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Mesothelioma Law Firm | Sokolove Law

Trusted Nationwide for Mesothelioma Legal Services

The national reach of Sokolove Law allows us to help victims in any state, and to maximize the value of their cases and potential settlements.

Our goal is to maximize the compensation that a mesothelioma victim may be entitled to. What makes Sokolove Law unique is that we are not restricted to filing lawsuits in certain states. As a national law firm, we will file wherever a mesothelioma or asbestos-related claim can be best litigated, in order to increase the value of a case.

For more information, we recommend reading: 5 Tips for Finding the Right Mesothelioma Lawyer for You

A mesothelioma law firm, or a law firm that specializes inasbestos cases, files claims on behalf of those suffering from diseases triggered by asbestos, which includes mesothelioma. These firms develop a deep understanding of the nitty-gritty details involved in bringing justice to the victims and families impacted by these devastating diseases.

Torts, as theyre known, or, more commonly, civil actions, are part of an extremely complex area of the law. This is the area where asbestos litigation falls. All U.S. states have their own unique statutes, and these statues can vary on things like burden-of-proof, meaning one states requirements could be different or even more demanding than anothers.

Thats why its best to work with an experienced lawyer. Firms like Sokolove Law have for years prioritized keeping up with the latest mesothelioma research and asbestos-related legal developments. Sokolove Law maintains massive databases containing information related to virtually every aspect of the asbestos industry.

Whenever youre considering legal action, its vital that you interview a potential law firm and check their past experience in mesothelioma claims, settlements and specialized legal experience.

Here are some questions you might ask if you were looking to partner with a mesothelioma law firm:

How many years of experience does yourmesothelioma law firm have?

Will youtake mycase on a contingency basis?

What are the typical outcomes of yourmesothelioma cases? Out-of-court settlement? Win? Loss? Appeal?

Will Ibe able to speak with members of yourlaw firm as needed? Will mycalls be returned promptly and your questions answered clearly?

How many mesothelioma (not just asbestos) cases or claims has yourlaw firm handled?

Will mycase be handled on an individual basis, or bundled with several other similar cases? (This may hurt you if your case is a strong one, but could be helpful with weaker cases.)

Does your mesotheliomalaw firm have a nationwide network of attorneys and lawyers who will share their research and expertise in order to build a solid case on mybehalf?

Will yourlaw firm be handling mycase personally? (At times law firms may refer your case to another firm that may be better suited to help in your situation often providing you with the services of both their firm and another at no extra cost to you.)

Remember, its in your best interest to be comfortable with the mesothelioma law firm and attorneys that handle your case.

Sokolove Laws staff of experienced mesothelioma paralegals is here to help you and to answer any questions you might have about filing a mesothelioma lawsuit. Dont wait request a free legal consultation today.

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Mesothelioma Law Firm | Sokolove Law

Mesothelioma | Memorial Sloan Kettering Cancer Center

Mesothelioma is a cancer that affects tissue called the mesothelium, a lining that covers and protects many internal organs. Pleural and peritoneal mesothelioma account for most of the 2,000 to 3,000 new cases of the disease diagnosed in the United States each year. Less common types of mesothelioma include pericardial mesothelioma, which affects the lining surrounding the heart, and testicular mesothelioma.

There are two main types of mesothelioma. The type you have depends on which kind of tissue the cancer begins in.

Pleural mesothelioma affects the pleura, a membrane that protects your lungs.

Peritoneal mesothelioma affects your peritoneal membrane, the tissue that surrounds your abdominal organs.

The most common cause of mesothelioma is exposure to asbestos. This building material was once regularly used for insulation and fire prevention. Asbestos exposure can also also lead to a similar but noncancerous disease, asbestosis.

There are other risk factorsfor mesothelioma as well.

Pleural mesothelioma is the most common type of mesothelioma, accounting for about 75 percent of all cases diagnosed in the United States. It affects the pleura, a membrane that protects your lungs. Sometimes pleural mesothelioma spreads (metastasizes) and affects your outer chest wall, lymph nodes, and other parts of the body.

Memorial Sloan Kettering created the multipronged approach to treating this disease, combining surgery to remove cancerous tissue with chemotherapy and/or radiation treatment. Our radiation oncologists have developed cutting-edge techniques, such as intensity-modulated radiation therapy (IMRT). IMRT allows us to target tumors along the entire pleura (membrane) very precisely while minimizing damage to nearby organs.

Quick and accurate diagnosis is very important with pleural mesothelioma so that valuable months and even years arent lost for giving you the best treatments and opportunities for possibly taking part in clinical trials.

Learn more about how we customize a treatment plan for you.

Peritoneal mesothelioma affects the tissue (membrane) that covers and helps lubricate your abdominal organs. This tissue also helps keep your abdominal organs in place. Peritoneal mesothelioma accounts for 10 to 20 percent of new mesothelioma cases diagnosed in the United States each year.

In most cases, experts are still not sure why people develop peritoneal mesothelioma. Asbestos and radiation exposure are risk factors. So is having chronic peritoneal inflammation. However, most people have no risk factors.

Because peritoneal mesothelioma is rare, it sometimes goes undiagnosed for long stretches of time. If your doctor suspects that you have the disease, its best to meet with one of our mesothelioma specialists, who are experienced in diagnosing and treating this condition.

He or she will examine you and work with an MSK pathologist with expertise in identifying mesothelioma cells and determining which subtype you may have.

The major subtypes of peritoneal mesothelioma are:

Once your treatment team has identified your subtype, we can prescribe a treatment plan customized for you. For example, within the epithelial subtype alone, there are varying grades of disease. And if you have the subtype known as well-differentiated papillary mesothelioma, you may need limited treatment, such as monitoring with a radiology test.

Learn more about how we customize a treatment plan for you.

Most doctors and oncologists see very few people withthis relatively rare cancer. The symptoms are often misdiagnosed as lung cancer or another illness. This can result in the loss of valuable treatment time that can affect your outcome.

As a hospital with one of the nations largest volumes of patients with mesothelioma, we offer a unique level of expertise in diagnosing and treating people with this disease, whatever stage or type it may be. We can find solutions for you.

Because all of our mesothelioma experts work together so closely we meet every other week to strategize on options for new as well as established patients were able to give you the treatment strategy most likely to work for you. Well often turn to our very large patient database on pleural and peritoneal mesothelioma for help in guiding us on who might benefit most from various types of surgery, for example. It can also help us in deciding which clinical trial to recommend.

Our patients also benefit from the fact that we do so much research at MSK and know the latest about vaccines, immunotherapy drugs, cutting-edge radiation techniques, and other novel ways of identifying and treating mesothelioma.

We work hard to improve the quality and length of life of people with mesothelioma. We offer the newest in pain management and relief from other symptoms, along with a follow-up care and survivorship program that can help keep you active and feeling cared for as long as possible.

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Mesothelioma | Memorial Sloan Kettering Cancer Center

Mesothelioma Veterans Center – Access Benefits & VA Claims

Choose Your Service Branch Below What is Mesothelioma?

Mesothelioma is a cancer of the lining of the lungs (pleural mesothelioma) or abdomen (peritoneal mesothelioma) that is caused by exposure to asbestos. In over 30% of all mesothelioma cases, asbestos exposure happened during military service. Veterans from all branches of service are at risk, with the most common being the United States Navy and the Marines. There are a variety of mesothelioma treatments available, as well as doctors in the VA system who are capable of treating it.

Veterans Benefits are available for people in the form of VA Disability, Aid & Attendance and more. Learn more about Asbestos in the military and the benefits available for you.

Learn more about this disease that affects the lining of the lungs (pleural) or abdomen (peritoneal). Find the top treatment options and ways to improve your prognosis.

Veterans with mesothelioma are often eligible for thousands of dollars in disability compensation, access to top mesothelioma specialists and more.

Hundreds of thousands of veterans were exposed to asbestos during their service in the military. Learn how and where you may have been exposed.

