Low T Center – Men’s Health Clinic – Testosterone Replacement

Men's Clinic - What's Offered?

With little to no energy, you just cant function at times, and you certainly dont want to eat right or exercise. The lethargy could be caused by any number of health conditions such as obstructive sleep apnea, low testosterone levels, severe allergies, or even low thyroid.When men suffer from any of these conditions, poor lifestyle choices are made, especially when it comes to diet and exercise which can lead to more serious health problems down the road such as hypertension, high cholesterol, and diabetes. Lets gain control of your health issues before the conditions worsen.

The good news is you dont have to feel sluggish. Our mens health clinic staff at the Low T Center nearest you can quickly and easily determine what type of help is needed. We listen and learn about you, your symptoms, and your health goals. The combination of that knowledge along with a thorough analysis of your lab results will be used to prescribe a healthcare plan tailored to you.

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Low T Center - Men's Health Clinic - Testosterone Replacement

5 Best Testosterone Supplements For Men Over 50

Testosterone supplements are far and away the most popular type of supplement in the industry as of late. Many of them are clinically tested and proven to be effective.

The problem is that there are hundreds of testosterone boosters out there, and most guys have a hard time weeding through the duds to get to that miracle supplement. If you don't choose the right one, you could end up wasting your money and experiencing unwanted side effects.

In addition, there are several testosterone boosters out there that are designed for younger men who are looking to use testosterone boosting as a bodybuilding aid.

Men over the age of 50 should avoid supplements that are directed towards younger bodybuilders because they often do not contain the ingredients that are most beneficial to aging men.

We have done the research and weeded out the duds and the supplements that are strictly designed for bodybuilders, and discovered the 5 best testosterone supplements for men over 50.

The biggest reason testosterone supplements are so widely used today is because almost all men end up suffering from low testosterone levels at some point in their lives.

Generally, testosterone levels tend to gradually decrease when men reach their thirties. This decline in testosterone tends to get progressively worse over time, causing some serious problems.

Symptoms of Low Testosterone (Low T) include

If you suffer from one or more of these symptoms, you more than likely have Low Testosterone to some extent and could benefit significantly from an effective testosterone supplement.

Men over 50 are the most likely to suffer from these issues. The main reason men seek natural testosterone supplements, is because they want to avoid testosterone replacement therapy.

Hormone replacement therapy generally costs several hundreds of dollars per month and can actually pose some detriments to ones health. It is an unnatural way to go about correcting the problem.

Testosterone supplementation is an all-natural, risk-free, inexpensive, and usually effective way to correct the symptoms of Low T.

TestoTEK is in our opinion, the best testosterone boosting supplement on the market. And while it is very close to the other well-respected products in the top 5, it beats them out for a number of reasons.

Every test0-booster supplement is a little unique but there are a handful of ingredients that should be in every booster. And they should be represented in high potencies so that they have a genuine impact on the body. Some companies merely want the ingredient listed on the label and include them in such low potencies that they have minimal results.

TestoTEK has all the core ingredients and they are in big-time potencies. D aspartic acid, vitamin D3 and zinc are probably the most important testosterone ingredients in existence. Much clinical research has shown these to be unquestionably the most important. TestoTEK has as much or more of these three ingredients than any other supplement we have reviewed.

Furthermore, TestoTEKis tied with Prime Malewith the most ingredients in their formula, twelve, and these cover a broad spectrum of mens health. And lastly, TestoTEKcosts less than both Prime Male and TestoFuel and with their coupon code, is also less expensive than Testogen.

The product has no real weakness it is more potent, has more ingredients and is less money than the other top 5.

Testogen is anastoundingly effective testosterone booster that strives to make improvements in multiple areas in which men with low testosterone struggle. The manufacturer refers to the product as a testosterone triple action formula, and it truly is.

Strengthen, stimulate, sharpen. Those are the goals as stated on the bottle, referring to increased muscle production, stimulation of boosted testosterone levels, and improved performance both in the gym and in bed.

The ingredients back the claims of the manufacturer with clinical studies, significant potencies and the absence of the dreaded proprietary blend so you know how much of each ingredient you are ingesting.

The nutrition label tells you everything you need to know. It was a difficult decision to rank this product #1 because it is so close to Prime Male and TestoFuel, andis a huge accomplishment considering how competitive the testosterone supplement industry is.

The primary reason this product is so popular is because of the whopping 2,000 milligrams of D-aspartic acid. D-aspartic acid is perhaps the most popular testosterone-boosting ingredient (or at least in the top 3) and can be found in the vast majority of effective testosterone supplements.

However, it is usually found in much smaller amounts. A standard amount is about 1,000 milligrams, but you will see that the top 5 all contain about 1,500 milligrams or more. (Monster T contains 3,500 milligrams per serving but is missing other ingredients.)Testogen contains the highest amount of D-aspartic acid that we have seen except for Monster T.

A huge amount of D-aspartic acid isnt the only thing keeping this supplement ranked elite. Testogen has much more to offer, including proven ingredients such as tribulus terrestris, ginseng extract, zinc, and more. To learn more about what each individual ingredient does and how they work to boost your testosterone levels, be sure to check out the full review.

Click Here to Read the Full Testogen Review

Prime Male is a highly effective testosterone supplement that is designed specifically for aging men. It is a carefully formulated supplement youve been looking for that can catapult your libido into overdrive, improve bedroom performance, spike energy levels to where they were in your 20s, harden your body with quality muscle mass, melt unnecessary body fat, and more. The high quality scientifically backed ingredients are the secret to this powerful testosterone booster.

Before you buy a testosterone booster, or any supplement, you want to make sure the ingredients are clinically proven. When you do, you reduce the risk of purchasing a worthless, ineffective product.

The clinical studies often include any side effects reported. The key is to find the ingredients that are backed by science and have no major side effects reported.

Prime Male is one of our bestchoices for men over 50 because it contains exactly this type of ingredients. Each ingredient is linked to several clinical studies for their ability to naturally, effectively and safely boost the bodys testosterone production.

You also want to make sure that theres enough of the ingredient in the product. Though difficult, try and avoid proprietary blends whenever you can. A proprietary blend is essentially a blend of ingredients of which the amounts are undisclosed.

You are able to see what ingredients the blend contains but not the amount of each ingredient. Manufacturers claim that they use a proprietary blend in order to protect their formulas, but really they use it so they can include small amounts of key ingredients in order to save money.

Prime Male uses no proprietary blend format on their label. In fact, it contains just less than 3,000 milligrams of overall nutrition per serving. That is an astounding amount of nutrients for one supplement to contain, and the individual amounts of each ingredient are disclosed on the label.

When choosing a testosterone booster supplement, last but not least, determine if the ingredients are synergistic with each other? In order for a product to do its job, the ingredients must be able to work well together. (And if you dont want to do this type of research, thats what were here for.)

The ingredients of this supplement were carefully chosen based on their synergistic properties.

All of these facts are part of what makes this the #2testosterone supplement on the market, but one final piece is what ranks this supplement among the best testosterone supplements for men over 50 specifically.

The finishing touch is the inclusion of 300 milligrams of mucana pruriens. This ingredient is vitally important to men over 50 because of its ability to boost libido.

Mucana pruriens is an ingredient that you wont find in many supplements designed for younger bodybuilders because its not necessarily beneficial to them, but it plays a very special role for aging men with Low T.

Learn More:

American Testosterone Clinics of the United States: https://www.testosterone.me

Longevity – Wikipedia

The word "longevity" is sometimes used as a synonym for "life expectancy" in demography. However, the term longevity is sometimes meant to refer only to especially long-lived members of a population, whereas life expectancy is always defined statistically as the average number of years remaining at a given age. For example, a population's life expectancy at birth is the same as the average age at death for all people born in the same year (in the case of cohorts). Longevity is best thought of as a term for general audiences meaning 'typical length of life' and specific statistical definitions should be clarified when necessary.

Reflections on longevity have usually gone beyond acknowledging the brevity of human life and have included thinking about methods to extend life. Longevity has been a topic not only for the scientific community but also for writers of travel, science fiction, and utopian novels.

There are many difficulties in authenticating the longest human life span ever by modern verification standards, owing to inaccurate or incomplete birth statistics. Fiction, legend, and folklore have proposed or claimed life spans in the past or future vastly longer than those verified by modern standards, and longevity narratives and unverified longevity claims frequently speak of their existence in the present.

A life annuity is a form of longevity insurance.

Various factors contribute to an individual's longevity. Significant factors in life expectancy include gender, genetics, access to health care, hygiene, diet and nutrition, exercise, lifestyle, and crime rates. Below is a list of life expectancies in different types of countries:[3]

Population longevities are increasing as life expectancies around the world grow:[1][4]

The Gerontology Research Group validates current longevity records by modern standards, and maintains a list of supercentenarians; many other unvalidated longevity claims exist. Record-holding individuals include:[5][6][7]

Evidence-based studies indicate that longevity is based on two major factors, genetics and lifestyle choices.[9]

Twin studies have estimated that approximately 20-30% the variation in human lifespan can be related to genetics, with the rest due to individual behaviors and environmental factors which can be modified.[10] Although over 200 gene variants have been associated with longevity according to a US-Belgian-UK research database of human genetic variants,[11] these explain only a small fraction of the heritability.[12] A 2012 study found that even modest amounts of leisure time physical exercise can extend life expectancy by as much as 4.5 years.[13]

Lymphoblastoid cell lines established from blood samples of centenarians have significantly higher activity of the DNA repair protein PARP (Poly ADP ribose polymerase) than cell lines from younger (20 to 70 year old) individuals.[14] The lymphocytic cells of centenarians have characteristics typical of cells from young people, both in their capability of priming the mechanism of repair after H2O2 sublethal oxidative DNA damage and in their PARP gene expression.[15] These findings suggest that elevated PARP gene expression contributes to the longevity of centenarians, consistent with the DNA damage theory of aging.[16]

In preindustrial times, deaths at young and middle age were more common than they are today. This is not due to genetics, but because of environmental factors such as disease, accidents, and malnutrition, especially since the former were not generally treatable with pre-20th-century medicine. Deaths from childbirth were common for women, and many children did not live past infancy. In addition, most people who did attain old age were likely to die quickly from the above-mentioned untreatable health problems. Despite this, there are many examples of pre-20th-century individuals attaining lifespans of 85 years or greater, including Benjamin Franklin, Thomas Jefferson, John Adams, Cato the Elder, Thomas Hobbes, Eric of Pomerania, Christopher Polhem, and Michelangelo. This was also true for poorer people like peasants or laborers. Genealogists will almost certainly find ancestors living to their 70s, 80s and even 90s several hundred years ago.

For example, an 1871 census in the UK (the first of its kind, but personal data from other censuses dates back to 1841 and numerical data back to 1801) found the average male life expectancy as being 44, but if infant mortality is subtracted, males who lived to adulthood averaged 75 years. The present life expectancy in the UK is 77 years for males and 81 for females, while the United States averages 74 for males and 80 for females.

Studies have shown that black American males have the shortest lifespans of any group of people in the US, averaging only 69 years (Asian-American females average the longest).[17] This reflects overall poorer health and greater prevalence of heart disease, obesity, diabetes, and cancer among black American men.

Women normally outlive men. Theories for this include smaller bodies (and thus less stress on the heart), a stronger immune system (since testosterone acts as an immunosuppressant), and less tendency to engage in physically dangerous activities.

There is debate as to whether the pursuit of longevity is a worthwhile health care goal. Bioethicist Ezekiel Emanuel, who is also one of the architects of ObamaCare, has argued that the pursuit of longevity via the compression of morbidity explanation is a "fantasy" and that longevity past age 75 should not be considered an end in itself.[18] This has been challenged by neurosurgeon Miguel Faria, who states that life can be worthwhile in healthy old age, that the compression of morbidity is a real phenomenon, and that longevity should be pursued in association with quality of life.[19] Faria has discussed how longevity in association with leading healthy lifestyles can lead to the postponement of senescence as well as happiness and wisdom in old age.[20]

All of the biological organisms have a limited longevity, and different species of animals and plants have different potentials of longevity. Misrepair-accumulation aging theory [21][22] suggests that the potential of longevity of an organism is related to its structural complexity.[23] Limited longevity is due to the limited structural complexity of the organism. If a species of organisms has too high structural complexity, most of its individuals would die before the reproduction age, and the species could not survive. This theory suggests that limited structural complexity and limited longevity are essential for the survival of a species.

Longevity myths are traditions about long-lived people (generally supercentenarians), either as individuals or groups of people, and practices that have been believed to confer longevity, but for which scientific evidence does not support the ages claimed or the reasons for the claims.[24][25] A comparison and contrast of "longevity in antiquity" (such as the Sumerian King List, the genealogies of Genesis, and the Persian Shahnameh) with "longevity in historical times" (common-era cases through twentieth-century news reports) is elaborated in detail in Lucian Boia's 2004 book Forever Young: A Cultural History of Longevity from Antiquity to the Present and other sources.[26]

After the death of Juan Ponce de Len, Gonzalo Fernndez de Oviedo y Valds wrote in Historia General y Natural de las Indias (1535) that Ponce de Len was looking for the waters of Bimini to cure his aging.[27] Traditions that have been believed to confer greater human longevity also include alchemy,[28] such as that attributed to Nicolas Flamel. In the modern era, the Okinawa diet has some reputation of linkage to exceptionally high ages.[29]

Longevity claims may be subcategorized into four groups: "In late life, very old people often tend to advance their ages at the rate of about 17 years per decade .... Several celebrated super-centenarians (over 110 years) are believed to have been double lives (father and son, relations with the same names or successive bearers of a title) .... A number of instances have been commercially sponsored, while a fourth category of recent claims are those made for political ends ...."[30] The estimate of 17 years per decade was corroborated by the 1901 and 1911 British censuses.[30] Time magazine considered that, by the Soviet Union, longevity had been elevated to a state-supported "Methuselah cult".[31] Robert Ripley regularly reported supercentenarian claims in Ripley's Believe It or Not!, usually citing his own reputation as a fact-checker to claim reliability.[32]

The U.S. Census Bureau view on the future of longevity is that life expectancy in the United States will be in the mid-80s by 2050 (up from 77.85 in 2006) and will top out eventually in the low 90s, barring major scientific advances that can change the rate of human aging itself, as opposed to merely treating the effects of aging as is done today. The Census Bureau also predicted that the United States would have 5.3 million people aged over 100 in 2100. The United Nations has also made projections far out into the future, up to 2300, at which point it projects that life expectancies in most developed countries will be between 100 and 106 years and still rising, though more and more slowly than before. These projections also suggest that life expectancies in poor countries will still be less than those in rich countries in 2300, in some cases by as much as 20 years. The UN itself mentioned that gaps in life expectancy so far in the future may well not exist, especially since the exchange of technology between rich and poor countries and the industrialization and development of poor countries may cause their life expectancies to converge fully with those of rich countries long before that point, similarly to the way life expectancies between rich and poor countries have already been converging over the last 60 years as better medicine, technology, and living conditions became accessible to many people in poor countries. The UN has warned that these projections are uncertain, and cautions that any change or advancement in medical technology could invalidate such projections.[33]

Recent increases in the rates of lifestyle diseases, such as obesity, diabetes, hypertension, and heart disease, may eventually slow or reverse this trend toward increasing life expectancy in the developed world, but have not yet done so. The average age of the US population is getting higher[34] and these diseases show up in older people.[35]

Jennifer Couzin-Frankel examined how much mortality from various causes would have to drop in order to boost life expectancy and concluded that most of the past increases in life expectancy occurred because of improved survival rates for young people. She states that it seems unlikely that life expectancy at birth will ever exceed 85 years.[36] Michio Kaku argues that genetic engineering, nanotechnology and future breakthroughs will accelerate the rate of life expectancy increase indefinitely.[37] Already genetic engineering has allowed the life expectancy of certain primates to be doubled, and for human skin cells in labs to divide and live indefinitely without becoming cancerous.[38]

Reliable data from 1840 through 2002 indicates life expectancy has risen linearly for men and women, albeit more slowly for men. For women the increase has been almost three months per year, for men almost 2.7 months per year. In light of steady increase, without any sign of limitation, the suggestion that life expectancy will top out must be treated with caution. Scientists Oeppen and Vaupel observe that experts who assert that "life expectancy is approaching a ceiling ... have repeatedly been proven wrong." It is thought that life expectancy for women has increased more dramatically owing to the considerable advances in medicine related to childbirth.[39]

Currently living:

Non-living:

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Longevity - Wikipedia

Offer Ends Soon Ready Version – The Human Longevity Project

The Human Longevity Project is a 9-Part documentary with over 100 interviews from the worlds leading doctors, researchers, scientists, health experts, and healers.

We combine the most cutting-edge science with a deep investigation into the worlds healthiest and oldest populations.

This program gives you a detailed roadmap and step-by-step action plan for you to live your longest, happiest, and healthiest life.

Included are detailed interviews with the worlds healthiest and longest-lived people, a large number of whom are happy centenarians, tapping into powerful ancient wisdom for optimal health, wellbeing and maximum longevity!

Whether you or your loved ones have a chronic illness like depression, autoimmune disease, digestive issues

Or maybe its Diabetes, Heart Disease, Autism or Alzheimer's

Never before have so many doctors, researchers, scientists, health experts, and the healthiest populations on Earth come together to create this educational masterpiece, showing you solutions that can be implemented to avoid pain and disease in your life, and start accessing the SECRET, MODERN and ANCIENT remedies for You and Your familys Optimal Healing and Lifespan.

