The researchers' conclusion that "the maximum lifespan of humans is fixed and subject to natural constraints" is sobering reading for those who dream that human ageing can one day be successfully hacked. But for evolutionary ecologists, it should not come as a surprise.

As well as striking a note of biological realism, this research also highlights how research on human ageing often neglects the insights available from evolutionary theory -- and particularly from a research field called "comparative life-history ecology".

This genre of research explains why mice and humans grow old at such different rates (more on why this is a problem for ageing research later). It aims to bring us closer to understanding the "ultimate" reasons why we age -- which in turn can tell us whether the hundreds of millions of dollars poured into ageing research are actually a good investment.

Strive as we might, an evolutionary perspective tells us that maximum lifespans will not be extended by simply solving one symptom of ageing after another.

Ageing -- or "senescence", to use the biological term -- is defined as a decline in physiological condition with age. You might wonder why natural selection allows this to happen at all. The answer is that senescence happens in a "selection shadow" -- that is, after organisms have already reproduced and passed on their genes. There is no real evolutionary penalty for failing to ward off the ravages of old age, because in animal populations relatively few individuals make it into their geriatric years anyway, thanks to predators, disease, hardship or bad luck.

Natural selection reaches a crescendo at sexual maturity, when most individuals in a population are alive and striving to produce viable offspring. This is the age at which the genetic baton is passed to the next generation. Unfortunately for those of us over 40, it's all downhill from here in terms of the evolutionary pressure to maintain a healthy body.

This knowledge -- that selection pressure changes with age in a way that depends not just on the expected lifespan but also on the timing of reproductive effort -- is fundamental to evolutionary theories of ageing. It is also fundamental to how we design and interpret the research that aims to help us prolong our own maximum lifespans.

Many of the species most frequently studied by biologists -- such as mice, flies and worms -- are chosen precisely because their short lifespans and fast generational turnover make them quicker and easier to work with. But their short lives and adaptable reproductive strategies actually make them unsuitable models for testing drugs or other anti-ageing interventions aimed at slowing human ageing.

In contrast, species with long expected natural lifespans (which have reduced their mortality risk by evolving to a large size, or being able to fly or hibernate, or having a large brain) have already invested strongly, and perhaps maximally, in protecting their cells from ageing. This suggests there is no "anti-ageing switch" available to flick for a species such as ourselves. Whether or not we have children, it seems we're already naturally geared to live as long as we possibly can.

If we take the ratio of a short-lived species like a mouse and apply it to humans, we would predict a maximum lifespan of about 400 years! But despite all of our efforts to push the boundaries through medicine and nutrition, humans (along with elephants and other highly durable animals) don't come close to these biblical lifespans.

If we are to break the evolutionary constraints on maximum lifespan in humans, we need to better take account of life-history ecology. This theory tells us that the causes of ageing are to be found not at the end of our lives, but at the beginning.

How our maximum lifespan is ultimately limited will be understood by research that seeks to answer why the pace of life varies so much among different animals. For me, this is the take-home message from this recent excellent research.

Christopher Turbill is a senior lecturer in animal ecology at Western Sydney University.

See the rest here:
Why humans lack an 'anti-aging switch' - CNN

Most people know the average person's memory dissipates during the aging process. University of Bonn scientists teamed up with academicians at The Hebrew University of Jerusalem to determine the impact of cannabis on the brain's aging process. These researchers determined cannabis reverses aging processes within the brains of mice.

The Findings

The study revealed that older mice reverted back to the state of 2-month old mice after being administerd an extended low-dose cannabis treatment. These findings are important as they show there are additional options for the treatment of dementia in humans. The study results were recently publicized in the Nature Medicine journal.

The Impact of the Aging Process on the Brain

The brain ages just like every other organ in the human body. The result of this aging process is a decrease in cognitive ability. As an example, people tend to find it difficult to pay attention to multiple things at the same time or learn new concepts/skills as they age. Though this is a normal process, it can also lead to dementia. Researchers have been searching for ways to mitigate or completely reverse this process. The scientists referenced above have reversed the processin mice with cannabis treatment. Mice have short life spans and show significant cognitive deficits after a year of life.

About the Study

The researchers provided mice with a small amount of THC. The low dose of cannabis treatment was selected so the mice did not experience a euphoric effect. THC is the active ingredient in cannabis. The treatment was provided to mice that were two months old, a year old and 18 months old. The treatment was applied across four weeks. The scientists then tested the animals' memory performance and learning capacity.

Mice provided with the placebo had the expected age-related memory and learning losses. Mice provided with cannabis exhibited cognitive functions equal to those of of two-month-old mice. The cannabis treatment totally reversed performance loss in mice. The scientists studiedthe gene activity and brain tissue of treated mice to determine exactly what sort of effect cannabis treatment had in particularly old mice.

Following treatment, the molecular signature did not match that of old mice. Instead, it was similar to young mice. Furthermore, the quantity of links in the brain's nerve cells increased. These cells are vital to one's ability to learn. The bottom line is that cannabis treatment turned back the molecular clock in mice and it might be able to do the same in humans.

What led up to the Research

The cannabis treatment success stems from years of intense research. The scientists found the brain ages more rapidly when mice are not equipped with functional THC receptors. Cannabinoid 1 receptors are best defined as proteins where substances halt and stimulate a signal chain. These receptors are the cause of the euphoric effects of THC in marijuana and hashish. THC replicates the effects of the cannabinoids that are naturally created in the body. Cannabinoids perform vital functions within the brain. As one ages, the number of cannabinoids produced in the brain decrease. As the cannabinoid system declines the brain ages quite rapidly.

The Next Step

The next logical step is for researchers to perform clinical trials to determine if cannabis also reverses the aging process in the brains of human beings. Cannabis is widely usedfor medical purposes.It is also possible that cannabis boosts cognitive ability in aging adults. Though mice are not exactly the same as humans, the research team believes cannabis treatment will prove to be an effective means of treating dementia suffered by human beings across the world.

Read more:
Cannabis Reverses Brain Aging - Anti Aging News

Question: How I can achieve dramatic, clear and smooth skin results?

Answer: Sun spots, wrinkles, enlarged pores, acne scarring and skin laxity are concerns of men and women of all ages. It used to be difficult to select the appropriate technology for each concern, as lasers are usually specific to only one condition. Patients used to have to undergo not just a series of treatments, but also a few different lasers to address all concerns.

The latest technology for skin resurfacing is the new Co2re laser by Syneron Candela, a very efficient and versatile laser for skin resurfacing with minimal downtime. Fractional lasers only treat a fraction of the skin at a time with microscopic laser beams, as they drill millions of holes in the skin creating columns of injury that heal with new and healthy skin. The depth of laser penetration determines what is being treated and the downtime.

Almost every medical spa offers fractional resurfacing, fraxel, profractional and active fx, to name a few but Co2Re is truly innovative in that it uses seven types of laser beams that penetrate different depths at the same time.

This means that various conditions can be treated simultaneously. It has up to seven treatment modes to treat a variety of skin issues, from dark sun spots to deep wrinkles and acne scarring. In addition, Co2re offers dramatic results with minimal discomfort after just one treatment.

For patient comfort, we apply anesthetic cream to the face 20 minutes prior to the procedure. Generally significant improvement may be achieved after only one treatment, but ultimately all patients have different needs and will have to be assessed during their consultations. For more information, call 561-655-6325.

Daniela Dadurian, M.D., specializes in anti-aging medicine and is an expert in non-surgical body-contouring techniques. She received her medical degree from the University of Miami School of Medicine and has traveled the world researching the safest and latest technologies on the market.

