Here is a dense scientific post from the SENS Foundation that might be better read back to front, starting with the research partnership announcement at the end. Some fraction of degenerative aging is caused by an accumulation of various forms of amyloids between cells, probably the best known of which is that involved in Alzheimer’s disease. One goal for the Strategies for Engineered Negligible Senescence (SENS) approach to aging is to establish a general technology platform that can be used to remove any form of amyloid: “In late 2008, we reviewed then-unpublished work by Dr. Mark Pepys, who was working on an ambitious project anticipated to allow for the disaggregation of nearly all disease-associated amyloids. … I am therefore delighted to have the privilege to be given permission [to] make the first public announcement that the Supercentenarian Research Foundation has recently helped to facilitate a collaboration between researchers already working in amyloid diseases, to develop antibodies to cleave aggregated wild-type and mutant transthyretin – the form responsible for senile cardiac amyloidosis (a prevalent, but not exclusive, cardiac amyloidosis in supercentenarians).”

View the Article Under Discussion: http://www.sens.org/node/831

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

The abbreviation KPU stands for pyrroluria, which is a frequently disregarded metabolic disorder that may cause numerous unspecific symptoms. However, it is comparatively easy to treat. In general, KPU (a.k.a. pyrroluria, malvaria, or HPU) is a genetically determined anomaly of hemal production (an aspect of blood formation) which causes increased hemal pyrrole concentrations.

Normally, this substance does not circulate freely in the blood but is bound by bile acid and excreted through the intestines. In KPU-cases, however, crypto pyrrole is increasingly excreted in the urine – unfortunately along with vitamin B6, zinc, and manganese which the body lacks due to this process.
In combination with increased stress (e.g. acute viral rhinopharyngitis, burns, injuries/accidents, intestinal infections, or psychic stress) this causes a wide range of symptoms, such as:
disturbances of memory and sleep, erratic mood swings, depression, hair loss, proneness to infections, and chapped skin. There is also a possible relation to ADHD with children and juveniles. Read more…
Immunice for Immune Support

Could Coffee Reduce the Risk for Diabetes Development?

Lab tests show rats drinking coffee (black) had lower blood sugar levels than rats drinking water.

Coffee drinking is rarely associated as being a boon for someone’s health.  It’s derided for being too high in caffeine, disparaged as being a cause for tooth staining, and pilloried for being a high calorie diet buster.

While the negative health claims of coffee have elements of truth, the anti-coffee crusaders conveniently ignore the benefits of coffee, such as its ability to reduce a person’s risk of liver cancer and alcohol-related liver disease.

But there’s another reason to grab your cup o’ Joe before leaving for work tomorrow:  It may reduce your risk for diabetes.

With the recent health concerns of former Poison front man Bret Michaels, diabetes has been in the news headlines quite a bit lately.  Michaels suffers from type I diabetes and has become the diabetic community’s front man in helping garner attention to a condition that affects hundreds of millions of people worldwide.  Michaels recently appeared on Donald Trump’s “Celebrity Apprentice,” earning hundreds of thousands of dollars for his charity, the American Diabetes Association, in the process.

The hope is that that money will go a long way in helping discover a cure for a disease affects 23.6 million people in the United States alone, as diabetics cope with their disease day after day through insulin therapy, diet alterations and various other treatments.

No one is immune from getting diabetes, and while type I diabetes is usually acquired at birth, type II diabetes—or adult onset diabetes—can occur at any time in life.

But researchers think that people may be able to reduce their risk for type II diabetes by drinking coffee.

Dr. Fumihiko Horio found this link after feeding a group of laboratory rats either water or coffee.  Through blood testing, they found that the rats fed coffee showed an improvement in their sensitivity to insulin and had lower blood sugar levels compared to the water-drinking rats.  Researchers believe coffee’s prevention qualities is due to its high caffeine content, calling caffeine “one of the most effective anti-diabetic compounds in coffee.”

This latest round of research is in contradistinction to a 2008 study that said coffee tended to increase blood sugar levels among diabetics.  In that study, researchers followed 10 people with type II diabetes to see what, if any, effect high levels of caffeine had on their blood sugar levels.  They found that blood sugar levels increased by an average of eight percent when participants consumed a caffeine pill that contained about the same amount of caffeine as an eight ounce serving of coffee.