Dont delay get your personal copy today. Once The Human Longevity Project premiere is overyou'll never see this offer again! Prices will more than DOUBLE at the end of the premiere!

REMEMBER This offer is only available here during The Human Longevity Project World Premiere! Once this series is over, this offer will be gone FOR GOOD.

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Offer Ends Soon Ready Version - The Human Longevity Project

Human Longevity – Wikipedia

Human Longevity is a San Diego-based venture launched by Craig Venter and Peter Diamandis in 2013. Its goal is to build the world's most comprehensive database on human genotypes and phenotypes, and then subject it to machine learning so that it can help develop new ways to fight diseases associated with aging.[1] The company received US$80 million in investments in its Series A offering in summer 2014 and announced a further $220 million Series B investment offering in April 2016.[2] It has made deals with drug companies Celgene and AstraZeneca to collaborate in its research.

While it is conducting research, the company is offering a wellness service known as "Health Nucleus," which offers customers a range of medical tests such as a full genome sequencing and tests for early indications of cancers, Alzheimer's and heart disease.[3] This testing is meant to help people catch diseases earlier than otherwise possible and to identify risk factors for diseases later in life.[4]

At the start of 2017 the company hired Cynthia Collins from GE Healthcare, and Venter became Executive Chair. The company's chief operating office, Mark Winham, left the company in mid-2017, and Collins and the company's chief medical officer, Brad Perkins, left in December. Venter stepped back into the CEO role, but announced in May 2018 that he was leaving the company to return to the J. Craig Venter Institute.[5] Venter was sued for allegedly 'stealing trade secrets' at Human Longevity.[6] The case has been dismissed.[7]

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Human Longevity - Wikipedia

Healthy Lifestyle: Medical Information, Symptoms, & Taboo …

Youve probably heard of the old Chinese curse that Bobby Kennedy spoke about in a speech May you live in interesting times. And right now is a very interesting time, especially when it comes to our nations health. Consider that:

Now something else you should know about that old Chinese curse its fake news. Theres no known record of the phrase in history. Ah, fake news. Thats a term that warrants its own discussion, but we digress.

Misinformation is a serious problem when it comes to health and lifestyle advice. But a specific side is what you wont see us pushing on this website. Healthy Lifestyle is non-partisan, and in our stories we work to include all points of view and present all sides of the important issues, no matter how taboo or silly. We want our readers to see various sides of opinions and not just one side.

We want to hear your stories too!

The best online communities thrive on the input of their members. We care about real stories that show the everyday realities and choices Americans make about their healthcare. If you have a story to tell, wed love to hear it visit http://www.HealthyLifestyle.org/story/.

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Healthy Lifestyle: Medical Information, Symptoms, & Taboo ...

Becoming a vegetarian – Harvard Health

People become vegetarians for many reasons, including health, religious convictions, concerns about animal welfare or the use of antibiotics and hormones in livestock, or a desire to eat in a way that avoids excessive use of environmental resources. Some people follow a largely vegetarian diet because they can't afford to eat meat. Becoming a vegetarian has become more appealing and accessible, thanks to the year-round availability of fresh produce, more vegetarian dining options, and the growing culinary influence of cultures with largely plant-based diets.

Approximately six to eight million adults in the United States eat no meat, fish, or poultry, according to a Harris Interactive poll commissioned by the Vegetarian Resource Group, a nonprofit organization that disseminates information about vegetarianism. Several million more have eliminated red meat but still eat chicken or fish. About two million have become vegans, forgoing not only animal flesh but also animal-based products such as milk, cheese, eggs, and gelatin.

Traditionally, research into vegetarianism focused mainly on potential nutritional deficiencies, but in recent years, the pendulum has swung the other way, and studies are confirming the health benefits of meat-free eating. Nowadays, plant-based eating is recognized as not only nutritionally sufficient but also as a way to reduce the risk for many chronic illnesses. According to the American Dietetic Association, "appropriately planned vegetarian diets, including total vegetarian or vegan diets, are healthful, nutritionally adequate, and may provide health benefits in the prevention and treatment of certain diseases."

"Appropriately planned" is the operative term. Unless you follow recommended guidelines on nutrition, fat consumption, and weight control, becoming a vegetarian won't necessarily be good for you. A diet of soda, cheese pizza, and candy, after all, is technically "vegetarian." For health, it's important to make sure that you eat a wide variety of fruits, vegetables, and whole grains. It's also vital to replace saturated and trans fats with good fats, such as those found in nuts, olive oil, and canola oil. And always keep in mind that if you eat too many calories, even from nutritious, low-fat, plant-based foods, you'll gain weight. So it's also important to practice portion control, read food labels, and engage in regular physical activity.

You can get many of the health benefits of being vegetarian without going all the way. For example, a Mediterranean eating pattern known to be associated with longer life and reduced risk of several chronic illnesses features an emphasis on plant foods with a sparing use of meat. Even if you don't want to become a complete vegetarian, you can steer your diet in that direction with a few simple substitutions, such as plant-based sources of protein beans or tofu, for example or fish instead of meat a couple of times a week.

Only you can decide whether a vegetarian diet is right for you. If better health is your goal, here are some things to consider.

Strictly speaking, vegetarians are people who don't eat meat, poultry, or seafood. But people with many different dietary patterns call themselves vegetarians, including the following:

Vegans (total vegetarians): Do not eat meat, poultry, fish, or any products derived from animals, including eggs, dairy products, and gelatin.

Lacto-ovo vegetarians: Do not eat meat, poultry, or fish, but do eat eggs and dairy products.

Lacto vegetarians: Eat no meat, poultry, fish, or eggs, but do consume dairy products.

Ovo vegetarians: Eat no meat, poultry, fish, or dairy products, but do eat eggs.

Partial vegetarians: Avoid meat but may eat fish (pesco-vegetarian, pescatarian) or poultry (pollo-vegetarian).

Maybe. Compared with meat eaters, vegetarians tend to consume less saturated fat and cholesterol and more vitamins C and E, dietary fiber, folic acid, potassium, magnesium, and phytochemicals (plant chemicals), such as carotenoids and flavonoids. As a result, they're likely to have lower total and LDL (bad) cholesterol, lower blood pressure, and lower body mass index (BMI), all of which are associated with longevity and a reduced risk for many chronic diseases.

But there still aren't enough data to say exactly how a vegetarian diet influences long-term health. It's difficult to tease out the influence of vegetarianism from other practices that vegetarians are more likely to follow, such as not smoking, not drinking excessively, and getting adequate exercise. But here's what some of the research has shown so far:

Heart disease. There's some evidence that vegetarians have a lower risk for cardiac events (such as a heart attack) and death from cardiac causes. In one of the largest studies a combined analysis of data from five prospective studies involving more than 76,000 participants published several years ago vegetarians were, on average, 25% less likely to die of heart disease. This result confirmed earlier findings from studies comparing vegetarian and nonvegetarian Seventh-day Adventists (members of this religious group avoid caffeine and don't drink or smoke; about 40% are vegetarians). In another study involving 65,000 people in the Oxford cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford), researchers found a 19% lower risk of death from heart disease among vegetarians. However, there were few deaths in either group, so the observed differences may have been due to chance.

For heart protection, it's best to choose high-fiber whole grains and legumes, which are digested slowly and have a low glycemic index that is, they help keep blood sugar levels steady. Soluble fiber also helps reduce cholesterol levels. Refined carbohydrates and starches like potatoes, white rice, and white-flour products cause a rapid rise in blood sugar, which increases the risk of heart attack and diabetes (a risk factor for heart disease).

Nuts are also heart-protective. They have a low glycemic index and contain many antioxidants, vegetable protein, fiber, minerals, and healthy fatty acids. The downside: nuts pack a lot of calories, so restrict your daily intake to a small handful (about an ounce). The upside: because of their fat content, even a small amount of nuts can satisfy the appetite.

Walnuts, in particular, are a rich source of omega-3 fatty acids, which have many health benefits. Even so, fish are the best source of omega-3s, and it's not clear whether plant-derived omega-3s are an adequate substitute for fish in the diet. One study suggests that omega-3s from walnuts and fish both work to lower heart disease risk, but by different routes. Walnut omega-3s (alpha-linolenic acid, or ALA) help reduce total cholesterol and LDL (bad) cholesterol, while omega-3s from fish (eicosapentaenoic acid, or EPA, and docosahexaenoic acid, or DHA) lower triglycerides and raise HDL (good) cholesterol levels.

Cancer. Hundreds of studies suggest that eating lots of fruits and vegetables can reduce the risk of developing certain cancers, and there's evidence that vegetarians have a lower incidence of cancer than nonvegetarians do. But the differences aren't large. A vegetarian diet can make it easier to get the recommended minimum of five daily servings of fruits and vegetables, but a purely vegetarian diet is not necessarily better than a plant-based diet that also includes fish or poultry. For example, in a pooled analysis of data from the Oxford Vegetarian Study and EPIC-Oxford, fish-eaters had a lower risk of certain cancers than vegetarians.

If you stop eating red meat (whether or not you become a vegetarian), you'll eliminate a risk factor for colon cancer. It's not clear whether avoiding all animal products reduces the risk further. Vegetarians usually have lower levels of potentially carcinogenic substances in their colons, but studies comparing cancer rates in vegetarians and nonvegetarians have shown inconsistent results.

Type 2 diabetes. Research suggests that a predominantly plant-based diet can reduce the risk for type 2 diabetes. In studies of Seventh-day Adventists, vegetarians' risk of developing diabetes was half that of nonvegetarians, even after taking BMI into account. The Harvard-based Women's Health Study found a similar correlation between eating red meat (especially processed meats, such as bacon and hot dogs) and diabetes risk, after adjusting for BMI, total calorie intake, and exercise.

Some women are reluctant to try a vegetarian diet especially one that doesn't include calcium-rich dairy products because they're concerned about osteoporosis. Lacto-ovo vegetarians (see "Varieties of vegetarians") consume at least as much calcium as meat-eaters, but vegans typically consume less. In the EPIC-Oxford study, 75% of vegans got less than the recommended daily amount of calcium, and vegans in general had a relatively high rate of fractures. But vegans who consumed at least 525 milligrams of calcium per day were not especially vulnerable to fractures.

Certain vegetables can supply calcium, including bok choy, broccoli, Chinese cabbage, collards, and kale. (Spinach and Swiss chard, which also contain calcium, are not such good choices, because along with the calcium they have oxalates, which make it harder for the body to absorb calcium.) Moreover, the high potassium and magnesium content of fruits and vegetables reduces blood acidity, lowering the urinary excretion of calcium.

People who follow a vegetarian diet and especially a vegan diet may be at risk of getting insufficient vitamin D and vitamin K, both needed for bone health. Although green leafy vegetables contain some vitamin K, vegans may also need to rely on fortified foods, including some types of soy milk, rice milk, organic orange juice, and breakfast cereals. They may also want to consider taking a vitamin D supplement.

Becoming a vegetarian requires planning and knowledge of plant-based nutrition. Here are some resources that can help:

American Dietetic Associationwww.eatright.org

The Vegetarian Resource Groupwww.vrg.org

Vegetarian Society of the United Kingdomwww.vegsoc.org

Concerns about vegetarian diets have focused mainly on the following nutrients:

Protein. Research shows that lacto-ovo vegetarians generally get the recommended daily amount of protein, which is easily obtained from dairy products and eggs. (Women need about 0.4 grams of protein per pound of body weight per day. Because the protein in vegetables is somewhat different from animal protein, vegans may need 0.45 grams of protein per pound of body weight per day.) There are many plant sources that can help vegans meet their protein needs, including peas, beans, lentils, chickpeas, seeds, nuts, soy products, and whole grains (for example, wheat, oats, barley, and brown rice). Vegetarians used to be told that they had to combine "complementary" plant proteins (rice with beans, for example) at every meal to get all the amino acids contained in meat protein. Now, health experts say that such rigid planning is unnecessary. According to the American Dietetic Association, eating a wide variety of protein sources every day is sufficient.

Vitamin B12. Vitamin B12 is found only in animal products, but those products include dairy foods and eggs, so most vegetarians get all they need. If you avoid animal products altogether, you should eat foods fortified with vitamin B12 (certain soy and rice beverages and breakfast cereals) or take a vitamin B12 supplement to avoid a deficiency, which can cause neurological problems and pernicious anemia.

Iron. Studies show that in Western countries, vegetarians tend to get the same amount of iron as meat eaters. But the iron in meat (especially red meat) is more readily absorbed than the kind found in plant foods, known as non-heme iron. The absorption of non-heme iron is enhanced by vitamin C and other acids found in fruits and vegetables, but it may be inhibited by the phytic acid in whole grains, beans, lentils, seeds, and nuts.

Zinc. Phytic acid in whole grains, seeds, beans, and legumes also reduces zinc absorption, but vegetarians in Western countries do not appear to be zinc-deficient.

Omega-3 fatty acids. Diets that include no fish or eggs are low in EPA and DHA. Our bodies can convert ALA in plant foods to EPA and DHA, but not very efficiently. Vegans can get DHA from algae supplements, which increase blood levels of DHA as well as EPA (by a process called retroversion). DHA-fortified breakfast bars and soy milk are also available. Official dietary guidelines recommend 1.10 grams per day of ALA for women, but vegetarians who consume little or no EPA and DHA should probably get more than that. Good ALA sources include flaxseed, walnuts, canola oil, and soy.

For more on eating for optimum health, buy the Harvard Special Health Report Healthy Eating: A guide to the new nutrition.

Disclaimer:As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review on all articles. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.

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Becoming a vegetarian - Harvard Health

Vegetarianism (for Parents) – KidsHealth

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Vegetarianism is a popular choice for many individuals and families. But parents may wonder if kids can safely follow a vegetarian diet and still get all necessary nutrients. Most dietary and medical experts agree that a well-planned vegetarian diet can actually be a very healthy way to eat.

But special care must be taken when serving kids and teens a vegetarian diet, especially if it doesn't include dairy and egg products. And as with any diet, you'll need to understand that the nutritional needs of kids change as they grow.

Before your child or family switches to a vegetarian diet, it's important to note that all vegetarian diets are not alike. Major vegetarian categories include:

And many other people are semi-vegetarians who have eliminated red meat, but may eat poultry or fish.

Kids or families may follow a vegetarian diet for a variety of reasons. Younger vegetarians are usually part of a family that eats vegetarian meals for health, cultural, or other reasons. Older kids may decide to become vegetarians because of concern for animals, the environment, or their own health.

In most cases, you shouldn't be alarmed if your child chooses vegetarianism. Discuss what it means and how to implement it, ensuring your child makes healthy and nutritious food choices.

Your doctor or a registered dietitian can help you plan and monitor a healthy vegetarian diet. Parents should give their kids a variety of foods that provide enough calories and nutrients to enable them to grow normally.

A well-planned vegetarian diet can meet kids' nutritional needs and has some health benefits. For example, a diet rich in fruits and veggies will be high in fiber and low in fat, factors known to improve cardiovascular health by reducing blood cholesterol and maintaining a healthy weight. However, kids and teens on a vegetarian diet may need to be careful that they get an adequate amount of certain vitamins and minerals.

Here are nutrients that vegetarians should get and some of their best food sources:

Depending on the type of vegetarian diet chosen, kids may miss out on some of these important nutrients if the diet isn't monitored by the parents. The less restrictive the vegetarian diet, the easier it will be for your child to get enough of the necessary nutrients. In some cases, fortified foods or supplements can help meet nutritional needs.

The main sources of protein and nutrients for infants are breast milk and formula (soy formula for vegan infants), especially in the first 6 months of life. Breastfed infant vegans should receive a source of vitamin B12 if the mother's diet isn't supplemented, and breastfed infants and infants drinking less than 32 ounces (1 liter) formula should get vitamin D supplements.

Guidelines for the introduction of solid foods are the same for vegetarian and nonvegetarian infants. Breastfed infants 6 months and older should receive iron from complementary foods, such as iron-fortified infant cereal.

Once an infant is introduced to solids, protein-rich vegetarian foods can include pureed tofu, cottage cheese, yogurt or soy yogurt, and pureed and strained legumes (legumes include beans, peas, chickpeas, and lentils).

Toddlers are already a challenge when it comes to eating. As they come off of breast milk or formula, kids are at risk for nutritional deficiencies. After the age of 1, strict vegan diets may not offer growing toddlers enough essential vitamins and minerals, such as vitamin D, vitamin B12, iron, calcium, and zinc.

So it's important to serve fortified cereals and nutrient-dense foods. Vitamin supplementation is recommended for young children whose diets may not provide adequate nutrients.

Toddlers are typically picky about which foods they'll eat and, as a result, some may not get enough calories from a vegetarian diet to thrive. For vegan toddlers, the amount of vegetables needed for proper nutrition and calories may be too bulky for their tiny stomachs.

During the picky toddler stage, it's important for vegetarian parents to make sure their young child eats enough calories. You can get enough fat and calories in a vegan child's diet, but you have to plan carefully.

Preteens and teens often voice their independence through the foods they choose to eat. One strong statement is the decision to stop eating meat. This is common among teens, who may decide to embrace vegetarianism in support of animal rights, for health reasons, or because friends are doing it.

If it's done right, a meat-free diet can actually be a good choice for adolescents, especially considering that vegetarians often eat more of the foods that most teens don't get enough of fruits and vegetables.

A vegetarian diet that includes dairy products and eggs (lacto-ovo) is the best choice for growing teens. A more strict vegetarian diet may fail to meet a teen's need for certain nutrients, such as iron, zinc, calcium, and vitamins D and B12. If you're concerned that your child is not getting enough of these important nutrients, talk to your doctor, who may recommend a vitamin and mineral supplement.