________________________________________

MD Beauty Labs Medical Spa and Wellness Center

320 S. Quadrille Blvd., West Palm Beach

Read the original post:
Co2re gives you clear, perfectly smooth skin - Palm Beach Post

CURE Pharmaceutical Adds Industry Veteran, Anti-Aging Specialist and Medicinal Cannabis Supporter, Alan Einstein, to Its Board of Directors

OXNARD, Calif., May 03, 2017 -- CURE Pharmaceutical (OTCQB:CURR), (CURE), a leading disruptive drug delivery technology company researching cannabinoid molecules for various healthcare applications, today announces the appointment of Dr. Alan E. Einstein to its board of directors.

Dr. Alan Einstein, grandson to famed physicist Albert Einstein, has been practicing medicine since 1996. Currently working at EMC2Care in Alpharetta, Ga., he is considered a thought leader in metabolic syndrome and its role in weight gain and overall health and longevity. He has also conducted extensive research utilizing umbilical cord blood stem cells, with an interest in Parkinsons disease and assisted Senator David Shafer in writing and passing Georgias only Cord Blood stem cell bill. Furthermore, in July 2006, Dr. Einstein was appointed to the, Commission for Newborn Umbilical Cord Blood Research and Medical Treatment by Georgia Governor Sonny Perdue.

We here at CURE Pharmaceutical are always looking for innovators to be a part of our board of directors, to help us understand the needs in specific treatment areas, said Rob Davidson, CEO of CURE Pharmaceutical. Dr. Einsteins addition to our board allows for increased depth in our medical expertise as we continue to work to expand our technical capabilities across all these specific areas. We look forward to utilizing his specific knowledge and experience as we continue to rapidly grow.

Along with his work and knowledge in the areas of anti-aging and anti-inflammatory medicine, Dr. Einstein is a firm believer in the study of cannabis and cannabinoids for medicinal benefits. CURE is taking a leadership role in optimizing plant based cannabinoids with a strategy to bring new cannabinoid molecules to the market through the FDA regulatory approval process while utilizing the companys proprietary delivery technologies.

I am looking forward to being a part of CURE Pharmaceuticals board of directors. Their drug delivery technologies are innovative technologies that I believe will benefit a growing number of people who require alternate ways to take medications, instead of the standard pill, Dr. Einstein said. Additionally, I am excited to see the upcoming research and partnerships that the company is planning in the medicinal cannabinoid area, as this is a growing market area that needs more research to help prove the benefits of these molecules.

Dr. Einstein earned a bachelors of science degree in Physical Chemistry from The University of Florida. Subsequently, he earned his medical degree from The College of Osteopathic Medicine and Surgery in Des Moines, Iowa. Dr. Einstein then went on to complete his Internship and Residency training at The Johns Hopkins University School of Medicine/Sinai Hospital program in Internal Medicine, in Baltimore, MD.

About CURE Pharmaceutical Cure Pharmaceutical is a fully integrated specialty pharmaceutical/bioscience company with disruptive proprietary drug delivery technologies for a broad range of molecules serving the pharmaceutical, biotech, veterinarian, medical foods markets, cannabinoid molecules and new chemical entities (NCEs). Cure has an industry leading full service cGMP manufacturing facility and is a preeminent developer and manufacturer of a patented and proprietary delivery system (CureFilm), the most advanced oral thin film on the market today. Cure has developed an array of products in cutting-edge delivery platforms. Cure is well positioned in thepharmaceutical cannabis sector and is developing a global footprint with partners in the U.S., Canada, Israel and Germany, among other markets. The Companys mission is to create solutions to improve the overall quality of life and deliver proven drugs in a fast and efficient manner.

For more information about CURE Pharmaceutical, please visit its website at http://www.curepharmaceutical.com.

Forward-looking statements This press release contains forward-looking statements, which are subject to risks and uncertainties. All statements, other than statements of fact, including those statements with respect to the Company's business development, are forward-looking statements.Forward-looking statements speak only as of the date made and are not guarantees of future performance. We undertake no obligation to publicly update or revise any forward-looking statements.

Human Life Could Be Extended Indefinitely, Study Suggests

Goosebumps, tears and tenderness: what it means to be moved

Are over-the-counter painkillers a waste of money?

Does an anomaly in the Earth's magnetic field portend a coming pole reversal?

Immunotherapy: Training the body to fight cancer

Do vegetarians live longer? Probably, but not because they're vegetarian

Could a contraceptive app be as good as the pill?

Some scientific explanations for alien abduction that aren't so out of this world

Society actually does want policies that benefit future generations

Six cosmic catastrophes that could wipe out life on Earth

Big Pharma Starts Using Cannabis For Making Drugs In Earnest

Do you need to worry if your baby has a flat head?

More:
CURE Pharmaceutical Adds Industry Veteran Anti-Aging Specialist and Medicinal Cannabis Supporter Alan Einstein to ... - EconoTimes

Recent research, led by assistant professor of stem cell biology and regenerative medicine at the University of South Carolina Joseph T. Rodgers, has found a way to increase the bodys ability to heal after injury. The study was published in the scientific journal Cell Reports.

The research was funded by grants from the National Institutes of Health. Funding was also secured from the Donald E. and Delia B. Baxter Foundation, Glenn Foundation for Medical Research, and the Department of Veterans Affairs. The study was co-sponsored by the Department of Neurology and Neurological Sciences at Stanford. Clinical Research

In previous research, Rodgers proved that adult stem cells enter an alert state when the body sustains an injury. Alert stem cells have greater ability to heal and repair damaged tissues.

Rodgers theorized that blood from an injured person could produce a state of alert in another persons stem cells. Using lab mice, he and his team injected healthy mice with blood from their injured counterparts. The stem cells of the healthy mice were observed to adopt the state of alert.

The team was able to expose the chemical mechanism used to signal cells to enter an alert state as the enzyme Hepatocyte Growth Factor Activator (HGFA). HGFA is always present in the bloodstream but does not activate until the body experiences an injury. Once an injury occurs, the enzyme signals adult stem cells to enter the alert state.

Implications for Repair Response in the Injured Body

Once these findings were discovered, Rodgers team decided to investigate what would happen if an injury was sustained while the adult stem cells were already in a state of alert.

HGFA was injected into healthy mice. Several days later, the mice were given skin or muscle injuries. Test subjects were observed to heal faster, regrow missing fur, and return to running on exercise wheels sooner.

This research supports the idea that the presence of HGFA in the bloodstream prepares the body to respond more quickly and efficiently to injury. Similar to the way vaccines prepare the body to fight specific diseases, HGFA readies cells to respond to tissue damage.

Future Applications

In the future, people may be able to use HGFA before they engage in activities that could result in injury, like sports, surgery, or battle. HGFA could also be used in a therapeutic capacity for those with compromised healing abilities, like diabetes patients or senior citizens.

Forthcoming studies will explore how HGFA affects declines in the ability to heal, and how to use it to restore normal healing abilities.

Read the original here:
Triggering Stem Cells for Accelerated Healing - Anti Aging News

For caucasians, it's wrinkles and age spots

Juta/Shutterstock"My caucasian patients tend to commonly present in their early 30s with wrinklesparticularly around the eyes or glabella (between the eyebrows)," says board certified dermatologist Manjula Jegasothy, MD, founder of Miami Skin Institute, who has been treating ethnically diverse patients for 20 years. "This is easily treated with Botox in the 30s and early 40s." She also suggests adding light radiofrequency treatments in the mid to late 40s to help with thin skin laxity in the upper face. Sun damageresulting in brown spots and blotchinessis another common complaint. She suggests getting a jump start in the early 20s and 30s with pyruvic, salicylic, and glycolic acid peels. Try: Dr. Dennis Gross Skincare Alpha Beta Universal Daily Peel and BeautyRx by Dr. Schultz Advanced 10% Exfoliating Pads. Patients in their late 30s and olderand those with more severe damageshould consider in-office IPL photofacials. This is how your skin ages through every decade of your life.

