The duration of pre-ovulatory serum progesterone elevation before hCG administration affects the outcome of IVF/ICSI cycles

Study question

During controlled ovarian stimulation (COS), does the duration of premature serum progesterone (P) elevation before administration of hCG affect the outcomes of IVF/ICSI embryo transfer (-ET) cycles?

Summary answer

The duration of the premature serum P elevation is inversely related to the clinical pregnancy rate of IVF/ICSI-ET cycles.

What is known and what this paper adds

The majority of the previous studies only considered a single serum P measurement made on the day of hCG administration and the results of attempts to relate this to IVF/ICSI-ET outcomes were controversial. However, the effect of the duration of premature serum P elevation before the hCG administration on the outcomes of IVF/ICSI-ET cycles has not been studied well. Here we demonstrate that the duration of premature serum P elevation has a more significant inverse correlation than the absolute serum P concentration on the day of hCG administration with IVF/ICSI-ET outcomes.

Design

It is a retrospective, single-centre cohort study. A total of 1784 IVF and/or ICSI-ET cycles were included from October 2005 to June 2011.

Participants and setting

A total of 1784 patients underwent their IVF and/or ICSI-ET cycles in a university hospital IVF unit. The inclusion criteria include (i) age between 20 and 42 years and (ii) eligible indications for COS before IVF/ICSI.

Main results and the role of chance

The duration of premature serum P elevation to >1 ng/ml is significantly inversely associated with the probability of clinical pregnancy (odds ratio = 0.773, 95% confidence interval: 0.660–0.891, P < 0.001), after adjustment for possible confounders with multivariate logistic regression analysis. However, the significance of inverse correlation between the absolute serum P concentration on the day of hCG administration with clinical pregnancy rate decreased after adjustment.

Bias, confounding and other reasons for caution

The cutoff value we chose to define premature serum P elevation (P > 1.0 ng/ml) might not be able to be applied to different immunoassay kits and study population. The retrospective nature of this study inevitably might be influenced by some selection bias.

Generalizability to other populations

Older patients (>42 years) are excluded from our study.

Study funding/competing interest(s)

This study was supported in part by grants from the National Science Council (100-2314-B-002-022-MY3) and National Taiwan University Hospital (NTUH 100-S1555), Taipei, Taiwan. No competing interests are declared.

Trial registration number

nil.

Source:
http://humrep.oxfordjournals.org/rss/current.xml

Guidelines for infertility counselling in different countries: Is there an emerging trend?

BACKGROUND

It is widely accepted that infertility and involuntary childlessness, and the decision to engage with assisted reproduction technology (ART) services as a patient, donor or surrogate can entail wide-ranging psychosocial issues. Psychosocial counselling has, therefore, become valued as an integral element of ART services. The objective of this study was to begin to map out what exists globally by the way of guidelines for infertility counselling.

Methods

Data were analysed from formal guidelines produced by seven national infertility counselling bodies, onetransnational infertility counselling organization, reports of the American Society for Reproductive Medicine Ethics Committee and Practice Committee and the ESHRE Task Force on Ethics and Law. Additional sources of data were the International Infertility Counseling Organization and counselling colleagues internationally.

Results

Four broad areas concerning contemporary practice in infertility counselling are identified: (i) the legal mandate for counselling; (ii) eligibility credentials for individuals carrying out professional counselling activities; (iii) different forms of counselling and (iv) counselling practice in relation to specific elements of assisted reproduction treatment.

CONCLUSIONS

Internationally, the development of infertility guidelines is best described as a ‘work in progress’, although key trends are evident.

Source:
http://humrep.oxfordjournals.org/rss/current.xml

Smoking, drinking, being overweight have little effect on sperm count: study

Drinking, smoking or being fat make little difference to how well a mans sperm cells can swim, a new study has found.

The peer-reviewed findings to be published on Wednesday in the medical journal Human Reproduction fly in the face of the common advice that men having fertility problems should stick to a healthier lifestyle.

The study looked at sperm samples from 2,249 British men recruited from fertility clinics and andrology labs.

The researchers found that men who wore briefs rather than boxer shorts, had testes surgery, or did manual work that would expose them to chemicals, were more likely to have a low motile sperm count.

However, no relation was found to consumption of alcohol, use of tobacco or recreational drugs or high body mass index, the article says.

In fact, having very low body mass index appeared to have a negative impact on sperm quality, although that sample size was too minute to be meaningful, the study said.

One of the researchers said the results suggest that men shouldnt wait until they have developed a healthier lifestyle before they try to procreate, especially if age is a crucial factor for their spouses.

Success in fertility treatment is an issue for the couple and not simply the male partner the prime issue in delaying treatment is that success drops dramatically with the age of the female partner, said Nicola Cherry, an epidemiologist at the University of Albertas faculty of medicine.

Guidelines from the Public Health Agency of Canada and the Guide to Infertility booklet produced by Assisted Human Reproduction Canada both say that smoking and alcohol consumption decrease success rates.

