Last period of flu season saw very low levels – Medicine Hat News

By GILLIAN SLADE on September 5, 2020.

gslade@medicinehatnews.com

In the final weeks of the official 2019/2020 influenza season there were exceptionally low levels.

According to the FluWatch report, issued by the Public Health Agency of Canada, the percentage of positive tests remained at the lowest level recorded for the past nine seasons.

COVID-19 contributed to this, according to the report, due to changes in healthcare-seeking behaviour, the impact of public health measures such as social distancing and the testing capacity for influenza testing.

The peak of the influenza season appears to have taken place in mid-March nationally, which is about nine weeks earlier compared to the past five seasons.

The season ran from Aug. 25, 2019 to Aug. 22, 2020. Based on data collected in November and December, 2019 the effectiveness of influenza vaccine was measured.

It was estimated to be 58 per cent effective for any influenza, 44 per cent effective for influenza A (H1N1), 62 per cent effective for influenza A (H3N2) and 69 per cent effective for influenza B. It was particularly effective for children up to age 19, there was a good level of protection among working age adults 20 to 64 years. Among adults over 65 years, although imprecise due to small numbers, was lower at 18 per cent, the report states. Additional numbers are still to come.

The last influenza update for Alberta was issued on May 7. There had been 8,470 laboratory confirmed cases of flu, 1534 people had been hospitalized, and 39 deaths.

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New England Journal of Medicine publishes study results evaluating Ionis antisense therapy in treatment of patients with hereditary angioedema -…

CARLSBAD, Calif., Sept. 2, 2020 /PRNewswire/ --Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) announced the publication today of the results from a compassionate-use study evaluating IONIS-PKKRx and IONIS-PKK-LRx in patients living with severe bradykinin-mediated angioedema in The New England Journal of Medicine (NEJM). IONIS-PKKRx and IONIS-PKK-LRx are investigational antisense medicines designed to reduce the production of prekallikrein, or PKK, which plays a key role in the activation of inflammatory mediators associated with acute attacks of hereditary angioedema (HAE). In the study, researchers found that the drugs reduced plasma prekallikrein activity levels and showed evidence of clinical efficacy in reducing the number of breakthrough attacks per month in patients over the course of the treatment, including complete resolution in a patient with Type 1 HAE. To view the published study, please visit NEJM.org.

Hereditary angioedema is a rare autosomal dominant disease that results in recurrent, painful attacks of swelling affecting the arms, legs, face, intestinal track and airway. Without preventive treatment, attacks can be frequent and severe and, in some patients, life-threatening. The majority of HAE cases are caused by genetic mutations that lead to either a deficiency (Type 1 HAE) or dysfunction (Type 2 HAE) of C1 esterase inhibitor (C1-INH), which regulates multiple pathways, including the kallikrein-kinin and contact system. In the third, especially rare form of the disorder (Type 3 HAE or HAE-nC1-INH), which occurs predominantly in women, and in which the cause is often unknown, patients have a higher frequency of facial, pharyngeal and tongue swelling.

"The results of this study are encouraging and support continued development of IONIS-PKK-LRx as a potential treatment in patients with severe hereditary angioedema for whom current therapies offer limited therapeutic benefit. The study also highlights the progress we continue to make advancing investigational medicines that are wholly owned by Ionis," said Richard S. Geary, Ph.D., Ionis' executive vice president of Development and a co-author on the paper published in NEJM.

In the study, two patients Patient 1 with Type 1 HAE and Patient 2 with Type 3 HAE were first treated with IONIS-PKKRx for a period of 12 to 16 weeks, after which they received IONIS-PKK-LRx at a dose of 80 mg every three to four weeks for seven to eight months at the time of data analysis. During treatment with the ligand-conjugated IONIS-PKK-LRx and the unconjugated parent drug, IONIS-PKKRx, there was a clinically meaningful reduction in HAE attack rates in both patients. Plasma prekallikrein activity levels decreased substantially following treatment.

Physicians have long prescribed prophylactic treatment approaches, including C1-INH replacement therapies and more recently inhibitors of plasma kallikrein, to prevent and reduce the severity of HAE attacks. IONIS-PKK-LRx is an investigational antisense medicine that is being developed because it has the potential to provide significant efficacy with the convenience of once per month low volume subcutaneous injections.

Ionis' Forward-looking Statement

This press release includes forward-looking statements regarding Ionis' business and the therapeutic potential of IONIS-PKK-LRx, IONIS-PKKRx and Ionis' technologies and products in development. Any statement describing Ionis' goals, expectations, financial or other projections, intentions or beliefs is a forward-looking statement and should be considered an at-risk statement. Such statements are subject to certain risks and uncertainties, particularly those inherent in the process of discovering, developing and commercializing drugs that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such drugs. Ionis' forward-looking statements also involve assumptions that, if they never materialize or prove correct, could cause its results to differ materially from those expressed or implied by such forward-looking statements. Although Ionis' forward-looking statements reflect the good faith judgment of its management, these statements are based only on facts and factors currently known by Ionis. As a result, you are cautioned not to rely on these forward-looking statements. These and other risks concerning Ionis' programs are described in additional detail in Ionis' annual report on Form 10-K for the year ended December 31, 2019, and the most recent Form 10-Q quarterly filing, which are on file with the SEC. Copies of these and other documents are available from the Company.

In this press release, unless the context requires otherwise, "Ionis," "Company," "we," "our," and "us" refers to Ionis Pharmaceuticals and its subsidiaries.

Ionis Pharmaceuticals is a trademark of Ionis Pharmaceuticals, Inc.

About Ionis Pharmaceuticals

As the leader in RNA-targeted drug discovery and development, Ionis has created an efficient, broadly applicable, drug discovery platform called antisense technology that can treat diseases where no other therapeutic approaches have proven effective. Our drug discovery platform has served as a springboard for actionable promise and realized hope for patients with unmet needs. We created the first and only approved treatment for children and adults with spinal muscular atrophy as well as the world's first RNA-targeted therapeutic approved for the treatment of polyneuropathy in adults with hereditary transthyretin amyloidosis. Our sights are set on all the patients we have yet to reach with a pipeline of more than 40 novel medicines designed to potentially treat a broad range of disease, including neurological, cardio-renal, metabolic, infectious, and pulmonary diseases.

To learn more about Ionis visit http://www.ionispharma.com or follow us on twitter @ionispharma.

SOURCE Ionis Pharmaceuticals, Inc.

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U.S. Senate, including Tillis and Burr, must act to save military medicine – The Fayetteville Observer

Tom Jurkowsky| The Fayetteville Observer

For the past several years, the Department of Defense (DoD) has been relentless in its attempt to cut 18,000 medical positions. The cuts represent a 20 percent reduction and would affect all the military services.

At Fort Bragg, both the Joel and Robinson outpatient facilities would be closed or downsized. Beneficiaries would be forced to obtain care from civilian providers, potentially creating health care shortages for both military beneficiaries and civilians seeking care in surrounding communities.

Congress fortunately has not yet authorized DoD to make the cuts. Last year, Congress directed a pause to ensure DoD conducted an assessment on the impacts such cuts may have on beneficiaries. This included not just the cost effectiveness of the cuts but whether civilian providers were even able to accommodate the military beneficiaries.

This year the House Armed Services Committee has once again made the right decision, telling DoD to conduct a more accurate and complete evaluation of its proposal by including provisions in its version of the National Defense Authorization Act (NDAA) that increase transparency, DoD reporting requirements and congressional oversight of the medical facility restructuring and personnel reductions.

The Armed Services Committee, like the General Accountability Office (GAO), told DoD that it needed to do a more accurate and complete evaluation of civilian care availability for its beneficiaries active duty members, their families and retired military personnel who qualify for medical care.

In its study of the issue, the GAO said DoDs civilian health care assessments did not consistently account for provider quality. For example, GAO found that DoD considered the quality of nearby civilian providers for only one of 11 selected military treatment facilities. Similarly, DoD did not properly consider the distance beneficiaries would have to travel to get their medical care.

Another finding was the cost effectiveness of the cuts. GAO said DoD applied assumptions that likely under-estimated the cost effectiveness of military treatment facilities.

An additional concern is the impact a 20 percent cut in military personnel would have on the battlefield. Can the services absorb these reductions and still support combat operations, humanitarian aid and relief missions?

The militarys response to COVID alone has demonstrated the key role the military can play in such a crisis. Since the pandemic began its global scourge, nearly 4400 military medical personnel have surged to augment courageous civilian medical personnel at U.S. medical facilities. This number does not include the approximately 58,000 active duty, Reserve and National Guard personnel who have also supported the response.

The Army also deployed four active-duty field hospitals.

Secretary of the Army Ryan McCarthy himself has expressed concern over the manpower cuts. He has questioned how the cuts might impact medical research facilities with resultant battlefield consequences.

DoDs attempt to affect these cuts is not well thought-out. Unlike its colleagues on the House Armed Services Committee, the Senate Armed Services Committee has not included any provisions in its version of the NDAA to halt the cuts. Accordingly, a conference committee composed of both House and Senate members will now meet to resolve this issue and several others in order to finalize the fiscal year 2021 Defense authorization bill.

North Carolinas two senators, Senators Richard Burr and Thom Tillis, even though they may not be on the conference committee, should urge their Senate colleagues to join the House in disapproving DoDs efforts to ravage military medicine.

