Public release date: 29-Jun-2012 [ | E-mail | Share ]

Contact: Will Sansom sansom@uthscsa.edu 210-567-2579 University of Texas Health Science Center at San Antonio

SAN ANTONIO, Texas, U.S.A. (June 29, 2012) -- Cognitive skills such as learning and memory diminish with age in everyone, and the drop-off is steepest in Alzheimer's disease. Texas scientists seeking a way to prevent this decline reported exciting results this week with a drug that has Polynesian roots.

The researchers, appointed in the School of Medicine at The University of Texas Health Science Center San Antonio, added rapamycin to the diet of healthy mice throughout the rodents' life span. Rapamycin, a bacterial product first isolated from soil on Easter Island, enhanced learning and memory in young mice and improved these faculties in old mice, the study showed.

"We made the young ones learn, and remember what they learned, better than what is normal," said Veronica Galvan, Ph.D., assistant professor of physiology at the Barshop Institute for Longevity and Aging Studies, part of the UT Health Science Center. "Among the older mice, the ones fed with a diet including rapamycin actually showed an improvement, negating the normal decline that you see in these functions with age."

The drug also lowered anxiety and depressive-like behavior in the mice, Dr. Galvan said. Anxiety and depression are factors that impair human cognitive performance. Lead author Jonathan Halloran conducted scientifically reliable tests to accurately measure these cognitive components in the rodents.

Venturing into the open

Mice are burrowers that prefer tunnels with walls. To observe behavior, Halloran used an elevated maze of tunnels that led to a catwalk. "All of a sudden the mice are in open space," Halloran said. "It's pretty far from the floor for their size, sort of like if a person is hiking and suddenly the trail gets steep. It's pretty far down and not so comfortable."

Mice with less anxiety were more curious to explore the catwalk. "We observed that the mice fed with a diet containing rapamycin spent significantly more time out in the open arms of the catwalk than the animals fed with a regular diet," Halloran said.

The second test measured depressive-like behavior in the rodents. Mice do not like to be held by their tails, which is the way they are moved from cage to cage. Inevitably they struggle to find a way out. "So we can measure how much and how often they struggle as a measure of the motivation they have to get out of an uncomfortable situation," Dr. Galvan said.

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Easter Island drug raises cognition throughout life span

MONTREAL – The hope of early diagnosis for autism took a step forward on Thursday as a new study from the Montreal Neurological Institute and Hospital showed that signs of autism may be detected in the brain of infants as young as 6 months old.

The finding, which was published in the American Journal of Psychiatry, could lead to early intervention for children with autism.

Using specialized screening, the study found significant differences in the brain development of infants at high risk for autism starting as early as 6 months.

And the study illustrates how an emerging area of brain imaging research may lead to a much better understanding of how the brain is wired and connected.

This is not just about autism, it has ramifications across the board, said Alan Evans, a lead researcher on the study from the Neuro who is also director of the Montreal Consortium for Brain Imaging Research. We are standing on the threshold of a whole new approach to brain science.

After hearing about the human genome all these years, we now have the connectome. Evans says this is the next phase in neuroscience, that it offers a more complex and rewarding characterization of the brain.

Developing these new technologies offer us a noninvasive window into normal and abnormal brain development which was basically impossible 10 years ago, he said in an interview.

The study used a special type of MRI scan, known as diffusion tensor imaging, which allows for more sophisticated analysis and imaging. It showed abnormal brain development may be detected before the appearance of autism symptoms in an infants first year of life. Autism is typically diagnosed around the age of 2 or 3 years when symptoms appear, such as problems with communication, social interaction and behaviour.

But research shows that symptoms can improve with early intervention so early diagnosis is key.

Evans doesnt foresee this type of scanning to be used on every infant, as it would be very costly. But he does believe if the research is reproduced these types of scans will one day be routine for siblings of children with autism, who have about a 15-per-cent likelihood of developing the disorder.

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Autism can be detected in the brain of infants as young as 6 months old.

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AMSTERDAM, June 21, 2012 /PRNewswire/ —

uniQure, a leader in the field of human gene therapy, announced today the signing of a collaborative agreement with two leading neurology experts to develop further a gene therapy incorporating uniQure’s GDNF (glial cell derived neurotrophic factor) gene for the treatment of Parkinson’s disease.

Professor Krystof Bankiewicz at the University of California, San Francisco (UCSF), a world expert in GDNF gene therapy, and Professor Howard Federoff of Georgetown University, a preeminent physician-neuroscientist, have developed a product approved to start clinical trials in the U.S. using uniQure’s GDNF gene incorporated into an adeno-associated virus-2 (AAV-2) delivery vector. The GDNF gene contains the information to produce a protein necessary for the development and survival of nerve cells. The positive effect of GDNF on nerve cells has already been demonstrated in early research by uniQure in collaboration with the University of Lund, Sweden.

UCSF entered into a collaboration with Dr. Russell Lonser, neurosurgeon and Chief of the Neurosurgical Branch of the NINDS, a division of the National Institutes of Health, to commence a Phase I study of the gene therapy in patients with Parkinson’s disease. Patient enrollment is expected to begin mid-2012. Collaborating on the study will be Drs. Krystof Bankiewicz of UCSF, Howard Federoff of Georgetown University and NINDS co-investigator neurologists Drs. Mark Hallett and Walter Koroshetz.