Perhaps where fertility treatment is prohibitively expensive it seems better to suggest a healthy lifestyle rather than just to advise, keep trying, Dr. Cherry said.

More here:
Smoking, drinking, being overweight have little effect on sperm count: study

Evaluation of preparatory psychosocial counselling for medically assisted reproduction

BACKGROUND

This study evaluated couples' perceptions of preparatory psychosocial counselling prior to participation in medically assisted reproduction (MAR).

METHODS

Eighty-three couples about to undergo IUI treatment were asked about their expectations regarding a subsequent single psychosocial counselling session and assessed in terms of their levels of infertility-specific stress, anxiety and depressive symptoms. Afterwards, participants rated their satisfaction with different elements of the session.

RESULTS

Almost two-thirds of women and one-half of men expected counselling to be important, and the majority anticipated that the session would be helpful and informative. Views of preparatory counselling were significantly more positive afterwards, indicating that a focused session addressing issues of treatment concerns, goal setting and managing infertility stress was more beneficial than anticipated. Those experiencing higher levels of infertility-specific stress expected the counselling session to be more important, and elevated stress and greater utilization of social support were predictive of post-counselling satisfaction.

CONCLUSIONS

Preparatory psychosocial counselling provided with a specific and practical focus appears to be a potentially important and helpful service prior to MAR. Clinics should not assume that patients can accurately judge the benefits of counselling before actually engaging in the session. Identifying patients most likely to benefit and providing a clear rationale may further increase receptivity to this proactive counselling service. While patients characterize this intervention as beneficial, it is not yet known if these benefits translate into improved management of treatment procedures.

Source:
http://humrep.oxfordjournals.org/rss/current.xml

A press program of good stories from the world's leading event in reproductive medicine

Public release date: 14-Jun-2012 [ | E-mail | Share ]

Contact: Christine Bauquis christine@eshre.eu 32-499-258-046 European Society of Human Reproduction and Embryology

The annual meeting of ESHRE, the world's leading event in reproductive medicine, is only weeks away - and the press programme almost complete. Once again the meeting promises one of the best sources of news and features in fertility and reproductive medicine. This year's event will take place in Istanbul from 1st-4th July.

More than 8000 of the world's leading experts in reproduction are expected this year, and, from a total of more than 1700 abstracts of new research submitted, ten have been selected for the press programme.

The programme will comprise ten press releases (issued under embargo a few days in advance) and a news briefing on each of the three congress days. Here, investigators will describe their research and answer press questions on its scientific and public health implications.

Topics to be covered include:

The news briefings will take place at 10.30 am on Monday 2nd July and Tuesday 3rd July, and at 09.30 am on Wednesday 4th July. Each news briefing will cover three topics, with short presentations from investigators.

Press releases will be available on the ESHRE website once the embargoes have lifted, and otherwise issued a few days in advance under embargo. One press release suitably embargoed for Monday publications will also be issued.

ESHRE welcomes journalists to the meeting, and a serviced press room with support materials and wi-fi connection will be available. Registration is free to bona fide journalists on presentation of official press credentials.

ESHRE's media policy requires accreditation with a recognised press card or commissioning letter from an editor confirming the assignment. Before seeking registration, you should check ESHRE's media policy, which is accessible at http://tiny.cc/37cwfw

View post:
A press program of good stories from the world's leading event in reproductive medicine

Heavy Drinking, Smoking Won't Harm Men's Sperm

variety of beers

TUESDAY, June 12 (HealthDay News) -- When a man drinks to excess, smokes or otherwise behaves unhealthily, it probably won't damage his sperm, a new British study contends.

But, fertility experts who reviewed the new report, published June 12 in Human Reproduction, weren't in full agreement with the findings.

"I am concerned that this limited and isolated study will convey the wrong message to couples desiring to become parents," said Dr. Natan Bar-Chama, director of the Center of Male Reproductive Health at Mt. Sinai Hospital in New York City.

The study included more than 2,200 men from 14 fertility clinics around the United Kingdom who completed detailed questionnaires about their lifestyle habits. The researchers compared this information to the levels of swimming sperm ejaculated by the men.

[Read: Fatty Foods May Harm Men's Sperm.]

Some factors did impact sperm health. For example, men who had low levels of swimming sperm were 2.5 times more likely to have had prior testicular surgery, twice as likely to be black, and 30 percent more likely to have manual labor jobs, not wear boxer shorts (vs. briefs or no underwear), or not to have previously conceived a child.

On the other hand, the researchers also found that men's weight and their use of tobacco, alcohol and recreational drugs had little effect on levels of swimming sperm.

"Despite lifestyle choices being important for other aspects of our health, our results suggest that many lifestyle choices probably have little influence on how many swimming sperm [men] ejaculate," Dr. Andrew Povey, from the University of Manchester's School of Community Based Medicine, said in a university news release.