Of course the difference between the two studies is that one looked at how coffee prevented diabetes, while the other looked at how coffee affected people who already had diabetes.  Another difference is that one study used coffee, while the other used caffeine pills in place of coffee.

This fact alone suggests that it may be something other than caffeine that has diabetes preventive qualities, especially when past studies reached the same conclusions while using decaffeinated coffee.

More research is in the offing.  In the meantime, don’t beat yourself up over your coffee habit.  So long as you’re consuming coffee black and that you’re consuming no more than a couple cups a day, drinking coffee is a healthy habit to have.

Sources
latimesblogs.latimes.com
sciencedaily.com

Discuss this post in Frank Mangano’s forum!

Via EurekAlert!: “A team of researchers has developed a method to produce cells that kill tumour cells in the lab and prevent tumours forming in mouse models of cancer. … In this research, T cells were transformed into cells similar to another type, Natural Killer (NK) cells, which commonly act against viruses and cancer cells. … We had shown that a gene called Bcl11b was essential for normal development of immune system cells – and of particular interest in the development of T cells. Here we can see the fruits of that work: we show, for the first time, that we can modify the developmental fate of immune system cells to produce a novel type that – if we can see the same effect in humans – could be of enormous value in cancer treatment. … the Bcl11b gene was active only in T cells in the immune system and that its activity was needed at the earliest stages of production of T cells. When the team knocked out the Bcl11b gene, the mice produced no T cells. … Remarkably, the mice lacking the Bcl11b gene produced a new type of immune system cell – the Induced T to Natural Killer cells. This is the first time we have seen these cells … Even more important, we can see that these reprogrammed killer cells can attack cancer cells, whether in test tubes or in mouse models. … The ITNK cells killed melanoma and lymphoma cells in experiment in test tubes and were much more efficient than unmodified Natural Killer cells in the mouse and in human.”

View the Article Under Discussion: http://www.eurekalert.org/pub_releases/2010-06/wtsi-mck061010.php

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Kiwifruit, a world favorite, is now being seen as one of the leading “super foods” around because of myriad of health benefits, including its prebiotic potential and anti-cancer potential.

In a recently published Journal of Functional Foods, researchers from the NZ Institute of Plant and Food Research claim that pectin that has been derived from kiwifruit may help improve the levels of good bacteria in the digestive tract.

The humble pectin… was actually a health superstar!

The same pectins (the researchers found a total of six varieties of pectin in the species Actinidia deliciosa) the study says, may also help protect the good bacteria as they flourish in the digestive tract.  A growing body of studies suggest that the once humble pectin (usually used as a gelling agent for fruit jams and as material for encapsulating supplements and drugs) can provide the following benefits:

• Better digestion with pectin’s natural fiber content
• Prebiotics
• Increased heart health with its capacity to lower LDL (low density lipoproteins) or “bad cholesterol”

Compared to inulin fiber, the pectins from kiwifruit showed an enhanced effect on the good bacterias Lactobacillus rhamnosus and Bifidobacterium bifidum. The pectins also helped the body fend off bacterial invasions by lessening the adhesion of bad bacteria like Salmonella typhimurium.

Prebiotics?

The majority of health-inclined individuals around the world know of prebiotics. But how about prebiotics? What do they do?

Probiotics are compounds that encourage the growth and flourishing of good bacteria or essential bacteria in the digestive tract.  They directly contribute to the growth of the organisms in the intestinal flora.

Prebiotics on the other hand, protect the bacterial growth in the intestinal flora.  Since prebiotics are non-digestible substances they can also help carry away waste from the intestines.  Prebiotics are also important because they prolong the life of good bacteria and  they also keep the bacteria healthy.

