Foundation Medicine Launches FoundationOneā„¢

CAMBRIDGE, Mass.--(BUSINESS WIRE)--

Foundation Medicine announced today the commercial launch of FoundationOne, the first pan-cancer, fully informative genomic profile designed to help oncologists expand their patients treatment options. FoundationOne is optimized to fit current oncology practice. It uses clinical-grade, next-generation sequencing to interrogate hundreds of cancer-related genes from routine, formalin-fixed, paraffin-embedded tumor samples. Test results are provided in a straightforward report that aligns detected genomic alterations with potential treatment options and clinical trials.

The launch of FoundationOne marks an important moment in the field of oncology, said Michael J. Pellini, M.D., Foundation Medicines chief executive officer. This first commercial product from Foundation Medicine is the result of a convergence of genomic sequencing, information technology and clinical practice that would not have been possible at any other point in history. Foundation Medicine is the first company with the ability to put these advances into everyday care, giving oncologists the molecular blueprint of each patient's cancer to help inform a more targeted treatment strategy.

FoundationOne interrogates all genes somatically altered in human solid tumors that are validated targets for therapy or drivers of oncogenesis based on current knowledge. It reveals all classes of genomic alterations, including base substitutions, insertions, deletions, copy number alterations and select rearrangements. Genomic profile results are reported to the physician for each individual patient along with targeted therapies and clinical trials that may be relevant based on the specific alterations identified in the patients tumor and the most recent scientific and medical evidence.

FoundationOne brings a best-in-class molecular diagnostic to all oncologists and pathologists, both in the community where most patients are treated and at major academic centers, said Vincent Miller, M.D., senior vice president of clinical development, Foundation Medicine. FoundationOne gives physicians a powerful new tool to help them incorporate the latest genomic findings into treatment decisions for each patient. The commercial availability of FoundationOne is perfectly timed to accelerate the clinical adoption of the burgeoning molecular information in oncology.

Early clinical studies with FoundationOne have demonstrated high accuracy and an ability to interrogate all classes of potentially actionable alterations to reveal clinically-relevant information1-2. Since receiving CLIA certification in October, 2011 and beginning pre-launch operations, Foundation Medicine has shown that FoundationOne reveals, on average, approximately three reportable alterations per patient sample and three times as many actionable alterations than the most comprehensive hot spot panels or tests currently available3. FoundationOne sequences hundreds of genes known to be clinically relevant in cancer and identifies any actionable alterations, whereas existing technologies are able to find only pre-determined alterations. Experience to-date shows that FoundationOne can identify previously undetectable, yet potentially actionable, alterations, and suggests that FoundationOne will profoundly increase the application of molecular information in clinical practice.

Foundation Medicine was founded in 2010 by world leaders in the fields of cancer genomics, cancer biology, clinical oncology, and information sciences from Harvard Medical School, Massachusetts Institute of Technology, The Dana-Farber Cancer Institute and The Eli and Edythe L. Broad Institute. The company is funded by Third Rock Ventures, Kleiner Perkins Caufield & Byers and Google Ventures.

About FoundationOne

FoundationOne is a fully informative genomic profile that complements traditional cancer decision tools and often expands treatment options by matching patients with targeted therapies that may be relevant to the molecular changes in their tumor. Using next-generation sequencing, FoundationOne interrogates all genes somatically altered in human cancers that are validated targets for therapy or drivers of oncogenesis based on current knowledge. It reveals all classes of genomic alterations including base substitutions, insertions, deletions, copy number alterations and select rearrangements. Each patients genomic profile is reported to the physician matched with targeted therapies and clinical trials that may be relevant based on the molecular blueprint of their tumor. Results are supported by the latest scientific and medical evidence. FoundationOne has been optimized to fit easily into the clinical workflow of a practicing oncologist. It is available for all solid tumors and clinical grade results can be obtained from as little as 50ng of DNA obtained from formalin-fixed, paraffin-embedded tumor tissue samples. FoundationOne is a laboratory-developed test performed at Foundation Medicines CLIA-certified facility and is currently available for all solid tumor types. Please visit http://www.foundationone.com for more information.