The findings suggest that lifestyle advice given to infertile men needs to be changed, the researchers added.

More here:
Heavy Drinking, Smoking Won't Harm Men's Sperm

Booze and fags fine for fertility

12 June 2012 Last updated at 19:45 ET By James Gallagher Health and science reporter, BBC News

Lifestyle advice given to tackle male infertility may be futile and could delay other options, according to researchers in the UK.

Their study in the journal Human Reproduction said smoking, alcohol consumption and being obese did not affect semen quality.

However, they warned that avoiding them was still "good health advice".

Wearing boxer shorts rather than tighter underwear was linked to higher sperm levels.

Advice for doctors by the National Institute for Health and Clinical Excellence says men should be warned about the impact of smoking, drinking and taking recreational drugs on their sperm.

A study by researchers at the Universities of Sheffield and Manchester compared the lifestyles of 939 men with poor sperm quality with 1,310 men with normal sperm quality.

There is no need for them to become monks just because they want to be a dad

The study showed there was little difference in the number of mobile sperm between patients who never smoked and those who had a 20-a-day habit.

There was "little evidence" that recreational drug use, a high BMI or excessive alcohol consumption affected sperm quality.

More here:
Booze and fags fine for fertility

Unhealthy lifestyles have little impact on sperm quality

Public release date: 12-Jun-2012 [ | E-mail | Share ]

Contact: Aeron Haworth aeron.haworth@manchester.ac.uk 44-161-275-8383 University of Manchester

Lifestyle advice given by doctors to men diagnosed with infertility should be radically overhauled according to research published today (Wednesday).

Current guidelines from the National Institute for Clinical Excellence1 advise doctors to warn infertile men about the dangers of smoking, alcohol consumption and recreational drug use, as well as the risks of being overweight and wearing tight underwear.

However, a team of scientists from the Universities of Manchester and Sheffield have found that many common lifestyle choices make little difference to male fertility, based on how many swimming sperm men produce.

The study, published in the medical journal Human Reproduction, recruited 2,249 men from 14 fertility clinics around the UK2 and asked them to fill out detailed questionnaires about their lifestyle. The information was then compared between 939 men who ejaculated low numbers of swimming sperm and a control group of 1,310 men who produced higher numbers.

The research found that men who ejaculated low numbers of swimming sperm were 2.5 times more likely to have had testicular surgery, twice as likely to be of black ethnicity, and 1.3 times more likely to be in manual work, not wear boxer shorts, or not had a previous conception. Surprisingly, men's use of recreational drugs, tobacco and alcohol, as well as their weight measured by their body mass index (BMI), had little effect3.

Dr Andrew Povey, from the University of Manchester's School of Community Based Medicine, said: "Despite lifestyle choices being important for other aspects of our health, our results suggest that many lifestyle choices probably have little influence on how many swimming sperm they ejaculate. For example, whether the man was a current smoker or not was of little importance. The proportion of men who had low numbers of swimming sperm was similar whether they had never been a smoker or a smoker who was currently smoking more than 20 cigarettes a day. Similarly, there was little evidence of any risk associated with alcohol consumption.

"This potentially overturns much of the current advice given to men about how they might improve their fertility and suggests that many common lifestyle risks may not be as important as we previously thought. Delaying fertility treatment then for these couples so that they can make changes to their lifestyles, for which there is little evidence of effectiveness, is unlikely to improve their chances of a conception and, indeed, might be prejudicial for couples with little time left to lose."

In assessing male fertility, the team chose to use the number of swimming sperm men ejaculated because this broadly correlates with how fertile a man is likely to be and also often determines the type of fertility treatment that may be used if required.

View original post here:
Unhealthy lifestyles have little impact on sperm quality

What Happens When Ideas Have Sex?

Part 1 of the TED Radio Hour episode Where Ideas Come From. Watch Matt Ridley's full Talk When Ideas Have Sex on TED.com

"There's a sense in which this meeting and mating of ideas has ... a momentum of its own" Matt Ridley

"There's a sense in which this meeting and mating of ideas has ... a momentum of its own" Matt Ridley

At TEDGlobal 2010, author Matt Ridley showed how, throughout history, the engine of human progress has been the meeting and mating of ideas to make new ideas basically "ideas having sex with each other." The sophistication of the modern world lies not in individual intelligence or imagination, he says, instead it's a collective enterprise. That means it's not important how clever individuals are; what really matters is how smart the collective brain is.

About Matt Ridley

In his book The Rational Optimist, British author Matt Ridley sweeps the entire arc of human history to argue that it is our habit of trade, idea-sharing and specialization that has created the collective brain which set human living standards on a rising trend.

Ridley's previous works include Genome, which picks apart the Human Genome Project chromosome by chromosome, and Nature via Nurture, exploring the age-old question: Does nature or nurture that makes us who we are?

