, and manipulation of particle structures ranging from approximately 1-100 nm.

The session Design of Nanomedicine and Nanotechnology includes broad topics like: Carbon Nanotubes, Nanoparticles, Gold Nanoparticles, Silver Nanoparticles, Magnetic Nanoparticles, Nano Micro Particles, Nanocomposite Microspheres, Biosensors and Nanobioelectronics, Bio inspired materials and drug delivery and Nanobiomechanics and Nanomedicine.

Related conferences:

Track 4: Synthesis of Nanoparticles for Drug Delivery

Nanoparticles (NPs) have wide range of applications in areas such as health care, cosmetics, food and feed, environmental health, mechanics, optics, biomedical sciences, chemical industries, electronics, space industries, drug-gene delivery, energy science, optoelectronics, catalysis, single electron transistors, light emitters, nonlinear optical devices, and photo-electrochemical applications.

Synthesizing nanoparticles for pharmaceutical purposes such as drug preparation can be done in two methods. Bottom up process such as pyrolysis, inert gas condensation, solvothermal reaction, sol-gel fabrication and structured media in which hydrophobic compound such as liposomes are used as bases to mount the drug. Top down process such as attrition / milling in which the drug is chiseled down to form a nanoparticle

Nanocarriers, Gold Nanoparticles, Silver Nanoparticles, Liposomes, ligands, Nanoemulsions , Solid Lipid Nanoparticles, Polymeric Nanoparticles, Dendrimer Nanocarriers, Silica materials and Carbon Nanocarriers, nanotechnology and medicine.

Related conferences:

Nanomaterials Conference March 30- 31, 2017 Madrid,Spain; MedicalNanotechnologySummit May 22-23, 2017 Osaka, Japan; Molecular Nanoscience Meeting October 20-22, 2016 Rome, Italy; Nanotechnology Expo November 10-12 2016, Australia; Nanotech Expo December 5-7 2016, USA; International Conference onNanoscienceand Nanotechnology (ICONN), 711 February 2016, Australia; International Conference onNanobiotechnology, Drug Delivery, and Tissue Engineering, 1st- 2ndApril 2016, Czech Republic; International Conference on Biotechnology, Bioengineering andNanoengineering, April 14-15, 2016, Portugal; Meeting and Expo onNanomaterialsand Nanotechnology, 25th 27th April 2016, UAE;NANOTEXNOLOGY, 29 July, 2016, Greece. Nano Canadian Society, American Nano Society, American Society for Nanomedicine, Society for Personalized Nanomedicine.

Track 5: Regenerative Medicine and Tissue Engineering

The promise of regenerative medicine is truly remarkable. Regenerative medicine is a new branch of medicine that attempts to change the course of chronic disease, in many instances regenerating failing organ systems lost due to age, disease, damage, or congenital defects. The area is rapidly becoming one of the most promising treatment options for patients suffering from tissue failure.

Tissue Engineering and Regenerative Medicine is appealing to scientists, physicians, and lay people alike: to heal tissue or organ defects that the current medical practice deems difficult or impossible to cure.

It covers numerous topics, such as stem cells, cell culture, polymer synthesis, novel biomaterials, drug delivery, therapeutics, and the creation of tissues and organs.

This session dedicated to helping provide research-based solutions to issues related to human diseases and include with sessions as: tissue engineering, Organ fabrication, Tissue printing, Biomaterials, Biologic scaffolds, Hydrogels, Cell seeded matrices, Bioreactor design, Mechanical conditioning of engineered tissues, Mechanical properties of engineered tissues, Physiological properties of engineered tissues, Clinical outcomes of engineered tissue implantation, Cell-based therapies.

Related conferences:

Tissue Engineering and Regenerative Medicine Conference Aug 20-22, 2017 Baltimore, USA; Stem Cell And Regenerative Medicine Meetings March 20-22, 2017 Berlin, Germany; 8thWorld Congress on Stem Cell ResearchMarch 20-22, 2017 Orlando, USA; 5th International Conference onCell and Gene TherapyMay 19-21, 2016 San Antonio, USA; InternationalConference on Restorative MedicineOctober 24-26, 2016 Chicago, USA; InternationalConference on Molecular BiologyOctober 13-15, 2016 Dubai, UAE; 2nd InternationalConference on Tissue preservation and Biobanking September12-13, 2016 Philadelphia USA;Conference on Cardiac Development, Regeneration and RepairApril 3 7, 2016 Snowbird, Utah, USA; The Conference onStem Cell Development,May 22-26, 2016 Hillerd, Denmark;Conference onHematopoietic Stem Cells: June 3-5, 2016 Heidelberg, Germany; ISSCR Pluripotency Conference March 22-24, 2016 Kyoto, Japan , Royal Society-NanoTechnology and NanoScience, International Association of Nanotechnology (IANT), American Association for the Advancement of Science , Nano Canadian Society, American Nano Society, American Society for Nanomedicine, Society for Personalized Nanomedicine.

Track 6: Nanomedicine in Theranostics

Theranostic nanomedicine is emerging as a promising therapeutic paradigm. It takes advantage of the high capacity of nanoplatforms to ferry cargo and loads onto them both imaging and therapeutic functions. The resulting nanosystems, capable of diagnosis, drug delivery and monitoring of therapeutic response, are expected to play a significant role in the dawning era of personalized medicine, and much research effort has been devoted toward that goal.

Related Conferences:

Track 7: Nanomedicines and Biomedical Applications

Track 8: Drug Delivery Research

Drug Delivery Conferences attains greater global significance as Drug Delivery plays a significant role in the future of pharmaceutical research Novel drug delivery system method by which a drug is delivered can have a significant effect on its efficacy. Conference includes topics like lipid Polymers to enhance drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and hydrophobic drugs. In vitro & in vivo dissolution testing is required to ensure that drug dissolves at a consistent rate from batch to batch of formulated drug product. Improvement of dissolution rate of poorly soluble drugs can be increased by dissolving them in liquid hydrophilic vehicles followed by soaking on highly porous materials. The major part is to deliver an innovative speech on the latest Targeted drug delivery is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others. Pharmacokinetic behavior in drug design and drug development for safety issues arising either as a result of animal toxicity testing or in the clinical program itself

Related Conferences:

10th Pharmaceutics and Novel Drug Delivery Systems Conference, March 13-15, 2017 London, UK; 6th Annual Conferences on European Pharma Congress, July 10-12, 2017 Madrid, Spain; 3nd International Conference on Biopharmaceutics June 22-23, 2017 Baltimore, USA; 3nd International Conference on Biologic Drugs, June 22-23, 2017 Baltimore, USA; 6rd World Congress on Pharmacology August 7-9, 2017 Paris, France; 2nd International Conference on Parenterals, December 05-07, 2016 Texas, USA; 2nd International Conference on Injectables December 05-07, 2016, Texas, USA; Respiratory Drug Delivery Conference, April 25-28, 2017 France; Drug Delivery Partnership, February 7-9, 2017 Florida USA; 6th International Conference on Drug Formulation, 6thInternational Conference on Solubility March 20-22, 2017 Philadelphia, USA, 6th International Conference on Bioavailability, March 20-22, 2017 Philadelphia, USA; Congress on Innovation in Drug Delivery (APGI), Controlled Release Society (CRS), International Society for Aerosols in Medicine (ISAM), The Pharmaceutical and Healthcare Sciences Society (PHSS), Nano Canadian Society, American Nano Society, American Society for Nanomedicine, Society for Personalized Nanomedicine.

Track 9: Novel Drug Delivery Systems

To maximize knowledge of the current researcher on developing drug delivery systems via Novel techniques for Pharmaceutical formulation development, Drug Delivery conference themed quality topics on Liposomes, Dendrimer, Targeted Drug Delivery design, versatile polymer in Drug Delivery and Controlled Drug Delivery, Trans mucosal Drug Delivery, Blood Brain Barrier, Optimization of pharmaceutical products, Sustained Drug Delivery Systems, are a uniquely architect session to play an important role in the fields of pharmaceutical formulation development and Pharmacology.

Related Conferences:

Track 10: Smart Drug Delivery Technology

To maximize knowledge of the current researcher on developing drug delivery via Pharmaceutical formulation, Smart Drug Delivery conference themed quality topics on Drug Targeting, Drug Designing, Drug evaluation, Drug Delivery and Therapeutics, Biodegradable polymers, Dendrimer a versatile polymer in drug delivery are a uniquely architect session to play an important role in the fields of nanotechnology, pharmaceutical and medicinal chemistry.

Major drugs driving growth of the overall smart drug delivery market include Angiomax, Copaxone, Forteo, Sandostatin, Velcade, Victoza and Zoladex

Related Conferences:

10th Pharmaceutics and Novel Drug Delivery Systems Conference, March 13-15, 2017 London, UK; 6th Annual Conferences on European Pharma Congress, July 10-12, 2017 Madrid, Spain; 3rd International Conference on Biopharmaceutics June 22-23, 2017 Baltimore, USA; 3rd International Conference on Biologic Drugs, June 22-23, 2017 Baltimore, USA; 6rd World Congress on Pharmacology August 7-9, 2017 Paris, France; 2nd International Conference on Parenterals, December 05-07, 2016 Texas, USA; 2nd International Conference on Injectables December 05-07, 2016, Texas, USA; Respiratory Drug Delivery Conference, April 25-28, 2017 France; Drug Delivery Partnership, February 7-9, 2017 Florida USA; 6th International Conference on Drug Formulation, 6thInternational Conference on Solubility March 20-22, 2017 Philadelphia, USA, 6th International Conference on Bioavailability, March 20-22, 2017 Philadelphia, USA; Congress on Innovation in Drug Delivery (APGI), Controlled Release Society (CRS), International Society for Aerosols in Medicine (ISAM), The Pharmaceutical and Healthcare Sciences Society (PHSS), Nano Canadian Society, American Nano Society, American Society for Nanomedicine, Society for Personalized Nanomedicine.