About Foundation Medicine

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Foundation Medicine Launches FoundationOneā„¢

Naturopathic medicine fits into the medical mainstream

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Naturopathic medicine fits into the medical mainstream

Perelman School of Medicine Student Named Albert Schweitzer Fellow

Katie Murphy, a graduate student in Human Development and Public Health, Perelman School of Medicine and University of Pennsylvania's Graduate School of Education, was selected as a 2012 Greater Philadelphia Schweitzer Fellow by The Albert Schweitzer Fellowship (ASF). Murphy's fellowship will fund her work which aims to strengthen health navigation skills and improve knowledge of child development among undocumented Mexican immigrants living in South Philadelphia.

Working with Puentes De Salud's women's groups, Murphy will help develop a curriculum on child health and development.

"Throughout the application and interview process, Katie's clear track record of working with underserved populations impressed our selection committeeas did her well-articulated, specific, and measurable approach to addressing the social determinants of health," said Nicole Moore, Director, Greater Philadelphia Schweitzer Fellows Program. "Additionally, with her international experience, previous leadership roles, and demonstrated interest in interdisciplinary learning, it was clear that Katie would bring a unique and enriching perspective to this year's group of Fellows."

Kara Cohen, a graduate student at University of Pennsylvania's School of Nursing, was also selected as a Fellow in this year's class. Cohen's research responds to the podiatric needs of homeless individuals in Philadelphia at the Ridge Avenue Men's Shelter. A full news release on Cohen's research is available here.

The approximately 240 Fellows selected nationwide will all help carry out ASF's mission by pursing service projects targeting health issues in underserved communities. After completing the yearlong fellowship, the students become Schweitzer Fellows for Life, joining nearly 2,500 others trained and dedicated to responding to the health needs of underserved people.

###

Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4.3 billion enterprise.

The Perelman School of Medicine is currently ranked #2 in U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $479.3 million awarded in the 2011 fiscal year.

The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top 10 hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; and Pennsylvania Hospital the nation's first hospital, founded in 1751. Penn Medicine also includes additional patient care facilities and services throughout the Philadelphia region.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2011, Penn Medicine provided $854 million to benefit our community.

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Perelman School of Medicine Student Named Albert Schweitzer Fellow

Research and Markets: Biomedical Engineering. Bridging Medicine and Technology

DUBLIN--(BUSINESS WIRE)--

Research and Markets (http://www.researchandmarkets.com/research/fzcbmx/biomedical_enginee) has announced the addition of the "Biomedical Engineering. Bridging Medicine and Technology" report to their offering.

This is an ideal text for an introduction to biomedical engineering. The book presents the basic science knowledge used by biomedical engineers at a level accessible to all students and illustrates the first steps in applying this knowledge to solve problems in human medicine. Biomedical engineering encompasses a range of fields of specialization including bioinstrumentation, bioimaging, biomechanics, biomaterials, and biomolecular engineering. This introduction to bioengineering assembles foundational resources from molecular and cellular biology and physiology and relates them to various sub-specialties of biomedical engineering. The first two parts of the book present basic information in molecular/cellular biology and human physiology; quantitative concepts are stressed in these sections. Comprehension of these basic life science principles provides the context in which biomedical engineers interact. The third part of the book introduces sub-specialties in biomedical engineering, and emphasizes - through examples and profiles of people in the field - the types of problems biomedical engineers solve.

Key Topics Covered:

1. Introduction

- Part I. Molecular and Cellular Principles:

2. Biomolecular principles

3. Biomolecular principles: nucleic acids

4. Biomolecular principles: proteins

5. Cellular principles

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Research and Markets: Biomedical Engineering. Bridging Medicine and Technology

Tough Medicine

Roy Halladays struggles have been a big part of the Phillies surprisingly slow start. (AP)

A rough season for the Phillies just got a lot rougher, as Roy Halladay is headed to the disabled list for 6-8 weeks because of a strained right shoulder.

