LANL: Jaqueline L. Kiplinger To Receive Award For Pioneering Contributions To Chemistry – Los Alamos Daily Post

Jaqueline Kiplinger is the recipient of the 2017 Violet Diller Professional Excellence Award. Courtesy/LANL

LANL News:

Jaqueline Kiplinger, Los Alamos National Laboratory Fellow within the Inorganic, Isotope and Actinide Chemistry Group, is the recipient of the 2017 Violet Diller Professional Excellence Award given triennially by Iota Sigma Pi (the National Honor Society of Women in Chemistry). The award recognizes contributions to chemistry that have had widespread significance to the scientific community or society on a national level.

The Violet Diller Professional Excellence Award recognizes Kiplingers outstanding achievements in science, service to the broad chemistry community and mentoring of early career researchers, said Alan Bishop, Principal Associate Director of Science, Technology and Engineering at Los Alamos.

As a pioneer in uranium and thorium chemistry, her research has significantly expanded the understanding of actinide and lanthanide chemical bonding and reactivity. Her workprovides scientific underpinning that supports the Laboratorys national security mission, advances the fundamental understanding of actinide chemistry and promotes the development of postdoctoral fellows at a critical time in their careers, he said.

Kiplinger will present a summary of her work and receive her award during a ceremony at the July 2017 Iota Sigma Pi national convention. Iota Sigma Pi was founded in 1902 and serves to promote the advancement of women in chemistry by granting recognition to women who have demonstrated superior scholastic achievement and high professional competence by election into Iota Sigma Pi.

Kiplinger is an internationally recognized leader in f-element chemistry, the study of lanthanides and actinides. Kiplinger came to Los Alamos as the first Frederick Reines Postdoctoral Fellow in 1999. She is a Fellow of the American Association for the Advancement of Science, the Royal Society of Chemistry and the American Institute of Chemists. The breadth and depth of her accomplishments are reflected by her peer-reviewed publications, granted patents, invitations to contribute to prestigious monographs and review articles, and plenary lectures delivered at international conferences in the field.

Her scientific achievements have been recognized by a Los Alamos Fellows Prize for Research, two R&D 100 Awards, three mentoring awards, and several Los Alamos/NNSA Best-in-Class Pollution Prevention Awards. In 2015, Kiplinger was selected as the first woman to receive the F. Albert Cotton Award in Synthetic Inorganic Chemistry from the American Chemical Society.She is also the first scientist at the Laboratory to have been honored with two national-level ACS awards, the first being the 1998 Nobel Laureate Signature Award in Chemistry. Earlier this year, she was also the recipient of the 2017 International Union of Pure and Applied Chemistry (IUPAC) Distinguished Women in Chemistry award.

About Los Alamos National Laboratory (www.lanl.gov)

Los Alamos National Laboratory, a multidisciplinary research institution engaged in strategic science on behalf of national security, is operated by Los Alamos National Security, LLC, a team composed of Bechtel National, the University of California, BWX Technologies, Inc. and URS Corporation for the Department of Energys National Nuclear Security Administration.

Los Alamos enhances national security by ensuring the safety and reliability of the U.S. nuclear stockpile, developing technologies to reduce threats from weapons of mass destruction, and solving problems related to energy, environment, infrastructure, health and global security concerns.

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LANL: Jaqueline L. Kiplinger To Receive Award For Pioneering Contributions To Chemistry - Los Alamos Daily Post

Syrris Asia flow chemistry, designed for you – Technology Networks

Flow chemistry presents an opportunity for you to enhance your chemistry. The main advantages compared to traditional batch techniques include increased safety, speed, and selectivity, the ability to discover new chemistry (or access previously restricted chemistry) and offering easy access to scale-up.

Syrris is the longest established provider of laboratory scale flow chemistry systems, Syrris wealth of expertise in research and development has propelled the modular Asia product line to the forefront of the flow chemistry market.

Asia is a revolutionary range of advanced flow chemistry products from Syrris. It has been designed by chemists for chemists to enable the widest variety of chemical reactions and ultimate ease of use.

Asia offers a variety of flow chemistry modules and systems in either entry level or advanced configurations for both beginners with modest budgets and experts who demand the utmost functionality. The unique benefits of flow chemistry make it a suitable tool for a wide range of applications.

Well prove your chemistry can be performed better in flow. Contact our in-house experts today if you have an application in mind and we can advise you on how to enhance your chemistry.

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Roommates Bud Cauley and Justin Thomas hope their chemistry … – GolfDigest.com

The prized possession in the house they share in Jupiter, Fla., is a pool table specially designed with crimson-colored felt and the fabled Bama logo. So if youre looking for chemistry and energy between partners in this weeks Zurich Classic, then look no further than the Roll Tide team of Bud Cauley and Justin Thomas.

The pool table in the house Justin Thomas shares with Bud Cauley.

Their insane love of Alabama has them traveling to Tuscaloosa for football games when theyre not shooting pool or practicing at The Bears Club and Medalist G.C. during breaks at home.

Were racked up a couple games on that [table], Thomas was telling me before leaving for New Orleans. If this was a golf/pool contest, Id like our chances even more.

They are one of two teams from the University of Alabama golf program competing in this weeks team championship at the TPC Louisiana. Trey Mullinax and Bobby Wyatt will also be representing the Crimson Tide.

SAN ANTONIO, TX - APRIL 21: Bud Cauley plays his shot on the 18th hole during the second round of the Valero Texas Open at TPC San Antonio AT&T Oaks Course on April 21, 2017 in San Antonio, Texas. (Photo by Steve Dykes/Getty Images)

Steve Dykes

Cauley was a junior when Thomas made one of his visits to Alabama but they never connected until after school. Cauley turned pro his senior year and never had a chance to team up with Thomas in a college event. Their compatibility developed while Cauley identified himself among a peer group now in their late 20s that included Rickie Fowler, Peter Uihlein and Patrick Reed. You could put us in any sort of situation, Thomas says, and wed have fun.

Only five players prior to Cauley earned their PGA Tour cards without going to Q School, and its an illustrious list comprised of Gary Hallberg, Phil Mickelson, Justin Leonard, Tiger Woods and Ryan Moore, with Jon Rahm joining the group last year. Only Woods and Mickelson qualified with less starts than the 10 it took Cauley to earn full-time playing privileges for the 2011 season. This was lost on Ernie Els when they were paired together in the Frys.com Open that year, when Els asked Cauley when he was going to turn pro. Cauley shot 66 in the final round to finish T-3 and earn $340,000.

I always looked up to him a little bit, says Thomas, who is five years younger. He was the first person I reached out to once I got on tour [in 2014]. We started playing together, hanging out more. Hes kind of become one of my best friends.

Thomas enrolled at Alabama in fall 2011 and won the Fred Haskins Award as the nations top collegiate golfer the next spring. He was on a National Championship team in 2013 and turned pro later that fall.

Cauleys early success on tour was slowed by injury in 2014 when he tore the labrum in his left shoulder. He needed surgery which forced him to spend 15 months of inactivity on his couch, binge-watching movies and TV shows on Netflix.

That drove me absolutely insane, Cauley says of those days. It was frustrating professionally and not the way I saw my career going at all.

As Alabama coach Jay Seawell pointed out, Cauley was the type of player he needed to make take a day off. It does deflate you, Seawell says of Cauleys mandatory downtime. But it matures you at the same time. As much as it hurt, I think he learned to appreciate the game even more.

Swing instructor Matt Killen has the same takeaway after caddieing for Cauley at TPC San Antonio. He hasnt lost any speed. None of injuries cost him long term, says Killen, who also works with Thomas. Once he settles into golf, and gets back in the mode, hell be able to score.

A T-3 at the CareerBuilder Challenge in January was the career builder Cauley needed for his confidence. Some of that scoring ability Killen referred to came through three months later in back-to-back top-10s at the RBC Heritage (where he opened with a 63) and the Valero Texas Open (where he was tied for the lead with Tony Finau after opening rounds of 70-66).

One thing for certain, hes got a strong partner. Now 23, Thomas has established himself among the players of his generation with three victories in the 2016-17 wrap-around season. That doesnt account for the wins theyve recorded among the matches played by tour pros living in the Jupiter area. Unless its a Wolf game, Cauley and Thomas are always partners.

I know hes excited where his game is at, and I am, too, Thomas. Because hes my partner this week.

In other words, rack em up.