Track 11: Nano Pharmaceuticals

Pharmaceutical Nanotechnology for Drug Delivery using Nanotechnology session plays major role in the future of pharmaceutical research. In this session, we will go over several of the most important features of nanotechnology, anticancer drug development , pharmocology of cancer drugs, that will impact our lives but we will also talk about what nanotechnology itself will be like in the future and Investigator specifically from cancer therapy. Interestingly pharmaceutical sciences are using nanoparticles to reduce toxicity and side effects of drugs and up to recently did not realize that carrier systems themselves may impose risks to the patient.

Nano technology session includes drug delivery using nanotechnology, Pharmaceutical technology, Nanoparticles permeability to BBB, Cancer drug targets, Nanoparticles application, Pancreatic Cancer, Nanoliposome-mediated delivery, MicroRNA therapeutics, recent breakthroughs in nanoparticle design to demonstrate their high potential as multifunctional drug delivery nanocarrier, Carriers for nanotechnology, various nanostructures, magnetic nanoparticles. In this review Polymer Nanotechnology for Drug Delivery, Nano composite materials, to deliver highly efficient therapeutic compounds to patient a future aspect of Nanotechnology has a vast future ahead of it and we are constantly making breakthroughs in this industry every day.

Related Conferences:

20th International Conference on Nanoscience, Dec 19-20, 2017 Osaka, Japan 11th International Conference on Molecular Nanotechnology, October 20-22, 2016 Rome, Italy, UK; International Conference on Nano medicine, July 24-25, 2017 Melbourne, Australia; Conference on Nanotechnology in Health Care , July 24-25, 2017 Melbourne, Australia; 3rd International Conference on Biopharmaceutics June 22-23, 2017 Baltimore, USA; 3rd International Conference on Biologic Drugs, June 22-23, 2017 Baltimore, USA; 6rd World Congress on Pharmacology August 7-9, 2017 Paris, France; 2nd International Conference on Parenterals, December 05-07, 2016 Texas, USA; 2nd International Conference on Injectables December 05-07, 2016, Texas, USA; Respiratory Drug Delivery Conference, April 25-28, 2017 France; Drug Delivery Partnership, February 7-9, 2017 Florida USA; 6th International Conference on Drug Formulation, 6thInternational Conference on Solubility March 20-22, 2017 Philadelphia, USA, 6th International Conference on Bioavailability, March 20-22, 2017 Philadelphia, USA; Congress on Innovation in Drug Delivery (APGI), Controlled Release Society (CRS), International Society for Aerosols in Medicine (ISAM), The Pharmaceutical and Healthcare Sciences Society (PHSS), Nano Canadian Society, American Nano Society, American Society for Nanomedicine, Society for Personalized Nanomedicine.

Track 12:Biopharmaceutics and Biologic Drugs

Biopharmaceutics is defined as the study of factors influencing the rate and amount of drug that reaches the systemic circulation and the use of this information to optimise the therapeutic efficacy of the drug products. The process of movement of drug from its site of administration to the systemic circulation is called as absorption. The concentration of drug in plasma and hence the onset of action, and the intensity and duration of response depend upon the bioavailability of drug from its dosage form. Bioavailability is defined as the rate and extent (amount) of drug absorption.Biologic Drugs, or biologic response modifiers, are medications genetically engineered from a living organism, such as a virus, gene or protein, to simulate the bodys natural response to infection and disease. Biologics target proteins, cells and pathways responsible for the symptoms and damage of rheumatoid arthritis and other types of inflammatory arthritis. Biologic response modifiers (biologics for short) are drugs that are genetically engineered from a living organism, such as a virus, gene or protein, to simulate the bodys natural response to infection and disease.

Related conference:

13th International Conference on Biopharma and Biotherapeutics October 24-25, 2018 Boston, Massachusetts, USA , Global Summit on Biopharma and Biotherapeutics Montreal, Canada May 14-15, 2018, International Conference on Nano Medicine and Nanoparticles April 18-19, 2018 Las Vegas, USA 11th European Biosimilars Congress April 26-27, 2018 Rome, Italy

Track 13: Nano Biotechnology

Nanobiotechnologyis the intersection of nanotechnology and biology. Nanobiotechnology has multitude of potentials for advancing medical science thereby improving health care practices around the world. Nanomedicine is used to treat diseases bygene therapy. Nano biotechnologies are being applied to molecular diagnostics and several technologies are in development.

Related Conferences:

Track 14: Nano Pharmaceutical Industry and Market

Nano Pharmaceutical Industry Companies and Market session is beginning to change for small, medium, and large scale pharmaceutical Co, biopharmaceutical Manufacturing and Industries, generic drugs companies, contract drug delivery companies which can manifest from development to manufacturing. Addressing these instabilities is a great challenge, because of the complexity of the Clinical bio therapeutics themselves. This session includes Rheological behavior, Pharmaceutical Guidelines, Pharmaceutical companies and regulatory guidelines perspectives, Advances in computational modeling for bioavailability, drug Stability of Pharmaceutical products which are driving crucial research into new vaccines and medicines. The pharmaceutical industry and the public sector are thinking differently than before about how to improve access to medicines and advance research and development for neglected diseases.

Related Conferences:

International Conference on Pharma Marketing Conference, November 17-19, 2016 Alicante, Spain; 4th Annual conferences on European Pharma Congress, June 13-15, 2016 Berlin, Germany; 2nd International Conference on Biologic Drugs, September 15-17, 2016 San Antonio, USA; 3rd World Congress on Pharmacology August 08-10, 2016 Birmingham, UK; 2nd International Conference on Parenterals, December 05-07, 2016 Dallas, Texas, USA; 2nd International Conference on Injectables December 05-07, 2016 Dallas, Texas, USA; Respiratory Drug Delivery Conference, April 25-28, 2017 France; Drug Delivery Partnership, February 7-9, 2017 Florida USA; 6th International Conference on Drug Formulation, 6thInternational Conference on Solubility March 20-22, 2017 Philadelphia, USA, 6th International Conference on Bioavailability, March 20-22, 2017 Philadelphia, USA; Congress on Innovation in Drug Delivery (APGI), Controlled Release Society (CRS), International Society for Aerosols in Medicine (ISAM), The Pharmaceutical and Healthcare Sciences Society (PHSS), Nano Canadian Society, American Nano Society, American Society for Nanomedicine, Society for Personalized Nanomedicine.

Track 15: Regulatory Aspects Towards Approval of Nanomedicine

Nanoethicsis the study ethical and social implications of nanotechnologys. It is an emerging but controversial field.Nanoethics is a debatable field.As the research is increasing on nanomedicine, there are certain regulations to increase their efficacy and address the associated safety issues. Other issues in nanoethics include areas likeresearch ethics, environment,global equity, economics, politics, national security, education, life extension and space exploration.

Related Conferences:

Summary of Nanodelivery 2018 Conference:

Nano Delivery 2018is an emerging field of engineering and life sciences that promises to revolutionize medicine and medical technology. There are numerous applications of nanomedicine and Drug Delivery using Nanotechnology in medicinal diagnostics. These include improved imagining of the human (or any) body and detecting tumors that are only a few cells in size.

The idea that pharmaceutical agents should be delivered specifically to diseased cells holds the promise of a variety of benefits. The promise of individualized medicine is that it is efficient. Targeted drug-delivery allows doctors and patients to benefit from small dosages at just the right place and thus from fewer side effects.

Nanomedicine has therapeutic uses as well. Nanotechnology is capable of delivering medication to the exact location where they are needed, hence lesser side effects. It can also be used to destroy harmful organisms or cancer cells by interrupting their division process. Nanoprobes can be made to generate radiation that could kill bacteria, viruses and cancer cells. Nanotechnology also theoretically allows the mimicking of natural biological processes, e.g. repair of damaged tissues or acting as artificial red blood cells to transport oxygen.

The global market for healthcare nanotechnology is expected to reach USD 196.02 billion by 2020 growing at a CAGR of 12.1%, according to a new study by Grand View Research, Inc. Increasing susceptibility of patients towards chronic diseases such as cardiovascular, neurological, oncology and respiratory diseases coupled with increasing R&D spending opening new application avenues is expected to drive market growth over the next six years. Other drivers of this market include increasing government and private sector R&D aid and new players entering the market to bridge the gap between supply and demand.

Importance & Scope of Nano Delivery:

View post:Nanodelivery 2018 Conferences | Nanomedicine Meetings

View original post here:

Nano Medicine

Top Nanomedicine Conferences|DrugDelivery meetings …

Posted on June 26, 2018 by Dook Domini

About Us

3rd ,International Conference and Exhibition on Nanomedicine and Drug Delivery March 13-14, 2019 Singapore

Conference Series LLC Ltd is a renowned organization that organizes highly notablePharmaceutical Conferencesthroughout the globe. Currently we are bringing forth3rdInternational Conference on Nanomedicine and Drug Delivery(NanoDelivery 2019) scheduled to be held duringMarch 13-14, 2019 at Singapore. The conferenceinvites all the participants across the globe to attend and share their insights and convey recent developments in the field of Nanomedicine and Drug Delivery.

Conference Series LLC Ltdorganizes 1000+ Global Events inclusive of 1000+ Conferences, 500+ Upcoming and Previous Symposiums and Workshops in USA, Europe & Asia with support from 1000 more scientificsocietiesand publishes 700+Open access Journalswhich contains over 50000 eminent personalities, reputed scientists as editorial board members.