Halladays injury is a surprise, given that the two-time Cy Young winner has long been among the most durable pitchers in baseball. Even after he exited his start on Sunday after just two innings because of shoulder soreness, his 72 1/3 innings this year was tops in the National League, and since the beginning of 2006, nobody has thrown more innings than his 1,487 (CC Sabathia at 1,463 and Dan Haren at 1,429 are the only pitchers within 100 innings). He hasnt been on the disabled list for an arm-related injury since 2004, when a shoulder strain cost him two months (though he missed the second half of 2005 due to a broken leg), and has averaged 32 starts per year from 2006-11.

Even so, its been clear that the 35-year-old Halladay has not been his normal excellent self. Through 11 starts, his 3.98 ERA is about three-quarters of a run higher than his career mark and his highest since 2004 following back-to-back starts in which he allowed a total of nine runs in eight innings. His home run rate has nearly doubled relative to last season, from 0.39 per nine to a still-impressive 0.75, and while his strikeout and walk rates (7.0 and 1.7 per nine, respectively) are just whiskers away from his career marks, they would represent his worst since 2007.

Underlying those numbers, Halladays average fastball velocity has deteriorated from 93.7 MPH in 2009 to 91.6 this season, according to the park-adjusted data at BrooksBaseball.net, and hes throwing more curveballs and fewer fastballs than before. Pitching coach Rich Dubee has noted that he hasnt been getting his typical movement on pitches, that he hasnt been executing those pitches consistently and that his cranky shoulder has been a lingering issue, a constellation of symptoms that are likely tied together. The PITCHf/x data suggests his release point has been slightly lower, though Will Carroll noted that the general trend is for aging pitchers to remain more upright.

Halladays absence leaves the Phillies with only two ace-caliber pitchers in Cole Hamels and Cliff Lee, but even so, the team is already facing an uphill battle. The five-time defending NL East champions enter Tuesday tied for fourth place in the division and, at 26-24, just two games above .500. With both Ryan Howard and Chase Utley yet to play a game this year due to injuries, their offense has been held together by duct tape, Carlos Ruiz (.366/.419/.592) and Juan Pierre (.314/.354/.350); the teams 4.16 runs per game ranks seventh in the NL, 0.02 above the league average. The bullpen has the leagues second-worst ERA (4.65), and thats not even including their league-worst rate of allowing inherited runners to score (43 percent). Its their rotation, which ranks third in ERA (3.35) and first in quality start rate (70 percent) and innings per start (6.6) softening the blow from that bullpen just a bit thats kept them afloat.

Even so, the rotations depth is already being tested. Lee lost three weeks due to an oblique strain earlier this season, and Vance Worley went on the disabled list two weeks ago due to inflammation caused by bone chips in his elbow, pressing swingman Kyle Kendrick into starting duty yet again. Worley is playing long-tossand hoping to throw a bullpen session this week, but it may be three weeks before hes back in the fold. If Halladay goes on the disabled list, a retread such as David Bush, Scott Elarton, or Pat Misch is the likely patch. All are currently in Triple-A Lehigh Valleys rotation, and all are the definition of replacement level, having more or less pitched their way out of the majors in recent years.

Bush (4.70 career ERA) threw just 37 1/3 innings of 5.79 ERA ball for the Rangers in 2011, Misch (4.80 career ERA) lasted just seven innings with last years Mets and Elarton (5.29 career ERA) last appeared on the big league scene with Cleveland in 2008 and didnt pitch anywhere last year. Twenty-five-year-old righty Tyler Cloyd is the minor league systems hottest pitcher (2.01 ERA and 7.0 strikeouts per nine in 10 starts split between Double-A and Triple-A), but Baseball America didnt even consider him among the teams top 30 prospects at the outset of the season, and thats in an organization that itself ranked 27th out of 30.

Beyond those less-than-stellar options, one name from outside the organization stood out: Roy Oswalt, who pitched for the Phils in late 2010 and 2011 but decided to wait until the season was underway before choosing a destination. On Tuesday afternoon, just as news of Halladays DL trip was being announced, came reports thatOswalt would be signing with the Texas Rangers. In a matter of minutes the news for Philadelphia went from bad to worse.

The Phillies now must hope that their season doesnt do the same, but without Halladay, they will be hard-pressed to reach the playoffs for the sixth straight year.

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Tough Medicine

Is Geriatric Medicine Terminally Ill?

