Longevity and Anti-senescence Therapy Market Is Projected to Expand at A Steady CAGR Over the Forecast Period 2026 – Montana Ledger

ReportsnReports recently added a detailed overview and industry professional survey report on the global Longevity and Anti-senescence Therapy Market. In this report, titled Longevity and Anti-senescence Therapy Market Size, Share and Industry Analysis by Technologies, By Product, By Application, By Distribution Channel, and Regional Forecast 2019-2026.

The scope of the report encompasses the major types of Longevity and Anti-senescence Therapy Market that have been used, as well as the major applications being developed by industry, academic researchers and their commercialization offices, and government agencies. It analyzes current market status, examines future market drivers and presents forecasts of growth over the next five years. Technology developments, including the latest trends, are discussed. Other influential factors such as screening strategies for pharmaceuticals have also been included.

Download a FREE Sample Copy of Report at https://www.reportsnreports.com/contacts/requestsample.aspx?name=2255402

The global Longevity and Anti-senescence Therapy Market is comprehensively profiled in the report, including a detailed study of the markets key drivers and restraints, major market players, and leading segments.

Report Scope:

The scope of this report is broad and covers various therapies currently under trials in the global longevity and anti-senescence therapy market. The market estimation has been performed with consideration for revenue generation in the forecast years 2018-2023 after the expected availability of products in the market by 2023. The global longevity and anti-senescence therapy market has been segmented by the following therapies: Senolytic drug therapy, Gene therapy, Immunotherapy and Other therapies which includes stem cell-based therapies, etc.

Revenue forecasts from 2028 to 2023 are given for each therapy and application, with estimated values derived from the expected revenue generation in the first year of launch.

The report also includes a discussion of the major players performing research or the potential players across each regional longevity and anti-senescence therapy market. Further, it explains the major drivers and regional dynamics of the global longevity and anti-senescence therapy market and current trends within the industry.

The report concludes with a special focus on the vendor landscape and includes detailed profiles of the major vendors and potential entrants in the global longevity and anti-senescence therapy market.

Report Includes:

71 data tables and 40 additional tables An overview of the global longevity and anti-senescence therapy market Analyses of global market trends, with data from 2017 and 2018, and projections of compound annual growth rates (CAGRs) through 2023 Country specific data and analysis for the United States, Canada, Japan, China, India, U.K., France, Germany, Spain, Australia, Middle East and Africa Detailed description of various anti-senescence therapies, such as senolytic drug therapy, gene therapy, immunotherapy and other stem cell therapies, and their influence in slowing down aging or reverse aging process Coverage of various therapeutic drugs, devices and technologies and information on compounds used for the development of anti-ageing therapeutics A look at the clinical trials and expected launch of anti-senescence products Detailed profiles of the market leading companies and potential entrants in the global longevity and anti-senescence therapy market, including AgeX Therapeutics, CohBar Inc., PowerVision Inc., T.A. Sciences and Unity BiotechnologySummary:

Global longevity and anti-senescence therapy market deals in the adoption of different therapies and treatment options used to extend human longevity and lifespan. Human longevity is typically used to describe the length of an individuals lifetime and is sometimes used as a synonym for life expectancy in the demography. Anti-senescence is the process by which cells stop dividing irreversibly and enter a stage of permanent growth arrest, eliminating cell death. Anti-senescence therapy is used in the treatment of senescence induced through unrepaired DNA damage or other cellular stresses.

Global longevity and anti-senescence market will witness rapid growth over the forecast period (2018-2023) owing to an increasing emphasis on Stem Cell Research and an increasing demand for cell-based assays in research and development.

An increasing geriatric population across the globe and a rising awareness of antiaging products among generation Y and later generations are the major factors expected to promote the growth of global longevity and anti-senescence market. Factors such as a surging level of disposable income and increasing advancements in anti-senescence technologies are also providing traction to the global longevity and anti-senescence market growth over the forecast period (2018-2023).

According to the National Institutes of Health (NIH), the total geriatric population across the globe in 2016 was over REDACTED. By 2022, the global geriatric population (65 years and above) is anticipated to reach over REDACTED. An increasing geriatric population across the globe will generate huge growth prospectus to the market.

Senolytics, placenta stem cells and blood transfusions are some of the hot technologies picking up pace in the longevity and anti-anti-senescence market. Companies and start-ups across the globe such as Unity Biotechnology, Human Longevity Inc., Calico Life Sciences, Acorda Therapeutics, etc. are working extensively in this field for the extension of human longevity by focusing on study of genomics, microbiome, bioinformatics and stem cell therapies, etc. These factors are poised to drive market growth over the forecast period.

Global longevity and anti-senescence market is projected to rise at a CAGR of REDACTED during the forecast period of 2018 through 2023. In 2023, total revenues are expected to reach REDACTED, registering REDACTED in growth from REDACTED in 2018.

The report provides analysis based on each market segment including therapies and application. The therapies segment is further sub-segmented into Senolytic drug therapy, Gene therapy, Immunotherapy and Others. Senolytic drug therapy held the largest market revenue share of REDACTED in 2017. By 2023, total revenue from senolytic drug therapy is expected to reach REDACTED. Gene therapy segment is estimated to rise at the highest CAGR of REDACTED till 2023. The fastest growth of the gene therapy segment is due to the Large investments in genomics. For Instance; The National Human Genome Research Institute (U.S.) had a budget grant of REDACTED for REDACTED research projects in 2015, thus increasing funding to REDACTED for approximately REDACTED projects in 2016.

Any Query or Discount? Ask our Expert at https://www.reportsnreports.com/contacts/discount.aspx?name=2255402

The latest Longevity and Anti-senescence Therapy Market report provides readers with a deeper understanding of potential target consumers to create a lucrative marketing strategy for the 2019-2026 forecast period. For entrepreneurs seeking information about potential customers, it will be particularly helpful. Selective statements provided by leading vendors would allow entrepreneurs to gain a deeper understanding of the local market and prospective customers.

Table of Contents:

Chapter 1 Introduction

Study Background

Study Goals and Objectives

Reasons for Doing This Study

Scope of Report

Methodology and Information Sources

Geographic Breakdown

Market Breakdown

Analysts Credentials

.Continued

Get a 20% Discount on Direct Purchase of Longevity and Anti-senescence Therapy Market Report at https://www.reportsnreports.com/purchase.aspx?name=2255402

About Us: ReportsnReports.com is your single source for all market research needs. Our database includes 500,000+ market research reports from over 95 leading global publishers & in-depth market research studies of over 5000 micro markets.We provide 24/7 online and offline support to our customers.

E-mail: [emailprotected]

Phone: +1 888 391 5463

Read more from the original source:

Longevity and Anti-senescence Therapy Market Is Projected to Expand at A Steady CAGR Over the Forecast Period 2026 - Montana Ledger

Populists understand the power of human emotion. Europes liberals need to grasp it, too – The Guardian

The battle for 1989 was won by illiberal populism. Thats one thing we can say with certainty 30 years on from the fall of the iron curtain. In the narrative spun by Jarosaw Kaczyski, Viktor Orbn and their supporters, democratic transformation turned out to be a fraud, liberal democracy an illusion, and integration with the EU an upmarket form of foreign occupation. The illiberal populists, under the cover of such rhetoric, simultaneously dismantle the rule of law and independent institutions. Meanwhile, liberals seem devoid of ideas or initiative, agreeing only that somehow, it all went wrong.

This is not just about melancholy and misunderstanding. In a sense, post-communist countries became a testing ground after 1989. Both our families came from Warsaw and they struggled not only to survive the upheavals of that era, but to create better lives, if not for themselves, at least for their children. Individually, some succeeded, but it came at a high price. The revolutions of 1989 meant the almost overnight disintegration of entire ways of life. That had an immense impact, even if most people would not have wanted to hang on to their experience of pure socialism.

Todays populists tend to focus only on the downsides of what came after 1989. But how have they been so effective at imposing their interpretation of events, even now, 30 years on?

In the last year of the cold war, the west of our collective imagination was a place of hope Moscow we were more familiar with, and viewed with fear. Yet, contrary to the image often conveyed, the reaction in our countries to the end of communism was far from euphoric.

The promise of freedom and a better life lay on the distant horizon. Day to day, though, we experienced a poverty more humiliating than anything that had come before especially after seeing the west with our own eyes. It is a common mistake to think that illiberal politicians in post-communist countries are popular despite these countries successes. The contrary seems more plausible: their popularity is a consequence of the success.

At a time when populist leaders are in power in other parts of the world, including the US, it may be instructive to look at the causes of illiberal populism generally.