2019 Highlights:

Nanomedicine and Drug Delivery will account for 40% of a $136 billion nanotechnology-enabled drug delivery market by 2021. We forecast the total market size in 2021 to be US$136 billion, with a 60/40 split between Nano medicine and Drug Delivery respectively, although developing new targeted delivery mechanisms may allow more value to be created for companies and entrepreneurs.

However, the Asia-Pacific region is expected to grow at a faster CAGR owing to presence of high unmet healthcare needs, research collaborations and increase in nanomedicine research funding in emerging economies such as Singapore, Japan, China, India and other economies in the region. Singapore is expected to surpass the United States in terms of nanotechnology funding in the near future, which indicates the growth offered by this region.This conference seeks to showcase work in the area of Nanomedicine, Drug Delivery Systems, and nanotechnology, Nanobiothechnology, particularly related to drug delivery.

For More PS:https://nanomedicine.pharmaceuticalconferences.com/

(Click here for any queries)

Nanomedicine and drugdelivery can address one of the greatest challenges in the post-genomic era of the 21st century making the essential connections between Academics and industry professionals.

To meet these challenges, the field of Nanomedicine and drugdelivery has undergone exponential growth during the last 5 years. Technologies such asPersonalized Nanomedicine, Design of Nanodrugs,Synthesis of Nanoparticles for Drug Delivery,Regenerative MedicineandTissue Engineering, Nanomedicines and Biomedical applications,Nanomaterials for drug delivery,Regulatory Aspects Towards Approval of Nanomedicine,NanoPharmaceutical, Industry and Market processing and drug delivery promise to transform the world ofAdvanced nanomedicinesanddrug deliverymuch in the same way that integrated and transformed the world of pharmaceutical sciences.

Nanodelivery 2019 has everything you need:

Open panel discussions: Providing an open forum with experts from academia and business to discuss on current challenges innanomedicineanddrug delivery, where all attendees can interact with the panel followed by a Q&A session.

Speakerandposter presentations: Providing a platform to all academicians and industry professionals to share their research thoughts and findings through a speech or a poster presentation.

Round table meetings: Providing a platform where industry professionals meet academic experts.

Over 50+ organizations and international pavilions will be exhibiting at the Nanodelivery 2018 conference and Exhibition. Exhibitors will include equipment manufacturers and suppliers, systems providers, finance and investment firms, R&D companies, project developers, trade associations, and government agencies.

The Nanodelivery 2019 has everything you need, all under one roof, saving you both time and money. It is the event you cannot afford to miss!

Who's Coming to Nanodelivery 2019?

Conference Keywords

Nanomedicine:

Nanomedicineis the medical application ofnanotechnology, nanomedicineranges from the medical applicationsofnanomaterialsandbiological devices, to nanoelectronicbiosensors, and even possible future applications of molecular nanotechnology such asbiological machines.

Nanomedicine : Future Nanomedicine:

We can say that nanomedicine is ourfuture medicine.The usage ofNanomedicine in drug deliverycan unlock the way to cure many life threatening diseases. For examplesnanomedicine in cancer treatment,Nanomedicine for blood disorders,Nanomedicine for Lung Diseases, Nanomedicine for Cardiovascular Diseases. This includesFuture aspects of Nanomedicine,nanobots,nanodrugs.

Nanomedicine research group:

This is only possible by the grace and smart work of thenanomedicine research groupfrom all over the world.Nanomedicine coursesare taught in theuniversities all over the world.They also providepostdoctoral fellowship opportunity in nanomedicine.So we can say thatfuture of nanomedicineshines brightly .

Nanomedicine Market:

Nanomedicinecan be explained as theapplication ofnanotechnologytoachieveinnovation in healthcare.Theglobal nanomedicine marketis anticipatedto reach USD 350.8 billion by2025.This includes:Scope of Nanomedicine,Novel Drugs to NanoDrugs,Nanodrugs for Herbal medicinesand Cosmetics

Nanomedicine in Cancer:

A wide range of new tools and possibilities is already achieved incancer treatments using Nanotechnology, fromdiagnosingit earlier to improvedimagingfortargeted therapies.This includes Nanomedicine for other disease,Nanomedicine for Cardiovascular Diseases,Nanodrugs for Cancer Therapy

New formulations:

Nanomedicines are three-dimensional constructs of multiple components with preferred spatial arrangements for their functions.This includesNano Sized Drugs,Nanodrugs for Veterinary Therapeutics,Nanodrugs for Medical applications,Formulation and Development.

Emergence of Nanomedicines:

Extensive multidisciplinary investigation in the field ofnanomedicine nanotechnology biology and medicinehas caused the emergence of Nanomedicine as promising carriers fordeliveryof diversetherapeutic moleculesto the targeted sites. This includesNanodrugs for Cancer Therapy,Nanodrugs for Veterinary Therapeutics,Nanodrugs for Medical applications.

VLPs:

VLPsare a viruses devoid ofgenetic materialand thus they cannotreplicate.This includesNanoMedicine in HIV,Drug targeting,Nanomedicine for Cancer.

Nanocarrier :

A nanocarriers are used as atransport modulefor adrug. Commonly usednanocarriersincludemicelles,polymers,carbon-based materials,liposomesandmany more.This includesnanoparticles,nanobots,nanodrugs.

Nanomedicine-History:

It was the extensive multidisciplinary investigation in the field ofnanomedicine nanotechnologybiology and medicinethat gave rise to thefuture medicinei.e.Nanomedicine. We know that nanotechnology is a recent development inscientific research,though the development of its central concepts happened over a longer period of time.This includesNanomedicine for other disease,Nanodrugs for Herbal medicines and Cosmetics

Biomedical nanotechnology:

Biomedical nanotechnologyincludes a diverse collection of disciplines.This includesCarbon Nanotubes,BiosensorsandNanobioelectronics,Nanobiomechanics and Nanomedicine.

Drug delivery systems:

Drug deliveryis theformulations,technologies, and systems for transporting apharmaceutical compoundinside the body safely to achieve itsdesired therapeutic effect.This includesLiposomes,Versatile Polymers In Drug Deivery,Drug Development

Toxicity:

Toxicityis the measure to which a particular mixture of substances can damage an organism.This includeGold Nanoparticles,Silver Nanoparticles,Magnetic Nanoparticles.

Xenobiotics:

Axenobioticis a chemical substances which is not produced naturally or expected to be found within an organism.This includesNano Micro Particles,BiosensorsandNanobioelectronics,Bio inspired materials and drug delivery

Pharmaceutical technology:

We can detect diseases at much earlier stages usingNano pharmaceuticals.Usingnanoparticles we can also design thediagnostic applicationsconventionally.This includesNanoliposome,Drug Targeting,Challenges and advances in NanoPharmaceuticals

Bioimaging:

Bioimagingare methods that non-invasively visualizebiological processesin real time.This includesImage-guided drug delivery,Imaging,Optical sensors

Imaging probe:

Molecular imaging probeis an agent used tovisualize, characterize and quantify biological processes in living systems .This includesOptical sensors,Smart Polymer Nanoparticles,NanomaterialsforImaging

Pharmaceutical compound:

The particular pharmaceutical product to fit the unique need of a patient can be made byPharmaceutical compounding.This includesChallenges and advances in Nano Pharmaceuticals,Nano Pharmaceuticalsfrom thebench to Scale up

Pulmonary delivery:

Pulmonary deliveryofdrughas become an attractive target and of tremendous scientific andbiomedical interestin thehealth care research.This includes Transmucosal Drug Delivery Systems, Sonophoresis Drug Delivery System, Hydrogel in Drug Delivery

Vascular disease:

Diseases of theblood Vessels can be related toVascular diseases.This includesovarian, breast cancer,kidney disease,fungal infections.

Tissue engineering:

The use of a tissue, engineering and materials methods, and suitablebiochemicalandphysicochemical factorsto improve or replacebiological tissues.This includesNeuro Regenerations,Organ fabrication,Cell-based therapies

Regenerative medicine:

Regenerative medicineis a broad field that includes tissue engineering but also incorporates onself-healing

Regenerative medicine- self healing:

Body uses its own systems, sometimes with help foreignbiological materialtorecreate cellsandrebuild tissuesand organs.This includeBiologic scaffolds,Bone Marrow Tissue Engineering,Mechanical properties of engineered tissues

Quantitative Imaging:

Quantitative imagingprovides clinicians with a more accurate picture of a disease state.This includesImage-guided drug delivery,Imaging,Optical sensors.

Tissue Sciences:

The internal organs and connective structures ofvertebrates, andcambium,xylem, andphloemin plants are made up of different types of tissue.This includesNeuro Regenerations,Bioreactor design,Bone Marrow Tissue Engineering.

Rational drug design:

Drug design, is simply the inventive process of findingnew medicationsbased on the knowledge of abiological targetThis includesNanodrugs for Cancer Therapy,Nanodrugs for Medical applications,Nano Sized Drugs

Drug target:

Biological targetcan be described as thenative proteinin the body , with modified activity by a drug resulting in a specific effect. The biological target is often referred to as a drug target.This includeDrug targeting,Image-guided drug delivery,target site

Drug resistance mechanism:

InDrug resistancethe effectiveness of amedicationis reduced such as anantimicrobialor anantineoplasticin curing a disease or condition.This includeschemotherapy,tumor-targeted drug delivery

Single molecule imaging:

Single-molecule studies may be contrasted with measurements on the bulk collection of molecules. In this individual behavior ofmoleculescannot be distinguished, and only average characteristics can be measured.This includeDrug targeting,Image-guided drug delivery,Imaging

Medicine:

Medicine can be explained as the science and practice of thediagnosis,treatment, andprevention of disease.This include Controledradical polymerization,Nanodrugs for Herbal medicinesandCosmetics,Nanomedicine for Gastrointestinal Tract (GI) Diseases.

