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Neuroscience and Academic Medicine | Ayden Jacob and Internet Medicine – Video

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Neuroscience and Academic Medicine | Ayden Jacob and Internet Medicine
Neuroscience Writing: What are the pitfalls? What is the future of neuroscience writing? Join Ayden Jacob and John Hewitt as we discus John #39;s work as a unique neuroscience writer.

By: NEUROSCIENCE

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Neuroscience and Academic Medicine | Ayden Jacob and Internet Medicine - Video

The Lancet and The Lancet Respiratory Medicine: Controlling, diagnosing, and preventing asthma

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PUBLIC RELEASE DATE:

1-May-2014

Contact: John R Balmes jbalmes@medsfgh.ucsf.edu 510-220-0502 The Lancet

On Friday 2 May, 2014, The Lancet and The Lancet Respiratory Medicine will release three new review articles and an Editorial on asthma, ahead of World Asthma Day on May 6 and the American Thoracic Society's international conference (ATS 2014) in San Diego (May 16-21).

The Lancet: Outdoor air pollution and asthma

Traffic and power generation are the main sources of urban air pollution. The idea that outdoor air pollution can cause exacerbations of pre-existing asthma is supported by an evidence base that has been accumulating for several decades, with several studies suggesting a contribution to new-onset asthma as well. In this review, Professors Michael Guarnieri and John R Balmes, of the University of California, San Francisco, USA, discuss the effects of particulate matter (PM), gaseous pollutants (ozone, nitrogen dioxide, and sulphur dioxide), and mixed traffic-related air pollution on asthma. Reviewing evidence from the past five years, they suggest that air pollutants probably cause oxidative injury to the airways, leading to inflammation, remodelling, and increased risk of sensitisation. Although several pollutants have been linked to new-onset asthma, the strength of the evidence is variable. The authors also discuss clinical implications, policy issues, and research gaps relevant to air pollution and asthma.

The Lancet Respiratory Medicine: Asthma genetics and personalised medicine

In this review, Professor Stephen Holgate and colleagues at the Faculty of Medicine, University of Southampton, UK, and collaborators in the US, discuss genetic approaches to asthma, which have identified novel genetic targets in the pathogenesis of the disease, although so far these targets account for only a small proportion of the heritability of asthma. Recognition of the importance of disease heterogeneity, the need for improved disease phenotyping, and the fact that genes involved in the inception of asthma are likely to be different from those involved in severity, widens the scope of asthma genetics. The identification of genes implicated in several causal pathways suggests that genetic scores which capture multiple gene effects could be used to capture the individual influence of genes on the expression and treatment opportunities for this disease in individuals. Geneenvironment interaction adds another layer of complexity, which is being successfully explored by epigenetic approaches that assess how the human genome is accessed. Pharmacogenetics is one example of how geneenvironment interactions are already being taken into account in the identification of drug responders and non-responders, and patients most susceptible to adverse effects. Such applications represent one component of personalised medicine, an approach that places the individual at the centre of health care.

The Lancet: Diagnosis, management, and prognosis of preschool wheeze

Preschool children (ie, those aged 5 years or younger) with wheeze consume a disproportionately high amount of health-care resources compared with older children and adults with wheeze or asthma, representing a diagnostic challenge, according to this Review by Professor Francine Ducharme, of CHU Sainte-Justine, Cte Sainte-Catherine, Canada, and colleagues. Several risk factors related to genetic, prenatal, and postnatal environment are associated with preschool wheezing, and findings from several studies have shown that preschool children with wheeze have deficits in lung function at six years of age that persisted until early and middle adulthood, suggesting increased susceptibility in the first years of life that might lead to persistent sequelae. Interventions to modify the short-term and long-term outcomes of preschool wheeze should be a research priority, say the authors.