Our focus is on an aspect of human nature that is underexplored in political analysis: namely political emotion, and in particular, the feeling of loss.

It is astonishing to us to hear people in the US, the UK, France or Italy express views so familiar to us: Our jobs are being stolen, The world is changing too much, I dont recognise my country. This is where 1989 meets 2019 at least in the populists narratives. Their pessimistic interpretation of the fall of communism is mirrored in the current over-simplifications.

The year 1989 was one of those breakthrough moments in human history whose impact is felt in contradictory ways. As Charles Dickens wrote about 1789 in A Tale of Two Cities, it was the best of times and the worst of times. It was a spring of hope, and a winter of despair, it was indeed the age of wisdom and the age of foolishness.

The same duality was felt elsewhere. As well as the fall of communism, 1989 marked the beginning of an era of global change and acceleration. Quality of life and longevity improved, as revolutions were occurring in technology, communication, and social mobility. There was simultaneous gain and loss.

Central and eastern Europe has registered extraordinary economic growth on almost every parameter since the end of communism. But change, when it happens so swiftly and completely, can also involve great loss for the individual. We dont just mean the disappearance of jobs or bankruptcies. We mean something much deeper. A loss that relates to the micro-world of secure long-term relationships, identity and feelings of security, so important in the classical liberalism of Adam Smith and JS Mill.

In German, there is a word that captures this disruption: schleudern, which means to spin round and round as in a washing machine. In the social sense, our world spun repeatedly as we strived for a better future. This is the context in which we can see that illiberal populists are effective not because they buy voters, or manipulate negative emotions, such as fear or rage. Their skill is to recognise and empathise with feelings of loss when liberals tactlessly disregard or ridicule them.

And it is how we can explain the reactionary aspect of populism in eastern Europe, and beyond. Brexiters won with the slogan Take back control, and Donald Trump cut through with Make America great again. Kaczyski in Poland, Bjrn Hcke in Germany and Thierry Baudet in the Netherlands all talk about protecting the traditional values of their societies (usually without being specific about what this would mean).

Liberals often feel overwhelmed by this kind of politics. A peculiar defeatism surrounds the failure of liberal democracy to deliver. Liberals also fear that pandering to emotion plays the same game as populists. They prefer to calm feelings down or just steer clear of them.

Enemies of democracy have, of course, always manipulated feelings. Yet we believe that theres a key lesson from 1989 that liberalism can learn. We need a passionate defence of liberal democracy and the liberal order. We also need to embrace the feeling of loss and translate it into something positive and enriching, into a feeling about political community.

How could this be done? The collective sense of loss we have been describing is akin to the grief that follows the death of a loved one. In bereavement our first reaction is to look back, to dwell on the loss. Reactionary populisms concentration on the negative aspects of transformation might be compared with bereavement. As humans we know that after bereavement comes the recovery phase. And this means looking to the future and building networks of friends. It requires courage, hope and compassion especially for those who think so differently that they vote for populists.

This is what the liberalism of the future could mean. It could retell the story of 1989, while doing justice to this great and complex moment. Central and eastern Europe still has an important message for the world. It is the knowledge that the greatest successes of liberal democracy, including 1989, were enabled by passionate hope.

Karolina Wigura is a historian, political editor of the Polish weekly Kultural Liberalna and a fellow at the Institute of Advanced Studies in Berlin

Jarosaw Kuisz is a historian, editor-in-chief of the Polish weekly Kultura Liberalna and a fellow at the Institute of Advanced Studies in Berlin

The rest is here:

Populists understand the power of human emotion. Europes liberals need to grasp it, too - The Guardian

The wisdom of ancient kitchens – Easy Reader News

Added on December 12, 2019Mark McDermottManhattan Beach , newsletter

Dan Buettner in the Okinawa blue zone. Photo by Dan McLain/National Geographic

National Geographic explorer Dan Buettner investigates the food and culture of those who live the longest, and comes back with recipes

by Mark McDermott

Most mornings, Cowboy Jose Bonifacio rides his horse Corazn five miles to go see two old friends. Bonifacio is known far and wide as one of the great vaqueros, or cowboys, of the Guanacaste province on the Nicoya Peninsula of Costa Rica. He began riding horses in 1921, at the age of 4. Hes 102 years old. His two friends are both over 100.

Two years ago, National Geographic explorer Dan Buettner went looking for the great cowboy, who hes known for years. Buettner has led several expeditions to the Nicoya Peninsula because it is home to some of the longest living humans on Earth, and longevity has been his area of inquiry for the last decade and a half. Hes written four books and dozens of National Geographic articles about the so-called blue zones, the five areas scattered across the planet where people live the longest. He sought out Bonifacio who is not hard to find, having lived in the same house all his 102 years for his newest book, The Blue Zones Kitchen.

Buettners intentions were simple. He wanted to share a meal with Bonifacio and his family, and take notes. Buettner has spent more time with 100-year-olds, known as centenarians, than anyone on the planet who is not 100. His research has been about the ways of life that lead to the kind of health in which people not only live a century but do so, like Bonifacio, with gusto. Hes examined everything from habits of human connection to physical activity and even the composition of the soil and water in the lands where people live longest, but all these roads lead back to the most fundamental of human activities: sharing a meal. And this is why he found himself back at Bonifacios humble dwelling in Guanacaste.

We arrive early, waiting for him in the cool shade under the 100-year-old mango trees in his courtyard, Buettner writes. He trots up on a horse wearing blue jeans, a checkered shirt, and a jaunty-angled cowboy hat. He dismounts with a bounce and welcomes us warmly with a handshake and a half toothed smile. Hes lived in the same house his whole life, now with four generations of descendants. At 100, he still recites romantic poems and professes his love of women.

Buettner has spent time with over 300 centenarians, but none cooler than the cowboy, who on this occasion asked his daughter and granddaughter to prepare a special lunch for his visitors, Buettner and famed National Geographic photographer David McLain. The lunch was served in an outdoor kitchen, centered around an oven used by the Chorotega, a tribe of corn farmers who historically were the most powerful of the Native Americans in the region.

Dinner is served in Ikaria. Photo by Dan McLain/National Geographic

They cook over a fogn, which is a Chorortega oven that dates back before the age of Christ, Buettner said in an interview. Its sort of a U-shaped adobe appliance, so to speak, with a wooden fire. So there you are, smelling roasted corn and woodsmoke and the aromaThe beans they are making tend to be more aromatic, with peppers and onions and garlic and cilantro. And its a wooden structure with slats in it, so sunlight is angling through the slats and hitting the floor in long parallel lines, but its sort of beautifully, smokily illuminated on the inside. And you are smelling the same smells that the ancient Maya were smelling in 1,000 B.C.

Lunch was chunky vegetable soup, a veggie hash with corn and onions, hearts of palms with herbs and garlic, creamy lima beans and herbs, and fried green plantains. It was accompanied by mugs of what Buettner described as shockingly refreshing horchata and citrus fresco.

The Blue Zones Kitchen, which includes recipes for each component of the lunch, was released last week and achieved a somewhat unusual feat for what is ostensibly a cookbook: it was the bestselling book in the United States across all categories. The books success shocked even Buettner.

Its surreal, he said. After years and years of these high-minded literary pursuits, I realized what people want are just pretty pictures and a great bean recipe.

The Blue Zones Kitchen isnt like any cookbook ever before published. In it, Buettner visits kitchens in each of the five blue zones: Okinawa, Japan; Ikaria, Greece; Sardinia, Italy; Yorba Linda, California (a Seventh Day Adventist community); and the Nicoya Peninsula, Costa Rica. An earlier book, The Blue Zones Solution, also included recipes, but not presented in this way, with McLains vivid photography showing the physical beauty of the people and the food of blue zones. Its pages emanate with the warmth of human conviviality.

David and I are not cookbook writers. David and I are a writing and photography team for National Geographic, Buettner said. This book is essentially a 300-page National Geographic article, centered around food and recipes. And thats how we approached it. For the recipes, I didnt just go find some other book and copy them; I sat on stools in 80, 90 and 100-year-old womens kitchens, and I watched them. I wrote down fastidiously everything they did. I estimated quantities you know, they dont use cups or teaspoons or any of that crap. I captured these recipes, which by the way will be gone in half a generation.

The recipes from Buettners notebooks were then taken to a test kitchen and proofed out for exact quantities, and now run alongside hundreds of photos taken by McLain, which are also not the typical, prettified pictures usually found in cookbooks.

Not a single picture in the book is shot in a studio, Buettner said. Its all editorial and its all with the gifted David McLain. He shot the ingredients, the setting, the people, the cooking techniques, and then the rituals around it. So its a very different book than a cookbook.

