Violin played by band on sinking Titanic on display in Branson, Mo. – KY3

"And the band played on..."

That well-known phrase is forever linked to the 1912 sinking of the Titanic as the band aboard the ill-fated ship played as passengers boarded the lifeboats.

Believe it or not a million-dollar artifact from that band that's survived for over a century will be on display at the Titanic Museum in Branson from February 8-June 15.

The museum is a reproduction of both the inside and outside of the legendary British passenger liner that sank in the early morning hours of April 15, 1912 after striking an iceberg on its maiden voyage in the North Atlantic Ocean. Of the estimated 2,224 passengers and crew aboard more than 1,500 died, making it one of the deadliest peacetime commercial marine disasters.

The Titanic museum in Branson and its sister-facility in Pigeon Forge, Tenn. have more than 400 artifacts from the actual ship but this one about to go on display in Branson is the most valuable and iconic.

"The most important piece of Titanic memorabilia in existence," said Andrew Aldridge of the Aldridge Auction Home in Great Britain, the firm that represents the anonymous owner of the piece.

"For us to have it now is incredible," added Paul Burns, the curator at the Branson Titanic Museum. "We're extremely lucky."

So what is it?

It's the actual violin played by bandleader Wallace Henry Hartley as his eight-piece band stood on the deck of the Titanic serenading passengers with hymns to try and calm them during the chaotic moments as they jumped on the lifeboats.

The band has become as much a part of the Titanic lore as the iceberg itself, recognized for their heroic gesture in the face of certain death. They've been an important part of any story of the Titanic's sad recounting, from books to movies, and the violin is an amazing survivor of that horrible night.

"If this violin could talk what incredible stories it could tell," Burns said.

Hartley, the bandleader who owned the violin, did not survive the sinking. His body was recovered two weeks after the disaster with a music case strapped to his body.

That case, which is also still around, is credited with why the violin was able to endure the cold, wet conditions and remain intact.

"When Wallace went into the water he had a valise, a big leather bag, and the violin was held within that valise," Aldridge explained. "That kept most of the water off it."

"Also the life preserver (Hartley was wearing) would have allowed the person's body to be two-thirds out of the water," Burns said of the Titanic's flotation devices. "So the violin really set out of the water inside the leather case."

Over the next century the violin went from Wallace's fiance to the Salvation Army to a music teacher to her student before the current anonymous owner bought it for the $1.7 million price tag.

The violin's authentication came from forensic testing that proved it had been in the waters of the North Atlantic and the presence of a metal plate on the front of the violin.

"On the fishplate (a flat piece of metal) it says, 'To Wallace on the occasion of our engagement. From Maria,'" Aldridge said. "And Maria Robinson was Wallace's fiance."

As you would expect the violin is handled like a baby, kept in a climate-controlled environment on a specially-made acrillic stand.

"When we place it on the stand we will take the weight completely off the violin so it will not rest on its own weight," Burns said in explaining that the wood portion of the violin is the most critical part to keep from aging.

Mary Kellogg, the co-owner and COO of the Titanic Museum, estimates that the violin is worth even more now since it is a one-of-a-kind item, and it's strange when you consider that this small musical instrument is worth much more than the million-dollar Grand Staircase that the museum recreated from the original Titanic that includes gold railings and an ornate ceiling and chandelier.

But the real reason the violin is the most valuable of all the Titanic artifacts is not what it is, but what it represents.

It's all that's left of a tragic sacrifice by eight men.

"The most selfless act you can imagine," Aldridge said of their heroics. "They're giving their life to comfort and soothe those around them."

"This represents all that," Burns said, pointing to the violin. "It's the most precious. What it represents, the icon, the human interest side of this, is the key to Titanic living on."

The violin will be on display in Branson from February 8-June 15. The museum is open daily at 9 a.m. and reservations are strongly suggested, especially during spring break times.

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Violin played by band on sinking Titanic on display in Branson, Mo. - KY3

Books about life in the Anthropocene – Yale Climate Connections

(Photo credit: NASA)

New years that end in zeros often prompt longer-range reflections. Not just What does the New Year hold? but What might the new decade bring? (as with 2020) or even What should we hope for in the new century or new millennium? (as happened with 2000).

And when that turn in the calendar coincides with unprecedented and catastrophic wildfires, such as those having ravaged large parts of Australia, then an even more foreboding question might be asked: In what new age are we living?

The titles selected for this months bookshelf provide several different answers to this last question, but all agree that the name of this new age is the Anthropocene, the geological age in which humans are leaving the most indelible marks on the planet.

It has been three years since Yale Climate Connections first bookshelf on the Anthropocene. All 16 of the titles listed below 12 with covers and blurbs, four without have been published since then. This newer set of titles also considers the Anthropocene from a wider variety of perspectives: the Earth and life sciences, the social sciences, the humanities, and the arts.

As always, the descriptions of the books are adapted from copy provided by the publishers. When two dates of publication are listed, the latter is the date for the release of the paperback edition.

Anthropocene: A Very Short Introduction, by Eric C. Ellis (Oxford University Press 2018, 208 pages, $11.95 paperback)

The Anthropocene, as the proposed new epoch has been named, is regularly in the news. This Very Short Introduction explains the science behind the Anthropocene and the many proposals about when to mark its beginning: The nuclear tests of the 1950s? The beginnings of agriculture? The origins of humans as a species? Erle Ellis considers the many ways that the Anthropocenes evolving paradigm is reshaping the sciences, stimulating the humanities, and foregrounding the politics of life on a planet transformed by humans. The Anthropocene remains a work in progress. Is this the story of an unprecedented planetary disaster? Or of newfound wisdom and redemption? Ellis offers an insightful discussion of our role in shaping the planet, and how this will influence our future on many fronts.

The Human Planet: How We Created the Anthropocene, by Simon L. Lewis and Mark A. Maslin (Yale University Press 2018, 480 pages, $25.00)

Meteorites, mega-volcanoes, and plate tectonics the old forces of nature have transformed Earth for millions of years. They are now joined by a new geological force humans. Our actions have driven Earth into a new geological epoch, the Anthropocene. For the first time in our home planets 4.5-billion-year history a single species is increasingly dictating Earths future. To some the Anthropocene symbolizes a future of superlative control of our environment. To others the illusion of our mastery over nature. Thus the Anthropocene evokes a heady mix of science, philosophy, and politics linked to our deepest fears and utopian visions. Tracing our environmental impacts through time, scientists Simon Lewis and Mark Maslin reveal a new outlook for the future of humanity in the unstable world we have created.

The Anthropocene as a Geological Time Unit: A Guide to the Scientific Evidence and Current Debate, edited by Jan Zlasiewicz, Colin N. Waters, Mark Williams, and Colin P. Summerhayes (Cambridge University Press 2019, 382 pages, $62.99)

This book presents the evidence for defining the Anthropocene as a geological epoch, written by the international team analyzing its potential addition to the geological time scale. The evidence ranges from chemical signals arising from pollution, to landscape changes associated with urbanization, and biological changes associated with species invasion and extinctions. Global environmental change is placed within the context of planetary processes and deep geological time, allowing the reader to appreciate the scale of human-driven change and compare the global transition taking place today with major transitions in history. This is an authoritative review of the Anthropocene, crossing scientific, social science and humanities disciplines.

The Politics of the Anthropocene, by John S. Dryzek and Jonathan Pickering (Oxford University Press 2019, 224 pages, $26.00 paperback)

The Politics of the Anthropocene considers how human institutions, practices, and principles need to be re-thought in response to the challenges of the Anthropocene, the emerging epoch of human-induced instability in the Earth system and its life-support capacities. The world remains stuck with practices and modes of thinking that were developed in the Holocene, toward the end of which modern institutions such as states and capitalist markets arose. These institutions persist despite their failure to respond to the challenges of the Anthropocene, foremost among them a rapidly changing climate. The pathological trajectories of these institutions need to be disrupted by ecological reflexivity: the questioning of core socioeconomic commitments while listening and responding effectively to signals from the Earth system.

See also: Politics and the Anthropocene, by Duncan Kelly (Polity Books 2019, 185 pages, $19.95 paperback)

Rethinking the Environment for the Anthropocene: Political Theory and Socionatural Relations in the New Geological Epoch, edited by Manuel Arias-Maldonado and Zev Trachtenberg (Routledge 2019, 224 pages, $44.95 paperback)

This book brings together current thinking about the Anthropocene in the field of Environmental Political Theory (EPT) to develop the idea of socionatural relations an idea that frames the environment in the Anthropocene in terms of the interconnected relationship between human beings and their surroundings. The chapters in the book show the diversity of points of view theorists take toward the Anthropocene, and socionatural relations more generally. All the chapters exemplify EPTs self-conscious effort to provide normative interpretations that are responsive to scientific accounts. Rethinking the Environment for the Anthropocene will help readers interested in the Anthropocene from any disciplinary perspective develop a critical understanding of its political meanings.

A Billion Black Anthropocenes or None, by Kathryn Yusoff (University of Minnesota Press 2019, 99 pages, $7.95 paperback)

No geology is neutral, writes Kathryn Yusoff. Tracing the color line of the Anthropocene, A Billion Black Anthropocenes or None examines how the grammar of geology is foundational to establishing the extractive economies of subjective life and the Earth under colonialism and slavery. Yusoff initiates a transdisciplinary conversation between feminist black theory, geography, and the Earth sciences, addressing the politics of the Anthropocene within the context of race, materiality, deep time, and the afterlives of geology. Part of the presss Forerunners series, A Billion Black Anthropocenes or None draws on the intense thinking, change, and speculation of contemporary scholarship.

See also: Anthropocene Feminism, edited by Richard Grusin (University of Minnesota Press 2017, 256 pages, $28.00 paperback)

Infrastructure, Environment, and Life in the Anthropocene, edited by Kregg Hetherington (Duke University Press 2019, 312 pages, $27.99)

Infrastructure, Environment, and Life in the Anthropocene explores life in the age of climate change through a series of infrastructural puzzles sites at which it has become impossible to disentangle the natural from the built environment. With topics ranging from breakwaters built of oysters, underground rivers made by leaky pipes, and architecture gone weedy to neighborhoods partially submerged by rising tides, the contributors explore situations that destabilize the concepts we once relied on to address environmental challenges. They take up the challenge that the Anthropocene poses both to life on the planet and to our social-scientific understanding of it by showing how past conceptions of environment and progress have become unmoored and what this means for how we imagine the future.

Sustainability in the Anthropocene: Philosophical Essays on Renewable Technologies, edited by Roisin Lally (Rowman & Littlefield 2019, 250 pages, $95.00)

We are facing an environmental crisis that some say is ushering a new geological epoch, the Anthropocene. In the face of this crisis it has become clear that we need a more sustainable culture. Sustainability, however, is a contested word, and it carries with it, often implicitly and unacknowledged, deep philosophical claims that are entangled with all kinds of assumptions and power relations, some of them very problematic. This book attempts to set this urgent goal of sustainability free from its more reductive and harmful interpretations and to thereby apply a more thoughtful environmental ethics to current and emerging technologies, particularly those involving reproduction and the harnessing of energy that dominate our elemental relations to sun and air, wind and water, earth and forest.

Visualizing Posthuman Conservation in the Age of the Anthropocene, by Amy D. Propen (Ohio State University Press 2018/2019, 224 pages, $29.95 paperback)

How do we understand the lives of nonhuman animals and our relationships with them? And what does it mean to practice conservation in the Anthropocene? Environmental Studies scholar Amy D. Propen seeks to answer these questions in Visualizing Posthuman Conservation in the Age of the Anthropocene. Through case studies in which visual technologies and science play a prominent role in arguments to protect threatened marine species for example, photographs showing the impact of ocean plastics on vulnerable sea birds Propen advances a notion of conservation that decenters the human enough to consider ideas about the material world from the vantage point of the nonhuman animal. Thereby Propen shows how interdisciplinary ways of knowing can shape and illuminate our various lived and embodied experiences.

See also: Thinking about Animals in the Age of the Anthropocene, edited by Morten Tonnessen, Kristin Armstrong Oma, and Silver Rattasepp (Rowman & Littlefield 2016, 272 pages, $39.95 paperback)

Searching for the Anthropocene: A Journey Into the Environmental Humanities, by Christopher Schaberg (Bloomsbury Books 2019, 224 pages, $24.95 paperback)

We live in a time of rampant consumerism and irresponsible disregard for the natural world. Still, we strive to find authentic interactions, something to counter the feeling of looming doom in which humans are inherently implicated, often searching for these in literature and art. The debates around the Anthropocene are in one sense an effort to reveal and work through these tensions. Developing a wide-angle approach to environmental studies, and blending personal narrative, cultural criticism, and environmental thought, Searching for the Anthropocene offers fresh ways to ponder literature and the humanities side-by-side with current conditions of ecological urgency, existential crisis, and social unrest.

Inhospitable World: Cinema in the Time of the Anthropocene, by Jennifer Fay (Oxford University Press 2018, 272 pages, $31.95 paperback)

Film, like the Anthropocene, is a product of the industrial revolution, but it arises out of a desire to preserve life and master time and space. Filmmaking stages the process by which worlds and weather come into being and meaning. Whereas standard ecological criticism attends to the environmental crisis as an unraveling of our natural state, Inhospitable World looks to film (from Buster Keaton, to Jia Zhangke, to films of atomic testing and early polar exploration) to consider how it reflects upon the creation and destruction of human environments. What are the implications of ecological inhospitality? As an art form, film enjoys a unique relationship to the material, elemental world it captures and produces. Through it, we may appreciate the ambitions to design an unhomely planet that may no longer accommodate us.