Other benefits of prebiotics include:

1. May help ease the symptoms of diarrhea caused by taking antibiotics
2. Also helps people suffering from traveler’s diarrhea.
3. Helps reduce the pain and inflammation associated with gastroenteritis.
4. Helps normalize and regulate bowel function.
5. May help improve colitis
6. Can help reduce the incidence of irritable bowel problems.
7. Helps the body absorb calcium
8. Can help strengthen the immune system

Natural sources of prebiotics include:

• Whole grain products
• Leguminous foods
• Onions
• Fresh honey
• Fresh and cooked greens
• Garlic
• Yogurt, milk and other dairy products
• Different types of berries
• Bananas
• Apple cider vinegar (raw, not cooked)
• Jerusalem artichokes
• Other grains (gluten-free)

Amazing benefits of kiwifruit

Does kiwifruit offer other benefits other than prebiotics? Yes! Here are some of the main benefits of getting your healthy dose of kiwifruit everyday:

1. Kiwifruit is rich in vitamins and minerals, including ascorbic acid (vitamin C – one kiwifruit has more vitamin C than a regular orange), beta carotene and potassium. Potassium is brain food that increases one’s alertness and also improves one’s memory.

2. According to research performed in Italy, kiwifruit can also help improve the health of the respiratory tract. Seven portions of the fruit every week can yield respiratory benefits (respondents, children aged six to seven, showed less wheezing and shortness of breath compared to other respondents who received little or no kiwifruit throughout the testing period)

3. Kiwifruit  can also help ward off the effects of age-related macular degeneration.

4. Kiwifruit is a potent source of natural antioxidants, which can help reduce the incidence of certain types of cancer, heart disease and can also improve one’s vision.

5. Kiwifruit is a natural source of soluble fiber, which improves the digestive function and also helps transport human waste more efficiently.

6. Kiwifruit may be helpful in reducing harmful mutations or changes to one’s DNA. This is important in keeping your DNA pristine for the next generation (your children, who will be receiving your DNA – and all that comes with it, including risks to certain types of diseases, etc.)

7. Kiwifruit, because of its high soluble fiber content, can help individuals with insulin-dependent diabetes (or type-2 diabetes) and people with high cholesterol. Natural fiber has been known to control blood glucose levels and bad cholesterol levels.

8. Also due to its high fiber content, kiwifruit may also help prevent deadly colon cancer.

9. Kiwifruit is a natural source of the nutrient inositol. Recent studies show that inositol is very beneficial as a supportive treatment for depression.

10. It contains the compound arginine, which is capable of dilating or opening up constricted blood vessels.  As such, it is not only good for people with hypertension but is also very beneficial for males suffering from impotence or erectile dysfunction. Arginine has been long used for the treatment of impotence in males.

11. In China, a study made use of kiwifruit to see whether Chinese athletes can last longer during the rigorous physical exertion during training.  With the addition of five percent carbohydrates to kiwi juice, the athletes were able to last longer – their blood glucose levels remained stable after taking the kiwi juice.

12. Amazingly, this small fruit also has a high percentage of the natural brain chemical serotonin. This compound has a relaxing effect when utilized by the body.

Kiwifruit is a type of fruit that provides the best ratio of calories to fiber & essential nutrients.

Sources:
foodnavigator.com
nutrition.about.com
mayoclinic.com
bodyecology.com
kiwi-fruit.info
whfoods.com
calharvest.com
bimuno.com

Discuss this article in Frank Mangano’s forum!

A chemical compound called epigallocatechin gallate showed much promise by killing cancerous cells during a phase 2 clinical study.

According to a study performed by researchers from the Mayo Clinic, the extract of the world-popular green tea has been effective in regulating the growth and proliferation of cancer cells in patients with chronic lymphocytic leukemia (CLL).  The study was classified as a phase two human clinical trial, and the results were very promising indeed.

Epigallocatechin gallate vs. cancer cells

The compound epigallocatechin gallate was shown to have the ability to kill cancer cells in patients with CLL.  The compound prevented the cancer cells from surviving, thereby effectively reducing the total cancer cell count. The first phase of the human clinical trial of epigallocatechin gallate also showed similar, positive results.

What does this all mean?  According to one of the Mayo researchers, Dr. Tait Shanafelt, the two clinical trials show that epigallocatechin gallate showed some promise in stabilizing or normalizing the condition of patients with CLL.  While the compound is not classified as a definitive cure for the condition, it shows promise in slowing down the progress of the medical condition.

Instead of a cure, Mayo clinic researchers state that the compound should be viewed as a cancer preventive rather than cancer cure. And there was a catch: the patients that were subjected to the nutraceutical treatment were patients who had early signs of CLL (not advanced stage CLL).