WATCH: GOLF DIGEST VIDEOS

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This interactive periodic table makes chemistry easier than ever – TNW

Chemistryhas broken the spirits of many struggling high-schoolers and university students alike, but there might be a handy tool that can finally guide you through the various elements and help you swiftly get thehang of the much-dreaded periodic table.

Available for free,PeriodicStats is an elegantly designed web-based interactive periodic table thattakes the hassle out of chemistry by putting together the basic properties of all elements in a clean and well-structured manner.

Gary Vaynerchuk was so impressed with TNW Conference 2016 he paused mid-talk to applaud us.

For more detailed information about the properties of individual elements, you can click on the element of your interest and PeriodicStats will readily pull up crucial information likeyear of discovery, density andtype of substance.

The interactive table also offers data about the precise electron and ionisation propertiesof each element as well as numerousbits and pieces abouttheir history.

In addition to the extensive catalogue of elements, PeriodicStats also features a nifty search engine that lets you filter out certain elements based on various criteria like bonding, magnetism, melting and boiling point, density and so on.

Now go step up your chemistry game and browse through PeriodicStats here.

In case youre seeking for more practical-oriented knowledgeof the periodic table, you might want to check out this alternative interactive periodic table that aims to clue people in as to what the various elements can be used for in the real world.

Periodic Stats Interactive Periodic table

Read next: Young and talented? Theres one week left to apply for the T500!

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Eugenio Derbez talks chemistry with Salma Hayek in ‘How to be a … – Newsday

Mexican comedy star Eugenio Derbez, who stars alongside Salma Hayek in How to Be a Latin Lover (opening April 28) says his on-set chemistry with the movies director, West Islip native Ken Marino, couldnt have been more perfect.

Marino, who is also an actor (Were the Millers, Role Models), did not appear in the film about Maximo (Derbez), a middle-aged gold digger who gets dumped by his rich, 80-year-old wife and is forced to move in with his estranged sister (Salma Hayek) while he pursues another wealthy widow (Raquel Welch).

He did, however, do a hell of a job directing it, said Derbez.

Hes an actor, producer, director and writer, like me, so it was really easy to work with him, and he had such a great attitude, making jokes all the time, said Derbez, whose 2013 film Instructions Not Included became the highest-grossing Spanish-language movie of all time.

Hes also very talented. I mean he shot a three-hour movie and had to cut an hour because he got such great, amazing material. We could probably have made another movie with the extra footage.

Rob Lowe, Kristen Bell, Rob Riggle and Michael Cera also are in the movie.

Derbez, 55, credits most of the films bloopers and laugh-out-loud moments to his rapport with personal friend Hayek, who he says he has known for more than 30 years even though theyve never worked together previously.

Were both Virgos. We were born on the same day actually, on Sept. 2, but in different years, he said. She always insists on being clear about that, he laughs.

Even so, for Derbez and Hayek, How to Be a Latin Lover marked their first time sharing the screen. And they just didnt expect to have so much chemistry.

Derbez says shooting alongside Hayek felt so natural, but he especially remembers one scene in which they were hanging out in a living room getting drunk on shots of tequila.

Well, the tequila was not real but it looks as if it were because we just had so much fun shooting it and couldnt stop laughing.

Hayek and Derbez are already planning to work together on future projects and dont discount the possibility of a How to Be a Latin Lover Part 2.

Listen, anyone can be a Latin lover, assures Derbez. Its just a matter of attitude, of really being confident about yourself. You have to walk into a room feeling like youre Brad Pitt, make strong eye contact and remember the power of a really good pickup line.

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Eugenio Derbez talks chemistry with Salma Hayek in 'How to be a ... - Newsday

Portland Trail Blazers’ team chemistry in early 90s was just different – Yahoo Sports

Rip City has so many fond memories and moments that come to mind when looking back at the 1989-92 Trail Blazers seasons.

The early 90s teams were special on the court, no doubt, but their bond off the court may have been even more special.

"Those were fun times,"Terry Porter reminisced on NBA TV's Trail Blazers documentary, Rip City Revival.'"There's nothing like playing professional sports. You build a bond, a brotherhood, a willingness to protect each other, and you always have that."

The final two segments of Sunday's special on the 1989-92 Trail Blazers era focused on what made this Blazers squad so unique: their team chemistry.

As you know the longer you're with a group of guys, the more chemistry you develop, especially when you're all really good friends and so that was the key to our success. -- Clyde Drexler on Rip City Revival'

[RELATED]: 'Rip City Revival' was a Trail Blazer history lesson that left out a few chapters

During Portland's 198990 campaign, the team posted a 5923 record. They defeated the Dallas Mavericks, San Antonio Spurs, and Phoenix Suns in the Western Conference playoffs, before ultimately losing to the defending-champion Detroit Pistons.

In the 199091 season, the Blazers posted a 6319 record, which was the best in the league and the best in franchise history. Theirseason ended in the West Finals when the Lakers defeated the Blazers 42.

As for the 199192 season, Portland repeated as Pacific Division champions as they dominated through the Western Conference playoffs. They met the Chicago Bulls in the Finals, losing 42, with the big storyline beingMichael Jordan vs. Drexler.

[RELATED]:'Rip City Revival' vs. 'The Last Dance': A different take on the 1992 NBA Finals

"The whole team, I mean that's what made this team so unique, is the chemistry, the personnel," Buck Williams said during the NBA TV special.

Drexler discussed how on the road they would hang out and go to movies together as a team. Porter reiterated that, adding this was a team that enjoyed hanging out with each other and would do so every chance they got.

"What made it all go was trust, we trusted each other," Williams added.

They had fun together.

"To have the success we had as a group and the excitement we brought this city and this state -- it is always going to be somewhere special in my heart. We grew up together on and off the court," Porter said.

As Drexler put it, "That bond will keep you together for a lifetime."

Be sure to check out the fullTalkin' Blazers Podcastwith host NBA Champion Channing Frye and Emmy Award winner Dan Sheldon, and Timbers midfielder Diego Valeri.

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Good chemistry of Shovels & Rope keeps getting better – Charleston Post Courier

Its often said that Michael Trent and Cary Ann Hearst essentially stumbled into discovering the musical chemistry they share as the duo Shovels & Rope.

In fact, for more than a decade, Trent and Hearst (who married in 2009) had pursued separate careers. Hearst released her first solo CD, Dust and Bones, in 2006 and followed that with a 2010 EP, Are You

Ready To Die, and a second full-length, Lions And Lambs, in 2011.

Trent, meanwhile, spent years in a band, the Films, until that group split in 2009 and also made a pair of solo albums along the way a self-titled effort in 2007 and The Winner in 2010.

While trying to decide their next moves musically, they started playing shows together around their home town of Charleston and found they liked their scrappy sound as a duo and that they could earn enough money from the shows to make ends meet.

But one thing that wasnt casual about Shovels & Rope was the couples decision to get serious about making music and turning their group into a career.

We took a good, hard look at it before we decided to do this thing in the beginning, said Trent, who joined Hearst for a recent phone interview. And both of us were like Well, if this gets to be too much, then its OK to quit and go do something else. Were like, Really, were going to be a married couple band? That sounds insane,

and it never works. But I think just establishing that before we got into all this

We were real honest about ourselves, said Hearst, who has a way of completing her husbands thoughts ways that are humorous and insightful, as well as succinct.

I think that worked to our advantage, Trent agreed.

We realized it wasnt a good idea, and then we did it anyway, Hearst said. We were just hoping it works out in the long run.

So far, so good. The couple has released Little Seeds, their third album of original material as Shovels & Rope, and their creative chemistry seems as strong as ever. And not only are they still happily married, in September 2015 they welcomed their first child, Louisiana Jean, into their family.

Trent and Hearst waited until after Louisiana Jean was born to record Little Seeds. Like their previous albums, 2012s O Be Joyful and 2014s Swimmin Time (as well as the 2015 covers album, Broken Jukebox Vol. 1), Little Seeds was made at the couples home studio.

And they quickly found that parenting threw some new twists into making the album.

Babies dont pay attention to schedules, Hearst said. Newborns dont care that you have a session scheduled at 10 in the morning.

But Little Seeds got finished and its another stirring effort. It retains the rowdy and twangy rock sound of O Be Joyful and Swimmin Time, but shows some growth both musically and lyrically.

I think every time we approach a new record, we want to expand the sonic landscape. We just want to try and do some new things, Trent said. So I think were stretching out a little bit more on this record and weve got a little bit more hair on it.

