Human Genetics 11 - Complex Genetic Disease podcast
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Category Archives: Human Genetics
GrEENZILLA – Soul Travelers – Video
GrEENZILLA - Soul Travelers
Support truth @ http://www.songstall.com Greenzilla featured on http://www.davidicke.com we are soul travelers, electro-magnetic forces from other planets. And the information is suppressed, cuz if it wasnt u know we could connect the dots at BEST. These mothafuckas re-wiring our mind not letting us be spirituality on the right side. It makes me so angry and in-line what can we do but stand as a society and be blind. One sheep at a time. One sheep at a time. We soul travelers, with Human Genetics bending space and time in patterns. This is created by the black hole and thus is new information we have been sold. As a single dimensional entity of slaves, heading the race, slaving away, and with our cognitive abilities a fairy tale, it seems mankind #39;s abilities have now been fully veiled. THESE MOTHAFUCKAS RE-WIRING OUR MIND NOT LETTING US BE OUR SPIRITUALITY ON THE RIGHT SIDE. IT MAKES ME SO ANGRY AND INLINE BUT WHAT CAN WE DO BUT STAND AS A SOCIETY AND BE BLIND. THEY WANT YOU TO BE BLIND. THEY WANT YOU TO BE BLIND. WE #39;RE SOUL TRAVELERS. WE #39;RE SOUL TRAVELERS. THEY WANT YOU TO BE BLIND. THEY WANT YOU TO BE BLIND. WE #39;RE SOUL TRAVELERS. WE #39;RE SOUL TRAVELERS. WE #39;RE SOUL TRAVELERS. WE #39;RE SOUL TRAVELERS. WE #39;RE SOUL TRAVELERS. WE #39;RE SOUL TRAVELERS. WE #39;RE SOUL TRAVELERS. WE #39;RE SOUL TRAVELERS.From:jeremy2k7Views:90 4ratingsTime:02:34More inMusic
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Ancient Alien Agenda
Ancient Alien Agenda The Control of Humanity
Ancient Alien Agenda Control of Humanity Must See, Certainly Makes You Think! Subscribe and Get the Latest Updates here! Alternative historian Michael Tsarion discussed humankind #39;s future and the "ancient alien agenda," as carried out by unseen elite or controllers. Last hour guests, Chris Forsythe and Wayne Miracle of Metro Paranormal Investigations... Aliens or #39;Nephilim #39; were scientists who lost their technology during a great war 13000 years ago, but it is now being restored, he claimed. This new wave of technology, will follow in the footsteps of Silicon Valley and the computer revolution, yet be presented as a spiritual step forward to the masses, he cautioned. Mankind has been traumatized at various stages, and human consciousness was damaged, such as when the Nephilim tinkered with human genetics, Tsarion explained. This damage makes people more susceptible to being controlled, he noted. The elite plan to further "dumb down" humanity to the level of machines, so that their thinking is mechanical-- this creates the perfect slave..... ......................................................................................................... Subscribe and get the Latest Show Here http://www.youtube.comFrom:Angels2TouchYou2Views:162 0ratingsTime:02:26:04More inScience Technology
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OB Ch01 F Intro to Human Genetics – Video
OB Ch01 F Intro to Human Genetics
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Hidden with Dloc and Timtim – 1 – Video
Hidden with Dloc and Timtim - 1
Download - http://www.hidden-source.com Requires HL2 Story: In the early 1950s human genetics experimentation was taking its first, tentative steps. Amongst many other black projects, a team of British scientists working at an Infinitum Research experimental station stumbled across some remarkable phenomena involving DNA manipulation. This led to deeper research with dangerously unpredictable results, often leading to human patients losing their lives in irresponsible and immoral experiments. Time passed on, and by the mid 1990s the failure rate of the experiments had been reduced from 75% to a mere 15%, enough for Infinitum to move onto the next stage: Biological Light Refraction. The British team were hoping to unravel the possibilities of light manipulation to create the perfect covert military agent. Early into the new millennium, due to a gross miscalculation, a series of tests on Subject 617 led to a massive synaptic trauma leaving the patient with multiple genetic anomalies. The subject was left in constant pain and with unstable DNA. The subject escaped captivity, killing anyone that got in its way. The IRIS (Infinitum Research Interception Squad) team have been deployed to return the subject to a maximum security Infinitum Research facility for further study and dissection. The entire project was considered a failure: all funding ceased and development was discontinued while all records and traces of the experiments were destroyed. Infinitum Research denies all ...From:DxLoCViews:11 0ratingsTime:09:25More inGaming
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Hidden with Dloc and Timtim – 2 – Video