The good news for young vegetarians and their parents is that many schools are offering vegetarian fare, including salad bars and other healthy vegetarian choices. Schools publish lists of upcoming lunch menus; be sure to scan them to see if your child will have a vegetarian choice. If not, you can pack lunch.

If your vegetarian preteen or teen would rather make his or her own school lunch or opts to buy lunch, keep in mind that your child's idea of a healthy vegetarian meal may be much different from yours (e.g., french fries and a soda). Talk to your child about the importance of eating right, especially when following a vegetarian diet.

Also be wary if your child has self-imposed a very restrictive diet. A teen with an eating disorder may drastically reduce calories or cut out all fat or carbohydrates and call it "vegetarianism" because it's considered socially acceptable and healthy.

Even if preteens or teens are approaching vegetarianism in a healthy way, it's still important for them to understand which nutrients might be missing in their diet. To support your child's dietary decision and promote awareness of the kinds of foods your preteen or teen should be eating, consider having the whole family eat a vegetarian meal at least one night a week.

A vegetarian diet can be a healthy choice for all kids, as long as it's properly planned.

The principles of planning a vegetarian diet are the same as planning any healthy diet provide a variety of foods and include foods from all of the food groups. A balanced diet will provide the right combinations to meet nutritional needs. But be aware of potential nutrient deficiencies in your child's diet and figure out how you'll account for them. With a little exploration, you may find more vegetarian options than you realized.

If you aren't sure your child is getting all necessary nutrients or if you have any questions about vegetarian diets, check in with your family doctor, pediatrician, or a registered dietitian.

Date reviewed: October 2014

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Vegetarianism (for Parents) - KidsHealth

vegetarianism | History, Types, & Facts | Britannica.com

Vegetarianism, the theory or practice of living solely upon vegetables, fruits, grains, legumes, and nutswith or without the addition of milk products and eggsgenerally for ethical, ascetic, environmental, or nutritional reasons. All forms of flesh (meat, fowl, and seafood) are excluded from all vegetarian diets, but many vegetarians use milk and milk products; those in the West usually eat eggs also, but most vegetarians in India exclude them, as did those in the Mediterranean lands in Classical times. Vegetarians who exclude animal products altogether (and likewise avoid animal-derived products such as leather, silk, honey, and wool) are known as vegans. Those who use milk products are sometimes called lacto-vegetarians, and those who use eggs as well are called lacto-ovo vegetarians. Among some agricultural peoples, flesh eating has been infrequent except among the privileged classes; such people have rather misleadingly been called vegetarians.

Deliberate avoidance of flesh eating probably first appeared sporadically in ritual connections, either as a temporary purification or as qualification for a priestly function. Advocacy of a regular fleshless diet began about the middle of the 1st millennium bce in India and the eastern Mediterranean as part of the philosophical awakening of the time. In the Mediterranean, avoidance of flesh eating is first recorded as a teaching of the philosopher Pythagoras of Samos (c. 530 bce), who alleged the kinship of all animals as one basis for human benevolence toward other creatures. From Plato onward many pagan philosophers (e.g., Epicurus and Plutarch), especially the Neoplatonists, recommended a fleshless diet; the idea carried with it condemnation of bloody sacrifices in worship and was often associated with belief in the reincarnation of souls and, more generally, with a search for principles of cosmic harmony in accord with which human beings could live. In India, followers of Buddhism and Jainism refused on ethical and ascetic grounds to kill animals for food. Human beings, they believed, should not inflict harm on any sentient creature. This principle was soon taken up in Brahmanism and, later, Hinduism and was applied especially to the cow. As in Mediterranean thought, the idea carried with it condemnation of bloody sacrifices and was often associated with principles of cosmic harmony.

In later centuries the history of vegetarianism in the Indic and Mediterranean regions diverged significantly. In India itself, though Buddhism gradually declined, the ideal of harmlessness (ahimsa), with its corollary of a fleshless diet, spread steadily in the 1st millennium ce until many of the upper castes, and even some of the lower, had adopted it. Beyond India it was carried, with Buddhism, northward and eastward as far as China and Japan. In some countries, fish were included in an otherwise fleshless diet.

West of the Indus the great monotheistic traditions were less favourable to vegetarianism. The Hebrew Bible, however, records the belief that in paradise the earliest human beings had not eaten flesh. Ascetic Jewish groups and some early Christian leaders disapproved of flesh eating as gluttonous, cruel, and expensive. Some Christian monastic orders ruled out flesh eating, and its avoidance has been a penance and a spiritual exercise even for laypersons. A number of saints, such as St. Anthony of Egypt, were noted vegetarians. Many Muslims have been hostile to vegetarianism, yet some Muslim Sufi mystics recommended a meatless diet for spiritual seekers.

The 17th and 18th centuries in Europe were characterized by a greater interest in humanitarianism and the idea of moral progress, and sensitivity to animal suffering was accordingly revived. Certain Protestant groups came to adopt a fleshless diet as part of the goal of leading a perfectly sinless life. Persons of diverse philosophical views advocated vegetarianism; for example, Voltaire praised it, and Percy Bysshe Shelley and Henry David Thoreau practiced the diet. In the late 18th century the utilitarian philosopher Jeremy Bentham asserted that the suffering of animals, like the suffering of humans, was worthy of moral consideration, and he regarded cruelty to animals as analogous to racism.

Vegetarians of the early 19th century usually condemned the use of alcohol as well as flesh and appealed as much to nutritional advantages as to ethical sensibilities. As before, vegetarianism tended to be combined with other efforts toward a humane and cosmically harmonious way of life. Although the vegetarian movement as a whole was always carried forward by ethically inclined individuals, special institutions grew up to express vegetarian concerns as such. The first vegetarian society was formed in England in 1847 by the Bible Christian sect, and the International Vegetarian Union was founded tentatively in 1889 and more enduringly in 1908.

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Protein folding – Wikipedia

"Protein thermodynamics" redirects here. For the thermodynamics of reactions catalyzed by proteins, see Enzyme.

Protein folding is the physical process by which a protein chain acquires its native 3-dimensional structure, a conformation that is usually biologically functional, in an expeditious and reproducible manner. It is the physical process by which a polypeptide folds into its characteristic and functional three-dimensional structure from random coil.[1]Each protein exists as an unfolded polypeptide or random coil when translated from a sequence of mRNA to a linear chain of amino acids. This polypeptide lacks any stable (long-lasting) three-dimensional structure (the left hand side of the first figure). As the polypeptide chain is being synthesized by a ribosome, the linear chain begins to fold into its three-dimensional structure. Folding begins to occur even during translation of the polypeptide chain. Amino acids interact with each other to produce a well-defined three-dimensional structure, the folded protein (the right hand side of the figure), known as the native state. The resulting three-dimensional structure is determined by the amino acid sequence or primary structure (Anfinsen's dogma).[2]

The correct three-dimensional structure is essential to function, although some parts of functional proteins may remain unfolded,[3] so that protein dynamics is important. Failure to fold into native structure generally produces inactive proteins, but in some instances misfolded proteins have modified or toxic functionality. Several neurodegenerative and other diseases are believed to result from the accumulation of amyloid fibrils formed by misfolded proteins.[4] Many allergies are caused by incorrect folding of some proteins, because the immune system does not produce antibodies for certain protein structures.[5]

Denaturation of proteins is a process of transition from the folded to the unfolded state. It happens in cooking, in burns, in proteinopathies, and in other contexts.[6]

The duration of the folding process varies dramatically depending on the protein of interest. When studied outside the cell, the slowest folding proteins require many minutes or hours to fold primarily due to proline isomerization, and must pass through a number of intermediate states, like checkpoints, before the process is complete.[7] On the other hand, very small single-domain proteins with lengths of up to a hundred amino acids typically fold in a single step.[8] Time scales of milliseconds are the norm and the very fastest known protein folding reactions are complete within a few microseconds.[9]

The primary structure of a protein, its linear amino-acid sequence, determines its native conformation.[10] The specific amino acid residues and their position in the polypeptide chain are the determining factors for which portions of the protein fold closely together and form its three-dimensional conformation. The amino acid composition is not as important as the sequence.[11] The essential fact of folding, however, remains that the amino acid sequence of each protein contains the information that specifies both the native structure and the pathway to attain that state. This is not to say that nearly identical amino acid sequences always fold similarly.[12] Conformations differ based on environmental factors as well; similar proteins fold differently based on where they are found.

Formation of a secondary structure is the first step in the folding process that a protein takes to assume its native structure. Characteristic of secondary structure are the structures known as alpha helices and beta sheets that fold rapidly because they are stabilized by intramolecular hydrogen bonds, as was first characterized by Linus Pauling. Formation of intramolecular hydrogen bonds provides another important contribution to protein stability.[13] -helices are formed by hydrogen bonding of the backbone to form a spiral shape (refer to figure on the right).[11] The pleated sheet is a structure that forms with the backbone bending over itself to form the hydrogen bonds (as displayed in the figure to the left). The hydrogen bonds are between the amide hydrogen and carbonyl oxygen of the peptide bond. There exists anti-parallel pleated sheets and parallel pleated sheets where the stability of the hydrogen bonds is stronger in the anti-parallel sheet as it hydrogen bonds with the ideal 180 degree angle compared to the slanted hydrogen bonds formed by parallel sheets.[11]

The alpha helices and beta pleated sheets can be amphipathic in nature, or contain a hydrophilic portion and a hydrophobic portion. This property of secondary structures aids in the tertiary structure of a protein in which the folding occurs so that the hydrophilic sides are facing the aqueous environment surrounding the protein and the hydrophobic sides are facing the hydrophobic core of the protein.[14] Secondary structure hierarchically gives way to tertiary structure formation. Once the protein's tertiary structure is formed and stabilized by the hydrophobic interactions, there may also be covalent bonding in the form of disulfide bridges formed between two cysteine residues. Tertiary structure of a protein involves a single polypeptide chain; however, additional interactions of folded polypeptide chains give rise to quaternary structure formation.[15]

Tertiary structure may give way to the formation of quaternary structure in some proteins, which usually involves the "assembly" or "coassembly" of subunits that have already folded; in other words, multiple polypeptide chains could interact to form a fully functional quaternary protein.[11]

Folding is a spontaneous process that is mainly guided by hydrophobic interactions, formation of intramolecular hydrogen bonds, van der Waals forces, and it is opposed by conformational entropy.[16] The process of folding often begins co-translationally, so that the N-terminus of the protein begins to fold while the C-terminal portion of the protein is still being synthesized by the ribosome; however, a protein molecule may fold spontaneously during or after biosynthesis.[17] While these macromolecules may be regarded as "folding themselves", the process also depends on the solvent (water or lipid bilayer),[18] the concentration of salts, the pH, the temperature, the possible presence of cofactors and of molecular chaperones.Proteins will have limitations on their folding abilities by the restricted bending angles or conformations that are possible. These allowable angles of protein folding are described with a two-dimensional plot known as the Ramachandran plot, depicted with psi and phi angles of allowable rotation.[19]

Protein folding must be thermodynamically favorable within a cell in order for it to be a spontaneous reaction. Since it is known that protein folding is a spontaneous reaction, then it must assume a negative Gibbs free energy value. Gibbs free energy in protein folding is directly related to enthalpy and entropy.[11] For a negative delta G to arise and for protein folding to become thermodynamically favorable, then either enthalpy, entropy, or both terms must be favorable.

Minimizing the number of hydrophobic side-chains exposed to water is an important driving force behind the folding process.[20] The hydrophobic effect is the phenomenon in which the hydrophobic chains of a protein collapse into the core of the protein (away from the hydrophilic environment).[11] In an aqueous environment, the water molecules tend to aggregate around the hydrophobic regions or side chains of the protein, creating water shells of ordered water molecules.[21] An ordering of water molecules around a hydrophobic region increases order in a system and therefore contributes a negative change in entropy (less entropy in the system). The water molecules are fixed in these water cages which drives the hydrophobic collapse, or the inward folding of the hydrophobic groups. The hydrophobic collapse introduces entropy back to the system via the breaking of the water cages which frees the ordered water molecules.[11] The multitude of hydrophobic groups interacting within the core of the globular folded protein contributes a significant amount to protein stability after folding, because of the vastly accumulated van der Waals forces (specifically London Dispersion forces).[11] The hydrophobic effect exists as a driving force in thermodynamics only if there is the presence of an aqueous medium with an amphiphilic molecule containing a large hydrophobic region.[22] The strength of hydrogen bonds depends on their environment; thus, H-bonds enveloped in a hydrophobic core contribute more than H-bonds exposed to the aqueous environment to the stability of the native state.[23]

In proteins with globular folds, hydrophobic amino acids tend to be interspersed along the primary sequence, rather than randomly distributed or clustered together.[24][25] However, proteins that have recently been born de novo, which tend to be intrinsically disordered[26][27], show the opposite pattern of hydrophobic amino acid clustering along the primary sequence.[28]

Molecular chaperones are a class of proteins that aid in the correct folding of other proteins in vivo. Chaperones exist in all cellular compartments and interact with the polypeptide chain in order to allow the native three-dimensional conformation of the protein to form; however, chaperones themselves are not included in the final structure of the protein they are assisting in.[29] Chaperones may assist in folding even when the nascent polypeptide is being synthesized by the ribosome.[30] Molecular chaperones operate by binding to stabilize an otherwise unstable structure of a protein in its folding pathway, but chaperones do not contain the necessary information to know the correct native structure of the protein they are aiding; rather, chaperones work by preventing incorrect folding conformations.[30] In this way, chaperones do not actually increase the rate of individual steps involved in the folding pathway toward the native structure; instead, they work by reducing possible unwanted aggregations of the polypeptide chain that might otherwise slow down the search for the proper intermediate and they provide a more efficient pathway for the polypeptide chain to assume the correct conformations.[29] Chaperones are not to be confused with folding catalysts, which actually do catalyze the otherwise slow steps in the folding pathway. Examples of folding catalysts are protein disulfide isomerases and peptidyl-prolyl isomerases that may be involved in formation of disulfide bonds or interconversion between cis and trans stereoisomers, respectively.[30] Chaperones are shown to be critical in the process of protein folding in vivo because they provide the protein with the aid needed to assume its proper alignments and conformations efficiently enough to become "biologically relevant".[31] This means that the polypeptide chain could theoretically fold into its native structure without the aid of chaperones, as demonstrated by protein folding experiments conducted in vitro;[31] however, this process proves to be too inefficient or too slow to exist in biological systems; therefore, chaperones are necessary for protein folding in vivo. Along with its role in aiding native structure formation, chaperones are shown to be involved in various roles such as protein transport, degradation, and even allow denatured proteins exposed to certain external denaturant factors an opportunity to refold into their correct native structures.[32]

A fully denatured protein lacks both tertiary and secondary structure, and exists as a so-called random coil. Under certain conditions some proteins can refold; however, in many cases, denaturation is irreversible.[33] Cells sometimes protect their proteins against the denaturing influence of heat with enzymes known as heat shock proteins (a type of chaperone), which assist other proteins both in folding and in remaining folded. Some proteins never fold in cells at all except with the assistance of chaperones which either isolate individual proteins so that their folding is not interrupted by interactions with other proteins or help to unfold misfolded proteins, allowing them to refold into the correct native structure.[34] This function is crucial to prevent the risk of precipitation into insoluble amorphous aggregates. The external factors involved in protein denaturation or disruption of the native state include temperature, external fields (electric, magnetic),[35] molecular crowding,[36] and even the limitation of space, which can have a big influence on the folding of proteins.[37] High concentrations of solutes, extremes of pH, mechanical forces, and the presence of chemical denaturants can contribute to protein denaturation, as well. These individual factors are categorized together as stresses. Chaperones are shown to exist in increasing concentrations during times of cellular stress and help the proper folding of emerging proteins as well as denatured or misfolded ones.[29]

Under some conditions proteins will not fold into their biochemically functional forms. Temperatures above or below the range that cells tend to live in will cause thermally unstable proteins to unfold or denature (this is why boiling makes an egg white turn opaque). Protein thermal stability is far from constant, however; for example, hyperthermophilic bacteria have been found that grow at temperatures as high as 122C,[38] which of course requires that their full complement of vital proteins and protein assemblies be stable at that temperature or above.

A protein is considered to be misfolded if it cannot achieve its normal native state. This can be due to mutations in the amino acid sequence or a disruption of the normal folding process by external factors.[39] The misfolded protein typically contains -sheets that are organized in a supramolecular arrangement known as a cross- structure. These -sheet-rich assemblies are very stable, very insoluble, and generally resistant to proteolysis.[40] The structural stability of these fibrillar assemblies is caused by extensive interactions between the protein monomers, formed by backbone hydrogen bonds between their -strands.[40] The misfolding of proteins can trigger the further misfolding and accumulation of other proteins into aggregates or oligomers. The increased levels of aggregated proteins in the cell leads to formation of amyloid-like structures which can cause degenerative disorders and cell death.[39] The amyloids are fibrillary structures that contain intermolecular hydrogen bonds which are highly insoluble and made from converted protein aggregates.[39] Therefore, the proteasome pathway may not be efficient enough to degrade the misfolded proteins prior to aggregation. Misfolded proteins can interact with one another and form structured aggregates and gain toxicity through intermolecular interactions.[39]

Aggregated proteins are associated with prion-related illnesses such as CreutzfeldtJakob disease, bovine spongiform encephalopathy (mad cow disease), amyloid-related illnesses such as Alzheimer's disease and familial amyloid cardiomyopathy or polyneuropathy,[41] as well as intracellular aggregation diseases such as Huntington's and Parkinson's disease.[4][42] These age onset degenerative diseases are associated with the aggregation of misfolded proteins into insoluble, extracellular aggregates and/or intracellular inclusions including cross- amyloid fibrils. It is not completely clear whether the aggregates are the cause or merely a reflection of the loss of protein homeostasis, the balance between synthesis, folding, aggregation and protein turnover. Recently the European Medicines Agency approved the use of Tafamidis or Vyndaqel (a kinetic stabilizer of tetrameric transthyretin) for the treatment of transthyretin amyloid diseases. This suggests that the process of amyloid fibril formation (and not the fibrils themselves) causes the degeneration of post-mitotic tissue in human amyloid diseases.[43] Misfolding and excessive degradation instead of folding and function leads to a number of proteopathy diseases such as antitrypsin-associated emphysema, cystic fibrosis and the lysosomal storage diseases, where loss of function is the origin of the disorder. While protein replacement therapy has historically been used to correct the latter disorders, an emerging approach is to use pharmaceutical chaperones to fold mutated proteins to render them functional.