Anthropocene, by Edward Burtynsky, Jennifer Baichwal, and Nicholas de Pencier (Goose Lane Editions, 2018, 256 pages, $35.00)

In photographs that are both stunning and disconcerting, Edward Burtynsky, Jennifer Baichwal, and Nicholas de Pencier document species extinction (the burning of elephant tusks to disrupt the illegal trade of ivory), technofossils (swathes of discarded plastic forming geological layers), and terraforming (mines and industrial agriculture). The book also features a range of essays by artists, curators, and scientists, some part of an international group of scientists who have proposed that the Earth is now entering a new era of geological time where human activity is the driving force behind environmental and geological change i.e. the Anthropocene. Thus the book brings contemporary art into conversation with environmental science and anthropology on a topic that urgently affects all of us.

See also: Art, Theory, and Practice in the Anthropocene, edited by Julie Reiss (Vernon Press 2018, 174 pages, $36.00 paperback).

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Books about life in the Anthropocene - Yale Climate Connections

Video: In 40 years, babies could be made in the lab from skin cells – Genetic Literacy Project

The birds and the bees as we know them are changing. A new process called in vitro gametogenesis (IVG) is currently being developed, and if successful, it will completely transform the way humans think about reproduction.

In 20 to 40 years, people will still have sex. But when they want to make babies, theyll go to a lab, predicts Stanford University Professor Henry T. Greely. Its also the premise of his book The End of Sex and the Future of Human Reproduction.

The process of IVG creates sperm and egg cells in a lab from just about any adult cell. IVG uses skin or blood cells to reverse engineer a special type of cells calledinduced pluripotent stem cells(iPSCs).

IVG could eliminate the need for egg and sperm donors. With IVG, post-menopausal women could generate viable eggs. Same-sex couples could make a biological family. Virtually anyone with skin would have the ability to produce eggs or sperm.

Although 40 years might seem a lifetime away, theres a lot to figure out before we can safely, ethically, and responsibly add in vitro gametogenesis to our list of fertility treatment options.

Read full, original post: IVG: Making Babies From Skin Cells

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Video: In 40 years, babies could be made in the lab from skin cells - Genetic Literacy Project

The Troubling Ideals at the Heart of Abortion Rights – The Atlantic

Behind this logic is a kind of nontraditional, sociological rationale undergirding stare decisisthe legal principle of deferring to precedent. But the Casey plurality is also paying tribute to a long-popular argument among pro-abortion-rights legal thinkers: Abortion rights are necessary for womens equality. Indeed, for Justice Ruth Bader Ginsburg and the cadre of other like-minded legal thinkers, the right to abortion, currently based in substantive due process, would be better secured by the Equal Protection Clause of the Fourteenth Amendmentor, better still, the long-proposed Equal Rights Amendment to the U.S. Constitution. Justice Ginsburg, who defended abortion rights as equality rights in scholarship in the 1980s, more recently argued in her dissent in Gonsales v. Carhart that a constitutionally protected right to abortion is even necessary for womens equal citizenship stature.

Equality arguments for abortion rights have become so pervasive in law and politics that its easy to overlook just what is being claimed, and how very different this idea of equality is from that of those who first advocated for womens full legal, political, and social equality in this country.

Caitlin Flanagan: The dishonesty of the abortion debate

Consider, as one striking example, Victoria Woodhull, a leading suffragist and radical, and the first woman to run for president of the United States, nominated by the Equal Rights Party in 1872. With her peers in the 19th-century womens movement, she asserted, among a host of other rights, the right to be free of the common-law sexual prerogative that husbands then enjoyed over their wives. Understanding the asymmetrical consequences of sexual intercourse for women, Woodhull anticipated a time when woman rises from sexual slavery to sexual freedom into theownership and control of her sexual organs, and man is obliged to respect this freedom.

But owning and controlling ones body did not extend, for Woodhull and other advocates of voluntary motherhood, to doing what one willed with the body of another. Rather, these women sought sovereignty over their own bodies in part because they could claim no legitimate authority to engage, in Woodhulls words, in antenatal murder of undesired children. An outspoken advocate of constitutional equality for women, Woodhull also championed the rights of childrenrights that begin while yet they remain the fetus. In 1870, she wrote:

Many women who would be shocked at the very thought of killing their children after birth, deliberately destroy them previously. If there is any difference in the actual crime we should be glad to have those who practice the latter, point it out. The truth of the matter is that it is just as much a murder to destroy life in its embryonic condition, as it is to destroy it after the fully developed form is attained, for it is the self-same life that is taken.

Nearly 100 years later the arguments shifted, and womens-equality advocates began making arguments in favor of abortion rights. In 1969, in a first-of-its-kind legal brief, attorneys for 300 women challenged New York States thenrelatively restrictive abortion law. The attorneys in Abramowicz v. Lefkowitz rightly brought attention to the same stubborn reproductive asymmetries to which advocates of voluntary motherhood had sought to respond. But rather than call men to join women at a high standard of mutual responsibility and care, as prior generations of womens-rights advocates had done, the attorneys argued for a different kind of sexual equality. Because the man who shares responsibility for her pregnancy can and often does just walk away, the plaintiff's brief maintained that the woman ought to enjoy that same freedomthrough abortion. As the Harvard law professor Laurence Tribe would articulate the concept two decades later, While men retain the right to sexual and reproductive autonomy, restrictions on abortion deny that autonomy to women.

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Rewriting Our Genes Is Easier Than Ever. That Doesn’t Mean We Should Do It – WBUR

Gene-editing technologies have huge potential to alleviate human suffering. But, like all very powerful technologies, they also carry enormous risks if used improperly.

In November 2018, a team of scientists in China led by Dr. He Jiankui revealed shocking news at a conference: hed used CRISPR-Cas9 (often referred to as just CRISPR) to edit the genes of three embryos. Two of the embryos were successfully implanted in a surrogate, resulting in twin girls. Now known only as Nana and Lulu their identities protected in scientific version of the witness protection program Dr. He said hed used CRISPR to immunize the embryos to HIV. But hed acted against worldwide guidelines and regulations to do so. Those regulations prohibited germline edits, or genetic edits that are heritable to the edited organisms future offspring. (Dr. He and his collaborators were recently sentenced by a court in Shenzhen to three years in prison for conducting "illegal medical practices.")

Lets back up.

Gene editing is what it sounds like: modifying an organisms genes. The technology has a massive range of applications, and those applications carry different degrees of risk, depending on the kinds of cells edited.

Maybe you remember the distinction of somatic versus non-somatic cells from biology? If not, heres a refresher: its the difference between cells involved directly in reproduction (non-somatic) and cells not involved in reproduction (somatic). Most of your cells are somatic: your eyes, your lungs, your heart. For non-somatic, think sperm, eggs, embryos, stem cells: the cells directly used to create offspring. The difference is relevant because genetic modifications to reproductive (non-somatic) cells get passed on to the descendants of those organisms.

In essence, if you edit an organisms somatic cells (kidneys, blood, etc), that edit dies when the organism does. If you edit non-somatic cells, and the organism reproduces, its offsprings reproductive cells will have the same edit, which will be passed on and on, as long as the edited organisms genetic line keeps reproducing.

The results of Dr. He's genetic edits to embryos demonstrated the reasons for the ban on human germline editing: he might have inadvertently made unintended edits to the embryos other genes. His rogue experiments consequences might have significant adverse effects for Nana and Lulu, whose germline, or non-somatic genes, he edited.

And CRISPRs no longer the only gene-editing game in town. There was news last fall of a new gene-editing technology called "Prime-Editing." The developers claim its more precise than CRISPR.

The majority of the scientific community continues to agree on a moratorium on human germline editing. But that word, moratorium, has a temporary connotation, and some scientists are likely to agitate for human germline editing with this new technology, despite the widely acknowledged disaster of Dr. He's first foray. Some might argue that this more precise method of gene editing would be safe to use for human germline edits.

That argument pushes us towards a risk we shouldnt take. Prime-Editing is more precise than CRISPR, but that doesnt make it safe for this purpose. If germline gene editing goes wrong, theres no ethically sound way to stop the resulting domino effect.

... there is no precedent -- nor should there be -- for preventing a person who hasn't even been born yet from reproducing as an adult

Gone wrong, germline gene editing has the potential to do widespread damage. Consider the recent finding that all living human beings descended from one woman who lived in the area we now call Botswana. Scientists have referred to this common ancestor as Mitochondrial Eve. Take her as an example an extreme, but real, example of the potential reach of one individuals genes.

Editing an embryos germline genes means that youre altering the genetic code of that person, for life and, if that individual has a baby, they may pass on those altered genes to that baby.

If Nana or Lulu have children, theyll pass on the germline edits Dr. He made both the intended and the unintended. When they come of age, Nana and Lulu will have to have a version of the where babies come from? talk that no human being has ever before experienced, or should have to.

The only way to prevent the future transmission of germline edits is to prevent the person whose genes have been edited from reproducing. Nana and Lulu couldnt have possibly consented to that as a condition of the experiment, because they werent alive when the experiment was performed. Limiting their reproductive possibilities in that way would approach eugenics.

A more precise technology might be better, but it still isnt perfectly precise.

Internal review boards, the ethics committees that review proposed scientific research, make many fraught calculations, but there is no precedent nor should there be for preventing a person who hasn't even been born yet from reproducing as an adult. Its the internal review boards' job to contain possible problems, but they can't contain this problem without causing another.

The if we can do it, we will argument doesnt hold with what todays technology makes us capable of. We shouldnt follow the hinge of every if, then to an unknown, potentially catastrophic outcome. We have to set some hard limits on what well do with the technologies we develop.

This is one such example.

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Rewriting Our Genes Is Easier Than Ever. That Doesn't Mean We Should Do It - WBUR

Yes, Killer Whales Benefit From Grandmotherly Love Too – The New York Times

Parents, at least the human sort, know the benefits of having a grandmother close by: the extra help with child care, the reassuring advice borne from years of experience. In evolutionary biology, scientists call this the grandmother effect, and have hypothesized its one of the reasons humans live so long.

Now, a new study suggests that the effect isnt limited to humans, and that killer whales also benefit from having grandmothers around. The study, published Monday in the Proceedings of the National Academy of Sciences, found that grandmother killer whales helped improve their grandcalves chances of survival, particularly when food was scarce.

The findings may shed light on an enduring mystery: why some whale species live for years after they go through menopause and stop reproducing. The study showed that, by stopping reproduction, grandmother killer whales avoided conflict with their reproducing offspring and helped their grandcalves find enough to eat when salmon stocks dwindled.

Having a living grandmother improves your survival; youre less likely to die when shes alive than in the years following her death, Stuart Nattrass, the studys lead author, and a researcher at the University of Hull, in Britain, wrote in an email.

Weve known this is true of humans and a few other animals that dont have menopause, like African elephants, for a while, and had a strong inkling that it was also true in these resident killer whales, he wrote.

He and other researchers said the findings could be important for orca conservation, suggesting its just as vital to protect older, postmenopausal females as it is younger females of breeding age and their offspring.

Worldwide, there are an estimated 50,000 killer whales, or orcas. But several populations have declined in recent decades, and some have become endangered, according to the National Oceanic and Atmospheric Administration.

To assess the survival rates of killer whales in lean years, the study examined census data for two populations, off Washington State and British Columbia, as well as annual catch numbers from chinook salmon fisheries in the Pacific Northwest.

The population off Washington State has been endangered since 2005, and is now critically endangered. It has just 73 orcas and four grandmothers, according to Deborah Giles, a killer whale researcher at the University of Washingtons Center for Conservation Biology. Dr. Giles, who was not involved in the study, called that scarcity of grandmothers startling and scary.

Orca matriarchs, she said, play a critical role in the species survival by guiding their families to fish when stocks are low and caring for the young while the mothers of breeding age hunt.

Its part of what makes killer whales amazing animals, Dr. Giles said. They are these large-bodied, long-lived apex predators, and a lot of the life span for post-reproductive females is spent caring for, and being there with, their families. We dont see that as readily in other species.

Female killer whales typically start reproducing in their teens and stop in their 30s or 40s. Yet they can live well into their 80s and 90s, posing the question for scientists of why this postmenopausal stage of life has evolved. Why stop breeding if the goal is to pass on your genes?

Dr. Nattrass said the study could point to some answers. It found that postmenopausal killer whales provided the biggest boost to their grandcalves chances of survival, beyond that provided by grandmother killer whales that were still breeding.

This is a particularly striking example of a case where there might be a fitness benefit to not breeding yourself you can better help your grandkids if youre not preoccupied with a baby of your own, he wrote.

Dr. Nattrass said postmenopausal killer whales are able to guide their families to salmon when its scarce, using stores of ecological knowledge gained over decades of life experience. Without that knowledge, Dr. Nattrass said, the grandcalves could die.

As salmon stocks continue to fall, the presence of these grandmothers becomes more and more important, Dr. Nattrass wrote. But there is going to be a point where that knowledge isnt enough. We really need to boost salmon stocks if these grandmothers are going to be able to help their families.