Click-Images/ShutterstockThe majority of Dr. Jegasothy's patients are Latina, and the culture is very focused on body image. "I find that these patients are much more focused on non-surgical treatment of scars," Dr. Jegasothy says. For best results, scars should be treated as soon as possiblewithin the first two years; ideally as early as three weeks after the incision has healedwith a combination of Vbeam and Fraxel laser. Since Miami is a city with warm temperatures year round, her Latin American patients tend to be more concerned with skin laxity issues and celluliteparticularly on the thighs and buttocks, the areas that show in shorts. For both of these issues, Dr. Jegasothy recommends radiofrequency treatments with the Viora laser. Ever wondered why is cellulite so dang hard to get rid of?

Content continues below ad

Dragon-Images/Shutterstock"My AsianChinese, Japanese, and Koreanpatients are interesting because they are very concerned with trying to become an idealized version of a caucasian with features common in the Asian press," says Dr. Jegasothy. As such, the most common Botox procedure she performs on her Asian patients is softening the jawline muscle to create a more oval or round appearance. Another common beauty request of her Asian patients is for their facial skin to be as fair as possible. To this end, she does skin lightening chemical peels and topical herbal agents, such as SkinMedica Lytera 2.0 Pigment Correcting Serum as often as possible."

Prostock-studio/Shutterstock"I have been treating Indian patients for over 20 years, and by far the most common complaint is excessive hair on the face and body," notes Dr. Jegasothy. She stresses the importance of using the correct lasers and settings for the various skin tones, since those that are too strong can cause hyperpigmentation that can persist for up to a year. Her preference is the Candela GentleYag Laser. (Don't miss the 14 things you need to know before you get laser hair removal.) The second most common issue is dark under-eye circles. When patients are young, this can be successfully treated with mild cortisone creams and peptide eye creams, such as Neocutis Micro-Eyes. "As patients age, if they have hollowing along the orbital bone (which is the lower eyelid rim), and filler can make the under-eye circle seem less prominent." More often however, she finds that light Fraxel treatments (repeated every four to 12 months, depending on severity, genetics and age), can improve this situation enormously. These are the secrets to aging gracefully.

sruilk/ShutterstockAccording to Dr. Jegasothy, Middle Eastern patients primarily have the same issues as Indian patients: excess hair at an early age and dark under eye circles, which are treated in the same fashion. "In addition, Middle Eastern mores dictate that patients have a certain eyebrow type, which is quite plucked at an early age. As the trend today is toward fuller brows, I'm seeing more Middle Eastern patients in early to middle age who are looking for more eyebrow hair." For this, she recommends Latisse, a topical hair-growth serum available by prescription. Find out the best brows for your face shape.

Content continues below ad

Continued here:
Subscribe to Print: - Reader's Digest

(MENAFN Editorial) Hermann Wellness, an anti-aging treatment medical spa with locations in Tampa and St. Petersburg, recently launched its newly redesigned and restructured website at http://doctorhermann.com.

Hermann Wellness, led by Dr. Anne Hermann, M.D., provides the best and most comprehensive aesthetic medicine services in the Tampa Bay area. It is Dr. Hermann's mission to enable each of her patients to achieve optimal health by combining cutting edge technology and the latest research with compassionate medical care. Now, Hermann Wellness offers visitors and patients an updated and redesigned website for an enhanced browsing experience.

The newly designed Hermann Wellness website, found at http://doctorhermann.com, offers users a comprehensive menu with detailed information about each of the more than 50 services that Dr. Hermann has to offer. This interactive site also offers informative videos from Dr. Hermann herself, an online scheduling tool, and reviews from past patients. Overall, the new design and fresh content highlight the true impact that Dr. Hermann and her team can make to improve her patient's overall health offering treatments that address overall wellness and beauty from the inside out.

Dr. Hermann has more than 17 years of experience in internal, holistic, and cosmetic medicine. She obtained her Board Certification in Internal Medicine in 2000, then trained as a medical acupuncturist at UCLA Medical School and Professional Hypnologist at the Cord Institute of Hypnosis in 2004. Dr. Hermann also became Board Certified as a Physician Nutrition Specialist in 2004. Since then, she has completed advanced training in botox, dermal fillers, and other cosmetic procedures, and she has continued to grow her expertise within the holistic approach to medicine.

With two locations in Tampa and St. Petersburg, Hermann Wellness is conveniently located for all patients seeking customized care for aesthetic treatments, weight loss services, integrative medicine, and much more. Dr. Hermann's extensive training and experience in aesthetics and weight loss has made Hermann Wellness Tampa Bay's leader in cosmetic services and physician assisted weight loss and nutrition.

Anti-aging PRP injections, dermal fillers, and micro-needling skin resurfacing to the Optifast weight loss plan and Detox Diet, Hermann Wellness offers all of the essential services that help patients achieve the health and confidence they have always wanted.

Members of the community or media interested in learning more about Hermann Wellness and its newly designed website are invited to use the following contact information:

NAME: Dr. Anne Hermann, M.D. ADDRESS: 3040 W. Cypress St., Suite 103, Tampa, FL 33609 or 6387 Central Ave, St. Petersburg, FL 33710 PHONE: (813) 902-9559 (Tampa) or (727) 278-3992 (St. Petersburg) WEBSITE: http://doctorhermann.com EMAIL:

Go here to see the original:
Hermann Wellness of Tampa and St. Petersburg Launches Newly Designed Website - MENAFN.COM

Researchers in India report that yoga postures, breathing disciplines and meditation may be the key to prolonging that proverbial fountain of youth. Biomarkers found in human blood samples drawn during a clinical trial showed the anti-aging benefits of practicing these ancient holistic practices.

In the Yoga and Meditation Based Lifestyle Intervention (YMLI) clinical trial, scientists enrolled a homogenous, seemingly healthy group of 96 men and women aged 30-65 years old, who had not experienced any significant lifestyle or physical challenges over the preceding three months between August 2015 and May 2016. Once enrolled, participants had 5 milliliters of fasting venous blood drawn to establish baseline markers for a range of primary and secondary aging characteristics. They next practiced yoga and meditation in the 12-week program to measure the disciplines anti-aging benefits.

During the trials initial 14 days, the group received instructions from registered, specialized yoga instructors for five days each week at the AIIMS health clinic in New Delhi, India. The YMLI instructions incorporated Hatha and Raja yoga techniques including physical postures, breathing exercises and meditation into their 90-minute classes. Following yoga, a 30-minute lecture focused on the importance of a healthy lifestyle and diet in warding off conditions like cancer, diabetes and cardiovascular diseases, among others.

The participants then were required to continue their practices at home for the subsequent 10 weeks and were responsible for self-monitoring their progress in a diary or by regular telephone conversation. At the trials conclusion, another 5 milliliters venous blood was drawn to compare the pre- and post-YMLI levels of various markers.

The scientists analyzed the changes in primary and secondary aging characteristic found in participants blood before and after the 12-week program. Primary measures included DNA damage that leads to metabolic instability, oxidative stress levels, total antioxidant levels, among others. As secondary factors, they examined cortisol levels a reading of stress responsiveness inflammation and cellular plasticity, among others.