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Mesothelioma Veterans Center – Access Benefits & VA Claims

Malignant Mesothelioma (Asbestos Cancer) > The Mesothelioma …

Malignant mesothelioma (pronounced “mez-o-theel-e-oh-ma”), also known as “asbestos cancer,” is a rare form of cancer found in the lining of the heart, lungs, abdomen, or the internal reproductive organs. This lining is called the mesothelium and is where mesothelioma gets its name.

Because tumors of the mesothelium are rarely benign (non cancerous), cancerous malignant mesothelioma is usually referred to simply as “mesothelioma,” or in casual terms simply “meso.”

The mesothelium covers various organs in the body protecting them and allowing organs to move against each other as the lungs expand and contract or the heart beats. Where the mesothelium covers the internal organs, it is called the visceral mesothelium and where it covers the body walls, it is called the parietal mesothelium.

Malignant mesothelioma occurs when cells within the mesothelium become abnormal and divide uncontrollably. If not caught early enough, the cancer may metastasize, spreading to other organs of the body. While it is a very aggressive form of cancer, several treatment options are available for malignant mesothelioma.

The only known cause of mesothelioma is asbestos. Because asbestos exposure is the only known cause of mesothelioma, it is sometimes referred to as “asbestos cancer.” However, malignant mesothelioma is not the only cancer caused by asbestos. Exposure to asbestos can also cause laryngeal, colon, and lung cancer.

There is no known safe level of asbestos exposure, but asbestos cancers are dose dependent, meaning those exposed for longer periods of time and to greater amounts of asbestos are more likely to develop asbestos-related disease. If you were exposed to asbestos, you should tell your physician so he or she can make a determination for appropriate testing based on your history of exposure and symptoms.

One of the earliest descriptions of malignant mesothelioma was written in 18701, although the tumor was referred to as tuberkelhnliche lymphadenome (“tubercle-like” lymphadenoma) in this early, German-language review. It wasn’t until the start of the 19th century that tumors arising out of the mesothelium were named mesotheliomas. The process of appropriately identifying, and thus naming, mesothelioma was not without some debate, confusion, and even controversy.

In an article that would help define the modern ideas on the pathology and diagnosis of mesothelioma, Klemperer and Rabin’s 1930 “Primary Neoplasms of the Pleura: A Report of Five Cases” noted that thirty different names had been used to describe the neoplasms being studied:

The names applied most frequently, endothelioma, endothelial carcinoma, carcinoma, sarcoma, lymphangitis proliferans, sarcocarcinoma and mesothelioma, are indicative of the different morphologic pictures and the different opinions of the authors as to the point of origin. To make this confusion more complete, there have been included in the literature on primary tumors of the pleura a number of cases that, on critical examination, are proved to originate definitely in the lungs or in the bronchi.”2

Even as late as 1943the year many consider asbestos was determined a cause mesothelioma (see Wedler, below)researchers suggested “pleuroma” as a name for these tumors3, however, mesothelioma gradually became the accepted term. Likely as a result of relative rarity of mesothelioma, the connections between asbestos and mesothelioma began to be made even as mesothelioma itself was still not well understood or identified.

In 1933, London pathologist Steven Roodhouse Gloyne published a study in which he discussed the movement of asbestos fibers through the lymph system and the particularly high concentrations of asbestos that collected in the lymph nodes in the central chest in a person with asbestosis4. Two years later, in 1935, Gloyne is considered the first to make a possible connection between occupational asbestos exposures and mesothelioma.

Gloyne described malignancies arising from the pleura of an asbestosis victim5, noting that “at the moment” there was no indication that the tumor correlated to the asbestosis present. However, in 1938, when the German government began to recognize and compensate lung cancer as an occupational disease of asbestos workers, mesothelioma was included as a compensable respiratory cancer.

What is often regarded as the first study to connect mesothelioma with asbestos was published in 1943 by German researcher, Dr. H.W. Wedler6. Wedler reviewed a collection of autopsy records belonging to asbestosis victims, his results revealing an excess of both lung and pleural malignancies. Also of interest in Wedler’s study, was his observation of an often a long interval between exposure and the development of cancer and his assertion that these diseases must be regarded as occupational.

Several more publications in a similar vein followed, and throughout the 1940s and 1950s, articles discussing asbestosis cases often mentioned accompanying lung cancers and/or mesotheliomas. In 1954, F. Leicher reported the first case of peritoneal mesothelioma in an asbestos textile factory spinner7. Many researchers, physicians, and other specialists believe the causal relationship between asbestos and mesothelioma was, or at least could, have been established by the mid-1950s. (Interestingly, even as late as 1955, some studies did not refer directly to “mesothelioma,” but to a malignancy of the pleura or similar.)

It was an article published by South African researchers J.C. Wagner, Christopher Sleggs, and Paul Marchand that is generally attributed as the removing any doubts that asbestos causes mesothelioma. Wagner had initially been hired by the South African Government Mining Engineer to study occupational diseases, namely, asbestosis; however, Wagner began to focus his attention on the unusual pleural tumors he was finding during his research. It was not a decision the mining industry in South Africa was happy about, as they were busy investing in new operations to meet the growing global demands for asbestos.

The study, first presented at a conference in Johannesburg in 1959 and published in 1960 in the British Journal of Medicine, detailed 33 cases of mesothelioma with all but one case having a proven asbestos exposure history. In eight cases, their exposure history was occupational, however, some twenty of the mesothelioma cases discussed simply lived as infants near the mines.

Although the language of Wagner’s study left the association between asbestos and mesothelioma “possible,” the results of such damaging evidence against asbestos in occupational and, perhaps more importantly, bystander asbestos exposures was not lost on the industry. Partly as a result of pressures from industrial interests, Wagner left South Africa in 1962 for a new position in the UK. Any lingering doubts about asbestos’ tie to mesothelioma left open by Wagner were shortly quieted by several studies which further confirmed the link.

In the 50s and 60s, New Jersey physician Irving J. Selikoff saw several men suffering from pulmonary abnormalities as a result of inhaling asbestos dust on the job at the Patterson, NJ UNARCO (Union Asbestos & Rubber Company) plant. UNARCO’s specialty was in producing asbestos insulation materials for the US Navy. When several of Selikoff’s UNARCO patients died as a result of cancer, he contacted UNARCO requesting their participation in a study of workers’ health.

When UNARCO declined, Selikoff tried a different tactic. If the makers of the insulation were being injured by asbestos, Selikoff supposed, those installing it might face similar risks. Early in 1962, Selikoff contacted the International Association of Heat & Frost Insulators & Asbestos Workers (New York Local 12 and Newark Local 32). The union officials were, in fact, quite concerned about workers’ health. So much so, that they had contacted the Industrial Hygiene Foundation (IHF) about them several years prior. Originally called the Air Hygiene Foundation, the IHF was almost wholey industry-funded, so their responses to the union’s concerns were, not surprisingly, reassurances about the safe handling of asbestos insulation materials.

Over the course of the next year, Selikoff examined more than a thousand insulators, performing pulmonary function tests and administering x-rays. Selikoff finally presented his findings in 1964 at the New York Academy of Science sponsored conference ‘Biological Effects of Asbestos.’ His results were staggering. Among the insulators, mortality was 25% higher than was expected, and not from asbestosis alone, but from lung cancer, stomach cancer, colon cancer, rectal cancer, colorectal cancer, and malignant mesothelioma.

Along with Selikoff’s presentation at the 1964 conference, Wagner and other researchers presented further evidence of the connection between asbestos and mesothelioma. British physician Molly Newhouse echoed Wagner’s own findings when she presented her research regarding mesothelioma cases among people who lived near, but were not employed by, a London asbestos factory. Many of the presentations emphasized that victims often did not suffer long or heavy exposures, work with asbestos, nor have asbestosis.

In 1968, the British Medical Journal asserted that “at the end of 1965, it was clear that asbestos workers [were] at special risk of developing cancers of at least two typebronchial carcinoma and mesothelioma.”

Last update: December 03, 2015. 02:54:51 pm.