About the Entrepreneurs

Vijaya Thakur was working for an organization doing relief work in the Democratic Republic of Congo when she started thinking that relief could be done better at a smaller scale. She left her job and founded the Resolve Network, which aims to promote peace in Eastern Congo through literacy and microfinance.

While working for the Peace Corps in Morocco, Dan Driscoll kept seeing local artists and artisans get underpaid by foreign art dealers for their wares. Wanting to help them earn more revenue, Driscoll founded Anou, a Web-based platform for artisans around the world to sell their wares online.

Read the rest here:
What Happens When Ideas Have Sex?

Smoking, drinking, being fat have little effect on sperm count: study

Drinking, smoking or being fat make little difference to how well a mans sperm cells can swim, a new study has found.

The peer-reviewed findings to be published on Wednesday in the medical journal Human Reproduction fly in the face of the common advice that men having fertility problems should stick to a healthier lifestyle.

The study looked at sperm samples from 2,249 British men recruited from fertility clinics and andrology labs.

The researchers found that men who wore briefs rather than boxer shorts, had testes surgery, or did manual work that would expose them to chemicals, were more likely to have a low motile sperm count.

However, no relation was found to consumption of alcohol, use of tobacco or recreational drugs or high body mass index, the article says.

In fact, having very low body mass index appeared to have a negative impact on sperm quality, although that sample size was too minute to be meaningful, the study said.

One of the researchers said the results suggest that men shouldnt wait until they have developed a healthier lifestyle before they try to procreate, especially if age is a crucial factor for their spouses.

Success in fertility treatment is an issue for the couple and not simply the male partner the prime issue in delaying treatment is that success drops dramatically with the age of the female partner, said Nicola Cherry, an epidemiologist at the University of Albertas faculty of medicine.

Guidelines from the Public Health Agency of Canada and the Guide to Infertility booklet produced by Assisted Human Reproduction Canada both say that smoking and alcohol consumption decrease success rates.

Perhaps where fertility treatment is prohibitively expensive it seems better to suggest a healthy lifestyle rather than just to advise, keep trying, Dr. Cherry said.

More here:
Smoking, drinking, being fat have little effect on sperm count: study

CHR Paper Reporting on Live Birth Rates with Low AMH Levels Receives Prestigious Austrian Award

New York, NY (PRWEB) June 11, 2012

A recent paper(1) by researchers at the Center for Human Reproduction (CHR) in New York City which describes reasonable live birth chances in women with extremely low ovarian reserve received the prestigious Austrian Hugo Husslein Prize. The prize is awarded biannually by the Austrian Society of Obstetrics and Gynecology.

The paper, published in the journal Human Reproduction, reports on the moderate but reasonable live birth chances in women with extremely low ovarian reserve, demonstrated by either completely undetectable or very low anti-Mllerian hormone (AMH) levels. Women in the study were also older, with mean age approaching 41. Despite these poor prognostic indicators, the authors were able to establish clinical pregnancies in 15.6% of these women.

With extremely low serum AMH levels, moderate but reasonable pregnancy and live birth rates are still possible. Extremely low AMH levels do not appear to represent an appropriate marker for withholding fertility treatment, concluded the paper.

Based on CHRs protocol, women in the study received DHEA supplementation prior to starting their IVF cycles. While the result of this study may not be applicable to women without DHEA supplementation, the results brings hope to women struggling to achieve pregnancy after 40, as well as to younger women with premature ovarian aging (POA).

It was a great honor to receive the prize, says Andrea Weghofer, MD, Associate Professor of Obstetrics and Gynecology, Medical University Vienna a Visiting Associate Scientist at CHR and lead author of the study. She continues: but the real honor was in demonstrating that these women, who are likely to be turned away by most fertility centers based on poor prognosis, can still be helped with their own eggs, with reasonable success rates.

This really echoes our philosophy at CHR, adds Norbert Gleicher, MD, Medical Director and Chief Scientist of CHR. We never turn away patients who fully understand their limited chances, and our entire clinical team literally fights for every egg and every embryo.

CHR, over the years, has made many breakthroughs in treating women with poor prognosis, who failed at other centers or have been refused treatments because of presumed small chances. The centers IVF success rates in such patients have been improving year to year, reaching another record height in 2011.

(1)Weghofer A, Dietrich W, Barad DH, Gleicher N. Live birth chances in women with extremely low serum anti-Mllerian hormone levels. Hum Reprod 2011;26(7):1905-9.

About Center for Human Reproduction The Center for Human Reproduction (CHR, http://www.centerforhumanreprod.com/), is one of the worlds leading fertility centers in New York City with international patient following. CHR has a worldwide reputation as the "fertility center of last resort," specializing in treatment of infertility in women with diminished ovarian reserve due to advanced age or due to premature ovarian aging (POA). Dr. Weghofer and Dr. Gleicher are available for further comments.