Any reforms aimed at increasing military medical provider readiness, achieving efficiencies and improving the patient experience should be supported. But these reforms must be achieved in a thoughtful manner.

Just recently, the civilian secretaries of all the military branches, along with the uniformed heads of the services, called on Defense Secretary Mark Esper to suspend any planned moves of medical personnel or resources. They said the proposed end-state that DoD wants represents a disparate structure that hinders coordination of response to contingencies such as a pandemic.

For all the politically appointed civilian service secretaries and the uniformed service leaders to tell DoD they disagree with an action is unprecedented and speaks volumes. Hopefully, the Senate conferees, including Senators Burr and Tillis, will see the significance of this memo and act accordingly.

Tom Jurkowsky is retired Navy rear admiral who served on active duty for 31 years. He is a board member of the Military Officers Association of America (MOAA), a non-profit advocacy organization that supports a strong defense and its people. His book The Secret Sauce for Organizational Success: Communications and Leadership on the Same Page, was recently released. He lives in Annapolis, Maryland.

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U.S. Senate, including Tillis and Burr, must act to save military medicine - The Fayetteville Observer

Startup of the Week: 54gene is bringing medicine out of the dark ages – Thinknum Media

Health technology is a rapidly growing industry, and I dont think I need to explain why. Just look around you. Here we are, six months into a pandemic with little improvement in sight. How is there not a reliable treatment for COVID-19 yet? With over 24 million cases worldwide, how will the eventual vaccine be able to effectively immunize the whole world when there are still treatments for diseases from outbreaks past that dont work for many patients?

Our Startup of the Week, 54gene ($54GENE), has some answers. According to 54gene, the African genome is the most genetically diverse than all others in the world combined, yet makes up for only 3% of the data used for research and development of medicines and treatments.

At a BusinessDay panel in March, CEO Abasi Ene-Obong described the problem which 54gene addresses. Twenty-five percent of Africans cannot metabolize [a certain HIV drug], he said. Why is that? Because when that drug is being discovered and being trialed, the drug companies did not look at Africans.

By increasing access to this deep well of information, 54gene hopes to help create better medical solutions.

Thats a pitch that has investors quickly hopping aboard. 54gene is a very young company, only founded in 2019. In that short time, the company raised $4.5 million in a seed round and $15 million in Series A. With a massive pool of data at its fingertips that could have major consequences on global medicine, 54gene is the philosopher in Platos Cave, returned to a small world stuck in its ways armed with a universe of possibilities.

54genes growth shows the scale of the opportunity it has tapped into. In 2020 alone, the Lagos and Washington-based companys workforce has grown by 81 employees - a 225% increase in just six months. 54gene has managed to grow to a size that many startups take years to achieve in a fraction of the time.

54genes timing was impeccable. Breaking into the scene just before COVID-19 became a pandemic, 54gene was prepared with a solution to many of the concerns now facing the medical community. It is already involved in testing services and offers a mountain of data that could help with development of vaccines and treatments, making it easy to see why investors have quickly taken to the young company.

CEO Abasi Ene-Obong is refreshingly honest about the company goals as well. The cliche of the startup that says its making the world a better place is real and rampant, and 54gene sets itself apart by actually offering something that could positively impact the lives of patients across the planet, and by being clear about its goals as a profit-driven company.

I think [people invested in us] because they understood the potential for good. But one of the things Id like to say is that impact investment is not the same as charity, Ene-Obong said. As a company founder and CEO, I want to make money. I want to be profitable. That is one of the metrics Ill judge myself by. But at the same time, I want to do good.

Ene-Obong and 54gene are certainly on their way to accomplishing both. It is one of the fastest-growing health disruptors in the world, and has the potential to make waves across the healthcare industry on a global scale. Years down the road, you may find yourself taking a treatment and experiencing no side effects. It may be thanks to 54gene that you end up giving it little to no thought.

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UM School of Medicines Institute of Human Virology Recruits Top HIV/AIDS Epidemiologist Shenghan Lai Along with Team of Researchers – Newswise

Newswise Baltimore, MD, August 31, 2018 Robert C. Gallo, MD, the Homer & Martha Gudelsky Distinguished Professor in Medicine, Co-founder and Director of the Institute of Human Virology (IHV) at the University of Maryland School of Medicine (UMSOM), and Man E. Charurat, PhD, MHS, Professor of Medicine, Director of the Division of Epidemiology & Prevention and CIHEB Global Director at the IHV, announced today that Shenghan Lai, MD, MPH and Hong Lai, PhD, MPH, in addition to three staff members, and two more to add, have joined the Institute of Human Virology. The faculty began their positions on April 1 with Professor and Associate Professor academic appointments in the UMSOMs Department of Epidemiology & Public Health.

Dr. Shenghan Lai was most recently Professor of Pathology, Radiology Epidemiology and Medicine at the Johns Hopkins School of Medicine (JHM). He began his research in HIV/AIDS and Sexually Transmitted Diseases (STDs) in the late 1980s. His research interests include epidemiology, drug abuse, HIV/AIDS, STIs, prevention and intervention, cardiac imaging, preventive cardiology, medical consequences of HIV infection, and international health.

Dr. Hong Lai was most recently Associate Professor of Radiology at JHM. Since 2002, she has been the lead epidemiologist on five National Institutes of Health (NIH)-funded studies investigating HIV/cocaine-associated comorbidities. These include coronary calcification, left ventricular regional dysfunction, the presence and development of coronary stenosis, coronary plaque progression and cognitive decline.

We are pleased to have Dr. Shenghan Lai and Dr. Hong Lai join the Institute, said Dr. Gallo, who is also Co-Founder and International Chairman of the Scientific Leadership Board of the Global Virus Network (GVN). Together, they will add depth to our Division of Epidemiology and Prevention and provide opportunities for cross-collaborations within the Institute.

The research team led by Dr. Lai has accomplished a lot, especially for Baltimore City, said Dr. Charurat. We are excited to have them continue scientific advancements here.

Dr. Shenghan Lai has been heavily involved in epidemiology and prevention of HIV infection in countries with greater HIV prevalence for more than 10 years. He has focused on high-risk groups such as intravenous drug users, sex workers, and men who engage in sex with other men. Dr. Lai is recognized as a leading epidemiology researcher in the infectious disease epidemiology, and world renowned for his research on the effects of HIV infection and cocaine use on sub-clinical cardiovascular disease. He is the principal investigator of several NIH-supported studies, focusing on HIV natural history and cardiovascular complications of HIV and drug abuse. Dr. Lai received his degrees from Peking Union Medical College in Beijing, China, and the Uniformed Services University of the Health Sciences in Bethesda, Maryland. He has more than 250 peer-reviewed publications and numerous book chapters.

The Institute, led by Dr. Gallo, has a long history of serving the medically underserved African American population in Baltimore, said Dr. Shenghan Lai. We look forward to further exploring why HIV or other factors influence comorbidities among one of the poorest communities in this country. Our highest priority is to use science as a weapon to fight against health disparities and IHV is the best place for us to achieve our goals.

Dr. Hong Lai is the lead author of several publications demonstrating that the use of cocaine promotes subclinical coronary atherosclerosis in users with HIV infection. Further, she identified that reduced cocaine use with a cash-based incentive intervention was significantly associated with a lowered endothelin-1, endothelial marker, and reduced coronary plaque burden in chronic cocaine users with existing coronary plaques.

In addition to growing our cardiovascular research, we look forward to expanding our studies in two new areas., said Dr. Hong Lai. These include improving our understanding of how HIV, drug abuse - especially opioid - and other factors exacerbate cognitive decline among underserved population in Baltimore and reducing health disparities among Baltimores African American population.

With more than 100 publications, Dr. Hong Lais key contribution to science includes the first report that vitamin D deficiency is associated with hidden heart disease among underserved African Americans with HIV infection.

These new faculty members will provide crucial expertise in HIV to help us strengthen our departmental programs in infection control and in health disparities and population health, said Jay Magaziner, PhD, MSHyg, Professor and Chair of the Department Epidemiology & Public Health.

University of Maryland School of Medicine Dean E. Albert Reece, MD, PhD, MBA, who is University Executive Vice President for Medical Affairs and the John Z. and Akiko K. Bowers Distinguished Professor, added, I want to extend a warm welcome to these new faculty members, and I am eager to see the cross pollination that will take place as they share their expertise and enter into important research collaborations that will advance the field of HIV epidemiology, he said.

About the Institute of Human Virology

Formed in 1996 as a partnership between the State of Maryland, the City of Baltimore, the University System of Maryland and the University of Maryland Medical System, IHV is an institute of the University of Maryland School of Medicine and is home to some of the most globally-recognized and world-renowned experts in all of virology. The IHV combines the disciplines of basic research, epidemiology and clinical research in a concerted effort to speed the discovery of diagnostics and therapeutics for a wide variety of chronic and deadly viral and immune disorders - most notably, HIV the virus that causes AIDS. For more information, http://www.ihv.org and follow us on Twitter @IHVmaryland.

