Singer Jeremih leaves hospital after battling Covid-19 and thanks health care workers for saving his life – CNN

In a statement issued by his family, the 33-year-old entertainer thanked the staff at Chicago's Northwestern Memorial Hospital for keeping him alive.

"First and foremost I would like to thank God and the incredible team of doctors and nurses at Northwestern Memorial Hospital for saving my life," the statement, obtained by CNN Saturday, reads. "I will be forever grateful. I would also like to thank my family and friends for all their prayers and well wishes."

He said he also continues to thank the artists Chance The Rapper, 50 Cent and Diddy for "their love and support" and extends gratitude to his fans and people around the world who prayed for him.

"I'm getting stronger every day, and look forward to spending time with my sons," he said.

The singer/songwriter's first Top 10 hit was 2009's "Birthday Sex."

He's had more hits since and successful collaborations with other artists, including Ty Dolla Sign and YG.

CNN's Lisa Respers France contributed to this report.

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Singer Jeremih leaves hospital after battling Covid-19 and thanks health care workers for saving his life - CNN

COVID-19 vaccines set to arrive in Tennessee after months of uncertainty – Chattanooga Times Free Press

Tennessee's first shipment of COVID-19 vaccine is expected to arrive at 27 hospitals across the state around Dec. 19, and those most at-risk from the serious and deadly COVID-19 infection will begin to access the revolutionary new drugs.

Having a safe, effective vaccine on hand is a significant milestone and much-welcomed good news as the rapidly-spreading coronavirus that's so far killed nearly 270,000 Americans and more than 1.5 million people worldwide shows no sign of slowing. But public health experts know that injecting two doses of vaccine into the bodies of 4.8 million Tennesseans how many people it's estimated need to be vaccinated in order to ultimately control COVID-19 will not be easy.

"If we don't get about 70% of the population of Tennessee vaccinated against COVID-19, we don't stand a whole lot of a chance of moving beyond where we are right now with masks and distancing and holidays away from loved ones," Dr. Michelle Fiscus, medical director for the vaccine-preventable diseases and immunizations program at the Tennessee Department of Health, said during the state's COVID-19 Health Disparity Task Force meeting Thursday.

She said that although distributing COVID-19 vaccine will be a major undertaking for the department, it's something that officials have long anticipated.

"We have exercised for years the ability to vaccinate large numbers of individuals expecting what we thought would be a pandemic flu. It ends up that it's a pandemic coronavirus, but we know how to do this," Fiscus said.

To accomplish that goal, state and local officials will need to navigate complicated logistics, unexpected challenges and inevitable supply shortages. They will also be monitoring who gets the vaccine, tracking outcomes and trying to reach underserved populations with longstanding distrust for the health care system all while educating the public that getting vaccinated is in their best interest in the face of rampant misinformation on the internet and a raging pandemic.

"Vaccines are one thing. You got to get them in arms," said Mary Lambert, an advanced practice nurse and professor of epidemiology and public health policy at the Vanderbilt University School of Nursing who used to work at the U.S. Centers for Disease Control and Prevention.

"This is so different, just because of where we are in time and the social media aspect that influences so many things. The trust that individuals have in scientists and health care providers has been eroded just a bit," Lambert said. "We've got some work to do. I'm most concerned about getting the messaging out there how we do that, who's going to do that, and how soon we can get started? We probably should have started yesterday."

Fiscus said that the name "Operation Warp Speed" the partnership between the federal government and the private sector to accelerate development of COVID-19 vaccines and therapeutics works against those tasked with instilling confidence in the safety of vaccines. However, people need to understand that the scientific process for developing these vaccines was not rushed, she said.

"This is the same scientific process that we use for measles and mumps and chickenpox vaccines," Fiscus said. "What changed is that the manufacturing side has happened alongside of the science."

When drugs are developed under normal circumstances, Fiscus said they go through three phases of clinical trials in order to evaluate safety, effectiveness, side effects and outcomes. Then, funding the mass production process begins.

"This process can take years, especially because the risk part of this is in the manufacturing of these vaccines, and it can sometimes be very difficult to raise the capital to manufacture vaccines," she said.

In the case of Operation Warp Speed, the federal government took on that financial risk and began scaling up manufacturing from the start, so that when the research side was complete and the vaccine made it through all the safety checks, it could be immediately deployed.

Fiscus said Tennesseans can find additional comfort in knowing that by the time the first vaccine reaches the state, millions of people will already have received it because Pfizer's COVID-19 vaccine has already been approved in the United Kingdom with the first round of shipments on the ground.

"Which puts us at some nice advantage to be able to look and be further reassured from the data coming out of the United Kingdom that these vaccines are going to be safe," she said.

R. Alta Charo, a professor of law and bioethics at the University of Wisconsin at Madison, said during a webinar for science journalists last week that state and local officials need to anticipate confusion with the rollout.

"Officials have to be really open and transparent about why some groups go first and another doesn't, how they're making these decisions, and then, crucially, that these are not fixed in stone," she said. "These will change as new vaccines come online with different profiles for risk and benefit for different groups, as we see outbreaks here and there ... we need to recognize there will be change, and change doesn't mean we were wrong. It means that we are adapting on the fly as the situation changes, which is what a responsible health department would do."

After the U.S. Centers for Disease Control and Prevention issued new vaccination allocation guidance last week, Tennessee revised its distribution plan by moving up residents and staff in long-term care facilities, which have been hit especially hard by the virus.

(READ MORE: Infection rates soar at Hamilton County nursing homes as COVID-19 surge continues)

Fiscus said that she expects it will take "the better part of 2021" before vaccines are widely available for all Tennesseans, so even after they arrive, residents should prepare to keep social distancing, wearing face masks and avoiding crowds.

Contact Elizabeth Fite at efite@timesfreepress.com or follow her on Twitter @ecfite.

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COVID-19 vaccines set to arrive in Tennessee after months of uncertainty - Chattanooga Times Free Press

St. Simons Grandmother Takes A Shot In COVID-19 Fight | 90.1 FM WABE – WABE 90.1 FM

If big bad COVID-19 is ever to be knocked down, it just might take a plucky grandmother from St. Simons Island to do it.

But Diane Durand is no hero, she says. Just a determined woman who stood up and took a shot in the arm for the rest of us.

That shot contained a vaccine being developed in part by the Pfizer pharmaceutical giant to combat the virus that has spawned a crippling and deadly worldwide pandemic.

Durand, 75, was among 44,000 people who took part in Pfizers recent clinical trials to develop an effective vaccine to stop COVID-19.

Its what I wanted to do because I wanted to give back, Durand said Wednesday. I wanted to be a part of something positive.

Durand first learned about getting involved in the clinical trials from a friend who lives in Glynn County. The friend took part in the COVID-19 vaccine clinical trials conducted by the biotech company Moderna beginning in August.

So Durand obtained a number to call and reached out. After a phone interview with study organizers, Durand received a call back.

It was a selling point that I live on St. Simons, which has a high volume of tourist traffic, she said.

Durand made an appointment with the Encore Research Center in Jacksonville.

I met with a doctor who checked to make sure I was healthy, Durand said. And they took a blood sample to show I didnt have any antibodies in my system.

Because it is a blind test, Durand would not know in advance if she was receiving the vaccine or a placebo, she said. Even the folks at Encore Research did not know whether the shots were placebo or vaccine, she said.

Durand received her first shot in early September. She immediately developed a mild fever which, she said, is a strong indication of receiving the vaccine and not the placebo. The fever cleared the next day.

Im not one who sits around and waits for everybody else to do something, Durand said. I want us to get through this, and the only way to get through this is to all work together and do our part.

Durand is the mother and mother-in-law to Amanda and Palmer Fortune, proprietors of the popular Pier Village bistro, Palmers, as well as partners in The Porch restaurant nearby on the island. Social distancing and other preventive practices against the pandemic have caused financial strains for dining establishments and other service industry sectors.

Durand also has two young grandsons on St. Simons Island and a pair of young granddaughters in Tennessee. She would very much like to see a safe return to normalcy in society while they are all still young.

She said the facts and the science point to an effective vaccine against COVID-19 as the most direct path back to normalcy in society. But the vaccine will not work without the publics trust in it, she said.

People should not be afraid, she said. They should step up because a vaccine is only as good as the people who take it. If everybody doesnt take it, then were not going to get through this pandemic.

Durand received her second vaccine shot in October. She experienced no noticeable side effects other than the quickly subsiding fever.

I had an elevated temperature after each shot, she said.

Trial moderators took blood samples from Durand after she received each vaccine shot. Shortly after her participation in the trials, Durand had a blood sample drawn at a local clinic. The blood showed positive for antibodies, she said, proof that she received the vaccine rather than placebo.

Pfizer and its German partner BioNTech reported last month that the vaccine proved more than 90 percent effective in stopping COVID-19 during the trials.

The European Union said this week it hopes to approve the vaccine before the end of the year. In America, Pfizer hopes to hear from the U.S. Food and Drug Administration as early as Dec. 10 on its request to authorize the vaccine in emergency cases.

Vaccines traditionally employ inactivated doses of the offending virus to teach the bodys immune system to recognize and defend against the threat.

This new vaccine employs genetic strands called mRNA to produce proteins endemic to the virus, which in turn triggers the bodys immune system to defend against the virus, according to the CDC.

I wanted to be part of the solution, Durand said. Also I wanted to know what was really going on. Im tired of the misinformation and people being afraid. This process takes all of us working together. I had a very small part in this. But I had a part.

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Identifying depression in the elderly during COVID-19 – WJHL-TV News Channel 11

JOHNSON CITY, Tenn. (WJHL) Depression can be an overlooked health concern for many, but especially in the elderly community.

Since 2020 has been a tough year for everyone, Kristen Gallant explains how its specifically impacted the elderly who are in nursing homes and havent been able to see their families and friends.

Covid-19 has forced everyone to stay home more so than normal, leaving many people who are high risk for the virus cooped up inside and isolated.

This includes not being able to go to nursing homes or see older family members who may be living alone.

One organization is trying to raise awareness for mental health in the elderly community.

This is probably one of the hardest years of our seniors lives, said Kathryn McDonald, the Director of Jeb Foundation.

Waving from outside windows and calling those we love has become the only way to connect with those who are in assisted living facilities.

My heart goes out to anybody thats feeling depressed right now and especially people in senior citizens homes that arent able to see their family or their friends, and I know how difficult that must be, said Amber Boyd.

During the holiday season, the longing to be with family and friends grows even greater, as its a time usually spent surrounded by loved ones.

Boyd has fought with her own mental health battles, especially in the midst of Covid-19.

Ive struggles with depression off and on and post-partum, and I think everybody can agree that this year has been tough, and so weve been dealing with that the best we can and one of the best ways is getting outside and walking and moving, Boyd explained.

This is why the JEB Foundation in Johnson City is bringing awarness to senior citizens and their mental health by hosting a Steps for Seniors walk.

The walk started on East Tennessee State Universitys campus and ended at the Watauga Square Living Center.

It started in 2017, said McDonald. I really wanted to accentuate what I was already doing. So, I was already in the health care field connecting with seniors and as I connected with more individuals I saw the need of empowering those who are suffering from depression.

For Boyd, dealing with her own mental health gives her compassion for those who are struggling,

I think the biggest thing that has helped me is to be thankful, and on my headrest days when I woke up and didnt want to get out of bed, I just started making a list of things I was thankful for.

Other members who participated in the walk could join virtually or in person.

Mcdonald said JEB is an acronym for her mothers initials, Jane English Brown, and that she was walking in support of her mother and other seniors in the community.

Depression doesnt look the same in everyone, McDonald explained. Depression isnt always sadness. A lot of individuals that I have met with have experienced depression physically where they may be having panic attacks and they dont understand what theyre feeling.

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Identifying depression in the elderly during COVID-19 - WJHL-TV News Channel 11

Floridas 1 million COVID-19 cases are not as bad as you think | Letters – Tampa Bay Times

Florida virus cases top 1M | Dec. 2

The focus this week on the one-millionth COVID-19 case in Florida is expected from the Tampa Bay Times, but needs a little perspective. If you look at the other side of the equation, this number means that over the roughly 10 months of the pandemic, about 95 percent of Floridians have not tested positive for the virus. And 99.9 percent of Floridians have not died of COVID-19.

While we would all prefer no deaths and no infections, the current surge in infections in states like California that have had statewide mask mandates and endured significant lockdowns shows that it is not possible. So maybe Floridas approach to managing the virus by protecting the vulnerable while preserving the economy is not as bad as you think.