Hidden with Dloc and Timtim - 2
Download - http://www.hidden-source.com Requires HL2 Story: In the early 1950s human genetics experimentation was taking its first, tentative steps. Amongst many other black projects, a team of British scientists working at an Infinitum Research experimental station stumbled across some remarkable phenomena involving DNA manipulation. This led to deeper research with dangerously unpredictable results, often leading to human patients losing their lives in irresponsible and immoral experiments. Time passed on, and by the mid 1990s the failure rate of the experiments had been reduced from 75% to a mere 15%, enough for Infinitum to move onto the next stage: Biological Light Refraction. The British team were hoping to unravel the possibilities of light manipulation to create the perfect covert military agent. Early into the new millennium, due to a gross miscalculation, a series of tests on Subject 617 led to a massive synaptic trauma leaving the patient with multiple genetic anomalies. The subject was left in constant pain and with unstable DNA. The subject escaped captivity, killing anyone that got in its way. The IRIS (Infinitum Research Interception Squad) team have been deployed to return the subject to a maximum security Infinitum Research facility for further study and dissection. The entire project was considered a failure: all funding ceased and development was discontinued while all records and traces of the experiments were destroyed. Infinitum Research denies all ...From:DxLoCViews:5 0ratingsTime:07:56More inGaming
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The Best Of: "The Hidden" – Video
The Best Of: "The Hidden"
David and Steven are joined by friends Scott and BD while playing some Hidden, who #39;ll come out best in this battle to the Death? The IRIS or The Hidden? Download Here: http://www.hidden-source.com Gamer Quarantine are Ross: http://www.youtube.com Steven: http://www.youtube.com David: http://www.youtube.com Jason: http://www.youtube.com Twitter: twitter.com Subscribe for daily gaming videos! What is The Hidden? "In the early 1950s human genetics experimentation was taking its first, tentative steps. Amongst many other black projects, a team of British scientists working at an Infinitum Research experimental station stumbled across some remarkable phenomena involving DNA manipulation. This led to deeper research with dangerously unpredictable results, often leading to human patients losing their lives in irresponsible and immoral experiments. Time passed on, and by the mid 1990s the failure rate of the experiments had been reduced from 75% to a mere 15%, enough for Infinitum to move onto the next stage: Biological Light Refraction. The British team were hoping to unravel the possibilities of light manipulation to create the perfect covert military agent. Early into the new millennium, due to a gross miscalculation, a series of tests on Subject 617 led to a massive synaptic trauma leaving the patient with multiple genetic anomalies. The subject was left in constant pain and with unstable DNA. The subject escaped captivity, killing anyone that got in its way. The IRIS (Infinitum Research Interception Squad ...From:GamerQuarantineViews:52 8ratingsTime:04:56More inGaming
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SCARY GAME – "The Hidden" With Mr.Mitch361, Charlie, and ChildDolphin – Video
SCARY GAME - "The Hidden" With Mr.Mitch361, Charlie, and ChildDolphin
SCARY GAME - "The Hidden" With Mr.Mitch361, Charlie, and ChildDolphin #10140; Stay Updated And Join Videos With Me - twitter.com #10140; Our Challenge: 210 Motivations :)! Let Me Know If You Want More! (Motivation = Like and a Comment) "Show More" to open the description and read on..... "The Hidden" Website - http://www.hidden-source.com ------------------------------------------------------------------------------------------------------------ What is The Hidden? "In the early 1950s human genetics experimentation was taking its first, tentative steps. Amongst many other black projects, a team of British scientists working at an Infinitum Research experimental station stumbled across some remarkable phenomena involving DNA manipulation. This led to deeper research with dangerously unpredictable results, often leading to human patients losing their lives in irresponsible and immoral experiments. Time passed on, and by the mid 1990s the failure rate of the experiments had been reduced from 75% to a mere 15%, enough for Infinitum to move onto the next stage: Biological Light Refraction. The British team were hoping to unravel the possibilities of light manipulation to create the perfect covert military agent. Early into the new millennium, due to a gross miscalculation, a series of tests on Subject 617 led to a massive synaptic trauma leaving the patient with multiple genetic anomalies. The subject was left in constant pain and with unstable DNA. The subject escaped captivity, killing ...From:TheCampingRusherViews:1797 122ratingsTime:11:14More inGaming