About the University of Maryland School of Medicine

The University of Maryland School of Medicine was chartered in 1807 and is the first public medical school in the United States and continues today as an innovative leader in accelerating innovation and discovery in medicine. The School of Medicine is the founding school of the University of Maryland and is an integral part of the 11-campus University System of Maryland. Located on the University of Marylands Baltimore campus, the School of Medicine works closely with the University of Maryland Medical Center to provide a research-intensive, academic and clinically based education. With 43 academic departments, centers and institutes and a faculty of more than 3,000 physicians and research scientists plus more than $400 million in extramural funding, the School is regarded as one of the leading biomedical research institutions in the U.S. with top-tier faculty and programs in cancer, brain science, surgery and transplantation, trauma and emergency medicine, vaccine development and human genomics, among other centers of excellence. The School is not only concerned with the health of the citizens of Maryland and the nation, but also has a global vision, with research and treatment facilities in more than 30 countries around the world. For more information, visit http://www.medschool.umaryland.edu.

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UM School of Medicines Institute of Human Virology Recruits Top HIV/AIDS Epidemiologist Shenghan Lai Along with Team of Researchers - Newswise

Improper use of PPE. Medicine to the wrong patient. Injuries from falls. A look at the problems inside Orchard Villa as COVID-19 deaths climbed -…

Orchard Villa, the Pickering long-term-care home with the most COVID-19 deaths in the province, continued to fail to comply with provincial legislation designed to protect residents even after more than 70 residents died and military personnel were sent in to assist.

As the pandemic raged on in May and June of this year, inspectors from the Ministry of Long-Term Care acting on a complaint found more than a dozen instances in which the home failed to comply with regulations, including not ensuring staff received infection control training within one week of hire, failing to ensure a resident who had fallen received a proper skin assessment, and failing to stop staff from administering a drug to a resident that was not prescribed.

These findings are in addition to more than 120 citations of failure to comply with the Long-Term Care Homes Act and its regulations between July 2015 and December 2019 recently detailedby the Star.

Since the beginning of the pandemic, 206 residents of the 233-bed Orchard Villa have been infected with COVID-19. Seventy-one residents in the long-term-care home died, and another seven died in the adjacent retirement home. More than 100 staff members have tested positive for the virus. The Durham Region Health Department declared the COVID-19 outbreak at Orchard Villa over on June 11.

In an email to the Star, Jason Gay, executive director of Orchard Villa, said during the four weeks inspectors were at the home, they reviewed a wide range of operations and found the home to be clean, with adequate PPE and other supplies.

When inspectors identified an area of improvement, action was immediately taken and most were resolved before the inspectors left the home. This action included on-going education of staff on our Falls Prevention Policy and the Skin and Wound Care Policy, he said. We are currently auditing to ensure compliance with these policies.

He added that the homes staff are hardworking and compassionate people, and they always impress us with their dedication and willingness to learn.

Sharon Navarro, a spokesperson for Lakeridge Health, which has assumed temporary management of Orchard Villa long-term-care home on June 12 for 90 days at the behest of the provincial government, said work is well underway to stabilize the homes staffing and operations and to help the facility develop the capacity to meet quality and safety standards.

In late April, when Durham Regions medical officer of health asked Lakeridge Health to lead the homes response to the outbreak, the home was significantly understaffed, said Navarro, adding that at one point during the outbreak, Orchard Villa had only 20 per cent of its full staffing complement.

She said staffing levels have now been corrected and meet current standard ratios for long-term-care homes, and that all staff and leaders receive mandatory infection prevention and control training. There is also continuous auditing of environmental cleaning, dietary compliance and hand hygiene, and PPE levels are audited daily to ensure a 30-day supply, Navarro said.

The citations for non-compliance stemming from the May and June inspections are detailed in a July 27 report and describe a wide range of problems touching on different aspects of resident care.

One notice of compliance failure issued by inspectors details the case of a resident sent to hospital after a fall. The inspection report says three staff members lifted the resident off the floor and into bed instead of using a lifting device as mandated by the homes own falls prevention and management policy. In this case, inspectors asked the home to come up with a voluntary plan of correction.

Another notice describes a complaint made to the ministry of long-term care about a resident who suffered multiple injuries due to falls, one of which resulted in hospitalization. Inspectors reviewing the residents clinical notes found that staff did not perform a skin assessment using a clinically appropriate instrument on two occasions. They also found that the home failed to ensure that a member of registered nursing staff examined the residents skin.

The report also says that while in the home, an inspector witnessed a personal support worker (PSW) helping a resident with a drink while wearing just a cloth mask and goggles even though a sign posted on the residents door directed staff to wear full personal protective equipment (PPE) including a mask, face shield, gown and gloves. The inspector interviewed the PSW, who said that they were aware of the requirements to don full PPE but used their own cloth mask due to sensitive skin to the surgical mask provided by the home.

June Morrison, whose father George died on May 3 at the age of 95 after contracting COVID-19 at Orchard Villa, said she is not surprised to learn that the home was found to have further compliance failures.

I personally think they need their licence revoked. They have proven time after time based on the inspection reports that they fail to live up to regulations and legislation, Morrison said.

George Morrison was admitted to hospital with apparent anorexia, dehydration and a urinary tract infection before his death, his daughter said.

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I dont think theyve learned anything, said Cathy Parkes, whose father Paul Parkes, an Orchard Villa resident, died on April 15 at age 86. It wasnt until three weeks after her dad died that Parkes says she learned he had tested positive for COVID-19.

Both Parkes and Morrison have filed lawsuits against Orchard Villa and its owner. They are also among 41 families calling for a criminal investigation into what occurred at the home.

Ministry inspectors also found that Orchard Villa failed to ensure staff received training within one week of hire, as required by amendments to regulations under the Long-Term Care Homes Act made in March to deal with the pandemic. The changes to the regulation mandated that training on such areas as infection prevention and control, the residents bill of rights and the homes policy on abuse and neglect of residents within one week.

Inspectors interviewed several personal support workers and registered practical nurses at Orchard Villa who confirmed that they had no training in the areas required by the regulation changes. Some said they had training on donning and doffing of PPE and hand hygiene. The ministry asked the home to write a voluntary plan of correction.

In another instance, inspectors reviewing a residents clinical records that the resident was given a medication they were not prescribed.

The licensee has failed to ensure that no drugs are administered to a resident in the home unless the drug has been prescribed for the resident, says the inspection report. It does not say what happened, if anything, to the resident.

Clearly the oversight of that facility has been in my view negligent on the face of it because you see no directors orders issued, you see no licence revocations, you see no cease admissions. That speaks to oversight that is off the rails, said Patricia Spindel, former associate dean of health sciences at Humber College and co-founder of Seniors For Social Action Ontario (SSAO), a group of social activists from across Ontario.

A directors order is issued by the director of performance improvement and compliance at the ministry of long-term care and can include revocations of licence, mandatory management orders and return of funding orders, among other things.

When you have homes in this kind of trouble and for this period of time and theres been no licence revocation, that just makes no sense to me, added Spindel.

Gillian Slogget, a spokesperson for Minister of Long-Term Care Merrilee Fullerton, said the government and its health partners continue to work around the clock to safeguard the residents and staff at the home. She said repeated non-compliance is of serious concern and can result in escalated measures and sanctions by the ministry.

Long-term care is a huge priority for our government and every option is on the table to make it better. We are forging ahead with the critical work we had underway before this pandemic hit, and will leave no stone unturned as we undertake badly needed system transformation, Slogget said.

Laura Tamblyn Watts, CEO of CanAge, a national seniors advocacy group, says the province must address the conditions we are asking our seniors to live in and that includes looking at what incentives long-term-care home owners have to respond to compliance failures.

We know that when theres consistent failure to comply and where outcomes are dangerous to residents, that there needs to be not just appropriate support but appropriate response, which means there needs to be teeth in the inspections and legislation, she said.

What weve seen with COIVD is not so much a surprise but just an illumination of the problems in the system that we always knew were there. The question is: will we now actually fix it?

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Improper use of PPE. Medicine to the wrong patient. Injuries from falls. A look at the problems inside Orchard Villa as COVID-19 deaths climbed -...

New Game Changers in Medicine Episode: Warfarin–The Life-Saving Anticoagulant That Started Out as a Rat Poison – PRNewswire

NEW YORK, Aug. 31, 2020 /PRNewswire/ --Game Changers in Medicine, the new monthly podcast from Dramatic Health, premieres its third episode, Warfarin: How a rat poison became one of the world's most widely prescribed drugson September 2, 2020. Warfarin, an anticoagulant, first came into commercial use in 1948 as a rat poison.Just four years later it was approved for medical use in the United States and went on to become one of the world's most prescribed drugs. Produced by Dramatic Health co-founder and CEO Sean T. Moloney, the series is hosted by renowned medical futurist Dr. Rubin Pillay of the University of Alabama at Birmingham (UAB).

For details on the podcast series, visit http://www.gamechangersinmedicine.comor hyperurl.co/h4jouh

The Dramatic Health and Game Changers in Medicine teams have gathered a distinguished group of experts to discuss the science and serendipity behind the discovery of warfarin. Dr. Christopher Rowan, a highly recognized cardiologist from Reno, NV's Renown Health joins the conversation, along with Kevin Walters, Historian and Strategic Research Coordinator at the Wisconsin Alumni Research Foundation (WARF); and Ramya M. Rajagopalan, Ph.D. of the Institute for Practical Ethics at UC/San Diego. Those who listened to our earlier episode on the discovery of the smallpox vaccine will recognize Dr. Paula Traktman, Professor and Dean of Graduate Studies at the Medical University of South Carolina, and formerly affiliated with the Medical College of Wisconsin.