That growth is most apparent on the impressive opening track, I Know, which is arguably the most plugged-in, hard rocking song the duo has recorded, and Buffalo Nickel, a stomping, bluesy track. But Little Seeds is plenty diverse, with songs that range from the spare

balladry of St. Annes Parade and This Ride to the rollicking country rock of Botched Execution to the measured thump of Johnny Come Outside.

Lyrically, Little Seeds moves away somewhat from the story song style featured on the first two albums, adding a more personal and topical dimension to the album.

The social commentary is most evident in BWYR, a nearly a cappella call for unity whose haunting tone reinforces the gravity of the subject matter (Black lives, white lives, yellow lives, red/Lets all come together and share the bread).

Meanwhile, the poignant songs Mourning Song and Invisible Man were inspired by Trents father,

who is battling Alzheimers disease.

Trent and Hearst said they plan to play a good number of the new songs on tour this spring, but fans can expect the tunes to take on different dimensions live. Thats because Trent and Hearst tour as a twosome switching off playing guitars, drums, harmonicas and other instruments, and some songs need re-arranging to work with the limitations of having only two musicians on stage.

Trent said they like what the two-person format does for the songs.

I feel like it keeps it fresh for us, and more fun, he said. We have more instruments to pick from now that get thrown into the mix. But you can do a lot with very little to make really interesting arrangements. I think we dig that.

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Good chemistry of Shovels & Rope keeps getting better - Charleston Post Courier

Student to represent Grundy County at state chemistry competition – Morris Daily Herald

MINOOKA An eighth-grader has won a countywide chemistry competition and will move on to compete at the state level.

Cole Kics from Minooka Junior High School bested a field of 10 fifth- to eighth-grade students to become the Grundy County You Be The Chemist Challenge champion.

Local students came together in Oglesby to compete for the top prize. Cole Kics will represent Grundy County at the state-level competition.

Developed by the Chemical Educational Foundation, the challenge is a question-and-answer competition that motivates fifth- to eighth-grade students to sharpen their knowledge of chemistry concepts and their real-world applications.

Students compete for prizes at the local and state levels and the ultimate prize of a trip to Washington, D.C., to vie for college scholarships.

The challenge program relies on partnerships between community members, including industry, schools, universities and community organizations, that seek to foster student engagement with science.

The 2017 Grundy County Challenge took place at Illinois Valley Community College and was sponsored by Aux Sable Liquid Products, Flint Hills Resources, LyondellBasell. After correctly answering dozens of chemistry and general science questions during multiple rounds of competition, Kics was declared the Grundy County champion.

He will advance to the Illinois State Challenge in Romeoville on April 29.

The following top-placing students also have earned a chance to compete at the state level: Chris Karceski, Minooka Junior High School and Alex Gernenz-Coal City Middle School. Anthony Corrado-Mazon-Verona, Kinsman Middle School, will serve as an alternate at the state competition.

The winner of the state competition will receive an expenses-paid trip to Washington, D.C., to compete in the National Challenge on June 19. At the national level, state winners from across the country will vie for the title of Challenge Champion and a total of $18,500 in college scholarships.

For information about the You Be The Chemist Challenge competition, please visit CEFs website at http://www.chemed.org.

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Student to represent Grundy County at state chemistry competition - Morris Daily Herald

Ellison, other AGs pushing for crackdown on chemical used to sterilize medical devices – Minneapolis Star Tribune

Half of all medical devices used in the United States from bandages to implantable computers are sterilized with a toxic gas that has come under scrutiny over concerns about air pollution that could cause cancer.

Now, Minnesota Attorney General Keith Ellison has joined a coalition of 11 attorneys general asking the federal Environmental Protection Agency to crack down on emissions of the chemical, ethylene oxide (abbreviated as EO or EtO), which is used on an industrial scale to kill pathogens on medical devices, food spices and other products.

"Fortunately, Minnesota doesn't rank high on EtO emissions, but science is pointing to it being a far more potent carcinogen than previously thought, which puts people at greater risk than previously thought," Ellison said in an e-mailed statement. "The fact that the control equipment that federal regulations currently mandate isn't containing EtO emissions to safe levels is hurting not only local communities, but also Minnesota's medical-device industry."

Med-tech trade groups have warned in stark terms that creating additional controls on EtO or abruptly cutting back on its use could trigger widespread shortages of lifesaving medical devices.

"If someone needs a pacemaker, and they can't get one, that creates its own public health crisis," said Shaye Mandle, CEO of the Medical Alley Association trade group in Golden Valley. "We are not saying, don't do anything on EtO. We are saying, if you eliminate it tomorrow in the absence of an alternative and today there is no alternative then medical devices that use this sterilization methodology wouldn't be able to go to market."

Other sterilization methods like heat and radiation can damage the soft plastics and electronics in medical devices. The EtO industry said the gas is uniquely useful because it's highly effective at killing pathogens and can penetrate special packaging to sterilize the insides of devices and surgical kits. The gas enables manufacturers to meet the international "sterility assurance" benchmark of having less than a 1-in-a-million chance of harboring a viable pathogen.

The Food and Drug Administration is already working with companies to accelerate development and review of 11 new sterilization ideas for the medical device industry, but the federal EPA regulates EtO emissions. The EPA is now analyzing whether to lower EtO emission limits and tighten rules on how the chemical is handled.

EtO represents a conundrum for industry. It's widely believed to be a potent carcinogen for workers who handle it and people who live downwind of EtO plants, yet it's used to sterilize more than 20 billion health care products a year, preventing the spread of infectious germs.

"For many devices EO is the only method that has been shown to provide effective sterilization without causing damage to the device," Medtronic environmental health and safety director Peter J. Jansen said in a Feb. 10 comment letter to the EPA. Medtronic, the world's largest medical device company, has its operational headquarters in Minnesota.

Medtronic was one of nine companies surveyed by the EPA last year about its use of EtO, along with Medline Industries, Becton Dickinson (BD) and Sotera Health, an official with the EPA confirmed. While most med-tech companies use outsourced facilities for EtO sterilization, Medtronic and Boston Scientific also run their own EtO sterilizers, federal records show.

The United States has about three dozen EtO plants, including a Steris AST contract-sterilization facility in Coon Rapids. But the number of device-sterilizer plants currently using EtO nationally has been dropping quickly.

Sotera's Sterigenics plant in Willowbrook, Ill., permanently closed last year following strong community protest and state regulatory actions. Meanwhile, BD's plants in Smyrna and Covington, Ga., have come under fire from state officials and community groups for EtO emissions. Viant Medical agreed to close its EtO plant in Grand Rapids, Mich., earlier this year, while Medline's EtO plant in Waukegan, Ill., is reopening following a new state law that imposed stricter emission standards.

Minnesota AG Ellison has joined Illinois Attorney General Kwame Raoul and nine other state AGs in urging the EPA to essentially adopt Illinois' tougher statute, called the Matt Haller Act, and make it apply nationally. Among other things, the Haller Act requires EtO users in Illinois to capture 100% of EtO emissions from the rooms where it's used, reduce EtO emitted into the atmosphere to 0.2 parts per million, and conduct continuous emissions monitoring and ambient air testing.

"The control measures in [existing federal regulations on EtO] are not sufficiently protective of human health in light of new, compelling information," the attorneys' general letter says.

The compelling information is a December 2016 risk analysis commonly referred to the IRIS assessment, which concluded that EtO was highly likely to be a mutagenic human carcinogen even at low "environmental" levels of exposure, based on a 2004 study of the health of 18,000 people who worked at commercial sterilization plants.

Washington-based med-tech trade group AdvaMed says the IRIS report increased the suspected "cancer potency" of EtO 30-fold. That increase was set using evidence from a single study that documented many thousands of workers who were chronically exposed to "extraordinarily high" concentrations of EtO and yet did not get cancer. Only those exposed to "the very highest concentrations for the very longest periods of time," got cancer, AdvaMed wrote.

Pro-industry trade groups like AdvaMed say regulating EtO use based on the IRIS analysis would go too far, because people living downwind from EtO plants are already exposed to greater concentrations, like the EtO produced by human metabolism and by combustion in the environment.

"EtO is also a normal component of ambient air," AdvaMed wrote to the EPA on Feb. 18. "The 2016 IRIS assessment of EtO should NOT be used for regulatory purposes because it defies science and common sense in the context of everyday human exposures."

One commenter urged EPA to use IRIS risk estimates, noting that the medical device industry's own standards document, ISO 10993-7, says genetic factors may determine susceptibility to enhanced cancer risks from EtO. The comment letter, submitted anonymously to the EPA, said impaired function of an enzyme called GSTT1 in some people leaves them unable to "detoxify" EtO via metabolism, putting them at greater risk of developing health problems from exposure to it.