Computer-Aided Diagnosis:

Computer-aided detection(CADe), are systems that help doctors in the interpretation ofmedical images.This includesImage-guided drug delivery,Optical sensors,BiosensorsandNanobioelectronics

Pharmacology:

Pharmacology is the study ofdrug action, where a drug can be broadly defined as any man-made, natural, or endogenousThis includesNanoliposome,Drug Targeting,Applied biopharmaceutics

Drug delivery industries:

Demand fordrug deliveryproducts in the US will rise 6.1 percent yearly to $251 billion in 2019. Parenteral products will grow the fastest, driven bymonoclonal antibodiesandpolymer-encapsulated medicines.Hormonesand central nervous system agents will lead gains by application.Pen injectorsand retractable prefillable syringes will pace devices.This includesBio Pharmaceutical Industry,Focus on Nanopharmaceuticals,Industrial Applications of Nano medicine.

Drug delivery market:

The drug delivery market is thelargest contributing applicationsegment, whereasbiomaterialsis the fastest growing application area in this market. Nanomedicine accounts for 77Marketed ProductsWorldwide, representing an Industry with an estimated market $130.9 Billion by 2016.This includesBio Pharmaceutical Industry,Focus on Nanopharmaceuticals,Industrial Applications of Nano medicine.

Nanomedicine Market Size:

Theglobal nanomedicine marketis anticipated to reach USD 350.8 billion by 2025, according to a new report by Grand View Research, Inc. Development ofnovel nanotechnology-based drugsandtherapiesis driven by the need to develop therapies that have fewer side effects and that are morecost-effectivethantraditional therapies, in particular for cancer.This includespharmaceutical industry,Up Coming Market for Nanotechnology,Focus on Nanopharmaceuticals.

Biodegradable implants:

Biodegradable implants offer a number of financial,psychological, andclinical advantagesoverpermanent metal implants.They provide the appropriate amount of mechanical strength when necessary, and degrade at a rate similar tonew tissue formation, thereby transferring the load safely to thehealed boneand eliminating the need for an additional revision and removal operation.This includesBiologic scaffolds,Biomaterials,Bone Marrow Tissue Engineering.

Nanomedicine industry:

Expecteddevelopments in nanoroboticsowing to therise in fundingfrom thegovernment organizationsis expected to induce potential to the market.Nanorobotics engineering projectsthat are attempting totarget the cancer cellswithout affecting the surrounding tissues is anticipated to drive progress through to 2025.This includesIndustrial Applications of Nano medicine,Nanotechnology tools in Pharmaceutical R&D,Bio Pharmaceutical Industry,Focus on Nanopharmaceuticals

Nanomedicine Market Drivers:

The major drivers of the nanomedicine market include its application in varioustherapeutic areas, increasingR&D studiesabout nanorobots in this segment, andsignificant investmentsinclinical trialsby the government as well as private sector. TheOncology segmentis the majortherapeutic areafornanomedicine application, which comprised more than 35% of the total market share in 2016.This includesAn Up and Coming Market for Nanotechnology,Nanomedicine: Prospects, Risks and Regulatory Issues,Current , Future Applications and Regulatory challenges.

Nanomedicine Market trends:

Thetherapeutic areas for nanomedicineapplication areOncology,is includesCurrent , Future Applications and Regulatory challenges,Regulatory Policies.

Read the original:

Top Nanomedicine Conferences|DrugDelivery meetings ...

Nanomedicine – Overview

Posted on May 13, 2018 by jessica

The program began in 2005 with a national network ofeight Nanomedicine Development Centers. Now, in the second half of this 10-year program, the four centers best positioned to effectively apply their findings to translational studies were selected to continue receiving support.

Nanomedicine, an offshoot of nanotechnology, refers to highly specific medical intervention at the molecular scale for curing disease or repairing damaged tissues, such as bone, muscle, or nerve. A nanometer is one-billionth of a meter, too small to be seen with a conventional lab microscope. It is at this size scale about 100 nanometers or less that biological molecules and structures operate in living cells.

The NIH vision for Nanomedicine is built upon the strengths of NIH funded researchers in probing and understanding the biological, biochemical and biophysical mechanisms of living tissues. Since the cellular machinery operates at the nanoscale, the primary goal of the program - characterizing the molecular components inside cells at a level of precision that leads to re-engineering intracellular complexes - is a monumental challenge.

The teams selected to carry out this initiative consist of researchers with deep knowledge of biology and physiology, physics, chemistry, math and computation, engineering, and clinical medicine. The choice and design of experimental approaches are directed by the need to solve clinical problems (e.g., treatment of sickle cell disease, blindness, cancer, and Huntingtons disease). These are very challenging problems, and great breakthroughs are needed to achieve the goals within the projected 10 year timeframe. The initiative was selected for the NIH Roadmap (now Common Fund) precisely because of the challenging, high risk goals, and the NIH team is working closely with the funded investigators to use the funds and the intellectual resources of the network of investigators to meet those challenges.

10 Year Program Design High Risk, High Reward

The Centers were funded with the expectation that the first half of the initiative would be more heavily focused on basic science with increased emphasis on application of this knowledge in the second five years. This was a novel, experimental approach to translational medicine that began by funding basic scientists interested in gaining a deep understanding of an intracellular nanoscale system and necessitated collaboration with clinicians from the outset in order to properly position work at the centers so that during the second half of the initiative, studies would be applied directly to medical applications. The program began witheight Nanomedicine Development Centers(NDCs), and four centers remain in the second half of the program.

Clinical Consulting Boards (CCBs)

The program has establishedClinical Consulting Boards (CCBs)for each of the continuing centers. These boards consist of at least three disease-specific clinician-scientists who are experts in the target disease(s). The intent is for CCBs to provide advice and insight into the needs and barriers regarding resource and personnel allocations as well as scientific advice as needed to help the centers reach their translational goals. Each CCB reports directly to the NIH project team.

Translational Path

In 2011, the PIs of the NDCs worked with their CCBs to precisely define their translational goals and the translational research path needed to reach those goals by the end of the initiative in 2015. To facilitate this, the NIH project team asked them to developcritical decision pointsalong their path. These critical decision points differ from distinct milestones because they may be adjusted based on successes, challenges, barriers, and progress. Similarly, the timing of these decision points may be revised as the centers progress. Research progress and critical decision points are revisited several times a year by the CCB and the NIH team, and when a decision point is reached, next steps are re-examined for relevance, feasibility and timing.

Transition plan

Throughout the program, various projects have been spun off of work at all the centers and most have received funding from other sources. This was by design as work at each center has been shifting from basic science to translational studies. Centers will not be supported by the common fund after 10 years. It is expected that work at the centers will be more appropriately funded by other sources. Pre-clinical targets will likely be developed, and the work at each center will be focused on a specific disease so the work will need to transition out of the experimental space of the common fund.

Support for the NIH Nanomedicine Initiative is provided by the NIH Common Fund, and a team of staff members from across the NIH oversees the program. You may direct questions or comments on the NIH Nanomedicine Initiative to Dr. Richard S. Fisher, Nanomedicine Project Team Leader (nano@nih.gov).

See original here:

Nanomedicine - Overview

Regenerative Nanomedicine Lab – yimlab.com

Posted on April 28, 2018 by Dook Domini

Our recent research article "In-vitro Topographical Model of Fuchs Dystrophy for Evaluation of Corneal Endothelial Cell Monolayer Formation" appeared on theBack cover of Advanced Healthcare Materials latest issue.

Several diseases have been known to be caused by microstructural changes in the extracellular microenvironment. Therefore, the knowledge of the interaction of cells with the altered extracellular micro-structures or surface topography is critical to develop a better understanding of the disease for therapeutic development. One such disease is Fuchs corneal endothelial dystrophy (FED). FED is the primary disease and major reason of corneal endothelial cell death. If left untreated, corneal blindness will be resulted; thus, FED is the leading indication for corneal transplantation. In the USA, 4% of population over the age of 40 is believed to have compromised corneal endothelium due to FED, which will further increase due to increasing life expectancy and rapidly ageing population. A diagnostic clinical hallmark of FED is the development of discrete pillar or dome-like microstructures on the corneal endothelial basement membrane (Descemet membrane). These microstructures are called corneal guttata or guttae. Cell therapies have been proposed as an alternative treatment method for Fuchs dystrophy patients. However, currently, no in-vitro or in-vivo FED disease model is available to study the cell therapies before clinical trials.

In this study, the pathological changes in the micro-structure of basement membranes resulting from FED disease was analyzed, to identify geometrical dimension to develop an in-vitro disease model of synthetic corneal guttata pillars/domes by using microfabrication techniques. This model was used to study the monolayer formation of donor-derived human corneal endothelial cells to test the effectiveness of the corneal endothelial cell regenerative therapies. The results suggest that the corneal cell therapies may not be equally effective for patients at different stages of disease progression. The pre-existing guttata in patients could interfere with the cells thus hampering monolayer formation within the eye. Surgical removal of the guttata from the diseased Descemet membrane prior to cell regenerative therapy could increase the success rate of monolayer formation, which could potentially increase the chances of cell therapy success. This study also demonstrate how biomaterial design can be employed to mimic the pathological microstructural changes in basement membranes for better understanding of cellular responses in disease conditions.