Barry Butler, Tarpon Springs

Fire commissioner arrested in spat over mask in Keys | Dec. 4

The East Lake Fire Commissioner arrested in Key West should wear his mask as prescribed period. His actions display his sense of personal entitlement, which he feels is greater than protecting fellow citizens or the friends he was visiting. I dont believe what his wife is saying, that there were hundreds of people not wearing masks at the time. Yesterday, in a local Walmart shopping center, four people during my shopping had no masks on. Employees were wearing their masks under their noses, and no one working in the store cared about enforcing the mask rule.

It amazes me how many grown people think mask-wearing doesnt apply to them. Thankfully, some sense will be returning to the White House soon. President-elect Joe Biden is already calling for 100 days of mask-wearing when he takes office. January 20 cant come fast enough.

Ron Kaiser, Gulfport

Fire commissioner arrested in spat over mask in Keys | Dec. 4

Like Tammy Dalrymple and presumably her husband, James, I too am distressed that this is what our country is coming to. But my distress is for a different reason. It seems that more and more people are putting their own self-interest and comfort ahead of concern and respect for the community. Wearing a mask is not that difficult.

John Doellinger, Wimauma

Reconsider highway projects | Editorial, Dec. 2

When the Florida Department of Transportation and the M-CORES task forces released their final reports, I was disappointed to not see the no build option adopted. While the final report for the Southwest-Central connector makes mention of guiding principles to protect the panther and habitat connectivity, the report misses the mark. How are you going to protect the panther and ensure its recovery when 34 percent of the study area is panther habitat? The proposed guiding principles and instructions are not sufficient to protect Floridas wildlife and waterways, and they put the remnants of wild Florida at risk of being paved over by the construction of these roads and the sprawl they will bring. Florida is home to many important and unique water features, such as our aquifers, the Green Swamp, and the greater Everglades ecosystem.

The proposed toll roads are unnecessary and will only induce harm onto Floridas unique wildlife and waterways. As Floridians, we must prioritize protecting our iconic state animal and unique ecosystems over development. We need to repeal the roads and exit from this proposal all together.

Gabrielle Gonzalez, Sarasota

Hospitals: Were vaccine-ready | Dec. 4

Since there will be limited doses of the vaccine for awhile, the following people and groups should be at the very back of the line for receiving the vaccine. Our governor and other politicians who refused to model good behavior by defying reasonable U.S. Centers for Disease Control and Prevention guidelines for mask-wearing and social distancing. Private citizens who also refused to put public health at the forefront to limit the spread of the virus. Sports professionals and other athletes who jumped the line to get tested even though many medical professionals and front line workers could not easily get tests. Seems only fair for them to wait their turn.

J.M. Romano, Clearwater

Is Florida doing better on coronavirus than locked down states? | Politifact, Dec. 3

In a well-written article, Politifact writers Louis Jacobson and Amy Sherman do a good job fact-checking Gov. Ron DeSantis claims regarding Floridas success on COVID-19. Yet, while they provide a large breadth of information, I feel as though their respectable quest for objectivity resulted in the omissions of some key details that better place DeSantis comments in context.

First and foremost, DeSantis has said this before. Think back to March, April, and even May, when Fox News and other conservatives were parading Florida and Texas around as success stories of how to handle COVID-19. We saw how that turned out. Even in late June, when the virus was beginning to ravage Florida in its first wave, he was attempting to point out that some parts of the country were seeing 50-60 percent positivity rates in March and early April.

These recent comments are nothing more than DeSantis attempt to shift blame, once again, from himself and the President Donald Trump machine.

Grant Edick, Hartsdale

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Floridas 1 million COVID-19 cases are not as bad as you think | Letters - Tampa Bay Times

Blood Tests Of Immune Response May Be Key To Future COVID-19 Vaccine Development : Shots – Health News – NPR

News of a good immune response in animals bodes well for testing future COVID-19 vaccines. CMB/Getty Images hide caption

News of a good immune response in animals bodes well for testing future COVID-19 vaccines.

News today from Harvard's Center for Virology and Vaccine Research may help solve a problem that future COVID-19 manufacturers are sure to face: how to make sure that new and potentially better vaccines actually work without doing extremely large and expensive studies.

Writing in the journal Nature, the researchers show that a certain class of antibodies in a monkey's blood predicted protection from COVID-19. If that hold true for humans, a relative simple blood test may show whether an experimental vaccine is working.

Here's the dilemma: Once a vaccine is approved, it's unethical to test it against a placebo. Approving new vaccine would require researchers to compare two vaccines against each other, instead of having a vaccine and a placebo--which would take a lot more people than the 30,000 for the initial trials.

Most researchers agree the key to solving this problem is finding something known as correlates of immunity.

"Correlates of immunity are very important because they give us insight into how vaccines work, says Dan H. Barouch, M.D., Ph.D., Principal Investigator at the Harvard vaccine center.

The idea is if you could measure something in a people's blood that would show whether a vaccine works or not, you could then focus more on whether the vaccine was safe--because researchers would already know it's likely effective.

"So it would be much more convenient for future testing of 19 vaccines to have a well-established correlate of protection," Barouch says.

This approach is already used in approving the annual flu vaccine. "There's a new influenza vaccine that's licensed every year," he says, because of genetic changes in the influenza virus.

"It would not be possible to do a large-scale clinical efficacy trial of an influenza vaccine candidate every single year," says Barouch, so regulators rely on correlates of protection.

The correlate of protection for the coronavirus vaccine, Barouch and his colleagues found, was neutralizing antibodies. These are antibodies that can prevent a virus from infecting cells. It's possible to test for the presence of these antibodies in people's blood.

It's been assumed all along that neutralizing antibodies were necessary for a vaccine to induce to be effective, but no one know for sure if neutralizing antibodies alone were enough.

The new research conducted with rhesus macaque monkeys suggests they are.

Researchers took blood from monkeys that had been infected with the coronavirus that causes COVID-19, and then recovered. That blood contained neutralizing antibodies to the coronavirus that helped the monkeys fight off the infection.

"We isolated [those antibodies], we purified them and then we transfer them alone into nave animals," Barouch says. Nave animals are ones who had never been sick.

They then exposed the monkeys to the coronavirus. Most showed no signs of infection, and of those receiving a higher amount of antibodies, none showed signs of infection.

The implication is if a vaccine can induce someone's immune system to make those antibodies, that alone might be sufficient to believe the vaccine will work. Some scientists have argued that vaccines must provoke other kinds of immune responses known a cellular immunity. This research suggests that might not be the case.

There are some caveats. The study was done in a small number of monkeys. Also, it's possible that human neutralizing antibodies won't work as well as the monkey neutralizing antibodies did.

Nonetheless, Barouch is bullish about the implications of this research. "This is good news for vaccines because this level of neutralizing antibodies should be readily achievable by a variety of different vaccine candidates," says Barouch.

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Blood Tests Of Immune Response May Be Key To Future COVID-19 Vaccine Development : Shots - Health News - NPR

Covid live updates: San Francisco Bay Area sets stay-at-home order; CDC says some reinfection is expected – CNBC

Ford delays Bronco SUV to summer 2021 due to Covid-related supply chain issues

Ford's new 2021 Bronco lineup -- four- and two-door Bronco models and the Bronco Sport (left to right) -- displayed at an off-road course on Aug. 11, 2020 in Michigan.

Michael Wayland / CNBC

Ford Motoris delaying the launch of its upcoming Bronco SUV to the summer of next year due to coronavirus-related problems in its supply chain, reports CNBC's Michael Wayland.

Customers who had reserved vehicles were expected to begin the ordering process Monday. That has now been delayed until mid-January, Ford spokesman Jiyan Cadiz told CNBC.

The postponement is a troubling sign for Ford as the 2021 Bronco is one of its most highly anticipated vehicles in years. As part of the delay, customers will now have until March 19 to place their order and agree to a final price, Cadiz said. Also, a highly anticipated "Sasquatch package" with manual transmission has been pushed back to the 2022 model year.

Supplier problems have not impacted the Bronco Sport, a vehicle currently arriving in dealerships that's part of Ford's new "Bronco family" of vehicles.

Melodie Warner

Fri, Dec 4 20205:17 PM EST

The New York Young Republican club hosted a large indoor gala in Jersey City, NJ, Thursday night with almost no mask-wearing or social distancing. New Jersey Gov. Phil Murphy blasted the group on Twitter, saying, "It is beyond the pale that anyone would willingly endanger people in another state."

New Jersey allows indoor gatherings of up to 150 people for religious and political activities protected by the First Amendment but requires attendees at indoor events to wear face coverings and stay six feet part. Photos and videos from the event posted on social media showed that gala attendees did not follow state guidelines for mask-wearing or social distancing.

Gov. Murphy said, "Jersey City law enforcement is investigating this matter." The Jersey City Police Department did not respond to requests for comment.

The event was first slated to take place in Manhattan, drawing criticism from New York Gov. Andrew Cuomo and New York City councilmembers.

Hannah Miao

Fri, Dec 4 20205:13 PM EST

President-elect Joe Biden said another round of coronavirus stimulus checks for U.S. families "may be still in play."

"I think it would be better if they had the $1,200 [payments to families]," Biden said when asked at a press conference to respond to criticism about a new Covid relief plan revealed this week as a starting point for the latest round of negotiations on Capitol Hill.

Biden added: "And I understand that may be still in play."

House Speaker Nancy Pelosi, D-Calif., and Senate Minority Leader Chuck Schumer, D-N.Y., have backed a bipartisan $908 billion relief plan as a basis for talks with Senate Majority Leader Mitch McConnell, R-Ky. The proposal does not include a second $1,200 direct payment to most Americans.

Biden has endorsed the plan as a "good start," but he has promised to push for more aid when his administration takes charge. At the press conference, Biden would not say if he has spoken to McConnell.

On Friday, Pelosi told reporters "there is momentum" toward lawmakers striking a deal.

Kevin Breuninger and Jacob Pramuk

Fri, Dec 4 20204:41 PM EST

The U.S. State Department drew criticism from the American Foreign Service Association surrounding large indoor holiday events scheduled at the agency. The Centers for Disease Control and Prevention cautions against indoor gatherings, as they have a greater risk for Covid-19 spread than outdoor events.

Secretary of State Mike Pompeo and other State Department officials have planned several indoor holiday parties, including one with at least 900 guests invited,The Washington Post reported. A week prior, State Department leaders told employees to avoid hosting in person gatherings and opt for virtual events.

"We urge the Department to reverse course and model responsible behavior in accordance with its own guidelines," AFSA said.

A spokesperson for the State Department said the events will follow health precautions including requiring masks, social distancing and temperature checks. The spokesperson did not provide guidance on how the agency would enforce mask-wearing while food and beverages are provided at the events.

The White House also plans to host at least 20 indoor holiday parties, according toNBC News. Several events at the White House, including an election night celebration and President Donald Trump's nomination of Justice Amy Coney Barrett, have led to dozens of coronavirus cases.

Hannah Miao

Fri, Dec 4 20204:33 PM EST

A stay-at-home order has been issued by heath officials in the San Francisco Bay Area, ahead of Gov. Gavin Newsom's statewide mandate. The six jurisdictions will all implement the order starting between Dec. 6 and Dec. 8 and lasting until Jan. 4.

Newsom on Thursday announced a regional, tier system though which areas would enter strict stay-at-home measures once ICU bed availability fell below 15%. San Francisco Mayor London Breed and the neighboring counties said Friday they wouldn't wait to hit that capacity threshold.

"If we wait, we are just delaying the inevitable," Breed said at a news conference. "If we wait one or two more weeks to have these restrictions placed on us, it will just mean our numbers will be higher and harder to bring down."

Under the order, outdoor dining, hair and nail salons, playgrounds, bars, theaters, museums, zoos will all close. Retail will remain open but will be capped at 20% capacity, and restaurants are permitted to offer takeout and delivery only.

Sara Salinas

Fri, Dec 4 20203:51 PM EST

A small child wearing a mask sits on her fathers shoulders outside of the Lenox Health Greenwich Village hospital during the nightly 'Clap Because We Care' cheer for medical staff and essential workers on May 29, 2020 in New York City.

Alexi Rosenfeld

Children and young teens could get a Covid-19 vaccine in the second half of next year, according to a CDC advisor.

"I don't think we're going to see it in the first half of this coming year," said Dr. Jose Romero, the chair of the Advisory Committee for Immunization Practices, an outside group of medical experts that advises the CDC. "We need to see how the studies progress. We need to see that data in order to make sure that it is safe and effective in children."