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SCARY GAME - "The Hidden" With Mr.Mitch361, Charlie, and ChildDolphin - Video
International Academy of Cardiology: Neil Bowles, Ph.D.: GENETIC CAUSES OF CONGENITAL HEART DEFECTS – Video
International Academy of Cardiology: Neil Bowles, Ph.D.: GENETIC CAUSES OF CONGENITAL HEART DEFECTS
NEW APPROACHES TO IDENTIFY THE GENETIC CAUSES OF CONGENITAL HEART DEFECTS Neil E. Bowles, Ph.D., SB Bleyl, MF Leppert, CB Arrington University of Utah School of Medicine, Eccles Institute of Human Genetics, Salt Lake City, UT, USA Presented at the: International Academy of Cardiology 17th World Congress on Heart Disease Annual Scientific Sessions 2012 Toronto, ON, Canada July 27-30, 2012 Congress Chairman: Asher Kimchi, MD http://www.CardiologyOnline.com Cardiology Online To read more about this presentation click here to download the Word file http://www.cardiologyonline.comFrom:cardiologyonlineViews:0 0ratingsTime:02:00More inScience Technology
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Study reveals genetic causes of a male infertility disorder
Public release date: 25-Oct-2012 [ | E-mail | Share ]
Contact: Elisabeth (Lisa) Lyons elyons@cell.com 617-386-2121 Cell Press
Severe spermatogenic failure (SSF) is a genetic condition that causes low sperm count and infertility. New insights into the genetic alterations that cause this disorder and their prevalence in populations of men around the world are provided by a study published by Cell Press in the American Journal of Human Genetics on October 25. The findings reveal which alterations are the greatest risk factors for the disease, and they could be immediately applicable in genetic counseling for assisted reproduction.
"Medically relevant population genetics studies are well established for most of the human genome, but this is the first study of this kind for the Y chromosome," says study author Steve Rozen of Duke-National University of Singapore Graduate Medical School. "This study let us determine for the first time that two types of deletions jointly account for 8% of severely low sperm count."
The most common known genetic causes of SSF are deletions in the Y chromosome's AZFc region. Six deletions in this region have been reported, but it was not known how prevalent they are in the general population or how much they increase the risk of the disorder. To answer these questions, Rozen and his collaborators screened for these six deletions in more than 20,000 men from India, Poland, Tunisia, Vietnam, and the United States.
The team detected four of the six previously described deletions, whose prevalence varied dramatically across populations, and identified one of these deletions as a strong risk factor for SSF. The most common deletionknown as gr/grwas found in about 2% of men as well as 2% of cases and almost doubled the risk of SSF. More notably, the rare b2/b4 deletion, found in well under 1% of men, increased the risk of SSF by a factor of 145 and accounted for about 6% of cases.
"Our study reveals that these two deletions are largely responsible for the AZFc region's contribution to SSF," Rozen says. "The immediate clinical use of these findings would be in genetic counseling, especially when a man with one of these deletions is using assisted reproduction to have a child."
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Rozen et al.: "AZFc Deletions and Spermatogenic Failure: A Population-Based Survey of 20,000 Y Chromosomes."
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Campus Connection: Nobel Prize winner to deliver public lectures at UW-Madison
University of Utah professor Mario Capecchi, co-winner of the 2007 Nobel Prize in physiology or medicine, will give free public talks on the UW-Madison campus both Monday and Tuesday.
Capecchis first lecture is Monday at 1 p.m. in room 1325 of the Health Sciences Learning Center, 750 Highland Ave. This event is geared toward students and the general public, and is titled, "The Making of a Scientist -- An Unlikely Journey."
The professor of human genetics and biology will give a second lecture directed to those in the scientific community titled, "Gene Targeting Into the 21st Century: Mouse Models of Human Disease from Cancer to Neuropsychiatric Disorders." This event is scheduled for Tuesday at 3:30 p.m. in room 2002 of Rennebohm Hall, 777 Highland Ave.
Capecchi earned the Nobel prize for developing so-called knockout mouse technology. This pioneering work allows researchers to pick out a gene in a mouse and then mutate it in a particular way that allows scientists to have an animal model to study a range of diseases and ailments.