Go here to see the original:
CHR Paper Reporting on Live Birth Rates with Low AMH Levels Receives Prestigious Austrian Award

What Are the Roots of Gender Inequality? Women's Rights, Race and Reproduction

Newswise Throughout history, women have faced intense discriminationfrom a lack of legal rights and very little independence from their husbands, to being thought to have inferior brains. In many societies, women have long been viewed as less than fully human.

American society has come a long way in recognizing and protecting womens humanity and human rights. However, women will always be fundamentally different than men because of their ability to bear children. We are reminded of this by current political debates concerning abortion and contraception, which some have called a war on women.

What are the roots of gender inequality? How have the challenges faced by women changed over time? Sally Kitch, an Regents Professor of Women and Gender Studies at Arizona State University, has spent many years exploring the reasons why the world sees men and women so differently. To find answers, she has explored questions ranging from the gendered origins of race to American utopian communities.

The intersection of race and gender Kitch, who is also the director of ASUs Institute for Humanities Research, a research unit in ASU's College of Liberal Arts and Sciences, covered 300 years of history tracing the connection between gender and race in her book, The Specter of Sex: Gendered Foundations of Racial Formation in the United States (State University of New York Press, 2009). She discovered that gender inequities have been central to societies for centuries, but race is a very modern idea.

One thing we know about race is that it doesnt exist. Its not a biological category, Kitch says. Some believe that groups of people who share similar physiological characteristics constitute races, but race is really a system imposed by historical, cultural and political processes, Kitch says. Genetically speaking, a black and white person may have more in common than two people of the same race. How, then, did race become so significant?

European explorers of the sixteenth century noticed differences like skin color when they encountered natives of other continents, but they were even more interested in the unfamiliar sexual and reproductive practices of other cultures, Kitch says.

The Europeans thought that cultures in which men and women werent that different in terms of their behavior or appearance were uncivilized, Kitch says. Marriage customs, sexual practices, and even whether or not women experienced pain during childbirth (it was considered more civilized to feel pain) were all important distinctions used to disparage certain groups and, eventually, define races.

That gave me the insight that racial characteristics really evolved on the basis of comparative gender characteristics, Kitch says. My work provides the backstory of the concept of intersectionality by showing how race and gender judgments evolved together and influenced one another.

Differences in gender behavior also served as Europeans justification for using slavery to further their own economic interests. When Europeans began to enslave Africans, they didnt start with their skin color to explain why, Kitch says. Instead, they used observations on sexual behavior and religious practices to decide the African culture was inferior.

A history of discrimination To understand how gender continued to influence race over time, Kitch traced five racial groups in the U.S. from the Colonial period to the mid-20th century American Indians, African-Americans, Latinos, Asian-Americans and European whites. After exploring the roots of racial formation, she focused on the categories of bodies, blood and citizenship, finding evidence that gender and sex were foundations of racial judgment throughout the centuries.

View post:
What Are the Roots of Gender Inequality? Women's Rights, Race and Reproduction

Human reproduction agency has little to show for $30-million

A federal agency that has been unable to deliver on its mandate to oversee assisted human reproduction and is now slated for closure spent nearly $50,000 to relocate its president to Vancouver as it was awaiting a Supreme Court ruling that would strip away much of its responsibilities.

When Elinor Wilson was appointed to head Assisted Human Reproduction Canada (AHRC) in 2007, she refused to move from Ottawa to the agency headquarters that had been established in British Columbia. So the small staff has operated out of two offices one in Ottawa and a lavish bureau on the West Coast that was never fully occupied and was traded last year for a smaller location.

But in October, 2011, as she was waiting for a Supreme Court ruling that divested her agency of many of its duties, Dr. Wilson had a change of heart and moved to Vancouver. That relocation cost $49,635, agency staff said Thursday.

Since that time, Dr. Wilson has spent more than $50,000 travelling back to Ottawa on behalf of the AHRC, whose activities are unclear given that it has never been provided with the regulations required to do its job. Repeated requests for interviews with Dr. Wilson this week were refused.

The agency, which was created by the former Liberal government and set up by the Harper Conservatives, was told in the March federal budget that its doors would be closed and any functions that are still being performed would be taken over by Health Canada.

There are still five staff members in the AHRCs Ottawa office and two in Vancouver. The operation is expected to wind down by the end of March, 2013.

The agency was supposed to enforce the Assisted Human Reproduction Act with the power to inspect fertility clinics, and issue, suspend and revoke their licences to operate. It was also expected to set rules for stem-cell research projects and make regulatory recommendations to the federal health minister.

But the Supreme Court in December, 2010, determined that provinces, and not the federal government, had the power to regulate and licence doctors and clinics offering fertility treatments a ruling that wiped out a large part of the agencys reason for existence. And Health Canada has written just one of the roughly 30 regulations that were required to put the Assisted Human Reproduction Act in effect.

According to the budget documents, the demise of the AHRC will save the government $9.5-million a year.

But Franoise Baylis, a bioethics professor at Dalhousie University who resigned as a member of the agencys board in 2010, said the government knows full well that thats not true because, even though the agency has been allotted $10-million in federal funding every year, it has never managed to spend that amount.