The researchers hypothesis was confirmed when they examined the trial participants blood at the end of the 12-week trial. In every instance, YMLI was associated with changes for the better, indicating a slow-down of the cellular aging process. The authors hailed their clinical trial as the first to investigate the effects of YMLI on age-related biomarkers. Almost no gender-based biomarker differences appeared in the trial. This trial serves as a springboard bringing the practice of yoga and meditation further into mainstream science surrounding aging and disease prevention.

The study is limited by its small size, homogenous population and lack of a similarly sized control group.

The trials findings were published online on Jan. 16, 2017, by Oxidative Medicine and Cellular Longevity.

So, you may want to bend and twist into a yogic position, breathe deeply and meditate in your individual quest to recapture that elusive fountain of youth.

Written By:Susan Mercer Hinrichs, MA, MBA, CPhT

Read more here:
Anti-Aging Benefits of Yoga - Medical News Bulletin

In 2013, Time magazine ran a cover story titled Google vs. Death about Calico, a then-new Google-run health venture focused on understanding aging and how to beat it. We should shoot for the things that are really, really important, so 10 or 20 years from now we have those things done, Google CEO Larry Page told Time.

But how exactly would Calico help humans live longer, healthier lives? How would it invest its vast $1.5 billion pool of money? Beyond sharing the companys ambitious mission to better understand the biology of aging and treat aging as a disease Page was vague.

I recently started poking around in Silicon Valley and talking to researchers who study aging and mortality, and discovered that four years after its launch, we still dont know what Calico is doing.

I asked everyone I could about Calico and quickly learned that its an impenetrable fortress. Among the little more than a dozen press releases Calico has put out, there were only broad descriptions of collaborations with outside labs and pharmaceutical companies most of them focused on that overwhelmingly vague mission of researching aging and associated diseases. The media contacts there didnt so much as respond to multiple requests for interviews.

People who work at Calico, Calicos outside collaborators, and even folks who were no longer with the company, stonewalled me.

We should pause for a moment to note how strange this is. One of the biggest and most profitable companies in the world has taken an interest in aging research, with about as much funding as NIHs entire budget for aging research, yet its remarkably opaque.

Google also prides itself for being a leader on transparency and for its open culture. And were living in a time when the norms in science, particularly biomedical science, are centered around openness and data sharing. But these values have somehow eluded Calico.

For now, I think its safe to say Google has not solved aging. Or if it did, they havent told anybody.

Its not unusual for new startups to be stealthy for a period while they get going, but theres usually some public statement with specific details about the technology or science being developed, strategies and targets. That Calico wont say what its doing bothers leading aging researchers. They expressed confusion or frustration about Calicos stealthiness, and said the secrecy is not productive for science.

Eric Topol is a cardiologist who studies aging and the director of Scripps Translational Science Institute. Topol knows some of the scientists at Calico from their pre-Calico days. Theyre hyper secretive, he said. Since they moved to Google, he cant seem to reach them. I have invited them to speak at our program we have on genomic medicine. They say no, they cant talk about what theyre doing. I am not sure why thats the case.

There were no clinical trials or patents filed publicly under the Calico brand that I could find, and out of the 22 papers published by the company and its affiliates, only about half related to aging and many were review articles (not original research).

Nir Barzilai, a geneticist and one of the leading researchers in aging based at Albert Einstein College of Medicine, said the publications didnt give him any special insights into what Calico is up to. Our field is interested in delaying aging and by that, delaying disease. [It seems] they are not doing that, he said. Its weird they dont come to us, look at our patents We have resources, we are eager to do partnerships and form bio-techs. And nobody from Calico talks to us.

Other top researchers on aging told me much the same. I dont interact with them, Felipe Sierra, director of the division of aging biology at NIHs National Institute on Aging, said. They dont want to interact with me. I ignore them as much as they ignore me. He also invited Calico scientists to present at NIH. They come to the meeting but they dont talk about what they are doing [They] wouldnt even talk about general directions [of their research].

There are a few potential explanations for Calicos secrecy. Among them: that Calico is just waiting for a big reveal. A December article in the MIT Technology Review, which was also scant on details about Calicos anti-aging science, hinted that might be the case:

[David] Botstein [the Calico Chief Scientific Officer] says a best case scenario is that Calico will have something profound to offer the world in 10 years. That time line explains why the company declines media interviews. There will be nothing to say for a very long time, except for some incremental scientific things. That is the problem.

But avoiding media hype does not require secrecy among scientific colleagues. If Calicos scientists were truly interested in pushing the boundaries of science, they might think about using some of the best practices that have been developed to that end: transparency, data sharing, and coordinating with other researchers so they dont go down redundant and wasteful paths.

As Topol said, Secretive research is pass. The world has moved on to fully demonstrate the value of openness, transparency, and avoidance of insular thinking.

There are other possible explanations for the stealthiness. A recent news release from Calico announced a partnership with C4 Therapeutics to work on coming up with drugs for "diseases of aging," such as cancer one of a number of drug company partnerships Calico has formed. If Calicos now focused on drug development, then a degree of secrecy might make sense. (Drug companies typically develop their products quietly to stay ahead of the competition.)

But researchers dont buy that explanation, either. The researchers [Calico] hired are using models such as yeasts, nematodes, and naked mole rats, said Barzilai. These are not the models that are relevant for drug development. Developing cures also doesnt fall in line with the companys original mission to treat aging as a genetic disease instead of hunting for treatments for age-related diseases.

Another potential reason for the lack of transparency the one I find most compelling is that its the company culture. Art Levinson, the CEO of Calico, is also chair of the board of Apple Inc. and was close to Steve Jobs, who was renowned for his clandestine approach to research and development and running a business. Its possible that Levinson has made secrecy part of Calicos DNA, the way its part of Apples DNA.

Perhaps Calico will one day justify its secrecy, Topol said. But at this point, he added, I dont understand it. Potentially withholding information about advances in biomedical science or cures for diseases is unacceptable: Lives are ultimately at stake. Anything that slows down progress in biomedical research cant be condoned.

For that reason, Id like to humbly invite Calico or people who have worked with the company to share what they are up to. I promise we wont hype it.

Have information about Calico? You can send me tips over email at julia.belluz@vox.com or secure PGP. (My key: 0AC1 64FA E095 851B 112A 0670 6D24 B5A4 56ED 285E)

Update Friday April 28, 2:34 p.m.: Thanks to reader tips and additional searches in PubMed, weve located and linked to several Calico papers we werent aware of when we first published this story on Thursday. I flagged the papers with the researchers quoted in this story who said they did not change their assessment of Calico.

See the article here:
Google is super secretive about its anti-aging research. No one knows why. - Vox

According to statistics, European womens and mens skin begin to enter into the anti-aging process at the age of 25 and 27, respectively. Anti-aging cosmeceuticals have been more and more favored in the market. Skin aging is the result of endogenous aging and exogenous aging. The initial anti-aging skin care products were mainly based on application of vitamin, such as the brand Dr. Brandt Skincare in America. At the beginning of the 21st century, extraction of active substance from plants had been widely used in the anti-aging skin care products, among which the brand SkinCeuticals was the most famous one. With the development of gene therapy and biological cell therapy technology, however, the biological cell therapy technology has been gradually applied to cosmeceuticals, among which the British brand ROSTHERNE is the representative.