Vaccines can not be distributed to children until it's been rigorously tested in them in clinical trials.

Pfizer is already testing its vaccine on kids 12 and older. Moderna is preparing to test at least 3,000 children as young as 12, according to a posting on clinicaltrials.gov. Moderna CEO Stephane Bancel told CNBC on Monday that testing on very young children wouldn't begin until sometime next year.

"For younger children, you have to go down in age very slowly and you have to start at a lower dose to make sure it is safe," he said during an interview on "Squawk Box."

Berkeley Lovelace Jr.

Fri, Dec 4 20202:34 PM EST

Congress is trying to scrape together a coronavirus stimulus plan and government funding bill in the next week as the job market weakens and financial lifelines are set to expire.

House Speaker Nancy Pelosi said "there is momentum" toward a relief agreement. She spoke to Senate Majority Leader Mitch McConnell for the first time in at least a month, and both leaders want to attach aid provisions to a funding bill Congress needs to pass by Dec. 11.

At the same time, Pelosi, Senate Minority Leader Chuck Schumer and President-elect Joe Biden all said a weaker-than-expected November jobs report increases the urgency to send more help to Americans.

Congressional leaders still have multiple issues to resolve in order to pass both an aid bill and a funding plan. Relief sticking points include unemployment insurance, state and local government aid and liability protections for businesses.

About 12 million people will lose jobless benefits at the end of the month.

Jacob Pramuk

Fri, Dec 4 20202:10 PM EST

The Centers for Disease Control and Prevention quietly revised its estimates for the disproportionately deadly toll that Covid-19 is taking on communities of color, now reflecting a much higher burden than previously acknowledged.

After adjusting for age, which is a standard means of measuring disease impact, Hispanic and Black Americans are shown to die at a rate of almost three times that of White Americans, the CDC now says. The agency previously said Hispanic and Black Americans were dying at a rate of about one and two times higher than Caucasians, respectively.

Dr. Leana Wen, formerBaltimore health commissioner, said it's important that people understand it's not that the virus is discriminating against communities of color.

"I hope that people will see that it's not the virus that's doing the discriminating," she said in a phone interview. "It's our systems."

Will Feuer

Fri, Dec 4 20201:50 PM EST

Recent data suggests people who were once infected with the coronavirus could be infected again as their antibody response wanes, Dr. Mike Ryan, executive director of the World Health Organization's health emergencies program, said during a press briefing.

According to the U.S. Centers for Disease Control and Prevention, some Covid-19 reinfections are expected based on the agency's prior experience with similar viruses. In late August, researchers in Hong Kong reported what appeared to be the first confirmed case of Covid reinfection. While rare, the WHO said at the time that reinfection could be possible.

Maria Van Kerkhove, head of the WHO's emerging diseases and zoonosis unit, said that researchers are still trying to determine how long an antibody response lasts after someone is naturally infected with the virus.

"In some people, it may wane after a few months but we do get a good indication that natural infection immune response is lasting for some months," Van Kerkhove said.

Noah Higgins-Dunn

Fri, Dec 4 20201:35 PM EST

U.S. President-elect Joe Biden speaks during an event to name his economic team at the Queen Theater December 1, 2020 in Wilmington, Delaware.

Alex Wong | Getty Images

President-elect Joe Biden said Friday's underwhelming jobs report foreshadows a "dark winter" that demands "urgent action" from President Donald Trump and Congress.

Biden's statement on the latest report on the U.S. labor market came as Covid spreads out of control across the U.S. and Americans face benefit cuts if Congress does not pass stimulus legislation.

"This is a grim jobs report. It shows an economy that is stalling," Biden said.

Jobs increased by 245,000 in November, well below the 440,000 expected by economists and a sharp drop from the 610,000 reported in October.

The statement noted that the "dire jobs report" only offered a snapshot of the situation in November, "before the surge in COVID cases and deaths in December as we head into a dark winter."

Still, Biden said he was "encouraged" by progress being made on Capitol Hill, where congressional leaders are signaling "momentum" in the protracted negotiations over an additional pandemic relief bill.

Kevin Breuninger

Fri, Dec 4 20201:06 PM EST

Workers assists guests at check-in during the reopening of Bellagio hotel-casino on June 4, 2020, in Las Vegas.

Ronda Churchill | AFP via Getty Images

Friday's jobs report showed a weakening U.S. labor market, and for the hard-hit hospitality industry, job growth was relatively flat. The sector, which faced the steepest losses in the spring, remains down by 3.4 million jobs compared to February levels.

Wendy Edelberg, an economist with the Brookings Institution, said that without extensions to government aid that expires at the end of the year, there's a good chance consumer spending will drop and more small businesses like restaurants and bars will close, which could lead to fewer hospitality jobs being available.

Real-time data from restaurant reservations serviceOpenTable show bookings at their lowest levels since August, and job search site ZipRecruiter has seen a significant decline in restaurant and hotel job postings in recent days. That could indicate that more hospitality job losses are on the horizon in the winter months ahead as the coronavirus outbreak intensifies.

Fri, Dec 4 202012:52 PM EST

The restaurant industry lost 17,400 jobs in November, marking the first month since April that food and drinking places have seen employment shrink.

States and municipalities began placing restrictions on eateries and bars once again in October and November as the number of new Covid-19 cases surged. The overall unemployment rate for the industry was 13.8% in November.

In addition to job losses, November also saw the restaurant industry's same-store sales fall to 10.3%, its biggest drop since August, according to data from Black Box Intelligence.

Amelia Lucas

Fri, Dec 4 202011:26 AM EST

Former New York Stock Exchange President Tom Farley told CNBC he had a "nasty case" of Covid-19 in March during the early days of the coronavirus pandemic.

"I had a 102 to 103.5 [degree] fever for 15 days straight, and then I couldn't get out of bed for another week. I lost about 25 pounds," Farley said on "Squawk Box," adding that he "cracked a tooth from chattering."

His illness came as his blank-check company was in the process of finalizing an acquisition with Global Blue, a Swiss fintech firm.

"My brain wasn't firing. I was physically exhausted. It was not a good period in my life," said Farley, whose second special purpose acquisition company began trading on the NYSE this week. "On that 23rd day, I woke up and, yes, I was weak but I felt better and I felt hopeful and optimistic, and I started getting into a workout routine."

Farley also acknowledged he was fortunate to have recovered from the disease. "I almost feel guilty talking about this, given how many people have died," he said.

Kevin Stankiewicz

Fri, Dec 4 202010:41 AM EST

The Centers for Disease Control and Prevention on Wednesdayunveiled new quarantine guidancethat allows some people to restrict their contact with others for less than the recommended 14-day period under certain circumstances.

The new advice was created to try to boost compliance with the quarantine guidelines, but some public health experts say the nation's premier health agency was trying to solve the wrong problem. Instead of focusing on why people aren't adhering to the guidelines, the agency focused on the rules themselves, which undermined the risk of exiting quarantine before 14 days, epidemiologists said.

"I think the recommendations are based on an idea that there are people who see 14 [days] as the rule and say, 'I can't do 14,' so I'm not going to do any at all, and [the CDC] wants those people to know that seven [days] would be better than nothing," Ellie Murray, an epidemiologist at Boston University, said. "But I don't think that's how the message is getting out."

Will Feuer

Fri, Dec 4 202010:13 AM EST

A host greets a diner at a Cheesecake Factory Inc. restaurant in the Canoga Park neighborhood of Los Angeles, California.

Patrick T. Fallon | Bloomberg | Getty Images

The Cheesecake Factory is the first company to be charged by the Securities and Exchange Commission for misleading investors about the financial impacts of the coronavirus pandemic.

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Covid live updates: San Francisco Bay Area sets stay-at-home order; CDC says some reinfection is expected - CNBC

A full table at Christmas this year may mean an empty one in the years ahead, experts warn – USA TODAY

We asked you to tell us your biggest questions about the COVID-19 vaccines. Here are some answers. USA TODAY

Choose to keep chairs empty at the holidaysthis year or risk having them empty for yearsto come. That's the message being delivered in various forms by public health experts and politicians as COVID-19 continues to spread at a devastating pace.

The promise of an effective vaccine being widely available in 2021 means holidaygatherings are expected to beless risky next yearand beyond,a hopeful future that could provide a pandemic-weary nation the resolve to scale down their celebrations this year.

Your actions today are going to protect Christmas next year ... you dont want to have empty seats where grandma (and other relatives) used to be," Gleb Tsipursky, who holds a Ph.D. in the history of behavioral science, told USA TODAY.

But even with the nation's hospitals filling up, many Americans are primed to make risky decisions this December they will regret for years to come, saidTsipursky,CEO of Disaster Avoidance Experts and author of a book about adapting to"the new abnormal" of COVID-19.

It doesn't have to be that way especially if Americans make an effort to adjust their thinking and expectations, experts told USA TODAY.

Part of the problem, as Tsipursky sees it: Good news surrounding a vaccine hascreated a disorienting mix of long-term hope amid increasing short-term danger all at the moment Americans facepressure to gather with loved ones this holiday season.

That jumble of information tends to confuse people and can lead many to make bad decisions,Tsipursky said. In situations like this, humans tend to throw out the bad news and focus on short-term joy.

Compounding the problem: Pandemic-weary Americans are starved for pleasure,MelanieGreenberg, a clinical psychologistand author of "The Stress-Proof Brain,"told USA TODAY. That can lead people to over-value it,making comfortingholiday rituals seem more appealing than ever, despite their danger this year.

COVID hospitalizations pass 100,000: Experts fear weary staff will be 'overrun' by patients

The long-term outlook for the course of the pandemic has rapidly improved in recent weeks, giving Americans a luxury they haven't had for months: Confidence that things will soonget better.

Just weeks ago,Tsipursky told USA TODAY he expected the pandemic to only slowly improve over the course of years. But surprisingly effective results from vaccine candidates since then have improved his predictions.

With that good news, Tsipursky encouraged Americans to indulge in planning for an amazing holiday season next year.

Make Christmas 2021 the best youve ever had," he said. Its going to be so much better. COVID is going to be behind us."

That's the model followed by Dr. Anthony Fauci, who said said hes most likely scrapping Christmas plans this year as he didfor Thanksgiving.

For my own family, Im saying we had a really great Thanksgiving and Christmas last year. Were looking forward to a really great Thanksgiving and Christmas in 2021, the director of the National Institute of Allergy and Infectious Diseases previously told USA TODAY.

But a happy holiday season next year hinges on family members staying healthy a joyfulfuture that should motivate millions of Americans to stay safe this holiday season,Greenberg suggested.

What would next Christmas be like if someone got sick?Greenberg asked. She encouraged having that possibility to mind when making decisions this holiday season.

Nov. 24: After months of following COVID-19 guidelines, a Texas family 'let their guard down' for a day. All 12 of them got sick.

InBelgium, one of the hardest-hit nations in the world,the country's prime minister also invoked the dark "empty chair" example, asking the nation toleave a chair empty atChristmas dinneror face the possibility of having that chair empty forever.

Greenberg suggested that physical reminders can be powerful motivators for people trying to avoid risky behavior in the holiday season and beyond.

One idea: Have a physical reminder of future plans.Plan travel for late in 2021and print out the tickets. Keep a picture of vulnerable family members around and imagine a happy, healthy holiday season next year.

A safe holiday season doesn't mean totally depriving yourself of joy,Greenberg said. Everyone shouldthink about the level of risk they are willing to take how much short-term pleasure is worth the possibility of long-term consequences.

There are ways of minimizing risk if families choose to gather, although some areas of the country may have more strict regulations. In general,health experts are recommendingholding events outdoors, limiting their size, having participants wear masks and maintaining social distance as strategies to minimize risk this year.

But such sacrifices are not easy,Greenberg acknowledged: You have to keep two concepts in your mind a the same time: the present and the future.

Contributing:Michael Collins, Maria Puente,Adrianna Rodriguez and Jorge L. Ortiz, USA TODAY; The Associated Press

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A full table at Christmas this year may mean an empty one in the years ahead, experts warn - USA TODAY

3674 new COVID-19 cases and 14 deaths reported by Utah health department Saturday – KSL.com

SALT LAKE CITY There are 3,674 new test-confirmed cases of COVID-19 and 14 new deaths from the disease Saturday in Utah, according to statistics released by the Utah Department of Health.

The health department also reports that 603 Utahns are currently hospitalized due to COVID-19, 212 of them in intensive care units, and that 14,838 more people were tested for the virus.

Overall, the updated numbers bring Utah to 212,844 confirmed cases, 939 reported deaths and 8,765 coronavirus-related hospitalizations since the COVID-19 pandemic began.