“This agreement provides uniQure with access to the data from a Parkinson’s disease GDNF clinical study conducted by two of the world’s leading medical researchers in the field. If successful, we intend to manufacture the vector construct ourselves and with a partner progress the product into advanced clinical studies,” said Jrn Aldag, CEO of uniQure. “GDNF has been shown to be involved in several other CNS disorders so if we reach the proof of concept stage in Parkinson’s, we can potentially expand product development quickly and efficiently into clinical trials for other indications, such as Huntington’s and Multiple System Atrophy (MSA).”

“The development of AAV2-GDNF, sponsored by both NIH and by Parkinson’s foundations, has taken us 10 years to complete. We are very pleased that a path for clinical development of AAV2-GDNF as a possible treatment for PD is now in place,” said Dr. Krystof Bankiewicz, UCSF Principal Investigator.

Under the terms of uniQure’s agreement with UCSF, uniQure holds the exclusive commercial rights to all UCSF preclinical data and to IND enabling Phase I clinical data provided to UCSF by NINDS. In the event that the Phase 1 study shows proof of concept, uniQure will use its proprietary manufacturing system for future production of the AAV construct and take responsibility for future development of the gene therapy product. uniQure holds the exclusive license to the GDNF gene from Amgen.

About uniQure

uniQure is a world leader in the development of human gene based therapies. uniQure has a product pipeline of gene therapy products in development for hemophilia B, acute intermittent porphyria, Parkinson’s disease and SanfilippoB. Using adeno-associated viral (AAV) derived vectors as the delivery vehicle of choice for therapeutic genes, the company has been able to design and validate probably the world’s first stable and scalable AAV manufacturing platform. This proprietary platform can be applied to a large number of rare (orphan) diseases caused by one faulty gene and allows uniQure to pursue its strategy of focusing on this sector of the industry. Further information can be found at http://www.uniqure.com.

Certain statements in this press release are “forward-looking statements” including those that refer to management’s plans and expectations for future operations, prospects and financial condition. Words such as “strategy,” “expects,” “plans,” “anticipates,” “believes,” “will,” “continues,” “estimates,” “intends,” “projects,” “goals,” “targets” and other words of similar meaning are intended to identify such forward-looking statements. Such statements are based on the current expectations of the management of uniQure only. Undue reliance should not be placed on these statements because, by their nature, they are subject to known and unknown risks and can be affected by factors that are beyond the control of uniQure. Actual results could differ materially from current expectations due to a number of factors and uncertainties affecting uniQure’s business. uniQure expressly disclaims any intent or obligation to update any forward-looking statements herein except as required by law.

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WASHINGTON–(BUSINESS WIRE)–

Patients with Parkinsons disease who undergo deep brain stimulation (DBS)a treatment in which a pacemaker-like device sends pulses to electrodes implanted in the braincan expect stable improvement in muscle symptoms for at least three years, according to a Department of Veterans Affairs study appearing in the most recent issue of the journal Neurology.

VA was proud to partner with the National Institutes of Health in this research, said Secretary of Veterans Affairs Eric K. Shinseki. Our research on Parkinsons helps ensure we continue to provide the best care possible for Veterans with this debilitating disease.

VA cares for some 40,000 Veterans with the condition.

In DBS, surgeons implant electrodes in the brain and run thin wires under the skin to a pacemaker-like device placed at one of two locations in the brain. Electrical pulses from the battery-operated device jam the brain signals that cause muscle-related symptoms. Thousands of Americans have seen successful results from the procedure since it was first introduced in the late 1990s. But questions have remained about which stimulation site in the brain yields better outcomes, and over how many years the gains persist.

Initial results from the study appeared in 2009 in the Journal of the American Medical Association. Based on the six-month outcomes of 255 patients, the researchers concluded that DBS is riskier than carefully managed drug therapybecause of the possibility of surgery complicationsbut may hold significant benefits for those with Parkinsons who no longer respond well to medication alone.

A follow-up report in the New England Journal of Medicine in 2010, using data from 24 months of follow-up, showed that similar results could be obtained from either of the two brain sites targeted in DBS.

The new report is based on 36 months of follow-up on 159 patients from the original group. It extends the previous findings: DBS produced marked improvements in motor (movement-related) function. The gains lasted over three years and did not differ by brain site.

Patients, on average, gained four to five hours a day free of troubling motor symptoms such as shaking, slowed movement, or stiffness. The effects were greatest at six months and leveled off slightly by three years.

According to VA Chief Research and Development Officer Joel Kupersmith, MD, This rigorously conducted clinical trial offers valuable guidance for doctors and patients in VA and throughout the world. As our Veteran population and the general U.S. population grow older, this research and future studies on Parkinsons will play an important role in helping us optimize care.

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Public release date: 25-Jun-2012 [ | E-mail | Share ]

Contact: Thomas Keppeler tom.keppeler@tufts.edu 508-839-7910 Tufts University, Health Sciences Campus

Quality of life has become accepted as an important predictor of survival among human patients with heart failure. Now veterinarians at the Cummings School of Veterinary Medicine at Tufts University have developed two surveys that may prove to be similarly useful in evaluating the quality of life for dogs and cats with heart disease.

Known as "FETCH" (Functional Evaluation of Cardiac Health) and "CATCH" (Cats' Assessment Tool for Cardiac Health), the surveys ask owners to rank aspects of their dog's or cat's health on a scale of 0 to 5. Veterinarians are then able to assess the animal's perceived quality of life, which may inform decisions about treatment, nutrition or even euthanasia.