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The Lancet and The Lancet Respiratory Medicine: Controlling, diagnosing, and preventing asthma

Philip W. Brickner MD, Department of Community Medicine St. Vincent’s Hospital, New York – Video

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Philip W. Brickner MD, Department of Community Medicine St. Vincent #39;s Hospital, New York
Philip W. Brickner MD - Last staff meeting as Chairman of The Department of Community Medicine St. Vincent #39;s hospital, New York.

By: Nell Eakin

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Philip W. Brickner MD, Department of Community Medicine St. Vincent's Hospital, New York - Video

Daughter – Medicine [subtitulado espaol] + Lyrics (Official Video) – Video

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Daughter - Medicine [subtitulado espaol] + Lyrics (Official Video)
Daughter - Medicine Cinematics #39; #39;The Division Of Gravity #39; #39; By #39; #39;Rob Chiu #39; #39; http://icanseeyoustayinghere.tumblr.com/ http://instagram.com/belml24 https://twitter.com/MendozaBell24 https://www.face...

By: Bel Mendoza

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Daughter - Medicine [subtitulado espaol] + Lyrics (Official Video) - Video

Regenerative medicine approach improves muscle strength, function in leg injuries

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PUBLIC RELEASE DATE:

30-Apr-2014

Contact: Anita Srikameswaran SrikamAV@upmc.edu 412-578-9193 University of Pittsburgh Schools of the Health Sciences

PITTSBURGH, April 30, 2014 Damaged leg muscles grew stronger and showed signs of regeneration in three out of five men whose old injuries were surgically implanted with extracellular matrix (ECM) derived from pig bladder, according to a new study conducted by researchers at the University of Pittsburgh School of Medicine and the McGowan Institute for Regenerative Medicine. Early findings from a human trial of the process and from animal studies were published today in Science Translational Medicine.

When a large volume of muscle is lost, typically due to trauma, the body cannot sufficiently respond to replace it, explained senior investigator Stephen F. Badylak, D.V.M., Ph.D., M.D., professor of surgery at Pitt and deputy director of the McGowan Institute, a joint effort of Pitt and UPMC. Instead, scar tissue can form that significantly impairs strength and function.

Pig bladder ECM has been used for many years as the basis for medical products for hernia repair and treatment of skin ulcers. It is the biologic scaffold that remains left behind after cells have been removed. Previous research conducted by Dr. Badylak's team suggested that ECM also could be used to regenerate lost muscle by placing the material in the injury site where it signals the body to recruit stem and other progenitor cells to rebuild healthy tissue.

"This new study is the first to show replacement of new functional muscle tissue in humans, and we're very excited by its potential," Dr. Badylak said. "These are patients who can't walk anymore, can't get out of a car, can't get up and down from a chair, can't take steps without falling. Now we might have a way of helping them get better."

For the Muscle Tendon Tissue Unit Repair and Reinforcement Reconstructive Surgery Research Study, which is sponsored by the U.S. Department of Defense and is continuing to enroll new participants, five men who had at least six months earlier lost at least 25 percent of leg muscle volume and function compared to the uninjured limb underwent a customized regimen of physical therapy for 12 to 26 weeks until their function and strength plateaued for a minimum of two weeks.

Then, study lead surgeon J. Peter Rubin, M.D., UPMC Professor and chair of plastic surgery, Pitt School of Medicine, surgically implanted a "quilt" of compressed ECM sheets designed to fill into their injury sites. Within 48 hours of the operation, the participants resumed physical therapy for up to 26 additional weeks.

The researchers found that three of the participants, two of whom had thigh injuries and one a calf injury, were stronger by 20 percent or more six months after the surgery. One thigh-injured patient improved on the "single hop test" by 1,820 percent, and the other had a 352 percent improvement in a chair lift test and a 417 percent improvement in the single-leg squat test. Biopsies and scans all indicated that muscle growth had occurred. Two other participants with calf injuries did not have such dramatic results, but both improved on at least one functional measure and said they felt better.

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Regenerative medicine approach improves muscle strength, function in leg injuries


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