In an email, the health department said the 14 reported deaths included 10 women:

They also included four men, all of whom were residents of a long-term care facility:

Of the state's 939 deaths, 330 of them about 35% have been long-term care facility residents. Salt Lake County and Utah County together account for 62% of the state's COVID-19 related deaths.

Over the past week, the state has averaged 2,958 new reported cases per day and a positive test rate of 25.5%.

There is no COVID-19 news conference from state leaders scheduled for this weekend; Gov. Gary Herbert and health officials addressed the public during a news conference on Thursday. During the conference, Herbert anticipated a Thanksgiving-related uptick in coronavirus cases but hoped the number wouldn't increase "too dramatically."

State epidemiologist Dr. Angela Dunn also provided new guidelines on how to quarantine after possible exposure to the virus. The state now recommends Utahns quarantine for 10 days instead of 14, or potentially as few as seven days if they are tested that day, receive a negative result and aren't showing symptoms. The new guidelines match ones recently unveiled by the Centers for Disease Control and Prevention.

Test results now include data from PCR tests and antigen tests. Positive COVID-19 test results are reported to the health department immediately after they are confirmed, but negative test results may not be reported for 24 to 72 hours.

The total number of cases reported by the Utah Department of Health each day includes all cases of COVID-19 since Utah's outbreak began, including those who are currently infected, those who have recovered from the disease, and those who have died.

Recovered cases are defined as anyone who was diagnosed with COVID-19 three or more weeks ago and has not died.

Deaths reported by the state typically occurred two to seven days prior to when they are reported, according to the health department. Some deaths may be from even further back, especially if the person is from Utah but has died in another state.

The health department reports both confirmed and probable COVID-19 case deaths per the case definition outlined by the Council of State and Territorial Epidemiologists. The death counts are subject to change as case investigations are completed.

For deaths that are reported as COVID-19 deaths, the person would not have died if they did not have COVID-19, according to the health department.

Data included in this story primarily reflects the state of Utah as a whole. For more localized data, visit your local health district's website.

More information about Utah's health guidance levels is available at coronavirus.utah.gov/utah-health-guidance-levels.

Information is from the Utah Department of Health and coronavirus.utah.gov/case-counts. For more information on how the Utah Department of Health compiles and reports COVID-19 data, visit coronavirus.utah.gov/case-counts and scroll down to the "Data Notes" section at the bottom of the page.

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3674 new COVID-19 cases and 14 deaths reported by Utah health department Saturday - KSL.com

Fantasy football is a billion-dollar pastime. Covid-19 is wreaking havoc with it – CNN

It's also made for the wildest season yet of fantasy football, and this billion-dollar business and its legions of devotees have had to get creative to make it work.

It can feel like a frivolous pursuit at a time when the pandemic is claiming so many lives, but to enthusiasts fantasy football is a welcome distraction from the sobering realities of 2020.

For those who don't play, it works like this: You draft football players from across the NFL to play on your own virtual team. The better they play in real NFL games, the more points they score for your fantasy team in head-to-head matchups with other teams in your league.

This means that every fantasy football team "owner" needs to keep up with stats, schedules and injuries in order to do well.

During a normal season, that's a complex task. This season, it's an all-out scramble.

The NFL has postponed games, fantasy leagues have added new contingencies and fantasy managers have been forced to juggle lineups to replace players who've tested positive for Covid-19.

Coronavirus is throwing football season into chaos

Take the last few weeks of the NFL alone:

Experts say it's made fantasy football more challenging

With so many things muddling up the season right now, you'd think fantasy football fans would be throwing in the towel. But one expert thinks it's just created exciting new challenges.

"Nothing is simple in 2020, broadly speaking. This has been a year that has impossible to plan ahead for anything, and that piece has forced us to really live in the moment in so many ways." she says.

"But this has presented an opportunity to fantasy football enthusiasts and diehards to really challenge themselves. If they win this year, they can say to themselves, 'I've really done some mental and strategic gymnastics, and I've earned this.'"

Fantasy football is the kind of niche passion that can either inspire intense 45-minute conversations or make people's eyes glaze over at the first mention of a roster deadline. But anyone who's had to adjust plans on the fly or fight for little joys during this stressful year will recognize the struggles and triumphs of fantasy football devotees.

"This hobby, in a time where not much else is happening, is a brilliant distraction," Loza says. That's one of the reasons she thinks there's been a spike in interest in fantasy sports. "This fall and winter, you're probably going to be staring at the ceiling at 3 a.m. a lot," she says, "and you might as well be doing it while thinking about your fantasy roster."

The fantasy football industry has been forced to adapt

Like the NFL, these sites have been scrambling to adjust.

On Yahoo's popular show "Fantasy Football Live," of which Loza is a part, cast members have had to get used to a new virtual set. Analysts have created new statistics to help fans create plans for their fantasy teams, and team owners have had to make contingency plans to keep their lineups from imploding when games are postponed or players are quarantined.

And, danger and disappointments aside, this unprecedented football season may be leading people to appreciate sports in a way they may not have before.

"The things that I love most about sports regardless of gender, age, race, creed, is we love the stories -- we love something we learned about the human condition," Loza says.

And as long as games keep being played and players stay safe, fantasy football team owners will be along for the ride -- no matter how bumpy it may get.

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Fantasy football is a billion-dollar pastime. Covid-19 is wreaking havoc with it - CNN

San Francisco 49ers lineman Trent Williams says COVID-19 battle was ‘toughest thing I ever had to do’ – ESPN

SANTA CLARA, Calif. -- San Francisco 49ers left tackle Trent Williams has faced no shortage of challenges in more than a decade in the NFL.

In 2019 alone, Williams was diagnosed with a rare cancer and had to have a tumor removed from his skull. He also missed that entire season as he and the Washington Football Team remained in a dispute over the handling of his health and his contract status.

According to Williams, none of it compared to his recent battle with COVID-19.

"It was the toughest thing I ever had to do in my career," Williams said Saturday. "Not only did I have, what, 14 days of literally nothing [to do], but I spent that time battling COVID. It wasn't just sitting on the couch and having iced lemonade and just enjoying the newspaper. It was stressful times because you just never know how that's gonna affect you. Nobody knows until it actually runs its course."

Williams tested positive for the coronavirus soon after a Nov. 15 loss to the New Orleans Saints. From there, Williams, who is not only a cancer survivor but also asthmatic, said he felt the effects of COVID-19 on his body for the next seven or eight days.

Because the 49ers were on the bye week as Williams dealt with symptoms, he did not miss a game. By last Thursday, Williams was feeling better and was told that he would have a chance to play against the Los Angeles Rams. He was cleared to play last Saturday and started Sunday.

Williams said one of the symptoms he dealt with was respiratory, which made him a bit leery since he hadn't had any practices in two weeks to get his wind up for the game against the Rams.

"I honestly didn't expect to play," Williams said. "That's a pretty good time period, but I have great teammates, great coaches. They helped me get through it."

Nearly three weeks removed from his COVID battle, Williams is keeping perspective and remaining thankful that he was able to get through it without more serious complications.

"Just coming off of the year I had in '19 where things didn't really go my way, I was kind of expecting this COVID deal to take the same turn," Williams said. "But luckily, I'm blessed, I got through it with little to no effect from it now.

"I'm just thankful because I know there's a lot of people out there who battled this virus and it didn't end so well for them. I never want to overlook that, but the last couple years have been pretty challenging. But I'm standing here, so I'm blessed."

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San Francisco 49ers lineman Trent Williams says COVID-19 battle was 'toughest thing I ever had to do' - ESPN

COVID-19: Two heath workers, 10 others contract virus in Ondo

The Ondo State Government has said 12 new cases of the Covid-19 infection have been recorded in the state.

Two of the number are health workers from Akoko South East local government area.

The Acting Commissioner for Health in the State, Jibayo Adeyeye, gave the details while addressing journalists in Akure on Wednesday.

According to him, four cases were recorded in Akoko South-East, three from Akure South, one from Ile Oluji/ Okeigbo; one from Ose, one from Owo, one from Idanre and one in Okitipupa.

He also noted that seven of them were asymptomatic.

He said Ondo has a total of 1651 confirmed COVID-19 cases; with 25 active confirmed cases and 36 deaths.

In spite of this, the Governor of the state, Oluwarotimi Akeredolu, has approved the resumption of all schools in the state on Monday, 19th of October, 2020.

He, however, directed that all schools must abide by the COVID-19 preventive guidelines released by the Ondo State Inter-ministerial Committee to ensure the safety of staff and students.

Chairperson of the Inter-ministerial Committee on Coronavirus (COVID-19), who is also the Vice-Chancellor, University of Medical Sciences, Ondo, Adesegun Fatusi, said that the governor had also instructed the Ondo State Inter-ministerial Committee to conduct periodic monitoring visit to schools and any school found not to be complying with the COVID-19 guidelines should be shut.

The guidelines include: Notices with the message, No Mask, No Entry, must be boldly displayed at the entrance of the school and at strategic spots throughout the school compound; Infrared thermometer must be made available and used to assess the temperature of each staff, student, and visitors at the point of entry into the schools.

Hand washing devices with an adequate and constant source of running water and soaps must be available in schools and all individuals must wash their hands when entering the schools. Alternatively, hand sanitisers with an alcohol content of not less than 70% may be used.

All individuals with high temperature or who show any form of illness must not be allowed into the school: written guidelines must be available in that regard.

Seats in the classrooms and staff rooms must be separated with a minimum space of two metres or 6 feet (two arms length).

A COVID-19 monitoring team must be established in each school with the responsibility for monitoring and ensuring full compliance of all staff and students with the above-stated guidelines.

Civil society organisations, which monitored the just concluded governorship election in the state, observed widespread non-compliance with COVID-19 protocols as directed by the Independent National Electoral Commission.

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Could certain COVID-19 vaccines leave people more vulnerable to the AIDS virus? – Science Magazine

CanSino Biologicss experimental COVID-19 vaccine is one of at least four using an adenovirus that some worry could increase HIV susceptibility.

By Jon CohenOct. 19, 2020 , 6:30 PM

Sciences COVID-19 reporting is supported by the Pulitzer Center and the Heising-Simons Foundation.

Certain COVID-19 vaccine candidates could increase susceptibility to HIV, warns a group of researchers who in 2007 learned that an experimental HIV vaccine had raised in some people the risk for infection with the AIDS virus. These concerns have percolated in the background of the race for a vaccine to stem the coronavirus pandemic, but now the researchers have gone public with a cautionary tale, in part because trials of those candidates may soon begin in locales that have pronounced HIV epidemics, such as South Africa.

Some approved and experimental vaccines have as a backbone a variety of adenoviruses, which can cause the common cold but are often harmless. The ill-fated HIV vaccine trial used an engineered strain known as adenovirus 5 (Ad5) to shuttle into the body the gene for the surface protein of the AIDS virus. In four candidate COVID-19 vaccines now in clinical trials in several countries, including the United States, Ad5 similarly serves as the vector to carry in the surface protein gene of SARS-CoV-2, the viral cause of the pandemic; two of these have advanced to large-scale, phase III efficacy studies in Russia and Pakistan.

In todays issue ofTheLancet, four veteran researchers raise a warning flag about those COVID-19 vaccine candidates by recounting their experience running a placebo-controlled AIDS vaccine trial dubbed STEP.An interim analysis of STEP found that uncircumcised men who had been naturally infected with Ad5 before receiving the vaccine became especially vulnerable to the AIDS virus. The vaccine, made by Merck, had been the leading hope for what was then a 20-year search for a shot that could thwart HIV. But after the STEP results appeared, the field went into a tailspin. It took a decade to recover, says one of the co-authors of theLancet correspondence, Lawrence Corey of the Fred Hutchinson Cancer Research Center.

Corey, who now co-leads the COVID-19 prevention network in the United States that is testing vaccines at the behest of the National Institutes of Health, says he and his co-authors went public because Ad5-based COVID-19 vaccines may soon be tested in populations with high HIV prevalence and thus a greater risk of accidental infection during a clinical trial. If I were in a sub-Saharan African country and making a decision as to what I would want for my country for a general population use of a SARS-CoV-2 vaccine, I dont see why I would pick an Ad5 vector [vaccine] when there are many other alternative choices, Corey says.

The backfire in STEPwhich evaluated the efficacy of the Merck vaccine in people at high risk of HIV infection in the Americas and Australiaalso appeared in a second study, dubbed Phambili, of the same vaccine. It was taking place simultaneously in South Africa and was stopped early because of the STEP data.