Dan Buettner in the Costa Rica blue zone. Photo by Dan McLain/National Geographic

Buettner is well-known locally because he launched the first Blue Zones Project in the Beach Cities. The projects, which now number over 50 nationwide, are public health initiatives which take the wisdom derived from Buettners studies of actual blue zones and apply lessons programmatically; locally, the Blue Zones Project is administered by the Beach Cities Health District (see last weeks Easy Reader cover story, Tripping Over Health). Buettners central insight is that healthy behavior happens not when we focus on changing behavior, but when the environment in which we live makes healthier choices easier to make.

The Blue Zones Kitchen follows this ethos. Its easy to use. Not one of its 100 recipes requires more than a handful of ingredients. It is peasant food; simple, cheap, easy, and by the way healthy.

Its organized by genres of cooking, Buettner said. There is Greek, from Ikaria; Italian, from Sardinia; Asian, in Okinawa; Latin American, Costa Rica; and American, Loma Linda. So they are easily recognizable categories of food. They are just simple. You can add cheese if you want to some of them, but the quotidian day-to-day eating in blue zones was plant-based. They ate meat, but it was a celebratory food, and I dont need to put a recipe for roasted meat in so all the recipes are plant-based. And they all have the most important ingredient, which is taste. These recipes, theyve been cooked for at least 500 years in most of these places. The reason they survived is not because people think the recipes are healthy. Its because people like them. They are tasty.

Cowboy Jose Bonifacio in Costa Rica. Photo by Dan McLain/National Geographic

Another aspect of the book that sets it apart is its beautiful array of story, science, travel, and cultural exploration. For example, in Costa Rica Buettner found what he believes might be the most perfect breakfast in the world, featuring what locals call the tres hermanas, or three sisters: corn, beans, and squash. He recalls in loving detail enjoying this breakfast in the Cooperativa Nicoya, where a dozen women begin preparation before dawn each morning and people stop by on their way to work. The meal is the locally beloved gallo pinto, rice, and beans with garlic, onions, peppers and squash, served with freshly made tortillas, a vinegar-based hot sauce called chilero, and locally grown coffee.

At 6 a.m., the first customers file in, most of them market vendors or laborers, Buettner writes. They take seats on benches at long green tables. Cooperativa waitresses, wearing simple dresses and flip-flops, serve giant cups of weak local coffee, steaming plates of the gallo pinto, and baskets of warm tortillas. As muddy ranchero music plays from a distant radio, customers fill their tortillas with beans topped with chilero hot sauce. This is arguably the most perfect food combination ever, and for some it brings forth tears of joy.

The meal is perfect because tastes great while providing everything the human body needs for sustenance. The corn tortillas are whole-grain, low glycemic (meaning more slowly digested, absorbed, and metabolized) complex carbohydrates, Buettner reports, noting that the wood ash of the stoves breaks down the corns cell walls, thus making niacin available and freeing amino acids for absorption into the body. The black beans are rich in both antioxidants and fiber, which is colon-cleansing, lowers blood pressure and regulates insulin. Combined with rice, the beans form a perfect protein; the pepper sauce that tops it all off is a probiotic (meaning good for gut health). Even the coffee is rich in antioxidants. The total cost of the breakfast was $4.23.

Buettner writes that this meal is what the poorest people in Costa Rica subsist on. His research partners found that these very people have the longest telomeres the DNA tips that mark biological age of any in Costa Rica. He says their bodies tend to be a decade younger than their age would suggest.

Its really kind of the Zen of eating, Buettner said. Its so simple. Its like great sushi. Most cuisines are additive for example, French cuisine is cream and butter and herbs. Sushi is just beautifully one ingredient. This is three ingredients. Imagine slow-cooked beans; the beans are perfect, kind of al dente, they still have their flavor, they still have the anthocyanins, which are the anti-oxidants you find in blueberries. Add a roasted whole-grain corn tortilla: all it is whole grain corn patted down and roasted. And then some roasted squash. You put the beans in a tortilla, maybe put some hot sauce on it, or in Costa Rica its chilero, and man, you do cry tears of joyIts so easy and so cheap and the stuff is good for a long time.

Buettners blend of storytelling and science is so seamless you dont really realize you are learning. Simplicity is key. Part of this is his sources. We dont live in a time when we often have access to the elders of our tribe, and their practical, well-worn advice, as most previous generations of humanity did. Buettner shared a meal with another centenarian in Costa Rica, a 106-year-old former lumberjack named Jose Guevara.

Hed actually done a good bit of thinking about his longevity and boiled it down to three secrets: Start your day with fruit, eat beans at every meal, and practice absolute honesty, Buettner writes. Words to live by, methinks.

Much of the wisdom that comes from the blue zones is essentially remedial human training: knowledge that was baked into the way people lived for eons before the disruption caused by more modern ways of living.

Its relearning what our grandparents instinctively knew, Buettner said.

Women in Ikiaria work together in the kitchen. Photo by Dan McLain/National Geographic

The links in that chain are mostly unbroken in the blue zones. Generations know each other, and cook together. Meals are shared multi-generationally, and often communally. Some of the recipes in The Blue Zones Kitchen contain varying versions, as each village or family has its own idea of how to do things. The Melis family in Sardinia (nine siblings with a combined age of 852 years) shared their version of minestrone soup, which they told Buettner theyd eaten every day of their life. Another family shared another version.

A 100-year-old cooked me Sardinian minestrone, Buettner said. The rest of her family cooked me other things and then we sat down and drank a good bit of wine, Connoneau, which is almost always an accompaniment with meals there. And then toasts ensue, and you get that sort of perfect combination of familial warmth and alcohol, and theres no better drug.

There is science underlying the warm feeling of this scene. Sardinian minestrone is a pot of healthy amino acids with all the protein a human needs for sustenance along with huge does of fiber and healthy gut bacteria. Its cruciferous vegetablesonions, cabbage, kohlrabiregulate thyroid function, a key to longevity. And even the wine, Connoneau, is particularly flavonoid-rich and brimming with antioxidants. But the biggest factor underlying long-living is the gathering itself.

I didnt set out to try to write a cookbook from the beginning. I realized, though, that the runway for people for a healthier life is often through their mouth, Buettner said. But what makes it work, what makes it stick, and what makes it last is building a meaningful social network, or social circle, around the food. And that is in an almost hormonal senseif you are eating with somebody you like, you have less cortisol interference as compared to eating on the run or eating with some sort of existential stress, and there is a love and a joy in that which I believe adds to longevity. But more important than that, if the people you are running with are also eating largely a whole-food, plant-based diet, its not a chore. You are not getting tempted by the burgers and the baby back ribs and the chips and all the other crap that people gather around.

We are, in fact, genetically hardwired for human interaction. Previous generations of humans could not have fathomed the idea of fast food or how much we eat alone. Another common trait in all blue zones kitchens is they are social places.

We tend to be genetically endowed with a propensity for things that ensure our survival, Buettner said. And humans, unlike so many other mammals that havent been as successful, are eusocial. That weve been successful because we come together as a tribe. We naturally are drawn to each other and we can take on bigger tasks together than we can by ourselves. So to all of sudden fast forward to 2019 when everybody is imploding in their devices maybe for survivability, on its surface, we dont really need other humans. But we still have that genetic yearning for it, and the meal is the natural time to give in to that. Its the natural time to socialize because you are slowing down, you are sitting down.

Research shows that people who eat socially, particularly families, eat more nutritiously than those who eat alone.

Because when you are eating by yourself, it takes about 20 minutes for the full feeling to travel through your belly to your brain, Buettner said. So if you are eating by yourself to your favorite TV show and wolfing down your dinner, theres a very good chance that you will already be full long before your stomach knows it, long before your brain knows it. Conversely, if you are sitting down with four or five friends, you are having a conversation, you are telling jokes, you are laughing, then you take a bite of food you are less likely to overeat.

The biggest piece of advice implicit in the The Blue Zones Kitchen is simply to cook. The benefits are myriad. People in the blue zones, and those who cook in general, tend to rotate between the same 10 or 12 meals. They thus have a more consistent diet, meaning their immune systems dont have to work so hard to always counter different potential threats. A worn-out immune system is one of the things that catches up with us in older age when the body can no longer fight off cancer cells, among other things.

Cook at home. You dont have to buy my book. Theres lots of other books, Buettner said. I hear all the time, Well, I dont have time to cook. And if you take a moment and you think clearly, people who are eating junk food their whole life are probably shaving a decade off their life expectancy. If you take those 10 years and average them back through the rest of your life, youve got about 2.5 hours of a day of time that you could be spending on making good food. And youll have just as many hours in your lifetime. We fail. We get misled by a certain cultural thrust that is wrong.