The study involved thirty-six respondents and resulted in a fifty percent reduction of leukemia cell count at the end of the human clinical trial.  Including the patients from the first clinical trial, the total number of CLL patients involved in the study is forty-two.  A third clinical trial is needed before the Mayo Clinic researchers can make a definitive recommendation regarding the use of epigallocatechin gallate for CLL sufferers.

Other benefits of green tea

Tea is the second most drunk beverage in the world (right next to water). It contains natural antioxidants and caffeine (50% less than regular coffee).  And did I mention that it’s good for you for a lot of reasons?  It’s more than just a cancer preventive.  Here are some more health benefits of drinking green tea:

1. According to a study published by the American Medical Association, 40,000 respondents (from Japan; all of them drank up three cups of green tea per day) showed no evidence of cardiovascular anomalies and coronary heart problems since the study started back in the year 1994.  Not one individual from the 40,000 strong group developed any cancer, too!

2. Drinking green tea reduces the risk of dying from heart disease by twenty six percent (for males).  For women, drinking three to five cups of the precious elixir reduced the risk of dying from heart attacks and other cardiac problems by a staggering thirty-one percent.

3. Having chronic problems with sleep apnea (disturbances during sleep) and poor sleep quality, generally?   Reach for green tea.  US studies found out that chemical compounds in green tea can help prevent cognitive troubles resulting from poor sleep.

4. If you have trouble memorizing for school, don’t drink soda.  Instead, make yourself a nice, warm green tea brew.  There is no reason not to enjoy this beverage as it now comes in many natural flavors, like blueberry, cinnamon, etc.

All you have to do is choose your favorite flavor and use a French press to make an instant cup of tea.  Or you can just buy tea bags and allow the tea to infuse itself into the water for a few minutes.  I recommend this and that’s how I make my green tea.  The longer you keep the teabag in the hot water, the stronger the tea.

You can also add a bit of cinnamon to make the tea more interesting.  Since tea has caffeine, it can also help keep you more alert and awake when working or studying.   Green tea also has theanine, which has been shown to have beneficial effects in that region of the human brain that is responsible for alertness.

5. Suffering from poor immunity against common illnesses like the flu and the common cold?  Green tea is rich in chemical compounds called polyphenols, which can help boost your immune system.  Polyphenols can also help slow down aging by reducing the oxidative stress that the body experiences from free radicals.  Polyphenols are capable of disabling free radicals in the body.

6. Substituting polyphenol-rich beverages like green tea for soda and the like can also reverse the spike in body weight.  Because green tea doesn’t have much sugar, it does not contribute much to your weight (apart from its water content).  If you are having trouble with ‘water weight’, then all you have to do is to sip on the green tea during the day instead of downing a whole cup in one go.  But don’t forget: being well-hydrated is more important.  Also, water helps the body lose weight by helping in better digestion and also by helping the body burn calories more efficiently.

7. According to researchers from the Chinese University of Hong Kong, the antioxidants present in green tea can also penetrate the tissues in the eyes and do a world of good there.  Increased antioxidant activity in any body tissue has always been linked to decreased inflammation and healthier tissues and cells.

8. All kinds of tea come from the same camella plant – and tea always has more than ten times the amount of antioxidant chemicals than regular vegetables and fruits.  So drink up!  Green tea can also help prevent dangerous blood clots from forming in veins and arteries (which can lead to heart attack and stroke).  You also reduce the risk for atherosclerosis when you drink plenty of tea, say Dr. John Weisburger, the US’s pro-tea champion and veteran researcher (who is also, incidentally, already eighty two years old!)

Cancer prevention

In the spirit of global cancer prevention, here are some easy steps that you can prevent different types of cancer.

Prostate Cancer

• In a European study, it was discovered that regular intake of legumes and other vegetables lowered the risk of prostate cancer over the long term.
• Nutrients like vitamin D, isoflavanoids and selenium can help reduce prostate cancer by stopping the chemical processes that can lead to the formation of cancer cells.

Skin Cancer

• Increase your intake of antioxidants prior to sun exposure or take an umbrella with you when going out into the direct heat of the sun for a long period of time!
• Beta-carotene has been linked to reduced risk of developing cancerous skin cells.