Precisely how Mercks Ad5 vaccine increased the risk of HIV transmission in STEP and Phambili remains murky. The Lancet editorial spells out several possibilities, including dampening of HIV immunity, enhancing replication of the AIDS virus, or setting up more target cells for it.

In addition to the Ad5 COVID-19 vaccine candidates, several other leading vaccines, including ones made by Johnson & Johnson and AstraZeneca/the University of Oxford, use different adenoviruses as vectors. Theres no evidence that any of those adenoviruses increases the risks of an HIV infection.

I dont see why I would pick an Ad5 vector [vaccine] when there are many other alternative choices.

Of the Ad5-based COVID-19 vaccine candidates, from China-based CanSino Biologics, has developed the furthest. In a Lancet report in May, researchers from the company recognized the controversial possibility of their vector increasing the risk of HIV infection and said they would watch for it in the candidates trials. CanSinos COVID-19 vaccine is being tested in efficacy trials in Russia and Pakistan that together hope to enroll more than 40,000 people, and the company is discussing starting studies in Saudi Arabia, Brazil, Chile, and Mexico.

China has already approved a CanSino vaccine against Ebola that uses the Ad5 vector. Yu Xuefeng, CanSinos CEO, tells Science the risk of increased HIV susceptibility may be limited to Ad5 vaccines that produce an AIDS virus protein. Theres no clear answer yet, Yu says. We certainly havent seen anything with the Ebola vaccine. The companys Ebola vaccine was tested in a population in Sierra Leone that, he notes, had a relatively high HIV prevalence, making it more likely to have detected the problem if it existed.

Russias Gamaleya Research Institute has a COVID-19 vaccine candidate that uses a combination of Ad5 and Ad26 vectors; its now in an efficacy trial in that country.

Last week, ImmunityBio received approval from the U.S. Food and Drug Administration to begin human trials of its COVID-19 vaccine, which uses Ad5 as a vector. The first trial will take place in Newport Beach, California, but Patrick Soon-Shiong, the companys CEO, says he also hopes to test it in South Africa, where he grew up and went to medical school.

He calls the STEP study results very, very fuzzy and stresses that ImmunityBios Ad5 has four deleted genes that reduce the immune responses it triggers. Its 90% muted, he says.

ImmunityBio is discussing the risks with scientists and regulators in South Africa of a trial there to test its modified Ad5 COVID-19 vaccine. The informed consent process for that proposed study would tell participants about potential risks given the previous STEP and Phambili results.

Soon-Shiong emphasizes that his companys experimental COVID-19 vaccine, unlike every other candidate that uses an adenovirus vector, presents two different SARS-CoV-2 genes and mighttherefore offer more protection from infection or disease. Why only test this in wealthy enclaves of Southern California, he asks? Why not South Africa? Why not for the underserved people of the world?

Pediatrician Glenda Gray, who heads the South African Medical Research Council and was the protocol chair of Phambili, has taken part in several discussions with the ImmunoBio team.When [Soon-Shiong] contacted South Africa, we were obviously quite concerned, Gray says. All of us who were in Phambili and quite traumatized by what happened asked whether there was an appetite to do something in South Africa.

But after several months of deliberations, the South Africans concluded that regulators should consider a small trial of the vaccine there in people at low risk of HIV infection, Gray says. We decided not to throw the baby out with the bath water just yet, she adds. If it does go ahead in South Africa, there has to be huge consultation with communities, and we have to make doubly sure that the participants understand what happened in the past.

Gray says South Africa appreciates ImmunoBios offer to allow the country to manufacture the product. Were in the middle of a COVID-19 epidemic in South Africa, and we dont know if well ever get access to the current suite of vaccines produced elsewhere, she says.

The decision to move forward, she insists, has to be left to South African scientists, regulators, and ethics committees. Its incredibly patronizing for people to determine what science is good or bad for other countries, she says. Everyone knows about Phambili and STEP, and the scientists understand that theres an important need to be cautious.

Gray, who has co-authored papers about HIV vaccines with Corey and the other three authors of the Lancet correspondence, says there are no easy answers. What if this vaccine is the most effective vaccine? she asks. If this works out to be an important vaccine, well have some experience with it.

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Could certain COVID-19 vaccines leave people more vulnerable to the AIDS virus? - Science Magazine

Live Covid-19 Updates: The Latest Globally – The New York Times

Heres what you need to know:New Jersey Gov. Phil Murphy is advising residents against non-essential out-of-state travel.Credit...Noah K. Murray/Associated Press

Coronavirus cases in New Jersey, an early epicenter of the pandemic, are on the rise again, doubling over the last month to an average of more than 900 new positive tests a day, a worrisome reversal of fortune for a state that had driven transmission rates to some of the nations lowest levels.

After an outbreak several weeks ago in a heavily Orthodox Jewish town near the Jersey Shore, cases are now rising in counties across the state, driven, officials say, by indoor gatherings.

The states health commissioner has said there are signs of widespread community spread for the first time since New Jersey successfully slowed the spread of a virus that has claimed the lives of more than 16,000 residents. A small, densely packed state, New Jersey has the highest virus fatality rate in the country.

Gov. Philip D. Murphy said Monday that residents should refrain from all but necessary out-of-state travel.

The numbers are up, Mr. Murphy said. Theyre up up and down the state.

Under a quarantine policy adopted by New Jersey, New York and Connecticut, New Jersey now exceeds the threshold an average of 10 cases for every 100,000 residents for seven days used to determine which states should be included in the travel advisory. Thirty-eight other states are on the list.

The uptick comes as other parts of the Northeast and states across the country are confronting similar surges of infections and hospitalizations as the pandemic stretches into its eighth month, with a death toll that now exceeds 219,000, according to a New York Times database.

Mr. Murphy, who has been conservative in allowing the state to reopen, said he would consider targeted shutdowns to curb the spread, as Connecticut and New York have done, but he suggested that would not cure the problem.

As the coronavirus pandemic erupted this spring, two professors at Stanford University Dr. Jay Bhattacharya and Dr. Scott W. Altas bonded over a shared concern that lockdowns were creating economic and societal devastation.

Now Dr. Atlas is President Trumps science adviser, a powerful force inside the White House. And Dr. Bhattacharya is one of three authors of the so-called Great Barrington Declaration, a scientific treatise that calls for allowing the coronavirus to spread in order to achieve herd immunity the point at which enough people have been infected to stall transmission of the pathogen.

The Centers for Disease Control and Prevention and leading experts have recently concluded, using different scientific methods, that as many as 90 percent of Americans are still vulnerable to infection.

While Dr. Atlas and administration officials have denied advocating the herd immunity approach, they have praised the ideas in the declaration. The message is aligned with Mr. Trumps vocal opposition to lockdowns on the campaign trail, even as the country grapples with renewed surges of the virus.

The central proposition is that to contain the coronavirus, people who are not vulnerable should immediately be allowed to resume life as normal while those at high risk are protected from infection.

Under that scenario, younger Americans should return to workplaces, schools, shops and restaurants, while older Americans would remain cloistered from the virus as it spreads, recipients of such services as grocery deliveries and medical care.

It argues that eventually so many younger Americans will have been exposed, and presumably will have developed some immunity, that the virus will not be able to maintain its hold on the communities.

The manifesto does not contain details on how the strategy would work in practice, nor do its authors have expertise in implementing public health programs. Dr. Anthony S. Fauci, the governments top infectious disease expert, dismissed the declaration as unscientific, dangerous and total nonsense, as well as unethical, particularly for multigenerational families and communities of color.

The idea has alarmed and angered other public health researchers. On Wednesday, about 80 published a manifesto of their own, the John Snow Memorandum (named after a legendary epidemiologist), saying that this approach would endanger one-third of the U.S. population who have conditions that put them at high risk from severe Covid-19, and result in perhaps a half-million deaths.

I think its wrong, I think its unsafe, I think it invites people to act in ways that have the potential to do an enormous amount of harm, said Dr. Rochelle Walensky, an infectious disease expert at Harvard University and one of the signatories to the Snow memo. You dont roll out disease you roll out vaccination.

President Trump attacked Dr. Anthony S. Fauci, the governments top infectious disease expert, in a conference call on Monday with campaign aides, calling the doctor a disaster and saying, People are tired of hearing Fauci and these idiots, all these idiots who got it wrong.

He continued his criticism of Dr. Fauci, the overwhelmingly popular director of the National Institute of Allergy and Infectious Diseases, after landing in Arizona for the first of two scheduled rallies in the state, which is experiencing a rise in coronavirus cases.

Speaking to reporters after deplaning Air Force One, Mr. Trump called Dr. Fauci a very nice man but complained that he loves being on television and has made a lot of bad calls. Asked why he didnt fire Dr. Fauci, Mr. Trump said, Hes been there for about 350 years. I dont want to hurt him.

At a campaign rally on Monday in Arizona, where polls show that the president is trailing Mr. Biden, Mr. Trump also faulted the news media for excessive coverage of the coronavirus.

Theyre getting tired of the pandemic, arent they? Mr. Trump said in Prescott, in central Arizona. You turn on CNN. Thats all they cover. Covid, Covid, pandemic, Covid, Covid.

The attack on Dr. Fauci comes as the United States has seen more coronavirus cases over 8 million and more deaths nearly 220,000 than any other nation in the world. The presidents advisers have tried to get him to lay off the infectious diseases specialist, who remains popular.

Dr. Fauci pushed back against complaints that he had flip-flopped over the use of masks, saying that admitting a mistake after examining further data shows honesty.

The conflict began Sunday night on the CBS News program 60 Minutes, when Dr. Fauci said it was absolutely no surprise that President Trump got sick with the coronavirus, given his lax attitude toward social distancing guidance.

I was worried that he was going to get sick when I saw him in a completely precarious situation: crowded, no separation between people and almost nobody wearing a mask, Dr. Fauci said in the CBS interview. He was referring to an event at the White House in September to announce the nomination of Amy Coney Barrett for the Supreme Court.

When I saw that on TV, I said, Oh, my goodness, nothing good can come out of that thats got to be a problem, Dr. Fauci said. Sure enough, it turned out to be a super-spreader event.

Numerous people who attended the event later tested positive for the coronavirus, including the president.

Dr. Fauci, who has often been at odds with the president, sharpened his stance against an ad run by Mr. Trumps re-election campaign that appeared to show the doctor praising the presidents handling of the coronavirus. Dr. Fauci said his words were taken out of context, and that their use in the ad was inappropriate because he never endorses candidates.

I got really ticked off, he said.

Mr. Trumps attacks on Dr. Fauci led Senator Lamar Alexander of Tennessee to become the latest Republican to distance himself from the president. Dr. Fauci is one of our countrys most distinguished public servants, said Mr. Alexander, who is retiring this year. He has served six presidents, starting with Ronald Reagan. If more Americans paid attention to his advice, wed have fewer cases of Covid-19, and it would be safer to go back to school and back to work and out to eat.

The National Academy of Medicine honored Dr. Fauci on Monday with the academys first Presidential Citation for Exemplary Leadership, citing his distinguished service as a trusted adviser to six U.S. presidents during public health crises and steady leadership during the Covid-19 pandemic.

In his acceptance speech, Dr. Fauci said that to inspire public trust and confidence in vaccines, people needed to hear consistent messages from the government, not conflicting ones.

A judge in Wisconsin, the site of the one of the worst outbreaks of a resurgent coronavirus, has upheld an executive order by Gov. Tony Evers that limits public gatherings to 25 percent of a building or rooms capacity.

This critically important ruling will help us prevent the spread of this virus by restoring limits on public gatherings, said the governors office in a statement. This crisis is urgent. Wisconsinites, stay home.

The ruling means in rural Wisconsin, many restaurants, taverns, and supper clubs with no maximum capacity set by local authorities will be limited to ten patrons dining-in at a time, according to the Tavern League of Wisconsin, which requested a temporary injunction on Emergency Order #3 from the circuit court judge.

The state has reported more than 22,500 new coronavirus cases in the last week, according to a New York Times database, putting Wisconsin behind only North Dakota, South Dakota and Montana in terms of new infections per capita.

The Tavern League, which sued for relief against the executive order, represents about 5,000 small businesses, according to Scott Stenger, who heads the leagues government affairs outreach. We dont take suing anybody lightly, let alone the governor of our state, Mr. Stenger said. Its not something wed do before.

Mr. Stenger said the league had not been consulted ahead of time about the emergency order, and did not have an opportunity to help craft regulations that might better help eateries and bars across the rural parts of the state stay open while still taking precautions to protect their customers.