ROSTHERNE is one of three main cosmeceutical brands (ROSTHERNE, HENLEAZE and VINSTRA) of EVIGT SOLSKIN COSMECEUTICALS CO., LTD. Different from the three elements of anti-aging namely precaution, protection and restoring emphasized by SkinCeuticals, ROSTHERNE focuses more on four dimensions namely restoring, fading, activation and strengthening for anti-aging research, and pays more attention to the main direction of refreshing normal physiological function of cell by human cell engineering and biomedical technology, so that youth could be continued fundamentally.

The story behind ROSTHERNE brand

ROSTHERNE brand originated from Rostherne Mere, the British National Nature Reserve and seclusion of the nobility for more than a hundred years, behind which the legend of immortal mermaid could be found. The Doctor of Medicine Jones and the aristocratic princess Ansel escaped from the manor for love and lived a displaced life. In order to make Ansel who became toilworn day by day rejuvenative, Dr. Jones came to Rostherne Mere each Easter to wait the mermaid who could give the secret of being immortal. Finally, he heard the lively bell under the water and saw rebirth of all things, so he extracted the most original anti-aging product from the native plant around the lake and let Ansel recover her youth look. They established a clinic of love to remember the mermaid with gratitude for her gift. The land around the clinic was planted with many roses, so that their love could be transmitted and the beauty could be lasting.

The anti-aging products of ROSTHERNE were developed by a group of professional dermatologists and researchers in the fields of cell, molecular biology and biophysics. And a series of effective anti-aging products were developed by them with their unique cell activation and regeneration technology as the core technology. The unique new technology of Renee Expert TM combines various plant stem cells, EGF, yeast extract, coenzyme Q10 and other anti-aging and anti-oxidation products with theory of biological cell medicine, and realizes promotion of 3D anti-aging by its superb technology. It fully activates collagen and makes the damaged skin recover its vitality.

The anti-aging effect of ROSTHERNE has been spread from England to the whole world. Today, ROSTHERNE has been introduced into America, France, Germany, Netherlands, Australia, New Zealand, Canada and Hong Kong successively. It has been increasingly praised highly by dermatologists, medical cosmetology industry and customers worldwide. ROSTHERNE constantly explores the active anti-aging elements of the ultimate effect with a rigorous scientific attitude, keeps its leading position in the anti-aging industry, and transmit Dr. Joness spirit of Sharing love, lasting beauty.

Media Contact Company Name: EVIGT SOLSKIN COSMECEUTICALS CO., LTD Contact Person: Ryan Email: Evigtsolskin@outlook.com Phone: +44?0?1428 656600 Country: United Kingdom Website: http://www.evigt-solskin.com

See the article here:
ROSTHERNE, LEAD THE MEDICAL ANTI-AGING - Press Release ... - Digital Journal

Researchers at the University of Connecticut have discovered a chemical compound that could lead to new treatments for diabetes and gastrointestinal conditions. The research team, led by Professor of Immunology and Medicine Pramod Srivastava from the University of Connecticut School of Medicine, published their official findings in the April 24 issue of the Proceedings of the National Academy of Sciences journal.

Anandamide Production

Capsaicin is a chemical compound contained in spicy chili peppers. This chemical is responsible for the sensation of heat felt when they are consumed. The chemical binds to brain receptors, called TPRV1 receptors, to signal the sensation of heat from the tongue to the brain. TPRV1 receptors are also found in the gastrointestinal tract.

As part of their research, the team administered capsaicin to lab mice. These mice were found to have less inflammation in the gastrointestinal tract. Some mice who previously showed signs of Type 1 diabetes showed normal blood sugar levels after the trials.

The results are contributed to the capsaicin binding with TPRV1 receptors in the gastrointestinal tract. The binding process prompts the receptors to produce the chemical anandamide. This chemical soothes and relaxes the gastrointestinal tract. Researchers could repeat their original results by feeding anandamide directly to the lab mice, rather than using chili peppers.

Researchers do not fully understand how the chemical causes the immune system and brain to interact.

Anandamide and cannabinoids are chemically similar. When a person consumes marijuana, anandamide receptors in the brain react to the presence of cannabinoids. This produces feelings of euphoria and relaxation, or a high. Marijuana consumption causes anandamide production.

Anandamide and the Gastrointestinal Tract

While the team has not uncovered the mechanism that allows the brain to communicate with the immune system, they do understand how it helps heal the gastrointestinal tract.

There are other receptors that react to anandamide. These signal the production of immune cells called macrophages. These cells reduce inflammation. Higher anandamide levels correlate with higher macrophage presence, which can mean a significant reduction in inflammation. Anandamide and macrophage production can positively affect conditions in the esophagus, stomach, and pancreas.

Current trials are testing the effect of anandamide on conditions affecting the lower gastrointestinal tract, such as colitis.

Future Trials

Current federal marijuana regulations make clinical trials using human subjects difficult. Researchers are hoping to partner with the state of Colorado to obtain statistics on the effect of edible marijuana on colitis sufferers. That evidence could support the use of medicinal marijuana to treat severe gastrointestinal disorders.

Future research will focus on finding the specific molecular pathway anandamide uses to send signals between the stomach and the brain. The team is also investigating how anandamide reacts with other receptors, and the functions they serve.

Nandini Acharyaa, Sasi Penukondab, Tatiana Shcheglovaa, Adam T. Hagymasia, Sreyashi Basua,1, and Pramod K. Srivastavaa,1, April 24 issue of the journal Proceedings of the National Academy of Science, Endocannabinoid system acts as a regulator of immune homeostasis in the gut, Nandini Acharya, doi: 10.1073/pnas.1612177114

See more here:
Chili Pepper and Marijuana Soothe Gut Inflammation - Anti Aging News

Japan, with its rapidly ageing population, has an obvious interest in developing regenerative medicine technology.

Bold, world-leading reform is not something usually associated with Japan or its latest policy push, Abenomics.

But there is one area where the country and its unusually long-serving Prime Minister, Shinzo Abe, can claim global leadership and that is in the field of regenerative medicine.

This relatively new area mostly involves using stem cells and the bodies own healing mechanisms to regrow cartilage or tissue and thereby avoid the need for surgery in difficult to fix areas like shoulders and hips.

Japan, with its rapidly ageing population, has an obvious interest in developing such technologies and has cleared away onerous regulation around clinical trials to kick-start the regenerative medicine industry.

"It was such a radical step," said Paul Anderson, the managing director of the ASX-listed Orthocell.

"And it has totally transformed the industry which has enabled Japan to drawn in capital and technology from around the world."

Buoyed by this success Japan is now looking to convince other countries, including Australia, on the merits its "light touch" regulation, while also looking to commercialise world-leading treatments.

That saw a delegation from the Australian industry accompany Trade Minister Steve Ciobo to Tokyo last week, where they met with Japanese regulators and companies who sold them on the benefits of commercialising their technologies in Japan.

Not that Anderson from Orthocell or John Martin, the chief executive of Regeneus - which is also listed on the ASX - needed much convincing.

"Japan wants to get in early on this revolution," said Martin.

"They are looking to hoover up all the best technologies from around the world and Australia seems to have a lot of them."

This would be a surprise to many given all the teeth gnashing around the lack of innovation in Australia. But contrary to the prevailing narrative it seems Australian companies have once again found a way to get in on the ground floor of a new, fast growing industry as the likes of Cochlear, ResMed and CSL did before them.

The ASX-listed Mesoblast, which was also on the trip to Tokyo, is the world's largest pure play stem cell company, and has had some recent success around treatments for heart failure.

Then come the likes of Orthocell, which recently did a deal with global giant Johnson & Johnson, while in December Regeneus struck a $US16.5 million agreement to license one part of its arthritis technology with Japan's AGC Asahi Glass.