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Malignant Mesothelioma (Asbestos Cancer) > The Mesothelioma …

Time Between Surgeries Helps Predict Mesothelioma Survival – Asbestos.com

A new study from researchers at the City of Hope cancer center in Los Angeles and Wake Forest University School of Medicine in Winston-Salem, North Carolina, reveals how the length of time between initial and follow-up cytoreduction surgery and HIPEC plays a role in patient survival.

The study, published in June in the Journal of Surgical Oncology, shows peritoneal mesothelioma patients who repeat the procedure between one and two years after the initial surgery have the most favorable outcome, with a median overall survival of nearly four years.

Peritoneal mesothelioma is an aggressive, asbestos-related cancer, and recurrence is common.

These results are very promising for a select group of patients who recur after cytoredutive surgery (CRS) and HIPEC, Dr. Konstantinos Votanopoulos, associate professor of surgery at Wake Forest School of Medicine, told Asbestos.com. In this group, a complete CRS and HIPEC essentially resets the clock in terms of anticipated survival.

The multimodal approach of CRS followed by heated intraperitoneal chemotherapy (HIPEC) is the standard treatment option for peritoneal mesothelioma patients.

In 2013, researchers at Moffitt Cancer Center concluded patients who opted for a second procedure survived nearly three times as long as those who underwent only one procedure.

The goal of CRS, also known as debulking, is to remove any visible tumors or cancer from multiple sites in the abdomen. It may require removing some or all parts of major organs, including the gallbladder, liver, pancreas, stomach, spleen and intestinal tract.

HIPEC involves delivering heated chemotherapy drugs directly to the abdominal cavity to treat any cancer cells that may remain. It is considered a risky procedure, and not all peritoneal mesothelioma patients are candidates.

Sometimes, multiple rounds of HIPEC are necessary to send the cancer into remission.

In addition to peritoneal mesothelioma, CRS and HIPEC are used to treat other gastrointestinal cancers and peritoneal surface malignancies including cancers of the colon, appendix and gallbladder.

Using a City of Hope database of 1,314 CRS and HIPEC procedures performed between February 1993 and December 2015, Konstantinidis and his team identified 103 (8.5 percent) patients who underwent repeat procedures.

The group included:

Mesothelioma patients carried the most significant disparity of overall survival, according to the time interval between first and second CRS and HIPEC procedures.

Overall survival rates for peritoneal mesothelioma patients in the study were:

Median overall survival for all peritoneal mesothelioma patients in the study was 2.4 years.

All other cancer patients who underwent repeat procedures after two years saw a significant increase in overall survival compared to those in the one- to two-year range, including a four-year difference for low-grade appendiceal cancer and three-year difference for colon cancer patients.

The median overall survival for all cancers in that interval was seven years, far longer than mesothelioma patients in that group, for all patients who underwent repeat procedures after at least two years. This can be attributed to the high recurrence rate of peritoneal mesothelioma and its ability to spread quickly.

Although the study links repeated procedures more than two years after initial surgery with the best overall survival, the optimal time interval for mesothelioma patients is between the first and second year.

Essentially, the amount of time between procedures functions as a powerful selection tool to predict the patients that will do well, Votanopoulos said. A recurrence within a year from the initial operation is a sign that the tumor is very aggressive and more surgery is unlikely to offer a survival benefit.

Researchers at Wake Forest were part of a 2015 study analyzing the survival-time gap between the two most common types of mesothelioma peritoneal and pleural.

The study showed the median survival for peritoneal patients is four times that of a patient diagnosed with pleural mesothelioma, which develops on the protective lining surrounding the lungs and accounts for roughly 70 percent of all mesothelioma cases.

Median survival for peritoneal patients was more than six years, compared to just 18 months for pleural patients.

Advancements in therapy, most notably the cytoreductive surgery and HIPEC procedures, are credited for the significant difference in prognosis between the two types.

Combining heated chemotherapy with aggressive surgery has not been as successful for treating pleural mesothelioma.

There are still limitations for CRS and HIPEC. Peritoneal patients are eligible on a case-by-case basis, depending on tumor growth and whether the cancer has spread outside of the abdominal cavity.

But ongoing research continues to demonstrate the procedures as the standard therapy for peritoneal mesothelioma.

A complete CRS and HIPEC, or in other words resection of all visible tumor, is the most important factor in predicting improved survival, Votanopoulos said. Therefore, early detection of recurrence when the volume of disease is low is of paramount importance.

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Time Between Surgeries Helps Predict Mesothelioma Survival – Asbestos.com

Testicular and Cardiac Mesothelioma – Surviving Mesothelioma

Most cases of mesothelioma occur around the lungs (pleural) or around the abdomen (peritoneal). However, there are two rare subtypes that can occur. One is found around the testis and the other can be found around the heart. Estimates place each type to less than 50 cases a year.

Testicular Mesothelioma is also called paratesticular or mesothelioma of the tunica vaginalis testis. It is a rare subtype of mesothelioma that involves the testis.

A major risk factor is exposure to asbestos, typically with a long latency between exposure and diagnosis.

The most common symptom is a mass or hydrocele (buildup of fluid) inside the scrotum. Symptoms of testicular mesothelioma may include scrotal problems, pain, and discomfort. Your doctor may use a physical examination, X-ray or other imaging to detect the lesions. An ultrasound may also be used. A biopsy may be performed and the tumor may be examined by a pathologist to determine exactly what type of cancer it is. Pathologists use immunohistochemical staining to help them identify the genetic markers of various cancers.

Treatment of testicular mesothelioma may include surgery followed by radiation therapy and chemotherapy. Recent studies have concluded that surgery may be curative in some cases. For example, in one study, two patients with this disease were treated by radical inguinal orchiectomy where one or both testicles and the spermatic cord are surgically removed. According to their doctors, Both patients are currently in complete remission. These doctors go on to say that the use of chemotherapy and radiation therapy may not always be necessary in this type of mesothelioma. However, other studies have concluded that treatment is only curative in early stages.

The mortality rate from testicular mesothelioma has been reported to be 53% over a mean follow-up time of two years. Even with treatment, this tumor has a very poor prognosis with a median survival of about 23 months.

Pericardial Mesothelioma an extremely rare subtype of the asbestos-caused cancers. The cancer develops within the pericardium, the membrane that surrounds the heart. This membrane actually has two layers: An outer layer called parietal and an inner layer known as visceral.

Primary pericardial malignant mesothelioma is extremely rare with an incidence less than 0.0022%. It comprises 0.7% of all mesothelioma cases. As of 2012, approximately 350 cases of pericardial mesothelioma have been reported in the peer reviewed medical literature.

Due to its rarity and lack of studies, the role of asbestos in pericardial mesothelioma is unclear.

The symptoms of pericardial malignant are usually not specific and may resemble those of other heart conditions. The symptoms may also relate to a fluid buildup around the heart and thickening of the pericardial layers. The symptoms may also be related to constrictive pericarditis, heart attack, or congestive heart failure. Symptoms that have been reported include: heart palpitations or irregular heartbeat (arrhythmia), difficulty breathing, shortness of breath, fatigue and chest pains. If you are experiencing any of these symptoms see your licensed healthcare provider immediately.

Treatment options are limited because the tumors are so close to the heart.

With the exception of a handful of case reports, patients typically pass away within 6-10 months of diagnosis. An example of a longer term survivor is a 59-year-old woman who underwent surgery for malignant pericardial mesothelioma. The tumor was successfully removed with clean surgical margins. The cell type of her mesothelioma was epithelioid. The patient tolerated the operation and chemotherapy without any complications. She remained alive for almost 3 years after surgery.

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Testicular and Cardiac Mesothelioma – Surviving Mesothelioma

Targeted Therapy May Soon be Primary Approach for Mesothelioma Treatment – MesotheliomaHelp.org (blog)

Targeted care optimizes the potential for success of mesothelioma treatment and provides the patient with the assurance that his cancer is being treated according to his unique characteristics. Personalized cancer treatment is gaining popularity among physicians and oncologists, however, it is far from mainstream. If researchers from University of Michigan have their way, however, treatment for all cancers will soon be personalized based on the patients biomarkers.