Dramatic Health, a national healthcare video company, is the producer of the six-part podcast series Game Changers in Medicine. The series premiered in July with an episode about Vitamin K and an enterprising Boston house doctor. The August episode showcased the creation of a smallpox vaccine and its parallels to today's urgent search for a COVID-19 vaccine. Game Changers in Medicine ranked #27 in Apple Podcasts: Life Sciences in the United States according to Chartable as of August 21, 2020.Both episodes, a series backgrounder, and additional material about the podcast series are available at http://www.gamechangersinmedicine.comand can be accessed wherever you find your podcasts.

Contact: Mark G. Auerbach. [emailprotected]

SOURCE Dramatic Health, Inc.

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New Game Changers in Medicine Episode: Warfarin--The Life-Saving Anticoagulant That Started Out as a Rat Poison - PRNewswire

Premenstrual Syndrome Medicine Market to Witness Robust Expansion Throughout the Forecast Period 2020 2026 – The Daily Chronicle

Market Study Report, LLC recently added a report on Premenstrual Syndrome Medicine market that delivers a holistic view on industry valuations, market size, profit estimations, SWOT analysis and regional landscape of the market. In addition, the report points out key challenges and growth opportunities, while examining the current competitive standings of key players in during the forecasted timeline.

The Premenstrual Syndrome Medicine market report includes crucial insights regarding this business landscape and analyzes all the segments of this business vertical. The document delivers pivotal data pertaining to the key industry players and their respective gross earnings. Additionally, data regarding the regional scope and the competitive spectrum is mentioned in the study.

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The COVID-19 disease outbreak has forced worldwide governments to impose strict lockdowns. This has not only resulted in shutdown of processes and operations of various manufacturing, but also resulted in scarcity of labor. Additionally, insufficient supply of raw materials may result in modifications in terms of the expansion rate of Premenstrual Syndrome Medicine market in the subsequent years.

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Global Growth Trends:There are three chapters included in this section, i.e. industry trends, the growth rate of key producers, and production analysis.

Premenstrual Syndrome Medicine Market Share by Manufacturer:Here, production, revenue, and price analysis by the manufacturer are included along with other chapters such as expansion plans and merger and acquisition, products offered by key manufacturers, and areas served and headquarters distribution.

Market Size by Type:It includes analysis of price, production value market share, and production market share by type.

Market Size by Application:This section includes Premenstrual Syndrome Medicine market consumption analysis by application.

Profiles of Manufacturers:Here, leading players of the global Premenstrual Syndrome Medicine market are studied based on sales area, key products, gross margin, revenue, price, and production.

Premenstrual Syndrome Medicine Market Value Chain and Sales Channel Analysis:It includes customer, distributor, Premenstrual Syndrome Medicine market value chain, and sales channel analysis.

Market Forecast Production Side: In this part of the report, the authors have focused on production and production value forecast, key producers forecast, and production and production value forecast by type.

For More Details On this Report: https://www.marketstudyreport.com/reports/global-premenstrual-syndrome-medicine-market-insights-and-forecast-to-2026

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Premenstrual Syndrome Medicine Market to Witness Robust Expansion Throughout the Forecast Period 2020 2026 - The Daily Chronicle

The Married to Medicine Cast Serves as Medical Advisors at the March on Washington – Bravo

The Married to Medicine cast has come together for the health of America.

Dr. Jackie Walters, Dr. Simone Whitmore, Dr. Heavenly Kimes, Dr. Contessa Metcalfe, Toya Bush-Harris, and their significant others traveled to Washington, D.C. this week to participate in the March on Washington on Friday, August 28. The event commemoratedthe 57th anniversary of the historic March on Washington, where Martin Luther King Jr. delivered his "I Have a Dream" speech.

The Married to Medicine cast kicked off the weekend of powerful events in the fight for racial justicewith a dinner with Rev. Al Sharpton and civil rights attorney Ben Crump.

In addition to participating in the March on Washington, the Married to Medicine cast served as medical advisors at the event, offering testingfor coronavirus (COVID-19) at a mobile testing site in the city presented by America Know Your Status. "According to the CDC, there is increasing evidence that racial and ethnic minority groups, especially Black, Indigenous and Latino populations are being disproportionately affected by COVID-19," Dr. Heavenly shared in a post on Instagram in advance of the event. "Long-standing systemic health and social inequities have put many people from racial and ethnic minority groups at increased risk of getting sick and dying from COVID-19."

The initiative was organized by Dr. Heavenly's husband, Dr. Damon Kimes, who launched Georgia Know Your Status in June to help prevent the spread of the disease in his home state. Since then, they have tested thousands of patients for COVID-19 in Georgia, including hundreds at an event in collaboration with Gizelle Bryant's partner, Jamal Bryant, and his New Birth Missionary Baptist Church in Stonecrest, Georgia on August 22. Dr. Jackie, Dr. Contessa, and her husband, Dr. Scott Metcalfe, have also previously joined Dr. Heavenly and Dr. Damon in administering COVID-19 testsin Georgia.

The Married to Medicine cast also emphasized the importance of voting. "Remember to vote in the 2020 presidential election!" the Instagram post promoting the event read. "Our lives depend on it."

Dr. Jackie opened up about how meaningful it was to be able to take part in this eventin a post on Instagram on August 28."Being here was amazing but to get invited by the@real_sharpton [and] sit among VIPs was surreal! We spent our time encouraging the masses to register to vote, wear their mask and we offered covid testing@georgiaknowyourstatus," she wrote in the post."Being born is a gift but being able to make a difference and leave a mark on the earth makes us fulfill part of our purpose for being born. I give honor to God for his protection and his love to everyone!

TheMarried to Medicinecast has been active in their support of the Black Lives Matter movement and racial equality. Toyaand her sons, Ashton and Avery, have protested in support of the movement. Dr. Jackie took part in the Instagram Live panel,Amplify Our Voices: An Open Dialogue on Being Black in America, in June. Dr. Simone and Toya, as well as her husband, Dr. Eugene Harris, joined other Bravolebs in the intimate roundtable discussion,Race in America: A Movement Not a Moment, in August.

Viewers will be able to see more of the Married to Medicine cast's experience at the March on Washington in the upcoming Season 8.

All photos courtesy of Dr. Heavenly Kimes; Dr. Simone Whitmore; Dr. Contessa Metcalfe

For the latest reporting on the Black Lives Matter movement fromNBC Newsand MSNBCs worldwide team of correspondents, including a live blog with minute-to-minute updates, visitNBCNews.comandNBCBLK.

The Daily Dish is your source for all things Bravo, from behind-the-scenes scoop to breaking news, exclusive interviews, photos, original videos, and, oh, so much more. Subscribe to The Daily Dish podcast, join our Facebook group, and follow us on Instagramfor the latest news hot off the presses. Sign up to become a Bravo Insider and be the first to get exclusive extras.

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The Married to Medicine Cast Serves as Medical Advisors at the March on Washington - Bravo

University of Medicine and Health Sciences Launches Dextrocardia Podcast – PR Web

Dextrocardia is a medical term for when your heart is the other way around. Caribbean medical schools have many misconceptions, but this podcast might just help you look at things from the other way around.

New York, NY (PRWEB) August 31, 2020

University of Medicine and Health Sciences (UMHS), a small, mission-driven medical school with a commitment to student support and a legacy of successful residency placements in the United States and Canada, today announced the launch of Dextrocardia, a new podcast that explores life as a medical student in the Caribbean. Produced by UMHS and hosted by second-year medical student Nihal Satyadev, the series will feature conversations with fellow medical students, UMHS faculty, and medical practitioners and focus on the unique challenges faced by Caribbean medical students in the era of COVID-19, career advice, and the role of healthcare workers in the context of social justice issues and the Black Lives Matter Movement. The first episode is now available at https://dextrocardia.podbean.com/ and all major podcast platforms, including Apple, Google, Spotify, and YouTube.

As the most popular alternative path to becoming a doctor in the United States and Canada, the journey of a Caribbean medical student is fraught with ups and downs. From sleepless nights studying to the overwhelming relief upon passing the all-important Step 1 exam and the euphoria of matching into a dream residency, Dextrocardia tells this story through conversations with medical students, faculty, and healthcare practitioners. The series seeks to dispel common misconceptions about Caribbean medical schools and impart practical advice to students in Basic Science, clinical rotations, and undergraduate programs.

Dextrocardia is a medical term for when your heart is the other way around, said podcast creator and host Nihal Satyadev. Caribbean medical schools have many misconceptions, but this podcast might just help you look at things from the other way around.

Prior to enrolling at UMHS, Satyadev earned his Masters in Public Health from George Washington University and a BA from the University of Redlands. A social entrepreneur and Alzheimer's advocate, Satyadev is the CEO and co-founder of The Youth Movement Against Alzheimer's, a 501(c) 3 nonprofit organization providing opportunities for college and high school students to advocate, research, and provide care for those battling with the disease. Satyadev has also published research assessing the correlation between Alzheimers Disease and periodontal disease.

Episode 1 of the series features Satyadevs interview with UMHS student Stephanie Vang. In this premiere episode, Vang discusses her work as a teachers assistant (TA) for anatomy and shares advice for fellow students about what it takes to get an A in the class - a standard course taught in the Basic Science portion of medical school.