"No amount of ethylene oxide is safe for the public," the letter concluded.

Correction: Previous versions of this article misstated the number of EtO plants operating in Minnesota.

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Ellison, other AGs pushing for crackdown on chemical used to sterilize medical devices - Minneapolis Star Tribune

Jared Dudley breaks down how he developed chemistry with Lakers big men – Silver Screen and Roll

Jared Dudley knew when he signed with the Lakers that his off-court contributions might be more meaningful than his impact on the court. As a 34-year-old veteran of 13 years in the NBA, his mind and locker room presence have begun to eclipse his basketball productivity.

But Dudley remains invaluable for how he contributes to team chemistry. He has been a mentor to younger players in the past, a role he took on once again for Kyle Kuzma this season, and hes always available for spot minutes when there are injuries, foul trouble, or a coach is simply looking for a player to settle the team down.

That means Dudley had to develop real on-the-court chemistry with his teammates in Los Angeles. The Lakers got that process started during the offseason with LeBron James pick-up games, and in an interview with Michael Pina of SB Nation, Dudley revealed there was one specific detail he needed to work through with the teams frontcourt players.

When I got here Id turn the ball over throwing to our centers because they expected a lob, Dudley said. I dont really throw lobs, Im more of a bounce passer.

Dudley solved his problem by initiating conversations with LAs big men, verbalizing his own in-game habits so that everyone could get on the same page.

Anecdotally, I can never remember Dudley throwing a lob pass Chris Paul, he is not so Dudleys self-assessment of his distribution tracks. Per NBA Stats, he only made 16 passes to Lakers centers this season, three of which resulted in assists. That is an incredibly small sample size to work with, but if youll indulge me, lets check the tape to see how Dudley got on the same page with JaVale McGee and Dwight Howard.

Here Dudley is getting McGee two dunks.

And then a hook shot for Howard.

It appears Dudley and his bigs achieved a compromise over the course of the season. There are no lobs or bounce passes in these clips, because they met somewhere in the middle: a good old-fashioned chest pass.

Dudley is still a bounce-pass enthusiast when it comes to the Lakers backcourt, but he wouldnt be a good teammate if he didnt adjust to the habits of the other players on the roster. It would probably be asking too much of Dudley to start throwing lob passes at this stage of his career, especially considering Howards present-day vertical jump, but a chest pass gets the ball just high enough so that the team can avoid turnovers.

Chemistry has been difficult to achieve around the league, as Pina notes, but players like Dudley, who communicate nonstop, are essential to working through those challenges. Its part of why the Lakers are one of the most close-knit teams in the league.

For more Lakers talk, subscribe to the Silver Screen and Roll podcast feed on iTunes, Spotify, Stitcher, and Google Podcasts. You can follow this author on Twitter at @sabreenajm.

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DOD watchdog will review military use of cancer-linked chemical | TheHill – The Hill

The Pentagons internal watchdog will review the militarys response to a cancer-linked chemical spread in part by its use of firefighting foam.

A class of chemicals abbreviated as PFAS has contaminated water in at least 425 military sites, pushing Department of Defense (DOD) Secretary Mark EsperMark EsperOvernight Defense: VA deputy secretary fired | Impeachment trial winds down with closing arguments | Pentagon watchdog to probe use of cancer-linked chemical DOD watchdog will review military use of cancer-linked chemical US Africa Command chief makes pitch for military presence amid reported plans for cuts MORE to take action on his first day in office and start a task forceto address the substance.

The review from the DODs Office of Inspector General (OIG) is a response to a request spearheaded Rep. Dan KildeeDaniel (Dan) Timothy KildeeOvernight Defense: VA deputy secretary fired | Impeachment trial winds down with closing arguments | Pentagon watchdog to probe use of cancer-linked chemical DOD watchdog will review military use of cancer-linked chemical Pelosi digs in on impeachment rules fight MORE (D-Mich.) that asks how long the DOD has known PFAS was harmful to human health, how the military will address cleaning up the substance, and howit will take care of service members and communities harmed by PFAS.

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Simply, it appears the scope of the problem far outweighs the allocated resources and focus of the DOD, lawmakers wrote in their July request.

Lawmakers have undertaken numerous efforts to push the military to take greater steps to address PFAS, including measures in the defense policy actthat required the military to end its use of PFAS-laden firefighting foam.

OIGs decision to review the militarys response could be something of a road map for the DOD but also for lawmakers eager to make sure funds allocated for cleanup are being used effectively.

The agencys own PFAS task force, however, is also expected to release its findings shortly.

The militarys financial liability on PFAS is already expected to exceed its original $2 billion estimate.

The DOD did not respond to request for comment.

Originally posted here:
DOD watchdog will review military use of cancer-linked chemical | TheHill - The Hill

Birds of a feather: On Trump-Modi chemistry – The Hindu

When he visits India for the first time later this month, U.S. President Donald Trump can expect thronging crowds in Gujarat and perhaps a substantive discussion on trade policy in New Delhi, but more than anything, it is his growing bonhomie with Prime Minister Narendra Modi that is expected to steal the limelight. Indeed, this chemistry was evident during the four times that they met in 2019. The pinnacle of those encounters for Mr. Modi was undoubtedly the public relations victory that he won when Mr. Trump graced the Howdy Modi! event in Houston before some 50,000 Indian-Americans. Now Mr. Modi is returning the favour perhaps, as he has, in Mr. Trumps words, promised an attendance of five to seven million, from the airport to the new Sardar Vallabhbhai Patel cricket stadium, the worlds largest; here, they will address the Kem chho Trump! event before an expected 1.25 lakh people. While there will always be areas of untapped potential in bilateral cooperation, things could hardly be better between the two nations at this time of global turbulence, in trade and security. On the former issue, despite skirmishes surrounding tariffs in specific sectors, such as medical devices, and counter-tariffs following the U.S.s termination of its Generalised System of Preferences toward India last year, there is hope for at least a limited trade deal pegged at $10-billion that could take a measure of stress out of the protracted closed-door negotiations. Prospects look brighter still on defence cooperation. India is reportedly moving toward approving a $2.6-billion deal for 24 Lockheed Martin-built MH-60 Seahawk helicopters. An agreement to buy a $1.867-billion integrated air defence weapons system is also on the cards.

Notwithstanding this slew of positive, if incremental, cooperative advances, it is the deeper fault lines across the two countries domestic polities that could, in the longer-term, impact the prospects for smooth cooperation in the bilateral space. For instance, the Indian governments recent policy shifts regarding special status for Kashmir as well as the Citizenship (Amendment) Act, the National Register of Citizens and the National Population Register have spooked some U.S. Democrats, including Senators and lawmakers in the House of Representatives. Some have explicitly voiced concerns about the impact in terms of Indias commitment to remaining a tolerant, pluralist democracy. In this context, if the November 2020 presidential election puts a Democrat in the White House, it could potentially impact some of Indias plans. Even if Mr. Trump wins a second term, deepening Congressional opposition to India-friendly White House policies could endanger bilateral prospects. In this sense, there are limits to how much India can peg its strategic plans on the personal chemistry between its leader and the U.S. President.

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Birds of a feather: On Trump-Modi chemistry - The Hindu

Why diversity and inclusion at conferences matter | Opinion – Chemistry World

Most of us know how beneficial scientific conferences are; as graduate students, we often make our first professional connections outside of our own department through such meetings. New collaborations develop, cutting edge research is announced and careers are made at meetings and conferences. Having access to these opportunities is critical to career advancement in the near and long term.

Unfortunately, scientific conferences are not equally accessible or welcoming to all. Not all venues are accessible to colleagues with physical disabilities, or have facilities that are safe for transgender attendees. Current and historical practices and structures that are part of scientific meetings often result in stereotype threat, instances of microaggressions, and overall feelings of exclusion.

For example, scientists who are new parents may find it difficult to attend or participate in all aspects of a meeting. Such participants struggle with an extra cognitive load and the financial burden of arranging for childcare on site or at home to be able to attend. This extra level of effort to participate can impact the way these scientists feel included in the meeting and are able to engage.

The participation and inclusion of colleagues from diverse backgrounds is morally imperative

In another example, the 2018 report Sexual Harassment of Women by the US National Academies of Sciences found that womenworking in science are more likely to suffer harassment, with higher incidence rates among those with intersectional identities, such as women of colour or LGBTQ women. As a result they may choose not to engage where these aggressions can happen easily, such as in field work situations or at conferences.