The issue is especially acute in rural areas of Wisconsin, where there are often no set capacity limits for restaurants and taverns. By default, those businesses will be limited to ten patrons.

Without economic assistance from the state, or from Congress, Mr. Stenger said that more of his members will likely go out of business.

California will have its own independent panel of experts review any federally approved coronavirus vaccines before they are administered to residents, Gov. Gavin Newsom said on Monday.

Of course we wont take anyones word for it, he said in a news briefing. He emphasized that the second set of eyes on potential vaccines is part of Californias broader efforts to make sure that vaccines get equitably distributed to communities that are most vulnerable.

While Mr. Newsom acknowledged that the vaccine approval process has been politicized, he said, It doesnt matter who the next president is, were going to maintain our vigilance.

The announcement came after Gov. Andrew M. Cuomo of New York said that his state would also review vaccines approved by the federal government although Mr. Cuomo tied the move to doubts raised when President Trump suggested that he would reject tougher F.D.A. guidelines. Frankly, Im not going to trust the federal governments opinion, Mr. Cuomo said in late September.

On Sunday, Mr. Cuomo, as head of the bipartisan National Governors Association, posed additional questions about how the Trump administration will ensure that states are able to get and distribute vaccines.

Mr. Newsom said that his state is working with the federal government on its vaccination plans, but that experts from Californias prestigious academic and health care institutions are helping to figure out expected logistical challenges. They include where to store vaccines that must be kept cold, how to notify people about when to get their second shots and how to guarantee that rural communities have access to vaccines.

Mr. Newsom cautioned against being overly exuberant about the prospect of widespread vaccination; he said that wont happen until next year. This vaccine will move at the speed of trust, he said.

Californias new case rates have stayed relatively low, even as the state has expanded testing and gradually lifted restrictions on businesses. Still, the governor implored residents not to let their guard down as the holidays approach.

Countries across Europe announced new restrictions on Monday in an effort to halt a strong second wave of the virus, as the global tally of cases passed 40 million. Cases have been detected in nearly every country around the world, and at least 1.1 million people have died.

Officials are desperate to avoid a second economically damaging blanket lockdown, and are instead seeking to tighten restrictions in a more precise fashion. Heres the latest.

Ireland will be imposing its highest level of restrictions starting on Wednesday night, Prime Minister Michael Martin announced on Monday. Nonessential businesses will be mandated to close, restaurants and pubs will be limited to takeout, and people will not be allowed to travel more than five kilometers (three miles) from their homes. Schools and construction sites will remain open, however, the public broadcaster RTE reported. The restrictions, which will remain in effect for six weeks, come after the country set new daily case records four times in the past week. If we pull together over the next six weeks we will be able to celebrate Christmas in a meaningful way, Mr. Martin said.

In Spain, the region of Navarre announced on Monday the countrys most drastic regional measures yet to contain the second wave. As of Thursday, Navarre will stop its residents from leaving their region except for work or emergency reasons. It will also close for 15 days its bars and restaurants, and force all shops, sports venues and other establishments to close by 9 p.m. The measures come after Navarre reported an average of 945 cases per 100,000 inhabitants over the past 14 days, three times the national average.

Austria, which reported 1,121 daily cases of the virus on Monday, announced new limits on the number of people who could meet privately starting Friday: six indoors and 12 outdoors. The country has reported nearly 10,000 cases in the past week, more than at any time in March, when the government imposed a nationwide lockdown. The restrictions were lifted over the summer as numbers dropped and the country sought to attract tourists, an important source of income for the alpine nation.

In Italy, Prime Minister Giuseppe Conte announced that mayors will have the power to close streets or squares where people tend to gather after 9 p.m., while restaurants, bars and pubs will be allowed to serve seated customers up to six per table until midnight. Drinking outside of restaurants or bars will be permitted only until 6 p.m., and gaming and betting halls will close at 9 p.m. Italy has so far fared better than its European counterparts, but infections have been rising in recent weeks, with a record 11,705 new cases reported on Sunday.

France imposed a nightly curfew in nine cities, including Paris, over the weekend, and asked people throughout the country to limit gatherings to six people to halt an alarming spike in cases. On Monday, the office of President Emmanuel Macron announced that the first lady, Brigitte Macron, was in quarantine after being exposed to someone who had tested positive. Ms. Macron has not shown any symptoms, the office said in a statement.

Slovenias government declared a 30-day state of emergency after cases of the virus more than doubled in the past week, Reuters reported. The government will ban movement between regions that have been most affected by the pandemic and introduce a nightly curfew beginning at 9 p.m. starting Monday, Interior Minister Ales Hojs said at a news conference. Mr. Hojs said that all public and religious events would be banned, and that the number of people allowed to gather would be reduced to six from 10. Slovenia has reported 4,845 coronavirus cases in the past week, a spike from 2,255 cases the week before.

Britain has reported an average of nearly 17,000 new cases a day over the past week, according to a New York Times database, with almost a thousand new daily cases in Wales.

Wales will enter a national lockdown starting Friday night, the countrys first minister, Mark Drakeford, announced on Monday. The firebreak lockdown, which will last until Nov. 9, will require residents to remain at home and force pubs, restaurants and nonessential shops to close. Mr. Drakeford said there are no easy choices in front of us and called the lockdown our best chance of regaining control of the virus and avoiding strain on the National Health Service.

About 2.3 million of the 3.1 million people in Wales were already living under local lockdowns. and the country has effectively shut its borders to travel from other parts of Britain.

And officials in Bucharest, the Romanian capital, announced that schools, theaters and indoor dining will be closed for at least two weeks, and that masks will become mandatory in all public spaces. The city reported on Sunday that the virus rate over the previous 14 days had exceeded three cases per 1,000 residents, a red line for imposing stricter rules. After keeping the virus largely in check during the initial months of the pandemic, Romania has seen cases triple over the past month. While the schools will switch to online learning, there is deep concern that many students lack tablets and other necessary materials.

As the Trump administration has pressed publicly for top-speed development and approval of a coronavirus vaccine, while researchers and public health experts warned of the dangers of rushing the process, the idea of getting the vaccine as soon as it is available is losing appeal for many Americans, especially Black Americans, recent surveys show.

In a STAT-Harris poll of about 2,000 people, conducted Oct. 7-10 and published Monday, 58 percent of respondents said they would get vaccinated right away, down from 69 percent who said the same in August.

The decline was twice as steep among Black respondents: just 43 percent said in October that they would get the vaccine, down from 65 percent in August.

Rob Jekielek, managing director of The Harris Poll, which has been asking the question throughout the pandemic, said two news events appeared to have played a role in the falloff: the back-and-forth between the Food and Drug Administration and the White House over vaccine guidelines, and President Trumps Covid-19 diagnosis and treatment.

The politicization of the process is having a huge negative effect, especially with Black Americans, he said in an interview.

Pew Research Center polls that framed a question on the issue somewhat differently also found growing hesitation over a vaccine: About 51 percent of adult respondents said in September that they would definitely or probably get a vaccine if one were available, down from 72 percent who said the same in May. The surveys included more than 10,000 respondents and had a margin of sampling error of plus or minus 1.6 percentage points.

Its pretty clear the public is concerned about the pace of the vaccine approval process and have outstanding questions about safety, said Alec Tyson, associate director of Pew Research.

Polls conducted for CNN by the market research firm SSRS asked, If a vaccine to prevent coronavirus infection were widely available at a low cost, would you, personally, try to get that vaccine, or not? Sixty-six percent of respondents said yes in May; just 51 percent did in October. The polls margin of error was plus or minus 3.3 percentage points.

And in an ABC News/Ipsos poll last month, 64 percent of respondents said they would take a safe and effective coronavirus vaccine, down from 74 percent in May. Those polls had a margin of error of 4.9 points.

For months, as New York City struggled to start part-time, in-person classes, fear grew that its 1,800 public schools would become vectors of coronavirus infection.

But nearly three weeks into the in-person school year, early data from the citys first effort at targeted testing has shown the opposite: a surprisingly small number of positive test results.

Out of 15,111 staff members and students tested randomly by the school system in the first week of its testing regimen, the city has gotten back results for 10,676. There were only 18 positives: 13 staff members and five students.

And when officials put mobile testing units at schools near Brooklyn and Queens neighborhoods that have had new outbreaks, only four positive cases turned up out of more than 3,300 tests conducted since the last week of September.

New York City is facing fears of a second wave of the virus brought on by localized spikes in Brooklyn and Queens, which have required new shutdown restrictions that included the closure of more than 120 public schools as a precaution.

On Monday, Mayor Bill de Blasio said that city continued to see a leveling off in those areas and officials had seen particular progress in central Queens, the mayor said. But he did not provide data for those areas.

Across the city, the seven-day average positivity rate was at 1.62 percent, the mayor said. When he first announced an uptick in cases about three weeks ago, the positivity rate was 1.38 percent.

Shortly afterward on Monday, Gov. Andrew M. Cuomo said that data in different hot spot areas across the state where he had imposed restrictions by zones would continue to be reviewed, and that the state would announce changes to the zones on Wednesday. Zone sizes could be made larger or smaller, he said, adding that we have total flexibility in these zones.

Statewide, the daily positivity rate was 1.21 percent, he said, while the red zones, which have the most severe restrictions in place, had a positivity rate of 3.31 percent. Hospitalizations statewide, which have been steadily increasing in recent weeks, are 934.

But for now, at least, New York Citys sprawling system of public schools, the nations largest, is an unexpected bright spot as the city tries to recover from a pandemic that has killed more than 20,000 people and severely weakened its economy.

In September, New York became the first big urban district to reopen schools for in-person learning.

Roughly half of the citys students have opted for hybrid learning, where they are in the building some days, but not others. The approach has enabled the city to keep class sizes small.

Over the last two weeks, Catholic leaders in New York have voiced their deep disapproval with Gov. Andrew M. Cuomo over his decision to sharply limit attendance at houses of worship in areas that are seeing a surge of new coronavirus cases.

The governors decision was largely aimed at trying to rein in congregants in Orthodox Jewish synagogues in New York City and in Orange and Rockland Counties, where some members have flouted social distancing and mask regulations.

But it also affected other houses of worship, including about two dozen parishes in the diocese covering Queens and Brooklyn, where Catholic officials have sued Mr. Cuomo in federal court, insisting that they have been abiding by the rules and should not be punished.

Weve gone above and beyond what they have recommended and mandated, said Dennis Poust, a spokesman for the New York State Catholic Conference. So if theres an animus, its coming from his end, not our end.

Leaders of the Diocese of Brooklyn and the Archdiocese of New York have also criticized the restrictions, which have closed nonessential businesses and limited occupancy in so-called red zones to 25 percent of building capacity or a mere 10 people, whichever is lower.

To have all of the steps weve taken be ignored, and to face the prospect of indefinite unreasonable restrictions placed upon our churches is just not fair! Cardinal Timothy M. Dolan wrote in a blog post last week. Why are churches being singled out? Why especially are those houses of worship that have been exemplary, strict and successful in heeding all warnings, being shut down again?

GLOBAL ROUNDUP

Polands deputy prime minister and de facto leader, Jaroslaw Kaczynski, is going into quarantine after learning that he had been in contact with someone infected with the coronavirus, a government spokesman said, adding that Mr. Kaczynski, who is 71, feels well and will continue performing his duties from home.

Mr. Kaczynski did not wear a mask when he handed out an award at a ceremony last week, and briefly took off his mask when he was sworn in as deputy prime minister on Oct. 6.

Poland largely resisted the first wave of the pandemic with an early lockdown that began in March. But after it reopened all its schools for in-person instruction in early September, case counts started climbing, and the country is now battling a major surge of infections and hospitalizations. Poland has reported 49,950 new cases in the last seven days, according to a New York Times database, and 175,766 in all, with more than 3,500 Covid-19-related deaths.

With hospital beds filling up, there is particular concern about the damage that the virus could sow in Poland, which has a relatively weak health care system and one of the lowest ratios of doctors and nurses to residents in the European Union.

To deal with the surge, the government is transforming the national stadium in Warsaw into a field hospital. The health minister, Adam Niedzielski, said on Monday that temporary Covid-19 hospitals would also be set up in other major cities, and that he was in discussions with private hospitals about making more beds available. Mr. Niedzielski warned that if the virus continued to spread at its current pace, the country could soon be facing as many as 20,000 new cases a day.