Discussion topics for upcoming episodes include:Conversation with an Anatomy TA Conversation with a Histology TAConversation with a Neuroscience TAConversation with a Biochemistry TAMedical Research - How medical students can pursue researchBlack Lives Matter - How medical students can get involved, plus a deep dive into racial inequities in healthcare, medicine, and medical education

Dextrocardia is now available on Apple Podcast, Google Podcast, Spotify, and YouTube with new episodes dropping on alternate Tuesdays at 5 am EST. To access the latest episodes and information about the podcast, visit https://dextrocardia.podbean.com/.

About UMHSThe University of Medicine and Health Sciences (UMHS), is a small, mission-driven medical school with a commitment to student support and a legacy of successful residency placements in the United States and Canada. UMHS was founded in 2007 by medical education pioneers Warren and Robert Ross to deliver a highly personalized school experience. Graduates of UMHS earn a Doctor of Medicine degree (MD) and qualify to practice medicine throughout the United States and Canada. Students begin their Basic Science studies in St. Kitts, West Indies, and complete their clinical training in the United States. With an unprecedented 96% student retention rate, the vast majority of students that begin their medical studies at UMHS go on to obtain residencies. For more information visit https://www.umhs-sk.org/.

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University of Medicine and Health Sciences Launches Dextrocardia Podcast - PR Web

SPORTS MEDICINE: In NBA bubble concussion acumen absent – The Times of Northwest Indiana

The Panthers Kawann Short, an E.C. Central grad, has played a key role on the defensive line.

The big, bold and colorful mural on the outside wall of Columbus Drive Gyros hits you like a storm surge while entering the building.

Its a life-size painting of hometown hero Kawann Short, defensive tackle for the Carolina Panthers, in his No. 99 uniform and holding the Super Bowl 50 trophy triumphantly in his right hand, an event that was not to be.

Throughout Northwest Indiana, there were banners, posters and pep rallies throughout the city in support of the E.C. Central grad. Social media kept him in touch daily with the Region, as if he were standing at the corner of Chicago Avenue and Indianapolis Boulevard, taking it all in.

One particular banner stretched across Columbus Drive at Alder Street, proclaimed: East Chicago is proud of our hometown Kawann Short. We are East Chicago Super Bowl 50. Go Panthers!

That 10-by-10-foot mural at Columbus Drive Gyros was painted Jan. 28 by the artist known as Fhat Cousins, who worked on his labor of love for eight hours.

Im 6-foot, and I still have to look up at it, said restaurant owner John Troupis. Its a win-win for the city because it went viral on social media. People are always pulling up, taking pictures of it.

Kawann loved it and ended up sharing it (on social media). It lit a fire under everybody to join the celebrating.

E.C. Central and middle school football players watched the 2016 Super Bowl in the high schools mini-theater, with a pre-game video message delivered by Kawann Short.

Ive seen so much of the love coming from home. Its sincere and coming from the heart, he said by phone prior to the game. East Chicago isnt very big. It has only about 30,000 but they respect people who get out and do things with their lives.

And when you do, they gladly jump on board and support you 100 percent.

The 44th overall pick in the 2013 draft, Short went from five sacks combined over his first two seasons to an eye-popping 11 in 2105-16 a team record for defensive tackles before the NFL championship game.

But what really jumps out to students of the game is 11 sacks, 55 tackles and three forced fumbles by a 4-3 interior lineman who also is a fierce pass rusher on the edge.

Short has transformed from a player who flashed across the screen once a game to a surefire Pro Bowler.

Im just out here doing what Im doing and trying to help this team win. Its the only thing I can ask or work for, said the 6-foot-3, 315-pound Short.

Short has partnered with Athletes for Charity, HealthLinc and the East Chicago Fire and Police Departments to create academic incentives to benefit youth. Hes launched a Youth Literacy Project to deliver books and academic incentives to children in need of encouragement when it comes to reading and academic achievement.

They always come back. Theyve never forgotten about their city and thats whats so great, said Steve Segura, multimedia director of East Chicago.

Getting involved, sending a positive message, can work wonders in any environment.

Some guys play this game 16-17 years and havent been to the Super Bowl. Ive played three years and Im here, said Short, who had a video message for the citys football players watching Super Bowl 50 game at the high school:

Ive been in your position and in the same seats many years ago. I had a vision and a dream to be where I am today, Short said. East Chicago ... you guys have been behind my back 100 percent. I appreciate you guys for being there, showing love and support. Youve been amazing. Have a blessed day.

As kids, ETwaun Moore and Short often stopped at Columbus Drive Gyros for a quick bite after school. It was a popular hangout with their basketball teammates.

ETwaun was the star point guard and Kawann a power forward on the Cardinals 2006-07 team. Owner John Troupis recalled how the players, prior to sectionals, had assured him they were going to win the 4A championship.

He made a deal. Win state and its all you can eat.

The Cardinals advanced through the tourney knocking off Lowell, Munster, South Bend Adams, Valparaiso and Marion for a shot at Indianapolis North Central, featuring high school phenom Eric Gordon.

E.C. Central prevailed, 87-83.

It wasnt long after when Moore and Short, holding the trophy, led the Cardinals into Columbus Drive Gyros and said: Were really hungry!

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SPORTS MEDICINE: In NBA bubble concussion acumen absent - The Times of Northwest Indiana

Anti-covid-19 medicines are being approved too easily – The Economist

Aug 29th 2020

WHAT DO A malaria drug, a Russian vaccine and the blood plasma of people who have recovered from covid-19 have in common? All have been approved for use by governments in response to the coronavirus pandemic, with little or no scientific substance to back those decisions up.

On March 28th, near the pandemics beginning, Americas Food and Drug Administration (FDA) issued emergency-use authorisation for hydroxychloroquine, an established but not risk-free antimalarial medicine which was controversially being proposed by some people, including Donald Trump, the countrys president, as a possible covid treatment. It did so, the authorisation stated, based on limited in vitro and anecdotal clinical data. On August 11th Vladimir Putin, Mr Trumps Russian counterpart, said his government was the worlds first to approve a coronavirus vaccine, despite a lack of proper tests. And on August 23rd Mr Trump announced approval of the use of convalescent plasma therapy to treat covid-19. He described it as a very historic breakthrough on the basis of a study the statistics of which the head of the FDA, Stephen Hahn, got publicly and spectacularly wrong.

That regulators move fast in emergencies is to be applauded. But these three examples have raised worries that sometimes they are moving too fast, and possibly for the wrong reasons. In one instance, indeed, things have gone full circle. Hydroxychloroquines approval was rescinded on June 15th, after a series of well-conducted trials showed that it had no effect on covid-19. The worry is that the other two approaches may prove similarly futilediverting attention and effort from more promising avenues or, worse, causing actual harm.

The Russian announcement was of the development, by the Gamaleya Research Institute of Epidemiology and Microbiology, in Moscow, of Sputnik V. This involves two injections, three weeks apart (see chart). Each shot is of a harmless virus that has been modified to express one of the proteins made by SARS-CoV-2, the virus that causes covid-19. This is a perfectly sensible approach. Unfortunately, Sputnik V has not yet been through the trials, normally involving many thousands of people, which would be needed to show that it works and is safe. In fact, it has been given to a mere 76 people, and no results from these tests (nor from any of the animal tests that the institute says it has run) have yet been published. Mr Putin has, in other words, simply redrawn the finishing line for making a vaccine, stepped over it, and declared victory.

Americas behaviour is not much better. Again, the approach behind the product approved is reasonable in principle, but insufficiently tested. Convalescent plasma therapy transfuses blood plasma from those who have recovered from an infection (and which is therefore rich in antibodies against whatever had infected them) into patients with the illness to be treated. As Soumya Swaminathan, chief scientist of the World Health Organisation (WHO), observes, this tactic has been used to treat infectious diseases for over 100 years, and is effective against some, but not others. Trials of it as a treatment of covid-19 are therefore under way around the planet, but Dr Swaminathan says the results so far are not conclusive, and the trials themselves have been small. As a result, the WHO considers it an experimental therapy.

Not so, apparently, the FDA. Mr Trump made his announcement with Dr Hahn on the same platform. Two things have upset people about this. One is that the basis for the emergency approval was an observational study of ways of administering plasma (either less or more than three days after diagnosis) rather than a randomised controlled trial in which some patients were given a placebo instead of the treatment under test. The other is that, even granted this difference, the advantage seen in the study in question was too inconclusive to justify the approval given.

Dr Hahn described the benefits of treating early with convalescent plasma by saying that, if the data continue to pan out, [of] 100 people who are sick with covid-19, 35 would have been saved because of the administration of plasma. Jonathan Reiner, a professor of medicine at the George Washington University Medical Centre, tweeted that this was shockingly wrong, and that the actual figure was 3.2. Dr Hahn has since clarified that he confused the relative reduction in risk of mortality (of 35% between the two arms of the study) with an absolute risk reduction. That is a pretty fundamental mistake.

Meanwhile, in Hong Konga part of the world which looked as though it had SARS-CoV-2 under controlnews has emerged of someone who, having had covid-19 once and recovered, has now been infected by a slightly different strain of the virus. Extrapolating from a single case is risky, but this one calls into question how long someone who recovers from infection retains immunity from re-infection. The answer is crucial to understanding how herd immunity to the virus develops in populations, and may also have implications for vaccine development. Doctors will now be looking hard for similar examples, so that such understanding can be improved.