In a new study released from researchers at the University of Michigan Comprehensive Cancer Center, the team looked at the DNA sequencing of nearly 500 patients. Of those, almost 75 percent of them had biomarkers that can be targeted by either existing or experimental anti-cancer treatments.

Biomarkers, including EGFR and PD-L1, that are present in mesothelioma and other cancers, help indicate the reason for the growth of the cancers and are the focus of current and experimental treatments used to fight the deadly disease. Many clinical trials are being offered now for mesothelioma patients that pinpoint particular biomarkers. One well-known trial is the Keynote-28 trial, that eight-year mesothelioma survivor Mavis Nye of England participated in, that targeted the PD-L1 marker and put her mesothelioma in remission.

Availability of biomarker trials is crucial for being able to act on these results, says Erin Cobain, M.D., clinical lecturer of hematology/oncology at the University of Michigan Medical School.

The value of the study lies in the method used to sequence the genes and the process for developing patient care based on the results of the sequencing. Using next generation sequencing the team reports that the genetic sequencing looks at all of the DNA and RNA expressed within a tumor, as well as sequencing the patients normal genome to identify genes that may be inherited from the patients parents.

Erin Cobain, M.D., University of Michigan

Using MI-ONCOSEQ, the tool developed at the Michigan Oncology Sequencing Center, the test uses a fresh biopsy from the patient, as opposed to frozen tissue samples used by commercially-available tools, allowing the Michigan researchers to perform a more comprehensive analysis. According to the press release, commercial tests analyze only about 350 genes compared to MI-ONCOSEQs ability to cover at least 1,700 genes.

Mesothelioma is an incurable, asbestos-caused cancer of the membranes that surround many of the bodys vital organs, including the lungs. The cancer is highly aggressive and is resistant to many cancer treatments making it a difficult disease to treat effectively. Thus, developing a treatment protocol that specifically targets the genetic makeup of the patients cancer is vital for improving survival rates.

More here:

Targeted Therapy May Soon be Primary Approach for Mesothelioma Treatment – MesotheliomaHelp.org (blog)

The Mesothelioma Victims Center Now Urges a Diagnosed Navy … – PR Newswire (press release)

NEW YORK, June 22, 2017 /PRNewswire/ –The Mesothelioma Victims Center says, “We are certain most people have seen a cable TV commercial sponsored by a law firm offering a free book about mesothelioma. Typically, this is a law firm’s marketing effort to identify people who have mesothelioma, and in our opinion the book is the bait.

“If you are a US Navy Veteran or person with mesothelioma, we offer a higher quality resource than a generic book about an extremely rare form of cancer caused by asbestos exposure as we would like to discuss anytime at 800-714-0303. As an example, we offer instant access to the nation’s leading mesothelioma attorneys who can completely explain the mesothelioma financial compensation process.

“Once we have some basic information about the person, we will do our own on-the-spot research to make certain the diagnosed Navy Veteran or person has access to their region’s top oncologists, who have experience treating mesothelioma. A Navy Veteran or person with mesothelioma will not get these types of resources in a free book about mesothelioma. The physicians we suggest are not associated with a VA hospital because these hospitals, in our opinion, provide an inferior service for Veterans with an aggressive cancer such as mesothelioma as we would like to explain anytime at 800-714-0303.” http://MesotheliomaVictimsCenter.Com

Customized services offered by the Mesothelioma Victims Center to any US Navy Veteran that are vastly superior to a generic book about mesothelioma:

“Mesothelioma should not tear a family apart as we would like to discuss anytime at 800-714-0303. Mesothelioma can hopefully bring a family together,” says the Mesothelioma Victims Center. http://MesotheliomaVictimsCenter.Com

According to the CDC the states indicated with the highest incidence of mesotheliomainclude Maine, Massachusetts, Connecticut, Maryland,New Jersey, Pennsylvania, Ohio, West Virginia, Virginia,Michigan, Illinois, Minnesota, Louisiana, Washington, and Oregon.

However, based on the calls the Mesothelioma Victims Center receives a US Navy Veteran with mesothelioma could live in any state including New York, Florida, California, Texas,Illinois, Ohio, Iowa,Indiana, Missouri, North Carolina,Kentucky, Tennessee, Georgia,Alabama, Oklahoma, Arkansas, Kansas, Nebraska, North Dakota, Colorado, New Mexico, Utah, Nevada,Arizona, Idaho, or Alaska.

High-risk work groups for exposure to asbestos include US Navy Veterans, power plant workers,shipyard workers, oil refinery workers, steel mill workers,manufacturing/factoryworkers, pulp or paper mill workers, plumbers, electricians, auto mechanics, machinists, miners, construction workers, insulators, rail road worker, roofers, or firemen. As a rule, these types of workers were exposed to asbestos in the 1950’s, 1960’s, 1970’s, or 1980’s. US Navy Veterans make up about one-third of all US Citizens who are diagnosed with mesothelioma each year. http://MesotheliomaVictimsCenter.Com

The Mesothelioma Victims Center says, “When it comes to obtaining the best mesothelioma settlement, the quality of the attorney matters, as we would like to explain anytime at 800-714-0303. Please don’t shortchange yourself when it comes to mesothelioma financial compensation.” http://MesotheliomaVictimsCenter.Com

For more information about mesothelioma please refer to the National Institutes of Health’s web site related to this rare form of cancer: http://www.nlm.nih.gov/medlineplus/mesothelioma.html

Media Contact:Michael Thomas163186@email4pr.com 800-714-0303

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/the-mesothelioma-victims-center-now-urges-a-diagnosed-navy-veteran-to-call-them-about-nations-top-lawyers-for-honest-answers-about-compensation-rather-than-a-generic-book-300478125.html

SOURCE Mesothelioma Victims Center

http://MesotheliomaVictimsCenter.Com

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The Mesothelioma Victims Center Now Urges a Diagnosed Navy … – PR Newswire (press release)

Polish Study Confirms That Mesothelioma Risk Only Increases With … – Mesothelioma.net Blog (blog)

Malignant mesothelioma is a cancer that is unlike all others in many ways. One of the most notable and frustrating of these is that mesotheliomasrisks continue to rise as more time passes from exposure to asbestos. This is in direct contrast to other types of cancers: for example, when a smoker quits smoking, every day that goes by without a cigarette their risk of being diagnosed with lung cancer decreases. The same is true for those who give up other harmful exposures or who change sedentary lifestyles to more active ones.

This has long been suspected in the mesothelioma research community, and was recently confirmed by a study conducted by Polish scientists at the Nofer Institute of Occupational Medicine. Their study was comprehensive, comparing information from 131 patients diagnosed with pleural mesothelioma to a control group of 655 patients enrolled over a 14-year period in a health surveillance program specifically targeting asbestos-related diseases like mesothelioma, asbestosis and asbestos-related lung cancer.

The researchers found that the moretime went by followingasbestos exposure, the higher the risk of a later diagnosis of the disease. The scientists report said in part, The results show that the risk of pleural mesothelioma continued to increase even after 40 years since the last exposure. The information gathered was also useful in that it identified the types of asbestos that put patients at greatest risk, with blue asbestos, or crocidolite carrying the highest levels of danger and workers who had been exposed to a combination of several different types of asbestos being at a risk five times greater than of those who were exposed to chrysotile asbestos alone.

Theories as to why asbestos behaves so differently from other toxins abound, but the most frequently posited notion has to do with the physical properties of asbestos itself. Unlike nicotine or other inhaled chemicals, asbestos fibers are pointy and sharp. They become embedded in the cells of the body and remain there rather than being expelled. This means that they continue to have the potential for causing mutations and inflammation decades after the fiber is originally inhaled or ingested.

If you have been exposed to asbestos and are concerned about your own risk of being diagnosed with mesothelioma, or if someone you love has already been diagnosed with the disease, you need information on signs, symptoms, and resources that are available to you. At Mesothelioma.net, we are dedicated to providing asbestos exposure victims with the help that they need. Call our Patient Advocates today at 1-800-692-8608, or visit our website at http://www.mesothelioma.net.