While inferences about protein folding can be made through mutation studies, typically, experimental techniques for studying protein folding rely on the gradual unfolding or folding of proteins and observing conformational changes using standard non-crystallographic techniques.

X-ray crystallography is one of the more efficient and important methods for attempting to decipher the three dimensional configuration of a folded protein.[44] To be able to conduct X-ray crystallography, the protein under investigation must be located inside a crystal lattice. To place a protein inside a crystal lattice, one must have a suitable solvent for crystallization, obtain a pure protein at supersaturated levels in solution, and precipitate the crystals in solution.[45] Once a protein is crystallized, x-ray beams can be concentrated through the crystal lattice which would diffract the beams or shoot them outwards in various directions. These exiting beams are correlated to the specific three-dimensional configuration of the protein enclosed within. The x-rays specifically interact with the electron clouds surrounding the individual atoms within the protein crystal lattice and produce a discernible diffraction pattern.[14] Only by relating the electron density clouds with the amplitude of the x-rays can this pattern be read and lead to assumptions of the phases or phase angles involved that complicate this method.[46] Without the relation established through a mathematical basis known as Fourier transform, the "phase problem" would render predicting the diffraction patterns very difficult.[14] Emerging methods like multiple isomorphous replacement use the presence of a heavy metal ion to diffract the x-rays into a more predictable manner, reducing the number of variables involved and resolving the phase problem.[44]

Fluorescence spectroscopy is a highly sensitive method for studying the folding state of proteins. Three amino acids, phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp), have intrinsic fluorescence properties, but only Tyr and Trp are used experimentally because their quantum yields are high enough to give good fluorescence signals. Both Trp and Tyr are excited by a wavelength of 280nm, whereas only Trp is excited by a wavelength of 295nm. Because of their aromatic character, Trp and Tyr residues are often found fully or partially buried in the hydrophobic core of proteins, at the interface between two protein domains, or at the interface between subunits of oligomeric proteins. In this apolar environment, they have high quantum yields and therefore high fluorescence intensities. Upon disruption of the proteins tertiary or quaternary structure, these side chains become more exposed to the hydrophilic environment of the solvent, and their quantum yields decrease, leading to low fluorescence intensities. For Trp residues, the wavelength of their maximal fluorescence emission also depend on their environment.

Fluorescence spectroscopy can be used to characterize the equilibrium unfolding of proteins by measuring the variation in the intensity of fluorescence emission or in the wavelength of maximal emission as functions of a denaturant value.[47][48] The denaturant can be a chemical molecule (urea, guanidinium hydrochloride), temperature, pH, pressure, etc. The equilibrium between the different but discrete protein states, i.e. native state, intermediate states, unfolded state, depends on the denaturant value; therefore, the global fluorescence signal of their equilibrium mixture also depends on this value. One thus obtains a profile relating the global protein signal to the denaturant value. The profile of equilibrium unfolding may enable one to detect and identify intermediates of unfolding.[49][50] General equations have been developed by Hugues Bedouelle to obtain the thermodynamic parameters that characterize the unfolding equilibria for homomeric or heteromeric proteins, up to trimers and potentially tetramers, from such profiles.[47] Fluorescence spectroscopy can be combined with fast-mixing devices such as stopped flow, to measure protein folding kinetics,[51] generate a chevron plot and derive a Phi value analysis.

Circular dichroism is one of the most general and basic tools to study protein folding. Circular dichroism spectroscopy measures the absorption of circularly polarized light. In proteins, structures such as alpha helices and beta sheets are chiral, and thus absorb such light. The absorption of this light acts as a marker of the degree of foldedness of the protein ensemble. This technique has been used to measure equilibrium unfolding of the protein by measuring the change in this absorption as a function of denaturant concentration or temperature. A denaturant melt measures the free energy of unfolding as well as the protein's m value, or denaturant dependence. A temperature melt measures the denaturation temperature (Tm) of the protein.[47] As for fluorescence spectroscopy, circular-dichroism spectroscopy can be combined with fast-mixing devices such as stopped flow to measure protein folding kinetics and to generate chevron plots.

The more recent developments of vibrational circular dichroism (VCD) techniques for proteins, currently involving Fourier transform (FFT) instruments, provide powerful means for determining protein conformations in solution even for very large protein molecules. Such VCD studies of proteins are often combined with X-ray diffraction of protein crystals, FT-IR data for protein solutions in heavy water (D2O), or ab initio quantum computations to provide unambiguous structural assignments that are unobtainable from CD.[citation needed]

Protein folding is routinely studied using NMR spectroscopy, for example by monitoring hydrogen-deuterium exchange of backbone amide protons of proteins in their native state, which provides both the residue-specific stability and overall stability of proteins.[52]

Dual polarisation interferometry is a surface-based technique for measuring the optical properties of molecular layers. When used to characterize protein folding, it measures the conformation by determining the overall size of a monolayer of the protein and its density in real time at sub-Angstrom resolution,[53] although real-time measurement of the kinetics of protein folding are limited to processes that occur slower than ~10Hz. Similar to circular dichroism, the stimulus for folding can be a denaturant or temperature.

The study of protein folding has been greatly advanced in recent years by the development of fast, time-resolved techniques. Experimenters rapidly trigger the folding of a sample of unfolded protein and observe the resulting dynamics. Fast techniques in use include neutron scattering,[54] ultrafast mixing of solutions, photochemical methods, and laser temperature jump spectroscopy. Among the many scientists who have contributed to the development of these techniques are Jeremy Cook, Heinrich Roder, Harry Gray, Martin Gruebele, Brian Dyer, William Eaton, Sheena Radford, Chris Dobson, Alan Fersht, Bengt Nlting and Lars Konermann.

Proteolysis is routinely used to probe the fraction unfolded under a wide range of solution conditions (e.g. Fast parallel proteolysis (FASTpp).[55][56]

Single molecule techniques such as optical tweezers and AFM have been used to understand protein folding mechanisms of isolated proteins as well as proteins with chaperones.[57] Optical tweezers have been used to stretch single protein molecules from their C- and N-termini and unfold them to allow study of the subsequent refolding.[58] The technique allows one to measure folding rates at single-molecule level; for example, optical tweezers have been recently applied to study folding and unfolding of proteins involved in blood coagulation. von Willebrand factor (vWF) is a protein with an essential role in blood clot formation process. It discovered using single molecule optical tweezers measurement that calcium-bound vWF acts as a shear force sensor in the blood. Shear force leads to unfolding of the A2 domain of vWF, whose refolding rate is dramatically enhanced in the presence of calcium.[59] Recently, it was also shown that the simple src SH3 domain accesses multiple unfolding pathways under force.[60]

Biotin painting enables condition-specific cellular snapshots of (un)folded proteins. Biotin 'painting' shows a bias towards predicted Intrinsically disordered proteins [61].

Computational studies of protein folding includes three main aspects related to the prediction of protein stability, kinetics, and structure. A recent review summarizes the available computational methods for protein folding. [62]

In 1969, Cyrus Levinthal noted that, because of the very large number of degrees of freedom in an unfolded polypeptide chain, the molecule has an astronomical number of possible conformations. An estimate of 3300 or 10143 was made in one of his papers.[63] Levinthal's paradox is a thought experiment based on the observation that if a protein were folded by sequentially sampling of all possible conformations, it would take an astronomical amount of time to do so, even if the conformations were sampled at a rapid rate (on the nanosecond or picosecond scale).[64] Based upon the observation that proteins fold much faster than this, Levinthal then proposed that a random conformational search does not occur, and the protein must, therefore, fold through a series of meta-stable intermediate states.

The configuration space of a protein during folding can be visualized as energy landscape. According to Joseph Bryngelson and Peter Wolynes, proteins follow the principle of minimal frustration meaning that naturally evolved proteins have optimized their folding energy landscapes.[65], and that nature has chosen amino acid sequences so that the folded state of the protein is sufficiently stable. In addition, the acquisition of the folded state had to become a sufficiently fast process. Even though nature has reduced the level of frustration in proteins, some degree of it remains up to now as can be observed in the presence of local minima in the energy landscape of proteins.

A consequence of these evolutionarily selected sequences is that proteins are generally thought to have globally "funneled energy landscapes" (coined by Jos Onuchic)[66] that are largely directed toward the native state. This "folding funnel" landscape allows the protein to fold to the native state through any of a large number of pathways and intermediates, rather than being restricted to a single mechanism. The theory is supported by both computational simulations of model proteins and experimental studies,[65] and it has been used to improve methods for protein structure prediction and design.[65] The description of protein folding by the leveling free-energy landscape is also consistent with the 2nd law of thermodynamics.[67] Physically, thinking of landscapes in terms of visualizable potential or total energy surfaces simply with maxima, saddle points, minima, and funnels, rather like geographic landscapes, is perhaps a little misleading. The relevant description is really a high-dimensional phase space in which manifolds might take a variety of more complicated topological forms.[68]

The unfolded polypeptide chain begins at the top of the funnel where it may assume the largest number of unfolded variations and is in its highest energy state. Energy landscapes such as these indicate that there are a large number of initial possibilities, but only a single native state is possible; however, it does not reveal the numerous folding pathways that are possible. A different molecule of the same exact protein may be able to follow marginally different folding pathways, seeking different lower energy intermediates, as long as the same native structure is reached.[69] Different pathways may have different frequencies of utilization depending on the thermodynamic favorability of each pathway. This means that if one pathway is found to be more thermodynamically favorable than another, it is likely to be used more frequently in the pursuit of the native structure.[69] As the protein begins to fold and assume its various conformations, it always seeks a more thermodynamically favorable structure than before and thus continues through the energy funnel. Formation of secondary structures is a strong indication of increased stability within the protein, and only one combination of secondary structures assumed by the polypeptide backbone will have the lowest energy and therefore be present in the native state of the protein.[69] Among the first structures to form once the polypeptide begins to fold are alpha helices and beta turns, where alpha helices can form in as little as 100 nanoseconds and beta turns in 1 microsecond.[29]

There exists a saddle point in the energy funnel landscape where the transition state for a particular protein is found.[29] The transition state in the energy funnel diagram is the conformation that must be assumed by every molecule of that protein if the protein wishes to finally assume the native structure. No protein may assume the native structure without first passing through the transition state.[29] The transition state can be referred to as a variant or premature form of the native state rather than just another intermediary step.[70] The folding of the transition state is shown to be rate-determining, and even though it exists in a higher energy state than the native fold, it greatly resembles the native structure. Within the transition state, there exists a nucleus around which the protein is able to fold, formed by a process referred to as "nucleation condensation" where the structure begins to collapse onto the nucleus.[70]

De novo or ab initio techniques for computational protein structure prediction are related to, but strictly distinct from, experimental studies of protein folding. Molecular Dynamics (MD) is an important tool for studying protein folding and dynamics in silico.[71] First equilibrium folding simulations were done using implicit solvent model and umbrella sampling.[72] Because of computational cost, ab initio MD folding simulations with explicit water are limited to peptides and very small proteins.[73][74] MD simulations of larger proteins remain restricted to dynamics of the experimental structure or its high-temperature unfolding. Long-time folding processes (beyond about 1 millisecond), like folding of small-size proteins (about 50 residues) or larger, can be accessed using coarse-grained models.[75][76][77]

The 100-petaFLOP distributed computing project Folding@home created by Vijay Pande's group at Stanford University simulates protein folding using the idle processing time of CPUs and GPUs of personal computers from volunteers. The project aims to understand protein misfolding and accelerate drug design for disease research.

Long continuous-trajectory simulations have been performed on Anton, a massively parallel supercomputer designed and built around custom ASICs and interconnects by D. E. Shaw Research. The longest published result of a simulation performed using Anton is a 2.936 millisecond simulation of NTL9 at 355 K.[78]

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Veganism – Wikipedia

the practice of abstaining from animal products and a philosophy that rejects animal commodification

Veganism is the practice of abstaining from the use of animal products, particularly in diet, and an associated philosophy that rejects the commodity status of animals.[b] A follower of the diet or the philosophy is known as a vegan.[c] Distinctions may be made between several categories of veganism. Dietary vegans (also known as strict vegetarians) refrain from consuming animal products, not only meat but also eggs, dairy products and other animal-derived substances.[d] The term ethical vegan is often applied to those who not only follow a vegan diet but extend the philosophy into other areas of their lives, and oppose the use of animals for any purpose.[e] Another term is environmental veganism, which refers to the avoidance of animal products on the premise that the industrial farming of animals is environmentally damaging and unsustainable.[22]

Well-planned vegan diets are regarded as appropriate for all stages of life, including during infancy and pregnancy, by the American Academy of Nutrition and Dietetics,[f] Dietitians of Canada,[24] Australian National Health and Medical Research Council,[25] New Zealand Ministry of Health,[26] Harvard Medical School,[27] and the British Dietetic Association.[28] The German Society for Nutrition does not recommend vegan diets for children or adolescents, or during pregnancy and breastfeeding.[g] In preliminary clinical research, vegan diets[clarification needed] lowered the risk of type 2 diabetes, high blood pressure, obesity, and ischemic heart disease.[30][31][32][33] Vegan diets tend to be higher[clarification needed] in dietary fiber, magnesium, folic acid, vitamin C, vitamin E, iron, and phytochemicals; and lower in dietary energy, saturated fat, cholesterol, long-chain omega-3 fatty acids, vitamin D, calcium, zinc, and vitamin B12.[h] As with any poorly-planned diet, unbalanced vegan diets may lead to nutritional deficiencies that nullify any beneficial effects and may cause serious health issues.[34][35][36] Some of these deficiencies can only be prevented through the choice of fortified foods or the regular intake of dietary supplements.[34][37] Vitamin B12 supplementation is especially important because its deficiency causes blood disorders and potentially irreversible neurological damage.[36][38][39]

Donald Watson coined the term vegan in 1944 when he co-founded the Vegan Society in England. At first he used it to mean "non-dairy vegetarian",[40][41] and by May 1945 vegans explicitly abstained from "eggs, honey; and animals' milk, butter and cheese". From 1951 the Society defined it as "the doctrine that man should live without exploiting animals".[42] Interest in veganism increased in the 2010s,[43][44] especially in the latter half.[44] More vegan stores opened and vegan options became increasingly available in supermarkets and restaurants in many countries.