Dr. Giles recalled one striking instance of this grandmotherly help: an aerial photo, taken in 2016, that showed a killer whale known as J2, estimated to be at least 75 and possibly older than 100, catching and sharing salmon with a recently orphaned youngster, presumed to be her granddaughter. The grandmother was feeding the youngster even as she was getting thinner and thinner toward the end of her life, Dr. Giles said.

Heres this old, old female still trying to make sure her family members have enough food to eat, Dr. Giles said. She could have eaten that fish in one bite. But she didnt.

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Yes, Killer Whales Benefit From Grandmotherly Love Too - The New York Times

Microphysiological systems: advancing drug and biological therapies discovery – SciTech Europa

How many of the thousands of newly discovered molecules finally become drugs which effectively cure patients? Unfortunately, only a very low percentage (recently quantified around 12%). Why do so many candidate drugs fail before entering the market, although they show promising results at a research level? A recent paper indicates a lack of specific drug efficacy as the primary cause of trial failure in late phase development, failures that can be reduced by a more efficient screening of candidate drugs in early phases.

However, current 2D in vitro strategies, mostly based on cell lines cultured on 2D rigid substrates, represent the cheapest and easiest drug screening tool, but with major drawbacks as low-precision and un-natural environments. In vivo experimentation provides higher systemic physiological relevance, although associated to high running costs, increasing ethical issues and limited analytical depth. Moreover, animal models have been increasingly questioned about their power to faithfully reproduce human biological mechanisms.

Thus, alternative models better predicting the outcomes of new molecules in patients are desperately needed. Recently, innovative techniques such as microfluidics and tissue engineering have been emerging, aiming at reproducing the complex architecture and function of native human tissues. So-called organs-on-a-chip or microphysiological systems have recently been defined as microfabricated cell culture devices designed to model the functional units of human organs in vitro, thus representing an ideal platform for improving the predictability of drugs and biological therapies efficacy and safety in humans.

Our group believes that microphysiological systems hold the key to next generation health solutions. Following our 10+ years experience and specialisation in this area, we have emerged in the development of microphysiological systems in the musculoskeletal field, for platforms to study physio-pathological mechanisms and to perform reliable screening and testing of drugs for diagnostic and therapeutic aims.

In particular, these systems are used for currently uncurable bone diseases such as bone tumours and metastases, but also for pathological conditions of muscle tissue such as fibrosis, disabling pathologies (such as osteoarthritis), as well as ageing and metabolic diseases of the musculoskeletal system. This is achieved by reproducing human tissue districts focusing on high-fidelity biomimicking models through human multi-cellular and architecturally accurate models (i.e. whole joint model including all parts as bone, cartilage, synovium, vascular, immune in a single model).

The first example of a microfluidic, vascularised, human bone model for the study of bone metastatic invasion has been published on Biomaterials in 2014 and highlighted in The Economist journal. With this work, in collaboration with prof R Kamm from MIT, we were able to monitor the invasion of breast cancer cells in a bone-like matrix and the formation of micro-metastases in real time. In a subsequent work, we reproduced organotypic metastases from breast cancer, comparing engineered bone-like and muscle-like environments, and demonstrating the secretion of molecules in the muscle environment able to counteract tumour invasion.

To better mimic the metastatic process, blood and immune cells were also included in our recent models, demonstrating that the presence of blood cells (particularly platelet) increase metastatisation and that a drug used as antiaggregant clinical therapy can also decrease cancer invasion.

Microfluidic multi-tissue models have been also designed to investigate diseases affecting the joints, such as osteoarthritis.

A multichannel device, including the tissues of the native joint, as a cartilage compartment, separated from a compartment embedding synovial fibroblasts by a channel containing synovial fluid has been developed. The device mimicked the inflammatory processes at the basis of osteoarthritis and is being exploited to evaluate potential biological therapies, such as the injection of stem cells in the joint.

Microfluidics is a powerful technology however it comes with its own drawbacks too as the microenvironment into a microfluidic chip is not properly 3D, being able to host tissues with a thickness of just few cells (between 10 and 15), and thus also a scarce availability of biological material which makes it difficult to apply standard analytical techniques.

To overcome these limitations, in our lab we are exploiting both Micro- and Bio- fabrication techniques to generate miniaturised multicellular microphysiological systems, bigger and more user friendly than microfluidic ones which allow you to more accurately reproduce the 3D microarchitecture of native musculoskeletal tissues.

In 2016 we generated a mm-scale construct, embedding osteoblasts, osteoclasts, vascular cells and calcium nanoparticles, to recreate the mineral part of the bone. This represented the first example of a bone-remodelling microscale model able to reproduce the balanced deposition and resorption of minerals by bone cells, recently further improved with the addition of macrophages. To test the potential of the device as a drug screening platform, we added breast cancer cells in the bone-like matrix and effects of different drugs have recently been tested. The model showed a significantly better reproduction of cancer cell resistance to drugs as compared to standard in vitro models.

Beside bone, also a hierarchical microscale model of skeletal muscle has been described with multiple human muscle fibres engineered in a 3D gel. Here we showed for the first time the formation of the typical fibroblast layer surrounding each fibre intertwined with a microvascular network. Fibroblasts isolated from dystrophic patients and inserted in our model naturally exerted the traditional onset of fibrosis characteristics as compared to standard models requiring external induction for such behaviour.

To summarise, microphysiological systems represent the leading approach to achieve more reliable preclinical testing platforms for the quantification of drug efficacy, as compared to standard 2D models. However, further challenges lie ahead for their widespread use. In basic and translational research towards clinical application, a better understanding of pathophysiological mechanisms is mandatory.

Thus, faithful reproduction of complex native-like microenvironments should be achieved, including appropriate physical stimuli, whereby the exploitation of advanced microfabrication techniques can be of help towards this goal. Biofabrication of functional units of human tissues and organs is fundamental also for pharma companies, along with relevant automation and ease of use, to achieve more reliable readouts of novel drugs and highly predictive tests for biological therapies.

Depending on its final application, the complexity level of 3D in vitro models should be tailored to sufficiently improve relevance but without unnecessary additions and increasing costs. Anyhow, considering the multiple issues involved in the development of microphysiological systems, multidisciplinary expertise and knowhow in biological and bioengineering fields are mandatory, and fostering of translational researchers training will be needed to guarantee the emergence of such next generation systems.

Lastly, the huge amount of heterogenous data originating from such complex models need to be analysed with systems biology techniques, based on machine learning algorithms and similarly advanced techniques gathered from big data management. Fuelling research in these fields can help the research community in achieving better models of human organs, thus leading to drugs more effectively impacting patient care.

Matteo MorettiHead Regenerative Medicine Technologies LabUnit di Ortopedia e Traumatologia, Ente Ospedaliero CantonaleLugano (CH)+41(0)918117076Matteo.moretti@eoc.chhttps://www.eoc.ch/

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Microphysiological systems: advancing drug and biological therapies discovery - SciTech Europa

This Irresponsible Sex Ed Curriculum Is Being Taught in Texas School Districts – Friendly Atheist – Patheos

In case youre wondering what bad sex education looks like in some school districts, look no further than than Texas where eight school districts, including the Leander Independent School District (LISD), outsources its sex ed curriculum to a group called Austin LifeGuard (ALG).

ALG is run by Austin LifeCare now using the more deceptive name The Source a self-described anti-abortion crisis pregnancy center with Christian connections. Naturally, theyre less interested in educating students about making safe decisions when having sex, choosing instead to scare them away from sex altogether. That option never works. Which means students are left to fend for themselves when they finally choose to do anything physical.

April S. Kelley writes about the problem for the Hill Country News.

In the 7th grade curriculum, an activity involving Skittles is used to demonstrate how easily sexually transmitted infections are spread from person to person.

The Houston Chronicle published an article in September, and quoted a former LISD student. She shared how the Skittles activity gave her the insinuation of the more people you have sex with, the dirtier you are.

The course packet said each student would be given one Skittle. Students with yellow Skittles would be told to keep their Skittles, while anyone with any other color would trade with as many classmates as possible. After doing so, the students would be asked if they would eat those Skittles. The yellow Skittles represent abstinence.

The executive director of ALG didnt deny they promoted this activity. He just said the focus wasnt about whos dirty. It was meant to teach kids about exposure to sexually transmitted diseases. But the implication in the activity is obvious.

They also mislead students about the effective of condoms. ALG tells students that condoms are only 87% effective, which is a number that includes people who misuse them. Rather than teach kids how to use them properly, though something that the government says has a 98% success rate they would rather mislead kids into thinking condoms are less effective than they really are.

It gets worse.

The 7th grade curriculum also shows a lack of balance between male and female sexuality. The curriculum, which is taught co-ed, shows a diagram of both male and female anatomy to explain human reproduction. In the female anatomy, however, there was one part missing the clitoris.

in the female curriculum, there is no mention of arousal, sexual feelings or of those things being a normal part of female puberty.

Then there are the commercials. Like this one promoting a I Heart Pants campaign because if youre wearing pants, youll never have sex. (These people have clearly never met teenagers)

Another commercial suggests that sexually active teens are not capable of getting good grades or acceptance into top colleges.

Maybe the most disturbing thing about all this is that the LISD has been working with this sex negative group for 13 years; the most recent three-year contract was signed in 2018 at a cost of $35,000 (a year, presumably).

Its yet another example of a conservative Christian organization sneaking its way into public schools with the goal of making students less informed, more at risk, and more in need of outside help down the road. Theyre hurting kids. And that wont change unless students and parents pressure the school board into making decisions that benefit kids instead of appeasing right-wing Christian groups.

(Thanks to @smileysatanist for the link)

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This Irresponsible Sex Ed Curriculum Is Being Taught in Texas School Districts - Friendly Atheist - Patheos

From ’embryo glue’ to ‘assisted hatching’: Do these expensive IVF add-ons actually work? – The Daily Briefing

As demand for in vitro fertilization (IVF) has grown, fertility clinics have developed supplementary procedures, or "add-ons," that are purported to increase the odds of successbut there's little evidence these add-ons actually work, Sharon Begley reports for STAT News.

Cheat sheets: Evidence-based medicine 101

One add-on that received closer scrutiny earlier this year is "endometrial scratching," Begley reports. The theory behind the procedure is that using a pipette to scratch the endometrium could trigger a hormonal response to make the tissue more receptive to the implantation of an embryo.

Fertility practices started using the procedure about 20 years ago, after doctors in Israel observed that women who underwent a biopsy of their uterine lining seemed to have higher pregnancy rates.

Since then, a handful of case reports showed that some patients who underwent the procedure gave birth at a higher rate than those who didn't. But a large randomized controlled study of 1,364 women published in the New England Journal of Medicine earlier this year found that endometrial scratching had no effect on live birth rates.

"Assisted hatching" is another common IVF add-on that has been shown to have little effect on birth rates, Begley reports. In this procedure, embryologists use acid, lasers, or other tools to poke a hole in a woman's zona pellucida, which covers the ova, to increase the chances of embryo fertilization.

But an analysis in 2016 found that, while the procedure may increase pregnancy rates, it had no effect on live birth rates because it came with higher miscarriage rates.

Other add-ons have a bit more evidence behind them, Begley reports. For example, research on "artificial egg activation," in which clinicians cover fertilized eggs in chemicals called calcium ionophores to induce the embryo development process, has shown that it may improve fertilization rates once sperm is injected into an egg. However, other research has found the procedure has no benefit, Begley reports.

Similarly, some clinics add hyaluronan, known as "embryo glue," to a lab dish to increase implantation chances. The practice has been found to increase the chances of live birth by about 10% in the United States, which translates to 39% of IVF cycles resulting in a live birth, Begley reports.

Meanwhile, some IVF add-ons have been shown to be counterproductive and may even increase the risk of miscarriage, Begley reports. For example a 2019 analysis, found that time-lapse systems to monitor IVF embryos had miscarriage rate of 4% to 14%, compared to 4% through traditional incubation.

Moreover, an add-on called preimplantation genetic testing for aneuploidy (PGT-A) "indisputably hurt women's chances of giving birth," Begley writes. In this add-on, embryos are tested for aneuploidy, a chromosomal anomaly, and those that show an anomaly are not implanted and are typically discharged.

However, a large randomized controlled trial published last year by the European Society of Human Reproduction and Embryology said that PGT-A, which usually costs around $5,000, "makes no difference to live birth rates," meaning that embryos discarded through PGT-A potentially could have been viable.

According to Jack Wilkinson, a biostatistician at the University of Manchester in England, who led one of four analyses on IVF add-ons published in the journal Fertility and Sterility, there is "at best, extremely weak or contradictory evidence of benefit" for IVF add-ons. "At worst, there is good evidence that some of the add-ons lower the chance" of conception through IVF.

Lax regulation of fertility clinics could be one reason why add-ons are easily incorporated into a treatment plan, Begley reports. FDA requires a safety and efficacy assessment of procedures that manipulate human cells "more than minimally," but fertility procedures do not rise to that standard. That means FDA doesn't require any proof that IVF procedures benefit patients, Begley reports.

Pamela Mahoney Tsigdinos, co-author of Wilkinson's paper and a former IVF patient, said, "Patients are given the impression that the procedures have been studied and shown to be effective. But in most cases, they haven't been. You're on your own at a time when you're in no position to be objective."