Adam G. Golden, MD, MBA; Michael A. Silverman, MD, MPH, CMD; and Michael J. Mintzer, MD From the University of Central Florida College of Medicine and Orlando Veterans Affairs Medical Center, Orlando; West Palm Beach Veterans Affairs Medical Center, West Palm Beach; and University of Miami Miller School of Medicine and the Miami Geriatric Research Education and Clinical Center, Bruce W. Carter Veterans Affairs Medical Center, Miami, Florida.

Geriatric medicine was established as a discipline to care for the complex needs of elderly patients (1). After much pioneering work, the American Board of Internal Medicine and American Board of Family Medicine granted geriatric medicine a Certificate of Added Qualifications in 1988. Board eligibility required completion of an accredited 2-year fellowship or qualification under the practice pathway based on practice experience.

Even with this recognition, geriatric medicine in the United States has struggled to clearly identify its clinical niche and to attract interest among physicians (2). After closure of the practice pathway in 1994, the number of physicians seeking certification decreased 4-fold (3). In an attempt to increase the number of geriatric fellows, the duration of fellowship was shortened from 2 years to 1 in 1998. In 2006, the American Board of Internal Medicine elevated geriatric medicine to a subspecialty under internal medicine, allowing physicians to recertify in geriatrics without recertifying in internal medicine. Additional incentives to create fellowship positions included exemption from limits to the number of graduate medical education positions funded by Medicare. Yet, despite a continual albeit small increase in available fellowship positions, 44% remain unfilled (4). Geriatrics remains an unpopular career choice among graduates of U.S. medical schools (4). Furthermore, only about half of all internal medicine geriatricians recertify in their subspecialty board, compared with 81% among other subspecialties (3).

With the graying of America, geriatric medicine should, in theory, be a thriving subspecialty. Instead, 2 questions arise: Why the lack of interest in geriatric medicine? Can the subspecialty survive?

Despite surveys that report high job satisfaction, geriatric medicine remains an unpopular career choice for physicians because of perceived low prestige, futility of care, and low remuneration. Indeed, geriatricians' salaries are lower than those of either general internal medicine

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Is Geriatric Medicine Terminally Ill?

Implementing Lifesaving Practices in Medicine

FARMINGTON, Conn.--(BUSINESS WIRE)--

Widely published, Atul Gawande, MD, has devoted research time to studies on reducing error, improving safety, and increasing efficiency in surgery. BroadcastMed is proud to highlight Brigham and Womens Hospitals MD Video Education Center, which is hosting The Checklist Manifesto: Implementing Lifesaving Practices in Medicine. In this Grand Rounds presentation Dr. Gawande, a general and endocrine surgeon at Brigham and Womens Hospital, discusses lifesaving practices in medicine - the topic of his New York Times bestselling book The Checklist Manifesto: How to Get Things Right. He speaks about developing a checklist, areas that lend themselves to a checklist, and ways to implement a checklist.

Physicians can watch and learn about The Checklist Manifesto: Implementing Lifesaving Practices in Medicine and view other peer-focused videos by visiting Brigham and Womens Hospitals MD Video Education Center.

About BroadcastMed, Inc.

BroadcastMed is an online medical broadcasting company. We help the Worlds leading hospitals and medical device companies create and deliver trusted educational content to physicians. Our clients rely on us to deliver measurable results by expanding their reach through the BroadcastMed syndication network which includes ORLive.com, ranked among the top three online destinations for physicians.

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Implementing Lifesaving Practices in Medicine

Research and Markets: Understanding Medical Research: The Studies That Shaped Medicine

DUBLIN--(BUSINESS WIRE)--

Dublin - Research and Markets (http://www.researchandmarkets.com/research/nkt6w6/understanding_medi) has announced the addition of John Wiley and Sons Ltd's new book "Understanding Medical Research: The Studies That Shaped Medicine" to their offering.

Medical students and junior and senior doctors are frequently called upon to give research presentations, write reports, and answer exam questions on specific areas of medical research.

Understanding Medical Research: The Studies That Shaped Medicine is an exciting new title that offers a unique and valuable approach to understanding historically influential studies in important areas of medicine.