See the original post here:

Regenerative Nanomedicine Lab - yimlab.com

Web Hosting Services – Northeastern ITS

Posted on April 28, 2018 by Dook Domini

ITS offers web hosting solutions for university members who wish to create university-connected websites. This includes a http://www.northeastern.edu/____ site hosted on the NUWeb servers.

Web hosting is available for all full-time faculty and staff, as well as student groups with an advisor. Requests for new space and access, or additional features on existing sites, are made through the Webpage Requests section of the ServiceNow portal (sign-in may be required).

All NUWeb accounts have one administrative contact who must be a current Northeastern faculty or staff member.

Accounts will expire after one year all accounts are up for renewal every September. Submit a NUWeb Account renewal request through the ServiceNow portal (sign-in may be required).

To request a new account including space on the NUWeb server and a custom URL you will need to submit a NUWeb New account request through the ServiceNow portal (sign-in may be required).

This request will include an option to have a WordPress installation.

As someone with access to the Northeastern NUWeb server, you are expected to comply with a number of security, privacy and appropriate use terms as outlined in the links below:

For more information on the web hosting solutions, look through the FAQs and HOW TO sections linked below. For technical assistance with or questions about a live site, fill out Report a problem with an NUWeb Account through the ServiceNow portal (sign-in may be required).

You can also find a number of WordPress tips and tricks in the Lynda.com playlist that ITS Training has created. Click on this link, and sign in with your myNortheastern username and password to access the video courses.

Web Hosting FAQ

Web Hosting How To

Web Hosting Services - Northeastern ITS

Regenerative Nanomedicine Lab

Posted on March 4, 2018 by jessica

Read the original here:

Regenerative Nanomedicine Lab

Euroscicon – Nanotech & Nanobiotechnology

Posted on February 23, 2018 by ev1

About Conference

The EuroSciCon will be holding conference onNanotech & Nanobiotechnology 2018 which is scheduled duringJuly 12-13, 2018atParis, France. The theme of the conference isChallenges and Innovations in next generation Nanoscience".

The Nanobiotech 2018 aims to bring together leading academic scientists, researchers and research scholars to exchange and share their experiences and research results about all aspects of Nanomedicine in Healthcare. It also provides the premier interdisciplinary forum for researchers, practitioners and educators to present and discuss the most recent innovations, trends, and concerns, practical challenges encountered, and the solutions adopted in the field of Nanomedicine. The conference program will cover a wide variety of topics relevant to the Nanomedicine, including: Nanomedicine in drug discover and delivery, Nano diagnostics, theragnostic, applications of Nanomedicine in healthcare applications and disease treatments.

What's New

Nanotech & Nanobiotechnology 2018 includes international attendee workshops, lectures and symposia, including a designated registration area, a refreshment break and gala lunch. Nanotechnology educators can join the EuroSciCon as an international member to receive discounts on registration. So, come and join leading experts and allied professionals from July 12-13, 2018 in Paris, France to keep up with the rapidly accelerating pace of change that is already having an impact on the field of Nanotechnology, Nanomedicine & Nanobiotechnology and will continue to in the future. The field ofNanotechnologyhave not only helped the development in different fields in science and technology but also contributed towards the improvement of the quality of human life to a great extent. All this has become possible with the different discoveries and inventions leading to the development of various applications. The core aim of Nanotech & Nanobiotechnology 2018conference is to provide an opportunity for the delegates to meet, interact and exchange new ideas in the various areas of Nanotechnology andBiotechnology.

About Paris, France

Paris is the capital and most populous city of France. The city is both acommuneanddepartmentand forms the Centre and headquarters of theFrance, or Paris Region. By the 17th century, Paris was one of Europe's major centers of finance, commerce, fashion, science, and the arts, and it retains that position still today. The Paris Region had aGDPof 624 billion (US $687 billion) in 2012, accounting for 30.0 percent of the GDP of France. Paris is often referred to as "The City of Light" (La Ville Lumire), both because of its leading role during the Age of Enlightenment , and more literally because Paris was one of the first European cities to adopt gasstreet lighting. In the 1860s, the boulevards and streets of Paris were illuminated by 56,000 gas lamps. Since the late 19th century, Paris has also been known asPan-am.

Paris has many important cultural institutions: itsLouvremuseum is the most visited in the world; itsMuse d'Orsayis noted for its collection of FrenchImpressionistart, and its Pompidou-centerMuse National d'Art Modernehas the largest collection of modern and contemporary art in Europe. The central area of the city along the Seine River is classified as aUNESCO Heritage Siteand includes many notable monuments, includingNotre Dame Cathedral, theSainte-Chapelle, the formerUniversal ExpositionGrand Palais,Petit PalaisandEiffel Tower, and theBasilica of Sacr-CurinMontmartre. In 2015, Paris received 22.2 million visitors, making it one of the world's top tourist destinations.

Nanomedicine:

ToxicologyNanomedicineis a field of medical science whose applications are increasing more and more thanks tonanorobotsandbiological machines, which constitute a very useful tool to develop this area of knowledge. In the past years, researchers have done many improvements in the different devices and systems required to develop nanorobots. This supposes a new way of treating and dealing with diseases such as cancer; thanks to nanorobots, side effects of chemotherapy have been controlled, reduced and even eliminated, so some years from now, cancer patients will be offered an alternative to treat this disease instead of chemotherapy, which causes secondary effects such as hair loss, fatigue or nausea killing not only cancerous cells but also the healthy ones.

Nanoelectronics:

Nanoelectronics are based on the application of nanotechnology in the field of electronics and electronic components. Although the term Nanoelectronics may generally mean all the electronic components, special attention is given in the case of transistors. These transistors have a size lesser than 100 nanometers. Visibly, they are very small that separate studies must be made for knowing the quantum mechanical properties and inter-atomic design. As a result, though the transistors appear in the nanometer range, they are designed through nanotechnology. Their design is also very much different from the traditional transistors and usually falls in the category of one dimensional nanotubes/nanowires, hybrid molecular electronics, or advanced molecular electronics. This technology is said to be the next future, but its practicality is near to impossible even now that they may be difficult to emerge soon.

Nano architectonics:

The time for a major paradigm shift from nanotechnology to Nano architectonics has come. Scientists in nanoscience and nanotechnology have been creating fine nanomaterials and Nano systems using advanced physical techniques and apparatus, mainly as separate processes. These involve the fabrication of small objects and the observation of their behaviors. However, we are now must construct fine systems from these nanocomponents like the way that carpenters architect house and buildings. Technological efforts at the nanoscale must be organized and converted into the new concept of Nano architectonics

Nanophysics:

Nanotechnology is all about designing, fabricating and controlling materials and components with dimensions on the nanoscale, i.e. from 1 to 100 nm. During the Master's programme in Nanomaterials and Nanophysics you will learn how nanotechnology can be used in order to develop new optic and electronic components and new materials for use in communications technology, sensor technology or catalysis.

Nano mechanics:

The Nano mechanics investigates mechanical properties of engineered and biological materials at the Nano to macro-scale using experimental, analytical, and computational techniques. MEMS/NEMS (Microelectromechanical system/ Nanoelectromechanical system) devices are sensitive to a wide range of stimuli such as temperature, mass, pressure and are thus extensively used as sensors in cars and mobile phones. The biggest promise of MEMS and NEMS technology is the development of extremely small sensor systems that can be used virtually everywhere and thus can impart intelligence to almost all man-made things.

Nanorobotics:

A nanorobotics is a machine that can build and manipulate things precisely at an atomic level. Imaging a robot that can pluck, pick and place atoms like a kid plays with LEGO bricks, able to build anything from basic atomic building blocks. While some people dismiss the future of nanorobots as science fiction, you should realize that each of us is alive today because of countless nanobots operating within each of our trillions of cells. We give them biological names like a ribosome, but they are essentially machines programmed with a function like read messenger RNA to create a specific protein.

Nano chemistry:

Nano chemistry, described the field as "an emerging subdiscipline of solid-state chemistry that emphasizes the synthesis rather than the engineering aspects of preparing little pieces of matter with nanometer sizes in one, two or three dimensions. The Nano chemist can be considered to work towards this goal from the atom 'up', whereas the nanophysics tends to operate from the bulk 'down'." Today, Nano chemists work in biomedical chemistry, polymer chemistry, product synthesis, and a host of other areas. They use a wide variety of methods to prepare and assemble "little pieces of matter" with novel electronic, magnetic, optical, chemical, and mechanical behaviors that can be attributed to their nanometer-scale size.

Nanomaterials:

Nanotechnologies make use of very small objects or artifacts. Nanomaterials are an increasingly important product of nanotechnologies. They contain nanoparticles, smaller than 100 nanometers in at least one dimension. Nanomaterials are coming into use in healthcare, electronics, cosmetics and other areas. Their physical and chemical properties often they differ from those of bulk materials, so they call for specialized risk assessment. This needs to cover health risks to workers and consumers, and potential risks to the environment.

Cellular and subcellular Nanotechnology:

Cell biology today is on the verge of a nanotechnology-driven research era, one in which the availability of sophisticated new experimental techniques and tools of nanotechnology is set not only to emulate more complex,in vivolike extracellular environments, but also monitor dynamic complex biological processes in real time at the single cell level. Ultimately, the goal is to establish a fully integrated knowledge of how the building blocks of humans cells work at the molecular level. It is only by a detailed knowledge of how cells work, independently and together, in healthy and diseased states that one will be able to understand and anticipate the onset and effects of disease and create an appropriate and effective means to prevent and treat disease. The unravelling of cellular and molecular mechanisms that could be used to reprogram or instruct cells would enable unprecedented advances in tissue engineering and regenerative medicine.