Meanwhile, Alan Penzias, a Massachusetts-based fertility doctor and chair of the American Society for Reproductive Medicine practice committee, said doctors use add-ons typically when the core procedure doesn't work. He noted, "Patients and providers have the same interests. A pregnancy with a healthy singleton baby as soon as possible."

He continued, "Sometimes, when you're down to your last hurrah" with a patient who doesn't have much money, time, or emotional or physical strength left for IVF, "you want to throw everything you've got at it" (Begley, STAT News, 11/5).

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From 'embryo glue' to 'assisted hatching': Do these expensive IVF add-ons actually work? - The Daily Briefing

Anna Louie Sussman: Is this the end of babies? – Salt Lake Tribune

In the fall of 2015, a rash of posters appeared around Copenhagen. One, in pink letters laid over an image of chicken eggs, asked, Have you counted your eggs today? A second a blue-tinted close-up of human sperm inquired, Do they swim too slow?

The posters, part of a campaign funded by the city to remind young Danes of the quiet ticking of their biological clocks, were not universally appreciated. They drew criticism for equating women with breeding farm animals. The timing, too, was clumsy: For some, encouraging Danes to make more babies while television news programs showed Syrian refugees trudging through Europe carried an inadvertent whiff of ugly nativism.

Dr. Soren Ziebe, former chairman of the Danish Fertility Society and one of the brains behind the campaign, believes the criticism was worth weathering. As the head of Denmarks largest public fertility clinic, Dr. Ziebe thinks these kinds of messages, fraught as they are, are needed. Denmarks fertility rate has been below replacement level that is, the level needed to maintain a stable population for decades. And as Dr. Ziebe points out, the decline is not solely the result of more people deliberately choosing childlessness: Many of his patients are older couples and single women who want a family, but may have waited until too late.

But the campaign also notably failed to land with some of its prime targets, including Dr. Ziebes own college-age daughter. After she and several classmates at Copenhagen University interviewed him for a project on the campaign, Dr. Ziebe sought answers of his own.

I asked them, Now, you know you have gained a lot of information, a lot of knowledge. What are you going to change in your own personal lives? he said. He shook his head. The answer was Nothing. Nothing!

If any country should be stocked with babies, it is Denmark. The country is one of the wealthiest in Europe. New parents enjoy 12 months paid family leave and highly subsidized day care. Women under 40 can get state-funded in vitro fertilization. But Denmarks fertility rate, at 1.7 births per woman, is roughly on par with that of the United States. A reproductive malaise has settled over this otherwise happy land.

Its not just Danes. Fertility rates have been dropping precipitously around the world for decades in middle-income countries, in some low-income countries, but perhaps most markedly, in rich ones.

Declining fertility typically accompanies the spread of economic development, and it is not necessarily a bad thing. At its best, it reflects better educational and career opportunities for women, increasing acceptance of the choice to be child-free, and rising standards of living.

At its worst, though, it reflects a profound failure: of employers and governments to make parenting and work compatible; of our collective ability to solve the climate crisis so that children seem a rational prospect; of our increasingly unequal global economy. In these instances, having fewer children is less a choice than the poignant consequence of a set of unsavory circumstances.

Decades of survey data show that peoples stated preferences have shifted toward smaller families. But they also show that in country after country, actual fertility has fallen faster than notions of ideal family size. In the United States, the gap between how many children people want and how many they have has widened to a 40-year high. In a report covering 28 countries in the Organization for Economic Cooperation and Development, women reported an average desired family size of 2.3 children in 2016, and men wished for 2.2. But few hit their target. Something is stopping us from creating the families we claim to want. But what?

There are as many answers to this question as there are people choosing whether to reproduce. At the national level, what demographers call underachieving fertility finds explanations ranging from the glaring absence of family-friendly policies in the United States to gender inequality in South Korea to high youth unemployment across Southern Europe. It has prompted concerns about public finances and work force stability and, in some cases, contributed to rising xenophobia.

But these all miss the bigger picture.

Our current version of global capitalism one from which few countries and individuals are able to opt out has generated shocking wealth for some, and precarity for many more. These economic conditions generate social conditions inimical to starting families: Our workweeks are longer and our wages lower, leaving us less time and money to meet, court and fall in love. Our increasingly winner-take-all economies require that children get intensive parenting and costly educations, creating rising anxiety around what sort of life a would-be parent might provide. A lifetime of messaging directs us toward other pursuits instead: education, work, travel.

These economic and social dynamics combine with the degeneration of our environment in ways that hardly encourage childbearing: Chemicals and pollutants seep into our bodies, disrupting our endocrine systems. On any given day, it seems that some part of the inhabited world is either on fire or underwater.

To worry about falling birthrates because they threaten social security systems or future work force strength is to miss the point; they are a symptom of something much more pervasive.

It seems clear that what we have come to think of as late capitalism that is, not just the economic system, but all its attendant inequalities, indignities, opportunities and absurdities has become hostile to reproduction. Around the world, economic, social and environmental conditions function as a diffuse, barely perceptible contraceptive. And yes, it is even happening in Denmark.

Danes dont face the horrors of American student debt, debilitating medical bills or lack of paid family leave. College is free. Income inequality is low. In short, many of the factors that cause young Americans to delay having families simply arent present.

Even so, many Danes find themselves contending with the spiritual maladies that accompany late capitalism even in wealthy, egalitarian countries. With their basic needs met and an abundance of opportunities at their fingertips, Danes instead must grapple with the promise and pressure of seemingly limitless freedom, which can combine to make children an afterthought, or an unwelcome intrusion on a life that offers rewards and satisfactions of a different kind an engaging career, esoteric hobbies, exotic holidays.

Parents say that children are the most important thing in my life, said Dr. Ziebe. By contrast, those who havent tried it who cannot imagine the shifts in priorities it produces, nor fathom its rewards see parenting as an unwelcome responsibility. Young people say, Having children is the end of my life.

There are, to be sure, many people for whom not having children is a choice, and growing societal acceptance of voluntary childlessness is undoubtedly a step forward, especially for women. But the rising use of assisted reproductive technologies in Denmark and elsewhere (in Finland, for example, the share of children born via assisted reproduction has nearly doubled in a little more than a decade; in Denmark, it accounts for an estimated one in 10 births) suggests that the same people who see children as a hindrance often come to want them.

Kristine Marie Foss, a networking specialist and event manager, almost missed out on parenthood. A stylish woman with a warm smile, Ms. Foss, now 50, always dreamed of finding love, but none of her serious boyfriends lasted. She spent most of her 30s and 40s single; those were also the decades in which she worked as an interior designer, created several social networks (including one for singles, before it was cool to be single) and expanded and deepened her friendships.

It wasnt until she was 39 that she realized it might be time to start thinking seriously about a family. A routine visit to the gynecologist prompted an unexpected revelation: If I become 50 or 60 and I dont have kids, I know Im going to hate myself the rest of my life, said Ms. Foss, now the mother of a 9-year-old and 6-year-old via a sperm donor. Ms. Foss has joined the ranks of what Danes call solomor, or single mothers by choice, a cohort that has been growing since 2007, when the Danish government began covering IVF for single women.

There are those who have always sought to lay the blame for declining fertility, in some way, on women for their individual selfishness in eschewing motherhood, or for their embrace of feminisms expansion of womens roles. But the instinct to explore life without children is not restricted to women. In Denmark, one out of five men will never become a parent, a figure that is similar in the United States.

Anders Krarup is a 43-year-old software developer living in Copenhagen who recently rediscovered his love of fishing. Most weekends he drives to the Zealand coast, where he communes with the sea trout. When hes not working at his start-up, he meets friends for concerts. As for a family, hes not particularly interested.

Im feeling very content with my life at the moment, he told me.

Mads Tolderlund is a legal consultant who works outside of Copenhagen. At age 5, he was struck with wanderlust when he saw an advertisement for Uluru, or Ayers Rock, in Australia. He eventually resolved to visit every continent in his lifetime, and today, at 31, has just Antarctica to go. In his view, people have children either because they truly want them, because they fear the consequences of not having them, or because its the normal thing. None of those reasons apply to him.

I have so many other things that I want to do, he said.

Are all these options not precisely what capitalism promised us? We were told that equipped with the right schooling, work ethic and vision, we could have professional success and disposable income that we could use to become the most interesting, most cultured, most toned versions of ourselves. We learned that doing these things learning, working, creating, traveling was rewarding and important.

Trent MacNamara, an assistant professor of history at Texas A&M University, has been pondering human attitudes toward fertility and family for over a decade. Economic conditions, he notes, are only part of the picture. What may matter more are the little moral signals we send each other, he writes in a forthcoming essay, based on big ideas about dignity, identity, transcendence and meaning. Today, we have found different ways to make meaning, form identities and relate to transcendence.

In this context, he said, having children may appear to be no more than a quixotic lifestyle choice absent other social cues reinforcing the idea that parenting connects people to something uniquely dignified, worthwhile and transcendent. In a secular world in which a capitalist ethos extract, optimize, earn, achieve, grow prevails, those cues are increasingly difficult to notice. Where alternative value systems exist, however, babies can be plentiful. In the United States, for example, communities of Orthodox and Hasidic Jews, Mormons and Mennonites have birthrates higher than the national average.

Lyman Stone, an economist who studies population, points to two features of modern life that correlate with low fertility: rising workism a term popularized by the Atlantic writer Derek Thompson and declining religiosity. There is a desire for meaning-making in humans, Mr. Stone told me. Without religion, one way people seek external validation is through work, which, when it becomes a dominant cultural value, is inherently fertility reducing.

Denmark, he notes, is not a workaholic culture, but is highly secular. East Asia, where fertility rates are among the lowest in the world, is often both. In South Korea, for example, the government has introduced tax incentives for childbearing and expanded access to day care. But excessive workism and the persistence of traditional gender roles have combined to make parenting difficult, and especially unappealing for women, who take on a second shift at home.

The difference between life in tiny Denmark, with its generous social welfare system and its high marks for gender equality, and life in China, where social assistance is spotty and women face rampant discrimination, is vast. Yet both countries face fertility rates well below replacement levels.

If Denmark illustrates the ways that capitalist values of individualism and self-actualization can nonetheless take root in a country where its harshest effects have been blunted, China is an example of how those same values can sharpen into competition so cutthroat that parents speak of winning from the starting line, that is, equipping their children with advantages from the earliest possible age. (One scholar told me this can even encompass timing conception to help a child in school admissions.)

After decades of restricting most families to just one child, the government announced in 2015 that all couples were permitted to have two. Despite this, fertility has barely budged. Chinas fertility rate in 2018 was 1.6.

The Chinese government has long sought to engineer its population, reducing quantity in order to improve quality. These efforts are increasingly focused on what Susan Greenhalgh, a professor of Chinese society at Harvard, describes as cultivating global citizens through education, the means by which Chinese people and the nation as a whole can compete in the global economy.

By the 1980s, she said, child-rearing in China had become professionalized, shaped by the pronouncements of education, health and child psychology experts. Today, raising a quality child is not just a matter of keeping up with the latest child-rearing advice; its a commitment to spending whatever it takes.

These notions of the quality child, the quality person, got articulated in the language of the market, she said. It means, What can we buy for the kid? We need to buy a piano, we need to buy dance lessons, we need to buy an American experience.

Talking to young Chinese people who have benefited from their parents investments in them, I heard echoes of their Danish peers. For those with the right credentials, the past few decades have opened up opportunities their parents never imagined, making having children look burdensome by comparison.

I feel like I just got out of college, just started working, said Joyce Yuan, a 27-year-old Beijing-based interpreter, whose plans include earning an M.B.A. outside of China. I still think that Im at the very beginning of my life.

But Ms. Yuan and others were also quick to note Chinas harsh economic conditions, a factor that rarely, if ever, came up in Denmark. She cited, for instance, the high cost of urban living. Everything is super expensive, she said, and quality of life, especially in big cities, is extremely low.

The factors suppressing fertility in China are present throughout the country: In rural areas, where 41 percent of its nearly 1.4 billion citizens still live, there is little enthusiasm for second children, and policymakers can seemingly do even less about it. In Xuanwei Prefecture, after the central government announced in 2013 that couples in which one spouse was an only child could apply for permission to have a second baby, just 36 people sought such approval in the first three months in a region of around 1.25 million people. Local family planning officials blamed economic pressure on young couples for the low take-up, the authors of a study on China and fertility wrote.

In urban settings, the opportunities for education and enrichment are more abundant, and the sense of competition more intense. But Chinese couples everywhere are responsive to the pressures of the countrys hyper-capitalist economy, where setting a child down the right path could mean life-changing opportunities, while heading down the wrong one means insecurity and struggle.

As access to college has expanded, the value of a diploma is worth less than it once was. Competition for places in top schools has grown more brutal, and the need to invest heavily in a child from the start more imperative. For many mothers, arranging the details of a childs education, seen as the most critical channel for upgrading his or her quality, has almost become a full-time job, said Dr. Greenhalgh.

One Beijing resident, Li Youyou, 33, sees the stratified nature of reproduction in China playing out within her own circle. A wealthy friend with a high-earning husband is having her second child this year. Another, from a modest background, gave birth this summer; when Ms. Li asked her about a second, she said she could barely contemplate providing for this one. Ms. Li, who teaches English, was planning a visit to bring a gift for the baby. She wondered if she should just give money.