The term "vegetarian" has been in use since around 1839 to refer to what was previously described as a vegetable regimen or diet.[45] Modern dictionaries based on scientific linguistic principles explain its origin as an irregular compound of vegetable[46] and the suffix -arian (in the sense of "supporter, believer" as in humanitarian).[47] The earliest-known written use is attributed to actress, writer and abolitionist Fanny Kemble, in her Journal of a Residence on a Georgian plantation in 18381839.[i]

The practice can be traced to Indus Valley Civilization in 33001300 BCE in the Indian subcontinent,[50][51][52] particularly in northern and western ancient India.[53] Early vegetarians included Indian philosophers such as Mahavira and Acharya Kundakunda, the Tamil poet Valluvar, the Indian emperors Chandragupta Maurya and Ashoka; Greek philosophers such as Empedocles, Theophrastus, Plutarch, Plotinus, and Porphyry; and the Roman poet Ovid and the playwright Seneca the Younger.[54][55] The Greek sage Pythagoras may have advocated an early form of strict vegetarianism,[56][57] but his life is so obscure that it is disputed whether he ever advocated any form of vegetarianism at all.[58] He almost certainly prohibited his followers from eating beans[58] and from wearing woolen garments.[58] Eudoxus of Cnidus, a student of Archytas and Plato, writes that "Pythagoras was distinguished by such purity and so avoided killing and killers that he not only abstained from animal foods, but even kept his distance from cooks and hunters".[58] One of the earliest known vegans was the Arab poet al-Maarri (c.973 c.1057).[a][59] Their arguments were based on health, the transmigration of souls, animal welfare, and the viewespoused by Porphyry in De Abstinentia ab Esu Animalium ("On Abstinence from Animal Food", c.268 c.270)that if humans deserve justice, then so do animals.[54]

Vegetarianism established itself as a significant movement in 19th-century England and the United States.[60] A minority of vegetarians avoided animal food entirely.[61] In 1813, the poet Percy Bysshe Shelley published A Vindication of Natural Diet, advocating "abstinence from animal food and spirituous liquors", and in 1815, William Lambe, a London physician, claimed that his "water and vegetable diet" could cure anything from tuberculosis to acne.[62] Lambe called animal food a "habitual irritation", and argued that "milk eating and flesh-eating are but branches of a common system and they must stand or fall together".[63] Sylvester Graham's meatless Graham dietmostly fruit, vegetables, water, and bread made at home with stoneground flourbecame popular as a health remedy in the 1830s in the United States.[64] Several vegan communities were established around this time. In Massachusetts, Amos Bronson Alcott, father of the novelist Louisa May Alcott, opened the Temple School in 1834 and Fruitlands in 1844,[65][j] and in England, James Pierrepont Greaves founded the Concordium, a vegan community at Alcott House on Ham Common, in 1838.[4][67]

In 1843, members of Alcott House created the British and Foreign Society for the Promotion of Humanity and Abstinence from Animal Food,[69] led by Sophia Chichester, a wealthy benefactor of Alcott House.[70] Alcott House also helped to establish the UK Vegetarian Society, which held its first meeting in 1847 in Ramsgate, Kent.[71] The Medical Times and Gazette in London reported in 1884:

There are two kinds of Vegetariansone an extreme form, the members of which eat no animal food products what-so-ever; and a less extreme sect, who do not object to eggs, milk, or fish. The Vegetarian Society... belongs to the latter more moderate division.[61]

An article in the Society's magazine, the Vegetarian Messenger, in 1851 discussed alternatives to shoe leather, which suggests the presence of vegans within the membership who rejected animal use entirely, not only in diet.[72] By the 1886 publication of Henry S. Salt's A Plea for Vegetarianism and Other Essays, he asserts that, "It is quite true that mostnot allFood Reformers admit into their diet such animal food as milk, butter, cheese, and eggs..."[73] Russell Thacher Trall's The Hygeian Home Cook-Book published in 1874 is the first known vegan cookbook in America.[74] The book contains recipes "without the employment of milk, sugar, salt, yeast, acids, alkalies, grease, or condiments of any kind."[74] An early vegan cookbook, Rupert H. Wheldon's No Animal Food: Two Essays and 100 Recipes, was published in London in 1910.[75] The consumption of milk and eggs became a battleground over the following decades. There were regular discussions about it in the Vegetarian Messenger; it appears from the correspondence pages that many opponents of veganism came from vegetarians.[8][76]

During a visit to London in 1931, Mahatma Gandhiwho had joined the Vegetarian Society's executive committee when he lived in London from 1888 to 1891gave a speech to the Society arguing that it ought to promote a meat-free diet as a matter of morality, not health.[68][77] Lacto-vegetarians acknowledged the ethical consistency of the vegan position but regarded a vegan diet as impracticable and were concerned that it might be an impediment to spreading vegetarianism if vegans found themselves unable to participate in social circles where no non-animal food was available. This became the predominant view of the Vegetarian Society, which in 1935 stated: "The lacto-vegetarians, on the whole, do not defend the practice of consuming the dairy products except on the ground of expediency."[78]

In August 1944, several members of the Vegetarian Society asked that a section of its newsletter be devoted to non-dairy vegetarianism. When the request was turned down, Donald Watson, secretary of the Leicester branch, set up a new quarterly newsletter in November 1944, priced tuppence.[7] He called it The Vegan News. He chose the word vegan himself, based on "the first three and last two letters of 'vegetarian'" because it marked, in Mr Watson's words, "the beginning and end of vegetarian",[7][80] but asked his readers if they could think of anything better than vegan to stand for "non-dairy vegetarian". They suggested allvega, neo-vegetarian, dairyban, vitan, benevore, sanivores, and beaumangeur.[7][81]

The first edition attracted more than 100 letters, including from George Bernard Shaw, who resolved to give up eggs and dairy.[8] The new Vegan Society held its first meeting in early November at the Attic Club, 144 High Holborn, London. Those in attendance were Donald Watson, Elsie B. Shrigley, Fay K. Henderson, Alfred Hy Haffenden, Paul Spencer and Bernard Drake, with Mme Pataleewa (Barbara Moore, a Russian-British engineer) observing.[82] World Vegan Day is held every 1 November to mark the founding of the Society and the month of November is considered by the Society to be World Vegan Month.[83]

The Vegan News changed its name to The Vegan in November 1945, by which time it had 500 subscribers.[84] It published recipes and a "vegan trade list" of animal-free products, such as Colgate toothpaste, Kiwi shoe polish, Dawson & Owen stationery and Gloy glue.[85] Vegan books appeared, including Vegan Recipes by Fay K. Henderson and Aids to a Vegan Diet for Children by Kathleen V. Mayo.[86]

The Vegan Society soon made clear that it rejected the use of animals for any purpose, not only in diet. In 1947, Watson wrote: "The vegan renounces it as superstitious that human life depends upon the exploitation of these creatures whose feelings are much the same as our own...".[87] From 1948, The Vegan's front page read: "Advocating living without exploitation", and in 1951, the Society published its definition of veganism as "the doctrine that man should live without exploiting animals".[87][88] In 1956, its vice-president, Leslie Cross, founded the Plantmilk Society; and in 1965, as Plantmilk Ltd and later Plamil Foods, it began production of one of the first widely distributed soy milks in the Western world.[89]

The first vegan society in the United States was founded in 1948 by Catherine Nimmo and Rubin Abramowitz in California, who distributed Watson's newsletter.[90][91] In 1960, H. Jay Dinshah founded the American Vegan Society (AVS), linking veganism to the concept of ahimsa, "non-harming" in Sanskrit.[91][92][93] According to Joanne Stepaniak, the word vegan was first published independently in 1962 by the Oxford Illustrated Dictionary, defined as "a vegetarian who eats no butter, eggs, cheese, or milk".[94]

In the 1960s and 1970s, a vegetarian food movement emerged as part of the counterculture in the United States that focused on concerns about diet, the environment, and a distrust of food producers, leading to increasing interest in organic gardening.[95][96] One of the most influential vegetarian books of that time was Frances Moore Lapp's 1971 text, Diet for a Small Planet.[97] It sold more than three million copies and suggested "getting off the top of the food chain".[98]

The following decades saw research by a group of scientists and doctors in the United States, including physicians Dean Ornish, Caldwell Esselstyn, Neal D. Barnard, John A. McDougall, Michael Greger, and biochemist T. Colin Campbell, who argued that diets based on animal fat and animal protein, such as the Western pattern diet, were detrimental to health.[99] They produced a series of books that recommend vegan or vegetarian diets, including McDougall's The McDougall Plan (1983), John Robbins's Diet for a New America (1987), which associated meat eating with environmental damage, and Dr. Dean Ornish's Program for Reversing Heart Disease (1990).[100] In 2003 two major North American dietitians' associations indicated that well-planned vegan diets were suitable for all life stages.[101] This was followed by the film Earthlings (2005), Campbell's The China Study (2005), Rory Freedman and Kim Barnouin's Skinny Bitch (2005), Jonathan Safran Foer's Eating Animals (2009), and the film Forks over Knives (2011).[102]

In the 1980s, veganism became associated with punk subculture and ideologies, particularly straight edge hardcore punk in the United States;[103] and anarcho-punk in the United Kingdom.[104] This association continues on into the 21st century, as evinced by the prominence of vegan punk events such as Fluff Fest in Europe.[105][106]

The vegan diet became increasingly mainstream in the 2010s,[43][44][107] especially in the latter half.[44][108] The Economist declared 2019 "the year of the vegan".[109] The European Parliament defined the meaning of vegan for food labels in 2010, in force as of 2015[update].[110] Chain restaurants began marking vegan items on their menus and supermarkets improved their selection of vegan processed food.[111]

The global mock-meat market increased by 18 percent between 2005 and 2010,[112] and in the United States by eight percent between 2012 and 2015, to $553 million a year.[113] The Vegetarian Butcher (De Vegetarische Slager), the first known vegetarian butcher shop, selling mock meats, opened in the Netherlands in 2010,[112][114] while America's first vegan butcher, the Herbivorous Butcher, opened in Minneapolis in 2016.[113][115] By 2016, 49% of Americans were drinking plant milk, although 91 percent still drank dairy milk.[116] In the United Kingdom, the plant milk market increased by 155 percent in two years, from 36 million litres (63 million imperial pints) in 2011 to 92 million (162 million imperial pints) in 2013.[117] There was a 185% increase in new vegan products between 2012 and 2016 in the UK.[108] In 2011, Europe's first vegan supermarkets appeared in Germany: Vegilicious in Dortmund and Veganz in Berlin.[118][119]

In 2017, veganism rose in popularity in Hong Kong and China, particularly among millennials.[120] China's vegan market is estimated to rise by more than 17% between 2015 and 2020,[120][121] which is expected to be "the fastest growth rate internationally in that period".[120] This exceeds the projected growth in the second and third fastest-growing vegan markets internationally in the same period, the United Arab Emirates (10.6%) and Australia (9.6%) respectively.[121][122] In total, as of 2016[update], the largest share of vegan consumers globally currently reside in Asia Pacific with nine percent of people following a vegan diet.[121] In 2013, the Oktoberfest in Munich traditionally a meat-heavy event offered vegan dishes for the first time in its 200-year history.[123]

Vegans do not eat beef, pork, poultry, fowl, game, animal seafood, eggs, dairy, or any other animal products. Dietary vegans might use animal products in clothing (as leather, wool, and silk), toiletries, and similar. Ethical veganism extends not only to matters of food but also to the wearing or use of animal products, and rejects the commodification of animals altogether.[20]:62 The British Vegan Society will certify a product only if it is free of animal involvement as far as possible and practical, including animal testing,[146][147][148] but "recognises that it is not always possible to make a choice that avoids the use of animals",[149] an issue that was highlighted in 2016 when it became known that the UK's newly-introduced 5 note contained tallow.[150][151]

An important concern is the case of medications, which are routinely tested on animals to ensure they are effective and safe,[152] and may also contain animal ingredients, such as lactose, gelatine, or stearates.[149] There may be no alternatives to prescribed medication or these alternatives may be unsuitable, less effective, or have more adverse side effects.[149] Experimentation with laboratory animals is also used for evaluating the safety of vaccines, food additives, cosmetics, household products, workplace chemicals, and many other substances.[153]

Philosopher Gary Steiner argues that it is not possible to be entirely vegan, because animal use and products are "deeply and imperceptibly woven into the fabric of human society".[154] Animal products in common use include albumen, allantoin, beeswax, blood, bone char, bone china, carmine, casein, castoreum, cochineal, elastin, emu oil, gelatin, honey, isinglass, keratin, lactic acid, lanolin, lard, rennet, retinol, shellac, squalene, tallow (including sodium tallowate), whey, and yellow grease. Some of these are chemical compounds that can be derived from animal products, plants, or petrochemicals. Allantoin, lactic acid, retinol, and squalene, for example, can be vegan. These products and their origins are not always included in the list of ingredients.[155] Vegetables themselves, even from organic farms, may use animal manure; "vegan" vegetables use plant compost only.[156]

Some vegans will not buy woollen jumpers, silk scarves, leather shoes, bedding that contains goose down or duck feathers, pearl jewellery, seashells, ordinary soap (usually made of animal fat), or cosmetics that contain animal products. They avoid certain vaccines; the flu vaccine, for example, is usually grown in hens' eggs, although an effective alternative, Flublok, is widely available in the United States.[157] Non-vegan items acquired before they became vegan might be donated to charity or used until worn out. Some vegan clothes, in particular leather alternatives, are made of petroleum-based products, which has triggered criticism because of the environmental damage involved in their production.[158] Tencel, also known as Lyocell, is a popular alternative for cotton. It is made by extracting cellulose fiber from trees. Its manufacture is thought to use 95% less water than cotton processing.[159]

The main difference between a vegan and vegetarian diet is that vegans exclude dairy products and eggs. Ethical vegans avoid them on the premise that their production causes animal suffering and premature death. In egg production, most male chicks are culled because they do not lay eggs.[160] To obtain milk from dairy cattle, cows are made pregnant to induce lactation; they are kept lactating for three to seven years, then slaughtered. Female calves can be separated from their mothers within 24 hours of birth, and fed milk replacer to retain the cow's milk for human consumption. Most male calves are slaughtered at birth, sent for veal production, or reared for beef.[161][162]

Vegan groups disagree about insect products.[163] Neither the Vegan Society nor the American Vegan Society considers honey, silk, and other insect products as suitable for vegans.[164][148] Some vegans believe that exploiting the labor of bees and harvesting their energy source is immoral, and that commercial beekeeping operations can harm and even kill bees.[165] Insect products can be defined much more widely, as commercial bees are used to pollinate about 100 different food crops.[163]

Due to the environmental impact of meat-based pet food[166][167] and the ethical problems it poses for vegans,[168][169] some vegans extend their philosophy to include the diets of pets.[167][170][171][172] This is particularly true for domesticated cats[173] and dogs,[174] for which vegan pet food is both available and nutritionally complete,[167][170][171] such as Vegepet. However, this practice has been met with caution and criticism,[170][175] especially toward vegan cat diets due to felids being obligate carnivores.[169][170][175] Furthermore, although nutritionally complete vegan pet diets are comparable to meat-based ones for cats and dogs,[176] as of August2015[update] many commercial vegan pet food brands do not meet the Association of American Feed Control Officials (AAFCO) regulations for nutritional adequacy.[177]

Vegan diets are based on grains and other seeds, legumes (particularly beans), fruits, vegetables, edible mushrooms, and nuts.[178]

Meatless products based on soybeans (tofu), or wheat-based seitan are sources of plant protein, commonly in the form of vegetarian sausage, mince, and veggie burgers.[179] Soy-based dishes are common in vegan diets because soy is a protein source.[180] They are consumed most often in the form of soy milk and tofu (bean curd), which is soy milk mixed with a coagulant. Tofu comes in a variety of textures, depending on water content, from firm, medium firm and extra firm for stews and stir-fries to soft or silken for salad dressings, desserts and shakes. Soy is also eaten in the form of tempeh and textured vegetable protein (TVP); also known as textured soy protein (TSP), the latter is often used in pasta sauces.[180]

Plant milkssuch as soy milk, almond milk, cashew milk, grain milks (oat milk, flax milk and rice milk), hemp milk, and coconut milkare used in place of cows' or goats' milk.[l] Soy milk provides around 7g (oz) of protein per cup (240mL or 8floz), compared with 8g (2/7oz) of protein per cup of cow's milk. Almond milk is lower in dietary energy, carbohydrates, and protein.[185] Soy milk should not be used as a replacement for breast milk for babies. Babies who are not breastfed may be fed commercial infant formula, normally based on cows' milk or soy. The latter is known as soy-based infant formula or SBIF.[186][187]

Butter and margarine can be replaced with alternate vegan products.[188] Vegan cheeses are made from seeds, such as sesame and sunflower; nuts, such as cashew,[189] pine nut, and almond;[190] and soybeans, coconut oil, nutritional yeast, tapioca,[191] and rice, among other ingredients; and can replicate the meltability of dairy cheese. Nutritional yeast is a common substitute for the taste of cheese in vegan recipes.[188] Cheese substitutes can be made at home, including from nuts, such as cashews.[189]

As of 2019 in the United States, there were numerous vegan egg substitutes available, including products used for "scrambled" eggs, cakes, cookies, and doughnuts.[192][193] Baking powder, silken (soft) tofu, mashed potato, bananas, flaxseeds, and aquafaba from chickpeas can also be used as egg substitutes.[188][193][194]

Raw veganism, combining veganism and raw foodism, excludes all animal products and food cooked above 48C (118F). A raw vegan diet includes vegetables, fruits, nuts, grain and legume sprouts, seeds, and sea vegetables. There are many variations of the diet, including fruitarianism.[195]

Proteins are composed of amino acids. Vegans obtain all their protein from plants, omnivores usually a third, and ovo-lacto vegetarians half.[196] Sources of plant protein include legumes such as soy beans (consumed as tofu, tempeh, textured vegetable protein, soy milk, and edamame), peas, peanuts, black (or pinto) beans, and chickpeas (the latter often eaten as hummus); grains such as quinoa, brown (or white) rice, corn, barley, bulgur, and wheat (the latter eaten as bread and seitan); and nuts and seeds. Combinations that contain high amounts of all the essential amino acids include rice and beans, corn and beans, and hummus and whole-wheat pita.[197]

Soy beans and quinoa are known as complete proteins because they each contain all the essential amino acids in amounts that meet or exceed human requirements.[198] Mangels et al. write that consuming the recommended dietary allowance (RDA) of protein0.8 g/kg (12gr/lb) of body weightin the form of soy will meet the biologic requirement for amino acids.[180] In 2012, the United States Department of Agriculture ruled that soy protein (tofu) may replace meat protein in the National School Lunch Program.[199]

The American Dietetic Association said in 2009 that a variety of plant foods consumed over the course of a day can provide all the essential amino acids for healthy adults, which means that protein combining in the same meal may not be necessary.[200] Mangels et al. write that there is little reason to advise vegans to increase their protein intake; but erring on the side of caution, they recommend a 25 percent increase over the RDA for adults, to 1g/kg (15gr/lb) of body weight.[201]

Vitamin B12 is a bacterial product needed for cell division, the formation and maturation of red blood cells, the synthesis of DNA, and normal nerve function. A deficiency may cause megaloblastic anaemia and neurological damage, and, if untreated, may lead to death.[38][203][m] The high content of folacin in vegetarian diets may mask the hematological symptoms of vitamin B12 deficiency, so it may go undetected until neurological signs in the late stages are evident, which can be irreversible, such as neuropsychiatric abnormalities, neuropathy, dementia and, occasionally, atrophy of optic nerves.[23][36][205] Vegans sometimes fail to obtain enough B12 from their diet because among non-fortified foods, only those of animal origin contain sufficient amounts.[36][205][n] The best source is ruminant food.[39] Vegetarians are also at risk, as are older people and those with certain medical conditions.[207][208] A 2013 study found that "vegetarians develop B12 depletion or deficiency regardless of demographic characteristics, place of residency, age, or type of vegetarian diet. Vegans should take preventive measures to ensure adequate intake of this vitamin, including regular consumption of supplements containing B12."