Lung Cancer

• Long term tobacco smoke has been linked to lung cancer – so stop the habit before it leads to something much, much worse than just stained teeth.
• Regular exercise produces a protective effect on the body – including the respiratory system. Get enough exercise to strengthen your breathing apparatus.

Sources:
sciencedaily.com
blogs.webmd.com
blogs.webmd.com
webmd.com
webmd.com
webmd.com
webmd.com
webmd.com

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Researchers:  Skip Pre-Workout Meal, Increase Fat Loss

Why you may be better off postponing your meal until after you've exercised.

There are plenty of opinions out there regarding the benefits and detriments of eating immediately prior to working out.  Advocates say that food provides the fuel an athlete needs to perform at his or her best.  But detractors say that pre-workout meals prevent the body from burning off stored fat, thus reducing the benefits exercise has in helping people lose weight.

Both arguments have their validity, which is why you need to consider what your goals are before deciding on whether or not to chow down prior to working out.  If your goal is to maximize performance—to leg out that extra mile, or to bench that extra rep—then eating is the way to go.  Fat and carbohydrates provide the muscles with the fuel they need to perform rigorous tasks.

But if the purpose of your exercise program is to lose weight, you may be better off skipping out on that pre-workout shake.

Now, I know what you’re thinking:  Uh, duh Frank – if you want to lose weight, then of course you have to consume less than you’re burning!  But there’s a plethora of data out there suggesting that skipping meals is a bad way to try and lose weight.  Skipping meals slows down the body’s metabolic rate and it also encourages us to eat more later in the day because we’re feeling famished.  In fact, some studies suggest the best way to lose weight is to eat more.

But researchers from the University of Birmingham say that skipping the pre-workout meal “tricks” the body into tapping into fat stores for fuel.

They discovered this after following 14 people who either ate prior to working out or did not eat prior to working out.  For those that did eat, they waited one hour before mounting their bicycles.  Both groups used bicycling as their modes of exercise for the experiment.

At the end of one week, the researchers found that the pre-workout eaters outperformed those that didn’t eat prior to working out (i.e. they didn’t travel as many miles), but the fasting group wound up burning off more fat.

The study is published in the journal American College of Sports Medicine.

Now, does this mean that everyone should skip out on eating prior to working out?  Of course not.  Many people simply can’t exercise on an empty stomach without feeling dizzy.  If this is the case, then by all means, EAT!

Others are able to eat prior to working out and can lose weight just fine.  In fact they’ve tried fasting before exercising, but it left them feeling listless and lethargic, severely hampering their exercise efforts.

For everyone else, though, skipping your pre-workout meal may lead to big gains—or should I say “losses”—in your weight loss endeavors.

Source:
newsmaxhealth.com

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Via Newswise: “Why all the attention on TOR? TOR (target of rapamycin) is a key nutrient-sensing catalytic enzyme that evolution has conserved among every plant and animal species that has cells containing a nucleus. TOR mediates the connection between nutrients in the environment to the growth and metabolism of the organism. Studies in flies, worms, yeast and mice support the notion that the TOR signaling network also plays a pivotal role in regulating the aging process. When TOR signaling is reduced, either through genetic manipulation or via the use of drugs, the organism presumes there are reduced nutrients in its environment and goes into a ’survival’ mode similar to that seen in dietary restriction, which has been shown to extend lifespan and slow the onset of certain age-related diseases. … it remains to be seen which downstream effectors of TOR are key drivers of longevity and which ones elicit only minor effects. In addition to simply extending lifespan, research on the protective effects of TOR is likely to identify which age-related diseases can be slowed by inhibition of the TOR pathway.”

View the Article Under Discussion: http://www.newswise.com/articles/tor-a-key-mediator-of-the-effects-of-dietary-restriction-and-its-impact-on-aging

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Maria Konovalenko on the study of the often large life span differences between similar species – or rather the lack of such research work in comparison to other fields of life science: “Here’s this quite simple idea: to take two species similar in size and basic biology, but having a substantial difference in longevity, and figure out what’s the reason for this difference. What are the distinctions in the mechanisms of aging and stress resistance? It’s desirable to carry out this work in various species. However, not a lot of people are excited about this simple idea. Even the genome of the famous naked mole rat has not been sequenced yet, although many people believe it’s got ‘negligible’ senescence. For now all that we have is negligible funding of evolutionary-comparative biology of aging. Moreover, previously obtained results are put into cold storage. … And here comes the main question in biogerontology. Why is the research into the fundamental mechanisms of aging so scarcely funded?” Aging and longevity research in general receives very little funding and attention in comparison to its importance to the future of human health. This state of affairs is slowly changing, but not fast enough for my liking.