Featuring chapters from Sir Liam Donaldson and Sir David Weatherall, amongst others, world leading researchers identify ten primary research papers that have shaped the direction of research in their given topic, examining why they were carried out, key findings, and how they changed the field.

Each chapter also contains short sections on Key Questions Remaining' which outline outstanding areas where further research is needed, and a link to Key Laboratories/Clinics' which point the reader to major research groups of international standing.

Covering the seminal research in core areas of medicine, Understanding Medical Research provides an authoritative framework on each topic for medical students and healthcare professionals.

Key Topics Covered:

1 Population Health

2 Patient Safety

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Research and Markets: Understanding Medical Research: The Studies That Shaped Medicine

Research and Markets: Pediatric Cardiovascular Medicine, 2nd Edition

DUBLIN--(BUSINESS WIRE)--

Dublin - Research and Markets (http://www.researchandmarkets.com/research/scw665/pediatric_cardiova) has announced the addition of John Wiley and Sons Ltd's new book "Pediatric Cardiovascular Medicine, 2nd Edition" to their offering.

The first edition of this text, edited by two of the world's most respected pediatric cardiologists, set the standard for a single-volume, clinically focused textbook on this subject. This new edition, revised and updated by contributors representing today's global thought leaders, offers increased coverage of the most important current topics, such as pediatric electrophysiology, congenital heart disease, cardiovascular genetics/genomics, and the identification and management of risk factors in children, while maintaining the clinical focus. Published with a companion website that features additional images for download, self-assessment questions designed to aid readers who are preparing for examinations, and other features, Pediatric Cardiovascular Medicine, Second Edition, is the perfect reference for residents, fellows, pediatricians, as well as specialists in pediatric cardiology.

Key Topics Covered:

List of Contributors

Preface

1 Normal and Abnormal Cardiac Development,

2 Genetics of Cardiovascular Disease in the Young,

3 Developmental Physiology of the Circulation,

4 Basic Anatomy and Physiology of the Heart, and Coronary and Peripheral Circulations,

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Research and Markets: Pediatric Cardiovascular Medicine, 2nd Edition

EHE International Certifies Drexel University College of Medicine as Preventive Care Center

NEW YORK, May 29, 2012 /PRNewswire/ --EHE International, a nationally recognized leader in preventive medicine and annual physical exams, today announced that the Drexel University College of Medicine in Philadelphia, Pa., has been named an EHE-certified preventive care center. Through Drexel's multi-specialty practice, thousands of EHE members in the Philadelphia region now have greater access to EHE's programs, which help them maintain their health through a focus on preventive medicine.

"EHE is proud to add Drexel University to its growing private provider network. This is a natural fit for both organizations based on our shared understanding that prevention and early detection are vital to good health," said Deborah McKeever, president of EHE International. "EHE members will undoubtedly benefit from the expertise and experience of the Drexel network of 250 doctors practicing in more than 40 specialized areas of medicine."

As an EHE-certified center, Drexel University College of Medicine meets EHE's strict preventive care clinical protocols. The faculty-driven practice can facilitate the diagnostic testing at the core of EHE's preventive approach to health, and the multi-specialty Drexel Medicine network can provide ongoing care for EHE members should other specialized care or consultation be warranted. Drexel University is the fourth EHE-certified care center in the Philadelphia area. EHE has certified care centers in 42 states.

"Drexel Medicine is excited for the opportunity to expand our current program and serve even more patients through the EHE certification," said Dr. Richard G. Paluzzi, medical director for the Drexel Medicine Executive Health and Wellness Program. "Drexel and EHE's commitment to the idea that good medicine begins with promoting healthy living will give our patients the quality of preventive medical care that they expect and deserve."

"EHE's continued expansion in the Philadelphia area and across the United States is a sign that more and more employers are realizing the benefits of clinically based, standardized protocols in preventive health and annual exams, as opposed to the traditional reactive insurance model," added McKeever. "It is well-recognized that a focus on prevention helps control future healthcare costs, improves productivity and allows employees to proactively manage their own health. EHE has a century of experience in caring for employers greatest asset, its employees."