The issue for Australia is that while it has a strong cluster of early stage companies in the space, the local regulatory environment is not as bold or progressive as that in Japan.

"If your regulations are too tough you stifle innovation," said Anderson from Orthocell.

And so the local industry is now pushing for Australia's Therapeutic Goods Administration to adopt the same licensing environment as Japan.

"If you asked me what I really wanted .... it would be that licensed in Japan meant licensed in Australia," said Martin, who was previously a partner at law firm Allens.

This is some way off and would be a big step for the TGA as the radical part of the Japanese approach was how it turned conventional regulatory practice on its head.

Having missed the earlier antibody revolution (mainly around cancer drugs), Japan is betting big that regenerative medicine is the way of the future.

It aims to roughly halve the time it takes to commercials drugs.

This is done by licensing early stage technologies, which are proven safe, then giving them five to seven years to show they can have a meaningful health outcome.

Critics argued this could legalises inefficient treatments, but the Japanese saw the problem through a different lens and decided the cost of delaying true anti-aging therapies was greater than the risk of approving ineffective treatments.

"When Japan first did this it was considered radical and dangerous," said Martin.

"Now there is an emerging view that cell therapies will replace steroids for a wide range of inflammatory conditions."

This push to make Japan a world leader is being led by Abe himself, who has likened Japan's fight against ageing to the battle waged by the US against cholera in the 19th century.

"I will lead the efforts to carve out a new horizon for the latest medical technologies, including regenerative medicine and innovative drug development, through a streamlined system from research to practical application in which the public and private sectors work together," Abe told the Japan National Press club in April 2013, during a speech in which he laid out his vision for the country.

For Abe the push into regenerative medicine is part of the so called "third arrow" of Abenomics, which is aims to boost longer term growth through structural reform the first two arrows were monetary easing and fiscal consolidation.

As promised Abe did change the relevant laws in 2014 and the market has gradually come to see Japan as a world leader in regulating regenerative medicine.

But it lacks the early stage science of Australia, which is why it invited a local delegation to accompany the Trade Minister to Tokyo last week.

Now the question for Australia is whether it will allow its technologies to once again be licensed offshore and for Japan to receive much of the benefit or will take a bold step and follow Abe into the regenerative medicine revolution.

Link:
Japan's radical policy to fight ageing - The Australian Financial Review

medAge is customized medicine using a team approach to help patients become healthier and more energetic.

medAge patients lose fat and are leaner.They have lower risks for heart disease, cancer, arthritis, bone loss and other chronic conditions frequently associated with aging and the typical American lifestyle.

These are conditions that are commonly diagnosed and treated but rarely prevented in many medical offices. medAge is also anti-aging medicine staying abreast of the science to help patients stay healthy and look and feel young. medAge was founded in Asheville, a mecca for health and wellness centers. Due to its success at identifying and reversing early stages of disease,medAge can now be found in other parts of the country.

How medAge is different from other medical practices:

medAge is scientifically sound medicine and helps each individual patient formulate a healthy, sustainable way of living which is enjoyable and tailored to their specific lifestyle.

A division of medAge is dedicated to professional and amateur athletes of all ages. medAge for Athletes uses precise biometric measurements to test and train athletes allowing them to achieve peak performance in their individual sport. medAge trained athletes can be found all over the world competing and excelling in professional sports.

For more information on how to achieve optimal health visit http://www.medage.com.

Here is the original post:
Achieve a lifetime of good health with care at medAge - The Mountaineer

Whats going on in Eastgate Biotech Corp (OTCMKTS:ETBI) sharesis any ones guess, and any time you see a stock move 150% or more you must ask the question. I see (by looking at the technical picture in a chart below) that this is a stock that made a high volume low and turning out of triple sub penny status and are retracing losses from early April.

When a stock trades 65 million shares something is up. It goes back to the volume strategy all sub penny traders must adhere to in terms of the volume growth ramp driving prices higher. The presence of new money in the stock has been a consistent theme with many movers we write about. Be aware that you must pay attention when this volume begins to decline, because when the music stops (and it always does), shares can have unwanted downside volatility.

Eastgate Biotech Corp(OTCMKTS:ETBI) is an emerging pharmaceutical stock that produces and distributes innovative and healthy nutraceuticals based on natural therapies as well as focusing on new pharmaceutical developments. The driver revolves around its recent acquisition, OMNI Surgery and Anti-Aging Centre has appointed a new Medical Director.Dr. Ishaan Sundar has assumed the role of Medical Director effective immediately. Educated by the American Academy of Aesthetic Medicine, American Cosmetic Cellular Medicine Association, Laser Sheer Training Academy and trained in Injectable Placements, Dr. Sundar brings over 20 years of extensive practice to the OMNI state-of-the-art centre.With a distinguished career in Critical Care Medicine (ICU, CCU), Dr. Sundar will oversee medical and surgical operations at Saskatchewans only combined fee-for-service surgical and anti-aging centre.

OMNI Surgery and Anti-Aging Centre is an upscale facility serving an underserved market in Regina, Saskatchewan, Canada with great growth potential. It is poised to participate in the growing anti-aging market.According to Transparency Market Research, the Global Anti-Aging Market Boosted by Baby Boomer Population nearing retirement is to be worth US$191.7 Billion by 2019.

We are thrilled to welcome an experienced physician like Dr. Sundar to our leadership team.His holistic approach of crafting treatment plans unique to each individual mirrors OMNIs mission of making our patients feel comfortable and at ease, while getting the results that they want, states Bill Abajian, Global Business Development and Licensing at EastGate and former owner of OMNI Surgery.

Find outwhen $ETBI stock reaches critical levels. Subscribe to OracleDispatch.com Right Now by entering your Email in the box below.

OMNI is a fee-for-service, Surgery + Anti-Aging Centre offering plastic, orthopaedic, along with general surgical procedures. Alongside the surgical procedures, the Anti-Aging Centre is equipped with State-of-the-Art technology that work to contour, tone, and remove blemishes in order to reverse the aging process. As a Centre of Excellence in Saskatchewan, OMNIs board-certified surgeons work to deliver high quality care mindful of patients needs, while helping them achieve the results they want.

EastGate Biotech Corp. (OTCMKTS:ETBI) produces and distributes innovative and healthy nutraceuticals that are based on natural therapies and absorbed naturally by the body. But the real question here is about how shares will trade over the coming weeks and any retest of the lows on higher volume would be bad, on the upside you need to retrace the decline and test .03 cents which is another big leg higher for ETBIstock.

This would be easy to track by observing the volume alone, the short term players are here, now you need to sort out the meaning of these volume clues they translate to price so often it emerges as the most important metric to watch on any trading day.For more news on $ETBIand other fast-moving penny stocks, please subscribe to OracleDispatch.com below.

More:
What's Going On With Eastgate Biotech Corp (OTCMKTS:ETBI) - The Oracle Dispatch

Aspen Institute has added Umbilical cord blood STEM Cells to its treatment regimen focused on anti-aging and orthopedic regenerative medicine.

Dr. Gershon

ASPEN, CO, USA, April 25, 2017 /EINPresswire.com/ Aspen Institute for Anti-aging & Regenerative Medicine with offices in Aspen and Denver devote much of their time treating aging athletes with state of the art Bio-identical Hormone replacement and specially patients with pain or degenerative diseases. With over 35 years experience in Sports medicine the Aspen based practice utilizes cutting-edge technologies to help patients reduce pain and restore function with state of the art therapies like Stem cell therapy.