Terri Oppenheimer is an independent writer, editor, and proofreader. She graduated from the College of William and Mary with a degree in English. Her dreams of a writing career were diverted by a need to pay her bills. She spent a few years providing the copy for a major retailer, then landed a lucrative career in advertising sales. With college bills for all three of her kids paid, she left corporate America for a return to her original goal of writing. She specializes in providing content for websites and finds tremendous enjoyment in the things she learns while doing her research. Her specific areas of interest include health and fitness, medical research, and the law.

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Polish Study Confirms That Mesothelioma Risk Only Increases With … – Mesothelioma.net Blog (blog)

Nintedanib Combination Delayed Progression in Malignant Mesothelioma – Cancer Network

Adding nintedanib to pemetrexed/cisplatin improved the progression-free survival (PFS) of patients with malignant pleural mesothelioma compared with placebo, according to updated results (abstract 8506) presented at the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting.

Nintedanib is an oral multikinase inhibitor that targets vascular endothelial growth factor receptors 13, platelet-derived growth factor receptors /, fibroblast growth factor receptors 13, and Src and Abl kinase signaling. Patients treated with nintedanib on this trial had a median PFS (the primary endpoint) gain of 3.7 months compared with placebo.

This study met its primary endpoint and demonstrated clinical benefit in first-line treatment in patients with mesothelioma with the addition of nintedanib to pemetrexed and cisplatin, said Anna K. Nowak, MD, of the University of Western Australia, who presented the results.

According to Nowak, mesothelioma is often diagnosed at an advanced stage. Pemetrexed/cisplatin is the only approved regimen for this disease, providing a median overall survival of about 1 year.

Data from the primary analysis of this trial showed that nintedanib improved PFS (hazard ratio [HR], 0.56; 95% CI, 0.340.91) compared with placebo. At the meeting, Nowak presented updated PFS and mature overall survival results.

The trial included 87 patients with unresectable mesothelioma who were randomly assigned to 6 cycles or less of pemetrexed/cisplatin plus nintedanib or placebo followed by nintedanib or placebo monotherapy until progression.

Results from the updated analysis showed a median PFS of 5.7 months for placebo compared with 9.4 months for nintedanib (HR, 0.54; 95% CI, 0.330.87; P = .010). In a preplanned subgroup analysis of patients with epithelioid histology, the median PFS increased from 5.7 months with placebo to 9.7 months with nintedanib (HR, 0.49; 95% CI, 0.300.82; P = .006).

There was no significant difference in overall survival between the two treatment arms (HR, 0.77; 95% CI, 0.461.29; P = .319). The median overall survival increased from 14.2 months in the placebo arm to 18.3 months in the nintedanib arm, but the difference was not statistically significant. In patients with epithelioid histology, the median overall survival was 20.6 months for nintedanib compared with 15.2 months for placebo (HR, 0.70; 95% CI, 0.401.21; P = .197).

Finally, the objective response rate was 57% in the nintedanib arm compared with 44% in the placebo arm (odds ratio, 1.66; 95% CI, 0.723.92).

There was substantially more neutropenia and thrombocytopenia in the nintedanib arm. In addition, diarrhea and abnormalities in liver function were also more common in the nintedanib arm. However, Nowak noted that few of the diarrhea events were grade 3 or higher. Four fatal serious adverse events occurred on the studyone in the nintedanib arm and three in the placebo armbut all were related to disease progression.

A phase III study of this regimen is ongoing.

Link:

Nintedanib Combination Delayed Progression in Malignant Mesothelioma – Cancer Network

Mesothelioma Risk Continues to Rise for Decades After Asbestos Exposure – Surviving Mesothelioma

A pair of Polish researchers have confirmed what a number of other studies have suggested that the risk of contracting malignant mesothelioma continues to rise, even decades after a persons last exposure to asbestos.

The study was conducted by asbestos-exposure experts at the Nofer Institute of Occupational Medicine and included a total of 131 patients with pleural mesothelioma.

Another 655 people enrolled in a health surveillance program for asbestos-related diseases between 2000 and 2014 were included as controls.

When researchers Beata Swiatkowska and Neonila Szeszenia-Debrowska used the data to calculate the odds that asbestos-exposed people would develop malignant mesothelioma, the results were sobering.

Instead of declining over time, the chance that an asbestos-exposed worker would receive a diagnosis of mesothelioma continued to climb, the further he or she got from their last asbestos exposure.

The results show that the risk of pleural mesothelioma continued to increase even after 40 years since the last exposure, states the report. In fact, the people who had last been exposed to asbestos 4 decades ago were more than two-and-a-half times as likely to contract mesothelioma as those whose last exposure was just 5 years ago.

Another key observation from the new mesothelioma study is that the type of asbestos to which a person is exposed may also impact their risk of contracting pleural mesothelioma.

While all types of asbestos have been shown to cause mesothelioma, the Polish study found that the risk was very high in people who worked around crocidolite or blue asbestos. The risk of mesothelioma was also 5 times higher in workers who were exposed to a mixture of different types of asbestos than it was in those who were only exposed to chrysotile asbestos.

The researchers say an understanding of the dose-response relationship in occupationally-exposed people could be helpful in the study of mesothelioma risk among people exposed to asbestos in their environments.

Asbestos is a naturally-occurring mineral that was used for decades in a variety of industrial and construction applications. Although many countries have now banned its use, the incidence of mesothelioma, the most deadly disease associated with asbestos exposure, has continued to rise.

One big reason for this rise is the biopersistence of asbestos, the sharp fibers of which stay in the body indefinitely after exposure, triggering cancer-caused inflammation at the cellular level. Although multi-modal treatments have modestly increased mesothelioma survival rates, there is no cure.

Source:

Swiatkowska, B and Szeszenia-Dabrowska, N, Mesothelioma continues to increase even 40 years after exposure Evidence from long-term epidemiological observation, June 2017, Lung Cancer, pp. 121-125

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Mesothelioma Risk Continues to Rise for Decades After Asbestos Exposure – Surviving Mesothelioma

Peritoneal Cancer Index: What it Means for Mesothelioma Patients – Mesothelioma & Asbestos Awareness Center (blog)

Cancer in the abdomen, or peritoneal cancer, is very rare. It occurs when cancer cells develop on the peritoneum, the thin cell lining of the abdominal organs. About 10 30% of peritoneal cancer cases occur following a gastric or colon cancer diagnosis. Very rarely this type of cancer will develop on its own, and even then it is often the result of metastasis after a tumor forms elsewhere in the body.

Similarly to peritoneal cancer, peritoneal mesothelioma is very rare, accounting for about 500 new cases each year and only about 15 20% of mesothelioma diagnoses. Unlike most forms of peritoneal cancer, peritoneal mesothelioma is not known to be caused by other forms of cancer or the result of metastasis. All types of mesothelioma are caused by exposure to asbestos, through inhalation or ingestion.

Oncologists for peritoneal cancers have relied on the Peritoneal Cancer Index (PCI) for years to help determine a patients eligibility for certain kinds of treatment, as well to better understand the severity of the tumors progression. PCI has become a notable tool when facing peritoneal mesothelioma, which typically has a poor prognosis and is very often fatal.

PCI is a way to determine the extent of the cancer in the abdominal cavity. The cavity is divided into 13 distinct sections, including central, left upper, and pelvic. Each region is ranked separately with a lesion size (LS) score depending on the size of the tumors present.

Patients with an LS score of 3 in a particular region may also have layers or multiple small nodules present. PCI itself is found by adding together the scores for the 13 regions, which makes the highest PCI a 39. Oncologists can determine their score for each region through various imaging tests or laparoscopy. For peritoneal mesothelioma patients, a diagnosis will first need to be confirmed through a peritoneoscopy or laparotomy, which is a tissue biopsy. Doctors will scrutinize the samples to determine the cell type and help examine if the cancerous cells have spread.

PCI is essentially a staging system for peritoneal cancers to help determine if the cancer is localized or has spread to other organs or lymph nodes. Typically, the higher the PCI indicates a worse prognosis as this indicates more, larger tumors present in the body. The PCI will also help oncologists determine if a patient is eligible for certain treatments, particularly surgical removal of the tumors or Hyperthermic Intraperitoneal Chemotherapy (HIPEC).