B12 is produced in nature only by certain bacteria and archaea; it is not made by any animal, fungus, or plant.[39][210][211] It is synthesized by some gut bacteria in humans and other animals, but humans cannot absorb the B12 made in their guts, as it is made in the colon which is too far from the small intestine, where absorption of B12 occurs.[39] Ruminants, such as cows and sheep, absorb B12 produced by bacteria in their guts.[39]

Animals store vitamin B12 in liver and muscle and some pass the vitamin into their eggs and milk; meat, liver, eggs and milk are therefore sources of B12.[212][213]

It has been suggested that nori (an edible seaweed), tempeh (a fermented soybean food), and nutritional yeast may be sources of vitamin B12.[202][p][215][q] In 2016, the Academy of Nutrition and Dietetics established that nori, fermented foods (such as tempeh), spirulina, chlorella algae, and unfortified nutritional yeast are not adequate sources of vitamin B12 and that vegans need to consume regularly fortified foods or supplements containing B12. Otherwise, vitamin B12 deficiency may develop, as has been demonstrated in case studies of vegan infants, children, and adults.[37]

Vitamin B12 is mostly manufactured by industrial fermentation of various kinds of bacteria, which make forms of cyanocobalamin, which are further processed to generate the ingredient included in supplements and fortified foods.[217][218] The Pseudomonas denitrificans strain was most commonly used as of 2017[update].[219][220] It is grown in a medium containing sucrose, yeast extract, and several metallic salts. To increase vitamin production, it is supplemented with sugar beet molasses, or, less frequently, with choline.[219] Certain brands of B12 supplements are vegan.[203]

Calcium is needed to maintain bone health and for several metabolic functions, including muscle function, vascular contraction and vasodilation, nerve transmission, intracellular signalling, and hormonal secretion. Ninety-nine percent of the body's calcium is stored in the bones and teeth.[221][222][223]:3574 High-calcium foods may include fortified plant milk, and kale, collards and raw garlic as common vegetable sources.[224]

A 2007 report based on the Oxford cohort of the European Prospective Investigation into Cancer and Nutrition, which began in 1993, suggested that vegans have an increased risk of bone fractures over meat eaters and vegetarians, likely because of lower dietary calcium intake. The study found that vegans consuming at least 525mg (8gr) of calcium daily have a risk of fractures similar to that of other groups.[r][227] A 2009 study found the bone mineral density (BMD) of vegans was 94 percent that of omnivores, but deemed the difference clinically insignificant.[228][s]

Vitamin D (calciferol) is needed for several functions, including calcium absorption, enabling mineralization of bone, and bone growth. Without it bones can become thin and brittle; together with calcium it offers protection against osteoporosis. Vitamin D is produced in the body when ultraviolet rays from the sun hit the skin; outdoor exposure is needed because UVB radiation does not penetrate glass. It is present in salmon, tuna, mackerel and cod liver oil, with small amounts in cheese, egg yolks, and beef liver, and in some mushrooms.[230]

Most vegan diets contain little or no vitamin D without fortified food. People with little sun exposure may need supplements. The extent to which sun exposure is sufficient depends on the season, time of day, cloud and smog cover, skin melanin content, and whether sunscreen is worn. According to the National Institutes of Health, most people can obtain and store sufficient vitamin D from sunlight in the spring, summer, and fall, even in the far north. They report that some researchers recommend 530 minutes of sun exposure without sunscreen between 10 am and 3 pm, at least twice a week. Tanning beds emitting 26% UVB radiation have a similar effect, though tanning is inadvisable.[230][231]

Vitamin D comes in two forms. Cholecalciferol (vitamin D3) is synthesized in the skin after exposure to the sun or consumed from food, usually from animal sources. Ergocalciferol (vitamin D2) is derived from ergosterol from UV-exposed mushrooms or yeast and is suitable for vegans. When produced industrially as supplements, vitamin D3 is typically derived from lanolin in sheep's wool. However, both provitamins and vitamins D2 and D3 have been discovered in Cladina spp. (especially Cladina rangiferina)[232] and these edible lichen are harvested in the wild for producing vegan vitamin D3.[233] Conflicting studies have suggested that the two forms of vitamin D may or may not be bioequivalent.[234] According to researchers from the Institute of Medicine, the differences between vitamins D2 and D3 do not affect metabolism, both function as prohormones, and when activated exhibit identical responses in the body.[235]

In some cases iron and the zinc status of vegans may also be of concern because of the limited bioavailability of these minerals.[34] There are concerns about the bioavailability of iron from plant foods, assumed by some researchers to be 515 percent compared to 18 percent from a nonvegetarian diet.[237] Iron-deficiency anemia is found as often in nonvegetarians as in vegetarians, though studies have shown vegetarians' iron stores to be lower.[238]

Mangels et al. write that, because of the lower bioavailability of iron from plant sources, the Food and Nutrition Board of the National Academy of Sciences established a separate RDA for vegetarians and vegans of 14mg (gr) for vegetarian men and postmenopausal women, and 33mg (gr) for premenopausal women not using oral contraceptives.[239] Supplements should be used with caution after consulting a physician, because iron can accumulate in the body and cause damage to organs. This is particularly true of anyone with hemochromatosis, a relatively common condition that can remain undiagnosed.[240]

High-iron vegan foods include soybeans, blackstrap molasses, black beans, lentils, chickpeas, spinach, tempeh, tofu, and lima beans.[241][242] Iron absorption can be enhanced by eating a source of vitamin C at the same time,[243] such as half a cup of cauliflower or five fluid ounces of orange juice. Coffee and some herbal teas can inhibit iron absorption, as can spices that contain tannins such as turmeric, coriander, chiles, and tamarind.[242]

Alpha-linolenic acid (ALA), an omega-3 fatty acid, is found in walnuts, seeds, and vegetable oils, such as canola and flaxseed oil.[244] EPA and DHA, the other primary omega-3 fatty acids, are found only in animal products and algae.[245] Iodine supplementation may be necessary for vegans in countries where salt is not typically iodized, where it is iodized at low levels, or where, as in Britain and Ireland, dairy products are relied upon for iodine delivery because of low levels in the soil.[246] Iodine can be obtained from most vegan multivitamins or regular consumption of seaweeds, such as kelp.[247]

As of 2014[update], few studies were rigorous in their comparison of omnivore, vegetarian, and vegan diets, making it difficult to discern whether health benefits attributed to veganism might also apply to vegetarian diets or diets that include moderate meat intake.

In preliminary clinical research, vegan diets lowered the risk of type 2 diabetes, high blood pressure, obesity, and ischemic heart disease.[30][31][32][33] A 2016 systematic review from observational studies of vegetarians showed reduced body mass index, total cholesterol, LDL cholesterol, and glucose levels, possibly indicating lower risk of ischemic heart disease and cancer, but having no effect on mortality, cardiovascular diseases, cerebrovascular diseases, and mortality from cancer.[248]

Eliminating all animal products may increase the risk of deficiencies of vitamins B12 and D, calcium, and omega-3 fatty acids.[34] Vitamin B12 deficiency occurs in up to 80% of vegans that do not supplement with vitamin B12.[249] Vegans might be at risk of low bone mineral density without supplements.[34][250] Lack of B12 inhibits normal function of the nervous system.[251][252]

The American Academy of Nutrition and Dietetics and Dietitians of Canada state that properly planned vegan diets are appropriate for all life stages, including pregnancy and lactation.[253] They indicate that vegetarian diets may be more common among adolescents with eating disorders, but that its adoption may serve to camouflage a disorder rather than cause one. The Australian National Health and Medical Research Council similarly recognizes a well-planned vegan diet as viable for any age,[254][255][25] as does the New Zealand Ministry of Health,[256] British National Health Service,[257] British Nutrition Foundation,[258] Dietitians Association of Australia,[259] United States Department of Agriculture,[260] Mayo Clinic,[261] Canadian Pediatric Society,[262] and Heart and Stroke Foundation of Canada.[263] The British National Health Service's Eatwell Plate allows for an entirely plant-based diet,[264] as does the United States Department of Agriculture's (USDA) MyPlate.[265][266] The USDA allows tofu to replace meat in the National School Lunch Program.[199]

The German Society for Nutrition does not recommend a vegan diet for babies, children and adolescents, or for women pregnant or breastfeeding.[29] Harvard Medical School has commented that "plant-based eating is recognized as not only nutritionally sufficient but also as a way to reduce the risk for many chronic illnesses".[27] Kaiser Permanente, the largest healthcare organization in the United States, has noted, Research shows that plant-based diets are cost-effective, low-risk interventions that may lower body mass index, blood pressure, HbA1C, and cholesterol levels. They may also reduce the number of medications needed to treat chronic diseases and lower ischemic heart disease mortality rates.[267] The American Institute for Cancer Research has stated, When focusing on specific types of vegetarian diets, the vegan diets showed protection for overall cancer incidence also.[268]

The Academy of Nutrition and Dietetics and Dietitians of Canada consider well-planned vegetarian and vegan diets "appropriate for individuals during all stages of the lifecycle, including pregnancy, lactation, infancy, childhood, and adolescence, and for athletes".[269] The German Society for Nutrition cautioned against a vegan diet for pregnant women, breastfeeding women, babies, children, and adolescents.[29] The position of the Canadian Pediatric Society is that "well-planned vegetarian and vegan diets with appropriate attention to specific nutrient components can provide a healthy alternative lifestyle at all stages of fetal, infant, child and adolescent growth. Attention should be given to nutrient intake, particularly protein, vitamins B12 and D, essential fatty acids, iron, zinc, and calcium.[262]

According to a 2015 systematic review, there is little evidence available about vegetarian and vegan diets during pregnancy, and a lack of randomized studies meant that the effects of diet could not be distinguished from confounding factors.[270] It concluded: "Within these limits, vegan-vegetarian diets may be considered safe in pregnancy, provided that attention is paid to vitamin and trace element requirements."[270] A daily source of vitamin B12 is important for pregnant and lactating vegans, as is vitamin D if there are concerns about low sun exposure.[t] A different review found that pregnant vegetarians consumed less zinc than pregnant non-vegetarians, with both groups' intake below recommended levels; however, the review found no significant difference between groups in actual zinc levels in bodily tissues, nor any effect on gestation period or birth weight.[272]

Researchers have reported cases of vitamin B12 deficiency in lactating vegetarian mothers that were linked to deficiencies and neurological disorders in their children.[273][274] A doctor or registered dietitian should be consulted about taking supplements during pregnancy.[275][276]

Vegan diets have attracted negative attention from the media because of cases of nutritional deficiencies that have come to the attention of the courts, including the death of a baby in New Zealand in 2002 due to hypocobalaminemia, i.e. vitamin B12 deficiency.[35]

Vegans replace personal care products and household cleaners containing animal products with products that are vegan, such as vegan dental floss made of bamboo fiber. Animal ingredients are ubiquitous because they are relatively inexpensive. After animals are slaughtered for meat, the leftovers are put through a rendering process and some of that material, particularly the fat, is used in toiletries.

Common animal-derived ingredients include: tallow in soap; collagen-derived glycerine, which used as a lubricant and humectant in many haircare products, moisturizers, shaving foams, soaps and toothpastes;[277] lanolin from sheep's wool is often found in lip balm and moisturizers; stearic acid is a common ingredient in face creams, shaving foam and shampoos, (as with glycerine, it can be plant-based, but is usually animal-derived); Lactic acid, an alpha-hydroxy acid derived from animal milk, is used in moisturizers; allantoin from the comfrey plant or cows' urine is found in shampoos, moisturizers and toothpaste;[277] and carmine from scale insects, such as the female cochineal, is used in food and cosmetics to produce red and pink shades;[278][279]

Animal Ingredients A to Z (2004) and Veganissimo A to Z (2013) list which ingredients might be animal-derived. The British Vegan Society's sunflower logo and PETA's bunny logo mean the product is certified vegan, which includes no animal testing. The Leaping Bunny logo signals no animal testing, but it might not be vegan.[280][281] The Vegan Society criteria for vegan certification are that the product contain no animal products, and that neither the finished item nor its ingredients have been tested on animals by, or on behalf of, the manufacturer or by anyone over whom the manufacturer has control. Its website contains a list of certified products,[147][282] as does Australia's Choose Cruelty Free (CCF).[283]

Beauty Without Cruelty, founded as a charity in 1959, was one of the earliest manufacturers and certifiers of animal-free personal care products.[284] Several international companies produce animal-free products, including clothes, shoes, fashion items, and candles.[285]

Vegans avoid clothing that incorporates silk, wool (including lambswool, shearling, cashmere, angora, mohair, and a number of other fine wools), fur, feathers, pearls, animal-derived dyes, leather, snakeskin, and any other kind of skin or animal product. Most leather clothing is made from cow skins. Vegans regard the purchase of leather, particularly from cows, as financial support for the meat industry.[286]:115 Vegans may wear clothing items and accessories made of non-animal-derived materials such as hemp, linen, cotton, canvas, polyester, artificial leather (pleather), rubber, and vinyl.[286]:16 Leather alternatives can come from materials such as cork, pia(from pineapples), and mushroom leather.[287][288]

Ethical veganism is based on opposition to speciesism, the assignment of value to individuals on the basis of species membership alone. Divisions within animal rights theory include the utilitarian, protectionist approach, which pursues improved conditions for animals. It also pertains to the rights-based abolitionism, which seeks to end human ownership of non-humans. Abolitionists argue that protectionism serves only to make the public feel that animal use can be morally unproblematic (the "happy meat" position).[20]:6263

Law professor Gary Francione, an abolitionist, argues that all sentient beings should have the right not to be treated as property, and that adopting veganism must be the baseline for anyone who believes that non-humans have intrinsic moral value.[u][20]:62 Philosopher Tom Regan, also a rights theorist, argues that animals possess value as "subjects-of-a-life", because they have beliefs, desires, memory and the ability to initiate action in pursuit of goals. The right of subjects-of-a-life not to be harmed can be overridden by other moral principles, but Regan argues that pleasure, convenience and the economic interests of farmers are not weighty enough.[290] Philosopher Peter Singer, a protectionist and utilitarian, argues that there is no moral or logical justification for failing to count animal suffering as a consequence when making decisions, and that killing animals should be rejected unless necessary for survival.[291] Despite this, he writes that "ethical thinking can be sensitive to circumstances", and that he is "not too concerned about trivial infractions".[292]

An argument proposed by Bruce Friedrich, also a protectionist, holds that strict adherence to veganism harms animals, because it focuses on personal purity, rather than encouraging people to give up whatever animal products they can.[293] For Francione, this is similar to arguing that, because human-rights abuses can never be eliminated, we should not defend human rights in situations we control. By failing to ask a server whether something contains animal products, we reinforce that the moral rights of animals are a matter of convenience, he argues. He concludes from this that the protectionist position fails on its own consequentialist terms.[20]:7273

Philosopher Val Plumwood maintained that ethical veganism is "subtly human-centred", an example of what she called "human/nature dualism" because it views humanity as separate from the rest of nature. Ethical vegans want to admit non-humans into the category that deserves special protection, rather than recognize the "ecological embeddedness" of all.[294] Plumwood wrote that animal food may be an "unnecessary evil" from the perspective of the consumer who "draws on the whole planet for nutritional needs"and she strongly opposed factory farmingbut for anyone relying on a much smaller ecosystem, it is very difficult or impossible to be vegan.[295]

Bioethicist Ben Mepham,[296] in his review of Francione and Garner's book The Animal Rights Debate: Abolition or Regulation?, concludes that "if the aim of ethics is to choose the right, or best, course of action in specific circumstances 'all things considered', it is arguable that adherence to such an absolutist agenda is simplistic and open to serious self-contradictions. Or, as Farlie puts it, with characteristic panache: 'to conclude that veganism is the "only ethical response" is to take a big leap into a very muddy pond'."[297] He cites as examples the adverse effects on animal wildlife derived from the agricultural practices necessary to sustain most vegan diets and the ethical contradiction of favoring the welfare of domesticated animals but not that of wild animals; the imbalance between the resources that are used to promote the welfare of animals as opposed to those destined to alleviate the suffering of the approximately one billion human beings who undergo malnutrition, abuse, and exploitation; the focus on attitudes and conditions in western developed countries, leaving out the rights and interests of societies whose economy, culture and, in some cases, survival rely on a symbiotic relationship with animals.[297]

David Pearce, a transhumanist philosopher, has argued that humanity has a "hedonistic imperative" to not merely avoid cruelty to animals or abolish the ownership of non-human animals, but also to redesign the global ecosystem such that wild animal suffering ceases to exist.[298] In the pursuit of abolishing suffering itself, Pearce promotes predation elimination among animals and the "cross-species global analogue of the welfare state". Fertility regulation could maintain herbivore populations at sustainable levels, "a more civilised and compassionate policy option than famine, predation, and disease".[299] The increasing number of vegans and vegetarians in the transhumanism movement has been attributed in part to Pearce's influence.[300]

A growing political philosophy that incorporates veganism as part of its revolutionary praxis is veganarchism, which seeks "total abolition" or "total liberation" for all animals, including humans. Veganarchists identify the state as unnecessary and harmful to animals, both human and non-human, and advocate for the adoption of a vegan lifestyle within a stateless society. The term was popularized in 1995 with Brian A. Dominick's pamphlet Animal Liberation and Social Revolution, described as "a vegan perspective on anarchism or an anarchist perspective on veganism".[301] Direct action is a common practice among veganarchists (and anarchists generally) with groups like the Animal Liberation Front (ALF) and Revolutionary Cells Animal Liberation Brigade (RCALB) often engaging in such activities, sometimes criminally, to further their goals.