Read more:
Human reproduction agency has little to show for $30-million

Reverse book ban, says Human Rights Watch

The Malaysia government should respect the right to free expression and immediately reverse its ban on a book, Allah, Liberty and Love, by Canadian Muslim writer Irshad Manji, Human Rights Watch has said.

Home Affairs Minister Hishammuddin Hussein banned the book, which deals with the reconciliation of faith and freedom, because it is prejudicial to morality and public order, according to the Federal Government Gazette on 29 May 2012.

Banning books is nothing short of cowardly, said Elaine Pearson, deputy Asia director at Human Rights Watch. Malaysian society is fully capable of discussing the issues of the day without the government telling them what they can or cant read.

Deputy Home Affairs Minister Abu Seman Yusop said that Allah, Liberty and Love was banned because it is believed to have elements that can deviate Muslims from their faith, Islamic teachings and elements which insulted Islam and has received numerous complaints. He added that a report from the Department of Islamic Development Malaysia (Jakim) indicated that the book had elements that could confuse the public.

On 29 May, some 20 officers from the Selangor Islamic Affairs Department (Jais) with a warrant from an Islamic (Shariah) court, raided the offices of ZI Publications, which published the Malay language edition of the book. They seized about 180 copies and took Ezra Zaid, the publisher, to Jais headquarters in the town of Shah Alam. He was released on RM1800 (US$570) bail and has not yet been charged.

Under the Printing Presses and Publications Act, the home affairs minister has absolute discretion to ban books. The ban, effective throughout Malaysia, extends to possession of the book in either Malay or English and to its importation, production, reproduction, publishing, sale, issue, circulation, [and] distribution. The ban also extends to copies, extracts, translation, prcis, and paraphrasing.

Manji arrived in Malaysia on 15 May to take part in a promotional book tour, but learned that scheduled events had been cancelled, in part due to government pressure. Manjis first book, The Trouble with Islam Today, published in 2004, also was controversial.

The ban on Allah, Liberty and Love violates the right to freedom of expression as provided under article 19 of the Universal Declaration of Human Rights. Free expression entails the right both to impart and receive information and ideas, Human Rights Watch said.

Malaysian authorities say they are protecting morality by banning Manjis book, but this is just old-fashioned state repression, Pearson said. Malaysia will have a stronger claim to being a rights-respecting democracy that deserves its seat on the United Nations Human Rights Council once it starts permitting Malaysians the right to seek information and to hold opinions without interference.

The rest is here:
Reverse book ban, says Human Rights Watch

Seg _ 1 -Suvarnanews – Something Special – Reproductive System – 29 May 12 – Suvarna News – Video

30-05-2012 05:31 Suvarna News 24X7 - 29 May 2012 In the human reproductive process, two kinds of sex cells, or gametes, are involved. The male gamete, or sperm, and the female gamete, the egg or ovum, meet in the female's reproductive system to create a new individual. Both the male and female reproductive systems are essential for reproduction.

Original post:
Seg _ 1 -Suvarnanews - Something Special - Reproductive System - 29 May 12 - Suvarna News - Video

Seg _ 2 -Suvarnanews – Something Special – Reproductive System – 29 May 12 – Suvarna News – Video

30-05-2012 05:35 Suvarna News 24X7 - 29 May 2012 In the human reproductive process, two kinds of sex cells, or gametes, are involved. The male gamete, or sperm, and the female gamete, the egg or ovum, meet in the female's reproductive system to create a new individual. Both the male and female reproductive systems are essential for reproduction.

Read more from the original source:
Seg _ 2 -Suvarnanews - Something Special - Reproductive System - 29 May 12 - Suvarna News - Video

A new method for picking the ‘right’ egg in IVF

In a groundbreaking study, Yale School of Medicine researchers and colleagues at the University of Oxford have identified the chromosomal make-up of a human egg. This discovery may soon allow them to avoid using abnormal or aneuploid eggs during infertility treatments, and instead to pick eggs that are healthy enough for a successful in vitro fertilization (IVF) cycle.

The results are published in the May issue of the journal Human Reproduction.

Only a few oocytes (eggs) per IVF treatment cycle are able to produce a pregnancy because many eggs have the wrong number of chromosomes. If the egg is missing a chromosome or has an extra chromosome, this is referred to as aneuploidy. This problem increases as women age.

Oocytes are surrounded by cells, called cumulus cells, which regulate and assist the process of egg maturation. In this study, Yale Fertility Center director Dr. Pasquale Patrizio, and Dagan Wells of the University of Oxford studied genes expressed in the cumulus cells. They were able to identify a set of genes that are less active in cells that are associated with abnormal eggs.

They characterized two genes SPSB2 and TP5313 and found that the expression of these genes was consistently underrepresented in cumulus cells that surrounded abnormal eggs, while these same genes were normally expressed in eggs with the correct number of chromosomes.