About EHE InternationalSince 1913, EHE International has been the recognized leader in preventive medicine. Its clinical protocols are specifically designed for early detection of preventable disease and associated risk factors, supported by robust personal coaching and health management tools and resources. EHE International is the oldest and largest preventive medicine specialist and its clinically based educational and social engagement platforms are the preferred choice among America's leading employers. For more information, visitwww.eheintl.com.

About Drexel University College of MedicineDrexel University College of Medicine has established some of the most innovative and rigorous academic programs available today, incorporating the University's expertise in engineering and technology into traditional medical training. The College of Medicine is home to one of the nation's leading centers for spinal cord research; one of the foremost centers for malaria study; and a highly regarded HIV/AIDS program with extensive NIH-funded research in prevention and therapeutic interventions. Drexel University College of Medicine has been designated a Vanguard National Center of Excellence in Women's Health by the U.S. Department of Health & Human Services, and is highly respected in numerous other specialties including cardiology and pain management.

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EHE International Certifies Drexel University College of Medicine as Preventive Care Center

Swedish researchers discovery promises unique medicine for treatment of chronic and diabetic wounds

28.05.2012 - (idw) Schwedischer Forschungsrat - The Swedish Research Council

A unique new medicine that can start and hasten healing of diabetic and other chronic sores is being developed at Ume University in Sweden. After several years of successful experimental research, it is now ready for clinical testing. Behind this new medicine is a group of researchers at the Department of Medical Chemistry and Biophysics who have made the unique finding that the protein plasminogen is a regulator that initiates and hastens wound healing by triggering the inflammatory reaction. Their discovery is now being published in the highly ranked journal Blood.

Today we have the knowledge needed to develop a medicine, says Professor Tor Ny, one of the authors of the article. The bulk of the preclinical research has been completed, and we have been in contact with the Medical Products Agency to discuss a program for clinical testing.

Plasminogen is a well-known plasma protein that is produced in the liver and found in all bodily fluids. The Ume researchers have re-evaluated its role and managed to show that the concentration of plasminogen increases dramatically in and around wounds, which is an important signal to start the inflammatory reaction required for healing. In diabetic sores the level of plasminogen does not rise in the same way, and this seems to be the reason why these sores do not heal. In mice and rats the researchers were able to show that the healing process starts immediately when plasminogen is injected into the sore, which then heals fully.

The need for a biological pharmaceutical for treating intractable wounds is pressing indeed. Diabetic sores that heal poorly or not at all are the most severe type of chronic sores, affecting millions of people annually. Many of the roughly 350 million diabetes patients in the world develop foot ulcers, and in 10-15 million cases this ultimately leads to amputation. Todays treatment of diabetic ulcers consists primarily of traditional wound care, with compresses and bandages; there is no effective medication.

The Ume researchers are initially concentrating on diabetic wounds, but the medicine has great potential for working on other types of stubborn sores. This includes damaged eardrums and periodontitis. The new pharmaceutical has moreover been shown to be helpful in combatting antibiotic-resistant bacteria (MRSA).

Reference Yue Shen, Yongzhi Guo, Peter Mikus, Rima Sulniute, Malgorzata Wilczynska, Tor Ny, Jinan Li: Plasminogen is a key proinflammatory regulator that accelerates the healing of acute and diabetic wounds Blood. 2012 May 4. [Epub ahead of print]

For more information, please contact Professor Tor Ny: mobile: +46 (0)73-620 50 65; e-mail tor.ny@medchem.umu.se jQuery(document).ready(function($) { $("fb_share").attr("share_url") = encodeURIComponent(window.location); });

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Swedish researchers discovery promises unique medicine for treatment of chronic and diabetic wounds

Discovery promises unique medicine for treatment of chronic and diabetic wounds

ScienceDaily (May 28, 2012) A unique new medicine that can start and accelerate healing of diabetic and other chronic wounds is being developed at Ume University in Sweden. After several years of successful experimental research, it is now ready for clinical testing.

Behind this new medicine is a group of researchers at the Department of Medical Chemistry and Biophysics who have made the unique finding that the protein plasminogen is a key-regulator that initiates and accelerates wound healing by triggering the inflammatory reaction. Their discovery is now being published in the journal Blood.