View the Article Under Discussion: http://maria-konovalenko.typepad.com/blog/2010/06/the-main-question-in-biogerontology.html

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Two-Drug Phase I Trial Shows Promise in Treating Late-Stage Ovarian Cancer, ScienceDaily, June 13, 2010. Excerpt:

“Our hypothesis is that decitabine isn’t just targeting active ovarian cancer cells, but also cancer stem cells that seem to survive the first treatments,” [Kenneth] Nephew said. “By keeping tumor suppression genes from being methylated, carboplatin and other platinum-based treatments for ovarian cancer have a better chance of success in the late stages.”

This news release is about the publication entitled: A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer by Fang Fang, Curt Balch and 9 co-authors, including Kenneth P Nephew and Daniela E Matei, Cancer 2010(Jun [Epub ahead of print].

This paper suggests that the relationship between mitochondrial DNA variants and longevity is complex: “There is substantial evidence that mitochondria are involved in the aging process. Mitochondrial function requires the coordinated expression of hundreds of nuclear genes and a few dozen mitochondrial genes, many of which have been associated with either extended or shortened life span. Impaired mitochondrial function resulting from mtDNA and nuclear DNA variation is likely to contribute to an imbalance in cellular energy homeostasis, increased vulnerability to oxidative stress, and an increased rate of cellular senescence and aging. The complex genetic architecture of mitochondria suggests that there may be an equally complex set of gene interactions (epistases) involving genetic variation in the nuclear and mitochondrial genomes. Results from Drosophila suggest that the effects of mtDNA haplotypes on longevity vary among different nuclear allelic backgrounds, which could account for the inconsistent associations that have been observed between mitochondrial DNA (mtDNA) haplogroups and survival in humans. … We hypothesize that aging and longevity, as complex traits having a significant genetic component, are likely to be controlled by nuclear gene variants interacting with both inherited and somatic mtDNA variability.”

View the Article Under Discussion: http://www.ncbi.nlm.nih.gov/pubmed/20601194

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

From Depressed Metabolism, a look at the folk who are trying to ensure that cryonics patients can preserve their resources as well as the fine structure of their brains: “On the weekend of April 23-25 I attended a meeting of the cryonics Asset Preservation Group held [near] Gloucester, Massachusetts. I will try to give a few brief summaries without going into detail about every presentation. … A central problem for cryonicists wanting revival trusts is that Cryopreserved Persons (CPs) are legally dead and are not ascertainable beneficiaries under trust law. My solution to this problem has been to have cryonics organizations (rather than the legal system) recognize the reanimated CP as the beneficiary. But finding the right cryonics organization to do this is not always easy. … the best presentation at this meeting of the Asset Preservation Group was the one on ‘Personal Revival Trusts’ by Igor Levenberg. I have been working with the thorny problems associated with cryonics reanimation trusts for years and I have never seen such careful and persuasive legal analyses.”

View the Article Under Discussion: http://www.depressedmetabolism.com/2010/06/02/fourth-asset-preservation-group-meeting/

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Researchers are turning up new longevity genes at a fair rate these days, and this latest discovery is illustrative of the methods used – start with what you know, and compare and contrast: “A major challenge in translating the positive effects of dietary restriction (DR) for the improvement of human health is the development of therapeutic mimics. One approach to finding DR mimics is based upon identification of the proximal effectors of DR life span extension. Whole genome profiling of DR in Drosophila shows a large number of changes in gene expression, making it difficult to establish which changes are involved in life span determination as opposed to other unrelated physiological changes. We used comparative whole genome expression profiling to discover genes whose change in expression is shared between DR and two molecular genetic life span extending interventions related to DR, increased dSir2 and decreased Dmp53 activity. We find twenty-one genes shared among the three related life span extending interventions. One of these genes, takeout, thought to be involved in circadian rhythms, feeding behavior and juvenile hormone binding is also increased in four other life span extending conditions: Rpd3, Indy, chico and methuselah. We demonstrate takeout is involved in longevity determination by specifically increasing adult takeout expression and extending life span. These studies demonstrate the power of comparative whole genome transcriptional profiling for identifying specific downstream elements of the DR life span extending pathway.”