The identification of these genes in cumulus cells can serve as a novel, non-invasive marker to identify abnormal oocytes and thus ultimately improve IVF success rates, said Patrizio, professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale. We can use cumulus cells surrounding the eggs to gain insight into the health of an egg. These cells are now able to inform us about the chromosomal makeup of an egg. This can help us know if it is the right egg to be fertilized and produce a baby.

This finding opens up the possibility of a safe, effective, and inexpensive way of identifying healthy eggs, potentially lowering the risks of miscarriage and Down syndrome, said Wells. By conducting these tests before eggs are fertilized, ethical concerns about analysis of human embryos are avoided.

Other authors on the study include Elpida Fragouli, Amy E. Lager, and Umit A. Kayisli.

Wells is supported by the National Institute for Health Research Biomedical Research Centre, Oxford; the work was also supported by a grant from Gema Diagnostics, Inc.

Citation: Human Reproduction doi: 10.1093/humrep/des170

See the original post here:
A new method for picking the ‘right’ egg in IVF

Cynthia Rothschild: Oh, the Drama! The UN Human-Rights System Tackles Sexual Orientation and Gender Identity

The United Nations hosted its first-ever high-level panel on violence and discrimination based on sexual orientation and gender identity in early March. Convened by the government of South Africa, some, including me, would argue that this event is at least 10 years overdue. Nonetheless, seeing Ban Ki Moon, the Secretary General of the U.N., in an opening video statement uneqivocally offer his support in this struggle was extraordinary:

I've been doing LGBT human-rights work for two decades, and this was probably the "gayest," or certainly the most theatrical, U.N. moment I've encountered. As house lights lowered within the U.N. Human Rights Council in Geneva, strips of lighting on hundreds of desks in the room cast an eerie florescent glow. The ceiling, a three-dimensional, wildly colored, apocalyptic landscape, was set in emergency-lighting haze as a giant, onscreen Secretary General implored states to address and prevent violations. Pretty moving stuff, actually. With many LGBT- and sexual-rights activists attending from global south and north alike, the Council was duly queered and filled with intrigue.

This event was a landmark within the U.N. system, but it represents a particular win amidst a rollercoaster of to and fro in the political landscape of sexual rights, and specifically sexual orientation and gender identity ("SOGI," as we now call it), within the U.N. The backlash against any "progressive" or feminist focus on sexuality -- including claims for autonomous decision making about sex or reproduction, or sexuality education, or even freedom from discrimination -- is fierce and crosses continents with dizzying speed.

While the SOGI panel was breaking new ground in Geneva, at literally the same time at the U.N. in New York, the Holy See (which functions as a state within the U.N.), conservative governments, and a handful of U.S. right-wing organizations were boldly doing damage at the Commission on the Status of Women, the U.N.'s annual meeting on rights of women. Their goals were tried and true: In government negotiations, promote a monolithic heterosexual notion of "the" family; block promotion of comprehensive sexuality education; weaken any language that could support women's access to abortion or reproductive-health services, and stifle references to "key populations" affected by the AIDS pandemic -- specifically men who have sex with men, or sex workers.

In these spaces of global governance, the resistance to women's and LGBT rights is profound and often revealed in side programming alongside the official negotiations. Back in Geneva, two days after the pioneering SOGI panel, the Holy See hosted a hastily put-together, somewhat veiled anti-gay, unofficial event at the Human Rights Council. Abortion-related rights provide the Holy See's other rallying point, with support of conservative governments and many U.S. right-wing groups. Some of the unofficial U.N. events these groups host are (this can't be said diplomatically) mindblowing: some promote the value of breastfeeding but maintain a main plot that links abortion to breast cancer. For the record, the World Health Organization debunked this connection years ago. These events come across as desperate attempts to roll back the clock or, in this case, the legacy of progressive social movements, scientific evidence-based study, and even international human-rights law. And they're painful to sit through, too.

OK, so that was March in the UN. Bring on April and the U.N. Commission on Population and Development (CPD), another annual, week-long, governmental meeting in New York attended by many sexual- and reproductive-rights and right-wing organizations. Fasten your seatbelts: Here's another swervy ride.

The CPD always has a theme related to health; this year's was "adolescents and youth." Remarkably, the CPD produced a resolution calling on governments to protect human rights of adolescents and youth "to have control over and decide freely and responsibly on matters related to their sexuality, including sexual and reproductive health," and to provide them with "evidence-based comprehensive education on human sexuality." These are big wins that fly in the face of conservative efforts to regulate sexuality of young people. But these gains came with compromises. Gender- and sexual-rights language became lightning rods, because they were seen as "covers" for sexual orientation and gender identity.

So even as an official human-rights panel on sexual orientation and gender identity takes place in one U.N. site, the ideas supporting that work become lynchpins in another U.N. venue 3,000 miles away. And even when allies try to focus on the daily violence and discrimination LGBT people face in all regions, what's heard by those in opposition is entirely different: They hear (because they want to) "demise of marriage," "the ruin of the family," and "the end of child bearing."