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Campus Connection: Nobel Prize winner to deliver public lectures at UW-Madison
American Society of Human Genetics annual meeting to occur Nov. 6-10 in San Francisco
Public release date: 18-Oct-2012 [ | E-mail | Share ]
Contact: Cathy Yarbrough press@ashg.org 858-243-1814 American Society of Human Genetics
At ASHG 2012, scientists will present data revealing that:
In addition, the winner of CLARITY Challenge, the first international competition to accelerate development of lab-to-clinic standards for DNA sequencing of patients will be announced at ASHG 2012.
Mary-Claire King, Ph.D., ASHG president and professor of genome sciences and medicine at University of Washington, Seattle, will open ASHG 2012 on Tuesday, Nov. 6, with an address on, "The Scientist as a Citizen of the World."
A panel discussion on "Human Genetics 2012 and Beyond: Present Progress and Future Frontiers," will conclude the meeting on Saturday, Nov. 10.
The ASHG 2012 pressroom will spotlight the closing plenary session topic and the research presentations listed above through news releases, press briefings and press availabilities.
ASHG's news releases will be posted on EurekAlert! and the following password-protected ASHG site http://www.ashg.org/2012meeting/newsrls.shtml, which journalists can access by contacting press@ashg.org. Details about the press conferences & press availabilities will be posted on the ASHG site.
Over 6,000 scientists, medical geneticists and genetic counselors are expected to attend the ASHG 2012 meeting, the world's largest scientific conference on human genetics.
To register as press, journalists should visit: http://www.ashg.org/2012meeting/pages/press.shtml
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American Society of Human Genetics annual meeting to occur Nov. 6-10 in San Francisco
Seattle Genetics Announces Initiation of Phase II Trial of ADCETRIS® as Front-line Therapy for Hodgkin Lymphoma …
BOTHELL, Wash.--(BUSINESS WIRE)--
Seattle Genetics, Inc. (SGEN) today announced the initiation of a phase II clinical trial evaluating ADCETRIS (brentuximab vedotin) as a front-line therapy for patients age 60 or older with newly diagnosed Hodgkin lymphoma (HL). The trial is designed to assess the efficacy and tolerability of ADCETRIS as a monotherapy for older HL patients who have received no prior treatment. Seattle Genetics is the leader in the field of antibody-drug conjugates (ADCs) and ADCETRIS is an ADC directed to CD30 for relapsed HL and systemic anaplastic large cell lymphoma (sALCL).
The current standard of care for the treatment of front-line HL is a combination of multiple chemotherapeutic agents and has not changed in more than three decades. Some older HL patients are not able to tolerate the significant side effects associated with these regimens, and there is a significant need to identify effective and tolerable treatment options for these patients, said Thomas C. Reynolds, M.D., Ph.D., Chief Medical Officer at Seattle Genetics. We believe the response rate associated with single-agent use of ADCETRIS in the relapsed HL setting supports the evaluation of single-agent ADCETRIS in older patients who have received no prior therapy.
The phase II single-arm, open-label clinical trial will evaluate the efficacy and tolerability of ADCETRIS as front-line monotherapy in patients age 60 or older with HL. The trial is enrolling patients who are newly diagnosed and have received no prior HL treatment. The primary endpoint of the trial is to assess the objective response rate (ORR), with key secondary endpoints of safety and tolerability, duration of response, complete remission (CR) rate and progression-free survival (PFS). The study is expected to enroll up to 20 patients at multiple centers in the United States.
More information about the trial, including enrolling centers, will be available by visiting http://www.clinicaltrials.gov.
About ADCETRIS
ADCETRIS (brentuximab vedotin) is an ADC comprising an anti-CD30 monoclonal antibody attached by a protease-cleavable linker to a microtubule disrupting agent, monomethyl auristatin E (MMAE), utilizing Seattle Genetics proprietary technology. The ADC employs a linker system that is designed to be stable in the bloodstream but to release MMAE upon internalization into CD30-expressing tumor cells.
ADCETRIS received accelerated approval from the U.S. Food and Drug Administration (FDA) for two indications: (1) the treatment of patients with HL after failure of autologous stem cell transplant (ASCT) or after failure of at least two prior multi-agent chemotherapy regimens in patients who are not ASCT candidates, and (2) the treatment of patients with sALCL after failure of at least one prior multi-agent chemotherapy regimen. The indications for ADCETRIS are based on response rate. There are no data available demonstrating improvement in patient-reported outcomes or survival with ADCETRIS.