I think there are a lot of people out there marketing longevity. The Blue Zones kind of genre is not just about getting more, piling on more years, its about quality along the way. Its a holistic look at longevity. And the value proposition is about 14 years. The maximum average life expectancy for humans is about 93 or 94. We are getting about 80 in America right about now, so we are leaving about 13 or 14 years on the table. We could be getting those years by living a blue zone lifestyle. But if you are living with purpose, you are socializing and connecting with friends, you have that faith-based component in place and that could be going to church, it could be going to yoga you are enjoying the journey. Its not just living long. Its living well.

It is, in a sense, the oldest story in the world, and one that is increasingly being forgotten. Buettner said that all the blue zones are increasingly being encroached upon by the disease of convenience. His reporting is documenting ways of life which are disappearing.

Okinawa in 1990 was a fantastically exotic place, and now its a jungle of Pizza Huts and A&W Root Beer. Junk food, Buettner said. Theres only a few little pockets of originality left. Costa Rica theres a damn KFC as you enter the city of Nicoya. And here is this beautiful food tradition that in Nicoya anyway its been around for 5,000 years, the Mesoamerican three sisters of corn, tortilla, beans, and squash. Which are three foods that can wholly sustain you. They are being pushed out by buckets of hormones-suffused chicken and burgers. Just like when they came to America, they are incredibly alluring. They are fast and they are cheap and they are like an orgasm in your mouth when you been used to eating sort of subtle flavors.

His mind drifts frequently to a scene on the coast of Ikaria. A woman named Athina was cooking in a kitchen crowded with women.

She is about 60, and shes been cooking for 50 years, and she learned it from her grandmother who learned it from her grandmother, Buettner said. So sitting on a stool in a tiny kitchen watching her workYou can sort of see the Aegean Sea out the kitchen window and you kind of see 500 years of history unfold. Above your head, there are all these pans, and there is this wonderful cacophony of chopping and pans bubbling and pans clattering and kids running around squealing and these sort of nomadic aromas of sage and oregano and rosemary and olive oil and the pungency of roasting squash. And Im sitting there with a glass of wine, the type of wine that is produced in Ikaria, the Pranos, the same wine that Ulysses gave the cyclops to get him drunk so he could knock him offthey are still drinking that wine in IkariaIts just happiness.

Here is the original post:

The wisdom of ancient kitchens - Easy Reader News

Vince Carter becomes fifth player to appear in 1,500 NBA games – USA TODAY

USA TODAY Sports' Jeff Zillgitt breaks down his top five teams in the NBA so far this season. USA TODAY

MIAMI The Atlanta Hawks Cam Reddish wasnt alive when teammate Vince Carter played in his first NBA game in 1999. Atlantas Trae Young, Kevin Huerter and Bruno Fernando werent yet six months old when Carter scored 16 points in his NBA debut nearly 21 years ago.

Carter on Tuesday played in his 1,500th NBA game, joining John Stockton, Dirk Nowitzki, Kareem Abdul-Jabbar and Robert Parish as the only players in leaguehistory to reach that milestone.

It is a testament not only to rare longevity but his talent and ability to adjust to different roles throughout his career from lottery pick to rookie of the year to All-Star to All-NBA to reserve to veteran sage who is playing less than half the minutes he did at the peak of his NBA powers.

Basically, he was the first option, second option, third option, sixth man, seventh man, all the way down to 14th, 15th guy," Heat coach Erik Spoelstra said before the game, "and most guys are not emotionally stable enough to be able handle that and be willing to sacrifice and Vince has done that.

Im a big fan of his over the years just because when youre around all the time and I dont get to know a lot of people but I feel like Ive gotten to know him and hes a first-class human being and great pro (and) somebody who should be celebrated for his career for sure.

This is, by Carter's account, his final season.

Save for the two lockout seasons which cost him more games played Carter has played in at least 60 games in 17 of his 22 seasons.

Opinion: Raptors fans should embrace Kawhi Leonard upon his return to Toronto

Opinion: Magic's Markelle Fultz finds groove after shoulder injury nearly derailed career

I was just trying to calculate how many more games he has than the rest of our roster combined, Hawks coach Lloyd Pierce said.

Atlantas Jabari Parker, Alex Len, Evan Turner, Allen Crabbe and Chandler Parsons skew that calculation, but the point is taken. Carter has played more games than Young, Reddish, Huerter, Fernando, DeAndre Hunter and John Collins combined.

This is pretty special, Pierce said. He grew up here in the state. This is his last time playing here in Miami. Were conscious of all the last times that are coming up. Its quite an accomplishment many different teams, many different highlights, many different moments of his career, too many count, but were going to cherish and appreciate what we have this year.

Atlanta Hawks guard Vince Carter acknowledges the crowd during the first half of the game against the Miami Heat at American Airlines Arena.(Photo: Jasen Vinlove, USA TODAY Sports)

By the time this season is over, Carter, who turns 43 on Jan. 26, should pass Stockton and Nowitzki for third on the all-time games played list, trailing just Abdul-Jabbar (1,560) and Parish (1,611).

This season, Carter should pass Alex English for No. 22 on the all-time scoring list and finish among the top-20 all-time leaders in field goals.

For the tail end of his career, Carter has been a player who has provided insight to his teammates about topics on and off the court. It's rare to get an All-Star who is willing to do that in his 40s.

Id love to talk about the value off the court later. I still need the value on the court, Pierce said. I hope theres some box score accomplishments as well and he was tremendous the other night in Charlotte.

Thats the thing. Carter can still play. He had nine first-quarter points against Miami and had 17 points in 20 minutes, 25 seconds against the Hornets on Sunday.

Autoplay

Show Thumbnails

Show Captions

Read this article:

Vince Carter becomes fifth player to appear in 1,500 NBA games - USA TODAY

Commentary: Why Palomar College leadership is on the right track – The San Diego Union-Tribune

For nearly 70 years, Palomar College Community College located in San Marcos, has provided transformational education and career opportunities to students of diverse experiences, needs, and abilities. Our commitment is to our students. We remain focused on their success. We are training the workforce of the future and in this lies our focus.

Upon my appointment to the position of superintendent/president of the Palomar Community College District in June 2016, the Governing Board established explicit goals for me. My board-given mandate was to increase enrollment, address diversity among faculty, work with the Palomar College Foundation to enhance fundraising efforts, and most importantly improve the fiscal health of the college.

The transformational changes my team has instituted to meet these goals are intended to end deficit spending and safeguard the longevity of our institution. These changes are disruptive and difficult, and have led many faculty and staff at Palomar College to call for my resignation. While I understand their anxiety and anger over my decision-making, I will never be pressured out of policies and governance structures that enable us to better serve our students.

Over the past three-plus years, we have taken a forensic look at long-standing obstacles that have prevented the college from attaining fiscal stability. It is not unusual during this type of endeavor that angst ensues.

We have had to examine the costs associated in providing full health benefits to all employees and their families. We have scrutinized our course scheduling and faculty assignments to ensure our human and fiscal resources align with the new student-centered funding formula mandated by the Board of Governors of the California Community College System. These evaluative exercises are not complete and there is much work left to do in order to secure the fiscal stability of the college. I am committed to establishing long-term financial stability for the college. We must do so in order to effectively serve our current and future students.

The transformational changes during my tenure do not stop there, and there is good news: We have increased our fall enrollment by 5% over the last two years. Community college enrollment growth during a healthy economy is an achievement only a few community colleges in California can celebrate. Under my teams leadership, the Palomar College instruction and enrollment teams have instituted strategies that generated these results. It is through this type of leadership that we will continue to help our students achieve the learning outcomes necessary to contribute as individuals and global citizens living responsibly, effectively, and creatively in an interdependent and ever-changing world.

We also have been fortunate to recruit new and diverse faculty. While we have more work to do in this area, research indicates that student success is much more likely if students are able to see themselves in their professors and that students learn in environments in which they feel connected, welcomed and engaged. As a federally recognized Hispanic-serving institution, the need to increase the diversity of our faculty is at the forefront of our ongoing and intentional hiring practices.

And finally, we are immensely proud of the work of our Palomar College Foundation. We have hired new leadership, and worked with the strong and focused Foundation Board of Directors. In the past year, the foundation generated its highest annual revenue in foundation history, awarded over $600,000 in scholarships and textbook assistance, and launched a new and more beneficial fundraising event strategy.