There was a not-very-interesting walkout by some governments as the official panel on sexual orientation and gender identity began at the Council. In fact, some of the same delegates who left the room were spotted in the overflow viewing gallery minutes later. Activism lesson: If you're going to stage a walkout, at least leave the building. Their opposition generally rested on weak and manipulated arguments about international law: "Homosexuality is a 'Western import,' is not mentioned in the Universal Declaration of Human Rights, and has no place being discussed in a context of international law," or, "This discussion is about affording 'special rights' to a specific group."

These arguments are, of course, paper-thin. The human-rights framework argues that all people should be able to enjoy all human rights, and that no one should be subjected to violence (including torture, extrajudicial killing, or violence in the home) or discrimination (including arbitrary arrest, or denial of education or health care).

See the original post here:
Cynthia Rothschild: Oh, the Drama! The UN Human-Rights System Tackles Sexual Orientation and Gender Identity

AZFa protein DDX3Y is differentially expressed in human male germ cells during development and in testicular tumours: new evidence for phenotypic plasticity of germ cells

BACKGROUND

DDX3Y (DBY), located within AZoospermia Factor a (AZFa) region of the human Y chromosome (Yq11), encodes a conserved DEAD-box RNA helicase expressed only in germ cells and with a putative function at G1–S phase of the cell cycle. Deletion of AZFa results most often in germ cell aplasia, i.e. Sertoli-cell-only syndrome. To investigate the function of DDX3Y during human spermatogenesis, we examined its expression during development and maturation of the testis and in several types of testicular germ cell tumours (TGCTs), including the pre-invasive carcinoma in situ (CIS) precursor cells which are believed to originate from fetal gonocytes.

METHODS

DDX3Y protein expression was analysed during development in different tissues by western blotting. The localization of DDX3Y in normal fetal and prepubertal testis tissue of different ages as well as in a series of distinct TGCT tissue samples (CIS, classical seminoma, spermatocytic seminoma, teratoma and embryonal carcinoma) was performed by immunohistochemistry.

RESULTS

Germ cell-specific expression of DDX3Y protein was revealed in fetal prospermatogonia but not in gonocytes and not before the 17th gestational week. After birth, DDX3Y was expressed at first only in the nuclei of Ap spermatogonia, then also in the cytoplasm similarly to that seen after puberty. In CIS cells, DDX3Y was highly expressed and located predominantly in the nuclei. In invasive TGCT, significant DDX3Y expression was found in seminomas of the classical and spermatocytic type, but not in somatically differentiated non-seminomas, consistent with its germ-cell specific function.

CONCLUSIONS

The fetal germ cell DDX3Y expression suggests a role in early spermatogonial proliferation and implies that, in men with AZFa deletion, germ cell depletion may begin prenatally. The strong expression of DDX3Y in CIS cells, but not in gonocytes, indicates phenotypic plasticity of CIS cells and suggests partial maturation to spermatogonia, likely due to their postpubertal microenvironment.

Source:
http://humrep.oxfordjournals.org/rss/current.xml

CD147 regulates apoptosis in mouse spermatocytes but not spermatogonia

BACKGROUND

Spermatogenesis is maintained by a dynamic balance between germ cell proliferation and apoptosis. Previous study has demonstrated that CD147 knockout mice are infertile with arrested germ cells. However, the question of whether and how CD147 may be involved in the apoptotic process during spermatogenesis remains elusive. The aim of this study was to evaluate the role of CD147 in the regulation of germ cell apoptosis in mice.

METHODS

CD147 function was blocked by anti-CD147 antibody in GC-1 (immortalized spermatogonia) and GC-2 (immortalized spermatocytes) cell lines and in testicular germ cells in vivo. Testes size and weight were examined after injection of anti-CD147 antibody into the seminiferous tubules of severe combined immunodeficiency mice. Germ cell apoptosis was determined by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and levels of p53 and two effectors, caspase 3 and poly ADP-ribose polymerase (PARP), using western blots.

RESULTS

The size and weight of the CD147-immunodepleted testes were decreased compared with that in control testes (P < 0.001). The TUNEL assay showed an increase in the number of apoptotic spermatocytes (P < 0.001 versus control) but not spermatogonia in Stages XI–XII of CD147-immunodepleted testes. In addition, in vitro experiments demonstrated that CD147 immunodepletion induced an increase in apoptosis in GC-2 cells (P < 0.001 versus control) but had no effect on GC-1 cells. Moreover, deprivation of CD147 induced apoptosis in spermatocytes through a p53-independent mechanism, which led to caspase 3 and PARP activation.

CONCLUSIONS

We have demonstrated that immunodepletion of CD147 induces p53-independent apoptosis in mouse spermatocytes but not spermatogonia.

Source:
http://humrep.oxfordjournals.org/rss/current.xml