ADCETRIS is not approved for use outside the United States. The marketing authorization application for ADCETRIS in relapsed or refractory HL and sALCL, filed by Takeda Global Research & Development Centre (Europe), was accepted for review by the European Medicines Agency (EMA) in June 2011. In July 2012, the Committee for Medicinal Products for Human Use (CHMP) of the EMA issued a positive opinion for the conditional approval of ADCETRIS, supporting an approval decision in the European Union.
Seattle Genetics and Millennium are jointly developing ADCETRIS. Under the terms of the collaboration agreement, Seattle Genetics has U.S. and Canadian commercialization rights and the Takeda Group has rights to commercialize ADCETRIS in the rest of the world. Seattle Genetics and the Takeda Group are funding joint development costs for ADCETRIS on a 50:50 basis, except in Japan where the Takeda Group will be solely responsible for development costs.
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23andMe Names Christine Castro, Neil Rothstein and Jonathan Ward to Leadership Positions
MOUNTAIN VIEW, Calif., Oct. 16, 2012 /PRNewswire/ --Today 23andMe, the leading personal genetics company, announces the appointment of Christine Castro as Vice President Communications, Neil Rothstein as Vice President Marketing, and Jonathan Ward as Vice President Strategic Alliances joining the company's executive leadership team.
As Vice President, Communications, Chris Castro is responsible for the company's corporate communications, media relations and investor relations initiatives. Prior to joining 23andMe, Chris served as Senior Vice President, Corporate Relations, for Genentech, as well as Chief Communications Officer for Yahoo! Inc. and Vice President, Corporate Communications for The Walt Disney Company. Chris has a Bachelor of Arts degree in journalism and a Master of Arts degree in communications management, both from the University of Southern California.
As VP Marketing, Neil Rothstein is responsible for the marketing, branding and customer acquisition activities of the company. Prior to joining 23andMe, Neil worked at Netflix for 11 years most recently serving as VP, Online Marketing where he led the company's global online marketing activities across the US, Canada, Latin America, UK, and Ireland. Neil has also had roles withRateItAll, ESPN, and the Atlanta Committee for the Olympic Games. Neil received an MBA from the Gouizueta Business School at Emory University anda BA in Economics from Brandeis University.
Serving as Vice President, Strategic Alliances, Jonathan Ward is responsible for the company's strategic partnerships. Prior to joining 23andMe, Jonathan served most recently as interim Chief Marketing Officer at eHarmony.com and held a variety of marketing and business development roles during his eight-year tenure there. Jonathan has also held marketing and business development roles at America Online, McKinsey & Company as well as Ogilvy, Adams & Rinehart. Jonathan has a Bachelor of Arts degree in English from Williams College and holds a Masters in management from the J.L. Kellogg School of Management at Northwestern University.
"The addition of these seasoned executives to our management team is essential to helping us manage our growth and continuing to expand the consumer genetics market,"said Anne Wojcicki, 23andMe CEO and co-founder. "I am thrilled to be working with such an experienced and innovative team."
About 23andMe23andMe, Inc. is the leading personal genetics company dedicated to helping individuals understand their own genetic information through DNA analysis technologies and web-based interactive tools. The company's Personal Genome Service enables individuals to gain deeper insights into their ancestry and inherited traits. The vision for 23andMe is to personalize healthcare by making and supporting meaningful discoveries through genetic research. 23andMe, Inc., was founded in 2006, and the company is advised by a group of renowned experts in the fields of human genetics, bioinformatics and computer science. More information is available at http://www.23andme.com.
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23andMe Names Christine Castro, Neil Rothstein and Jonathan Ward to Leadership Positions
Human Life Span Took Huge Jump in Past Century
This article was updated at 7:19 p.m. ET.
Humans are living longer than ever, a life-span extension that occurred more rapidly than expected and almost solely from environmental improvements as opposed to genetics, researchers said today (Oct. 15).
Four generations ago, the average Swede had the same probability of dying as a hunter-gatherer, but improvements in our living conditions through medicine, better sanitation and clean drinking water (considered "environmental" changes) decreased mortality rates to modern levels in just 100 years, researchers found.