A good or lower PCI for peritoneal mesothelioma patients can mean a better chance of long-term survival. Most oncologists have a cut off score to determine what kind of treatments the patient may be eligible for. In general, a PCI greater than 20 is thought to be too high to see any effective results from HIPEC and the patients would face greater risk undergoing this treatment.

While patients with peritoneal mesothelioma have a longer life expectancy than the other types of mesothelioma, the median survival is still only one year. All types of mesothelioma are generally treated with a combination of surgery, chemotherapy, and radiation. For peritoneal mesothelioma, some of the best results have been seen with a multimodal approach of cytoreductive surgery (surgery to remove as much of the tumors as possible) and HIPEC.

HIPEC is a method of delivering a heated chemotherapy wash to the abdominal cavity. Its meant to ideally clean out any remaining cancer cells after surgery. HIPEC has been used to treat other abdominal cancers too, including colon and ovarian cancer.

According to a recent study, approximately two-thirds of the peritoneal mesothelioma patients treated this way survived over 3 years. While this may not seem very long, its significantly longer than the 1 year median survival rate. In general, there are very few long-term mesothelioma survivors regardless of the type, with only about 33% of patients surviving a year after diagnosis. Any treatment or tool that can better the survival rate is a big accomplishment.

Researchers recognize the advancements in the combination of surgery and HIPEC as the reason for improved survivorship among peritoneal mesothelioma patients in more recent years. Using PCI can make it easier for oncologists to determine the effectiveness of this treatment for an individuals case.

In the past decade, researchers have made a lot of great advancements in better diagnosing and treating mesothelioma. The peritoneal cancer index is just one tool that can help researchers and peritoneal mesothelioma patients better understand the stage of their disease and the available treatment options.

There is still a lot of work ahead to more effectively treat, and one day cure, this aggressive cancer. But hopefully with the help of established tools like PCI and the advancements made in research today, we will get there soon rather than later.

Link:

Peritoneal Cancer Index: What it Means for Mesothelioma Patients – Mesothelioma & Asbestos Awareness Center (blog)

Remembering Mesothelioma Victims in the UK – Mesothelioma.com (blog)

Even though the United Kingdom officially banned asbestos in 1999, the toxin continues to claim lives. Though no new uses or imports of the mineral are allowed, it still remains in many schools and older buildings causing many to unknowingly be exposed. Since there is a long latency period after exposure before symptoms appear, millions are still at risk to develop mesothelioma and other asbestos-caused diseases in their lifetime.

In 2014, there were 2,717 new cases of mesothelioma in the UK. This number is on par with the number of new cases each year in the United States, where asbestos is still not banned. While it is a rare disease and the number of cases may not appear alarmingly high, the incidence rate in the UK has increased by 71% since the 1990s. Mesothelioma is preventable, and theres still a lot more work to be done worldwide to save lives from asbestos.

Over the years, the UK has said goodbye to several well-known talents because of this rare disease. For many of them, its uncertain how they were exposed to the toxin, which shows the continued importance of raising awareness for this mineral and the dangerous diseases it can cause.

George Hunt was a footballer from Swindon. At the young age of 14, he dropped out of school and began working at the Great Western Railway Works, also known as Swindon Works. After serving in the Army during World War II, Hunt had the opportunity to play football professionally and joined the Swindon Town Club. He made his debut in 1947 and played over 300 games before retiring in 1958. Hunt returned to Swindon Works fulltime and coached soccer occasionally on the side.

Unfortunately, his time at Swindon Works led to his devastating diagnosis. Railroad workers were frequently exposed to asbestos, as the mineral was used widely throughout the train because of its heat resistance. Over such a long career at the railroad, Hunt faced prolonged exposure to the toxin, which greatly increased his chances of developing mesothelioma.

So many workers at Swindon Works were exposed and ultimately diagnosed with mesothelioma that they sometimes referred to this rare cancer as Swindons disease. Hunt was diagnosed with peritoneal mesothelioma and passed away in 1987.

Dame Ann Ebsworth was a barrister and judge of the High Court. She was appointed to the High Court in 1992, becoming the first woman to ever be appointed to the queens bench division. At the time, she was only one of four women among the over 100 justices at the High Court. Ebsworths first priority was justice, and her colleagues lauded her for her fairness. She aimed high throughout her career and earned appointments in many courts of law.

Unfortunately, her successful career in the courtroom ended in early retirement shortly after she was diagnosed with peritoneal mesothelioma in 2000. Despite growing weaker, she continued to teach students who needed help and advocate the importance of justice.

Ebsworth was likely exposed to asbestos throughout her childhood, as she grew up in a military family. Her father served as an officer in the Royal Marines, and the family frequently traveled to different barracks. Asbestos was frequently used throughout the military, on various vessels and in buildings on base. Veterans make up a large proportion of mesothelioma diagnoses, and Ebsworth likely had secondhand asbestos exposure from her fathers various interactions with the mineral.

Science fiction writer Michael Coney had his first story published in 1969 in a science fiction magazine, with several other short stories published in British and American publications shortly after. Throughout the 1970s, Coney established himself as one of the leading British science fiction writers, which many of his critics owe to his move to the West Indies for a fresh start.

Though critics claim his period of intense creativity ended when his family moved to Canada, his novels and short stories were still loved by his audience and critics alike. Some of his most beloved work include his novels Mirror Image and Glass Children.

It remains unclear how Coney was first exposed to asbestos which later led to a pleural mesothelioma diagnosis. In his last interview, Coney described how debilitating the disease was and how he struggled with his concentration. He said handling the disease took over his ability to write. When he was diagnosed, Coney decided to release his latest short stories for free online. His last novel, I Remember Pallahaxi, was published posthumously in 2007.

Christie Hennessy was an Irish folk singer and songwriter, though he suffered from severe dyslexia which made him unable to read or write. His most famous song, Dont Forget Your Shovel, has often been described as an alternative national anthem for Ireland.

Hennessy realized his exposure to the toxin occurred as a result of his work in London as a painter and decorator. He worked with this company from the young age of 15, and likely faced prolonged exposure from the different buildings and jobsites he worked in.

He was later diagnosed with pleural mesothelioma, and sadly died at a London hospice at just 62. At the time, Hennessy had been working on new music and planning a tour. His wife, Gill Ross, recognized their legal rights and decided to pursue action against his employer for their negligence which ultimately led to the singers death. With the help of qualified mesothelioma lawyers, they were able to reach a settlement to assist with the high medical costs associated with the disease.

John MacDougall was a Member of Parliament from 2005 until his death for Glenrothes. He previously served in the House of Commons for Central Fife after the 2001 election. Before he began his career in politics, MacDougall worked in shipyards. He first started caulking riveters and eventually transitioned to work at an oil rig as a boilermaker.

His asbestos exposure certainly occurred during his career before he transitioned to politics. Boilermakers were frequently exposed to airborne asbestos because of the nature of their work, especially when repairing older boilers that likely had damaged asbestos insulation.

MacDougall was diagnosed with malignant pleural mesothelioma in 2007. In later years, he revealed the severity of his disease, explaining he had his lung removed in the hopes of removing the cancer. In later interviews, his daughter Julie explained his decline was rapid, but he never gave up hope. After his passing, Julie created the John MacDougall Mesothelioma Trust in his honor in 2010. Their goals are to raise awareness for this rare disease and help support important mesothelioma research to hopefully one day find a cure.

Ian Cundy served as the Bishop of Peterborough from 1996 until his death. He was held in high regard for his education and varied skills. Throughout his career, Cundy strived to create better unity in the church. He is particularly known for his support of female priests, which created some tension with other church members.

He was diagnosed with pleural mesothelioma in 2007, and by 2008 announced his plans to retire early because of the severity of his disease. Although he underwent chemotherapy, the aggressive cancer rapidly spread. Ian passed away shortly after collapsing at a family event. His wife, Jo, released a book in 2014 about their life together and her journey in letting him go.