Researchers found that the FETCH and CATCH scores correlated well to the International Small Animal Cardiac Health Council (ISACHC) classification for disease severity.

Results of the CATCH evaluation were published in the May 15 edition of the Journal of the American Veterinary Medical Association, building on the earlier publication of the FETCH study.

"Studies have indicated that pet owners value quality of life much more than longevity in their animals," said Professor of Clinical Sciences Lisa M. Freeman, board-certified by the American College of Veterinary Nutrition . "We want our dogs and cats to have happy lives, and we believe this tool is a helpful in evaluating whether our pets still do."

The survey tools were developed by Freeman and Professor of Clinical Sciences John E. Rush, board-certified cardiologist and criticalist at the veterinary school's Foster Hospital for Small Animals. Freeman and Rush set out to create and evaluate a tool for pets similar to the Minnesota Living with Heart Failure Questionnaire, one of the most widely used evaluation tools in human cardiology.

The CATCH tool was validated using studies in 75 cats at Tufts' Foster Hospital for Small Animals, the University of Pennsylvania's Medical School and the VCA Animal Care Center of Sonoma County (Rohert Park, Calif.), then tested in 200 cats at the three previous sites, as well as Oregon State University, Massachusetts Veterinary Referral Hospital (Woburn, Mass.) and Angell Animal Medical Center in Boston.

The work on the tools will continue to measure their responsiveness to medical treatment and create a clinical and research tool for clinicians, Freeman said.

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New tools for evaluating quality of life for cats, dogs with heart disease

I didn’t know anything about multiple sclerosis (MS) 6.5 months ago. On Dec. 8, 2011 I got a crash course when my 18-year-old daughter had a severe sudden onset that paralyzed her on her left side, and left her blind in her left eye and unable to speak or swallow.

In hindsight, the headaches she was experiencing two days leading up to the catastrophic onset we thought were due to all the studying she was doing for her ACT test were MS-related. The tingling in her fingers that we thought was over-texting syndrome was most likely the first sign of her MS, and happened two weeks before she collapsed.

She dragged herself into my work and I knew instantly something was terribly wrong. She had been tired that day. She went home from school to nap. She missed her cheerleading training that was so important for her upcoming college tryouts. Her left leg was limp, her eyes pleading for help before she even spoke a word. “Mom, I am so scared. I can’t feel my leg or my arm. It feels like it isn’t attached to my body.” She couldn’t make it back to the car. Lifting my 18-year-old high school senior into the front seat of my SUV, my head was saying maybe it was just a pinched nerve. But my heart was aching with a knowing that it was far more serious than that.

We rushed to the emergency room. Her inability to move any part of her left side was becoming worse by the minute. By 9 p.m., she couldn’t move a finger or a toe, the left side of her face was sagging, and her words were becoming muted. The stroke test was negative. The CT scan warranted an MRI. I was pacing and told the nurse I had a really bad gut feeling. At 10:36 p.m., the ER doctor came into the room that was only separated from the person next to us by a thin cotton curtain. He sat down across from me as I sat bumped right up against the gurney holding Breea’s hand. She was medicated by that time and not conscious. “We have found some abnormalities on her brain. She won’t be leaving the hospital, Ms. Renee. The neurologist is on his way.”

The word “abnormalities” just kept echoing — his mouth was moving but I felt like I was in an episode of Grey’s Anatomy, playing the devastated parent that just got horrific news. But it wasn’t a script. It was really happening. The nurse looked at with the “I am so sorry” look and I wanted to throw up, scream, grab my daughter and squeeze so tight that whatever was in her brain making her this way would somehow be gone. I grabbed my phone and called my best friend, my family, and my boss. Life as we knew it faded away in front of my eyes on a gurney in the ER.

After a battery of tests, including a brutal spinal tap, Dr. Jay Rosenberg delivered the diagnosis while we were in ICU. She had lost her ability to feel her bladder or bowels, she could not swallow or talk, and any sudden movement made her heart rate skyrocket. They had to keep her sedated and given any sort of nutrients via an IV. The diagnosis: Severe sudden onset of tumefactive multiple sclerosis, the rarest form of this mystery disease.

Over the next six months, there would be insurance issues that made getting physical therapy impossible. I became her physical therapist and occupational therapist. We used toys and gadgets, cheap supplies from Target, and anything we could find out in nature. Carving her name in the sand with a stick became a great way to learn how to hold something in her left hand again. A child’s bubble wand became a very handy tool for all sorts of arm exercises, and tiny cones set up as an obstacle course so she could learn to crawl first made therapy everyday more fun than work. We never went home because there were stairs. The MS Society helped us get into a one-story apartment that was perfect for our new lifestyle, and our friends and Breea’s school threw us fundraisers to help us stay afloat since we were getting nowhere with disability or in home support services.

Through it all, Breea kept not only her sense of humor but her drive to succeed, walk again, graduate and go to college just as she had planned before MS. “Feeling sorry for myself won’t heal my lesions. Focusing on my dreams and having a positive attitude will give me the strength I need to live a normal life again.” I love this kid.

On Friday, June 1, 2012, in her purple leg brace with butterflies on it, she walked with the class of 2012 and graduated with a 3.8 GPA. She is attending NAU in the fall, and has chosen nursing as her major. We know more than we ever thought possible about a disease that is such a mystery not only to us but to the medical community as well. We know there is no cure. We know that they are making advances in developing medications and treatments to slow the progression of this autoimmune disease that attacks the myelin in the brain and spinal cord. We know that 2.5 million people around the world have MS and that 200 more cases are reported each week. One of those new cases is Jack Osbourne.