Editors note: Some of our covid-19 coverage is free for readers of The Economist Today, our daily newsletter. For more stories and our pandemic tracker, see our hub

This article appeared in the Science & technology section of the print edition under the headline "Trials and tribulations"

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Anti-covid-19 medicines are being approved too easily - The Economist

University Orthopedics Welcomes Dr. Andrew Chen to Sports Medicine Team – OrthoSpineNews

EAST PROVIDENCE, R.I. (August 25, 2020) University Orthopedics (UOI) today announced the addition of Dr. Andrew Chen to its renowned Sports Medicine team.

As the leader of comprehensive orthopedic care in the region, UOI is committed to providing enhanced outcomes for all patients experiencing acute and chronic pain and injury. The addition of Dr. Chen will help to ensure that all patients requiring non-surgical treatment continue to receive the highest quality orthopedic care available.

We are thrilled to welcome Dr. Chen to the practice, said Edward Akelman, M.D., President of University Orthopedics. Just like all of the clinicians at University Orthopedics, Dr. Chen is committed to a higher level of patient care. This dedication to enhanced patient outcomes is at the heart of our practice and will make him an additional asset to our Sports Medicine team.

Dr. Chens specialty is Primary Care Sports Medicine. He treats a wide range of sports-related injuries including finger, hand, and wrist injuries; elbow issues; shoulder issues and pathologies; hip pain and injuries; knee pain and injuries; and ankle and foot problems. Dr. Chen will also treat chronic tendinopathies and injuries that have failed conservative management.

I take pride in not only helping my patients recover from an injury, but also returning them to optimum health so they excel in the sports and activities they love, Dr. Chen said. I am honored and humbled to be joining such an experienced and well-regarded team like the one at University Orthopedics.

Dr. Chen recently completed a fellowship with Case Western Reserve University at University Hospitals Cleveland Medical Center. He holds an undergraduate degree from Carnegie Mellon University and an MD from Jefferson Medical College. Additionally, he is board-certified in family medicine through the American Board of Family Medicine. He has served as team physician for Kent State University, Lake Erie College, and Hawkin Upper School, which is a college prep school in Ohio.

Dr. Chen is joining UOI September 1 and will eventually be located at UOIs new Mansfield, Massachusetts location when it opens in January 2021.

About University Orthopedics

University Orthopedics (UOI, universityorthopedics.com), with clinic locations in Barrington, East Greenwich, East Providence, Johnston, Providence, Middletown, North Providence, and Westerly, is a regional center for orthopedics, sports medicine, and rehabilitation. UOI includes more than 40 board-certified orthopedic, fellowship-trained musculoskeletal and sports medicine physicians. These specialists are faculty members of the Department of Orthopaedics at the Warren Alpert Medical School of Brown University who teach medical students, orthopedic residents, and fellowship sub-specialty surgeons.

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University Orthopedics Welcomes Dr. Andrew Chen to Sports Medicine Team - OrthoSpineNews

Writer, heal thyself An Irishmans Diary on literature and medicine – The Irish Times

As a self-published writer with a comic novel and two column collections to my name, I have little time for the precious sensibilities of the traditional publishing industry, now competing with a new generation of DIY authors as well as the sales-inhibiting effects of Covid.

What moves me to despair instead especially at this time of year, when we should be reclining on a sun-baked beach in the Algarve, book in hand is the number of bestselling authors who consider the application of pen to paper (or fingertip to laptop key) their secondary vocation. These include the usual suspects: athletes, politicians, actors, and celebrity chefs.

The medical profession, however, harbours a high percentage of these double-jobbers, as any sanctioned visit to your favourite battened-down caravan park or jellyfish-infested beach will confirm. (Provided your mask doesnt slip, of course, and you can safely observe your fellow holiday-makers preferred reading matter before its whipped from their hands and tossed into the sea by a rogue gust.)

On the fiction side, the bestseller lists regularly feature the medical thrillers of Robin Cook, Tess Gerritsen, and Irelands own Paul Carson, all med-school grads and one-time medical practitioners.

On a more contemporary note, neuroscientist Lisa Genova tapped into our anxiety around neurological disorders when she self-published her first book, Still Alice, in which a 50-year-old college professor is afflicted with early-onset Alzheimers. (Julianne Moore starred in the film adaptation and won the 2015 Best Actress Oscar for her portrayal of the title character.) In subsequent novels, Genova has dealt with autism and Huntingtons Disease.

But the grandaddy of literary MDs has to be the legendary and now departed Michael Crichton, who chose not to practise and instead became a one-man entertainment industry whose catalogue of accomplishments includes the TV series ER and the multi-media phenomenon Jurassic Park.

Not to be outdone, the non-fiction list also offers an intriguing line-up. Here we have medics who do indeed handle their words with a surgical precision: Lewis Thomas, Jerome Groopman, and perhaps the dean of medical writers, Oliver Sacks, whose 1973 book Awakenings provided the material for the Oscar-nominated film of the same name.

But theres one moonlighting MD who really worries me. His name is Atul Gawande and hes a general surgeon at Brigham and Womens Hospital in Boston as well as a professor at Harvard Medical School and the Harvard TH Chan School of Public Health.

Dr Gawande is also a staff writer for the New Yorker and has scooped two National Magazine Awards. Plus, he was featured a few years ago as one of Time Magazines 100 Most Influential People, a position a literary wannabe like me will never occupy no matter how many people I desperately attempt to befriend on Facebook.

The good doctor is primarily an essayist, a form I, too, have come to favour in recent years for its brevity and versatility. His writing is so good and displays such insight and understanding that Im tempted to turn the tables and perform a couple of routine surgical procedures. (Im sure theres a YouTube video I could consult.)

The exalted status of Dr Gawande and his peers is exceptional, though.

Most writers are happy to plod along in a different sphere.

According to US Labor Department figures, the average writer earns just over $20 an hour for his or her efforts. Now, 20 bucks an hour might seem a paltry sum. But when you consider that a writer might spend half of every working day surfing the internet or heading to the kitchen for a snack or staring out the window for inspiration so Im told that wage starts to look pretty good.

As for the average income of Irish writers, thats harder to pin down. (I gave up after a 10-minute Google search anyway.) But the fact that theres a tax exemption scheme for writers seems to me a clear admission that the returns are going to be pretty low if you decide to pen a novel, play, or short story.

The way I see it, then, traditional versus DIY publishing isnt the issue. Nor is it online shopping versus the face-to-face retail experience.

For literary practitioners like me, its those darn bestselling book docs.

So please, gentlemen and ladies, look at it from our side. Despite what I said earlier, struggling writers can hardly go out and earn a little extra cash by performing life-saving surgery or overseeing vital psychiatric therapies.

Whereas the way the worlds going, practising medics will never be out of work.

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Writer, heal thyself An Irishmans Diary on literature and medicine - The Irish Times

Flint physician focused on advocacy named Michigan Family Medicine Resident of the Year – mlive.com

FLINT, MI Dr. Julie Thai of McLaren Flint said she went into medicine to help her patients not just medically, but in a social context as well.

When I hear my patients stories about how theyre struggling to pay for rent or theyre struggling to find childcare so they can even go to work or come to their medical appointment, I feel compelled to help them, Thai said. When things are unfair in the healthcare system and my patients cant get access to the medications they need or diagnostic workup, I feel that I have this platform I can use to advocate for them.

Advocacy has been the central theme of her training in Flint, Thai said. She is in her final year of residency at McLaren Flint Family Medicine Residency and was recently recognized with a 2020 Michigan Family Medicine Resident of the Year Award by the Michigan Academy of Family Physicians. Not long before, she received the Association of Family Medicine Residency Directors Family Medicine Resident Award for Advocacy.

I try to do everything I can for my patients not only as their physician, but as their advocate. So as part of that, I was recognized for my work and that means a lot, Thai said. I am so fortunate to get to do what I love to do, and to be recognized for what I love to do is a huge honor.

Thais program director, Dr. Prabhat Pokhrel, nominated her for the award and said she has made a tremendous contribution to the Flint community. He said the advocacy and health policy curriculum she co-authored after completing a workshop with the Michigan Academy of Family Physicians has been built into the McLaren Flint Family Medicine Residency program and taken to the next level. The curriculum is getting state and national attention, and a toolkit has been made available for other residency programs looking to replicate it.

Before she came, we didnt have any advocacy curriculums, Pokhrel said. She came up with this idea.

Thai holds a masters degree in public health from Columbia University and went into research before deciding to become a physician. She said she felt an urge to do more public health and public service work, and came across the Michigan Academy of Family Physicians workshop by chance.

That was a life-changing moment for me because I got to hear from a lot of the people who work at the Capitol about physicians getting involved in advocacy work. And it made me feel empowered, because I realized that we are put in a position where we do have a voice where people do listen to us, Thai said. I felt that I had to speak up, I had to be a part of the group that fights for change. And I just never stopped doing it.

Thai attended Senate committee hearings on prior authorizations and said allowing insurance companies to dictate how physicians practice medicine is something she wants to fight against on a policy level, since she said a lot of their patients cant get the medication they need. In addition to pushing for change, Thai is conducting a study on the barriers to breastfeeding in the community after noticing a lot of new mothers at McLaren werent breastfeeding despite national recommendations.

I read some research that in a lot of urban underserved communities, moms dont tend to breastfeed because there isnt a lot of education around it, Thai said. That got me thinking about trying to identify barriers to breastfeeding in our community in Flint.

The survey study was approved by the Institutional Review Board at McLaren and is being conducted by Thai and two other faculty members.