Ms. Li has no near-term plans for a family. She hopes instead to pursue a doctorate in linguistics, preferably in the United States.

Having a relationship is not my priority right now, she said. I more want to focus on my career.

My own experience as an American has been in some respects Danish, in others Chinese. I am one of the lucky ones: Thanks to scholarships, and my mothers tremendous sacrifices, I graduated from college without debt. Thus unencumbered, I spent most of my 20s working and studying overseas. Along the way, I got two master's degrees, and built a rewarding, if not especially remunerative, career. In my late 20s, I learned about egg freezing. It seemed like a secret weapon I could use to stave off the decision of if and when to have kids an absolution, of sorts, for spending years abroad and not searching terribly hard for a partner.

At 34, I finally underwent the procedure. Last year, I did another round. Ever since then, theres a number Ive been playing with as Ive wondered about whether and when I will use those eggs. According to my back-of-the envelope calculations, I should have $200,000 saved before having a child.

To be clear, I am fully aware that people far worse off than me have children all the time. I know that even the prospect of a pre-pregnancy savings target vaults me into the realm of tragicomic middle-class absurdity. I am resolutely not saying that if you dont have this (or any sum of) money, you should reconsider children.

Rather, this number is a hybrid an acknowledgment of the financial realities of single parenthood, but also the arithmetic crystallization of my anxieties around parenthood in our precarious era. To me, it demonstrates that even with my abundant privileges, it can still feel so risky, and on some days impossible, to bring a child into the world. And from the dozens of conversations Ive had in reporting this essay, its clear these anxieties are shaping the choices of many others, too.

Where did I get the $200,000 figure from? First, theres at least $40,000 for two rounds of IVF. (That I am contemplating this route also speaks to the obstacles of dating under late capitalism but thats a subject for a different article.) Thousands of dollars in hospital bills for a birth, provided its not a complicated one.

As a freelancer, I wouldnt be eligible for paid leave, so Id either need child care (easily $25,000 a year or more) until the child starts prekindergarten, or have enough saved to support us while Im not working. I could sell my studio apartment, but homeownership is a key means by which parents pay for college, and I am as terrified of relinquishing this asset as I am of launching a child into the job market sans higher education credentials. On some days, I tell myself Im being responsible by waiting. On other days, I wonder how this anxiety over my present might crowd out the future I envision.

The point is not really whether $200,000 is reasonable; it is that the very notion of attaching a dollar figure to an experience as momentous as parenthood is a sign of how much my mind-set has been warped by this system that leaves us each so very much on our own, able to avail ourselves of only what we can pay for.

For decades, people with as much good fortune as I have were relatively immune to these anxieties. But many of the difficulties that have long faced working-class women, and especially women of color, are trickling up. These women have worked multiple jobs without stability or benefits, and raised children in communities with underfunded schools or poisoned water; today, middle-class parents, too, are time-starved, squeezed out of good school districts, and anxious about plastic and pollution.

In the 1990s, black feminists, facing the conditions above, developed the analytical framework known as reproductive justice, an approach that goes beyond reproductive rights as they are usually understood access to abortion and contraceptives to encompass the right to have children humanely: to have children, not have children, and parent the children we have in safe and sustainable communities, as the collective SisterSong put it.

Reproductive justice was not always well understood or embraced by mainstream reproductive rights groups. (Loretta Ross, one of the founders of the movement, said an early focus group found people thought the term referred to seeking fairness for photocopiers.) But the trickling up of reproductive injustice could potentially give it broader traction. White America is now feeling the effects of neoliberalism capitalism that the rest of America has always felt, Ms. Ross said.

Are we prepared, though, for what it asks of us? Ms. Ross compared reproductive justice activism to parenting. When you parent, youve got to work on safe drinking water, and safe schools and a clean bedroom at the same time, she said. Peoples lives are holistic and interconnected. You cant pull on one thread without shaking up the whole thing. Seen in this light, incremental improvements like paid parental leave are only a partial fix for our current crisis, a handful of crumbs when our bodies and souls require a nourishing meal.

The solution, therefore, is not to compel a man like Anders Krarup to put aside his fishing and procreate, nor to dissuade Li Youyou from pursuing her Ph.D. Instead, we must recognize how their decisions take place in a broader context, shaped by interrelated factors that can be hard to discern.

The problem, to be clear, is not really one of population, a term that since its earliest use, according to the scholar Michelle Murphy, has been a profoundly objectifying and dehumanizing way to discuss human life. Hundreds of thousands of babies are born on this planet every day; people all over the world have shown they are willing to migrate to wealthier countries for jobs. Rather, the problem is the quiet human tragedies, born of preventable constraints an employers indifference, a belated realization, a poisoned body that make the wanted child impossible.

The crisis in reproduction lurks in the shadows, but is visible if you look for it. It shows up in each year that birthrates plumb a new low. Its in the persistent flow of studies linking infertility and poor birth outcomes to nearly every feature of modern life fast-food wrappers, air pollution, pesticides. It is the yearning in your friends voices as they gaze at their first child, playing in their too-small apartment, and say, Wed love to have another, but It is the pain that comes from lunging toward transcendence and finding it out of reach.

Seen from this perspective, the conversation around reproduction can and should take on some of the urgency of the climate change debate. We are recognizing natures majesty too late, appreciating its uniqueness and irreplaceability only as we watch it burn.

I see a lot of parallels between this tipping point that people feel in their intimate lives, around the question of reproduction under capitalism, also playing out in broader existential conversations about the fate of the planet under capitalism, said Sara Matthiesen, a historian at George Washington University whose forthcoming book examines family-making post-Roe v. Wade. It seems like more and more people are being pressed to this place of, O.K., this system of value is literally going to kill us.

Conversations about reproduction and environmental sustainability have long overlapped. Thomas Malthus worried that population growth would outstrip the food supply. The 1970s saw the emergence of ecofeminism. Since the 1990s, reproductive justice groups have sought a better planet for all children. Todays BirthStrikers disavow procreation due to the severity of the ecological crisis.

While climate catastrophe has revived elements of the insidious discourse of population control, it has also prompted a new wave of activism, born of an understanding of just how deeply these foundational components of life reproduction and the health of the planet are linked, and the collective action that is required to sustain them.

The first step is renouncing the individualism celebrated by capitalism and recognizing the interdependence that is essential for long-term survival. We depend on our water supply to be clean, and our rivers depend on us not to poison them. We ask our neighbors to watch our dogs or water our plants while were away, and offer our help in kind. We hire strangers to look after our children or aging parents, and trust in their compassion. We pay taxes and hope those we elect spend that money to keep roads safe, schools open, and national parks protected.

These relationships, between us and the natural world, and us and one another, testify to the interdependence that capitalist logic would have us disavow.

Reproduction is the ultimate nod to interdependence. We depend on at least two people to make us possible. We gestate inside another human, and emerge with the help of doctors or doulas or kin. We grow up in environments and communities that shape our health, safety and values. We must find concrete ways to recognize this interdependence and resolve to strengthen it.

One of the people upon whom my existence depends, my father, died of a heart attack when I was 7. At some point, I started wearing his watch, a beautiful gold thing that would slide up and down my wrist, heavy with sentiment. This year, on a work trip, I sat down in a hotel lobby to get some writing done. I took the watch off to type, only to realize on a bus going home that Id left it at the hotel. Hours of searching the lobby and sobbing to the staff failed to bring it back.

Later that evening, writing in a journal, I consoled myself by listing some of the things he had left me that I couldnt lose if I tried: the large-ish nose, the sense of humor, the shrimpy stature that curtailed both his basketball career and mine.

In that moment, I understood why I had frozen my eggs. Intellectually, I am skeptical, even critical, of the inherent narcissism of preserving ones own genetic material when there are already so many children without parents. Even as I was going through with it, injecting drugs into my abdomen each night until it came to resemble a dart board, I struggled to articulate why, at least in a way that made sense to me.

But as I reflected on the immaterial gifts I like to think I inherited from him, it became clear I craved genetic continuity, however fictitious and tenuous it might be. I recognized then something precious and inexplicable in this yearning, and glimpsed how devastating it might be to be unable to realize it. For the first time, I felt justified in my impulse to preserve some little piece of me that, in some way, contained a little piece of him, which one day might live again.

Anna Louie Sussman is a writer on gender, reproduction and economics. This article was produced in partnership with the Pulitzer Center on Crisis Reporting.

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Anna Louie Sussman: Is this the end of babies? - Salt Lake Tribune

Endometriosis Suppressed in Patient Cells Treated with Active Component of Ginseng, Study Says – Endometriosis News Today

An active ingredient of the ginseng medicinal plant may suppressendometriosis by regulating cell death and blood vessel formation processes in the endometriumor lining of the uterus, a study in cells from patients suggests.

The study, Ginsenoside Rg3 attenuates endometriosis by inhibiting the viability of human ectopic endometrial stromal cells through the nuclear factor-kappaB signaling pathway was published in the Journal of Gynecology Obstetrics and Human Reproduction.

Although endometriosis has long been considered a disease of uncontrolled and aberrant growth of endometrium tissue outside of the uterus, the exact molecular mechanisms disrupted in this disorder remain unknown.

Research indicates that there is not just one single molecular culprit, but several signaling pathways that contribute to the disease mechanism of endometriosis, including ones involved in cell proliferation, cell adhesion and programmed death (apoptosis), blood vessel formation (angiogenesis), and immune function.

The protein complex NF-kappaB (NF-kB) is involved in such processes, and has been shown to favor the development and maintenance of endometriosis by preventing cell death and stimulating proliferation of various cell types, like endometrial and endometriosis-related cells, as well as inflammation.

Ginsenoside Rg3 is a main effective component extracted from ginseng, which is a Chinese medical herb, the scientists wrote.

In rats, the compound was seen to inhibit the development of new endometriosis lesions, reduce the volume of existing lesions, and halt the formation of new blood vessels. Nonetheless, the effects of Rg3 on endometriosis-related cells from people is still poorly understood.

Investigators at the Women Health Center of Shanxi and Childrens Hospital of Shanxi, in China, evaluated this compound on human endometrial cells in a lab dish.

Endometrial tissue samples were obtained from six women (ages 2840 years) with ovarian endometriosis and regular menstrual cycles. Using tissue from their endometrial lesions, scientists grew endometrial stromal cells, or connective tissue cells found in the endometrium, in the lab.

Cells were then treated with five distinct doses of Rg3 (0, 25, 50, 100, and 150 mg/mL) and the compounds effects were evaluated at 24, 48 and 72 hours post-treatment.

Ginsenoside Rg3 was found to stop the cells from spreading in a time- and dose-dependent manner, with higher doses being associated with lesser cell proliferation.

Scientists reported that after 48, 72h, 100 mg/mL and 150 mg/mL of concentration of Rg3 inhibited the viability of human ectopic endometrial cells, which was found to be statistically significant in comparison to untreated cells.

Rg3 also significantly lowered levels of the NF-B p65 subunit and the protein TNF- in diseased cells, suggesting the NF-B pathway plays a role in the mechanism of endometriosis. Of note, women with endometriosis are known to have very active NF-B and high serum levels TNF-, a potent NF-B inducer.

A significant decrease in the concentration of vascular endothelial growth factor (VEGF), which stimulates new blood vessel formation, and a significant increase in the levels of caspase 3, a protein that regulates the apoptosis process, were also seen after Rg3 was used.

When TNF- was administered together with Rg3, the latter was able to neutralize TNF--induced changes, including cell death and blood vessel formation.

Our results indicate that Ginsenoside Rg3 suppresses endometriosis by reducing the viability of human ectopic [outside of the normal location] endometrial stromal cells involving the nuclear factor-kappaB signaling pathway, the researchers concluded.

NF-B signaling pathway may be a potential target in the process of the Rg3 treatment for endometriosis, they added.

With over three years of experience in the medical communications business, Catarina holds a BSc. in Biomedical Sciences and a MSc. in Neurosciences. Apart from writing, she has been involved in patient-oriented translational and clinical research.

Total Posts: 146

Margarida graduated with a BS in Health Sciences from the University of Lisbon and a MSc in Biotechnology from Instituto Superior Tcnico (IST-UL). She worked as a molecular biologist research associate at a Cambridge UK-based biotech company that discovers and develops therapeutic, fully human monoclonal antibodies.

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Endometriosis Suppressed in Patient Cells Treated with Active Component of Ginseng, Study Says - Endometriosis News Today

Educational video: Human reproduction for kids | Happy …

Today we are going to learn about our origin, lets learn about the human reproduction.

Reproduction develops in three stages: conception, pregnancy and childbirth and for it to take place both female and males need to intervene. We already know that the male reproduction system produces sperm and the female reproduction system egg cells

Well, fertilization is when a mans sperm cell and a womans egg cell released from the ovaries, unite and this happens inside the womans body, normally in the fallopian tube. In order for that to occur, semen, which carries hundreds of thousands of sperm cells, must first pass through the vagina into the uterus to finally reach the fallopian tubes. Of all the millions of sperm cells, only one will be able to penetrate and fertilize the ovum creating a zygote. Now gestation of the fetus can occur within the female uterus

Pregnancy is the stage were a new human being is formed and begins to grow inside its mothers womb. It lasts around nine months, and during this period the zygote begins to divide into many cells growing into a fetus. Bit by bit the new little being, housed in the uterus and connected by an umbilical cord to its mother, continues to grow as well as developing all its organs. In only two months of gestation the embryo already looks like a baby.