Since we know that many of our students face non-academic obstacles that impede student success, in 2018 we opened a new food and nutrition center on campus. Within the nine months of opening, the Anita and Stan Maag Food and Nutrition Center impacted over 3,000 households, providing over 40,400 pounds of food to students, staff and faculty facing food insecurity. While I am superintendent/president at Palomar Community College District, we will continue to focus on eliminating the non-academic obstacles that impede the success of our students.

For as long as I serve, these intentional transformational changes will continue until Palomar College is financially sustainable, our faculty and staff reflect the diversity of our students, and our foundation is able to support all students who need it.

Unapologetically, this mandate is my mantra. Despite the outrage and hostility thrust upon me by those who do not share my students-first focus and financial goals, I am confident in the bright, sustainable future we are working toward. The transformational journey is long and difficult; our students are worth it and it is an honor to serve them.

Blake is superintendent/president of Palomar College.

Continued here:

Commentary: Why Palomar College leadership is on the right track - The San Diego Union-Tribune

Should you recline on an airplane? The perennial seat debate, explained. – Vox.com

It takes roughly 15 minutes for a plane to reach its cruising altitude, which means that theres a brief, uncertain period during each flight where Im left wondering: Is the person in front of me going to recline their seat?

Usually they are, and theres nothing I can do about it, unless I want to risk diverting my flight by literally fighting them. (Over the course of one week in August 2014, three different flights were diverted because fights broke out over a reclining seat.)

I am among the camp of fliers who never recline; when it comes to short domestic flights, reclining doesnt provide a major difference in comfort for me. Still, plenty of debates have raged over fliers right to recline, since people are fervently defensive of their personal space and rights as passengers. It seems to be a never-ending cultural argument, during a time when more Americans are flying and airplane seats are the smallest theyve ever been.

Even newsrooms are split. Former New York Times business columnist Josh Barro argued in 2014, When I fly, I recline. I dont feel guilty about it. And Im going to keep doing it, unless you pay me to stop.

Damon Darlin Barros colleague at the time, who was as horrified by his opinion as I was published an opposing article in favor of the Knee Defender, a nifty device (banned by some airlines) that prevents the person in front of you from reclining.

The previous year, Slates Dan Kois wrote that people who tilt their seats back are pure evil after he unsuccessfully asked the woman in front of him to partially un-recline her seat. The issue is still being debated now years later on Twitter, where people notoriously air out their travel woes.

Your discomfort isnt entirely the fault of your fellow economy passengers, although theyre an easy target for quiet rage. Its more the fault of the American aviation industry at large, which condemns us to crowded planes with limited legroom and high fares.

Plane seats have shrunk considerably over the past few decades as airlines attempt to accommodate a record number of fliers by maximizing space within an aircraft.

Airlines are a business, Debbie Carstens, a Florida Tech professor of aviation with a background in human-factors engineering, wrote to me in an email. As much as airline companies value their customers experience, profits are vital to a companys longevity.

In a 2014 column for USA Today, travel writer Bill McGee dug through decades-old reports of airline seat size and compared them to todays standards. (His analysis primarily applies to major airlines since budget carriers typically offer smaller seats that might not recline at all.) He found that American, Delta, and United Airlines offer in some aircrafts a seat pitch, or the distance between rows of seats, of only 30 inches in economy.

In years past, 31 or 32 inches were the absolute minimums. Whats more, the roomiest pitch offered by the Big Three and Southwest (31-33 inches) are now tighter than they were at all four carriers in recent years, by anywhere from 2 to 5 inches.

Economy seats are also a few inches narrower than they were in the 1990s, which is exacerbated by the fact that Americans are physically wider than they were two decades ago. The narrowest seats today are about 17 inches wide two inches tighter than what were considered narrow in the 1990s, according to McGee.

On most domestic flights served by American, United, or Southwest, coach passengers are limited to a 2-inch recline. This year, Delta is testing a two-inch reduction on seat recline for one of its new fleets a move that the airline claims will improve personal space (Delta is not adding seats or reducing legroom).

Besides size, some design experts say airplane seats are not well-designed for human bodies, which explains why theyre so uncomfortable. Think of an economy seat as a shirt thats designed to be one-size-fits-all.

People with larger bodies than average are uniquely susceptible to strict airline policies, which could require passengers who dont fit comfortably within their seat to purchase a second one. If a traveler doesnt purchase accommodations ahead of time, theres no guarantee an airline will let them fly if they dont fit in their seat. There are also passengers with physical conditions who need to recline their seats for additional comfort, no matter how short the flight is.

Consumer groups have publicly voiced complaints about shrinking seats and crowded aircrafts to the Federal Aviation Agency. Under the FAA Reauthorization Act of 2018, the agency is expected to issue regulations that establish minimum dimensions for seat pitch, width, and length. The FAA is currently conducting a study with more than 700 participants for these standard dimensions, which lawmakers have criticized for its slow-moving pace.

Small seats have been the industry standard for decades now and thats not likely to change, even with the upcoming FAA rules. Seat recliners (and those who despise them) arent likely to change their habits either.

It seems the only thing we can do is perennially argue about it, because, in the grand scheme of things, were powerless against the aviation industry. So what are you supposed to do the next time you board? I consulted Myka Meier, an etiquette expert and author of Modern Etiquette Made Easy. Everyone has a right to recline, she said, but its about timing. Having a seat recline unexpectedly can be off-putting, especially if a person wants to have a drink or enjoy a meal.

Regardless of whether your discomfort is the fault of the airlines or your fellow humans, Meier encourages passengers to be thoughtful and courteous in interactions with neighbors to reduce the likelihood of mid-flight scuffles.

What I typically recommend is not necessarily asking because the person could just say no, she told me. You can just gently lean back and notify them that youre about to recline.

Sign up for The Goods newsletter. Twice a week, well send you the best Goods stories exploring what we buy, why we buy it, and why it matters.

Go here to read the rest:

Should you recline on an airplane? The perennial seat debate, explained. - Vox.com

How Impact, Meaning, And Purpose Are Different (And Why You Should Care) – Forbes

Purpose. Impact. These terms are thrown around more than ever these days, including in some unexpected places, like one of the worlds largest investors annual letter. Purpose statements are printed on everyday objects and impact investing or sustainability are as likely as gross margins to be discussed over lunch in some offices.

We have yet, though, to pay as much attention to the concept of meaning, at our collective peril. This oversight is a root cause of companies and investments inadequate progress toward becoming better for the people and planet around them.

Why do we need to develop this third, perhaps apparently overlapping, concept? Without meaning, impact is neutral: defined as a marked effect or influence, by the Oxford English Dictionary. Similarly, purpose without meaning is an ambitious mission that fails to engage or motivate the people required to get it done. Purpose, impact, and meaning are closely related, but they are not synonyms or substitutes. We need all three to fulfill our human potential and build a healthier, more equitable version of capitalism.

We are living in the time of peak purpose where your dish soap or toothpaste label is as likely to have a purpose statement as a not-for-profits annual report. This is a good thing, and arguably not surprising: humans are evolutionarily predisposed to do things that contribute to some outcome larger than our own survival. And now that our careers and purchases are so intertwined with our identity, we have even higher expectations that the companies we work for and buy from to have this same sense of purpose.

We get anxious when we dont understand the larger goal that our daily efforts are advancing. Indeed, ample research has shown that identifying and pursuing a purpose improves individuals physical and mental well-being. Other studies have shown organizations to perform better (financially and in other terms) when they have a purpose AND employees are clear about what that purpose is and how they contribute to it. But none of these benefits are felt if the purpose isnt anchored by specific impacts and the meaning that they have to each individual participant.

These days, there is also a lot of talk about impact. Impact investing is all the rage these days, though many deals that claim the label dont pass muster for many experts (at least not as being markedly different from deals that have always happened) as simply good business.

Millennials have become famous for wanting measurable and immediate impact from their jobs, purchases, and donations. Theyre not the weird ones, its just that the rest of us are products of the last industrial revolution, in which we operated machines, pushed paper, or otherwise served as cogs in processes that separated us from our direct impact.

Purpose and impact at the organizational level are also having a heyday. Larry Finks annual letters pushed his portfolio CEOs a plurality of the global economy at this point to consider their organizations purpose and impact, beyond financial returns. In August 2019, 181 CEOs of large, publicly traded corporations issued a statement, revoking Milton Friedmans position that shareholder value was the primary and sole purpose of corporations.