The participation and inclusion of colleagues from diverse backgrounds is morally imperative and critical to improving the quality of scientific discovery and understanding. Conferences are an important place to take steps towards inclusion. Such actions not only improve the experiences of everyone in attendance, but also serve as a mechanism to foster inclusion in science more broadly.

The scientific community still has an embarrassingly low level of participation from women, particular ethnic and racial groups, LGBTQ colleagues, scientists with disabilities, and others from historically marginalised social identities.The 2014 Royal Society report A Picture of the UK Scientific Workforce showed that those demographics are less likely to hold senior leadership roles in science occupations than colleagues from majority populations. In the UK, only 7.9% of chemistry professors in the UK are female. Only 2.9% of UK-based scientists come from ethnic minority backgrounds. This lack of representation is evident and even exacerbated in our professional meetings and conferences.

A rich body of research shows that diversity and inclusion leads to better, more creative science

Denying historically underrepresented colleagues full access and opportunities to participate in scientific exchange, mentoring and career advancement limits not only them, but the field as a whole. Exclusive practices mean we lose access to complex types of diversity such as knowledge practices (epistemic), values (axiological) and ways of being (ontological). These stem from the lived experiences of people who are physically and culturally different from one another, and provide rich ground in which innovation can thrive. A rich body of research now shows that diversity and inclusion leads to better, more creative science.13

To realise such potential, we need to redesign our scientific institutions and activities more broadly to create opportunities for all individuals to thrive in scientific exchange, mentoring and career advancement. In addition, we need to understand that broadening participation is both about increasing the numbers of diverse participants and ensuring that they can fully contribute their expertise.

Today we are fortunate to have publications and resources for anyone wanting to understand more about the needs of underrepresented populations in science, technology, engineering and maths (Stem). To implement the needed changes, however, requires that we also challenge our own past norms and engage in evidence-based practices for creating positive experiences for a more diverse group of peers.

There are many actions before, during and after conferences that can drastically improve inclusivity (see box). The first step is to ensure that multiple perspectives are brought to bear on the way in which the meeting is designed by appointing an organising committee that reflects the diversity you are seeking.

We are all, whenever we attend a conference, responsible for enacting a culture shift towards inclusion

One way that conference organisers should remove barriers for attendance is by making sure the conference venue follows accessibility standards. Even if some venues have not updated their facilities, conference organisers can negotiate temporary fixes. For example, attendees of the 2019 annual conference of the Society for the Advancement of Chicanos and Native Americans in Science found temporary reassignment and signage of bathrooms to make them accessible and safe for all genders.

When planning the agenda of a scientific conference, a diverse speaker lineup should be prioritised. This is in recognition that whomever talks has the power. An equitable set of keynote speakers helps to advertise that the conference is welcoming and inclusive. Visual messaging is another crucial aspect of advertising to review. Nothing can be more counterproductive than a group photo of mostly able bodied, all white male attendees on a meeting website trying to solicit registrations from scientists from a wide range of backgrounds.

Clear messaging and support needs to continue throughout the conference. Opening remarks are important for setting an inclusive and welcoming tone, and can highlight and normalise the services available, such as quiet rooms or lactation rooms. In a similar vein, questions and discussions should be moderated in such ways that give equitable voice to participants regardless of career stage or social identities.

But its not just conference organisers who should work on making meetings more inclusive. We are all, whenever we attend a conference, responsible for enacting a culture shift towards inclusion. Each attendee has the opportunity and arguably the responsibility to treat all colleagues with openness, respect and collaboration. Actions you can take to support inclusion include being selective about which conferences you attend, prioritising those that demonstrate commitments to diversity and inclusion. Or you may choose to encourage conference organisers to adopt more inclusive practices. If you are unable to attend a meeting, you could recommend an alternate attendee who not only represents your area of scholarly expertise, but may also represent an underrepresented career stage or social identity.

In addition, we need scientific institutions, societies and organisations to foster a culture where colleagues are taught to lean in on issues of inequity to correct the harmful behavior of other colleagues. There are no bystanders: only those who are harmed, those who do the harm and those who let it be done.

Science is a team sport and meetings are our stadium

Such actions can significantly lessen the burden on those from underrepresented backgrounds, who often shoulder the work of advancing diversity and inclusion. We can only address underrepresentation and exclusion if we understand it as a collective problem that requires us all to commit to making conferences more creative and welcoming spaces. Science is a team sport and meetings are our stadium, and so it is critical we recruit and sustain diverse and complementary talents to avoid falling into rote patterns that lack innovation and inclusivity. Fostering diversity and inclusion in scientific meetings will enable a better scientific community, and thus
better science.

The guide Inclusive Scientific Meetings: Where to Start4provides anyone involved in organising scientific conferences with the knowledge and resources to make a difference, as well as background on the latest research on diversity, equity and inclusion in the Stem context. Written by a group of scientists and leaders in diversity, equity and inclusion in Stem, the guide was co-developed by 500 Women Scientists, the Earth Science Womens Network, and the Aspen Global Change Institute. Some of the tips it shares for organising inclusive events include:

Prioritise a diverse group of co-organisers, speakers and attendees

When organising keynotes, give female and underrepresented participants equitable standing with able-bodied, white men

Make sure your conference venue follows accessibility standards and has bathroom facilities for individuals from non-binary genders

Work with conveners to provide access to aid for travel and childcare

Review conference communications and advertising for inclusive language and visual messaging

Require attendees to agree to workshop rules of engagement and/or a code of conduct as part of registration

Ask for each participants preferred gender pronoun as part of registration, and include on official rosters and nametags

Use opening remarks to set an inclusive tone, for example by highlighting and normalising some of the available support

Post and publicise the conferences code of conduct around the venue

Identify staff or volunteers who can be contacted if the code of conduct is violated, and be clear about enforcement mechanisms

Establish equitable rules of engagement regarding discussion dynamics. How will questions be fielded?

Provide chairs for speakers and panellists

Use microphones and speakers during presentations and discussions to assist with auditory accessibility

Plan activities to help participants (especially those who are not already familiar with others in attendance) to connect with each other

Create open opportunities for conference attendees to contribute to post-workshop publications

Ensure appropriate attribution of conference-generated ideas

Document results on the effectiveness of inclusion-promoting strategies and share them through published meeting notes. Highlight lessons learned, recognise challenges, celebrate successes and honour everyones efforts. The notes can also serve as a valuable example for peer institutions, and inspire a broader systemic change.

Read more here:
Why diversity and inclusion at conferences matter | Opinion - Chemistry World

Mason Crosby on Green Bay Packers 6-1 record, chemistry: This is the way you want to start a season – WITI FOX 6 Milwaukee

The Green Bay Packers on Sunday at Lambeau gave the rest of the NFL its first true glimpse of what Matt LaFleurs offense can look like with Aaron Rodgers at the helm and it was scary. Rodgers had his best game by far under the new Packers coach, throwing for 429 yards and five touchdowns and running for another as Green Bay beat the Oakland Raiders 42-24 on Sunday. Rodgers completed 25 of 31 passes to eight different targets and finished with the first perfect passer rating of his career, leading LaFleurs offense to a season-high in points. Even with top target Davante Adams sidelined for the third straight game with turf toe, Rodgers threw for his most touchdowns in a game since Sept. 28, 2015, against the Chiefs.

Afterward, Rodgers called it the most complete that Ive played.

FOX6s Kaitlin Sharkey: Youve played with Aaron Rodgers for a long time. Youve seen his great games, great moments, and then he comes away with, Sunday, six touchdowns, are there any of these games or any of these times when you go, Like, is this really happening? Because hes had so many of these great moments, how does a game like Sunday stand out?

Yeah, I mean, hes not gonna have too many more opportunities to have records. Like, you know, its like, he just seems to have set, you know, pretty much all of them, so I didnt realize that hadnt been happening, or he hadnt done it. You know, I guess I wouldve assumed that hed probably had a perfect game at some point, or a perfect passer rating, but I mean, what a great teammate. What a great example of what it is to lead a team. Just goes out there and performs every game, every day, and you know you can count on Aaron to have a good game, and put it all on the line, so.

FOX6s Kaitlin Sharkey: And then looking ahead, the rhythm you guys have had on offense, just the way the team is playing, the chemistry, do you really feel like the sky is the limit for this team because things are starting to click? Everyones getting more comfortable with where theyre supposed to be, their roles, play calls, things like that?