Today we have the knowledge needed to develop a medicine, says Professor Tor Ny, one of the authors of the article. The bulk of the preclinical research has been completed, and we have had meetings with the Medical Product Agency to discuss a program for clinical testing.

Plasminogen is a well-known plasma protein that is produced in the liver and found in all bodily fluids. The Ume researchers have now re-assessed its role and managed to show that the concentration of plasminogen increases dramatically in and around wounds, which is an important signal to start the inflammatory reaction required for healing. In diabetic wounds the level of plasminogen does not increase in the same way, and this seems to be the reason why these wounds do not heal. In diabetic mice and rats the researchers were able to show that the healing process starts immediately when plasminogen is injected around the wound, which then heals fully.

A cell line for producing plasminogen on a larger scale has also been developed, and the goal is to start clinical testing as soon as funding can be arranged. The researchers have high hopes, as plasminogen is an endogenous protein that can be assumed not to produce side effects.

The need for a biologics for treating chronic wounds is urgent. Diabetic wounds that do not heal are the most severe type of chronic wounds, affecting millions of people annually. Many of the roughly 350 million diabetes patients in the world develop foot ulcers, and in 10-15 million cases this ultimately leads to amputation. Todays treatment of diabetic wounds consists primarily of traditional wound care, with compresses and bandages; there is no effective medication.

The Ume researchers are initially concentrating on diabetic wounds, but plasminogen also has great potential for working on other types of wounds. This includes tympanic membrane perforations and periodontitis. Being a pro-inflammatory activator, plasminogen has moreover been shown to be effective in combating antibiotic-resistant bacteria (MRSA).

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Discovery promises unique medicine for treatment of chronic and diabetic wounds

Medicine honoured with Jubilee medal

By Duane Hicks, Staff writer

Being presented with a Queen Elizabeth II Diamond Jubilee Medal was the last thing Rainy River First Nations elder Dorothy Medicine expected while attending the 42nd-annual Manitou Fish Fry on Friday. I was very surprised, said Medicine after being given the medal by local MP John Rafferty at the Rainy River First Nations pow-wow grounds.

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Medicine honoured with Jubilee medal

The Mayor's Red Dirt Ball is boosting tourism in Medicine Park

LAWTON, OK._Medicine Park is celebrating itself this weekend with Red Dirt music, unique vendors and good food for the fourth year in a row.

Each year the Mayor's Red Dirt Ball attracts locals and folks from around the country to the small art community.

For them it is a time to celebrate the town and its growing nation-wide recognition.

The celebration started on Friday, but it has not slowed down.

Medicine Park has a humble population of under 400 people.

They may be small in number, but they are proud residents, as they should be.

A few years back, Medicine Park was named the "9th Coolest Small Town in America.

And the word must be spreading fast because the town was filled today with art, food and music enthusiasts.

Three days, 15 red dirt bands, 20 vendors means one great weekend in our areas hideaway in the mountains.

"Laid back people, a lot of great art, and we try to bring in some great music to go along with it," said Mayor Dwight Cope.

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The Mayor's Red Dirt Ball is boosting tourism in Medicine Park

American College of Traditional Chinese Medicine San Francisco Opens Herbal Clinic

The American College of Traditional Chinese Medicine has now added an in-house herbal clinic to its 913-room facility in San Francisco. Patients can receive premium quality organic herbal remedies selected by trained professionals.San Francisco, CA (PRWEB) May 26, 2012 The American College of Traditional Chinese Medicine San Francisco (ACTCM) recently opened its herbal clinic in the Potrero Hill ...

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American College of Traditional Chinese Medicine San Francisco Opens Herbal Clinic

Automated Biometric Kiosk secures prescription medicine.

The Medbox Storage and Access System (SAS) was developed in response to the growing need for better and more secure storage of medicines and sensitive supplies in doctor's offices, clinics, hospitals, and pharmacies.

It is estimated that over $100 million worth of prescription medicine is stolen each year. Just last week, eleven people were charged with the theft of over $75 million worth of prescription medicines from an office in Connecticut.