Major Challenges in Nanobiotechnology:

Nanotechnology supporters believe that it has the potential to transform our lives dramatically, while opponents of nanotechnology fear that self-replicating "nanobots" could escape from laboratories and reduce all life on earth. Some ethical discussions have been focused on the field of molecular nanotechnology. The lack of meritorious ethics research proposals may be related to the difficulty in identifying or anticipating ethical issues that are unique to nanobiotechnology, particularly its near-term applications.

Advancement in Nanotechnology:

Advanced Nanotechnology was founded by industry visionaries to revolutionize systems and delivers a quantum improvement in performance, dramatically reduce power consumption and deliver extreme security. They use patented hardware and proprietary state-of-the-art algorithms to dramatically increases defense against hacking. We leverage the power of 3D & nanotechnology to break the semiconductor interconnect bottleneck and eliminate the gridlock that limits performance and waste power.

View original post here:

Euroscicon - Nanotech & Nanobiotechnology

Growth in the Global Nanomedicine Market 2017-2021 trends … – satPRnews (press release)

Posted on August 25, 2017 by Dook Domini

Global Nanomedicine Market 2017-2021

This Nanomedicine market research is an intelligence report with meticulous efforts undertaken to study the right and valuable information. The data which has been looked upon is done considering both, the existing top players and the upcoming competitors. Business strategies of the key players and the new entering market industries are studied in detail. Well explained SWOT analysis, revenue share and contact information are shared in this report analysis.

Download sample pages of this report:http://tinyurl.com/y7bs9wea

Data integration and capabilities are analyzed to support the findings and study the predicted geographical segmentations. Various key variables and regression models were considered to calculate the trajectory of Nanomedicine market. Detailed analysis is explained and given importance to with best working models.

Geographically, the segmentation is done into several key regions like North America, Middle East & Africa, Asia Pacific, Europe and Latin America. The production, consumption, revenue, shares in mill UDS, growth rate of Nanomedicine market during the forecast period of 2017 to 2021 is well explained.

The ongoing market trends of Nanomedicine market and the key factors impacting the growth prospects are elucidated. With increase in the trend, the factors affecting the trend are mentioned with perfect reasons. Top manufactures, price, revenue, market share are explained to give a depth of idea on the competitive side.

Each and every segment type and their sub types are well elaborated to give a better idea about this market during the forecast period of 2017 to 2021 respectively.

Download sample pages of this report:http://tinyurl.com/y7bs9wea

About Us: Key Market Insights is a stand-alone organization with a solid history of advancing and exchanging market research reports and logical surveys delivered by our numerous transnational accomplices, which incorporate both huge multinationals and littler, more expert concerns.

Contact:

Mr. Mannansales@kminsights.com +1 (888) 278-7681

New report shares details about Europe’s nanomedicine market – WhaTech

Posted on August 25, 2017 by Dook Domini

The global nanomedicine market size was estimated at USD XX billion in 2017. Technological advancements coupled with relevant applications in early disease diagnosis, preventive intervention, and prophylaxis of chronic as well as acute disorders is expected to bolster growth in this market.

Nanotechnology involves the miniaturization of larger structures and chemicals at nanometric scale which has significantly revolutionized drug administration, thus influencing adoption of the technology through to 2022.

Download Sample Pages @www.kminsights.com/request-sample-33081

Ability of the nanotechnology to serve in diagnostics as well as the therapeutic sector at the same time as a consequence of its characteristic principle to is anticipated to augment research in this sector. Furthermore, utilization of DNA origami for healthcare applications is attributive for the projected growth.

The global nanomedicine market is segmented based on modality, application, indication, and region. Based on application, it is classified into drug delivery, diagnostic imaging, vaccines, regenerative medicine, implants, and others.

On the basis of indication, it is categorized into oncological diseases, neurological diseases, urological diseases, infectious diseases, ophthalmological diseases, orthopedic disorders, immunological diseases, cardiovascular diseases, and others. Based on modality, it is bifurcated into treatments and diagnostics.

This report studies sales (consumption) of Nanomedicine in Europe market, especially in Germany, UK, France, Russia, Italy, Benelux and Spain, focuses on top players in these countries, with sales, price, revenue and market share for each player in these Countries, the top player covering Affilogic LTFN Bergmannstrost Grupo Praxis Biotechrabbit Bracco Materials Research?Centre Carlina technologies ChemConnection CIC biomaGUNE CIBER-BBN Contipro Cristal Therapeutics DTI Endomagnetics Fraunhofer ICT-IMM Tecnalia Tekniker GIMAC IMDEA Istec CNR SwedNanoTech Vicomtech VITO NV

The global market is driven by emerging technologies for drug delivery, increase in adoption of nanomedicine across varied applications, rise in government support & funding, growth in need for therapies with fewer side effects, and cost-effectiveness of therapies. However, long approval process and risks associated with nanomedicine (environmental impacts) restrain the market growth.

In addition, increase in out-licensing of nanodrugs and growth of healthcare facilities in emerging economies are anticipated to provide numerous opportunities for the market growth.

Download Sample Pages @www.kminsights.com/request-sample-33081

Excerpt from:

New report shares details about Europe's nanomedicine market - WhaTech

Are nano drug delivery and telehealth solutions a deadly combo for disease? – EPM Magazine

Posted on August 24, 2017 by Dook Domini

by Alexander Myskiw DataArt

23 August 2017

10:16

Incorporating telehealth solutions into new drug delivery technologies like nanomedicines can potentially give pharmaceuticals the edge they need to win the fight against disease.

Creating drug delivery systems that utilise telehealth solutions like smartphone technologies, Bluetooth, IoT, wearable technologies, and AI would help pharmaceutical companies save money in clinical trials by reducing the financial burden caused by poor medical adherence and provide better patient outcomes through real-time data analysis. Telehealth solutions provide physicians and clinical trial scientists direct access to their patient, and can provide them with valuable data that will improve their performance and the patients health. Access to real-time patient health data is an opportunity for pharmaceutical companies to develop a range of smart drug delivery systems that could potentially change the way an estimated 50% of the population deal with their chronic diseases.

With large numbers living with some form of chronic disease, pharmaceutical companies must incorporate telehealth tech into their drug delivery systems to collect real-time data and use the data to improve patient treatment, clinical trial outcomes and apply the data for further research.

The drug delivery systems available in todays market are honestly not that impressive. A Bluetooth-enabled inhaler, smart automatic injectors, and smart pills are definitely technologies that benefit patient care but lack innovative pizzazz. Bluetooth technology was first introduced in mobile phones in 2000. It has taken 17 years to implement the data-gathering technology into an inhaler/auto injector, often at times requiring user actions like downloading from an SD card. I am surprised it has taken this long for pharma to get where it is today, but there is truly hope on the horizon, with recent advancements in nanotechnology.

The future of pharmaceuticals and population health lies in the utilisation of telehealth solutions like the Internet of Nano Things (IoNT), wearables, smartphones and the latest drug delivery tech likesmart nanoplatforms, nanoparticles/nanomedicines, and nanosensors. These recent technological advancements in drug delivery should change the way we understand and cure diseases.

Northwestern University has developed a nanoplatform that can assess the effectiveness of nanomaterials in regulating gene expression. The nanoplatform allows scientists to observe nanomedicines and particle behaviour in an in vivo setting. Theres no doubt that the relationship between nanomedicines and IoNT is inevitable however there are issues like patient health risks and security that must be taken into account.

Whenever the internet is involved, the issue of security should be raised. Are nanomedicines saving patients lives, while also putting them at risk of body hacking? Although programmable particles are sending signals from within the patients body and providing beneficial information for the doctor/scientist, the idea that a signal can be hacked is a horrific reality. Nanoparticle manipulation is possible by gaining access to the particles using ultrasound and electromagnetic field waves making hacking feasible but extremely difficult and complex. The next question is what happens to the nanoparticles after treatment? Will they pose a later threat and become an access point for hackers?

Nanomedicines, after entering the human body, travel throughout reaching the organs, the bloodstream, the lungs and even crossing the semi-permeable membranes into cells delivering the drugs to exactly the right place at the right time. Their disbursement depends on size and programming. Nanoparticles are metal-based, carbon-based, composites, and dendrimers, and are excreted from the body via faeces and urine. The liver and spleen can also decompose them, however up to 30% can remain in the body for an extended period of time and potentially become an access point for hacking.

Combining telehealth solutions and nanomedicines will benefit the populations health by presenting effective treatments for chronic and deadly pathologies and provide scientists and doctors previously unattainable data for analysis. This previously elusive data has become available thanks to Northwestern Universitys Nanoplatform, which successfully provides imaging of the nanomedicines effectiveness on the MGMT gene, a chemo-resistant cancer gene. This data has already provided a better understanding of the nanomedicines mechanics and provided researchers with the best time, after treatment with nanomedicines, to administer chemotherapy.

Nanoparticles appear to be a solution that can improve the health of the population, however there are still potential risks for patients. Although most nanoparticles are tested in labs and in vitro, a few potential health risks have been observed. Risks like the creation of a protein corona (a shifting population of different molecules) can influence the immune defence system and mistakenly allow the corona to penetrate good non-targeted tissues. The clumping of protein molecules can also be linked to multiple pathologies, including amyloidosis. Some nanoparticles have also been linked to genetic mutations, DNA damage, and chromosomal alterations, however they are rarely attributed to all three at once. It is quite clear that more research and testing is required to truly understand the future of nanomedicine and its effects on the human body.