I hope he chooses to use his celebrity to educate others about this disease. Even though his onset seems to be what is more typical in terms of symptoms and severity, probably relapsing-remitting or primary progressive in nature, it doesn’t really matter. Suddenly the world became smaller in a way. Suddenly my daughter, and now Jack Osbourne, is part of the family of people battling MS, the disease that someone told me recently feels like an axe over your head that you never know if or when it will fall.

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Michelle Renee: Multiple Sclerosis: What Jack Osbourne and My Daughter Have in Common

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BOSTON, June 21, 2012 /PRNewswire/ –A new study analyzing patient data from Braintree Rehabilitation Hospital in Braintree, Massachusetts, found that blood pressure fluctuations can worsen symptoms of Parkinson’s disease. Conversely, after treating Parkinson’s disease patients who experienced blood pressure drops when changing from a sitting to standing position, improvements were noted in cognitive function, balance and walking, according to the researchers at Braintree Rehabilitation Hospital.

Information from the study will be presented today at the Movement Disorder Society’s 16th International Congress of Parkinson’s Disease and Movement Disorders in Dublin, Ireland. The corresponding abstract, “Treating Orthostatic Hypotension in Patients with Parkinson’s and Atypical Parkinsonism Improves Function,” will be published as an electronic supplement to The Movement Disorders Journal online edition at http://www.movementdisorders.org.

“This new research sheds light for better Parkinson’s disease treatment, as blood pressure can be affected by the disease and problems often worsen over time,” said Dr. Anna DePold Hohler, Medical Director of the Movement Disorders Program at Braintree Rehabilitation Hospital and Associate Professor of Neurology at Boston University Medical Center, who participated in the study. “The good news for Parkinson’s disease patients is that implementing simple interventions, monitored by a physician, can significantly improve functionality.”

In the United States, 1.5 million people suffer from this complex neurodegenerative disorder. For this population, blood pressure drops may occur due to a decrease in the neurotransmitter norepinepherine and as a result of medications used to treat motor symptoms.

Depending on the patient, treatment strategies might include increasing water or salt intake, use of compression stockings, and slow position changes. Specific medications may also be warranted in patients at risk for fainting.

These findings update previous work conducted at Braintree Rehabilitation Hospital recently published in the International Journal of Neuroscience, 2011.

The Movement Disorders Program at Braintree Rehabilitation Hospital, a world-class rehabilitative care provider, allows patients to have physical, occupational and speech therapy along with medication adjustments, blood pressure adjustments, and deep brain stimulation adjustments as needed. As a result, improvements in patients are significant and a large number of individuals can be optimized to return home.

Braintree Rehabilitation Hospital is located at 250 Pond Street in Braintree, Massachusetts. For more information visit http://www.braintreerehabhospital.com, or call (781) 348-2500.

Media contact: CM Communications Lori Moretti or Meg Fitzgerald mfitzgerald@cmcommunications.com 617-536-3400

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Quality of Life, Daily Living Did Not Improve in Study

By Denise Mann WebMD Health News

Reviewed by Laura J. Martin, MD

June 20, 2012 — For some people with Parkinson’s disease, deep brain stimulation can have immediate and dramatic effects on tremors, rigidity, balance, and other motor symptoms.

Now new research shows that these benefits may last at least three years. The findings appear online in Neurology.

Deep brain stimulation uses a battery-operated device to deliver electrical impulses — similar to a pacemaker for the heart — to areas of the brain that control movement. The impulses are thought to block abnormal signals that cause many of the movement problems (motor symptoms) of Parkinson’s. This procedure is typically reserved for individuals who no longer respond to their Parkinson’s medications or who experience unacceptable side effects from them.

According to the new findings, this treatment helped with motor symptoms such as tremor, but individuals did show gradual declines over time in their quality of life, ability to perform tasks of daily living, and thinking skills.

“This study looked past the immediate ‘wow effect,’” says Michele Tagliati, MD. He wrote an editorial accompanying the new study.

“Now we want to know what we can expect over the next 10 years, and this starts to make it clearer,” says Tagliati, the director of the Movement Disorders Program at Cedars-Sinai Medical Center in Los Angeles.

“The effect on motor function is sustained,” says researcher Frances M. Weaver, PhD. She is the director of the Center for Management of Complex Chronic Care at Edward Hines Jr. VA Hospital in Hines, Ill. But “deep brain stimulation does not have an impact on the other symptoms of the disease, so there will be progression.”

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Device Calms Parkinson's Tremor for 3+ Years

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Dallas, TX (PRWEB) June 22, 2012

Jack Osbourne revealed earlier this week that he has Multiple Sclerosis, reported mtv.com. According to the report, the youngest son of rock icon Ozzy Osbourne and ‘America’s Got Talent’ judge Sharon Osbourne, was diagnosed with MS just weeks after his daughter’s birth in April. And to help spread awareness about the disease, GreenBeanBuddy.com shared basic information about it.

Based on the report, the 26-year old Osbourne was angry and frustrated when he was given the diagnosis. It added that his mother, Sharon Osbourne, shared with Hello magazine how she’s wondering she may have contributed to Jack’s illness.

However, in a separate post from mtv.com, it was said that both Ozzy and Sharon are confident that their son will overcome the said disease. Ozzy even advised his kid to get a second opinion and undergo further testing to be certain, added the report.