In other developments around the world:

Restrictions on nonessential travel between the United States, Canada and Mexico will be extended until Nov. 21, Chad Wolf, the acting secretary of Homeland Security, announced on Monday. We are working closely with Mexico & Canada to identify safe criteria to ease the restrictions in the future & support our border communities, Mr. Wolf wrote on Twitter. In the past seven days, Canada has reported 16,284 cases, which works out to 44 per 100,000 people; Mexico, 33,724 cases, or 27 per 100,000; and the U.S., 396,305 cases, or 119 per 100,000.

Officials in Melbourne, Australia, announced some easing of one of the worlds strictest lockdowns, allowing residents to travel up to 25 kilometers from their homes and up to 10 people from two households to socialize outdoors. Dan Andrews, the premier of the state of Victoria, drew a contrast between the situation there and in Britain, where there have been fewer restrictions despite a surge in cases. Back in August and at our peak, we reported 725 daily cases. At the same time, the U.K. recorded 891, he said in a statement. Today, as Victoria records two new cases, the U.K. hit 16,171. And as we continue easing our restrictions, they are being forced to increase theirs.

Twenty-five crew members aboard a livestock carrier docked at a port in Western Australia have tested positive for the coronavirus. The ship, the Al Messilah, has 52 crew members, and the authorities warned that further positive test results were possible.

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Live Covid-19 Updates: The Latest Globally - The New York Times

For Trump, Covid-19 therapeutics are the new vaccines – STAT – STAT

WASHINGTON In North Carolina last week, President Trump told voters at a campaign rally not to fear Covid-19 because theyd soon have access to a coronavirus cure. The experimental treatment, he told supporters the next day in Iowa, made him feel like Superman. In Florida, he told seniors theyd soon have access, for free, to the antibody therapy hed received during his own bout with the virus two weeks before.

Its a significant shift. Trump campaigned for months on the dubious pledge that a vaccine would be available before a very special date, an open nod to Election Day. But as its become clear drug companies wont help Trump deliver on a key campaign promise by Nov. 3, hes largely dropped the aggressive vaccine rhetoric. Instead, hes begun to campaign on equally lofty boasts of a Covid-19 cure-all even though the treatments remain unproven and unavailable to the general public.

We have to get em approved, and I want to get em to the hospitals where people are feeling badly, Trump said in a recent video. Thats much more important to me than the vaccine.

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Trumps pivot to touting therapeutics underscores his desperation to claim that his government is making significant progress in combating the pandemic. And it is an attempt, too, to turn his own Covid-19 diagnosis from a weakness into a strength, bolstering the dangerous arguments that Americans shouldnt fear the virus or let it dominate their lives.

Clearly, theres been a shift in what the President talks about, said Walid Gellad, a physician and health policy professor at the University of Pittsburgh. That may just be a factor of the personal experience, although clearly its also related to the reality of the vaccine. I dont know which of those it is.

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Trumps latest comments have stoked additional fear among public health experts and scientists that Americans will take the presidents advice and largely ignore the pandemic unfolding around them. Even as Trump campaigns regularly in front of thousands of mostly unmasked supporters, case rates are spiking across the country. Over 700 Americans still die of Covid-19 each day.

Even amid the spikes, Trump has argued that Americans should return to business as usual, given the existence of the experimental therapies.

Public health experts are still urging people to continue to follow social distancing guidelines and to wear masks in public. With the weather growing colder, Americans spending more time indoors, and the holiday travel season approaching, experts including Tony Fauci, the governments leading infectious disease researcher, warn that failure to adhere to basic public health guidelines could have deadly consequences.

Trump has fixated particular on a treatment hes referred to as Regeneron in fact, an as-yet-unnamed cocktail of antibodies being developed by Regeneron, a New York drug manufacturer. Trumps effusiveness even led the Lincoln Project, a coalition of Republicans opposed to his re-election bid, to publish a fake commercial mocking Trump for hawking an unproven cure.

Youve got to open up your businesses, open up your schools, Trump said at a campaign rally in North Carolina on Thursday. We have incredible therapeutics, we have incredible drugs, we have, in my opinion, a cure. Because I took something, Regeneron, it was highly sophisticated stuff. The antibodies, and Eli Lilly makes an incredible drug.

Its unclear whether Americans are taking his words to heart. Trumps message, however, is clearly out of step with reality, given skyrocketing case rates and a corresponding increase in Covid-19 hospitalizations.

I have not seen any polling on whether this latest fusillade of claims regarding that great drug Regeneron has convinced anyone that there are cures out there, period, let alone readily available ones for the population, said Peter Bach, a doctor and health policy researcher at Memorial Sloan-Kettering Cancer Center in New York. I cant remember how many times the boy had to cry wolf before he was ignored, but I am sure the president has exceeded that number by now, probably by severalfold.

Trumps tone regarding new Covid-19 therapies has exceeded even his prior effusiveness regarding vaccines: Since his release, Trump has attempted to convince Americans theyll soon have access to the same level of treatment he received at Walter Reed.

We have Regeneron, we have a very similar drug from Eli Lilly, and theyre coming out, and were trying to get them on an emergency basis, Trump said in a video posted to Twitter on Oct. 7, in which he said contracting coronavirus may have been a blessing from God. Weve authorized it, Ive authorized it, and if youre in the hospital and youre feeling really bad, I think were going to work it so that you get em, and youre going to get em free.

The promises ignore key context: The president is among a small handful of people around the world whove received access to the Regeneron antibody therapy outside the setting of a clinical trial. The Food and Drug Administration has not yet issued an emergency use authorization for either therapy in fact, one trial testing Eli Lillys antibody treatment for hospitalized patients was recently paused following a potential safety concern.

As with other once-touted Covid-19 treatments, however, Gellad said the presidents enthusiasm could do more harm than good, especially when it comes to the publics perception of the FDA. Trump has already telegraphed that his administration will soon issue emergency authorizations for both the Regeneron and Eli Lilly antibody therapies. If the FDA does so, it might appear that Trumps rhetoric influenced the decision even if the agencys scientists didnt factor in the presidents eagerness. The scenario has already played out twice in 2020, Gellad said: First over the malaria drug hydroxychloroquine and again over the use of blood plasma from recovered Covid-19 patients.

The perception, and the reality, is that theres a lot of political interference, whether its addressing hydroxychloroquine, plasma, antibodies, or vaccines, Gellad said. In reality, all of these drugs might fit the criteria for what FDA would have done probably anyway.

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For Trump, Covid-19 therapeutics are the new vaccines - STAT - STAT

Trends in Overall and Non-COVID-19 Hospital Admissions – Kaiser Family Foundation

Approximately seven months after the coronavirus sparked social distancing measures and concerns about hospital capacity, new medical records data help shed light on the magnitude of the drop in hospital admissions and the more recent rebound in hospitalizations. These new data provide additional information to help assess the economic impact of the COVID-19 pandemic on hospitals and insurers and also provide more information to help assess the extent to which people are still delaying or forgoing care. We analyze trends in total hospital admissions and then separately analyze non-COVID-19 admissions by patient sex, age, and region. We calculate actual admissions as a share of total predicted admissions in 2020 based on trends from past years. Key findings include:

This new analysis is based on electronic medical record (EMR) data from Epic Health Research Network (EHRN) and includes all inpatient hospital admission volume from Dec 31, 2017 to August 8, 2020, involving patients who either were discharged or died, as of September 13, 2020. Data are aggregated weekly and pooled from 27 health care organizations in the United States, representing 162 hospitals that span 21 states and cover 22 million patients. These states represent 67.0% of COVID-19 cases as of September 23, 2020 and also represent 66.5% of the U.S. population. Predicted volume was calculated using historical data from Dec 31, 2017 to Jan 25, 2020. COVID-19 admissions were identified as admissions with either a documented COVID-19 diagnosis (U07.01) or other respiratory diagnosis involving a patient who either had tested positive or presumptive positive for COVID-19 or received a COVID-19 diagnosis within 14 days of the admission.

Several recent studies show that, beginning in March 2020, social distancing measures, concerns over hospital capacity, and fears of contracting COVID-19 led to sharp declines in health care spending. Across all health care services, not including pharmaceutical drugs, expenditures were down 38% in April 2020, compared to April 2019. More recently, overall spending on health care has started to rebound and, by June, spending was only 10% lower than the previous year.

An earlier EHRN analysis of EMR data found similar patterns for emergency department visits for acute myocardial infarctions and stroke, with sharp declines followed by increases that brought those emergency department visits roughly back to expected rates. In late March to early April, the incidence of these conditions as reported in hospital emergency department records was down by 45% for AMIs and 38% for strokes.By the end of May, the weekly incidence of acute myocardial infarction admissions had returned to approximately 92% of the pre-pandemic trend (prior to March 13, 2020). Similarly, the incidence of emergency department visits for stroke returned to approximately 87% of the historical trend. Analysis of EMR data for breast, cervical, and colon cancer screenings showed an even sharper decline beginning in early March followed by an increase in screenings; even so, screening rates have remained far below 2019 levels. By mid-June, weekly volumes for these cancer type screenings remained roughly 30-35% lower than their pre-COVID-19 levels.

A recent analysis of outpatient office visits published by the Commonwealth Fund found that visits fell nearly 60% by early April and then increased, plateauing as of July at 10% below the pre-pandemic baseline. Another analysis of outpatient visits that included data through May 15, 2020 found that non-COVID-19 outpatient visits dropped by almost 40 percent by mid-April and then started to increase by mid-April. An analysis of data from 18 states that was published by the Health Care Cost Institute found similar patterns for childhood vaccinations and cancer screenings. A study published in September in Health Affairs used data from a national medical group specializing in hospital medicine to analyze hospital admissions. That study reported similar patterns to ourswith all medical admissions in April having declined by 34.1%, and by June/July they were 8.3% lower relative to baseline volume.

Our analysis of EMR data shows a precipitous drop in hospital admissions starting the week of March 14, 2020, falling to a low of roughly 70% of predicted admissions by the week of April 11 (Figure 1)just four weeks after the March 13, 2020 national emergency proclamation. Admissions gradually began to increase soon after that date and, by July 11, admissions were back to approximately 95% of their predicted level. More recently, total admissions dipped slightly and are now at about 90% of predicted levels.

The lost admissions between March 8 and August 8, 2020 account for 6.9% of the total number of admissions predicted during the 2020 calendar year. If the number of admissions remains at about 90% of predicted admissions (as they were on August 8) through the end of the year, total admissions will be 10.5% below predicted volume for the entire year. If there are new restrictions on non-emergency procedures in the latter part of 2020, the share of lost admissions likely will be higher.

Implications for hospital finances

This drop in admissions was not something that hospitals could have anticipated at the beginning of the year and suggests revenue losses that may be difficult for some hospitals to weather. Hospitals financial strength differs widely. One recent study found that the median hospital had enough cash on hand to pay itsoperating expenses for 53 days in 2018, but the 25thpercentile hospital only had enough cash on hand for 8 days. Smaller hospitals and rural hospitals are among those most likely to face financial challenges in the wake of revenue loss related to COVID-19. These hospitals may be more likely to close or merge if they do not have the financial resources to make up for declines in revenue caused by the declines in admissions shown in our data.

Hospitals and other health care providers have qualified for various types of federal assistance during the coronavirus pandemic. However, much of this money was not targeted to safety net hospitals operating on narrow margins. Most notably, hospitals and other Medicare and Medicaid providers received grants from the $175 billion provider relief fund that is being distributed by the Department of Health and Human Services (HHS). Hospitals qualified for grants that were the equivalent to a minimum of 2% of revenue and on average received grants that amounted to about 5.6% of revenue. Hospitals that qualified for additional grants either qualified by seeing a high number of COVID-19 inpatients by June 10 or were childrens hospitals, rural hospitals and/or safety net hospitals. About $30 billion remains available for future grant allocations as of October 8, 2020. It is unclear how the Department of Health and Human Services will allocate that money. How declines in admissions translates into lost hospital revenue depends on the type of admissions that were missed and which insurers paid for those admissions. Private insurers typically reimburse at higher rates than Medicare or Medicaid, and reimbursement widely varies by type of admission.

Hospitals and other providers that participate in traditional Medicare were also eligible for loans through the Medicare Accelerated and Advance Payment Programs, which are designed to help hospitals facing cash flow disruptions during an emergency. About 80% of the $100 billion in loans went to hospitals. Repayment for the loans was originally set to begin in August, but Congress later delayed when repayments would begin and extended the period for repayment.

Hospitals are also receiving a 20% increase in inpatient reimbursement for COVID-19 patients during the current public health emergency. The Congressional Budget Office estimated that this change will increase Medicare spending by about $3 billion. Hospitals may also be eligible for loans being distributed by the Treasury department, the Federal Reserve, and Small Business Administration.