The concept that hasnt been making headlines is meaning. This is a problem. Without meaning, impact is a neutral term: a marked effect or influence, according to the Oxford English Dictionary. Similarly, purpose without meaning is a lofty aspirational statement. And while other creatures also are driven to contribute to something larger than their own evolutionary success (ever seen an ant colony work, or eaten honey?), what is uniquely human is the meaning that we are able to ascribe to those efforts. In other words, the impacts of our actions, and what purpose they serve. So without making meaning of the impact of our actions, and why they matter in a larger sense, over time, we are not fulfilling our human potential. Were just ants building a hill.

Ants work hard and collaboratively, but without the human ability of assigning meaning to their ... [+] efforts.

Dont want to be an ant? Great, heres your playbook.

First, lets agree on definitions.

Consider your morning workout. Its impact might include releasing endorphins, strengthening your heart or muscles, burning fat, distracting you from worries about the day ahead, providing quality time with friends, exposing you to potential new friends, building your confidence to tackle other, non-physical challenges, upholding your side of a bet with a friend or group, or preparing you for a marathon or other physical feat. These are all wonderful effects, but will not matter equally to every person or even to a single individual at different times of their life. This is where it matters that we make meaning of our impact. A prescribed marathon training routine or group commitment to regular workouts are proven to have far higher persistence rates than the famous new years resolution to work out more. The stronger the sense of significance, what the workout means to you the more likely you are to perform the act, meet your goals, and unleash your potential in this area of your life.

So imagine youre someone who finds great purpose in supporting friends and family. You build a workout routine that has the impact of keeping your heart healthy and body strong. This will mean that you are around for a long time and able to play with grandchildren, nieces and nephews, biological or otherwise. You also know that in our increasingly inactive culture plagued by diabetes and heart disease, its powerful to set an example of physical fitness. The impact of setting this example has great meaning for you as part of how you advance your purpose of supporting your friends and family.

Taking the time to make these connections between the impact of your workouts to their specific meaning for you, and how that ladders up to your purpose, provides powerful motivation. You likely wouldnt be as motivated by the other impacts of your workout mentioned above, such as social contact or buffer arms.

On the other hand, the heart health and longevity that directly advance your personal purpose are way too distant and abstract for other people whove just moved to a new city and have a purpose to build a community of fellow devotees of physical activity. They would be most motivated by workouts with a social element and a group of regular participants who might become friends.

Meaning is a critical element to derive the observed benefits of living and working with purpose.

We can apply the same meaning-making process in our professional lives. Imagine that youre a supply chain manager and have taken to mentoring and now more actively sponsoring a newly hired woman on your team. You see great potential, and shes very interested in integrating circular economy principles and social responsibility into your companys approach. Over time, your support has the impact of providing this woman with formative learning experiences, advancing her career and salary, improving conditions for the factory workers in your supply chain, and extending the useful life cycle of your products.

Most of us can see the meaning of all of these impacts. But well derive more motivation and fulfillment by focusing on the ones that connect most directly to our individual sense of purpose. In other words, if you see your purpose as reducing gender inequality, focus on the two former impacts and the meaning they have to you in elevating a woman toward your companys leadership. On the other hand, if your purpose is about reducing waste, spending time thinking about the meaning of your colleagues impact extending your products life cycle.

Playing the four-year-old favorite Game of Why is a simple way to get from impact to meaning and eventually the overarching purpose of your work. Your inner dialog (or eventually conversation with a direct report) could go something like this:

A: Why are you sponsoring this female colleague?

B: So that she gets a promotion.

A: Why do you want her to get a promotion?

B: So that she has more influence on our companys future.

A: Why do you want her to have influence?

B: Because our senior leadership team isnt yet representative of the diversity of our customers gender identities.

A: Why [you get the idea by now]?

B: Because when leadership represents customers gender mix we create a company and products that are better for all stakeholders and improve the companys performance.

A: Why?

B: Because that will provide advancement, professional satisfaction, and wealth to our female colleagues as well as products that best serve our female customers needs.

A: Why?

B: Because our society functions best when all of its members reach their potential, and currently were losing out on serious potential economic growth and social innovation.

We're born to want to know 'why,' as you know if you've spent time with a four-year-old!

Just keep asking yourself why, and be curious about your answers. This simple process works amazingly well with colleagues and direct reports to help them connect the dots between their impact on your team and the meaning they do or could draw from it, and eventually the purpose that unites and motivates their work.

Its exciting to be part of this twenty-first century evolution of corporate purpose, which is leading us to a more equitable and regenerative form of capitalism. But we must both 1) ground our lofty individual and organizational purposes in action, and 2) help all employees connect the dots of their day-to-day impact to its meaning the significance it has to them personally. Without investing the time and money to learn and do this meaning-making process, we are just ants building hills. And leaders commitments in Davos, at the Business Roundtable, and in the BlackRock portfolio, will remain admirable but empty pledges.

On the other hand, when we make the time to understand and then share the current and potential impact of our work, and explore what it might mean to us each as employees, we create the motivating drive that is required to transform our economy. We have all the technology and resource to make our impact more positive. The meaning-making process is simple remember our four-year-old Game of Why. And purpose emerges organically once we are really paying attention to themes in the meaning we derive from our work, individually and collectively.

All thats required is that we believe that businesses can and should work alongside the public sector and not-for-profits to have positive impact on the planet and all people. And then remember that work can be a powerfully meaningful part of the human experience. If we make these basic shifts in belief systems (which have long been and are still held by many global communities), we are positioned for a rapid transition to the most equitable, peaceful, and healthy global society ever.

The transition to a healthier, more equitable and regenerative capitalism is within reach.

View original post here:

How Impact, Meaning, And Purpose Are Different (And Why You Should Care) - Forbes

Nanomedicine Market Size, Share Analysis by Key Manufacturers, Production Overview, Upstream Raw Materials, Recent Trends, Growth, Regional Outlook…

The Nanomedicine market was valued at XX Million US$ in 2018 and is projected to reach XX Million US$ by 2025, at a CAGR of XX% during the forecast period. In this study, 2018 has been considered as the base year and 2019 to 2025 as the forecast period to estimate the market size for Nanomedicine.

Global Nanomedicine industry market professional research 2019-2025, is a report which provides the details about industry overview, industry chain, market size (sales, revenue, and growth rate), gross margin, major manufacturers, development trends and forecast.

We, AMR after in-depth analysis has introduced a new research study on Global Nanomedicine Market Growth (Status and Outlook) 2019-2025. The global Nanomedicine market is estimated to grow with a strong CAGR during the forecast period of 2019 2025. The report provides a unique competitive analysis of the size, segmentation, competition, trends, and outlook in the manufacturers operating in the Nanomedicine market and highlights the insights strategic industry Analysis of the key factors influencing the market. The report presents an in-depth assessment of the market covering key trends, market drivers, challenges, standardization, regulatory landscape, deployment models, operator case studies, opportunities, future roadmap, value chain, ecosystem player profiles, and strategies. The report contains detailed product mapping and investigation of various market scenarios.

Research is crucial. Let the experts handle it!Avail Flat 40% off on all our qualitative research reports.Be the Santa of your Happy Business!

Get Free Sample Report @ https://www.acquiremarketresearch.com/sample-request/268227/

Top companies in the market are: GE Healthcare, Johnson & Johnson, Mallinckrodt plc, Merck & Co. Inc., Nanosphere Inc., Pfizer Inc., Sigma-Tau Pharmaceuticals Inc., Smith & Nephew PLC, Stryker Corp, Teva Pharmaceutical Industries Ltd., UCB (Union chimique belge) S.A

By the Product-Types, it primarily split into: Regenerative Medicine, In-vitro & In-vivo Diagnostics, Vaccines, Drug Delivery

By End-Users/Application, this report covers: Clinical Cardiology, Urology, Genetics, Orthopedics, Ophthalmology

Be the Santa of your Happy Business!

Drivers And Restraints:

According to the report, all the external factors that expected to contribute towards its growth are the drivers in the Nanomedicine market. The report includes data from different industries that are expected to grow and create more demand and opportunities for the products in the future. The detailing will help the reader understand the trajectory of the market for making better business decisions. The restraints in the market are all the factors that are expected to inhibit its growth in the future. The market restraints study will help readers understand the challenges the market might face in the near future. Also, it will help them take necessary measures to prevent loses. The report further highlights the opportunities present in the global Nanomedicine market.

Geographical Outlook of The Global Nanomedicine Market:

The geographic outlook of the market is provided along with an analysis of all the regions which occupy the regional shares of the market. The report provides you with all the information about the revenue generated by different regions from import, export, and manufacturing. Market segment by regions, regional analysis covers Americas (United States, Canada, Mexico, Brazil), APAC (China, Japan, Korea, Southeast Asia, India, Australia), Europe (Germany, France, UK, Italy, Russia, Spain), Middle East & Africa (Egypt, South Africa, Israel, Turkey, GCC Countries).