Here’s an excerpt of the post Multiple Sclerosis, Basic Facts About the Disease That Caught Jack Osbourne by GreenBeanBuddy.com.

Angry and frustrated those were the reactions of Jack Osbourne when he was diagnosed of Multiple Sclerosis just weeks after his daughter’s birth. However, his parents, rock icon Ozzy Osbourne and America’s Got Talent judge Sharon Osbourne, were confident that the 26-year-old will beat the disease. But what is Multiple Sceloris and how can it be treated?

Multiple Sclerosis or MS is basically an unpredictable autoimmune disease. It attacks the central nervous system by inflaming the brain and the spinal cord and with that it losses the myelin sheath around the nerves. That leads to symptoms as loss of vision, numbness, tingling, excessive fatigue and weakness.

Read more about Jack Osbourned Diagnosed with Multiple Sclerosis at: http://www.greenbeanbuddy.com/2114/multiple-sclerosis-basic-info-disease-caught-jack-osbourne/

As related by entertainment and health news website GreenBeanBuddy.com, Multiple Sclerosis or MS is an incurable autoimmune disease. It added that the cause or causes of it are still unclear and that is one of the reasons why no cure for it has yet been discovered.

Nonetheless, there is now an array of treatments to slow down the disease’s progress, shared the website. And given that Jack Osbourne got the means to get the right doctors and treatments, the site commented that he got a big chance of living a fulfilling despite having the disease.

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Jack Osbourne Discloses His Multiple Sclerosis Diagnosis; GreenBeanBuddy Shares Basic Information About the Disease

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ALMOST a third of dementia diagnoses in Australia are incorrect, a medical expert says.

A federal inquiry into early diagnosis and intervention for dementia has heard that 30 per cent of patients diagnosed with dementia are later found to be suffering from other conditions.

Dr Robert Prouse, from the Royal Australian College of Physicians, says other conditions such as depression can mimic the symptoms of dementia.

“There’s a whole range of things that can present as cognitive decline that need to be tested along the way and that’s where specialists come into it,” Dr Prouse told the inquiry in Sydney on Friday.

“It’s probably common enough to say a third of patients improve, lose their depression and have a new outlook on life.”

“We’ve had a number of people who have had significant cognitive decline,” Dr Prouse said.

“By treating their sleep apnoea and improving nocturnal oxygenation, they’ve come back to normal.”

The inquiry by the House of Representatives Health and Ageing Committee is examining whether dementia should be made a National Health Priority Area due to its growing prevalence in communities.

Dementia in Australia is expected to triple by 2050.

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Jude wants to know the latest on MS or Multiple sclerosis. This is very timely since just this week, Jack Osborne was diagnosed with MS at age 26.

The interesting part about someone famous with a medical condition is the fact that it raises awareness of the condition. MS is one of those conditions that you think is not very common in the very young, but in reality, MS affects all age levels. The interesting abnormality with Jack Osborne having the diagnosis is the fact that he is a male. Usually, females are affected more than males.

Multiple sclerosis is the damage of nerve cells by an unknown trigger. The immune system targets the cells as potential “invaders”, and attempts to destroy them. Since the body is attacking itself, this is considered an autoimmune problem. MS can be literally called “multiple scars”. Since the nerves are like wires in electricity, if you damage the wires, the current does not get to the end organ appropriately. There are also some symptoms or short circuits noticed. The most common symptom is numbness, tingling, or loss of sensation or strength.

Statistics of MS:

400,000 Americans have MS

2.5 million worldwide – not a mandatory report, so it is thought to be under reported.

Women are 2x more affected than men

Caucasians are affected more than any other ethnic group, but all groups can be affected MS is not a fatal disease, but it is chronic MS is not a contagious disease

No age is spared – youngest to be diagnosed 2 years-old, oldest 75 years-old

No cure – yet

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Public release date: 21-Jun-2012 [ | E-mail | Share ]

Contact: Melissa Ashman mashman@brain.ubc.ca 604-827-3396 University of British Columbia

Multiple sclerosis (MS) patients appear to have a lower cancer risk, according to a new study led by researchers at the University of British Columbia and Vancouver Coastal Health.

The study, published in the current issue of the journal Brain, is the first to investigate overall cancer risk in MS patients in North America.

“Because the immune system plays important roles in both cancer and MS, we wanted to know whether the risk of cancer is different for people with MS,” says Elaine Kingwell, the study’s lead author and a postdoctoral fellow in the UBC Faculty of Medicine and Brain Research Centre at UBC and VCH Research Institute. “Not only did MS patients have a lower overall cancer risk, the risk for colorectal cancer in particular was significantly lower.”

The researchers compared the diagnoses of cancer in MS patients in British Columbia with those of the general population. While they found that MS patients have a lower risk in general for cancer and in particular for colorectal cancer they found that the risks for brain cancer and bladder cancer were slightly elevated (albeit not significantly). In patients with relapsing-onset MS, the risk for non-melanoma skin cancer was significantly greater.

Further studies will be needed to understand the reasons for this reduced overall cancer risk.

An unexpected finding was that for those who did develop cancer, tumour size tended to be larger at time of diagnosis. More work is needed to determine why some tumours might be caught later in people with MS.

“Because the symptoms of MS can be broad and include feelings of fatigue, it’s possible the symptoms of cancer are being masked or overlooked,” says Helen Tremlett, the study’s senior author and an associate professor in the UBC Faculty of Medicine. She adds that, regardless of the findings, MS patients and their physicians are encouraged to follow cancer screening guidelines. Her team is planning a follow up study to determine whether death rates due to cancer are altered in MS patients.