The Institute recently announced its latest breakthrough using Umbilical cord blood stem cells isolated in and FDA approved process from Bioburst technologies. These vibrant cells produce profound healing in arthritic joints and degenerative conditions such as those found in the knees, ankles, hips, shoulders and wrists. Most recently the Institute has been treating degenerative systemic diseases with great success such as Rheumatoid arthritis, Scleroderma, COPD or Emphysema and Diabetes. The Aspen clinic is the only practice in Colorado treating Erectile dysfunction with a unique combination of testosterone and stem cells. Where one simple injection can provide long-lasting benefits.

These remarkable treatments can repair tissue in the body that has been damaged from age related disease or degeneration. They do this by pinpointing the impaired areas, removing the swelling with powerful anti-inflammatory properties and healing them by regenerating new cells and tissue. The Institute also uses your bodies own stem cells derived from your own adipose tissue which is rich in regenerative stem cells. These cells are particularly effective in treating such conditions as degenerative arthritis, degenerative cartilage and ligaments, bursitis and tendonitis. According to Aspen Institute for Anti-aging & Regenerative Medicines founder Dr. Julian Gershon patients can experience a significant decrease in pain and an improvement in range of motion within weeks of one treatment. Our patients see results that are magical said Dr. Gershon. Its our hope that this truly amazing therapy will eliminate the need for drugs and painful surgery.

Dr.Gershon is stem cell Fellowship trained in Stem cell therapy. As well he is Triple Board certified by the American Osteopathic association in Sports Medicine and Family Medicine, and in Anti-aging Medicine by the American Academy of Anti-aging & Regenerative Medicine. Dr. Gershon in a physician peer to peer trainer for Bioburst and mentors physicians in regenerative medicine techniques from all over the world. Dr. Gershon has been performing cutting edge stem cell treatments for over 5 years in Texas and Colorado.

Dr. Rob Gershon Aspen Institute for Anti-aging & Regenerative Medicine 970-201-1332 email us here

Continued here:
Aspen Institute now offering regenerative STEM Cell therapy - MilTech

Researchers at Louisiana State University have determined that fish oil boosts damaged brain cells as well as damaged retinal cells. The study was spearheaded by Nicolas Bazan, the Director of LSU's Health New Orleans School of Medicine's Neuroscience Center of Excellence. The research was performed in a model of human retinal pigment epithelial cells and ischemic stroke.

About NPD1

NPD1 is an acronym that stands for neuroprotectin D1. This is a lipid messenger made from omega-3 fatty acid docosahexaenoic acid or DHA. It is made in an on-demand fashion when cell survival is threatened. NPD1 was identified and named back in 2004 by Dr. Bazan. Oxidative stress is created by the steady production of harmful free radicals. It sets the stage for cell death. Such death is hastened by catastrophic happenings like blinding-eye diseases, neurodegenerative diseases, and ischemic stroke.

The Findings

This study is considered a breakthrough as it provides the first evidence that NDP1, a signaling molecule, prompts the creation of a protective protein against harmful free radicals as well as brain cell and retinal cell injury. Dr. Bazan's research team found that the systematic administering of NPD1 a single hour following two hours of experimental stroke boosted the creation and accessibility of ring finger protein 146 called Iduna. Iduna allows for rapid DNA repair and protection against programmed cell death that occurs in stroke known as "parthanatos". This occurs as Iduna reduces the generation of PARP, a harmful protein.

The research team's findings also show that NDP1 boosted the generation of Iduna and protection in two distinct types of RPE cells, primary RPE and ARPE-19, that were enduring uncompensated oxidative stress. It was determined the effect of NDP1 on Iduna activity peaked about six hours following the beginning of oxidative stress. A dose-dependent curve displayed heightened Iduna activity commencing s 25 nM NPD1 in each type of RPE cells. The results indicate NDP1 causes Iduna activity in a selective manner in instances when uncompensated oxidative stress stimulates the creation of NPD1 that consequently triggers Iduna.

The findings are important as they show that NPD1 created in an on-demand manner, modulates the amount of Iduna protein necessary for cell survival. Iduna is important for the reprogramming of cell existence and proper functionality. A continued study of this protein might soon lead to key developments in terms of therapeutic interventions for ischemic stroke and retinal degeneration.

Ludmila Belayev, Pranab K Mukherjee, Veronica Balaszczuk, Jorgelina M Calandria, Andre Obenaus, Larissa Khoutorova, Sung-Ha Hong, Nicolas G Bazan. Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke. Cell Death and Differentiation, 2017; DOI: 10.1038/cdd.2017.55

Read the original:
Fish Oil Component Boosts Damaged Brain, Retinal Cells - Anti Aging News

Photo: Stocksy/Lauren Naefe

1/3

Among yourwellness-savvy friends, you may have noticed that the wordinflammationcomes upa lot. Its linked to everything from acne to allergies to Alzheimersand now anti-inflammatory products areeverywhere, from the grocery store to the beauty counter. But, if you can believe it, there was a time when you got seriousblowback (and even ridicule) for linking the phenomenonwith disease and agingjust askNicholas Perricone, MD.

Nearly two decades beforehealthy tastemakersstarted using the term as frequently as they Google turmeric face masks, heput the topic on the (medical) map with his 2000 bookThe Wrinkle Cure.

During medical school and my three-year residency in dermatology, I made important connections between inflammation and disease, says Dr. Perricone (who you may recognizefrom his his eponymous skin-care line, which recently expanded its line of supplementsmany of which are anti-inflammatory, natch). To learn about hundreds of skin diseases we studied in books, we also needed to recognize them in clinical examination and under a microscope.

Inflammation has an unmistakable appearancehe describes them as dark blue dots, like confetti, although the presence of inflammation is nothing to celebrate. Quite the opposite. And that led to his discovery ofgroundbreaking intel thats still beingdissectedtoday.

2/3

Dr. Perricone quickly saw that inflammation wasnt only presentin skin diseasesthe same thing was showing up when he looked at aging skin, toowhich led him to question whether inflammation itself was causing these changes.

I began to consider wrinkles as a disease, since inflammation was present when damage to skin tissue resulted in wrinkles, he says. My professors insisted the inflammation was just part of the picture; a byproduct and not the cause.

Every disease I studied had a common theme: Whether it was cancer or aging, inflammation was present.

He kept looking further into these not-so-good particles, and found it to be tied to everything from arthritis to heart disease. Every disease I studied had a common theme: Whether it was cancer or aging, inflammation was present.

Dr. Perricone remained adamant that inflammation wasnt merely a secondary response, as everyone else was telling him. I believed inflammation to be the key to the whole process of disease of every type, he says.It may sound absurd now, but histheory was mostly dismissed. Since he published his book, however, other researchers have fallen in line, and today he notes that there have been tremendous strides in the field of anti-aging medicine. Now its accepted by mainstream science, which recognizes its validity and its serious threat to beauty, health, and longevity, he says.

3/3

As the wellnessworldnow knows, the conditionrears its proverbial head in a number of ways (all of which are pretty much unwelcome).

And to bust an all-too-common myth about the i-word: Just because you cant see it doesntmean its not there doing itsdamage, according to Dr. Perricone. Inflammation exists in a broad spectrum that ranges from low to high, he explains. On the low side, it occurs on a cellular and even a molecular level, invisible to the naked eye and possibly eveninvisible under the microscope. This inflammation is highly damaging to all organs including the skin. On the high side, the inflammation is visibly evident as redness and swelling such as seen in a wound or sunburn.

Just because you cant see inflammationdoesntmean its not there doing itsdamage.

So what in your everyday life could be causing this?