I do, said Crosby. I mean, I dont think weve had a complete game on all three phases, and, you know, well all admit that we have a little bit more, we can tighten it down just a little bit more.

FOX6s Kaitlin Sharkey: Finally, were you disappointed you didnt get a Lambeau Leap on Sunday?

Yeah, you know, I kind of, honestly, I will look back at the film, said Crosby. I did take a dive, you know, on the extra point right before half, so, you know, Im trying to add a lot to, you know, my resume here, you know, as far as what I can do, but Ill take a 42-point game where, you know, I just have extra points all day. Thats OK with me.

44.501341-88.062208

Excerpt from:
Mason Crosby on Green Bay Packers 6-1 record, chemistry: This is the way you want to start a season - WITI FOX 6 Milwaukee

Rethinking Chemical Synthesis With Cell-free Biocatalysis – Technology Networks

Traditionally chemical synthesis is a lengthy, step-by-step, or rather "batch-by-batch", process. However, new technologiesand approaches are driving the pharmaceutical manufacturing industry forward with continuous processes now making the task of turning low-value materials into high-value therapeutics, quicker, more efficient and cost-effective, and cleaner.

Technology Networks recently had the pleasure of speaking withDebut Bio's CEODr Joshua Britton. We discuss the evolution of chemical manufacturing, key challenges faced by those working in the field, andthe benefits of combining biocatalysis and continuous manufacturing.Laura Lansdowne (LL): For some of our readers that may be less familiar with Debut Bio, could you tell us a little more about the company? Joshua Britton (JB): Debut Bio creates therapeutic molecules in a faster and cheaper manner while avoiding toxic metals and resultant waste streams. Our core technology relies on the combination of immobilized enzymes with continuous manufacturing in a cell-free environment.The company is built on the knowledge that nature has evolved enzymes for millions of years to perform bio-transformations to exacting specifications in a green and sustainable manner. To that end, weve created a platform for cell-free biocatalysis utilizing immobilized enzymes and continuous flow chemistry to help our customers rethink the way they perform chemical synthesis.

Our patented and scalable solutions help shift our partners away from batch manufacturing toward more sustainable, clean, and cost-effective methods of production.

By leveraging Debut Biotech's platform, pharmaceutical companies will no longer have to perform long and tedious syntheses when they want to create complex pharmaceuticals that resemble the molecules found in nature. Instead, they can simply use our enzyme-based system to turn low-value materials, such as glucose, into high-value therapeutics and intermediates in a sustainable manner.

When companies want to get the exact molecules found in nature with therapeutic benefits, they can again use our technology platform. As Debut Bio advances, we expect our platform capabilities to broaden to a large number of small molecule therapeutics that will allow quick, green, and cost-effective access to these value-added molecules.LL: What does traditional chemical manufacturing look like and how has chemical manufacturing evolved over the years?JB: The grand challenge of the twenty-first century is the transition to greener, more sustainable manufacturing processes that efficiently use raw materials, eliminate waste, and avoid the use of toxic and hazardous substances. At present, the pharmaceutical industry relies on a production process known as batch manufacturing that has remained the status quo for 75+ years. This lengthy step-by-step chemical vat process often requires using oil products, scarce metals, and costly intermediates. In short, batch manufacturing is dirty, slow, and expensive. In fact, it is estimated that the pharmaceutical industry alone wastes nearly $50bn per year on inefficient batch manufacturing processes. To remain competitive, many incumbent manufacturers are interested in partnerships that will allow them to transition to bio-based chemical production.Enter continuous manufacturing. In continuous manufacturing, a pump (or pumps) continuously passes a low value reactant solution through a reactor in which it is transformed. In our case, the reactor contains a large number of complex immobilized enzymes. After a set amount of time, the product exits the reactor and is collected. Continuous manufacturing often provides improved enzyme stability, reaction rates, selectivity, lifetime, and efficiency to cell-free systems, yet no continuous cell-free system exists. In general, continuous manufacturing is the distinct opposite to batch manufacturing.

In batch manufacturing, a reaction is started, it is run for a certain amount of time, and then the reaction is stopped. Then, the product is isolated and the whole process starts again. In continuous manufacturing, a solution is continuously passed through a reactor. As the solution enters one side of the reactor and then exits, it is transformed. In this sense, the reaction can run indefinitely and through a smaller infrastructure. Additionally, continuous manufacturing allows for quicker reaction times and better control, as well as the potential for analytical technology to follow the reaction in real time.LL: What are some of the main challenges faced by those working in the area of pharmaceutical manufacturing?JB: As I mentioned earlier, the pharmaceutical industry wastes $50bn per year on inefficient batch manufacturing processes; this can be dramatically improved. As pharmaceutical cost drives innovation into the pharmaceutical sector, new and improved methods that can create cost competitive routes to molecules of interest are welcomed.Additionally, while green chemistry principles are often emphasized as a driver, in our experience, this is often superseded by cost. If a company can offer better routes to pharmaceuticals with green chemistry at the core of its inception; that would be a welcomed advance.

In terms of continuous manufacturing and the pharmaceutical sector, there has been a lot of noise in this area over the past seven years. While there has been some great academic advances in continuous manufacturing that have been translated into industry (photochemical reactions, for example), many improvements published in continuous manufacturing systems offer only marginal advancements such as a reduction in reaction time or temperature; these have had less of an effect. We must remember that when researchers and companies talk about scale, many pharmaceuticals are created at a quantity that would not warrant continuous production.

In our experience, continuous manufacturing can offer consistency, stability, real-time monitoring and feedback and improved safety. While new routes are often created, the likelihood of a company changing its designated route to an active pharmaceutical ingredient is limited both by cost and regulatory reapproval; these systems must provide better benefits to see true adoption.

Finally, pharmaceuticals are becoming more complex as companies target both new and old diseases. As many of these molecules are adapted and inspired by natural products, synthetic chemistry and methodology must adapt and change to keep up with demand. While many of these transformations can (and will) be achieved in synthetic chemistry, what would it be like if these complex transformations could be achieved with enzymes? What happens if complex pharmaceuticals could be created by a simple enzyme sequence alone or coupled with a chemical step? What happens if we can make synthetic chemistry inferior to enzyme pathways for pharmaceutical creation - these questions drive us to new scientific levels.LL: What are the key benefits of combining biocatalysis and continuous manufacturing to create molecules?JB: When you combine an enzyme transformation with continuous manufacturing, you open a world of process benefits and consistency.For example, in continuous manufacturing systems the product of the reaction can be removed and so that the enzyme always sees a fresh solution of substrate; this can drive reactivity to new levels.

Additionally, coupling enzyme systems in continuous manufacturing systems have shown a decrease in side reactions (byproducts). When we immobilize enzymes for their use in continuous systems, we offer a range of benefits including improved stability, recyclability, selectivity, reaction rates, and the enzyme does not have to be removed from the product.

Finally, continuous manufacturing allows the enzyme system to be scaled in an economical and effective way to meet a demand. Compared to the large typical enzyme reactors. A continuous system could save dramatically on reactor footprint and cost.

Joshua Britton was speaking to Laura Elizabeth Lansdowne, Senior Science Writer for Tec
hnology Networks.

Continued here:
Rethinking Chemical Synthesis With Cell-free Biocatalysis - Technology Networks

Taking Ritalin to study may change brain chemistry – Futurity: Research News

For young people who dont have ADHD, recreationally taking Ritalin may lead to changes in brain chemistry associated with risk-taking behavior, sleep disruption, and other undesirable effects, a new study suggests.

Ritalin, the brand name for methylphenidate, a central nervous system stimulant used to treat ADHD (attention deficit hyperactivity disorder), is a growing problem among college students who use it without a prescription as a so-called study enhancer. The drug works by increasing the concentration of certain neurotransmitters in the brain that control reasoning, problem solving, and other behaviors.

Although Ritalins effectiveness in treating ADHD is well-documented, few studies have looked at the drugs effect on non-prescribed illicit use, says Panayotis (Peter) Thanos, senior research scientist at the Research Institute on Addictions at the University at Buffalo. We wanted to explore the effects of this stimulant drug on the brain, behavior, and development on non-ADHD subjects.

Recent studies put college students nonprescription use of stimulant drugs (Ritalin and amphetamines such as Adderall and Dexedrine) at rates anywhere between 14 and 38 percent, depending on the type of college and age of student. The common belief is that these drugs can help students to focus and concentrate when studying and perform better on tests. Alarmingly, these drugs are finding their way into high schools, as well, for the same reasons.