In Japan, 72 has become the new 30, as the likelihood of a 72-year-old modern-day person dying is the same as a 30-year-old hunter-gatherer ancestor who lived 1.3 million years ago. Though the researchers didn't specifically look at the United States, they say the trends are not country-specific and not based in genetics.
Quick jump in life span
The same progress of decreasing average probability of dying at a certain age in hunters-gatherers that took 1.3 million years to achieve was made in 30 years during the 21st century.
"I pictured a more gradual transition from a hunter-gatherer mortality profile to something like we have today, rather than this big jump, most of which occurred in the last four generations, to me that was surprise," lead author Oskar Burger, postdoctoral fellow at the Max Planck Institute for Demographic Research in Germany, told LiveScience.
Biologists have lengthened life spans of worms, fruit flies and mice in labs by selectively breeding for old-age survivorship or tweaking their endocrine system, a network of glands that affects every cell in the body. However, the longevity gained in humans over the past four generations is even greater than can be created in labs, researchers concluded. [Extending Life: 7 Ways to Live Past 100]
Genetics vs. environment
In the new work, Burger and colleagues analyzed previously published mortality data from Sweden, France and Japan, from present-day hunter-gatherers and from wild chimpanzees, the closet living relative to humans.
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Genetics Society of America Announces 2013 Award Recipients
Newswise BETHESDA, MD -- October 15, 2012 -- The Genetics Society of America (GSA) is pleased to announce its 2013 award recipients. The five individuals honored are recognized by their peers for their outstanding achievements and contributions to the community of geneticists. They will receive their awards at GSA conferences during 2013.
This years award winners are an outstanding group of individuals who have all contributed in such powerful ways to the field of genetics in research, in education, and in fostering the genetics community. The GSA awards provide an opportunity for the genetics community as a whole to say a heartfelt thank you and to recognize those whose impressive achievements have advanced the science of genetics, said Phil Heiter, PhD, President of GSA.
The recipients of the 2013 GSA Awards are as follows:
Thomas D. Petes, PhD (Duke University) is awarded the Thomas Hunt Morgan Medal for lifetime contributions in the field of genetics.
Elaine A. Ostrander, PhD (National Institutes of Health, National Human Genome Research Institute) is awarded the Genetics Society of America Medal for outstanding contributions to the field of genetics in the last 15 years.
R. Scott Hawley, PhD (Stowers Institute for Medical Research) is awarded the George W. Beadle Award for outstanding contributions to the community of genetics researchers.
A. Malcolm Campbell, PhD (Davidson College) is awarded the Elizabeth W. Jones Award for Excellence in Education, which recognizes significant and sustained impact in genetics education.
Jonathan K. Pritchard, PhD (HHMI and University of Chicago) is awarded the Edward Novitski Prize, which recognizes an extraordinary level of creativity and intellectual ingenuity in solving a significant problem in genetics research. Additional information about each of the awards and the recipients achievement is listed below.
Recipient: Thomas D. Petes, PhD, Duke University Award: The Thomas Hunt Morgan Medal
Dr. Petes is the Minnie Geller Professor in Genetics in the Department of Molecular Genetics and Microbiology at Duke University Medical Center in Durham, NC. He has made seminal research contributions that have furthered the understanding of the mechanisms of DNA damage and repair using the yeast Saccharomyces cerevisiae as a model system. His insights into comprehending genome stability and instability extend far beyond this model system, laying the foundation for much of our knowledge about how human cells replicate, protect, repair and combine their chromosomes. This has provided crucial understanding in identifying the gene defects of the most common form of hereditary colon cancer and in other human diseases.
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Myriad Genetics to Announce First Fiscal Quarter 2013 Results on Monday, November 5, 2012
SALT LAKE CITY, Oct. 15, 2012 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc. (MYGN) today announced that it will issue financial results for the first fiscal quarter 2013 following the close of market on Monday, November 5, 2012.
The Company will also host a conference call on Monday, November 5, 2012 at 4:30 P.M. Eastern to review the financial results. Participating on the call will be: Peter Meldrum, President and Chief Executive Officer, Mark Capone, President of Myriad Genetic Laboratories, Inc. and Jim Evans, Chief Financial Officer.
To listen to the call, interested parties may dial 800-354-6885 or 303-223-2680. All callers will be asked to reference reservation number 21607424.
The conference call will also be available through a live webcast at http://www.myriad.com.
A replay of the call will be available two hours after the end of the call for seven days and may be accessed by dialing 800-633-8284 or 402-977-9140 and entering reservation number 21607424.