Though asbestos is banned in the UK, there is still a lot of work to be done to help change the statistics and better prevent mesothelioma.

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Remembering Mesothelioma Victims in the UK – Mesothelioma.com (blog)

Steve McQueen’s Wife Pushes for Asbestos Ban – Mesothelioma.com

Jillian Duff covers pressing news for the Mesothelioma Cancer Alliance. Bio

June 20, 2017

Washington, D.C. – Barbara Minty McQueen, wife of the late actor and mesothelioma victim Steve McQueen, continues to create awareness and fight for an asbestos ban in the name of her film icon husbands legacy. Steve McQueen died of mesothelioma cancer at 50 years old.

Steve McQueen grew up in Indiana, and at one point during his service in the U.S. Navy, he met Barbara Minty and ran off with her. When the tryst was discovered, he was made to scrub the inside of a submarine from top to bottom. Its believed thats when the asbestos exposure occurred with flakes flying everywhere as he cleaned.

Asbestos doesnt only affect blue-collar workers. Housewives, Congressmen, movie stars, rock stars, and everyone else can be exposed. Even Hollywood film industry professionals have fallen victim to mesothelioma. Fake snow, special effect boards, piping, and curtains containing asbestos were used on numerous sets throughout history.

Barbara McQueen is a presenter at the 2017 Harvest America Festival to be held in the University of Phoenix stadium. Almost 63,000 people will be in attendance, and the speech will be broadcast to millions of viewers around the world.

According to Barbara McQueen, Steve once said, When I believe in something, I fight like hell for it. Thats why shes also written a new book titled Steve McQueen: the Salvation of an American Icon with Marshal Terrill, coauthor of Barbara McQueens first book, and Greg Laurie, founder of the Harvest Christian Fellowship.

Barbara McQueen has also published Steve McQueen: The Last Mile. It discusses the couples three-and-a-half-year relationship before he passed.

The revised edition of the book includes a page for mesothelioma information and talks about the Asbestos Disease Awareness Organization to share more on the deadly effects of asbestos. Many international conference attendees and even Michelle Obama have been presented with the book.

Asbestos is still not banned in the U.S. American businesses legally import, use, and sell both raw asbestos and products made with it today. Hundreds of thousands of pounds enter the country each year, according to the EWA Action Fund.

I think he would think thats wonderful. That he could use his death, his celebrity, for something to help people open their eyes, said Barbara McQueen. I think hed be proud to be a part of it.

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Steve McQueen’s Wife Pushes for Asbestos Ban – Mesothelioma.com

Mesothelioma Causes – Mayo Clinic

In general, cancer begins when a series of genetic mutations occur within a cell, causing the cell to grow and multiply out of control. It isn’t clear what causes the initial genetic mutations that lead to mesothelioma, though researchers have identified factors that may increase the risk. It’s likely that cancers form because of an interaction between many factors, such as inherited conditions, your environment, your health conditions and your lifestyle choices.

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Mesothelioma Causes – Mayo Clinic

Mesothelioma Lawyer | Law Offices of Peter Angelos, P.C.

The Law Offices of Peter Angelos, P.C. has been Marylands leading mesothelioma and asbestos victims law firm for over 50 years. Our attorneys have recovered significant compensation on behalf of thousands of working men, women, and families affected by this disease – and we’re prepared to fight for you.

If you or a loved one has been exposed to asbestos, or are suffering from mesothelioma or other asbestos-related diseases, our mesothelioma lawyers can help you pursue legal recourse to recover your damages.

To learn more about mesothelioma, asbestos exposure, and your legal rights, fill out a free case evaluation form.

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Mesothelioma Lawyer | Law Offices of Peter Angelos, P.C.

Nurse Explains Mesothelioma Staging – MesotheliomaHelp.org (blog)

Staging of a persons cancer is done for many different reasons. According to the American Cancer Society, staging is defined as: The process of finding out how much cancer is in the persons body and where it is located. Its how the doctor determines the stage of a persons cancer. For mesothelioma, there have been various different staging systems put in place over the years at different institutions. This sometimes leads to confusion regarding the language, a patients prognosis, and for scientists hoping to speak a common language when collaborating.

Most cancers are staged using the TNM classification system. T stands for the primary tumor, N stands for the lymph nodes- whether the cancer has spread to nearby lymph nodes, M stands for metastasis, whether the cancer has spread to distant parts of the body. Each of these three classifications- T, N, M is then broken down with more descriptive information. Once the extent of the T, N, M classifications have been determined, they are then assigned an overall stage. There are also other factors that affect the stage, including the grade- how the cells look under the microscope, cell type, location, and tumor marker levels. Once cancer is staged it always remains the same. If you are diagnosed with Stage 2 cancer, it will always be referred to as Stage 2 even if it goes into remission, or metastasizes to other organs.

For many years, mesothelioma experts did not have a defined staging system exclusively to describe mesothelioma. A mesothelioma expert once said mesothelioma is so rare just having the diagnosis of mesothelioma, at an earlier point in time, would have gottenyou into a mesothelioma clinical trial.

As testimony to progress, a group led by Dr. Valerie Rusch of the Memorial Sloan Kettering Cancer Center, in conjunction with the International Mesothelioma Interest Group, and other organizations has defined a new staging system for pleural mesothelioma. The importance of mesothelioma staging system is uniformity in describing the disease. The effect of various treatment options can be studied and perfected for the different types of pleural mesothelioma.

More evidence that the treatment of mesothelioma is being advanced on many fronts and further work towards a potential cure!

If you have questions about your mesothelioma treatment or any aspect of your mesothelioma care, please email me at LHyde-Barrett@mesotheliomahelp.net.

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Nurse Explains Mesothelioma Staging – MesotheliomaHelp.org (blog)

5 Questions: Treatment options exist for mesothelioma – Las Vegas Review-Journal

We asked Dr. Raja Flores, an expert in the study and treatment of malignant pleural mesothelioma, about this aggressive form of lung cancer. Flores is based at Mt. Sinai in New York City and over the years has published information for mesothelioma patients and caregivers at the Mesothelioma Cancer Alliance mesothelioma.com the national online resource center focused on raising awareness of the dangers of asbestos and information on related cancers.

Review-Journal: What is mesothelioma and what causes it?

Flores: Mesothelioma is a rare, aggressive disease that affects the linings of the lungs and abdomen. The vast majority of mesothelioma cases are caused by exposure to asbestos and can take anywhere from 20 to 50 years to show symptoms. After rigid asbestos fibers are inhaled, they can get stuck in the the lining of the lung, where inflammation and tumors can develop.

What percentage of people who are diagnosed with mesothelioma die from it?

I dont like to use percentages because those figures are for comparing patient populations. The percentages of people who are diagnosed vary depending on what studies you look at. Unfortunately, a majority of mesothelioma patients will die of their disease. However, there are many treatment options to improve and extend the length of ones life. Each patient should be looked at as an individual with different prognostic factors that will influence his or her survival.

What treatment options are available?

Surgery is the mainstay of treatment for mesothelioma, followed by chemotherapy or radiation or both depending on the intraoperative findings. Palliative treatment is recommended to ease symptoms and improve ones quality of life. New experimental treatments like immunotherapy and clinical trials are being worked on every day in hopes of finding a cure.

What resources are available for patients and caregivers in Las Vegas?

Las Vegas has a great cancer center (Nevada Comprehensive Cancer Center) with one of the best medical oncologists for mesothelioma, Dr. Nicholas Vogelzang. Also, patients are encouraged to travel to other mesothelioma specialists in New York or Boston for second opinions. Each individual is unique, and the best options are different for each person.

What suggestions do you have for people who might have had asbestos exposure in the past?

My suggestion would be to obtain a low dose screening CT scan to look for obvious signs of asbestos exposure in the lungs. Exposure to asbestos not only causes mesothelioma, but asbestos-related lung cancer and progressive asbestosis fibrosis that can lead to these illnesses mentioned and serious health concerns.

If you are a medical professional who would like to be considered for this feature, send your name, a brief explanation of your expertise and your contact information to health@reviewjournal.com.