Sugar and starchy foods. Dr. Perricone notes that theytend to lead to skin damage. Foods and beverages that are rapidly converted to sugar are also pro-inflammatory, he says. That means soda, all kinds of sugar, pasta, bread, anything friedthe list goes on.

Processed foods and anything with trans fats.Not a surprise hereand there are lots of reasons to avoid the chips-and-dips aisle.Also be sure to avoid processed foods and foods containing unhealthy trans fats.

Stress. This is a big one,along with environmental stressors (and the hidden allergies they could be triggering), a weakened immune system, too much exposure to ultraviolet light, and hormonal changes.

Glycemic spikes.The single biggest thing you can do control inflammation, according to Dr. Perricone?Watch your blood sugar and insulin levels by followingan anti-inflammatory diet, hesays. To do so, youmust avoid foods that provoke a glycemic response in the body, which is a rapid rise in blood sugar, he says. This is the key to health, longevity, mental clarity, well-being, and beautiful, youthful skin.

In other words: It might betime to finally cut sugar after all.

To help out with your eating plan, this is what the ultimate anti-inflammatory meal looks like. For a delicious recipe, this turmeric fried rice is a major upgrade from takeout.

Read the original here:
The 4 skin-sabotaging triggers you should avoid, according to the OG of inflammation research - Well+Good

Fort Lauderdale, FL Life Extension has partnered with Insilico Medicine to introduce Ageless Cell, the first supplement in its GEROPROTECT line to promote healthy aging by inhibiting cellular senescence.

Cellular senescence is a natural part of the aging process where cells no longer function optimally, affecting organ function, cellular metabolism, and inflammatory response. The accumulation of these senescent cells contributes to the process of aging. The Ageless Cell supplements inhibit the effects of cellular senescence by acting as geroprotectors, or interventions aimed to increase longevity and impede the onset of age-related diseases by targeting and inhibiting senescence-inducing pathways and inhibiting the development of senescent cells.

The partnership with Insilico Medicine allowed researchers to use deep learning algorithms to comb through hundreds of studies and thousands of data points a process that could have taken decades to identify four key anti-aging nutrients: N-Acetyl-L-Cysteine (NAC), myricetin, gamma-tocotrienol, and EGCG. These compounds target pathways that are known to contribute to or protect against the development of senescent cells.

Specifically, NAC upregulates signaling pathways that protect cells against oxidative stress, which promotes cellular senescence. It also reduces pathways that promote inflammation. Myricetin regulates a family of stress-responsive signaling molecules known to regulate aging in many tissues. It also promotes cell differentiation and self-repair. Gamma tocotrienol modulates the mevalonate pathway that controls cholesterol production, cancer promotion, and bone formation. And EGCG regulates the Wnt pathway that determines the fate of developing cells and also prevents sugar-induced damage to tissues, helping to suppress their pro-aging effects.

Clinical aging studies are extremely difficult, if not impossible, to perform at this time. Our collaboration with Insilico Medicine has allowed us to develop geroprotective formulations by using artificial intelligence to study very large data sets, said Andrew G. Swick, Ph.D., senior vice president of product development and scientific affairs for Life Extension.

Scientists found these four nutrients have various complementary and reinforcing properties to influence key anti-aging pathways and combat aging factors by modulating specific biological pathways. By rejuvenating near-senescent cells and encouraging the bodys healthy process for dealing with senescent cells, Ageless Cell turns back the clock at the cellular level, said Michael A. Smith, M.D., senior health scientist for Life Extension. Alex Zhavoronkov, Ph.D., CEO of Insilico Medicine said, Together, these four natural compounds represent the beginning of the future anti-aging cocktails identified using artificial intelligence under expert human supervision.

The rest is here:
Life Extension and Insilico Medicine Use AI to Develop Ageless Cell - WholeFoods Magazine

Question: Are there any new technologies for fat reduction?

Answer: It is interesting to watch technology as it continues to evolve. Many of my patients are up to date with what is trending in aesthetic technology. There is a new exciting technology that melts and tightens skin simultaneous without downtime. Coolsculpting has been a good fat reduction treatment for many of my patients. It is a way to noninvasively destroy fat cells by freezing fat. However it takes about one hour per area and, depending on the patient, could take up to four or six hours in a day! Also, the cost of Coolsculpting is pretty much equivalent to liposuction.

A newer technology has just been FDA-approved for the same application of destroying fat cells non-invasively, but it uses heat. Its called SculpSure by Cynosure. SculpSure is a laser device that uses the same wavelength as Smart Lipo.

It targets fat cells and destroys them without any incisions. Unlike Coolsculpting, Sculpsure takes less time, the treatment areas are much larger and there is no downtime. One treatment takes only 25 minutes and there have been no reported side effects.

The treatments applicators are placed on the skin and a balance of laser wavelength with cold is projected to the fat layer, making it hot enough to achieve the right temperatures to destroy fat cells, but cold enough to be comfortable. The destroyed cells are disposed of by the bodys lymphatic system.

The results are seen in six to eight weeks and most people require just one treatment. Another game-changing advantage: The laser tightens skin. So in summary, Sculpsure is less expensive, takes less time and tightens skin very effectively.

Daniela Dadurian, M.D., specializes in anti-aging medicine and is an expert in non-surgical body-contouring techniques. She received her medical degree from the University of Miami School of Medicine and has traveled the world researching the safest and latest technologies on the market.

________________________________________

MD Beauty Labs Medical Spa and Wellness Center

320 S. Quadrille Blvd., West Palm Beach

Read the original post:
Sculpsure is new for fat reduction - Palm Beach Post

Alvin Pettle, MD, FRCS(C), Anti-Aging Doctor and Bio-Identical Hormone Specialist with the support of his beautiful wife, Carol, RN at the Ruth Pettle Wellness Centre, has been named a 2017 Top Doctor in Toronto, Ontario, Canada. Top Doctor Awards is dedicated to selecting and honoring those healthcare practitioners who have demonstrated clinical excellence while delivering the highest standards of patient care.

Dr. Alvin Pettle is a vastly experienced physician, having been in practice for more than four decades. His long and successful career in medicine began in 1969, when he graduated from the University of Toronto School of Medicine in Ontario. He later completed fellowships in Obstetrics and Gynecology. Dr. Pettle believes in continual learning and education, and he has completed many advanced training courses in subjects including natural medicine, advanced colposcopy, and advanced hysteroscopy.

Dr. Pettle served for many years as Chief of Obstetrics and Gynecology at Torontos Etobicoke General Hospital, but he is now renowned as one of Canadas top anti-aging doctors and bio-identical hormone experts. With the support of his expert team, he uses the latest technology and techniques in hormone replacement therapy to tackle the problems associated with aging and menopause.

Dr. Pettle has earned the coveted title of Fellow of the Royal College of Surgeons of Canada, and he is also a member of many professional organizations including the American College of Infertility, the Canadian Medical Association, Physicians for Peace, and the Society of Obstetrics and Gynecology of Canada. He is the author of numerous books and medical papers, and often appears on television to talk about bio-identical hormone therapy. His expertise in this field makes Dr. Alvin Pettle a very worthy winner of a 2017 Top Doctor Award.

About Top Doctor Awards

Top Doctor Awards specializes in recognizing and commemorating the achievements of todays most influential and respected doctors in medicine. Our selection process considers education, research contributions, patient reviews, and other quality measures to identify top doctors.

Follow this link:
Expert Anti-Aging Doctor and Bio-Identical Hormone Specialist, Alvin Pettle, MD, FRCS(C), is to be Recognized as a ... - PR NewsChannel (press...