About Myriad Genetics
Myriad Genetics is a leading molecular diagnostic company dedicated to making a difference in patient's lives through the discovery and commercialization of transformative tests to assess a person's risk of developing disease, guide treatment decisions and assess risk of disease progression and recurrence. Myriad's portfolio of molecular diagnostic tests are based on an understanding of the role genes play in human disease and were developed with a commitment to improving an individual's decision making process for monitoring and treating disease. Myriad is focused on strategic directives to introduce new products, including companion diagnostics, as well as expanding internationally. For more information on how Myriad is making a difference, please visit the Company's website: http://www.myriad.com
Myriad, the Myriad logo, BRACAnalysis, Colaris, Colaris AP, Melaris, TheraGuide, Prezeon, OnDose, Panexia and Prolaris are trademarks or registered trademarks of Myriad Genetics, Inc. in the United States and foreign countries. MYGN-F, MYGN-G
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Myriad Genetics to Announce First Fiscal Quarter 2013 Results on Monday, November 5, 2012
Petes Wins Lifetime Achievement Award in Genetics
By Duke Medicine News and Communications
Thomas D. Petes, PhD, has been named the 2013 recipient of the Thomas Hunt Morgan Medal for lifetime achievement in the field of genetics from the Genetics Society of America. Petes, the Minnie Geller Professor of Molecular Genetics and Microbiology at Duke University School of Medicine, specializes in the study of yeast as a model for understanding genomic instability and chromosomal abnormalities commonly found in cancer cells. "Tom Petes research on cell division in yeast has direct relevance for human cells and the proteins involved in DNA repair, with important implications for understanding genetic defects that cause cancer," said Nancy Andrews, M.D., PhD., dean of the Duke University School of Medicine. "It is a powerful example of how the most fundamental, basic science research can have tremendous importance for understanding and treating human diseases. Petes and his colleagues have discovered striking similarities between yeast and human cells in the structure and function of proteins involved in DNA repair and in the protection of the tips of chromosomes. The similarities have yielded new insight into how normal cells become cancerous. For example, yeast cells lacking particular DNA mismatch repair enzymes exhibit genetic instabilities also found in human colorectal cancer cells, a finding that suggested the repair defects might play an important role in the disease process. Notably, Petes was among the first to apply these findings to hereditary non-polyposis colon cancer, an inherited syndrome in which 80 percent of patients develop intestinal tumors. Petes predicted that afflicted patients might similarly have mismatch repair mutations. The Petes lab also identified a gene in yeast required for maintenance of the tips of chromosomes that was closely related to a human gene mutated in patients with the cancer-prone disease ataxia telangiectasia. "Dr. Petes' rigorous work over the years in a model organism, in this case, yeast, is a wonderful example of how studies of model organisms can inform us about mechanisms of human disease, in this case, cancer, said Michael B. Kastan, M.D., PhD, executive director of the Duke Cancer Institute and the William W. Shingleton Professor of Pharmacology and Cancer Biology. He is richly deserving of this award for a superior body of work." Petes received his PhD in genetics at the University of Washington in Seattle. He then went on to postdoctoral fellowships at the National Institute for Medical Research in London and the Massachusetts Institute of Technology in Cambridge. In 2002, Petes served as president of the Genetics Society of America, and was the chair of the Department of Molecular Genetics and Microbiology at Duke from 2004-2009. He has been a member of the National Academy of Sciences since 1999; was named to the American Academy of Arts & Sciences in 2005; and became a fellow in the American Academy of Microbiology in 2009. The Thomas Hunt Morgan Medal is awarded for lifetime contributions to the science of genetics. It recognizes the full body of work of an exceptional geneticist, and recipients have made substantial contributions throughout their careers. The Medal was established by the Genetics Society of America in 1981 and named in honor of Thomas Hunt Morgan, who received a 1933 Nobel Prize for his findings, which provided the first experimental evidence that chromosomes are the carriers of genetic information.
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Master-builder of the Human Genetics Unit
Walking up the stairs of the Faculty of Medicine, which reminded me of a colonial English Mansion with an imposing regal atmosphere, I finally found the Office of the Dean.
In his spacious office sat Professor Rohan W. Jayasekara, Dean of the Faculty of Medicine who is a pioneer in the field of Medical Genetics in Sri Lanka. He is the person who established the first Human Genetics Unit in the country in 1983. Professor Jayasekara appeared to be extremely affable with a most friendly disposition and he immediately put one at ease. This is his interview with Reminiscences of Gold.