###

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Multiple sclerosis patients have lower risk of cancer: UBC-VCH research

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(VIVAnews/Robbi)

VIVAnews Four out of five children of a retired police officer First Sub-Lieutenant (Ret.) Sahirun and Warsini are paralyzed. It all began in 2005 when the father who had no money was forced to take his family to an old pig den.

Suddenly, his children become paralyzed, one by one. They are Musiaroh (36), Amin Muntoha (35), Musinah (27), and Riyatin (25). Meanwhile Kiswanto (30) who lived with other people was not affected.

Based on previous medical examination, the disability was caused by a genetic disorder.

A neurosurgeon of Margono Sukaryo Hospital in Purwokerto, dr Untung Gunarso, said the four people had been admitted to the hospital.

Based on the diagnosis, they suffer from muscle atrophy, he told VIVAnews, on Thursday.

The four siblings were then taken to Kariadi Hospital in Semarang. They even had their blood samples sent to Europe to be studied in a laboratory. It is concluded that the four siblings have a genetic disorder or Friedreich’s ataxia syndrome.

This type of illness usually attacks 15-year-old adolescents, and may worsen when the patient reaches the age of 22.

So, in relation with the allegation of a virus attack caused by their former residence with their parents in an old pig den, its still uncertain yet, he said.

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Four Children of Retired Policeman Paralyzed

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[Day 5 of Robert Wenzel's 30-day reading list that will lead you to become a knowledgeable libertarian, this Mises Daily was originally published August 21, 2009.]

In 1918, the Soviet Union became the first country to promise universal "cradle-to-grave" healthcare coverage, to be accomplished through the complete socialization of medicine. The "right to health" became a "constitutional right" of Soviet citizens.

The proclaimed advantages of this system were that it would "reduce costs" and eliminate the "waste" that stemmed from "unnecessary duplication and parallelism" i.e., competition.

These goals were similar to the ones declared by Mr. Obama and Ms. Pelosi attractive and humane goals of universal coverage and low costs. What's not to like?

The system had many decades to work, but widespread apathy and low quality of work paralyzed the healthcare system. In the depths of the socialist experiment, healthcare institutions in Russia were at least a hundred years behind the average US level. Moreover, the filth, odors, cats roaming the halls, drunken medical personnel, and absence of soap and cleaning supplies added to an overall impression of hopelessness and frustration that paralyzed the system. According to official Russian estimates, 78 percent of all AIDS victims in Russia contracted the virus through dirty needles or HIV-tainted blood in the state-run hospitals.

Irresponsibility, expressed by the popular Russian saying "They pretend they are paying us and we pretend we are working," resulted in appalling quality of service, widespread corruption, and extensive loss of life. My friend, a famous neurosurgeon in today's Russia, received a monthly salary of 150 rubles one-third of the average bus driver's salary.

In order to receive minimal attention by doctors and nursing personnel, patients had to pay bribes. I even witnessed a case of a "nonpaying" patient who died trying to reach a lavatory at the end of the long corridor after brain surgery. Anesthesia was usually "not available" for abortions or minor ear, nose, throat, and skin surgeries. This was used as a means of extortion by unscrupulous medical bureaucrats.

"Slavery certainly 'reduced costs' of labor, 'eliminated the waste' of bargaining for wages, and avoided 'unnecessary duplication and parallelism'."

To improve the statistics concerning the numbers of people dying within the system, patients were routinely shoved out the door before taking their last breath.

Being a People's Deputy in the Moscow region from 1987 to 1989, I received many complaints about criminal negligence, bribes taken by medical apparatchiks, drunken ambulance crews, and food poisoning in hospitals and child-care facilities. I recall the case of a 14-year-old girl from my district who died of acute nephritis in a Moscow hospital. She died because a doctor decided that it was better to save "precious" X-ray film (imported by the Soviets for hard currency) instead of double-checking his diagnosis. These X-rays would have disproven his diagnosis of neuropathic pain.

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What Soviet Medicine Teaches Us

SAN FRANCISCO–(BUSINESS WIRE)–

The very nature of a health care professional is already rendered heroic by the community and patients they serve. The San Francisco Business Times wants to make sure the true heroes in the health care profession dont go unnoticed by publishing their annual list of finalists for their Health Care Heroes Awards. This year, physical therapist, Cindy Gibson-Horn, creator of BalanceWear, has been named to the list. Gibson-Horns discovery nearly a decade ago of Balance-Based Torso-Weighting (BBTW) led to the creation of BalanceWear, a semi-custom made orthotic that has helped dramatically improve stability in patients with MS, Parkinsons disease, stroke, TBI, ataxia and other Sensory Based Motor Disorders (SBMD).

Steve Cookston, CEO of Motion Therapeutics, the company that manufactures and markets BalanceWear, has worked with Gibson-Horn the past several years to bring the BalanceWear product line to fruition and credits Gibson-Horns passion for her patients well-being as a major reason for the products success.

Cindy is committed to giving her patients freedom, says Cookston. Balance and mobility are keys to independence as well as being vital to rehabilitation. Having worked with many medical devices and products, BalanceWear is the most inspiring, often taking a patient from being dependent on others to complete liberation.