Thanos team looked at changes in the brains of rats who received regular doses of methylphenidate during what would be equivalent to adolescence in humans, a time of significant brain growth and development.

We saw changes in the brain chemistry in ways that are known to have an impact on the reward pathway, locomotor activity, and other behaviors, as well as effects on body weight, Thanos says.

These changes in brain chemistry were associated with serious concerns such as risk-taking behaviors, disruptions in the sleep/wake cycle, and problematic weight loss, as well as resulting in increased activity and anti-anxiety and antidepressive effects.

Further research indicated that female subjects were more sensitive to the behavioral effects of methylphenidate than the males.

Thanos hopes that studying the effects of methylphenidate on those without ADHD may lead to a greater understanding of how the drug works on the brain and behavior, and can help researchers understand the impact of the drug on young people throughout development.

Understanding more about the effects of methylphenidate is also important as people with ADHD show greater risk to be diagnosed with a drug dependency problem, Thanos says. In addition, this study highlights the potential long-range risks college students take in using Ritalin for a quick study boost.

This research appeared in the Journal of Neural Transmission in May and in Frontiers in Behavioral Neuroscience in March.

The New York State Research Foundation and the National Institute of Child Health & Human Development of the National Institutes of Health funded Thanos research. Coauthors are David Komatsu of Stony Brook University and Michael Hadjiargyrou of the New York Institute of Technology.

Source: University at Buffalo

Read the rest here:
Taking Ritalin to study may change brain chemistry - Futurity: Research News

Chemistry key to Shawnee tennis doubles team’s success – Lima Ohio

SHAWNEE TOWNSHIP Throughout the years at Shawnee, Indians head coach Steve Jones has often paired his top two singles players as a doubles team in order to enhance their chances of getting to state.

While on paper, it sounds like a formula for success it may not work if the chemistry is not right.

But that was not the case when Michael Rutter, the Indians No. 1 singles player throughout the year, and Isaac Hanover, the No. 2 player during the season, formed a doubles team at the onset of the postseason that has advanced to the Division II state boys tournament.

The Shawnee juniors will open state play against the Pepper Pike Orange pair of Santiago Bustamente and Rahul Krisman at the Linder Family Tennis Center in Mason on Friday.

The Indian duo won the district title Saturday by defeating the Archbold team of Jereme Rupp and Luke McQuade 6-0, 6-1 in the championship match.

I knew Michael had some nagging, small little injuries and I was a little worried about him going singles and all the abuse it was going to take on him so we basically decided that because of how he and Isaac played at the Port Clinton tournament where they won the entire thing in the A division we would put them together, Jones said. There was some chemistry there and some momentum behind those two.

Having started out playing doubles for Shawnee, both were familiar with playing doubles and it did not hurt that the two netters have known each other for quite some time so the transition to playing as duo was not difficult for either one.

Jones said the key to the pairs winning run during the postseason is that both are serious players who work hard in the off season to perfect their games. Primarily working with Jeff Brown, tennis director at Westwood Tennis and Fitness Center, the two have honed their skills.

Jeff works them pretty hard and works on things that he thinks are weaknesses and they end up sort of complimenting each other when they play together, Jones said. One of their weaknesses might be the other guys strength and visa versa.

Hanover and Rutter agreed that the positive experience playing at Port Clinton was the start of a doubles team that could be highly successful.

I thought we had great chemistry, said Hanover, who felt they had the potential to make a big run in the postseason. I thought we played really well against some tough competition and so that kind of led to the decision of playing in sectionals and districts.

Rutter reinforced Hanover and Jones sentiment that the duos showing at the Port Clinton tournament was instrumental in putting the two together for a possible postseason run.

We both have a great set of skills that we can use at the levels weve succeeded at, Rutter said.

At the onset of the sectionals, Hanover said he and Rutter looked at each other and said This is it. This is where we start. And from there the two said they would take it match by match and work together to break down their opponents and expose their weaknesses.

Hanover added the reasons the two work well together is their strong play at the net and they are great at finishing points.

Rutter, who narrowly missed state with his brother two years ago after falling in the district, said the primary goal was to make state. Another motivating factor for Rutter was upholding family tradition. All his brothers have advanced to state and now he has joined that elite group.

The brothers success really motivated me, Rutter said. Tim, Sam, Johnny all went to state one year and that was huge for me. I lost a match two years to go to state with my brother, Tim, against one of the kids we played in district to go to state so that really helped me in that match.

By the time they got to districts, the two began to iron out more of the kinks in the duos play. Another factor that came into play was the right mindset to play at the district level. While this was Hanovers first time, Rutter, who has been to districts three times, was there to offer a little insight of what it takes to win at the district level.

I think he (Hanover) has been doing great, Rutter said. I didnt have anything to say to him other than to do his job and he knows his job well and I am thankful to have him as a partner. The things he can do really help.

Hanover admits that the first day of districts was a little rough but by the second day they had worked out the kinks and dominated the opposition.

Getting over the district hump is a great accomplishment but at state the pair is going to face a whole new level of tough competition.

I think it is absolutely awesome that we have gotten this far, Hanover said. I would like to see us get to the second day of state which I think is very doable and we just have to keep doing what we have been doing and playing smart and playing aggressive.

Rutter added that the goal was to make state and see what they could do there.

Jones said if these two stay focused they can make some noise at state.

They need to play at the top of their game, Jones said. They cannot let anything go. They cannot slide in any way and they have to make sure they capitalize on every mistake the other team makes.

The Shawnee doubles team of Michael Rutter, left, and Isaac Hanover will be playing in the Division II state tennis tournament after capturing first at the Northwest district tournament held at Bowling Green State University.

http://limaohio.com/wp-content/uploads/2017/05/web1_Indian-pair.jpgThe Shawnee doubles team of Michael Rutter, left, and Isaac Hanover will be playing in the Division II state tennis tournament after capturing first at the Northwest district tournament held at Bowling Green State University.

Pair chase state title starting Friday

Reach Jose Nogueras at 567-242-0567 or on twitter @JoseNogueras1

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Chemistry key to Shawnee tennis doubles team's success - Lima Ohio

A fresh math perspective opens new possibilities for computational chemistry – Phys.Org

June 1, 2017 by Linda Vu This image shows the structure of berkelium in oxidation state +IV. Researchers used the new Berkeley Lab algorithm to calculate the absorption spectrum and confirm what what several experimental results have been hintingthat the element berkelium breaks form with its heavy element peers by taking on an extra positive charge when bound to a synthetic organic molecule. This property could help scientists develop better methods for handling and purifying nuclear materials. Credit: Bert de Jong, Berkeley Lab

Glow-in-the-dark objects seem magical when you're a kidthey can brighten up a dark room without the need for electricity, batteries or a light bulb. Then at some point you learn the science behind this phenomenon. Chemical compounds called chromophores become energized, or excited, when they absorb visible light. As they return to their normal state, the stored energy is released as light, which we perceive as a glow. In materials science, researchers rely on a similar phenomenon to study the structures of materials that will eventually be used in chemical catalysis, batteries, solar applications and more.

When a molecule absorbs a photonthe fundamental particle of lightelectrons in the molecular system are promoted from a low-energy (ground) state to a higher-energy (excited) state. These responses resonate at specific light frequencies, leaving "spectral fingerprints" that illuminate the atomic and electronic structures of the system being studied.

In experiments, the "spectral fingerprints" or absorption spectrum, are measured with state-of-the-art facilities like the Advanced Light Source (ALS) at the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab). In computer simulations, these measurements are typically captured with a quantum mechanical method called Time Dependent Density Functional Theory (TDDFT). The computational models are critical in helping researchers make the most of their experiments by predicting and validating results.

Yet despite its usefulness, there are times when TDDFT cannot not be used to calculate the absorption spectrum of a system because it would require too much time and computer resources. This is where a new mathematical "shortcut" developed by researchers in Berkeley Lab's Computational Research Division (CRD) comes in handy. Their algorithm speeds up absorption calculations by a factor of five, so simulations that used to take 10 to 15 hours to compute can now be done in approximately 2.5 hours.

A paper describing this method was published in the Journal of Chemical Theory and Computation (JCTC). And the new approach for computing the absorption spectrum will be incorporated in an upcoming release of the widely used NWChem computational chemistry software suite later this year.