Ive collected close to 100 questionnaires already from moms, and most of them want to participate, most of them want to share their experience, Thai said. It helps us figure out what is stopping them from breastfeeding and how we as healthcare providers can help increase the rate of exclusive breastfeeding in this community.

Thai is originally from California and came to Michigan by way of medical school, earning her degree from Michigan State University College of Human Medicine in 2018.

I really feel like Michigan has become a second home to me, she said. When I matched here in Flint, I thought this would be an amazing opportunity to learn how to provide care in an urban underserved community, similar to one that I grew up in.

Thai was elected by her peers and faculty at McLaren Flint Family Medicine Residency to serve as academic chief resident for the 2020-21 program year. She previously served as the programs assistant chief resident. Thai said shes thankful for Pokhrels support and the support shes received from hospital leadership as well as from her patients. After completing her residency training next year, she plans to pursue a fellowship in geriatrics.

The impact has been immense. The things Ive gotten to do here have shaped me as a person and as a professional, Thai said. A lot of my patients, when they tell me that they view me as not just their physician but as their friend, I feel very moved by that. I feel as though thats all Ive ever wanted, to have that meaningful patient-doctor relationship and be able to help individuals through a tough time in their life.

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Flint physician focused on advocacy named Michigan Family Medicine Resident of the Year - mlive.com

INCB, WHO and UNODC statement on access to internationally controlled medicines during COVID-19 pandemic – World Health Organization

Scope (COVID-19 and non-COVID-19 patients affected by the pandemic)

The International Narcotics Control Board (INCB), the World Health Organization (WHO) and the United Nations Office on Drugs and Crime (UNODC) call on governments to ensure that the procurement and supply of controlled medicines in countries meet the needs of patients, both those who have COVID-19 and those who require internationally controlled medicines for other medical conditions.

There is a need to ensure access to controlled medicines such as sedatives and analgesics for intubation protocols for the treatment of patients with COVID-19. Non-COVID patients continue to require controlled medicines for the management of pain and palliative care, surgical care and anaesthesia, mental health and neurological conditions, and for the treatment of drug use disorders.

It is important to remember the needs of existing patients who require controlled medicines for the management of these health conditions. These patients faced barriers to accessing controlled medicines before the COVID-19 pandemic. The COVID-19 pandemic has further resulted in interruptions of the medicines supply chain, and it is critical that access to essential health services and medications not be forgotten or de-prioritised during this pandemic.

As the pandemic increasingly affects countries with under-resourced health infrastructure and services, it is an ethical imperative to ensure that all people in all countries of the world are able to access essential medicines. This includes those medicines that are under international control.

Governments should ensure that sufficient quantities of internationally controlled medicines, of assured quality, are available and affordable to people under medical care. Throughout the duration of the pandemic and beyond the acute phase of burden on the healthcare infrastructure, it is critical that governments work cooperatively to ensure that no country, no region, no district, no city and no patient is left behind. Competent national authorities, manufacturers, suppliers and distributors play a crucial role in ensuring that internationally controlled medicines urgently needed for medical treatment are available within and across national borders. The supply chain is the foundation of quality medical care because without the necessary supplies, including essential controlled medicines, patients will suffer.

Governments are reminded that in acute emergencies, it is possible under the International Drug Control Conventions to utilize simplified control procedures for the export, transportation and supply of medicinal products containing controlled substances, especially in those cases where the competent authorities in the importing countries may not be operating at full capacity. Competent national authorities may permit the export of medicines containing narcotic drugs and/or psychotropic substances to affected areas even in the absence of the corresponding import authorizations and/or estimates. Urgent deliveries do not need to be included in the estimates of the receiving countries affected by emergencies. When possible, competent national authorities are also encouraged to issue electronic import and export authorizations through the INCB International Import and Export Authorization System (I2ES), PEN Online and share related contingency measures in the forum therein.

Countries should ease COVID-19 related transport restrictions for controlled medicines and consider local production solutions when feasible, to meet the COVID-19 driven demand spikes.

To assist countries as they work to find solutions to the lack of access and availability of controlled medicines, the three organizations suggest the following technical assistance and support documents:

The work of doctors, nurses, and health care professionals in general, who provide treatment and care to people including the most vulnerable, needs to be supported and safe and effective medicines should be available, accessible and affordable at all times for people who need them.

INCB, WHO and UNODC are committed to continue to work together to address this critical issue and will expand joint efforts to engage with other partners and increase advocacy and technical assistance to countries for improving access to controlledmedicines during the COVID-19 pandemic and mitigate barriers to ensure that both patients affected by COVID-19 or by other non-COVID-related conditions requiring medicines under international control have access to these medicines when they need them.

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INCB, WHO and UNODC statement on access to internationally controlled medicines during COVID-19 pandemic - World Health Organization

AINsight: Aviation Medicine in the Pandemic, Part 3 | Business Aviation – Aviation International News

The entire world continues to learn new adaptations and strategies to cope with the Covid-19 pandemic, with ongoing changes occurring literally on a day-to-day basis. Will children return to public schools at all this coming year? Many college sports seasons are now canceled entirely. Most of the remaining professional sports events are being played without spectators.

The most disappointing to me personally is being unable to go scuba diving nor make my near-annual trek to The Masters. But if I am healthy enough to lament the small stuff, then at the same time I need to feel grateful and fortunate. That remains something that I focus on during some of the ongoing frustrations and disappointments.

If I or family, friends, and colleagues are healthy, then we have plenty to be thankful for. Hopefully, in time, the societal burdens due to the pandemic will lessen. We all must exercise patience along the way.

All businesses are making adjustments, including those involved in both corporate and airline flight operations. At one moment there is some small optimism that airline bookings are improving, and then come the dire furlough warning letters being issued.

Aviation medicine is making adjustments, too. The FAA has realized that the process of obtaining a medical certificate is hindered by the pandemic, both in regard to the routine logistics of doing so and also for the inherent exposure risks to pilots and their AMEs.

In recent blogs, I discussed the adjustments being made regarding medical certificate extensions. The original ruling simply stated that the FAA would not take legal action against a pilot who continued to fly in non-compliance with medical certificate durations (for up to three months) as outlined in FAR 61.23. In other words, the pilot is knowingly breaking the rules, but no enforcement action will be initiated against that pilot.

More recent FAA clarifications have occasionally used softer wording, in that the validity period of the medical certificate would be extended by the noted three months (even though the non-compliance wording remained the seemingly controlling verbiage). Regardless of the ongoing nebulous nature of the wordings, all recent FAA statements make it clear that the FAA has sanctioned flying for up to three months beyond the typical medical certificate durations outlined in the FARsat least for the time being.

A special FAR (SFAR 118-1) was published on June 29, noting an effective date of June 25. This SFAR provides relief for both medical and operational certification date requirements. The FAA sent clarifications to AMEs on July 1, referencing some of the provisions of the SFAR.

The FAA notes that more than 57 percent of AMEs are over the age of 60, a demographic at higher risk of severe effects from Covid-19. I am one of that aging lot, but have continued to operate my office full time to support my pilot clients. My staff and I have made several accommodations to comply with accepted medical practices for reducing the risk of transmission of Covid-19.

These accommodations are somewhat inconvenient, of course, but we are happy to do our part to reduce risks to everyone. Pilots who come to my office have been all over the world and will soon leave to points afar once again. I do not want them to get sick from being in my office, and similarly, I do not want my staff or myself to get infected with Covid from a pilot who may be an asymptomatic carrier of the disease.

We cannot lead our lives in complete fear and paralysis, but prudent behavioral modifications and interventions are worth complying with while the virus situation is being sorted out.

In a more recent clarification to AMEs, dated July 7, the FAA stated that the non-enforcement of expired medical certificates is a rolling 90-day action. While again, there remained no true use of the word valid, the FAA does clearly support that medical certificates may be used for an additional three months.

However, the final rolling action timeline stated is that certificates that would normally expire Sept. 30, 2020, will now be in a non-enforcement status until Dec. 31, 2020. No extensions are stated beyond that date in this most recent guidance.

There is no way for me to predict whether the FAA will extend medical certificates yet again, beyond these stated dates. If they do not, the AME might be burdened with the expectation to perform up to three months of exams in December. I know that I will not have time to do that, and many of the other still-working AMEs may not either.

I recommend that pilots plan their renewal dates carefully and check with their AMEs well in advance to see if there will be available scheduling time should the pilot elect to fly beyond the usual expiration date of their existing medical certificate.

There remains confusion regarding how to handle expiring special issuances. These authorizations require a time limit to be placed directly on the medical certificate itself, stating that the certificate is not valid for any class after a specified date. This limitation, directly stated on the medical certificate, makes it impossible for me (or the aviation advocacy groups) to provide a blanket statement to pilots that it is OK to fly beyond that date. We have asked for more specific clarification on this from the Federal Air Surgeon, but so far there has been no formal guidance issued to AMEs.

While awaiting more specific guidance from the Federal Air Surgeon, the process for the AME to obtain a one-time case-by-case extension of a special issuance for a pilot requires direct communication with an FAA physician. This process itself is too involvedand is sometimes frustrating and time-consumingto discuss in this blog, and I encourage pilots to ask their AMEs to do so only if it has been truly impossible to obtain the required data as specified in the special issuance authorization.

The FAA continues to state on its website: If you are able, we continue to encourage airmen to accomplish their regularly required airman medical certificate exam with an FAA AME as per normal scheduling and FAR requirements. The extensions exist, but everyone involved, from the FAA to the AME, understands that pilots should stick to their normal renewal cycle if at all possible.