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5 Questions: Treatment options exist for mesothelioma – Las Vegas Review-Journal

Can a Breath Test Diagnose Mesothelioma in the Early Stages? – Asbestos.com

Much of mesothelioma research centers on identifying new and noninvasive biomarkers for earlier detection of the asbestos-related cancer.

Progress has been made in finding biomarkers in blood and pleural effusions, but researchers in Belgium now believe the next breakthrough in early diagnosis for mesothelioma cancer may be a breath test.

Researchers at Ghent University Hospital and Antwerp University Hospital recently highlighted the potential of breath analysis, called breathomics, as a noninvasive screening tool for malignant pleural mesothelioma. The Oncotarget medical journal published the study in May.

Breath tests or electronic noses are not a new innovation, but the science behind them especially as an early detection device for cancer is improving.

The tool uses spectrometric, chromatographic and sensor techniques to identify organic molecules in breath as biomarkers. There are still challenges, including improving effectiveness and ease-of-use, lowering test-related costs and shortening the time for achieving an analytical result.

There is also a need for more clinical studies with larger patient cohorts.

But breath tests seem to be the most promising avenue for early detection. Current mesothelioma screening tools generally detect the cancer in advance stages.

We believe a breathomics-based biomarker approach should be further explored to improve the follow-up and management of asbestos exposed individuals, lead researcher Sabrina Lagniau wrote in the study. We aim to develop breath analysis as a point-of-care biomarker test that meets these requirements.

Mesothelioma, much like other cancers, is best treated in the early stage.

But the rarity of the cancer, along with symptoms that mirror less serious conditions, makes early detection difficult. Most diagnoses occur after symptoms become severe, when the cancer has progressed so much that treatments usually focus on improving a patients quality of life rather than substantially extending it.

In the recent study, Lagniau and her team highlight shortcomings of blood and fluid based biomarkers.

Studies addressing the accuracy in mesothelioma patients versus healthy controls are redundant, as are studies restricted to pleural effusions, as the latter are obtained in patients who have already a high likelihood of [malignant pleural mesothelioma], Lagniau wrote.

Lagniaus team believes the focus should turn to people with a history of asbestos exposure with no signs of asbestos-related health conditions.

High-risk individuals can be monitored with breathomics, and if they are later diagnosed with mesothelioma or another asbestos-related disease, researchers can better determine the biological changes that occurred.

While this wont prevent the development of mesothelioma, it could potentially lead to detection before symptoms appear, when the cancer is localized and more life-extending treatment options are possible.

It could revolutionize the diagnostic process, which now relies on imaging tests and biopsies.

Cancer is a disease that affects people in every layer of society and we, scientists, have the obligation to use our knowledge on human health in exploring new ways to improve cancer management, Lagniau wrote. Therefore, future studies should focus on the at-risk population, consisting of people being [occupationally] exposed to asbestos with a latency time of at least 20 years after exposure.

There is still no gold standard for breath analysis in regard to early detection of malignancies.

Currently, the best option is gas chromatography-mass spectrometry (GC-MS), known for its high sensitivity and ability to identify and quantify individual compounds.

But downsides of GC-MS, as Lagniau points out, include its relative cost, requirement for expert operation and the amount of time it takes to get a result.

Other breath analysis tools such as electronic noses (e-noses) or selected ion flow tube mass spectrometry allow for real-time results, but also come with shortcomings, including decreased sensitivity.

Volatile organic compounds (VOCs) may be used as a potential diagnostic biomarker to screen mesothelioma and other cancers. The Belgian research team believes if cancer-specific VOCs can be identified, e-noses can be refined to detect them.

With this strategy, the specificity of an e-nose will be higher than that of the standard, more complex technologies, Lagniau wrote.

There is still plenty of work to be done, but Lagniau feels research is moving in the right direction.

Research that focuses on breath biomarkers in [malignant pleural mesothelioma] is in its early days, but the few studies that have been performed show promising results.

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Can a Breath Test Diagnose Mesothelioma in the Early Stages? – Asbestos.com

Mesothelioma Compensation Center Now Urges an Electric Utility Worker or Electrician with Mesothelioma to Aim High … – PR Newswire (press release)

NEW YORK, June 21, 2017 /PRNewswire/ –The Mesothelioma Compensation Center is now urging an electrical worker or any electrician who has recently been diagnosed with mesothelioma to call anytime at 800-714-0303 for access to two or three of the nation’s most skilled, experienced, and capable mesothelioma attorneys. The group’s number one goal for people with mesothelioma is to get the best possible financial compensation. This might explain why they are so passionate about a person with mesothelioma hiring the absolute top mesothelioma attorneys in the nation. http://MesotheliomaCompensationCenter.Com

An electrician or electrical worker could have had exposure to asbestos by having contact with the following products:

The Mesothelioma Compensation Center says, “The reason the financial compensation for an electrical worker or electrician can be so significant is because prior to 1980 the individual most likely had non-stop exposure to asbestos. The only work groups that could have had equal or more exposure to asbestos would be a US Navy Veteran, shipyard worker, plumber, insulator, or welder.

“If we had one vital tip for an electrical worker or electrician with mesothelioma it would be call us at 800-714-0303 to ensure you have the nation’s top mesothelioma attorneys working on your financial claim.

“We recommend the nation’s most skilled and qualified mesothelioma attorneys because these experts produce the best financial compensation results for their clients nationwide. We want people with mesothelioma to get the best compensation, but to do so they will need to team up with the nation’s top mesothelioma attorneys as we would like to discuss.” http://MesotheliomaCompensationCenter.Com

For a listing of most major electrical utility companies in the United States please refer to the following website: http://www.bestenergynews.com/solar/utility_co/utility_companies.php.

The Mesothelioma Compensation Center specializes in assisting specific types of people who have been diagnosed with mesothelioma. The Center’s top priority is assisting US Navy Veterans, shipyard workers, oil refinery workers, public-utility workers, chemical plant workers, manufacturing workers,power plant workers,plumbers, welders,electricians, millwrights, pipefitters, boiler technicians, machinists, nuclear power plant workers, hydro-electric workers or oil and gas field production workers who have been diagnosed with this rare cancer caused by asbestos exposure. In most instances a diagnosed person with mesothelioma was exposed to asbestos in the 1950’s, 1960’s, 1970’s, or 1980’s. http://MesotheliomaCompensationCenter.Com

According to the CDC the states indicated with the highest incidence of mesotheliomainclude Maine, Massachusetts, Connecticut, Maryland,New Jersey, Pennsylvania, Ohio, West Virginia, Virginia,Michigan, Illinois, Minnesota, Louisiana, Washington, and Oregon. However, an electrician or electric utility worker with mesothelioma could live in any state including California, New York, Florida,Texas,Illinois,Kentucky, Tennessee, Mississippi, Georgia,Alabama, Wyoming, Colorado, New Mexico, Nevada,Utah, Arizona, Idaho, or Alaska.

The average age for a diagnosed victim of mesothelioma is about72 years old. This year between 2500, and 3000 US citizens will be diagnosed with mesothelioma. US Navy Veterans comprise about one-third of all people who will be diagnosed with mesothelioma each year in the United States.

The Mesothelioma Compensation Center says, “Before you hire a law firm to advance a mesothelioma compensation claim for yourself or a family member please call us anytime at 800-714-0303 to ensure you are talking directly to the nation’s very best mesothelioma attorneys.” http://MesotheliomaCompensationCenter.Com

For more information about mesothelioma please refer to the National Institutes of Health’s web site related to this rare form of cancer: http://www.nlm.nih.gov/medlineplus/mesothelioma.html

Contact: Michael Thomas 8007140303 163147@email4pr.com

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/mesothelioma-compensation-center-now-urges-an-electric-utility-worker-or-electrician-with-mesothelioma-to-aim-high-for-compensation-and-to-call-about-specific-lawyers-to-help-300477338.html

SOURCE Mesothelioma Compensation Center

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Mesothelioma Compensation Center Now Urges an Electric Utility Worker or Electrician with Mesothelioma to Aim High … – PR Newswire (press release)


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