Some vegans also embrace the philosophy of anti-natalism, as they see the two as complementary in terms of "harm reduction" to animals and the environment.[302]

The Vegan Society has noted, by extension, [veganism] promotes the development and use of animal-free alternatives for the benefit of humans.[303] Many ethical vegans and vegan organizations cite the poor working conditions of slaughterhouse workers as a reason to reject animal products.[304]

Environmental vegans focus on conservation, rejecting the use of animal products on the premise that fishing, hunting, trapping and farming, particularly factory farming, are environmentally unsustainable. In 2010, Paul Watson of the Sea Shepherd Conservation Society called pigs and chicken "major aquatic predators", because livestock eat 40 percent of the fish that are caught.[22] Since 2002[update], all Sea Shepherd ships have been vegan for environmental reasons. This specific form of veganism focuses its way of living on how to have a sustainable way of life without consuming animals.[305]

According to a 2006 United Nations Food and Agriculture Organization report, Livestock's Long Shadow, around 26% of the planet's terrestrial surface is devoted to livestock grazing.[306] The UN report also concluded that livestock farming (mostly of cows, chickens and pigs) affects the air, land, soil, water, biodiversity and climate change.[307] Livestock consumed 1,174 million tonnes of food in 2002including 7.6 million tonnes of fishmeal and 670 million tonnes of cereals, one-third of the global cereal harvest.[308] A 2017 study published in the journal Carbon Balance and Management found animal agriculture's global methane emissions are 11% higher than previous estimates based on data from the Intergovernmental Panel on Climate Change.[309] A 2018 study found that global adoption of plant-based diets would reduce agricultural land use by 76% (3.1 billion hectares, an area the size of Africa) and cut total global greenhouse gas emissions by 28% (half of this emissions reduction came from avoided emissions from animal production including methane and nitrous oxide, and half came from trees re-growing on abandoned farmland which remove carbon dioxide from the air).[310][311]

A 2010 UN report, Assessing the Environmental Impacts of Consumption and Production, argued that animal products "in general require more resources and cause higher emissions than plant-based alternatives".[313]:80 It proposed a move away from animal products to reduce environmental damage.[v][314] A 2007 Cornell University study concluded that vegetarian diets use the least land per capita, but require higher quality land than is needed to feed animals.[315] A 2015 study determined that significant biodiversity loss can be attributed to the growing demand for meat, which is a significant driver of deforestation and habitat destruction, with species-rich habitats being converted to agriculture for livestock production.[316] A 2017 study by the World Wildlife Fund found that 60% of biodiversity loss can be attributed to the vast scale of feed crop cultivation needed to rear tens of billions of farm animals, which puts an enormous strain on natural resources resulting in an extensive loss of lands and species.[317] Livestock make up 60% of the biomass of all mammals on earth, followed by humans (36%) and wild mammals (4%). As for birds, 70% are domesticated, such as poultry, whereas only 30% are wild.[318][319] In November 2017, 15,364 world scientists signed a warning to humanity calling for, among other things, "promoting dietary shifts towards mostly plant-based foods".[320] The 2019 IPBES Global Assessment Report on Biodiversity and Ecosystem Services found that industrial agriculture and overfishing are the primary drivers of the extinction crisis, with the meat and dairy industries having a substantial impact.[321][322] On August 8, 2019, the IPCC released a summary of the 2019 special report which asserted that a shift towards plant-based diets would help to mitigate and adapt to climate change.[323]

One of the leading activists and scholars of feminist animal rights is Carol J. Adams. Her premier work, The Sexual Politics of Meat: A Feminist-Vegetarian Critical Theory (1990), sparked what was to become a movement in animal rights as she noted the relationship between feminism and meat consumption. Since the release of The Sexual Politics of Meat, Adams has published several other works including essays, books, and keynote addresses. In one of her speeches, "Why feminist-vegan now?"[324]adapted from her original address at the "Minding Animals" conference in Newcastle, Australia (2009)Adams states that "the idea that there was a connection between feminism and vegetarianism came to [her] in October 1974", illustrating that the concept of feminist veganism has been around for nearly half a century. Other authors have also paralleled Adams' ideas while expanding on them. Angella Duvnjak states in "Joining the Dots: Some Reflections on Feminist-Vegan Political Practice and Choice" that she was met with opposition to the connection of feminist and veganism ideals, although the connection seemed more than obvious to her and other scholars (2011).[325] Other scholars elaborate on the connections between feminism, such as Carrie Hamilton who makes the connection to sex workers and animal reproductive rights.[326] Many other scholars of feminist vegan philosophy continue to add to the arguments that Adams, Duvnjak, and Hamilton have brought forth.

Some of the main concepts of feminist veganism is that is the connection between the violence and oppression of animals. For example, Marjorie Spiegal compares the consumption or servitude of animals for human gain to slavery.[325] Animals are purchased from a breeder, used for personal gaineither for further breeding or manual laborand then discarded, most frequently as food. This capitalist use of animals for personal gain has held strong, despite the work of animal rights activists and ecofriendly feminists.

Similar notions that suggest animalslike fish, for examplefeel less pain are brought forth today as a justification for animal cruelty.[325] The feminist side of the argument, however, suggests that there is no rationalization for treating animal lives with lesser reverence than human lives, even if the theory that animals are less capable of pain is verifiable.[citation needed]

Another connection between feminism and veganism is the parallel of violence against women or other minority members and the violence against animals. Animal rights activists closely relates animal cruelty to feminist issues. This connection is even further mirrored as animals that are used for breeding practices are compared to human trafficking victims and migrant sex workers.[326] Hamilton points out that violent "rapists sometimes exhibit behavior that seems to be patterned on the mutilation of animals" suggesting there is a trend between the violence towards rape victims and animal cruelty previously exhibited by the rapist.[326]

Another way that feminist veganism relates to feminist thoughts is through the capitalist means of the production itself. Carol J. Adams mentions Barbara Noske talking about "meat eating as the ultimate capitalist product, because it takes so much to make the product, it uses up so many resources".[327] The capitalization of resources for meat production is argued to be better used for production of other food products that have a less detrimental impact on the environment.

Streams within a number of religious traditions encourage veganism, sometimes on ethical or environmental grounds. Scholars have especially noted the growth in the twenty-first century of Jewish veganism[328] and Jain veganism.[329] Some interpretations of Christian vegetarianism,[330] Hindu vegetarianism,[331] and Buddhist vegetarianism[332] also recommend or mandate a vegan diet.

Multiple symbols have been developed to represent veganism. Several are used on consumer packaging, including the Vegan Society trademark[147] and Vegan Action logo,[280] to indicate products without animal-derived ingredients.[333][334] Various symbols may also be used by members of the vegan community to represent their identity and in the course of animal rights activism,[citation needed] such as a vegan flag.[335]

It has been estimated that in one year, a vegan will save 1,519,823 litres of water, 6,607kg of grain, 1,022 square metres of forest cover, 3,322kg of CO2, and 365 animal lives compared to the average US diet.[336] According to a 2016 study, if everyone in the United States switched to a vegan diet, by 2050 the country would save $208.2 billion in direct health-care savings, $40.5 billion in indirect health-care savings, $40.5 billion in environmental savings, and $289.1 billion in total savings. The authors also found that if the world switched to a vegan diet, by 2050 the global economy would save $684.4 billion in direct health-care savings, $382.6 billion in indirect health-care savings, $569.5 billion in environmental savings, and $1636.5 billion in total savings.[337]

Gary Francione ("Animal Welfare, Happy Meat and Veganism as the Moral Baseline", 2012): "Ethical veganism is the personal rejection of the commodity status of nonhuman animals..."[11]

Vegetarian and vegan diets may be referred to as plant-based and vegan diets as entirely plant-based.[19]

This terminology is controversial within the vegan community. While some vegan leaders, such as Karen Dawn, endorse efforts to avoid animal consumption for any reason; others, including Francione, believe that veganism must be part of an holistic ethical and political movement in order to support animal liberation. Accordingly, the latter group rejects the label "dietary vegan", referring instead to "strict vegetarians", "pure vegetarians", or followers of a "plant-based" diet.[21]

Another early use was by the editor of The Healthian, a journal published by Alcott House, in April 1942: "To tell a man, who is in the stocks for a given fault, that he cannot be so confined for such an offence, is ridiculous enough; but not more so than to tell a healthy vegetarian that his diet is very uncongenial with the wants of his nature, and contrary to reason."[49]

National Institutes of Health, 2013: "In the Oxford cohort of the European Prospective Investigation into Cancer and Nutrition, bone fracture risk was similar in meat eaters, fish eaters and vegetarians, but higher in vegans, likely due to their lower mean calcium intake."[226]

Matthew Cole, "Veganism", in Margaret Puskar-Pasewicz (ed.), Cultural Encyclopedia of Vegetarianism, ABC-Clio, 2010 (239241), 241.

John Davis, "Prototype Vegans", The Vegan, Winter 2010, 2223 (also here).

Daniel A. Dombrowski, The Philosophy of Vegetarianism, University of Massachusetts Press, 1984, 2.

Percy Bysshe Shelley, A Vindication of Natural Diet, London: F. Pitman, 1884 [1813]; William Lambe, Joel Shew, Water and Vegetable Diet, New York: Fowler's and Wells, 1854 [London, 1815].

For Ornish, Campbell, Esselstyn, Barnard, and Greger: Kathy Freston, Veganist, Weinstein Publishing, 2011. Ornish, from 21; Campbell, 41; Esselstyn, 57; Barnard, 73; Greger, 109.

American Dietetic Association (2003). "Position of the American Dietetic Association and Dietitians of Canada: Vegetarian diets". Journal of the American Dietetic Association. 103 (6): 748765. doi:10.1053/jada.2003.50142. PMID12778049.

For Esselystyn and Forks over Knives: Martin, David S. (25 November 2011). "The 'heart attack proof' diet?". CNN. Archived from the original on 12 March 2018. Retrieved 12 March 2018.

Cohen, Tova (21 July 2015). "In the land of milk and honey, Israelis turn vegan". Reuters. Tel Aviv. Archived from the original on 4 March 2018. Retrieved 4 March 2018. A study prepared for the Globes newspaper and Israel's Channel Two found 5 percent of Israelis identify as vegan and 8 percent as vegetarian while 13 percent are weighing going vegan or vegetarian. In 2010 just 2.6 percent were vegetarian or vegan.

Cheslow, Daniella (10 December 2015). "As More Israelis Go Vegan, Their Military Adjusts Its Menu". The Salt. NPR. Archived from the original on 4 March 2018. Retrieved 4 March 2018. The Israeli military, it turns out, was surprisingly eager to help. A military spokesman tells The Salt that vegans serve in all capacities, including as combat soldiers. Vegan soldiers wear wool-free berets and leather-free boots, and they get an additional stipend to supplement their food, the military says.

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Veganism - Wikipedia

Definition of veganism | The Vegan Society

Veganism is a way of living which seeks to exclude, as far as is possible and practicable, all forms of exploitation of, and cruelty to, animals for food, clothing or any other purpose.

There are many ways to embrace vegan living. Yet one thing all vegans have in common isa plant-based diet avoiding all animal foods such as meat (including fish, shellfish and insects), dairy, eggs and honey - as well as avoiding animal-derived materials, productstested on animals and placesthat use animals for entertainment.

Although the vegan diet was defined early on in The Vegan Society's beginnings in 1944, it was as late as 1949 before Leslie J Cross pointed out that the society lacked a definition of veganism. He suggested [t]he principle of the emancipation of animals from exploitation by man. This is later clarified as to seek an end to the use of animals by man for food, commodities, work, hunting, vivisection, and by all other uses involving exploitation of animal life by man.

The society was first registered as a charity in August 1964 but its assets were later transferred to a new charity when it also became a limited company in December 1979.The definition of veganism and the charitable objects of the society were amended and refined over the years.By winter 1988 this definition was in use - although the phrasing has changed slightly over the years - and remains so today:

"A philosophy and way of living which seeks to excludeas far as is possible and practicableall forms of exploitation of, and cruelty to, animals for food, clothing or any other purpose; and by extension, promotes the development and use of animal-free alternatives for the benefit of animals, humans and the environment. In dietary terms it denotes the practice of dispensing with all products derived wholly or partly from animals."

To read more on the history of veganism, see here.

A great deal - you'll soon find a whole new world of exciting foods and flavours opening up to you. A vegan diet is richly diverse and comprises all kinds of fruits, vegetables, nuts, grains, seeds, beans and pulses - all of which can be prepared in endless combinations that will ensure you're never bored. From curry to cake, pasties to pizzas, all your favourite things can be suitable for a vegan diet if they're made with plant-based ingredients. Check out our vegan recipes for ideas.

Vegans avoid exploiting animals for any purpose, with compassion being a key reason many choose a vegan lifestyle. From accessories and clothing to makeup and bathroom items, animal products and products tested on animals are found in more places than you might expect. Fortunately nowadays there are affordable and easily-sourced alternatives to just about everything. With over 30,000 products and services registered with our Vegan Trademark alone, living a vegan lifestyle has never been easier. Browse online today.

Currently all medicine in the UK must be tested on animals before it is deemed safe for human use, but please note: The Vegan Society DOES NOT recommend you avoid medication prescribed to you by your doctor - a dead vegan is no good to anyone! What you can do is ask your GP or pharmacist to provide you, if possible, with medication that does not contain animal products such as gelatine or lactose. For more information visit the website http://www.medicines.org.uk, which contains information on medicines prescribed in the UK, including ingredients lists.

If you're a medical charity supporter you may wish to check whether your chosen charity performs tests on animals. There are many charities that don't currently conduct animal tests and many vegans prefer donating to charities that actively seek alternative methods of testing.

Vegans choose not to support animal exploitation in any form and so avoid visiting zoos or aquariums, or taking part in dog or horse racing. A great alternative is visiting and supporting animal sanctuaries that provide safe and loving homes for rescued animals.

Want to find out more about the vegan lifestyle? Sign up to the free Vegan Pledge today. There are hundreds of thousands of vegans across the globe - with you, we're that much stronger.

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Definition of veganism | The Vegan Society

What Is a Vegan? What Do Vegans Eat? – thespruceeats.com

Veganism is a type of vegetarian diet that excludes meat, eggs, dairy products and all other animal-derived ingredients. Many vegans also do not eat foods that are processed using animal products, such as refined white sugar and some wines.

Vegan refers to either a person who follows this way of eatingor to the diet itself. That is, the word vegan can be an adjective used to describe a food item, as in, "This curry is vegan", or, it can be used as a noun, as in, "Vegans like cookies, too."

Although there is some debate as to whether certain foods, such as honey, fit into a vegan diet, if you are cooking for other vegans, it is best to err on the side of caution and avoid these foods.Most vegans extend the definition of veganism to go beyond just food and will also avoid the use of all personal and household products tested on animals, and avoid purchasing and using all animal-derived, non-food products, such as leather,fur, and wool. There is some debate as to whether second-hand animal products, such as a leather jacket from a thrift store, can be included in a cruelty-free vegan lifestyle or not.

This is perhaps the most common question about veganism. A vegan diet includes all grains, beans, legumes, vegetables and fruits, and the nearly infinite number of foods made by combining them.

In addition, many vegan versions of familiar foods are available, so you can eat vegan hot dogs,ice cream,cheese,non-dairy yogurt andvegan mayonnaisealong with the more familiar veggie burgersand other meat substitute products like vegan chicken recipes.Many foods are associated with veganism, such as soy milk, non-dairy milk substitutes, and tofu, but many non-vegans also enjoy tofu.You certainly don't have to like tofu in order to eat vegan.

Vegans also eat many of the same common and familiar everyday foods that everyone else does, such as a green salad, spaghetti, peanut butter sandwiches, cornbread, and chips and salsa. For example, foods such as a vegetarian burrito without cheese or sour cream would be vegan. A vegetarian Thai curry made from coconut milk is vegan. Pasta with tomato sauce or another non-meat and non-dairy sauce is vegan. Most bread is vegan as well.

Some people easily go from eating meat to vegan right away, while others struggle with their new commitment, or choose to go vegetarian first and then slowly omit eggs and dairy. There's no right or wrong way to do it, but you may want to learn about what's worked for other people. However you do it, keep your goals in mind and remember why you are choosing to adopt a vegan diet.

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What Is a Vegan? What Do Vegans Eat? - thespruceeats.com

About Veganism – Vegan Action

As with any mammal, cows produce milk only when pregnant and stop after their calves have been weaned. When a dairy cow delivers a female calf, the calf becomes a dairy cow herself, born to live in the same conditions as her mother. But when a dairy cow delivers a male calf, the calf is sold to a veal farm within days of birth, where he is tethered to a stall, deprived of food and exercise, and soon slaughtered for meat.(6)

Since it is unprofitable to keep cows alive once their milk production declines, life is only a few years longer for dairy cows, and are usually slaughtered at 5 years of age.(7)Thus, a cows normal lifespan of 25 years is cut 20 years short just to cut costs and maximize production.

