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Monitoring Protein Didn’t Improve Heart Failure Outcomes

(HealthDay News) -- Using the biomarker molecule known as brain natriuretic peptide (BNP) to guide treatment for older people with chronic heart failure did not improve the clinical outcome in most cases in a Swiss study.

There have been conflicting reports about the value of monitoring blood levels of BNP, a protein produced by stressed heart cells, for better management of heart failure. For example, a French study reported in 2007 found that BNP monitoring reduced deaths and hospitalizations in a 115-participant trial.

But the new study, published in the Jan. 28 issue of the Journal of the American Medical Association by physicians at University Hospital Basel, found that BNP-monitored therapy guidance generally did not improve 18-month survival or quality of life over conventional symptom-guided therapy.

All the people in the trial were 60 or older. All were hospitalized for heart failure, and all had BNP blood levels at least double the normal readings. Read more...

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Cholesterol—How Low Should It Go??

Q: THESE RESULTS FLY IN THE FACE OF WHAT FACT RESPONSES HAVE INDICATED. ANY COMMENT? DAVID J. KRIZMAN, MD

http://www.everydayhealth.com/heart-health/how-low-should-cholesterol-go.aspx?xid=nl_EverydayHealthDietandNutrition_20081221

Cholesterol—How Low Should It Go?
Bringing your cholesterol numbers down is an important part of improving your heart health.

By Arthur Agatston, MD, Everyday Health heart expert If you have established heart disease or are at high risk, aggressive cholesterol lowering is beneficial no matter what cholesterol levels you start with. There are a number of studies that demonstrate this.
The 1998 Air Force/Texas Atherosclerosis Coronary Prevention Study was different from prior statin investigations. In this study, the participants started with normal levels of total and LDL ("bad") cholesterol and no obvious signs of cardiovascular disease. Understandably, many people thought that giving statins to people with normal LDL cholesterol was "overkill." In truth, it turned out to be lifesaving. Compared to people who were given a sugar pill (placebo), those who took a statin had a 37 percent lower risk of having a heart attack, unstable angina, or sudden cardiac death. Read more...

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Are Too Many Older People Screened for Cancer?

(HealthDay News) -- Many older Americans get screened for colon, breast, prostate and cervical cancer even though guidelines recommend against routinely screening the elderly, a new study finds.

As the population of the United States continues to age, balancing good health care with costs will be a continuing battle, experts say. "In an era of escalating health care utilization and expenditures in the United States, identifying areas for cost containment while concurrently improving quality of care in our health care system is increasingly paramount," said lead researcher Keith Bellizzi, an assistant professor of human development and family studies at the University of Connecticut in Storrs.

"Perhaps this area of health care warrants further attention," Bellizzi added.

Currently, nearly 37 million people in the United States are 65 and older, and that number will probably double by 2030. Historically, older adults have been excluded from cancer clinical trials, so what is known about the effectiveness of screening in seniors is limited, he said.

The U.S. Preventive Services Task Force recommends against routine screening for breast, colorectal, and prostate cancer at age 75 and beyond, and advises against cervical cancer testing after 65, according to the study. Read more...

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