By the way, the baby receives its nutrition and oxygen through the umbilical cord.The mothers body also goes through big changes, her tummy, for example grows much bigger.

Childbirth occurs around the ninth month of gestation and is when the baby exits into the world through the vagina Normally a baby is born head first, followed by the rest of its body. After a baby is born the umbilical cord is cut and do you know what happens? well the scar that is left is our belly button. Interesting, isnt it?

Now we have learnt about the human reproduction and its three phases: conception, pregnancy and childbirth. I hope you found it interesting

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Stress and Infertility – WebMD

Doctors offer insights on how daily stress can disrupt fertility -- and how relaxation can help.

"You're just trying too hard."

"You're too stressed. Just relax and it will happen."

"You've got to calm down and let nature take its course."

If you've been trying six months or more to get pregnant, you've probably lost count of the number of times well-meaning friends and family offered this or similar advice.

Though the idea that "trying too hard" was once a popular notion, dramatic advances in infertility treatments -- particularly in the past decade -- all but did away with that idea.

Now, however, the wheel has turned yet again, and doctors are once more looking to the idea that stress -- and sometimes "trying too hard" -- may actually play a role in up to 30% of all infertility problems.

"It's becoming more and more important, in terms of what studies we do, to focus our efforts on the physiological effects of stress and how they may play a role in conception," says Margareta D. Pisarska, MD, co-director of Center for Reproductive Medicine at Cedars Sinai Medical Center in Los Angeles and editor-in-chief of the American Society for Reproductive Medicine News.

While doctors say that right now there aren't enough data to draw a clear and obvious link, many believe it's only a matter of time before we connect all the dots and see the bigger picture.

"What we do know now is that when stress-reduction techniques are employed, something happens in some women that allows them to get pregnant when they couldn't get pregnant before," says Allen Morgan, MD, director of Shore Institute for Reproductive Medicine in Lakewood, N.J.

While the exact pathways between fertility and stress remain a mystery, Morgan believes hormones like cortisol or epinephrine -- which rise and often remain high during times of chronic stress -- play a key role.

Morgan says that it's also possible that reducing stress may help enhance proteins within the uterine lining that are involved in implantation. She says that stress reduction may increase blood flow to the uterus, which also affects conception.

Pisarska tells WebMD that the effects of stress may be different for each woman.

"Stress may cause one set of reactions in one woman, and something else in another, so ultimately the reasons behind how or why stress impacts fertility may also be very individual," says Pisarska.

While doctors may not know the exact links between stress and fertility, a series of studies shows the impact is hard to ignore.

In research published in the journal Human Reproduction, doctors compared pregnancy rates in couples that reported being stressed and those who were not.

What they found: Pregnancy was much more likely to occur during months when couples reported feeling "good" -- happy and relaxed. It was less likely to occur during the months they reported feeling tense or anxious.

But it's not just natural (unassisted) pregnancies that are affected. In research published in Fertility and Sterility in 2005, experts at the University of California at San Diego reported that stress may play a role in the success of infertility treatments, including in vitro fertilization (IVF).

After administering a series of questionnaires designed to measure patients' stress levels, the researchers found that women who scored highest -- indicating the highest levels of stress -- had ovulated 20% fewer eggs compared with women who were less stressed.

Moreover, of those who were able to produce eggs, those who were most stressed were 20% less likely to achieve fertilization success.

Advances in infertility treatments are such that for nearly every block causing infertility, there is a 60% to 70% chance that a medical fix can turn those baby-making odds around, says Jamie A. Grifo, MD, PhD, director of the division of reproductive endocrinology at the NYU Medical Center in New York City. He says "even if stress is causing a problem -- such as poor-quality eggs -- there are medications and procedures that can help."

However, for up to 40% of couples, no discernable reason for infertility can be found. And it is in this group that Morgan believes the effects of stress are most profound.

"Twenty years ago the rate of unexplained infertility was between 10% and 20%. Today I see up to 40%. Women's bodies aren't different, but their stress levels are, and combined with the ticking of the biological clock, I believe it sets the stage for infertility," says Morgan.

Moreover, doctors say often the stress of actually undergoing infertility treatments can be so great it can stop even the most successful procedures from working.

"The whole process of undergoing fertility treatment is pretty nerve racking, partly because it's a series of hurdles that must be jumped at each step of the way. It's a period of time that in and of itself is very stressful," says Dorothy Greenfeld, MSW, director of behavioral services at the Yale Fertility Center of Yale University.

If you already have problems with stress, she says, the treatments themselves can definitely turn your tension up a notch or two.

While it may be a while before the pathway between stress and infertility is clear, what is known right now is that reducing stress levels seems to help.

Some research in this area shows that, for many women, acupuncture could hold the key.

In studies conducted in Germany and published in the journal Fertility and Sterility, women enrolled in an infertility program underwent acupuncture treatments just prior to and just after an embryo transfer into the uterus -- the final step in an in vitro fertilization procedure.

The result: Compared to women who did not have the acupuncture treatment, those who did had a significantly higher rate of pregnancy -- 42.5% compared with 26.3% in the group not having acupuncture.

"I don't think we know if acupuncture actually reduces stress but it may help counterbalance some of the effects of stress on the reproductive system," says Grifo, who indicates that at least three studies thus far have proven its benefits on fertility.

Other studies have found that for some women, massage may hold another key to reducing infertility stress. In research published in the International Journal of Neuroscience in 2004, doctors found that massage therapy worked to decrease the body's physical signals of stress, including heart rate and brain waves.

And while it wasn't tested on infertility patients, Morgan feels so strongly that it will make a difference, he recently launched his own study to test the impact of lower body massage therapy on women undergoing infertility treatments,

"The first group is receiving a gentle form of massage therapy on their feet and legs just prior to either an insemination or an embryo transfer; the matched group is going straight into treatment without any stress-reducing therapy," says Morgan.

While he says it's still too early to predict results, he suspects the outcome may definitely favor massage therapy.

At Grifo's center at New York University, infertility patients are routinely referred to in-house programs that offer both guided imagery and foot reflexology, all in an effort to reduce stress.

"We're not studying it in a scientific way, but we offer it and we recommend it, and the women who become involved seem to feel better, and that's what matters most to us. If it helps the quality of life for patients seeking fertility treatments, that's a very big thing," says Grifo.

Of course the one thing experts say probably won't help reduce stress in your life is hearing people tell you to relax. In fact, experts say it could even generate more stress.

"I never want to tell patients to just 'relax' because you can't tell a person who's already nervous to stop being nervous. That just isn't helpful," says Greenfeld.

What she does recommend, however, is for each woman to look into her own life and try to find tiny spaces where she can give her body and her mind a respite from the stresses of every day living.

Says Greenfeld: "Don't just try to relax because you think that it's going to help you get pregnant. But do relax just because it feels good, because it's comfortable, and because when you do feel good, you're healthier overall, and that can never be a bad thing for conception."

SOURCES: Margareta Pisarska, MD, co-director, Center for ReproductiveMedicine, Cedars Sinai Medical Center, Los Angeles; editor-in-chief,American Society for Reproductive Medicine News. Allen Morgan, MD,director, Shore Institute for Reproductive Medicine, Lakewood, N.J. Jamie A.Grifo, MD, PhD, director, division of reproductive endocrinology, NYU MedicalCenter, New York. Dorothy Greenfeld, MSW, director of behavioral services, YaleFertility Center of Yale University, New Haven, Conn. Sanders, K.A. HumanReproduction, Oct 1997; vol 12: pp 2324-2329. Klonoff-Cohen, H.Fertility and Sterility, April 2004; vol 8. Paulus, W. Fertilityand Sterility, April 2002; vol 77. Diego, M, Journal ofNeuroscience, 2004; vol 114: pp. 31-45.

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Stress and Infertility - WebMD

How We Do It: The Evolution and Future of Human …

I have lectured for years on the topic of this book, and done research on primate reproduction. But even so, I kept coming across information and ideas new to me. The author's knowledge is encyclopedic. From mating, through pregnancy and birth, to baby care, to contraception and its opposite, we get an absorbing account of the evolutionary and functional biology of reproduction. Buy the book! It's a fascinating read, a real romp.Alexander Harcourt, author of Human Biogeography and coauthor of Gorilla Society

Here at last is a thought-provoking, accurate, and entertaining account of the origins and present status of human reproduction. Robert Martin, a world authority on evolutionary biology, explores how evolution has shaped the patterns of reproductive physiology and the sexual and maternal behavior that characterize modern humans. He accomplishes this task with great clarity and wit.Alan Dixson, Professor of Biological Sciences, Victoria University of Wellington, New Zealand, and author of Sexual Selection and the Origins of Human Mating Systems

[An] amiable information tour through the evolutionary history of mating, pregnancy, birth, and babies.... An intelligent, open-minded guide to the animal processes that somehow seem to make us most fully human.Boston Globe

Mr. Martin's humble but crucial acknowledgment that biology is unavoidably complicatedthat we can't capture millennia of evolution or decades of research in glib sayings about the sexes' planetary origins or in single surveys of psychology undergraduatesis what makes How We Do It so compelling.... No Mars and Venus, no extrapolations about why we evolved to loveor hatestrip clubs or whether bottle-feeding dooms a child to a life of puerile amusements and a career at the Kwik-E-Mart. Here instead are the facts of life as you may have never thought about them.Wall Street Journal

"An accessible and affordable, yet rigorously reviewed, scholarly trade book that comes across as a career achievement. Buy it, read it, carefully consider it, and you will be on your way to becoming a cognoscenti in a diversity of fields related to humans and their evolution and reproductive biology.Evolutionary Psychology

This fascinating, comprehensive look at human evolution raises important questions about what everything from bottle-fed babies to assisted reproduction means for the future of the species.... A must-read for anyone interested in human evolution.Booklist

A fascinating treatment of a complex subject.Kirkus Reviews

Martin, an anthropologist and curator at Chicago's Field Museum, covers every aspect of human reproductionfrom fertilization to infant carein this thoughtful, well-written book.... His comparative analysis and expertise permits him to draw compelling conclusions.... He also raises thought-provoking questions, such as why so many spermon the order of 250 billionare released when only one can inseminate the egg.Publishers Weekly

Robert Martin is one of our leading researchers on human biology and evolution, having made a career of generating novel and game-changing conclusions about why our bodies and organs look the way they do. In How We Do It, he brings his authoritative voice to a compelling, readable, and enlightening account about human reproduction. Read Robert Martin and you will not look at human bodies the same way again.Neil Shubin, paleontologist, The University of Chicago, and author of Your Inner Fish

How We Do It is a fascinating account of the natural history of human reproduction. As modern medicine and technology increasingly encroach on conception, childbirth, and infant care, it is eye-opening to learn about how these processes actually evolved in our species. Robert Martin has written the perfect birds-and-bees guide for curious grown-ups.Lise Eliot, Associate Professor of Neuroscience, Chicago Medical School, Rosalind Franklin University, and author of What's Going On In There?: How the Brain and Mind Develop in the First Five Years of Life

Intriguing .... [filled with] interesting factoids.Washington Post

Misconceptions, cultural taboos, misguided assumptions about gender, and general prudishness have held back research on sex and its influence on the evolution of our species. Robert Martin's How We Do It provides a refreshing account of what we do know about the subject, how we got to this stage of awareness, and where we go next. Starting with an overview of sperm and eggs and ending with birth control and in vitro fertilization, Martin, who has been researching these subjects for decades as curator of biological anthropology at the Field Museum in Chicago, takes off the blinders. He puts human sex into the broad context of the genetic, morphological, and behavioral variation that exists in the animal kingdom.American Scientist

Biological anthropologist Robert Martin wields decades of research to get at the evolutionary facts and inform people's reproductive decisions.... Fascinating detours aboundsuch as the successful, and sensitive, toilet training of six-month-old babies by Kenya's Digo people.Nature

A gold mine of cocktail party trivia.... People who are fascinated by humans' past should read this book.Science News

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How We Do It: The Evolution and Future of Human ...

24.4. Hormonal Control of Human Reproduction Concepts of …

Learning Objectives

By the end of this chapter, you will be able to:

The human male and female reproductive cycles are controlled by the interaction of hormones from the hypothalamus and anterior pituitary with hormones from reproductive tissues and organs. In both sexes, the hypothalamus monitors and causes the release of hormones from the pituitary gland. When the reproductive hormone is required, the hypothalamus sends a gonadotropin-releasing hormone (GnRH) to the anterior pituitary. This causes the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary into the blood. Note that the body must reach puberty in order for the adrenals to release the hormones that must be present for GnRH to be produced. Although FSH and LH are named after their functions in female reproduction, they are produced in both sexes and play important roles in controlling reproduction. Other hormones have specific functions in the male and female reproductive systems.

At the onset of puberty, the hypothalamus causes the release of FSH and LH into the male system for the first time. FSH enters the testes and stimulates the Sertoli cells to begin facilitating spermatogenesis using negative feedback, as illustrated in

Figure 24.14. LH also enters the testes and stimulates the interstitial cells of Leydig to make and release testosterone into the testes and the blood.