On U.S. farms, an average of 7 egg-laying hens spend their entire lives in a battery cage with a floor area the size of a vinyl record cover.(3)

Living on wire floors that deform their feet, in cages so tiny they cannot stretch their wings, and covered with excrement from cages above them,

these chickens suffer lameness, bone disease, and obsessive pecking, which is curbed by searing the beaks off young chicks.(4)

Although chickens can live up to fifteen years, they are usually slaughtered when their egg production rates decline after two years. Hatcheries have no use for male chicks, so they are killed by suffocation, decapitation, gassing or crushing.(5)

Todays farms are not like the ones most of us learned about in school; they are mechanized factories where an animals welfare is of little concern compared to profit. Veganism emerges as the lifestyle most consistent with the philosophy that animals are not ours to use.

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About Veganism - Vegan Action

veganism.com

People sometimes express concern about whether or not a vegan diet is healthy. It has now been studied over many decades and the consensus is overwhelming: a vegan diet can not only be healthful for most people, but can also reduce the risk of some of the most dreaded diseases such as cardiovascular disease and cancer.

In 2009, the American Dietetic Association, now the Academy of Nutrition and Dietetics, issued a position paper on vegetarian diets stating that

It is the position of the American Dietetic Association that appropriately planned vegetarian diets, including total vegetarian or vegan diets, are healthful, nutritionally adequate, and may provide health benefits in the prevention and treatment of certain diseases. Well-planned vegetarian diets are appropriate for individuals during all stages of the life cycle, including pregnancy, lactation, infancy, childhood, and adolescence, and for athletes.

Kaiser Permanente, the largest HMO in the United States, is now recommending that people follow a plant-based diet.

The United States Department of Agriculture (USDA)has guidelines for vegan diets on p. 82 of theirDietary Guidelines for Americans. They also have an extensive list of nutrition resources.

Other organizations from around the world have affirmed that vegan diets are healthy:

The Mayo Clinic

Dietitians of Canada

The British National Health Service

The British Nutrition Foundation

The Dietitians Association of Australia

The National Health and Medical Research Council in Australia

What about all the claims you hear about the unnaturalness of vegan diets, deficiencies in vegan diets, and the lack of wholesome cholesterol?

It seems strange to call a vegan diet unnatural and a diet based on factory-farmed animals natural. More importantly, just because something is natural does not mean it is ethical or optimal for health. Humans are omnivores, which means that we can eat animal products, but we dont have to. So with all the evidence about the healthfulness of vegan diets, why harm nonhuman animals when we dont have to?

Vegans are vulnerable to deficiencies in vitamins B12 and D, omega-3 fatty acids, and calcium. But they have higher levels of vitamin B1, folate, vitamins C and E, and magnesium. Vegans need to supplement B12 because there is no reliable source in their diet. But B12 and D deficiencies are common in everyone, not just vegans, and doctors recommend supplementation for older people with all diets because our ability to assimilate vitamins weakens as we age.

Everyone needs to eat a well-planned diet. A well-planned vegan diet includes legumes (beans, lentils, peas, and peanuts), vegetables, fruit, whole grains, seeds, and nuts.

What about the claims floating around that we need plenty of wholesome cholesterol and saturated fat to be healthy? These have been debunked, but theyarent entirely based on wishful thinking. Because of individual variations in cholesterol levels, observational studies do not show a correlation between diets high in saturated fat and cholesterol and heart disease. The biggest, most carefully produced meta-analysis in the world will fail to show a correlation from observational studies. Dietary change studies are needed to provide the evidence. Another major problem is related to the sick population concept if everyone is already at high risk, small changes will make little difference. Studies that purport to show that lower cholesterol levels dont reduce these risks are flawed because the amount of cholesterol is too high in both the high cholesterol group and the low cholesterol group.

Ready to go vegan but not sure where to start? Try Going Vegan: Where to Start

Try some easy recipes.

Want something fancier? Try Vegan Dads blog , or try some recipes from the Shannons, who veganized the Betty Crocker Cookbook.

To learn more about veganism, which is more than a diet, see What is veganism?

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Testosterone Replacement Therapy Studies 2019

2018 saw a plethora of reports on testosterone replacement therapy, health risks, studies, trials, and types of TRT. Here at HGH doctor, our hormone replacement physicians keep up on the latest research to ensure we provide the best quality care to our clients. Part of our focus is passing new information and studies forward to you here on our website.

The results of one study on middle-aged and older men focused on the best type of treatment for fat-free mass (FFM) and muscle strength response. Men participating in the study received either intramuscular testosterone injections, transdermal TRT, or a placebo.

Although all forms of testosterone therapy showed positive improvements in FFM, total body strength, and lower and upper extremity strength, the changes seen were 3 to 5 times greater in the men who received testosterone injections rather than transdermal TRT. [1]

Testosterone therapy studies such as this one help our doctors choose the appropriate treatment for each person.

The Testosterone Therapy Trials in elderly men consisted of seven coordinated trials looking at the following areas:

We will report on these, as well as other trials and studies in this article.

Testosterone studies shed light on the benefits and safety of using testosterone replacement therapy.

For years, doctors steered men with or at greater risk of developing prostate cancer away from TRT. Even if a male had all the signs of low testosterone, many doctors believed that treatment with testosterone therapy would increase prostate cancer dangers. Luckily, there has been much research done in this area, showing the safety and benefits of TRT following prostate cancer treatment. Also, men who suffer from prostate enlargement or prostate cancer risks can also safely use testosterone therapy.

In the most recent testosterone replacement therapy studies, mounting evidence points to the safety of testosterone without reducing the risk of prostate cancer.

In a pooled analysis of 18 testosterone replacement therapy recent studies on 3,886 men diagnosed with prostate cancer, and 6,439 in the control group, there was no association between testosterone levels, DHT, and prostate cancer. [2, 3]

In a 2017 report, the Registry of Hypogonadism in Men reported that there was no increase in the odds of developing prostate cancer with the use of TRT. [4]

A 2013 study of men who underwent prostatectomy for prostate cancer found no increased risk of prostate cancer following testosterone therapy. [5]

In 2015, a study of men who underwent radiation therapy for prostate cancer followed up by testosterone therapy showed only a minor increase in serum PSA and a low rate of biochemical recurrence. [6]

Based on the current research, testosterone replacement therapy shows positive benefits for improving quality of life and well-being in men treated for prostate cancer.

With a multitude of testosterone replacement therapy studies reversing the prior concerns about cardiovascular risk, many men can improve their quality of life with TRT to treat the symptoms of hypogonadism.

Testosterone supports heart health through the production of red blood cells needed for circulation. Additionally, testosterone improves nitric oxide production crucial for proper insulin function and blood flow.

Nitric oxide is crucial to heart health and is made by the endothelium the lining of the blood vessels. Testosterone helps to lower LDL cholesterol to reduce the plaque clogging the arteries.

In 2017, a look at testosterone and the heart showed that low levels of testosterone might increase risk factors for metabolic syndrome, coronary artery disease (CAD), and type 2 diabetes. Testosterone replacement therapy helps to improve myocardial ischemia in males diagnosed with CAD. TRT also increases exercise capacity in men with congestive heart failure (CHF). Testosterone aids in weight loss and improving serum glucose levels and insulin resistance. This study reports that TRT reduces the risk of mortality in testosterone deficient men. [8]

Testosterone has many benefits for heart health, improving circulation, and reducing the risk of cardiovascular disease.

The study duration of one year consisted of receiving either testosterone gel or a placebo. Three different questionnaires every three months assessed sexual function. Results of the study showed that TRT had significant improvements for 10 out of 12 measures of sexual activity. [9, 10]

Testosterone replacement therapy studies for men with urinary symptoms such as urinary frequency, weak stream, urgency, straining to void, and other issues have found that benign prostatic hyperplasia (BPH) can impact urinary health. Prostate enlargement often occurs as men age, along with a decline in testosterone levels. Urinary issues can impact not only quality of life, but also overall health. Treatment with testosterone therapy has been shown to decrease nocturia (nighttime voiding) and improve urinary symptoms. [11]

A 2017 study of more than 650 men showed that testosterone therapy reduces weak urinary stream, nighttime waking to urinate, incomplete emptying of the bladder, and frequent urination. Additional benefits were found in erectile functions and quality of life. [12]

Testosterone has benefits for improved sexual functions as well as urinary health.

Reviewing testosterone replacement therapy studies allows our doctors to incorporate the latest research into patient treatment protocols. Low testosterone is frequently associated with the following medical conditions:

In the Physical Function Trial for men with hypogonadism, the focus was on walking distance as a measurement of testosterone benefits. TRT increased the fraction of distance walked, and the absolute increase in distance walked in 6 minutes.[13]

The Vitality Trial measured only the Functional Assessment of Chronic Illness Therapy fatigue scale, and while the results were not significant, the overall findings from the entire testosterone trials whose positive improvements on vitality, mood, and depression symptoms. However, a 2018 report found that testosterone replacement therapy reduces depressive symptoms except in individuals with major depressive disorder.[14]

The results of the Anemia Trials from these studies on testosterone therapy were extremely positive. In both men with explained and unexplained anemia, there was a considerable increase in hemoglobin concentration. The increase was associated with a significant change in the impression of vitality and general health in these men.

The Bone Trial purpose was to determine if TRT in older men could increase volumetric bone mineral density (vBMD) and bone strength. The outcome showed a total increase in vBMD of the trabecular bone in the spine as well as the whole bone vBMD. Hip strength also improved with TRT. Treatment with testosterone therapy could result in reduced risk of bone fractures for older men.

A surprising outcome of the Testosterone Therapy Trials is that there was not much in the way of cognitive benefits. However, other studies offer different findings. A double-blind, placebo-controlled study found modest improvement in global cognition.[15]

Testosterone replacement therapy can benefit physical ability, red blood cell production, and bone density.

Based on the many testosterone replacement therapy studies available for review today, we believe that the safe and supervised use of TRT can offer many benefits for middle-aged and older men. The key factor here is the need to engage in proper diagnostic testing for low testosterone and remain under doctor-supervision while receiving testosterone therapy.

To date, there is less research on testosterone therapy for women with Low T. A 2014 review of 20 randomized, placebo-controlled trials shows positive benefits for sexual response, sexual desire, frequency of activity, and overall satisfaction and orgasm. The majority of research does not show a connection between testosterone and breast cancer, making TRT a possible menopausal treatment for women who cannot use estrogen therapy. [16]

A 2015 report discusses the possible cardiovascular effects of testosterone for women, as well as enhancements for cognitive performance and musculoskeletal health in postmenopausal women. [17]

Regarding future testosterone therapy studies, 2019 should also be a promising year. HGH Doctor looks forward to keeping you informed of the latest research. At this time, we believe testosterone therapy to be extremely safe for men and women following proper diagnostic procedures.

For more information on testosterone replacement therapy, please contact our hormone clinic for a free and confidential consultation.

Research has shown testosterone replacement therapy to be extremely safe and highly effective for treating symptoms of Low T.

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Testosterone Replacement Therapy Studies 2019

Challenges and strategies in anti-cancer nanomedicine …

JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page.Abstract

Successfully translating anti-cancer nanomedicines from pre-clinical proof of concept to demonstration of therapeutic value in the clinic is challenging. Having made significant advances with drug delivery technologies, we must learn from other areas of oncology drug development, where patient stratification and target-driven design have improved patient outcomes. We should evolve our nanomedicine development strategies to build the patient and disease into the line of sight from the outset. The success of small molecule targeted therapies has been significantly improved by employing a specific decision-making framework, such as AstraZeneca's 5R principle: right target/efficacy, right tissue/exposure, right safety, right patient, and right commercial potential. With appropriate investment and collaboration to generate a platform of evidence supporting the end clinical application, a similar framework can be established for enhancing nanomedicine translation and performance. Building informative data packages to answer these questions requires the following: (I) an improved understanding of the heterogeneity of clinical cancers and of the biological factors influencing the behaviour of nanomedicines in patient tumours; (II) a transition from formulation-driven research to disease-driven development; (III) the implementation of more relevant animal models and testing protocols; and (IV) the pre-selection of the patients most likely to respond to nanomedicine therapies. These challenges must be overcome to improve (the cost-effectiveness of) nanomedicine development and translation, and they are key to establishing superior therapies for patients.

Nanomedicine

EPR effect

Clinical translation

Pre-clinical models

Industry

Companion diagnostics

Patient pre-selection

Recommended articlesCiting articles (0)

2016 The Author(s). Published by Elsevier B.V.

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Testosterone Replacement & Potassium | Healthfully

Potassium and testosterone levels play a key role in how your body develops. Low testosterone levels could lead to testosterone replacement therapy. These treatments may benefit you, but care should be taken to evaluate lab results for other abnormalities. According to the Cleveland Clinic, these may include a change in potassium levels, red blood cells, cholesterol concentrations, or a decrease in sperm count.

Male sexual characteristics are dependent upon the production of testosterone from the testicles. Muscle bulk and bone density are features that are influenced by the amount of testosterone. According to the Cleveland Clinic, testosterone is also important in keeping a sense of well being. If you have a low sense of well-being, lethargy, low libido, erectile dysfunction, or are feeling depressed, you may be having symptoms of low testosterone. If this is true, you may benefit from testosterone replacement therapy.

Testosterone replacement therapy can be prescribed by your doctor after he has confirmed your low testosterone levels. The testosterone hormone can be given by intramuscular injections, body or scrotum patches, and also in a gel form that can be rubbed into the body. Your doctor will know which therapy treatment would be best for you. The Testosterone Report states that care should be taken if you are using the patches or gels to assure that your partner or another individual does not come into contact with the product. This could cause an increase in testosterone levels and create unwanted side effects.

Potassium helps with the conduction of electricity throughout your body. This electrolyte functionality is crucial in helping the muscles in your heart and body to contract, according to the University of Maryland Medical Center. It is important to have the correct amount of potassium in your blood levels to ensure that your cells function correctly. If you are having testosterone therapy treatments, you need to know that your potassium levels may be affected.

In a study published by "Neurology," individuals were given a 10 to 13 week testosterone therapy treatment with weekly injections of testosterone. That study showed that at the end of the treatments, their potassium levels rose by 16 percent. One of the side effects of testosterone therapy treatment is the retention of potassium. Due to this increase, you should discuss with your doctor whether you should avoid high potassium foods or if any medication changes are needed.

Although there is a link to higher potassium levels with testosterone replacement therapy, more studies are needed to determine the significance of these findings. Your doctor will be able to decide if the risk of a high potassium level outweighs the risk of low testosterone. With lab tests and medications, your doctor should be able to keep a good balance between the two.

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Testosterone Replacement & Potassium | Healthfully

Transhumanism and the Image of God – InterVarsity Press

"Jacob Shatzer deepens our understanding and practice of Christianity by showing us how profound and perilous the influence of technology is on how we think and conduct ourselves today. Shatzer gives us a calm and comprehensive account of how the intellectual community is responding to these transformative forces, both the observers who are enchanted with the lures of technology and the critics who help us see what is at stake. Most important, Shatzer concludes with consolations that are well founded and inspire confidence."

Albert Borgmann, author of Real American Ethics

"Jacob Shatzer's book is a superb guide for the Christian disciple who seeks to be faithful to Christ in a technology-dominant society. It is engagingly written, highly accessible, wide-ranging in its scope, and immensely practical in its application. I am pleased to recommend this thoughtful, importantindeed, essentialwork."

Paul Copan, Pledger Family Chair of Philosophy and Ethics, Palm Beach Atlantic University, coauthor of Introduction to Biblical Ethics: Walking in the Way of Wisdom

"Jacob Shatzer demonstrates serious Christian thinking while wrestling with the seemingly overwhelming issues associated with technology and its effect on our world. Moreover, Shatzer probes the questions of how these ever-expanding technologies are influencing us. This most insightful and helpful volume raises important issues for readers about what it means to be human, what it means to be created in the image of God, what it means to function in space and time, what it means to be human in relationship with others, what it means to live in genuine community, and what all of this means for Christian theology, ethics, worship, discipleship, and the practice of authentic fellowship. Shatzer challenges readers to reflect on how technology has changed us and how it continues to change us, recognizing that technology has both drawn us away from aspects of our past while opening up new opportunities for the days ahead. This carefully researched and well-written book calls for and deserves thoughtful engagement and reflection. I heartily recommend Transhumanism and the Image of God and congratulate Professor Shatzer on this fine work."

David S. Dockery, president, Trinity International University/Trinity Evangelical Divinity School

"During the remainder of this century we will increasingly have the potential to alter the future, not just of individuals, but of the entire human species. Genetic augmentation, artificial intelligence, robotics, and other technologies will either serve a truly human future or human beings will serve those technologies. According to many tranhumanists, we are transitional humans on our way to becoming posthuman. So transhumanism offers a vision of a future in which we have the freedom to escape our humanity altogether. Jacob Shatzera new and refreshing voice in the conversationprovides cogent analyses of the transhumanist impulse and important practical strategies for preserving our humanity against the so-called technological imperative. Nothing less than our very humanity is at stake."

C. Ben Mitchell, Graves Professor of Moral Philosophy, Union University

"The adage that 'we shape our tools, and thereafter our tools shape us' takes on a new meaning with transhumanism. In this timely book, Shatzer explores how the liturgies of certain technologies can nudge us unwittingly toward a transhuman future and recommends practices that remind us what it truly means to be human."

Derek C. Schuurman, professor of computer science, Calvin College, author of Shaping a Digital World: Faith, Culture and Computer Technology

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Transhumanism and the Image of God - InterVarsity Press