If someone had told me they were going all the way to California from the east coast to see if a vest would help with balance, I probably would have told them they were crazy. But I saw and now I believe! BalanceWear has been a miracle for my mother and our family. Even though she will be 79 on June 25, we have our mother back the way she wants to be and the way we want her to be, said Kevin Eck.

I have MS and have used the BalanceWear vest for the last four months. It has made a tremendous difference in my life as I can now walk without my cane. I am walking more than I had using my cane and so am increasing strength and decreasing my possibility for Osteoporosis. I am going places I havent in a long time and my mood has improved, said Lisa Cohen.

I have used BalanceWear on at least ten individuals with ages ranging from 2 years old to 32 years old. I find that there are immediate positive changes in my patients ability to improve static and dynamic balance, improve functional mobility, such as walking up and down stairs without holding onto the railing; the ability to take independent steps without use of an assistive device or help; the ability to run in a straight line with reciprocal arm swing; and the ability to go from sit to stand without losing their balance, said Elaine Westlake, MA, PT.

Physical Therapist, Cynthia Gibson-Horn, discovered that strategically placed small amounts of weight could counter-balance directional losses and dramatically improve stability in patients with MS, Parkinsons disease, stroke, TBI, ataxia and other Sensory Based Motor Disorders (SBMD) during clinical applications. This discovery led to the development of the patented BBTW method and BalanceWear, which has now helped hundreds of patients.

Recently, a National Institutes of Health Recovery Grant of just under $400,000 was awarded to Samuel Merritt University (SMU) Physical Therapy Professor Dr. Gail Widener, PT, and Dr. Diane Allen at San Francisco State University to continue research into Balance-Based Torso Weighting (BBTW) and its effects on Multiple Sclerosis (MS) mobility challenges. The first phase of the study validates previous research funded by the National MS Society. The research is currently in its second phase and has led to documented evidence of the efficacy of prior clinical observations.

The San Francisco Business Times award brings attention to the health care profession and the numerous advances for patients that are suffering with debilitating illnesses, says Gibson-Horn. I am so honored to be among the finalists, but I see heroes in my patients who wake up every day with balance and walking challenges that I can only witness. Perhaps it sounds clich, but this honor is shared between me and my patients. Were in the healing process together.

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BalanceWear® Creator, Cindy Gibson-Horn, Named Finalist in San Francisco Business Times Health Care Heroes Awards

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(CBS News) New York City Mayor Michael Bloomberg shrugged off criticism of his controversial public health initiatives, saying that "if government's purpose isn't to improve the health and longevity of its citizens, I don't know what its purpose is."

Bloomberg most recently put forth a plan to ban the sale of sugary drinks larger than 16 ounces from the city's eateries, street carts and stadiums.

The proposal has been sharply criticized, in some cases by beverage and fast food companies as a case of government overreach.

He's also been criticized for previous efforts to, among other things, ban smoking in public places and the use of trans-fats in restaurant foods. Some have gone so far as to mock has as being like a "nanny."

But on "CBS This Morning," Bloomberg fired back, saying, "We're not here to tell anybody what to do. But we certainly have an obligation to tell them what's the best science and best medicine says is in their interest.

Bloomberg group dangles $9M for ways to aid city life

"If you want to smoke, I think it's pretty ridiculous, you shouldn't. But I don't think we should take away your right to smoke."

Bloomberg pointed out that life expectancy iin New York City exceeds the national average by three years, noting that all the progress has come since he took office a decade ago.

He brushed aside all the attention the proposed ban has gotten, saying, "That's just because it's the story of the week. That'll get blended into lots of other things."

Bloomberg applauded the efforts of some companies that "really understand," such as Coca-Cola, Pepsi and Disney.

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Bloomberg fires back at "nanny" critics: It's part of government's role

Editor’s Choice Main Category: Parkinson’s Disease Article Date: 16 Jun 2012 – 0:00 PDT

Current ratings for: ‘Parkinson’s Disease – Smelling Test For Early Detection’

5 (1 votes)

Researchers have now discovered that the sense of smell provides valuable indications. Hyposmia, i.e. losing the ability to smell for no known cause could be a markers for the non-motor signs of Parkinson’s disease. Dr Ulrich Liebetrau, chief physician for Parkinson’s consultations at the Neurological Department of Kliniken der Stadt Kln, declared at the 22nd Meeting of the European Neurological Society (ENS) in Prague: “Smelling tests in doctors’ offices are suitable for detecting hyposmia but so too are tests conducted in public places such as pedestrian zones.”

Parkinson’s is a very common neurological slowly progressive disease that usually affects individuals aged between 50 and 60 years. In Germany alone there are about 300,000 people diagnosed with Parkinson’s. Scientists still remain uncertain for the reasons of cell death occurring in the substantia nigra in the basal ganglia of the brain of Parkinson’s patients, but suspect that genetic factors may be involved. The cell death causes a shortage of dopamine, a neurotransmitter, which leads to loss of control over voluntary and involuntary movements. German neurologists from Cologne have now tested a new early detection method for subtle signs of Parkinson’s which focuses on the partial loss of the sense of smell, which they based on previous studies that demonstrated that one in ten people with hyposmia develop Parkinson’s in later years.

Dr Liebetrau explained: “Our objective was to reach as many people with hyposmia as we possibly could.”