Testosterone, the hormone responsible for the secondary sexual characteristics that develop in the male during adolescence, stimulates spermatogenesis. These secondary sex characteristics include a deepening of the voice, the growth of facial, axillary, and pubic hair, and the beginnings of the sex drive.

Figure 24.14. Hormones control sperm production in a negative feedback system.

A negative feedback system occurs in the male with rising levels of testosterone acting on the hypothalamus and anterior pituitary to inhibit the release of GnRH, FSH, and LH. The Sertoli cells produce the hormone inhibin, which is released into the blood when the sperm count is too high. This inhibits the release of GnRH and FSH, which will cause spermatogenesis to slow down. If the sperm count reaches 20 million/ml, the Sertoli cells cease the release of inhibin, and the sperm count increases.

The control of reproduction in females is more complex. As with the male, the anterior pituitary hormones cause the release of the hormones FSH and LH. In addition, estrogens and progesterone are released from the developing follicles. Estrogen is the reproductive hormone in females that assists in endometrial regrowth, ovulation, and calcium absorption; it is also responsible for the secondary sexual characteristics of females. These include breast development, flaring of the hips, and a shorter period necessary for bone maturation. Progesterone assists in endometrial re-growth and inhibition of FSH and LH release.

In females, FSH stimulates development of egg cells, called ova, which develop in structures called follicles. Follicle cells produce the hormone inhibin, which inhibits FSH production. LH also plays a role in the development of ova, induction of ovulation, and stimulation of estradiol and progesterone production by the ovaries. Estradiol and progesterone are steroid hormones that prepare the body for pregnancy. Estradiol produces secondary sex characteristics in females, while both estradiol and progesterone regulate the menstrual cycle.

The Ovarian Cycle and the Menstrual Cycle

The ovarian cycle governs the preparation of endocrine tissues and release of eggs, while the menstrual cycle governs the preparation and maintenance of the uterine lining. These cycles occur concurrently and are coordinated over a 2232 day cycle, with an average length of 28 days.

The first half of the ovarian cycle is the follicular phase shown in Figure 24.15. Slowly rising levels of FSH and LH cause the growth of follicles on the surface of the ovary. This process prepares the egg for ovulation. As the follicles grow, they begin releasing estrogens and a low level of progesterone. Progesterone maintains the endometrium to help ensure pregnancy. The trip through the fallopian tube takes about seven days. At this stage of development, called the morula, there are 30-60 cells. If pregnancy implantation does not occur, the lining is sloughed off. After about five days, estrogen levels rise and the menstrual cycle enters the proliferative phase. The endometrium begins to regrow, replacing the blood vessels and glands that deteriorated during the end of the last cycle.

Which of the following statements about hormone regulation of the female reproductive cycle is false?

Just prior to the middle of the cycle (approximately day 14), the high level of estrogen causes FSH and especially LH to rise rapidly, then fall. The spike in LH causes ovulation: the most mature follicle, like that shown in Figure 24.16, ruptures and releases its egg. The follicles that did not rupture degenerate and their eggs are lost. The level of estrogen decreases when the extra follicles degenerate.

Figure 24.16. This mature egg follicle may rupture and release an egg. (credit: scale-bar data from Matt Russell)

Following ovulation, the ovarian cycle enters its luteal phase, illustrated in Figure 24.15 and the menstrual cycle enters its secretory phase, both of which run from about day 15 to 28. The luteal and secretory phases refer to changes in the ruptured follicle. The cells in the follicle undergo physical changes and produce a structure called a corpus luteum. The corpus luteum produces estrogen and progesterone. The progesterone facilitates the regrowth of the uterine lining and inhibits the release of further FSH and LH. The uterus is being prepared to accept a fertilized egg, should it occur during this cycle. The inhibition of FSH and LH prevents any further eggs and follicles from developing, while the progesterone is elevated. The level of estrogen produced by the corpus luteum increases to a steady level for the next few days.

If no fertilized egg is implanted into the uterus, the corpus luteum degenerates and the levels of estrogen and progesterone decrease. The endometrium begins to degenerate as the progesterone levels drop, initiating the next menstrual cycle. The decrease in progesterone also allows the hypothalamus to send GnRH to the anterior pituitary, releasing FSH and LH and starting the cycles again. Figure 24.17 visually compares the ovarian and uterine cycles as well as the commensurate hormone levels.

Which of the following statements about the menstrual cycle is false?

As women approach their mid-40s to mid-50s, their ovaries begin to lose their sensitivity to FSH and LH. Menstrual periods become less frequent and finally cease; this is menopause. There are still eggs and potential follicles on the ovaries, but without the stimulation of FSH and LH, they will not produce a viable egg to be released. The outcome of this is the inability to have children.

The side effects of menopause include hot flashes, heavy sweating (especially at night), headaches, some hair loss, muscle pain, vaginal dryness, insomnia, depression, weight gain, and mood swings. Estrogen is involved in calcium metabolism and, without it, blood levels of calcium decrease. To replenish the blood, calcium is lost from bone which may decrease the bone density and lead to osteoporosis. Supplementation of estrogen in the form of hormone replacement therapy (HRT) can prevent bone loss, but the therapy can have negative side effects. While HRT is thought to give some protection from colon cancer, osteoporosis, heart disease, macular degeneration, and possibly depression, its negative side effects include increased risk of: stroke or heart attack, blood clots, breast cancer, ovarian cancer, endometrial cancer, gall bladder disease, and possibly dementia.

A reproductive endocrinologist is a physician who treats a variety of hormonal disorders related to reproduction and infertility in both men and women. The disorders include menstrual problems, infertility, pregnancy loss, sexual dysfunction, and menopause. Doctors may use fertility drugs, surgery, or assisted reproductive techniques (ART) in their therapy. ART involves the use of procedures to manipulate the egg or sperm to facilitate reproduction, such as in vitro fertilization.

Reproductive endocrinologists undergo extensive medical training, first in a four-year residency in obstetrics and gynecology, then in a three-year fellowship in reproductive endocrinology. To be board certified in this area, the physician must pass written and oral exams in both areas.

The male and female reproductive cycles are controlled by hormones released from the hypothalamus and anterior pituitary as well as hormones from reproductive tissues and organs. The hypothalamus monitors the need for the FSH and LH hormones made and released from the anterior pituitary. FSH and LH affect reproductive structures to cause the formation of sperm and the preparation of eggs for release and possible fertilization. In the male, FSH and LH stimulate Sertoli cells and interstitial cells of Leydig in the testes to facilitate sperm production. The Leydig cells produce testosterone, which also is responsible for the secondary sexual characteristics of males. In females, FSH and LH cause estrogen and progesterone to be produced. They regulate the female reproductive system which is divided into the ovarian cycle and the menstrual cycle. Menopause occurs when the ovaries lose their sensitivity to FSH and LH and the female reproductive cycles slow to a stop.

Answers

estrogenreproductive hormone in females that assists in endometrial regrowth, ovulation, and calcium absorption

follicle stimulating hormone (FSH)reproductive hormone that causes sperm production in men and follicle development in women

gonadotropin-releasing hormone (GnRH)hormone from the hypothalamus that causes the release of FSH and LH from the anterior pituitary

inhibinhormone made by Sertoli cells; provides negative feedback to hypothalamus in control of FSH and GnRH release

interstitialcell of Leydigcell in seminiferous tubules that makes testosterone

luteinizing hormone (LH)reproductive hormone in both men and women, causes testosterone production in men and ovulation and lactation in women

menopauseloss of reproductive capacity in women due to decreased sensitivity of the ovaries to FSH and LH

menstrual cyclecycle of the degradation and re-growth of the endometrium

ovarian cyclecycle of preparation of egg for ovulation and the conversion of the follicle to the corpus luteum

ovulationrelease of the egg by the most mature follicle

progesteronereproductive hormone in women; assists in endometrial re-growth and inhibition of FSH and LH release

Sertoli cellcell in seminiferous tubules that assists developing sperm and makes inhibin

testosteronereproductive hormone in men that assists in sperm production and promoting secondary sexual characteristics

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24.4. Hormonal Control of Human Reproduction Concepts of ...

20 bad habits that are lowering your sperm count – The San Diego Union-Tribune

Sperm count is kind of a big deal right now in the United States. According to a recent and terrifying study published in the journalHuman Reproduction Update, sperm counts in the United States, Europe, Australia, and New Zealand are all plummeting.

And by plummeting, we mean plummeting. Sperm counts have decreased on average by over 50 percent.

For 20 Bad Habits That Are Lowering Your Sperm Count, click here.

The average cost of in vitro fertilization in the U.S. is currently about $11,000 to $12,000, and the prevalence of these procedures is equally concerning. More women are using in vitro methods of fertilization to get pregnant than ever before; this could in part be due to the high mortality rate of sperm making fertilization less likely through more natural methods.

There are many hypotheses out there about what men could do better to preserve their sperm. They range from reasonable to ridiculous - drinking Mountain Dew, for example, has no proven effect on your sperm at all. However, some sperm-massacring habits that at first sound ridiculous are not to be messed with.

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20 bad habits that are lowering your sperm count - The San Diego Union-Tribune

THE 24 HOUR SHIFT: It’s OK to be different – Spotlight News

Mar 27, 2020 Spotlight News Parent Pages, Parenting Columns

By THERESA DAVIS

Why am I the only one who looks different?

Oh, boy. That is a question that covers biology, genetics and emotional support. If you really want to get your hands dirty, throw in sociology. Maybe even some socioeconomics, too!

If you think your adopted or foster child is too young to know about human reproduction, dont tell them how babies are made but why. Babies grow from love. Which is sometimes true. From there, one day, youre going to have to go into what is either going on with your childs birth parents or what happened between them that made them separate from each other or separate from your child. Oh, the joys of adoptive parenthood!

Your child is going to feel different in your family, especially if their race or ethnicity is different from your familys. You can explain briefly about genetics to your young child or go more in depth for an older one. It makes for a good homeschooled biology lesson.

Physical differences aside, your adoptive child may enjoy things that the adoptive family doesnt or may be the quiet one in a rowdy family crowd. Or your child may be more sensitive or react to stress differently than their adoptive family. Yes, your child will be different in some way to your family. Whats important is that those differences are celebrated.

Your child is unique. Encourage ownership of her differences while pointing out what you have in common. Your child will find her place in the family, because she is your family. Being a little different wont change that. Biology and genetics do make people who look and think and talk alike, but only love can make a family.

Theresa Davis is a former early childhood educator and has worked in childcare centers for more than 15 years. She is also an adoptive mother, living and taking care of her family in the Capital District.

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THE 24 HOUR SHIFT: It's OK to be different - Spotlight News

Women told NOT to have IVF amid the coronavirus outbreak by fertility watchdog – Infosurhoy

Women are being urged not to have IVF amid the coronavirus outbreak over fears the virus negatively affects pregnancy.

A statement issued by the European Society of Human Reproduction and Embryology says all couples considering fertility treatment should avoid becoming pregnant at this time.

It advised those who are already having IVF to consider freezing their eggs or the embryos they have created for a pregnancy until the pandemic is halted.

Meanwhile a mother-to-be is concerned hospitals will be overwhelmed when she is due to give birth next month.

Natalie Lyons, from Derby, is due to give birth to her second child in a month. She says she is doing her best not to panic, but is concerned about hospitals becoming overwhelmed and has struggled to get hold of supplies such as nappies.

The 33-year-old mother-of-one has followed the Governments advice and yesterday stopped her job as a hairdresser to start maternity leave three weeks early.

Im trying not to panic but when you have a baby you need all these supplies, and how are we meant to get them if were advised to stay inside?

ESHRE says all those considering or planning treatment to have a baby should put it on hold as a precautionary measure.

But many of the 68,000 women who choose to have IVF every year in the UK are in their late thirties and have little time to delay.

It comes following reports of women infected with coronavirus giving birth to premature babies in China.

However ESHRE which provides guidance for fertility clinics across Europe and in the UK notes the reports are based on limited data with no strong evidence.

In its statement, ESHRE said: As a precautionary measure and in line with the position of other scientific societies in reproductive medicine we advise that all fertility patients considering or planning treatment, even if they do not meet the diagnostic criteria for Covid-19 infection, should avoid becoming pregnant at this time.

The NHS today revealed it would send pregnant staff to lower risk hospitals in areas with few cases of the virus as the crisis escalates over fears for their safety.

And mothers-to-be are strongly advised to follow social distancing measures such as avoiding public transport, socialising in groups or going to the cinema or reataruants.

Despite this, the Royal College of Midwives yesterday urged them to attend antenatal appointments.

The UKs chief medical adviser, Professor Chris Whitty, said there is currently no evidence to suggest any coronavirus-related complications in pregnancy.

But he added the UK was still very early in what we know about this, stating: Infections and pregnancy are not a good combination in general and that is why we have taken the very precautionary measure while we try and find out more.

Yesterday the Prime Minister said millions of the elderly and most vulnerable will need to shield themselves from social contact and stay at home for three months.

But theadvice stopped short of defining explicitly who needs to stay at home.

Pregnant women in the UK are expected to be among those told in the coming days to self-isolate for 12 weeks and avoid non-essential contact with others.

Boris Johnson acknowledged that drastic action was required to quell the spread of the deadly coronavirus which has killed 55 and infected more than 1,500 throughout the country.