The requirements of FAR 61.53 are not waived by any of the advertised medical certificate extensions. As you know, FAR 61.53Prohibition on operations during medical deficiencyrequires pilots to self-ground should there be a new condition of aeromedical concern, worsening or exacerbation of an existing condition (which may already be addressed in a special issuance authorization), and/or if new medications of potential concern are prescribed (or may simply be non-prescription medications being taken on an over-the-counter basis, but have effects that would not be compatible with aviation safety).

Therefore, if a pilot has a new medical situation that may otherwise preclude the issuance of a medical certificate (or may be theoretically grounding at any other time), the extensions cannot be used as a vehicle to continue flying regardless of the new medical concerns. FAR 61.53 applies at all times that a pilot intends to exercise the privileges of a medical certificate, without exception.

I express hope that pilots, their families, ancillary aviation workers, and vendors, and, of course, we aging AMEs and our staff members, all maintain health during these troubled times. I also hope that the world economy recovers and that once again there will be a more prosperous and optimistic future ahead of us.

Lets support each other along the way, and be thankful for the health afforded by being careful and responsible with virus mitigation protocols.

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AINsight: Aviation Medicine in the Pandemic, Part 3 | Business Aviation - Aviation International News

Support the Badger-Two Medicine Protection Act – Flathead Beacon

Opinion | LetterThe Badger-Two Medicine represents one of the largest unprotected roadless areas in the lower 48 states

By Louis Bruno // Aug 14, 2020

I am a retired school teacher and professional naturalist guide. I have lived at the foot of the Badger-Two Medicine for the past 45 years.

The Badger-Two Medicine represents one of the largest unprotected roadless areas in the lower 48 states. Taken on its own, it represents some of the finest wildlife habitat in the United States. It serves as critical habitat for moose, elk, grizzly and black Bear, wolf, mountain lion, westslope cutthroat trout and countless other sensitive species. When you consider its position in the Northern Continental Divide Ecosystem, it is crucial to its biological integrity. It also serves as the spiritual anchor for Blackfeet culture.

In 1984, I and other local residents, both tribal and non-tribal, formed the Glacier-Two Medicine Alliance in response to the threat of oil and gas development. The U.S. Forest Service provided a map showing a scenario of development for the area over the next 10 years. It showed 23 gas wells with inter-connecting roads and a gas processing plant in the center of the unit. Such development would have totally destroyed the area for recreation, wildlife and Blackfeet use for spirituality. The Blackfeet and other Montana citizens have spent the past 45 years advocating for a wild Badger-Two Medicine. In the ensuing years, countless United States citizens have urged protection for this area. Such upwelling of public support for protection led the Secretary of Interior to place a moratorium on future oil and gas leases in the area.

The Badger-Two Medicine Protection Act would permanently protect this area from industrial development. For this reason, I urge everyone to support this crucial piece of legislation.

Louis BrunoEast Glacier Park

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Support the Badger-Two Medicine Protection Act - Flathead Beacon

Kyiv-based Liki24, an e-commerce platform for medicine delivery, raises 4.2 million to expand internationally – EU-Startups

Liki24, a Ukraine-based e-commerce platform for medicine delivery, has raised around 4.2 million from Horizon Capital and existing investors, bringing total funding raised to date to approximately 5 million. This new equity round will support the startups ambitious European expansion plans, with Poland being the first international market where Liki24 launched operations last month.

Founded in 2017, Liki24.com is a marketplace aggregating offers from thousands of pharmacies and facilitating transactions between pharmacies and consumers. Liki24 launched in Ukraine first, addressing three consumer pain points: significant variation in pricing among market players, limited availability of medicines in one point of sale, and lack of home delivery. In less than 3 years since inception, the company has connected 5,000+ pharmacies and completed over 500,000 orders powered by a proprietary software system that integrates with pharmacies ERPs, instantly analyzing prices and availability of medicines, developing optimal routes for couriers, thus allowing for rapid delivery to customers at affordable prices. Today, Liki24 has been described as a lifeline for the most vulnerable consumers, often the only viable option for the elderly to receive medicines, as well as people with limited mobility and those living in remote areas.

Liki24 played a crucial role during the coronavirus lockdown in Ukraine to ensure people sheltering at home had access to lifesaving medication. The company partnered with local logistics operators to offer free delivery of medication during the quarantine.

Our business model proved to be successful in Ukraine, helping customers access more affordable medicines and convenient delivery. This capital raise will enable us to expand our team as well as extend our winning model to the Polish market and finance further international expansion at a time when safe and rapid delivery of medication is critical to the wellbeing of society, commented Anton Avrinsky, CEO and founder of Liki24.

Horizon Capital is delighted to partner with Liki24 talented founders and join the companys impressive existing investor base. We look forward to contributing to the companys continued growth in the years ahead. Liki24 has an attractive mix of elements crucial for success, including strong founders with a bold vision, drive and demonstrated execution-ability, backed by a highly professional management team. Our investment in Lik24 is consistent with our focus on visionary founders with a clear expansion strategy who seek out a partnership with Horizon Capital to reach new heights, said Lenna Koszarny, Founding Partner and CEO at Horizon Capital.

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Kyiv-based Liki24, an e-commerce platform for medicine delivery, raises 4.2 million to expand internationally - EU-Startups

Why ‘Zoom medicine’ is not the answer to all our ills – The Guardian

Telemedicine has arrived in the NHS. The pandemic has seen a dramatic shift in the provision of healthcare, away from in-person appointments and towards remote arrangements. While this might appear to be a temporary measure for social-distancing purposes, at the end of last month, the health secretary Matt Hancock, said the changes are here to stay. The UK needs more Zoom medicine, he said, telling the Royal College of Physicians that from now on, all consultations should be teleconsultations unless theres a compelling clinical reason not to.

While Covid-19 has catalysed the shift towards telemedicine, it is not the cause. The virtualisation of healthcare has been on the cards for some time, and a small but non-negligible group of NHS patients were already receiving care through e-consulting apps such as Livi and Babylon. But the scale of the change is significant and unexpected, with GPs reporting that a transition that they had imagined would take years had in effect happened within just a few weeks.

Doctors and patients groups are not convinced. Martin Marshall, head of the Royal College of General Practitioners, told the BBC that remote consultations, whether by telephone or video, wont be suitable for everyone, while Mencap have warned that the proposals could be disastrous for those with learning disabilities. And yet the government persists.

Hancocks enthusiasm for telemedicine makes a lot of sense when one considers his longstanding tech-solutionist streak. In 2018 he infamously launched his own app, simply titled Matt Hancock MP. As Wired reported at the time, it collected reams of user data including photos, videos, contact information, and check-ins. Big Brother Watch said it steals data, and called it a fascinating comedy of errors.

Of course, the Matt App is just the ego-massaging tip of the tech-solutionist iceberg. As Sean McDonald has argued, we are in the era of technology theatre, in which governments launch tech-enabled solutions to problems they are fundamentally incapable of solving or unwilling to actually tackle. The NHS Covid-19 app is the perfect example: a project from the health services digital transformation unit that was loudly hailed as the fix for coronavirus, only to be abandoned months later after being found to be almost entirely useless in comparison to human foot-soldiers carrying out contact-tracing. Meanwhile virtual therapy apps are now a staple part of mental healthcare provision, with patients self-referring to online cognitive behavioural therapy companies so they can have counselling delivered through their phone rather than languish for years on NHS waiting lists.

Indeed, it is in areas like mental healthcare that the paucity of tech-solutionist thinking becomes most apparent. Technologies like telemedicine tend only to work for the median case. If you fit within the narrow boundaries of the patient profile for which these services are designed, you will probably benefit from them. But, as is so often the case in healthcare, those with serious or complex health problems will be left out in the cold an experience that is all too familiar to patients with chronic and long-term mental health needs. For this group, as for so many other high-risk patient demographics, face-to-face contact is an absolute necessity for effective ongoing care.

For many, healthcare appointments are the closest thing to a routine, while healthcare professionals are the very fundament of patients personal support networks. Mental healthcare in the UK is already in a parlous state. Care for children and young people with mental illnesses lags dramatically behind much of Europe. In a report in January, the Childrens Commissioner for NHS England found that the NHS spends just 92 per child per year on mental health services, while the UK has just 4.5 psychiatrists per 100,000 young people far below Finlands 36 or Estonias 16.8. Any move away from in-person care will significantly compound the problems already faced by people who have mental health problems.

The government will insist that those who require in-person consultations will still be able to get them, but in reality remote care will almost certainly be foisted upon those who dont want it but who realise that Zoom medicine is suddenly the quickest or only reliable way to access care from an overworked and underfunded health service.

Zoom medicine, disastrous digital transformation projects, and virtual therapy are all part of a trend in which shiny new apps are used to mitigate the symptoms of serious structural problems. Decades of underinvestment have left the health service struggling for survival, and getting GPs on Zoom is not going to solve much. Post-pandemic, telemedicine is seen as the route forward in great part because it will ease the burden on under-resourced GPs. Virtual therapy, meanwhile, is popular not because there is any real evidence to suggest that a bot delivering cognitive behavioural therapy through your smartphone can actually cure your anxiety, but simply because it is all but impossible to get a timely NHS therapy referral in most areas of the UK. These are not solutions they are diversions.

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Why 'Zoom medicine' is not the answer to all our ills - The Guardian