View the Article Under Discussion: http://www.ncbi.nlm.nih.gov/pubmed/20519778

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

From Singularity Hub: “In order to work in the human body, an artificial cornea has to meet some rather stringent requirements. First, it has to bond to the human eye around its edge, but stay unclouded by cells in its center. To that end, [researchers] took a widely used opthalmological polymer (found often in intraocular lenses) and adapted it with other special polymers around the edges. Combined with the application of a growth factor protein, the modified edge promoted cell growth around the periphery of the implant and secured it in place using the body’s own cells. The center of the artificial cornea, however, does not promote cell growth and remains clear so that it can be seen through. The artificial cornea also has to move freely with the eyelid and balance moisture on its faces. The polymer [researchers] chose is hydrophobic, allowing tears to lubricate the surface and provide the correct moisture on both of its sides. … The artificial cornea has passed clinical trials and is ready to see expanded use in patients this year.”

View the Article Under Discussion: http://singularityhub.com/2010/06/02/germanys-artificial-cornea-getting-ready-to-restore-sight-to-thousands/

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

This post at Less Wrong makes the case for cryonics as a business that would work well at large scale: “Cryonics scales very well. People who argue from the perspective that cryonics is costly are probably not aware of this fact. Even assuming you needed to come up with the lump sum all at once rather than steadily pay into life insurance, the fact is that most people would be able to afford it if most people wanted it. There are some basic physical reasons why this is the case. … Surface area is where heat gains entry. Thus if you have a huge container holding cryogenic goods (humans in this case) it costs less per unit volume (human) than is the case with a smaller container that is equally well insulated. … liquid nitrogen, the super-cheap coolant used by cryonics facilities around the world, is vastly cheaper (more than a factor of 10) when purchased in huge quantities of several tons. The scaling factors for storage tanks and high-capacity tanker trucks are a big part of the reason for this. … The conclusion I get from this is that there is a very strong self-interested case (as well as the altruistic case) to be made for the promotion of megascale cryonics towards the mainstream, as opposed to small independently run units for a few of us die-hard futurists.”

View the Article Under Discussion: http://lesswrong.com/lw/2f5/cryonics_wants_to_be_big/

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Here is a presentation given by researcher Anders Sandberg for Google’s Tech Talk series: “The idea of creating a faithful, one-to-one computer copy of a human brain has been a popular philosophical thought experiment and science fiction plot for decades. While computational neuroscience and systems biology are currently very far away from this goal, the trends towards large-scale simulation, industrialized neuroinformatics, new forms of microscopy and powerful computing clusters point in this direction and are enabling new forms of simulations of unprecendented scope. In this talk I will discuss current estimates of how close we are to achieving emulated brains, technological requirements, research challenges and some of the possible consequences.” A little while back the Future of Humanity Institute published a roadmap to whole brain emulation. This topic is of interest to supporters of engineered longevity as a part of the very long term goal of incrementally replacing the vulnerable biology of the brain with something more robust and damage-resistant. Such as, for example, clusters of diamondoid nanomachines designed to emulate the functions of neurons.

View the Article Under Discussion: http://www.aleph.se/andart/archives/2010/06/whole_brain_emulation_the_logical_endpoint_of_neuroinformatics.html

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

While we’re on the subject of the importance of the brain to engineered longevity, here is news of an infrastructural advance from EurekAlert!: “The Allen Institute for Brain Science announced today that it has launched the Allen Human Brain Atlas, a publicly available online atlas charting genes at work throughout the human brain. The data provided in this initial data release represent the most extensive and detailed body of information about gene activity in the human brain to date, documenting which genes are expressed, or ‘turned on’ where. In the coming years, the Atlas will be expanded with more data and more sophisticated search, analysis and visualization tools to create a comprehensive resource useful to an increasingly wide range of scientists and research programs worldwide. The Allen Human Brain Atlas, available at http://www.brain-map.org, is a unique multi-modal atlas of the human brain that integrates anatomic and genomic information to create a searchable, three-dimensional map of gene activity in the brain. Data modalities in this resource include magnetic resonance imaging (MRI), diffusion tensor imaging (DTI) and histology – providing information about gross neuroanatomy, pathways of neural connections, and microscopic anatomy, respectively – as well as gene expression data derived from multiple approaches.”