By the weekend, those with the most serious conditions will be advised to take steps to ensure they are largely shielded from social contact for around 12 weeks.

It comes afterNHS hospitals were told tocancel operations for three months in a bid to free up 30,000 beds in preparation for a surge in coronavirus patients.

In a call to arms letter sent to hospital bosses today, NHS Englandsaid trusts should cancel all non-urgent surgeries starting from April 15 for at least 12 weeks.

It is hoped the measure could free up a third of the 100,000 hospital beds in England so the health service is not overwhelmed by the pandemic.

Staff who have family members self-isolating at home will also be offered to stay in a hotel for free so they can continue working and not have to join them in quarantine.

The letter, which laid out the health services coronavirus battle plan, also called for all inpatients who are medically fit to be discharged immediately.

It stated that staff must take part in special training for dealing with a high number of patients on ventilators andbegin work setting up makeshift intensive care wards.

The call to arms comes after the UK suffered 407 more coronavirus infections and two more deaths.It means there are now officially 1,950 people with the disease and 71 have succumbed to it.

Any cancer operations and patients needing emergency treatment will not be affected by the new measures.

The letter from NHS England chief executive Simon Stevens said: The operational aim is to expand critical care capacity to the maximum; free up 30,000 (or more) of the English NHSs 100,000 general and acute beds.

Assume that you will need to postpone all non-urgent elective operations from 15 April at the latest, for a period of at least three months.

However you also have full local discretion to wind down elective activity over the next 30 days as you see best, so as to free up staff for refresher training, beds for Covid-19 patients, and theatres/recovery facilities for adaptation work.

In the meantime hospitals were told to do as much elective surgery, such as hip operations and knee replacements, as possible so that by mid-April there are thousands more free beds.

Sir Simon warned frontline staff that dealing with the outbreak was going to be a very difficult time.

He said those required to self-isolate because a family member has symptoms or has tested positive will be offered to stay in a hotel.

The letter adds: For those staff affected by PHEs 14 day household isolation policy, staff should on an entirely voluntary basis be offered the alternative option of staying in NHS-reimbursed hotel accommodation while they continue to work.

Pregnant, elderly and staff with underlying conditions will either be moved to lower risk hospitals in areas with few cases, according to the document.

Clinicians who fall under this category will be able to do online or video consultations from home.

As well as keeping staff healthy, Sir Simon said it was vital NHS staff were trained about how to care for ventilated patients.

He gave trusts two weeks to put all clinical and patient facing staff through refresher training.

Sir Simon added that patients who did not need to be in hospital should be discharged as quickly as possible adding: Community health providers must take immediate full responsibility for urgent discharge of all eligible patients identified by acute providers on a discharge list.

For those needing social care, emergency legislation before Parliament this week will ensure that eligibility assessments do not delay discharge.

This could potentially free up to 15,000 acute beds currently occupied by patients awaiting discharge or with lengths of stay over 21 days.

The letter confirmed that recently retired staff would be asked to return to the health service during the crisis and that medical students would be fast tracked into the NHS.

As the NHS ramped up its coronavirus efforts, the governments chief scientific adviser today revealed there are likely to be as many as 55,000 cases of coronavirusin the UK.

Sir Patrick Vallance said modelling of the spread of the disease in Britain showed that for every death there was likely to be 1,000 positive cases.

Latest official statistics put the death toll at 55 which means it is a reasonable sort of ballpark to think there are now more than 50,000 cases nationwide, he said.

Last week the government estimated the number of cases was likely to be between 5-10,000.

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Women told NOT to have IVF amid the coronavirus outbreak by fertility watchdog - Infosurhoy

Coronavirus pandemic spurs halt to fertility treatments – The Globe and Mail

Ash Mogg, 36, who has had IVF cancelled due to COVID-19, outside her home in Toronto on March 20, 2020.

Tijana Martin/The Globe and Mail

Ash Mogg and her partner waited nearly a year on a list for provincially funded IVF in Ontario. Ms. Mogg, who is 36 and has a low egg reserve, was finally about to start the process in two weeks, but on Wednesday a nurse phoned with heartbreaking news. With all the uncertainty around COVID-19, the Toronto hospital was cancelling infertility treatments indefinitely.

I cried for five hours," Ms. Mogg said. "This whole situation, with COVID, in some ways it has the same feeling as infertility. Everything is so uncertain theres nothing to hold onto.

In the past few days, fertility clinics across Canada have been informing patients that new treatment cycles are being put on hold. They made the move after the Canadian Fertility and Andrology Society, which is not a regulatory body but provides guidance to the industry, issued a recommendation on Wednesday to postpone new insemination, in vitro fertilization and frozen embryo transfers until further notice, citing concerns about health-care resources. (The only exception would be for urgent cases involving cancer patients.)

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Read also: IVF was my last hope to have a baby. All Canadians deserve that hope, too

The American Society for Reproductive Medicine released a similar advisory. And in Europe, the European Society of Human Reproduction and Embryology has cautioned that all fertility patients considering or planning treatment should avoid becoming pregnant at this time, citing the lack of information around how the novel coronavirus that causes COVID-19 affects early pregnancy.

For all the jokes about a forthcoming COVID-19 baby boom as couples around the world isolate in their homes some health professionals are raising red flags about whether its wise to get pregnant amid the outbreak. This alarming warning is driven by concerns about the strain on an already stretched health-care system, a lack of data around how the virus affects the first and second trimesters, and unease about whether hospitals will have the capacity to provide proper care for pregnant women and newborns.

For people like Ms. Mogg, the idea of having to press pause on starting a family is yet another devastating layer to this crisis.

When everything started shutting down, I kind of suspected something like this was going to happen, but it was still a blow, she said. Timing is obviously critical for me.

Fiona Mattatall, a Calgary-based obstetrician and gynecologist, said given all of the uncertainty around COVID-19, she would suggest families consider delaying attempts at getting pregnant until more is known.

This is only a virus weve known about for months, not years, Dr. Mattatall said. When it comes to the first-trimester exposure, it is a giant question mark.

One good bit of news is that an analysis of amniotic fluid and cord blood from nine infected woman who delivered at Zhongnan Hospital of Wuhan University in China this year didnt detect the virus.

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This is hopeful, early information that babies may be protected it the womb, Dr. Mattatall said, adding its still too early to say for certain. (Researchers also determined the virus was not present in breast milk.)

As for the risk to mothers, reports from China suggest that the majority of pregnant woman with confirmed cases suffered just mild to moderate symptoms, and babies born to infected mothers have also done well.

Vanessa Poliquin, co-chair of the infectious disease committee of the Society of Obstetricians and Gynaecologists of Canada, said the absence of information isnt necessarily a bad thing. The virus has been spreading around the world for months now. Its conceivable, said Dr. Poliquin, that women are being infected while pregnant in their first trimester.

And we havent heard of a spike in miscarriages and we havent heard of a spike in rates of abnormalities being seen on anatomy scans, she said. This was not the case with the Zika virus, she said, where health providers saw problems and sounded the alarm.

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So far SOGC has not issued any warnings about delaying pregnancy, but the agencys chief executive officer, Jennifer Blake, said it may be worth considering.

The big unknown is how the pandemic will affect our health-care system and the ability to give routine pregnancy care. For example, will you be able to get an ultrasound when and where you might normally expect, she said. If its an option you may want to wait. If thats not an option, we will make sure you get the care you need.

Tom Hannam, founder of Hannam Fertility in Toronto, said part of the problem is no one knows how long the outbreak will last.

Were looking at something that could be three months or seven months or a year and a half. None of us knows, he said. Whats it going to be like going to a hospital nine months from now? Is it going to be a healthy and safe birth experience?

Some clues can be gleaned from other cities.

Edith Cheng, chief of maternal-fetal medicine at University of Washington hospital in Seattle, one of the early North American epicentres for the outbreak, said theyre currently trying to sort through complicated logistics.

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At present, the hospitals policy is that patients who are positive for COVID-19 cannot have guests. So an infected woman in labour would need to be alone.

Just 12 hours ago [our] pediatric leaders said we are now going to have to recommend, for sure, that [positive] moms and babies are separated because of some limited and new data that reports that babies less than a year old are potentially at higher risk, Dr. Cheng said.

Mothers are able to refuse this recommendation, but what happens at that point is still under discussion.

The complications around infected mothers means it takes more staff resources to handle safely. A delivery earlier this week required 13 staffers.

London is another city thats experiencing a crush of new COVID-19 cases. Last week, we had no cases at my hospital, said Rosemary Townsend, who works at a hospital in the citys south end. This week we have over 30 confirmed.

Hours earlier, her unit delivered its first baby to a mother suspected of being COVID-19 positive. (The confirmation test is pending.)

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In that case, the woman knew she was symptomatic and called in advance. An official met her and her partner in the parking lot and put masks on them. Usually women are moved to different parts of the maternity ward before and after delivery, but in this case the patient was in an isolated area.

Asked if she thinks families should postpone plans to try and get pregnant, Dr. Townsend said she just had this conversation with a friend who happens to work in health care.

Shes 38. She decided that she doesnt want to wait. The risk of waiting and delaying pregnancy is greater than the risk of getting pregnant in the middle of whats going on, Dr. Townsend said.

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Coronavirus pandemic spurs halt to fertility treatments - The Globe and Mail

Nature Guide Journal: Non-living viruses have big effects on living things – Coos Bay World

Tiny viruses are having an enormous effect on our lives right now, from the usual colds and flu to the pandemic of the novel coronavirus, COVID-19.

Possibly the supreme marauder in nature, viruses infect all known forms of life, animals, plants, and fungi -- even bacteria.

Are viruses themselves alive? Thats debatable. Viruses could be thought of as life stripped down to its barest, most essential element: reproduction.

Viruses do not take in nutrients or pass waste; their only structures and processes are those directly related to holding their genetic material and injecting it into a suitable host. Each virus particle, called a virion, is composed of only a handful of parts: genetic material (either DNA or RNA), a protein coat around the genetic material, (usually) an attachment location or mechanism, and (sometimes) an encompassing envelope. Thats it.

The virion is totally inert until it encounters an appropriate cell membrane -- theres no metabolism, no growth, no movement, only waiting. Each kind of virus is limited to infecting a small number of hosts, in some cases, infecting only certain strains of a single species.

At that encounter, the virion attaches to the host cell then injects its genetic material inside. Usually, the genetic material hijacks the cell's processes and directs it to make several dozen copies of the viral genetic material and other components that make a virion. The components then assemble into a number of new virions and burst out of the cell to disperse, usually killing the host cell.

The illness we feel with a viral infection, such as influenza, is a combination of the virus killing its host cells and our bodies' immune response revved up to high gear.

Sometimes, particularly with viruses that attack bacteria, the genetic material is incorporated into the host cell. In those cases, the infected host continues to live and reproduce, passing on the virus material to its own offspring. The viral genetic material inside a host may be forever incorporated in the genetic material of the host. Your DNA, for example, is up to 8% viral DNA.

Occasionally the virus' meddling moves material between bacteria. This mixing can serve the same function as sexual reproduction does in more complicated organisms, increasing the genetic diversity of the bacterial population.

Sometimes the viral DNA/RNA affects the way the biochemistry of the host works. For example, apparently the bacteria that cause botulism, diphtheria, and scarlet fever cause those diseases only when they harbor the genetic material of certain viruses. Too, this effect was likely the cause of seastar wasting disease that has decimated our starfish populations.

For most of us, though, having a lot of human-targeting viruses drifting through our bodies means illness.

Viruses' protein coats have varying durability, causing some to become unable to reproduce in fairly short order if exposed to a foreign environment. Other viruses can remain virulent under a wide range of conditions for great lengths of time.

Although a few chemicals can disable viruses, antibiotics have no effect on these ultimate parasites. What can control potentially dangerous viruses in multi-cellular animals like us is alerting the bodys natural antibody system by vaccinating with dead or disabled viruses or virus parts. The smallpox vaccine eliminated that deadly disease about 1980, and the vaccine for measles, developed in 1960s, is estimated by Merck & Co. to save up to a million lives a year worldwide. Such vaccines take some time to develop, however, and according to the US Centers for Disease Control and Prevention (CDC), a vaccine for COVID-19 wont be available for at least a year.

Why are we encouraged to get a flu vaccine every year? Viruses are so marvelously good at mutating that theres an uncountable variety of them and new ones are evolving constantly. (The annual flu shot vaccinates against the ones expected to be most common and most virulent.)

Sometimes a virus in other animals mutates enough to infect humans and cause disease. It is believed that one of the rhinoviruses that causes human colds was originally a virus in camels, and measles may have been a cattle illness that jumped to humans about 1,000 years ago. Although we dont yet know for sure, preliminary analysis of the RNA of the COVID-19 shows that it may have originally been a virus that used bats, but mutated to use pangolins, then mutated again to use humans.

Tiny viruses are better adapted to passing on genetic material than any living thing. Thats not going to change, so were going to have to adapt our behavior if we want to control their effect on us.

Now, go wash your hands.

For information on how you can arrange an exploration of our fascinating natural history, contact Marty at 541/267-4027, mgiles@wavecrestdiscoveries.com, or http://www.facebook.com/wavecrestdiscoveries. Questions and comments about local natural history are welcome.

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Nature Guide Journal: Non-living viruses have big effects on living things - Coos Bay World