New Algorithms Lead to Computational Savings

To study the chemical structure of new molecules and materials, scientists typically probe the system with an external stimulustypically a laserthen look for small electronic changes. Mathematically, this electronic change can be expressed as an eigenvalue problem. By solving this eigenvalue problem, researchers can get a good approximation of the absorption spectrum, which in turn reveals the resonant frequencies of the system being studied. Meanwhile, the corresponding eigenvector is used to calculate how intensely the system responded to the stimulus. This is essentially the principle behind the TDDFT approach, which has been implemented in several quantum chemistry software packages, including the open-source NWChem software suite.

While this approach has proven to be successful, it does have limitations for large systems. The wider the energy range of electronic responses a researcher tries to capture in a system, the more eigenvalues and eigenvectors need to be computed, which also means more computing resources are necessary. Ultimately, the absorption spectrum of a molecular system with more than 100 atoms becomes prohibitively expensive to compute with this method.

To overcome these limitations, mathematicians in CRD developed a technique to compute the absorption spectrum directly without explicitly computing the eigenvalues of the matrix.

"Traditionally, researchers have had to compute the eigenvalues and eigenvectors of very large matrices in order to generate the absorption spectrum, but we realized that you don't have to compute every single eigenvalue to get an accurate view of the absorption spectrum," says Chao Yang, a CRD mathematician who led the development of the new approach.

By reformulating the problem as a matrix function approximation, making use of a special transformation and taking advantage of the underlying symmetry with respect to a non-Euclidean metric, Yang and his colleagues were able to apply the Lanczos algorithm and a Kernal Polynomial Method (KPM) to approximate the absorption spectrum of several molecules. Both of these algorithms require relatively low-memory compared to non-symmetrical alternatives, which is the key to the computational savings.

Because this method requires less computing power to achieve a result, researchers can also easily calculate the absorption spectrum for molecular systems with several hundreds of atoms.

"This method is a significant step forward because it allows us to model the absorption spectrum of molecular systems of hundreds of atoms at lower computational cost." says Niranjan Govind, a computational chemist at the Pacific Northwest National Laboratory who collaborated with the Berkeley Lab team on the development of the method in the NWChem computational chemistry program.

Recently Berkeley Lab scientists used this method to calculate the absorption spectrum and confirm what several experimental results have been hintingthat the element berkelium breaks form with its heavy element peers by taking on an extra positive charge when bound to a synthetic organic molecule. This property could help scientists develop better methods for handling and purifying nuclear materials. A paper highlighting this result appeared April 10 in the journal Nature Chemistry.

"The experimental results were hinting at this unusual behavior in berkelium, but there wasn't enough experimental evidence to say yes, 100 percent, this is what we're seeing," says study co-author Wibe Albert de Jong, a CRD scientist. "To be 100 percent sure, we did large computational simulations and compared them to the experimental data and determined that they were, indeed, seeing berkelium in an unusual oxidation state."

This new algorithm was developed through a DOE Office of Science-supported Scientific Discovery through Advanced Computing (SciDAC) project focused on advancing software and algorithms for photochemical reactions. SciDAC projects typically bring together an interdisciplinary team of researchers to develop new and novel computational methods for tackling some of the most challenging scientific problems.

"The interdisciplinary nature of SciDAC is a very effective way to facilitate breakthrough science, as each team member brings a different perspective to problem solving," says Yang. "In this dynamical environment, mathematicians, like me, team up with domain scientists to identify computational bottlenecks, then we use cutting-edge mathematical techniques to address and overcome those challenges."

Explore further: Supercomputing mimics berkelium experiments to validate new find

More information: Jiri Brabec et al. Efficient Algorithms for Estimating the Absorption Spectrum within Linear Response TDDFT, Journal of Chemical Theory and Computation (2015). DOI: 10.1021/acs.jctc.5b00887

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A fresh math perspective opens new possibilities for computational chemistry - Phys.Org

Chemistry professor says goodbye after 43 years at UNM – UNM Newsroom

After more than four decades at The University of New Mexico, Department of Chemistry & Chemical Biology Professor Richard Holder is saying goodbye after a long and distinguished career.

The department is hosting a celebration to honor Holder on Wednesday, May 3 from 3 4 p.m. in the SMLC Atrium. All are welcome to attend.

A Wyoming native and graduate of Yale University, Holder came to UNM in 1974 as a tenure-track assistant professor after a stint at Vassar College in New York state. Over the next 43 years, he would go on to serve UNM in a variety of roles and make the jump into faculty administration, a move inspired by a year working as a program director with the National Science Foundation.

In 1986, Holder moved from a fulltime position in chemistry to UNMs Provosts Office where he stayed for 25 years, working in several positions including Deputy Provost and Dean of University College. And, while he never entirely gave up teaching, something he says had a positive impact on his administrative efforts, he says it was those years working in Provosts Office where he feels he made the biggest impact.

As an administrator, I always felt my job was to support the faculty, make life easier for them and make sure they had what they needed to succeed, he said. I think thats what faculty administrators are supposed to do and thats what I tried to do for all those years.

During his time in the Provosts Office, Holder oversaw tenure & promotions, the hiring process as well as student complaints and grievances. He says one of his most memorable accomplishments was helping bolster UNMs Honors College which, at the time, was not yet an accredited college. Today, hes proud of the fact that UNM has one of the most robust and successful Honors Colleges in the country.

Over the years, Holder saw nine Provosts come through the office, and while he enjoyed working at that level, helping shape the University in many ways, in 2011, he made the decision to leave the Provosts Office and go back to teaching fulltime.

I really enjoy teaching, I enjoy chemistry and I love working with the students, he said. Even though I kept teaching over the years, being a fulltime administrator really takes a lot of your attention so being able to come back to it has been great.

And its those relationships, the interactions with his students and fellow faculty members, he says he will miss the most.

But, even though he will officially retire after this semester, Holder says he wont completely disappear from campus. He plans to continue to work in the department and has not ruled out the possibility of teaching a class or two in the future. For right now though, he says hes looking forward to doing a bit of travelling and spending more time volunteering with the local horse rescue, Walkin N Circles Ranch.

The non-profit organization, which Holder is Board President of, rescues mistreated and abandoned horses, rehabilitating them before adopting them out to good homes. Its a cause he says is close to his heart.

Im originally from Wyoming, so doing something with horses is sort of a genetic thing, he said.

According to their website, Walkin N Circles has rescued more than 60 horses with 60 more currently at their ranch in the Edgewood area. Holder hopes to be able to dedicate more time to the organization and help it continue to grow and save more and more horses in the future.

As for UNM, Holder says hes grateful for everything the University has done for him and the relationships hes been able to build here. And while its not secret that UNM is facing some big issues across campus, he says its important to remember all the good things that happen here every day.

I think people need to remember that no matter whats happening at the administrative level and at Scholes Hall the faculty, staff and students are doing the work of the University and by in large, that work is continuing to happen in a great way, he said. We have a lot to proud of around here.

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Chemistry professor says goodbye after 43 years at UNM - UNM Newsroom

Despite chemistry of stars, Korean comedy ‘The King’s Case Note’ is easily dismissed – Los Angeles Times

Theres at least one hyphen too many where the intermittently entertaining South Korean historical-mystery-adventure-comedy-drama The Kings Case Note is concerned.

Theres a workable, quirky Holmes-Watson dynamic in this yarn about a king who sets out with the aid of a loyal but somewhat clueless savant assistant to unmask the perpetrators behind a nefarious conspiracy to dethrone him. However, the peripatetic tone fails to hold viewer attention.

When he takes a position as official royal historian, baby-faced scholar Seo (Ahn Jae-hong) doesnt quite realize that the job description goes considerably beyond chronicling each and every word of the glib King Yejong (Lee Sun-kyun).

Seos attention to detail and photographic memory comes in handy for the more pressing task at hand embarking on a caper that will pit them against a giant ghost fish, ominous scarecrows and lethal herbs, among other challenges.

Unfortunately, as choreographed by director Moon Hyun-Sung, the adventure seldom gets sufficiently up to speed, and on the occasions it threatens to come to life, the pedestrian action sequences fail to compensate for that lethargic pace.

Given the intriguing era (the story takes place during the 500-year Joseon Dynasty, which ended with Japans annexation of Korea) and relaxed comic chemistry between Lee and Ahn, one is left hoping for a case that isnt so mechanically open and shut.

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The Kings Case Note

In Korean with English subtitles

Rating: Not rated

Running time: 1 hour, 54 minutes

Playing: CGV Cinemas, Los Angeles; CGV Cinemas, Buena Park

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Despite chemistry of stars, Korean comedy 'The King's Case Note' is easily dismissed - Los Angeles Times