The team used an unusual method for their trial. They performed a public smelling test on a Saturday in a banqueting hall in Cologne’s pedestrian district that is well known. Liebetrau described the requirements the venue needed to fulfill, saying:

They asked 187 participants to smell vanilla, lemon, cloves and lavender to smell. Overall, 46 participants were identified as having hyposmia, who were all offered a follow-up at the City of Cologne Clinics (Kliniken der Stadt Kln). Dr Liebetrau explained: “The test was to be followed up by a professional examination done by neurologists and ENT specialists at a separate time and place. After all, hyposmia can be a sign of any number of diseases.”

The result revealed that three of the 46 individuals with hyposmia were diagnosed with Parkinson’s, even though they had no former knowledge prior to the test that they were affected by the disease.

One of the key advantages of low-threshold tests is that diseases that would otherwise go undetected are identified early, which also prevents these diseases from becoming chronic. Early diagnosis is advantageous, even if they involve severe neurological disorders like Parkinson’s.

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Parkinson's Disease – Smelling Test For Early Detection

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DETROIT, June 18, 2012 /PRNewswire-iReach/ --If there's one message viewers and guests alike will take away from the cutting-edge, conversational new health TV talk show, Ask Dr. Nandi, it's that "you have to be an advocate for your own care."

(Photo: http://photos.prnewswire.com/prnh/20120618/CG25914)

That's the premise behind Ask Dr. Nandi, a new talk show airing on Wednesdays on WADL. The first episodes focusing on topics like yoga, Celiac disease and childhood obesity and featuring the Detroit-based physician, Dr. Partha Nandi, aired in California to wide acclaim. Now, the show comes to his hometown.

"I want patients to know the truth about their care," says Nandi. "If you feel you're not being heard, please get another opinion. Be an advocate for your own care; this includes fighting for appropriate care from your insurance plan."

Every episode of Ask Dr. Nandi focuses on a single health problem. "We talk about a problem in detail for people so they understand it and know how to resolve it," says Nandi. "This show offers real solutions. We like to say, 'we'll go there' and we will! We are not afraid to tell the truth."

Guests include Julie Silver of Acupuncture Healthcare Associates of Michigan; fitness guru Nikki Fayne; dermatologist Dr. Wendy Sadoff; cardiologist Dr. Joel Kahn; and patient Cheryl Grossman, among other guests.

The show airs on WADL, Detroit's Channel 38, on Wednesdays at 11 a.m. Episodes will air in succession throughout the summer.

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A New and Honest Detroit Doctor Show on WADL

ScienceDaily (June 12, 2012) Coaches, owners and fantasy-league traders take note: Sleep researcher W. Christopher Winter, MD, has uncovered a link between a pro athlete's longevity and the degree of sleepiness experienced in the daytime.

Winter is presenting two studies June 12 at SLEEP 2012 that associate the career spans of baseball and football players with their voluntary answers on a sleepiness questionnaire. The results show that less sleepy football players tended to remain with their drafting NFL teams after college. In addition, attrition rates for sleepier baseball players trended higher than MLB averages.

"A team's ability to accurately judge a prospect or a potential trade in terms of the value they will get for that player is what makes or breaks many professional sport teams," said Winter, principal investigator of the studies and the sleep advisor for Men's Health magazine. "These studies demonstrate that a simple evaluation of sleepiness may be a powerful tool to add to the list of tests athletes already undergo, such as the Wonderlic Cognitive Abilities Test and the 40-yard dash."

The football study looked at 55 randomly selected college players who landed in the NFL, finding that sleepier athletes only had a 38 percent chance of staying with the team that originally drafted them. In comparison, 56 percent of the less sleepy players were considered a "value pick" because they did stay with the original team. The baseball study analyzed the sleepiness scale of 40 randomly selected baseball players and found that players who reported higher levels of daytime sleepiness also had attrition rates of 57 percent to 86 percent, well above the 30 -- 35 percent MLB average.

Winter said measuring sleepiness could do more for a team than help it decide who to draft. "Addressing sleepiness in players and correcting the underlying issues causing sleepiness may help to prolong a player's career," he said.

Winter and his colleagues at Martha Jefferson Hospital Sleep Medicine Center and CNSM Consulting in Charlottesville, Va., used the Epworth Sleepiness Scale (ESS), a short questionnaire that can be helpful in detecting excessive daytime sleepiness. EDS is a common symptom of many sleep disorders such as obstructive sleep apnea.

The abstracts "Sleepiness as a predictor of draft value in the National Football League" and "Sleepiness as a predictor of player longevity within Major League Baseball" are being presented today at SLEEP 2012, the 26th annual meeting of the Associated Professional Sleep Societies (APSS) in Boston.

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New studies show connection between sleepiness and pro-athlete careers

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Senior Citizen Longevity & Statistics

Those Long Telomeres Inherited from an Older Father Give You Longevity

Short telomeres a cause of ill health that occurs with aging long telomeres promote slower aging

Fluorescence-stained chromosomes (red) on a microscope slide. Telomere sequences (yellow) reside at the ends of each chromosome. More about telomeres from University of Utah below main story.

June 13, 2012 - Senior citizens most of them, anyway - are fond of trying to find reasons they are going to live longer. Well, here is a new one for you to contemplate. Researchers say that if your father conceived you late in life, you probably inherited some life-extending benefits long telomeres.

Its all based on a biological assumption that a slow pace of aging requires the body to invest more resources in repairing aging cells and tissues.

Researchers from Northwestern University say that our bodies might increase these investments to slow the pace of aging if our father and grandfather waited until they were older before having children.

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Those Long Telomeres Inherited from an Older Father Give You Longevity