The stolen medications, including Zyprexa (olanzapine), Cymbalta (duloxetine), Prozac (fluoxetine), and Gemzar (gemcitabine for injection), were recovered in a Florida warehouse. Authorities say the perpetrators would have escaped undetected if it weren't for a fingerprint left behind at the scene of the crime.

"For several years now, theft in the pharmaceutical sector has been on the rise, exacting a terrible cost on the industry and danger to the public," said US Attorney David Fein, in an article appearing in The New York Times.

This particular theft is notable because the drugs stolen by the thieves are not the usual targets, which are often addictive painkillers like Oxycodone or Fetanyl. On the contrary, the drugs at the center of this theft consist of costly specialty items that treat chronic conditions such as cancer, arthritis, Crohn's disease, and autoimmune disorders, and pose a real danger, especially if they aren't properly stored, refrigerated, or handled before they are used by patients.

The Medbox System is the world's first secure method to safely store medicine, control access based on customized preferences (certain employees can obtain access to certain medications), and provide an unalterable permanent record of each time a medicine was accessed. This allows pharmacists and doctors to increase security without any hindrances, and lower risk of theft and potential liability.

About Medbox, Inc:

Medbox is a leader in the development, sales and service of automated, biometrically controlled dispensing and storage systems for medicine and merchandise. Medbox has offices throughout the world, including New York, Tokyo and Toronto, and has their corporate headquarters in Los Angeles.

Medbox provides their patented systems, software and consulting services to pharmacies, urgent care centers, clinics, hospitals, and medical groups worldwide.

Medbox, Inc. is a publicly traded company, and is listed on the OTC Board, ticker symbol MDBX.

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Automated Biometric Kiosk secures prescription medicine.

Dr. Shui-Yin Lo Accepts Appointment to the Scientist Advisory Board of the Academy of Comprehensive Integrative Medicine

PANAMA CITY--(Marketwire -05/23/12)- The Academy of Comprehensive Integrative Medicine ("ACIM") is pleased to announce the appointment of Shui-Yin Lo, PhD, and Chairman of the Board for Double Helix Water, to its Scientific Advisory Board. Dr. Lo joins a number of internationally acclaimed scientists and medical doctors on the Scientific Advisory Board.

"We are pleased that such an outstanding member of the scientific community has agreed to join us. One of Dr. Lo's first projects is the formation of the School of Quantum Medicine for the Academy. He brings a wealth of knowledge, experience, and dedication to the Academy. Until the addition of Dr. Lo, the Academy has been comprised solely of The School of Integrative Medicine," said Dr. Lee Cowden, Chairman of the Scientific Advisory Board.

"This is a significant step toward the ultimate goal of creating a number of additional schools under the umbrella of the Academy. We hope to add a School of Integrative Nursing and a School of Biological Dentistry in the near future," said Mr. Bill Gonseaux, the CEO of the Academy.

Dr. Lo serves as a Professor of Physics and a Professor of Research in Chinese Medicine at the American University of Complementary Medicine. He is also a Director at the Quantum Health Research Center, Pasadena, CA. He is a former visiting faculty member in the Department of Chemistry, California Institute of Technology (CalTech) and has had visiting faculty appointments with more than ten international centers of excellence, such as Oxford University, Free Berlin University, Stanford, McGill University, Academia Sinica of Beijing, and others. A Ph.D. graduate of the University of Chicago, Dr. Lo holds more than thirty patents and is a prolific writer, having authored four books and more than one hundred peer reviewed professional articles.

ACIM

Headquartered in the Republic of Panama, the Academy of Comprehensive Integrative Medicine ("ACIM") is an internet-based learning community dedicated to providing the best in integrative medicine education while supplying its members with unique opportunities in research and think tanks. ACIM believes that a few standing together, with hope and determination, seeking the truth above all else, can change the dynamic of how health and wellness is defined. In this definition is embodied the right of each person to determine their own course of health and wellness. For more information about ACIM please contact Lisa Wade in the USA (972.410.8120 or lisa@acimconnect.com) and/or visit http://www.acimconnect.com.

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Dr. Shui-Yin Lo Accepts Appointment to the Scientist Advisory Board of the Academy of Comprehensive Integrative Medicine

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