Access Full Report with TOC @ https://www.acquiremarketresearch.com/industry-reports/nanomedicine-market/268227/

Key Reasons To Purchase This Report:

To have a quick investigation of the market and have a thorough comprehension of the global Nanomedicine market. Analyze the creation forms, enormous scale issues, and answers for alleviating the improvement hazard. To comprehend the most influencing driving and restraining forces in the market and its impact on the global market. Find out about the marketing strategies that are being embraced by driving particular associations. To comprehend the future market viewpoint and market improvement, development factors, applications investigation and future possibilities 2025.

Major Topics Covered in this Report Chapter 1 Study CoverageChapter 2 Executive summaryChapter 3 Market Size by ManufacturersChapter 4 Production by RegionsChapter 5 Consumption by RegionsChapter 6 Market Size by TypeChapter 7 Market Size by ApplicationChapter 8 Manufacturers ProfilesChapter 9 Production ForecastsChapter 10 Consumption ForecastChapter 11 Upstream, Industry Chain and Downstream Customers AnalysisChapter 12 Opportunities & Challenges, Threat and Affecting FactorsChapter 13 Key FindingsChapter 14 Appendix

Customization of the Report: This report can be customized to meet the clients requirements. Please connect with our sales team ([emailprotected]), who will ensure that you get a report that suits your needs.

See the original post here:
Nanomedicine Market Size, Share Analysis by Key Manufacturers, Production Overview, Upstream Raw Materials, Recent Trends, Growth, Regional Outlook...

Nanomedicine Market Forecast to 2026 : How it is Going to Impact on Global Industry to Grow in Near Future – Gazette Quest

Global Nanomedicine Market is forecast to bring about a fairly desirable remuneration portfolio by the end of the forecast period 2019-2025. Certainly, the report not only includes a modest growth rate over the forecast time frame but also contains a reliable overview of this business. The study involves overall growth opportunities and valuation currently this market is holding. Additionally, the report involves classified segmentation of Nanomedicine market.

The global Nanomedicine Market report comprises a thorough outline and upcoming view. Get sample copy of Nanomedicine Market Report at https://www.stratagemmarketinsights.com/sample/9943

Some of key competitors or manufacturers included in the study are:

Regional analysis covers:

Market Scenario:

The report further highlights the development trends in the global Nanomedicine market. Factors that are driving the market growth and fueling its segments are also analyzed in the report. The report also highlights on its applications, types, deployments, components, developments of this market.

Additionally, the report quotes worldwide certainties and countenance of Nanomedicine industry along with downstream and upstream analysis of leading players. Numerous research findings and conclusions stated in the report will help decision-makers to take imperative decisions in the near future.

Ask more details or request a custom report sample to our experts at https://www.stratagemmarketinsights.com/quiry/9943

The Nanomedicine Market report is a compilation of first-hand information, qualitative and quantitative assessment by industry analysts, inputs from industry experts and industry participants across the value chain. The report provides an in-depth analysis of parent market trends, macro-economic indicators, and governing factors along with market attractiveness as per segments. The report also maps the qualitative impact of various market factors on market segments and geographies.

Nanomedicine Market report Segmented By Product Type:

Nanomedicine Market report Applications:

Chapters involved in Nanomedicine market report:

Chapter 1: Market Overview, Drivers, Restraints and Opportunities, Segmentation overviewChapter 2: Market Competition by ManufacturersChapter 3: Production by RegionsChapter 4: Consumption by RegionsChapter 5: Production, By Types, Revenue and Market share by TypesChapter 6: Consumption, By Applications, Market share (%) and Growth Rate by ApplicationsChapter 7: Complete profiling and analysis of ManufacturersChapter 8: Manufacturing cost analysis, Raw materials analysis, Region-wise manufacturing expensesChapter 9: Industrial Chain, Sourcing Strategy and Downstream BuyersChapter 10: Marketing Strategy Analysis, Distributors/TradersChapter 11: Market Effect Factors AnalysisChapter 12: Market ForecastChapter 13: Nanomedicine Research Findings and Conclusion, Appendix, methodology and data source

Hurry Up limited period offer to get discount on the report: https://www.stratagemmarketinsights.com/cart/9943

About Us:

Stratagem Market Insights is a management consulting organization providing market intelligence and consulting services worldwide. We bring the expertise of consultants with an cumulative industry experience of more than 70 years. The firm has been providing quantified B2B research and currently offers services to over 350+ customers worldwide. Our reports cover various end-use industries such as Aerospace and Defense, Agriculture, Food and Beverages, Automotive, Chemicals and Materials, Consumer Goods and Retail, Electronics, Energy, Mining, and Utilities, Pharmaceuticals, Manufacturing and Construction, Services, and Healthcare, and ICT.

Get in touch @ https://healthcareinsights786.blogspot.com/

Read more:
Nanomedicine Market Forecast to 2026 : How it is Going to Impact on Global Industry to Grow in Near Future - Gazette Quest

Researchers Find Nanotoxicity Studies May Be Affected by Nanoparticles Staying Behind in Syringes – Lexology

On November 25, 2019, the European Union (EU) Observatory for Nanomaterials (EUON) announced the publication of a study published in Frontiers in Pharmacology entitled Unpredictable Nanoparticle Retention in Commonly Used Plastic Syringes Introduces Dosage Uncertainties That May Compromise the Accuracy of Nanomedicine and Nanotoxicology Studies. The researchers in the study radiolabeled a variety of different nanoparticles, loaded suspensions of particles into different plastic syringes, and then measured the radioactivity left behind after emptying the nanoparticle suspension from the syringe. This provided a simple way to measure the fraction of nanoparticles that remained stuck inside the syringe. According to EUON, in the worst case, up to 79.1 percent of the nanoparticles remained. The study found variability in the amounts remaining behind depending on the types of particles and syringes used. The researchers propose checks to determine the correct combination of syringe and nanoparticle that should be used to minimize the problem. The study did not identify the root causes of the high variability between the different nanoparticles and syringe types used.

Go here to see the original:
Researchers Find Nanotoxicity Studies May Be Affected by Nanoparticles Staying Behind in Syringes - Lexology

Healthcare Nanotechnology (Nanomedicine) Market 2024 Trends Forecast Analysis by Manufacturers, Regions, Type and Application Revenue, Gross Margin…

Global Healthcare Nanotechnology (Nanomedicine) Market comprehensive analysis of the business models, key ways, and individual market shares of some of the most outstanding players during this landscape. AN in-depth statement on the key influencing factors, market statistics in terms of revenues, segment-wise knowledge, region-wise knowledge, and country-wise knowledge are offered within the full study. with growth trends, numerous stakeholders like investors, CEOs, traders, suppliers, analysis & media, international Manager, Director, President, SWOT analysis i.e. Strength, Weakness, Opportunities and Threat to the organization and others. This report focuses on Professional Global Healthcare Nanotechnology (Nanomedicine) Market 2020-2024 volume and value at Global level, regional level and company level.

Global Healthcare Nanotechnology (Nanomedicine) Market 2020report provides key statistics on the market status of the Healthcare Nanotechnology (Nanomedicine) Manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the Healthcare Nanotechnology (Nanomedicine) Industry. The Healthcare Nanotechnology (Nanomedicine) industry report firstly announced the Healthcare Nanotechnology (Nanomedicine) Market fundamentals: type applications and market overview; product specifications; manufacturing processes; cost structures, raw materials and so on.

Nanomedicine is a promising mode of cancer treatment. With the advantage of the properties of matter at nanoscale, nanomedicine promises to develop innovative drugs with greater efficacy and lesser side effects than standard therapies.

Healthcare Nanotechnology (Nanomedicine)market competition by top manufacturers/ Key player Profiled:

Abbott Laboratories,Combimatrix Corporation,GE Healthcare,Sigma-Tau Pharmaceuticals Inc.,Johnson and Johnson,Mallinckrodt Plc,Merck and Company Inc.,Nanosphere Inc.,Pfizer, Inc.,Celgene Corporation,.

And More

Get a Sample PDF of report @http://www.360marketupdates.com/enquiry/request-sample/13121392

Healthcare Nanotechnology (Nanomedicine) Market Segment by Type covers:

Healthcare Nanotechnology (Nanomedicine) Market Segment by Applications can be divided into:

Regional analysis covers:

Scope of theHealthcare Nanotechnology (Nanomedicine) MarketReport:

Fill the Pre-Order Enquiry form for the report @https://www.360marketupdates.com/enquiry/pre-order-enquiry/13121392

Key questions answered in the report:

Key Benefits

And More.