Nanomedicines target a specific area within the body, can delay activation and have the potential to relay real-time data for analysis. Scientists and doctors can finally have a real-time view of their treatments and understand the pathology and its interaction with the medicines, leading to data that will help the healthcare industry save lives, defeat disease, and save money. The benefits in combining telehealth solutions with nano drug delivery systems is evident and it is the colossal leap forward that the industry has been looking for in the never-ending fight with diseases like cancer.

by Alexander Myskiw DataArt

23 August 2017

10:16

View original post here:

Are nano drug delivery and telehealth solutions a deadly combo for disease? - EPM Magazine

Nanomedicinal products: a survey on specific toxicity and side effects – Dove Medical Press

Posted on August 22, 2017 by Dook Domini

Walter Brand,1,* Cornelle W Noorlander,1,* Christina Giannakou,2,3 Wim H De Jong,2 Myrna W Kooi,1 Margriet VDZ Park,2 Rob J Vandebriel,2 Irene EM Bosselaers,4 Joep HG Scholl,5 Robert E Geertsma2

1Centre for Safety of Substances and Products, 2Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, 3Department of Toxicogenomics, Maastricht University, Maastricht, 4Section Pharmacology, Toxicology and Pharmacokinetics, Medicines Evaluation Board (CBG-MEB), Utrecht, 5Research & Analysis Department, Netherlands Pharmacovigilance Centre Lareb, s-Hertogenbosch, the Netherlands

*These authors contributed equally tothis work

Abstract: Due to their specific properties and pharmacokinetics, nanomedicinal products (NMPs) may present different toxicity and side effects compared to non-nanoformulated, conventional medicines. To facilitate the safety assessment of NMPs, we aimed to gain insight into toxic effects specific for NMPs by systematically analyzing the available toxicity data on approved NMPs in the European Union. In addition, by comparing five sets of products with the same active pharmaceutical ingredient (API) in a conventional formulation versus a nanoformulation, we aimed to identify any side effects specific for the nano aspect of NMPs. The objective was to investigate whether specific toxicity could be related to certain structural types of NMPs and whether a nanoformulation of an API altered the nature of side effects of the product in humans compared to a conventional formulation. The survey of toxicity data did not reveal nanospecific toxicity that could be related to certain types of structures of NMPs, other than those reported previously in relation to accumulation of iron nanoparticles (NPs). However, given the limited data for some of the product groups or toxicological end points in the analysis, conclusions with regard to (a lack of) potential nanomedicine-specific effects need to be considered carefully. Results from the comparison of side effects of five sets of drugs (mainly liposomes and/or cytostatics) confirmed the induction of pseudo-allergic responses associated with specific NMPs in the literature, in addition to the side effects common to both nanoformulations and regular formulations, eg, with liposomal doxorubicin, and possibly liposomal daunorubicin. Based on the available data, immunotoxicological effects of certain NMPs cannot be excluded, and we conclude that this end point requires further attention.

Keywords: adverse effects, drug safety, immunotoxicity, nanomedicine, nanotoxicology, pharmacovigilance

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Visit link:

Nanomedicinal products: a survey on specific toxicity and side effects - Dove Medical Press

Growth in Nanomedicine market-2017 trends, forecasts, analysis – satPRnews (press release)

Posted on August 18, 2017 by Dook Domini

The report firstly introduced the Nanomedicine basics: definitions, classifications, applications and industry chain overview; industry policies and plans; product specifications; manufacturing processes; cost structures and so on. Then it analyzed the worlds main region market conditions, including the product price, profit, capacity, production, capacity utilization, supply, demand and industry growth rate etc. In the end, the report introduced new project SWOT analysis, investment feasibility analysis, and investment return analysis.

Download sample pages of this report: http://www.kminsights.com/request-sample-1892

Nanomedicine is a branch of medicine that applies the knowledge and tools of nanotechnology to the prevention and treatment of disease. Nanomedicine involves the use of nanoscale materials, such as biocompatible nanoparticles and nanorobots, for diagnosis, delivery, sensing or actuation purposes in a living organism.

Each and every segment type and their sub types are well elaborated to give a better idea about this market during the forecast period of 2017respectively.

Download sample pages of this report: http://www.kminsights.com/request-sample-1892

Contact: sales@kminsights.com +1 (888) 278-7681

Originally posted here:

Growth in Nanomedicine market-2017 trends, forecasts, analysis - satPRnews (press release)

Targeting tumours: IBBME researchers investigate biological barriers to nanomedicine delivery – U of T Engineering News

Posted on August 9, 2017 by Dook Domini

For cancer patients, understanding the odds of a treatments success can be bewildering. The same drug, applied to the same type of cancer, might be fully successful on one persons tumour and do nothing for another one. Physicians are often unable to explain why.

Now, U of T Engineering researchers are beginning to understand one of the reasons.Abdullah Syed and Shrey Sindhwani, both PhD candidates,and their colleagues at the Institute of Biomaterials & Biomedical Engineering (IBBME) have created a technology to watch nanoparticles traveling into tumours revealing barriers that prevent their delivery to targets and the variability between cancers.

The biggest thing weve noticed is that nanoparticles face multiple challenges posed by the tumour itself on their way to cancer cells, says Sindhwani, an MD-PhD student in the Integrated Nanotechnology & Biomedical Sciences Laboratory of Professor Warren Chan (IBBME). Syed and Sindhwani co-published their findings online June 22, and on the cover of the Journal of the American Chemical Society. So the treatment might work for a while or worse, theres just enough of the drug for the cancer to develop resistance. This could be prevented if we can figure out the ways in which these barriers stop delivery and distribution of the drug throughout the cancer.

Tiny nanoparticles offer great hope for the treatment of cancer and other disease because of their potential to deliver drugs to targeted areas in the body, allowing more precise treatments with fewer side effects. But so far the technology hasnt lived up to its promise, due to delivery and penetration problems.

To dismantle this roadblock, the two graduate students searched for a way to better view the particles journey inside tumours. They discovered that the tough-to-see particles could be illuminated by scattering light off their surfaces.

The sensitivity of our imaging is about 1.4 millionfold higher, says Syed. First, we make the tissue transparent, then we use the signal coming from the particles to locate them. We shine a light on the particles and it scatters the light. We capture this scattering light to learn the precise location of the nanoparticles.

It was already understood that nanoparticles were failing to accumulate in tumours, thanks to a meta-analysis of the field done by Chans group. But the researchers have developed technologies to look at nanoparticle distribution in 3D, which provides a much fuller picture of how the particles are interacting with the rest of the tumour biology. The goal is to use this technology to gather knowledge for developing mathematical principles of nanoparticle distribution in cancer, similar to the way principles exist for understanding the function of the heart, says Syed.

And because each tumour is unique, this technology and knowledge base should help future scientists to understand the barriers to drug delivery on a personalized basis, and to develop custom treatments.

The next step is to understand what in cancers biology stops particles from fully penetrating tumours and then to develop ways to bypass cancers defences.

But the technology is also useful for diseases other than cancer. With the help of Professor Jennifer Gommerman, an researcher in the Department of Immunology who studies multiple sclerosis (MS), Syed and Sindhwani captured 3D images of lesions in a mouse model mimicking MS using nanoparticles.

This is going to be very valuable to anyone trying to understand disease or the organ system more deeply, says Sindhwani. And once we understand barriers that dont allow drugs to reach their disease site, we can start knocking them down and improving patient health adds Syed.

Original post:

Targeting tumours: IBBME researchers investigate biological barriers to nanomedicine delivery - U of T Engineering News

Medication for the unborn baby – Medical Xpress

Posted on August 9, 2017 by Dook Domini

August 8, 2017 Empas multicellular model, which is mimicking the placental barrier: a core of connective tissue cells, surrounded by trophoblast cells. Credit: Empa

An Empa team has succeeded in developing a new three-dimensional cell model of the human placental barrier. The "model organ" can quickly and reliably deliver new information on the intake of substances, such as nano-particles, by the placental barrier and on any possible toxic effects for the unborn child. This knowledge can also be used in the future for the development of new approaches to therapy during pregnancy.

During its development, the foetus is extremely susceptible to toxic substances. Even the tiniest doses can cause serious damage. In order to protect the unborn child,one of the tasks of the placenta is to act as a barrier to "filter out" harmful substances, while at the same time providing the foetus with the nutrients it needs. In recent years, however, evidence has increasingly suggested that the placental barrier is not 100 percent effective and that nano-particles are actually able to penetrate it.

Nano-particles are being used in ever more varied areas of our lives. They are used, for example, in sun creams to protect against sunburn; they are used in condiments to stop them getting lumpy; they are used to make outdoor clothing waterproof and they are likely to be used in the future to transport medicines to their rightful destinations in the body . "At the moment, pregnant women are not being exposed to problematic amounts of nano-particles, but in the future that could well happen due to the ever increasing use of these tiny particles," suggests Tina Buerki of the "Department of Particles-Biology Interactions."

In order to ensure the safe development of nano-particles in the most diverse areas of application, their absorption mechanism at the placental barrier and their effect on the mother, foetus and placenta itself must be looked at more closely. It is the size, charge, chemical composition and shape of the nano-particles that could have an influence on whether they actually penetrate the placental barrier and, if so, in what way they are able to do so. At the moment, however, this research is only in its infancy. Since the function and structure of the human placenta is unique, studies undertaken on pregnant mammals are problematic and often inconclusive. Traditional models of the human placental barrier are either very time consuming to construct, or are extremely simplified.

A 3-D model of the human placental barrier

Tests of this nature are best carried out on donated placentas that become available after childbirth by Caesarean section. The organs are connected as quickly as possible to a perfusion system and this ensures the tissue is provided with nutrients and oxygen. This model is, indeed, the most accurate, i.e. the most clinically relevant. It is, however, very technically demanding and, moreover,restricted to a perfusion time window of six to eight hours. Against that, such placentas can be used to reliably test the ability of any given nano-particle to penetrate the placental barrier. The model does not, however, yield any information on the mechanism used by the particle to penetrate this complex organ.