View the Article Under Discussion: http://www.eurekalert.org/pub_releases/2010-05/aifb-aif052410.php

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Accelerated aging conditions may result from individual aspects of “normal” aging run wild and out of control. This means we can potentially learn more about those mechanisms. For example: “a gene shown to play a role in the aging process appears to play a role in the regulation of the differentiation of embryonic stem cells. … researchers identified a protein interaction that controls the silencing of Oct4, a key transcription factor that is critical to ensuring that embryonic stem cells remain pluripotent. The protein, WRNp, is the product of a gene associated with Werner syndrome, an autosomal recessive disorder hallmarked by premature aging. … We showed that the depletion of WRNp blocked the recruitment of Dnmt3b to the Oct4 promoter, and resulted in reduced methylation. The reduced DNA methylation was associated with continued Oct4 expression, which resulted in attenuated differentiation. … These results reveal a novel function of WRNp, and demonstrate that WRNp controls a key step in pluripotent stem cell differentiation. Our data support the emerging hypothesis that attenuated stem cell differentiation is involved in aging. This lack of differentiated cells may contribute to failure to maintain organ or tissue function in the later stages of life.”

View the Article Under Discussion: http://sify.com/news/aging-related-gene-plays-role-in-stem-cell-differentiation-news-international-kgfnOiabcdj.html

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

From Depressed Metabolism: “Some contemporary atheists and secular humanists do not stop at debunking the idea of God but seem to think that making a persuasive case against religion requires them to refute all of its associated ideas as well; including the desire for immortality. Paula Kirby is not the first secular person praising our limited lifespan and glorifying death: ‘For atheists it is the very transience of life that helps to give it its meaning: for it prompts us to live it to the full’ … Kirby does not just repeat the hollow non-empirical cliche that life can only have meaning in the face of death but she also pretends to speak on behalf of all atheists. As can be expected, she cannot imagine an extremely long lifespan to be anything else than unspeakable boredom. When she writes that ‘Susan Ertz got it spot on with her witty remark that millions yearn for immortality who don’t know what to do with themselves on a rainy Sunday afternoon’ one cannot help thinking that she is conveying more information about herself and Susan Ertz than about humans in general. … It is remarkable to what extent the notion of death as not only biological but ontological necessity has permeated Western philosophy – remarkable because the overcoming and mastery of mere natural necessity has otherwise been regarded as the distinction of human existence and endeavor.”

View the Article Under Discussion: http://www.depressedmetabolism.com/2010/05/25/humanist-death-apologetics/

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

The New Scientist on calorie restriction: “Dreams of eternal youth feature in many cultures throughout history, but it was only in the 20th century that research into longevity really began. Much about ageing is still mysterious – we don’t even know the underlying reasons why we journey into old age. There are many lines of enquiry into how to live longer, though, with one of the most intriguing being calorie restriction: in effect, going on a lifelong diet. Calorie restriction dramatically extends not only the lifespan of laboratory animals, but also their ‘healthspan’ – how long they live free of disease. On the assumption that it has the same effect in people, some individuals have already adopted a restricted diet. The latest evidence suggests that while calorie restriction is indeed beneficial for humans, when it comes to lifespan extension, it may not be the whole story. The good news is that we might be able to delay ageing without cutting our food intake. … There’s a definite possibility that if you balance the diet correctly, a longer lifespan can be achieved without full food restriction. … It is unclear why eating less should make animals live longer. While a restricted diet triggers numerous changes at the molecular and genetic levels, only some of these are common across all the species tested. However, there does seem to be a general principle that a dearth of nutrients causes organisms to divert resources away from growth and reproduction and towards basic survival functions. From an evolutionary perspective, these adaptations could help an organism survive famine.”

View the Article Under Discussion: http://www.newscientist.com/article/mg20627621.100-eat-less-live-longer.html?full=true

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/