Implications for insurer finances

Health insurers, in contrast, may be benefiting financially from this decline in hospital admissions. Many insurers have been reporting large profits despite voluntarily eliminating cost sharing for patients with COVID-19. The Affordable Care Acts (ACA) Medical Loss Ratio limits the share of premiums that insurers can keep for overhead and profit. This means that beneficiaries get a refund check from their insurer if it did not spend a sufficient share of premiums on health care costs for beneficiaries. Using preliminary data reported by insurers to state regulators and compiled by Market Farrah Associates, KFF estimated insurers will be issuing a total of about $2.7 billion in rebates across all markets in 2020nearly doubling the previous record high of $1.4 billion last year.

We used EMR data from EHRN to look specifically at non-COVID-19 admissions by patient sex, age and region. By looking specifically at non-COVID-19 admissions, we can more easily assess declines in the use of health care due to voluntary and mandatory delays in non-emergency care. This analysis does not include specific diagnoses or procedures to assess which types of admissions had the steepest declines. Declines in certain types of admissionssuch as car crashesmay be explained by changes in habits due to the coronavirus pandemic. However, as discussed earlier in this paper, declines in cancer screenings suggest that the overall decline in admissions is also a sign of patients delaying or foregoing preventive care and therefore not starting necessary treatments. Some cancer treatments were also delayed earlier in the pandemic, although those treatments may now have resumed in many cases.

Non-COVID-19 admissions by sex

Non-COVID-19 admissions for both male and female patients dropped to about 60% of predicted admissions in April 2020 and then increased to roughly 85-90% of predicted admissions by the summer (Figure 2). On an absolute level, admissions for female patients remained about 20% higher than for male patients (data not shown). Much of this differential is likely due to womens admissions for childbirth.

Non-COVID-19 admissions by age

We stratified the EHRN admissions data by age to assess trends in non-COVID-19 admissions for patients age 65 and older compared to younger patients. We found that admissions for patients age 65 and older was just 50-55% of predicted levels in April 2020, compared to 65-70% of predicted levels for younger patients (Figure 3). Admissions among patients age 65 and older have not rebounded as quickly as younger patients. Admissions for patients age 65 and older were at roughly 80% of their predicted level in late July and early August, while admissions for patients under age 65 were at approximately 90% of predicted levels during the same time period. Individuals age 65 and older may be more reluctant to schedule non-emergency procedures given that they are at higher risk of serious illness if infected with the coronavirus.

The slower return to normal among older patients may lead to a change in hospitals payer mix. While patients age 65 and older typically have Medicare, the majority of younger patients have private insurance, which typically reimburses at a higher rate than Medicare. If hospitals experience an increase in the share of patients with private insurance, that could help mitigate some of the revenue declines they are likely to see from a drop in overall admissions.

Non-COVID-19 admissions by region

We next examined how non-COVID-19 admission trends differed across geographic regions, using the regions defined by the U.S. Census Bureau. To give a sense of the geographic distribution of our dataset, admissions from the Northeast, Midwest, South, and West regions account for 22%, 37%, 28%, and 13% of overall admissions, respectively. Hospitals in the Northeast experienced the steepest decline in non-COVID-19 admissions, with those admissions decreasing to a low of roughly 50% of predicted admissions the week of April 11 (Figure 4). Admissions in the Northeast have since increased and were at 87% of predicted levels in early August. Hospitals in the Midwest followed a similar pattern but did not experience quite as steep an initial decline in admissions. In the South, where the number of cases increased in some states during the summer, there has been less of a rebound in non-COVID-19 admissions and those admissions were about 82% of predicted levels in early August. Hospitals in the West did not experience as large a decline in admissions, but also have not experienced as large of a rebound. By early August, admissions in the West were at about 83% of predicted levels.

This new analysis from the Epic Health Research Network provides additional insights into patterns of hospital admissions during the COVID-19 pandemic. This adds to a body of research showing the steep decline in admissions in the spring followed by a more recent rebound in admissions. By looking at the patterns in non-COVID-19 admissions, we can see how changes in behavior had a differential impact by region, age, and sex. If overall hospital admissions remain at or above 90% of predicted admissions, hospital revenues may stabilize at a somewhat sustainable level. However, if the coronavirus begins to spread more rapidly later in the fall and non-emergency procedures are once again delayed, it could have serious consequences both for hospitals financial stability and the health of patients.

Tyler Heist, Ph.D., and Sam Butler, M.D., are with the Epic Health Research Network. Karyn Schwartz, M.P.H., is with KFF.

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Trends in Overall and Non-COVID-19 Hospital Admissions - Kaiser Family Foundation

Covid-19 testing lags as cases increase across the United States – NBC News

While critics of wide scale testing, including President Donald Trump have asserted that surges in cases can be explained by increased testing, health experts say that a jump in confirmed cases is usually caused by more people getting sick.

And those experts, who have long urged that testing is a critical tool in the fight against the pandemic, say that the lack of aggressive and consistent testing has contributed to the viruss spread.

If we really wanted to get things under control, frequent testing of almost everybody would be one way to do it and were, of course, nowhere near that, Marc Lipsitch, a professor of epidemiology at the Harvard T.H. Chan School of Public Health, said. Were doing infrequent testing of almost no one.

There are several reasons why states arent conducting enough tests, experts say, including the diminished fear of the virus on the part of some people, who are increasingly getting tired of wearing masks, practicing social distancing and seeking Covid-19 tests.

The initial level of fear is not at the level that it was, said Melissa Nolan, an assistant professor of epidemiology at the University of South Carolina, which has resorted to offering students T-shirts and raffles as an incentive for testing. Testing fatigue and mask-wearing fatigue is real.

Without widespread testing, cities and states dont have the ability to track who has the virus and who is at risk of getting it, experts say.

There's still a dearth of testing, Lipsitch said, pointing to colleges and sports as areas that are able to operate through the pandemic due to aggressive testing policies. In places with higher resources, such as universities, you can actually figure out where people are getting exposed and infected.

Nigel Chiwaya is a deputy data editor for NBC News.

Joe Murphy is a data editor at NBC News Digital.

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Covid-19 testing lags as cases increase across the United States - NBC News

A Doctor Weighs In As Families Discuss Thanksgiving Plans And COVID-19 Risk – Here And Now

Many families are starting to have tough conversations about whether or not to gather together for Thanksgiving amid the coronavirus pandemic.

Thanksgiving weekend is usually one of the busiest travel holidays in the U.S. But this year, Dr. Anthony Fauci is urging families to scale back their holiday plans.

It is unfortunate because thats such a sacred part of American tradition the family gathering around Thanksgiving, Fauci told CBS Evening News last week. But that is a risk.

Dr. Carlos del Rio, a professor of global health and epidemiology at Emory University in Atlanta, says transmission between family members is high because we tend to be maskless and congregate in indoor common spaces.

Earlier this month, Dr. Deborah Birx warned that COVID-19 transmission is different than in the spring as people move indoors, humidity drops and respiratory droplets stay in the air longer.

Birx added that in Utah, public health officials traced 80% of coronavirus infections to small gatherings where people let down their guard, The CT Mirror reports.

Seeing family members outside of your bubble may appear safe because they are people you are familiar with, he says. But that doesnt mean you should get too comfortable, he says.

People are going to be getting together with people that they feel comfortable with when the reality is there could be transmission happening, he says.

And even if you all live under one roof, COVID-19 transmission is still possible. For example, del Rio says he and his wife live together but work at different hospitals, thus risk of infection persists in their bubble.

For travel, flying may be pretty safe, he says, because of the cleaning measures airlines are taking. Many airlines are filtering the air and making masks mandatory, he says.

What may be a little more challenging is the pre-boarding process, he says, such as taking a taxi or ride-share to the airport, security lines and just being in the airport.

If you plan to gather for the holidays, he says to keep it to less than 10 people and try to make sure everyone is healthy. Its okay to share food, he says, but keep social distancing in effect while eating. Avoid hugging and being in close proximity, he advises.

And if you can, get a coronavirus test beforehand, he says.

If you can get people tested, I think that's useful, he says. But again, remember, a test helps you identify who's infected, not necessarily who's not.

The Centers for Disease Control and Prevention recently released guidance on holiday gatherings and what Americans need to do to stay safe while traveling, hosting or attending a Thanksgiving get-together.

Del Rio says the CDCs precautions, such as correctly wearing a face mask and social distancing, during travel and gathering can be taken to lessen the risk.

Ashley Lockeproduced and edited this interview for broadcast withTodd Mundt.Serena McMahonadapted it for the web.

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A Doctor Weighs In As Families Discuss Thanksgiving Plans And COVID-19 Risk - Here And Now

Oct. 19: Iowa reports 508 new COVID-19 cases, 275 recoveries and 6 deaths – KTIV

(KTIV) -- There were 508 new, confirmed cases in Iowa from 10 a.m. Sunday to 10 a.m. Monday,according to the state's dashboard.

At 10 a.m. Saturday, health officials reported 107,062 total positive cases across the state, that number rose to 107,570 by 10 a.m. Monday.

The state's website says out of those who have tested positive, 82,056 have recovered. That's an increase of 275 recoveries in the last 24 hours.

The state reported six additional deaths within this time frame, putting the state's death toll to 1,534.

According to the state's latest report, there are 480 Iowans hospitalized due to the virus. Of those hospitalizations, 113 are in the ICU and 45 are on ventilators.

In Iowa, 2,876 new tests were given for a total of901,746 people that have been tested for COVID-19.

As of 9 a.m. Monday, the Siouxland District Health Department reported 49 new COVID-19 cases in Woodbury County. This brings the county's total number of positive cases up to 6,748.

The SDHD has reported no new virus-related deaths, keeping the county's death toll to 89.

To date, 5,022 of the county's cases have recovered.

A total of 64 people are currently hospitalized with COVID-19 in Woodbury County. Forty of those are county residents.

Buena Vista County, where Storm Lake is located, has had one new COVID-19 case, bringing its total cases to 2,195. Of those cases, 1,939 of them have recovered.

So far, the county has had 12 total COVID-19 deaths.

Clay County, where Spencer is located, has reported three new virus cases, with its total now at 482. Of those cases, 294 have recovered

Clay County has confirmed four total virus-related deaths.

State health officials say Dickinson County reported two new cases, bringing their total positive cases to 684. Officials say 479 of those cases have recovered.

Dickinson County has had seven virus-related deaths.

Plymouth County's total positive cases have risen from 1,531 to 1,535 in the last 24 hours. Officials say 1,046 of those cases have recovered.

Plymouth County has reported one additional virus-related death, bringing its death toll up to 25.

As of Oct. 19, the state health department says Sioux County reported four new cases bringing their total to 2,286. Officials say 1,392 of those cases have recovered.

Sioux County has had no additional virus-related deaths, keeping its death toll to 11.

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Oct. 19: Iowa reports 508 new COVID-19 cases, 275 recoveries and 6 deaths - KTIV

First@4: Active COVID-19 case record in S.D.; Region in a tense spot; Shooting investigation – KELOLAND.com

SIOUX FALLS, S.D. (KELO) Heres a look at the top stories as of 4 p.m.

Active COVID-19 cases set another record in South Dakota on Monday, based on data from the state Department of Health.

On Monday, 567 new coronavirus cases were announced, bringing the states total case count to 33,836. Total recovered cases are now at 25,125. But active cases, which passed 8,000 for the first time on Sunday, are up to 8,388.

Only eight counties are listed as having moderate community spread; the other 58 counties in South Dakota are listed as having substantial community spread.

Sioux Falls Mayor Paul TenHaken says people in the region need to do more to slow the spread of coronavirus.

We are in a tense spot and we need you to do more, TenHaken said.

He stressed the importance of social distancing and hand hygenine as COVID-19 cases surge in the state.

Wear a dang mask, TenHaken said while referencing a letter sent from mayors of several South Dakota towns with a request to residents.

Sioux Falls Police said a suspect accused of firing a gun at officers died of a gunshot to the head, but the origin of that shot isnt known yet.

The South Dakota Department of Criminal Investigation is looking into the incident.

Two Sioux Falls Police Officers responded to a call about a person who would not leave an apartment. They found the suspect in a hallway just before the suspect fired at one of the officers.

Both officers are on administrative leave.

Snow has fallen across KELOLAND on Monday. Get the latest forecast from the KELOLAND Live Doppler HD StormCenter in the video player below.

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First@4: Active COVID-19 case record in S.D.; Region in a tense spot; Shooting investigation - KELOLAND.com