Professor Rohan Jayasekara
I was born in Colombo and had my upbringing in Mount Lavinia. I was the only child in the family. The childhood I spent in the early 50s was a laid back setup where things moved at a leisurely pace. Children got their education but at the same time they enjoyed their childhood. School began at 8.45 am and finished at 3.15 in the afternoon. So after a good breakfast, we went to school with a lunch break of one hour from 12.15pm - 1.15pm. We could even play a cricket match continuing the next day. Classes finished at 3.15 pm and those who wanted to play sports could stay on in the college.
Others came home and played the usual cricket, rugby and football in our garden. All the neighbours were one family. My father was an old Peterite so he sent me to St. Peters. There was strict discipline at St. Peters but at the same time there was a lot of freedom and we had a proper moulding. I owe so much to my old school. The important thing during that era was that we didnt have television. I remember coming to the British Council very regularly because I used to finish two books every week. We developed our reading habits which helped improve our command of the language, explained Jayasekara.
He joined the Faculty of Medicine at the Peradeniya University in 1967 where he spent five years. Those were the best years of my life and it was one of the most beautiful universities in the world. We had a balanced life. We thoroughly enjoyed seeing plays in the Open Arts Theatre. There were very dedicated teachers and there were the likes of Professor Bibile who had musical evenings in their homes. It was an enriching experience. I always felt that the graduates of Peradeniya had a kindred spirit. Maybe because we lived together, ate and drank together, enjoyed, celebrated and cried together. The 1971 JVP insurrection was the only tragic experience we had. Some lost their lives.
Jayasekera joined the Faculty of Medicine as a lecturer in 1974. He left the island in 1977 for his postgraduate studies at the Department of Human Genetics, University of Newcastle upon Tyne. Its a beautiful university town with friendly people. We learnt not only the subject matter but also other character moulding traits: how to communicate with people, how to be polite and how to disagree with people and how to control oneself. I have never seen any British professional throwing tantrums. Not even under the harshest of provocations. I have never seen my boss losing his temper. They had a way about them.
I had a very interesting experience during my stay in England. Besides my Ph.D. certificate, I also have a certificate from the Chief Constable of Northern England, the equivalent of our IGP there because I helped them arrest red handed a gang of car thieves. I used to work on the fourth floor of the Human Genetics Unit from where I could see the car park. One day I looked down at the car park and saw my car there. Fifteen minutes later I noticed that my red car was missing. So I phoned the Police. A week later they came home and knocked on the door and the people in my flat thought that I had committed a crime. My car had been found in Glasgow because some football hooligans had taken it there. It had been full of empty bottles of beer. A few months later, when I was looking down at the car park, I saw some guys trying to open some cars in the car park. I quickly rang the cops, and in five minutes, four panda cars rushed in and they caught the thieves red handed. Then they came up to the fourth floor looking for Dr. J and I identified myself. Three weeks later I got a letter from the Chief of Police saying : we greatly appreciate your action which helped us in arresting the car thieves and breaking a ring of crime that has been going on there. My boss Professor Roberts said: Chum, this is more valuable than your Ph.D. certificate. I felt happy because I did something good for the community.
Jayasekara returned to the island in 1980 having obtained a Ph.D. in Cytogenetics, which was a pioneering field at the time. The study of Human Genetics has far-reaching consequences for the health of any nation. Jayasekara established the first Human Genetics Unit in the country in 1983. When I came back from England, I was determined not to waste my knowledge and skills so I decided to start the unit. With the initial assistance of the WHO, I managed to build it up. Now we have collaborations and link programmes with several institutes abroad. We conduct teaching programmes for other faculties, institutes and colleges.
We have trained five doctors as clinical geneticists. Now it can run on its own and it is quite independent. I dont even have to sight the place because it is running really well. Im blessed with good people. Now there are 30 people in the unit. Our biggest problem is the lack of space and that is the only constraint. We have an abundance of talent. People are enthusiastic and they need to be encouraged and nurtured. Our talent is unmatched anywhere in the world. So my ambition is to see that every main town has a Human Genetics Unit.
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Genetics at the heart of disease
A MAJOR study has identified 21 new genetic variants linked to cholesterol levels and the risk of heart disease.
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