Researchers are therefore tending to fall back on the use of simple cell cultures and other modelling systems. An individual cell, possibly taken from the epithelium and subsequently cultivated and propagated in a petri dish, is perfectly suited to a whole range of different experiments. However, researchers cannot be certain that the cells in the petri dish will ultimately behave like those in the human body. The new model that the Empa team under Tina Buerki described in the scientific journal Nanoscale at the end of last year is, by contrast, three-dimensional and consists of more than one cell type. The cells exist in a tissue-like environment analogous to the placenta and can be experimented on for a longer period of time.

Golden test candidate

In order to create the model, the research team used the "hanging drop" technology developed by Insphero AG. This technology allows models to be created without "scaffolding," which can hinder free access of the nano-particles to the cells in the subsequent transport tests. Rather than introducing the cells in a flat petri dish, a special device, in which the cells in the hanging drops combine to form spherical micro-tissue, is used. The resulting micro-tissue mimics the human placenta much more closely than cells cultivated on a "rigid" culture dish. Experiments can be carried out much more quickly using the 3-D model than with the real placenta and, significantly, on the most widely differing types of nano-particle. In this way, those nano-particles that show potentially toxic effects or demonstrate desirable transport behaviour can be efficiently pre-selected and the results verified using a real placenta.

The model has already proved itself in a second study, which the team has just published in the scientific journal Nanomedicine. Buerki's team has come up with an absorption mechanism for gold particles that could be used in a range of medicinal applications. The Empa team looked at gold particles of various sizes and different surface modifications. In accordance with the results of other studies, the researchers discovered that small gold particles were able to penetrate the placental barrier more easily. In addition, fewer particles passed through the barrier if they were carrying polyethylene glycol (PEG) on their surfaces. These are chain-forming molecules that almost completely envelope the particles. PEG is often used in medicine to allow particles and other small structures to travel "incognito" in the body, thus preventing them being identified and removed by the immune system. "It therefore appears possible to control the movement of nano-particles through the placenta by means of their properties," Buerki explains.

Medicines for pregnant women that do not harm the child

Empa's research team is keen to further develop this 3-D model in the future. The team is hoping to augment the model using a dynamic component. This would, for example, mean introducing the micro-tissue in a micro-fluid system able to simulate blood circulation in the mother and child. Another approach would be to combine the model of the placenta with other models. "With the model of a foetus, for example," Buerki suggests. In this way, complex organ interactions could also be incorporated and it would be possible, for example, to discover whether the placenta releases foetus-damaging substances as a reaction to certain nano-particles.

"With these studies, we are hoping to lay the foundations for the safe but nevertheless effective use of nano-medicines during pregnancy," Buerki continued. If we understand the transport mechanisms of nano-materials through the placental barrier well enough, we believe we can develop new carrier systems for therapeutic agents that can be safely given to pregnant women. This is because many women are forced to take medicines even during pregnancy patients suffering from epilepsy or diabetes, for example, or patients that have contracted life-threatening infections. Nano-carriers must be chosen which are unable to penetrate the placental barrier. It is also possible, for example, to provide such carriers with "address labels," which ensure that the medicine shuttle is transported to the correct organ i.e. to the diseased organ and is unable to penetrate the placenta. This would allow the medicine to be released first and foremost into the mother. Consequently, the amounts absorbed by the foetus or embryoand therefore the risk to the unborn child are significantly reduced.

Explore further: New placenta model could reveal how birth defect-causing infections cross from mom to baby

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

More here:

Medication for the unborn baby - Medical Xpress

‘Nanomedicine’: Potentially revolutionary class of drugs are made-in … – CTV News

Posted on August 4, 2017 by Dook Domini

It's rare for researchers to discover a new class of drugs, but a University of Calgary microbiology professor recently did so -- by accident and now hopes to revolutionize autoimmune disease treatment.

In 2004, Dr. Pere Santamaria and his research lab team at the Cumming School of Medicine conducted an experiment to image a mouse pancreas, using nanoparticles coated in pancreatic proteins.

The work didnt go as planned.

Our experiment was a complete failure, he recently told CTV Calgary. We were actually quite depressed, frustrated about the outcome of that.

But the team was surprised to discover the nanoparticles had a major effect on the mice: resetting their immune systems.

The team realized that, by using nanoparticles, they can deliver disease-specific proteins to white blood cells, which will then go on to reprogram the cells to actively suppress the disease.

Whats more, the nanoparticles stop the disease without compromising the immune system, as current treatments often do.

Santamarias team believes nanomedicine drugs can be modified to treat all kinds of autoimmune and inflammatory diseases, including Type 1 diabetes, multiple sclerosis and rheumatoid arthritis.

Convinced that nanomedicine has the potential to disrupt the pharmaceutical industry, Santamaria founded a company to explore the possibilities, called Parvus Therapeutics Inc.

This past spring, Novartis, one of the worlds largest pharmaceutical companies, entered into a license and collaboration agreement with Parvus to fund the process of developing nanomedicine.

Under the terms of the agreement, Parvus will receive research funding to support its clinical activities, while Novartis receives worldwide rights to use Parvus technology to develop and commercialize products for the treatment of type 1 diabetes.

Its a good partnership, Santamaria said in a University of Calgary announcement. Bringing a drug to market requires science as well as money.

Santamaria cant say how long it might be before nanomedicine can be used to create human therapies, but he says everyone involved is working aggressively to make it happen.

With a report from CTV Calgarys Kevin Fleming

See the article here:

'Nanomedicine': Potentially revolutionary class of drugs are made-in ... - CTV News

‘Blazing the trail’: University of Calgary research could lead to cures … – CBC.ca

Posted on August 3, 2017 by Dook Domini

Researchers at the University of Calgary say their work in the field of "nanomedicine"could lead to cures for Type 1 diabetes, multiple sclerosis and many more diseases.

Dr. Pere Santamaria said the process involves "nanoparticles" thousands of times smaller than a typicalhuman cell that could be used to stop the body from attacking itself.

That, he said, could potentially lead to cures for autoimmunedisorders.

"There are no drugs that can do that today,"said Santamaria, aprofessor ofimmunology at the University of Calgary.

"Other drugs that are being used to treat chronic inflammatory disorders impair the ability of the immune system to do its job, so there are secondary effects and longterm complications our drugs don't do that."

Pharmaceutical company Novartis has partnered with Santamaria's own company, Parvus Therapeutics, to work on developing the nanomedicines and take the drugs to market.

Now with support and funding, Santamariasaid the new drug"has the potential to revolutionizemedicine" if the drugs pass clinical testing.

Santamariasaid autoimmune disordersarecaused by white blood cells attacking the tissues in a person'sown body.

Pharmaceutical company Novartis has partnered with Dr. Santamaria's Parvus Therapeutics to work on developing nanomedicines to cure autoimmune disorders and take the drugs to market. (CBC)

Type 1 diabetesis treatable with insulin, but there is no cure. It's the same for many other diseases.

"Our drugs aim to resolve the inflammation of the tissue, the attack of the tissue, and resolve that process altogether," Santamaria said.

He said the nanoparticles could halt disorders without impairing the rest of the immune system.

"So we can reset the immune system to its steady state that means the healthy state without impairing the ability of our immune system to protect us against infections and cancer,"Santamariasaid.

Santamaria said the nanoparticleswere discovered during an experiment years ago, and the initialtestresults"made nosensewhatsoever." Since that day, the nanomedicines havebeen in development and he credits the progress to curiosity.

"We almost shoved them under the rug," Santamaria said."We didn't do that. Fortunately, we were pursued wth curiosity of researching."

Santamaria said the process of taking a discovery from the research laboratory to the marketplace is enormously complex and the drug has yet to go through preclinical trials.

Because nanomedicine is such a new field of research, there is no firm timeline on when the medicinescould be available if they pass human trials.

"Our nanomedicineis a new class of drug ... so we're basically blazing the trail," Santamaria said.

"We hope that we can carry that torch and be an example for all the investigators that might follow suit, that may run into discoveries such as the ones that we've made and hopefully they can follow in our footsteps."

Link:

'Blazing the trail': University of Calgary research could lead to cures ... - CBC.ca

Futurist Transhuman News Blog

Category Archives: Nano Medicine

jo lab – Cardiovascular Mechanobiology and Nanomedicine

Nanomedicine Conferences | Nanotechnology Events …

Nanomedicine – Official Site

Nanomedicine Fact Sheet – National Human Genome Research …

Nano Medicine

Top Nanomedicine Conferences|DrugDelivery meetings …

Nanomedicine – Overview

Regenerative Nanomedicine Lab – yimlab.com

Web Hosting Services – Northeastern ITS

Regenerative Nanomedicine Lab

Euroscicon – Nanotech & Nanobiotechnology

Growth in the Global Nanomedicine Market 2017-2021 trends … – satPRnews (press release)

New report shares details about Europe’s nanomedicine market – WhaTech

Are nano drug delivery and telehealth solutions a deadly combo for disease? – EPM Magazine

Nanomedicinal products: a survey on specific toxicity and side effects – Dove Medical Press

Growth in Nanomedicine market-2017 trends, forecasts, analysis – satPRnews (press release)

Targeting tumours: IBBME researchers investigate biological barriers to nanomedicine delivery – U of T Engineering News

Medication for the unborn baby – Medical Xpress

‘Nanomedicine’: Potentially revolutionary class of drugs are made-in … – CTV News

‘Blazing the trail’: University of Calgary research could lead to cures … – CBC.ca