Look into Table of Content of Healthcare Nanotechnology (Nanomedicine) Market Report @https://www.360marketupdates.com/TOC/13121392#TOC

The next part also sheds light on the gap between supply and consumption. Apart from the mentioned information,growth rateof Healthcare Nanotechnology (Nanomedicine) market in 2025is also explained.Additionally, type wise and application wise consumptiontables andfiguresof Healthcare Nanotechnology (Nanomedicine) marketare also given.

Objective of Studies:

Buy this report (Price $ 3480 for a single-user license)@ https://www.360marketupdates.com/purchase/13121392

About 360 Market Updates:

360 Market Updates is the credible source for gaining the market research reports that will exponentially accelerate your business. We are among the leading report resellers in the business world committed towards optimizing your business. The reports we provide are based on a research that covers a magnitude of factors such as technological evolution, economic shifts and a detailed study of market segments.

CONTACT US

Mr. Ajay More

Phone:+14242530807 / + 44 20 3239 8187

Email:[emailprotected]

Insect Repellent Market 2020: Global Industry Size, Share, Future Challenges, Revenue, Demand, Industry Growth and Top Players Analysis to 2024

Press Release Distributed by The Express Wire

To view the original version on The Express Wire visit Healthcare Nanotechnology (Nanomedicine) Market 2024 Trends Forecast Analysis by Manufacturers, Regions, Type and Application Revenue, Gross Margin Forecast Analysis| 360 Market updates

See more here:
Healthcare Nanotechnology (Nanomedicine) Market 2024 Trends Forecast Analysis by Manufacturers, Regions, Type and Application Revenue, Gross Margin...

Cancer in the workplace: Innovative diagnostic devices and treatments – Bangkok Post

Cancer itself is a very broad based topic. There are various forms of cancer and many different types of diagnostics and treatments that are currently available. In our earlier articles, we have touched on various aspects of cancer:

- Key facts with statistics - Major causes- The correlation between employment and the illness- Risk reduction- Types of treatment available- Treatment cost overview- Integrative and Preventive Medicine

So far, the treatment model that is proven by several sources to have the best results is through Integrative Medicine. Its approach is to combine conventional methods with both complementary and alternative therapies. It is very patient-centred, making use of natural products, modification of lifestyle, diet, a mind-body-spirit healing journey together with conventional treatments like chemotherapy.

Dr. ChatChai Sribundit (M.D) from Akesis Life Bangkok (akesisoncology.com) emphasises the important role that integrative medicine plays in todays cancer management and in many cancer-care programs. As he mentioned in earlier articles, almost one third of cancer cases are actually preventable. Risk factors can be eliminated and implementing existing evidence-based preventive strategies are definitely the winning formula.

In the long run, preventive strategies in the form of regular exercise and maintaining a healthy weight reduces the risk not only of cancer but many other primary medical conditions. In addition, a well-balanced lifestyle and healthy food provide both long and short term benefits. Apart from the above, Dr. Chatchai stands firmly by his 5 pillars consisting of medical intervention, diet & nutrition, physical therapy & exercise, emotional wellness and patient education.

Together with the basis of the 5 Pillars, early detection with timely and proper patient management can greatly reduce cancer risk. Many cancers have a high chance of cure if diagnosed early and treated adequately.

Chemotherapy and radiotherapy remain a mainstream form of treatment whereas tissue biopsy and scans are general diagnostic tools commonly used in Conventional therapies for cancer. In some cases, a targeted approach is lacking and patients can be vulnerable to certain types of drugs. Recently, new treatments have been emerging to improve the traditional options in cancer treatment with poor prognosis. Areas like nanomedicine and extracellular vesicles along with advances in immunotherapy and nanotechnology are becoming a norm for the next generation of cancer diagnosis and treatments.

Liquid Biopsy

Molecular targeting of specific oncogenic mutations in human cancer is now key for anti-cancer drug therapy as mutations lead to drug resistance. Therefore, the ability to detect and continuously monitor oncogenic mutations is important as it guides the use of targeted molecular therapies to improve long-term clinical outcomes in patients. Apart from direct sampling of cancer tissue by biopsy, oncogenic mutations are also detectable in circulating bodily fluids of patients which is a less invasive method.

Cancer biomarker discovery using DNA aptamersBiomarkers are molecules able to indicate specific physiological states of cells. Identifying reliable biomarkers is essential for early diagnosis and adaptive treatment strategies. According to pub.vsc.org, aptamers are single-stranded oligonucleotides generated by an in vitro screening method called Systematic Evolution of Ligands by Exponential Enrichment (SELEX). They can recognise their cognate targets with selectivity and affinity comparable to protein antibodies in cancer patients.

Nanomedicine

Treating cancer with nanotechnology has become one of the emerging trends. Studies reveal that treating cancer by nanoparticle enhances the efficiency of the treatment and also minimises adverse effects. The property of nanoparticles in treating cancer is target specific. Nanoparticles also target uncontrolled cell proliferation.

Extracellular vesicles (EVs) are released by all cells within the tumour microenvironment, such as endothelial cells, tumour-associated fibroblasts, pericytes, and immune system cells. The EVs carry the load of parental cells formed of proteins and nucleic acids, that convey cell-to-cell communication and also suppress tumour progression. Due to longevity of vesicles within the circulation and their ability to cross bloodbrain barriers, modification of these unique organelles offers the potential to create new biological-tools for cancer therapy.

These treatments help ones immune system to find and attack cancer cells the same way it attacks bacteria and viruses. It uses substances made by the body or in a laboratory to improve or restore immune system function. Immunotherapy may work by maximising the immune system to prevent or slow down the growth of cancer and reduce the probability of spreading. Some examples of immunotherapy, include, NK Cell therapy, Cancer vaccines (prophylactic or therapeutic) and T-cell therapy.

Commonly use in Integrative medicine and in conjunction with radiation, hyperthermia is a non-invasive method of increasing tumour temperature to stimulate blood flow and improve oxygenation. This makes cancer cells more sensitive during radiation therapy. Hyperthermia helps address the limitations of radiation for many patients by effectively increasing the radiation dose without increasing in unwanted side effects. There are significant results which show the effect of hyperthermia approach in treating cancer.

Longdom.org states that this treatment uses a drug called photosensitizer or photosensitizing agents. Agents and particular type of light are exposed at a specific wavelength. The specificity of wavelength depends on the production of oxygen. Oxygen destroys nearby Cancer cells. The wave length determines the distance travelled by the light into the body. The photosensitizer present in a tumour absorbs the light and produces oxygen which destroys surrounding cancer cells.

This treatment uses light amplification by the stimulated emission of radiation. Laser therapy for treating cancer includes special light beams instead of instruments. Laser therapy is normally given through an endoscopic tube. There are different types of laser therapies used for treatment of cancer. The Endoscope is inserted in the body to treat cancer or precancerous growth. Lasers can also be used to shrink or destroy tumours or precancerous growth.

The initial stage, which is most important, is the detection of cancer. Early detection could increase the possibility of cure and increases survival rates. However, poor prognosis due to lack of proper diagnosing methods and ineffective chemotherapeutic treatment is a common hurdle. As synthetic drugs cause many side effects, and cancer cells become resistant, more innovative treatment methods must be considered to give new hope for existing sufferers.

Author: Ezree Ebrahim, Business Development Consultant (Healthcare), Akesis Life by Absolute Health. For Further information, please contact: ezree.ebrahim@akesisoncology.com

Series Editor: Christopher F. Bruton, Executive Director, Dataconsult Ltd, chris@dataconsult.co.th. Dataconsults Thailand Regional Forum provides seminars and extensive documentation to update business on future trends in Thailand and in the Mekong Region.

More here:
Cancer in the workplace: Innovative diagnostic devices and treatments - Bangkok Post

MagForce AG: ‘NanoTherm School’ successfully enters its second round with Module B – PharmiWeb.com

DGAP-Media / 11.12.2019 / 09:30

MagForce AG: 'NanoTherm School' successfully enters its second round with Module B

Berlin, Germany and Nevada, USA, December 11, 2019 - With "Module B - Advanced Course 1: - stereotactic Instillation" MagForce AG (Frankfurt, Scale, Xetra: MF6, ISIN: DE000A0HGQF5), a leading medical device company in the field of nanomedicine focused on oncology, conducted the second round of its 'NanoTherm School' in November. The application training series was launched in January 2019 to provide the highest quality of treatment through ongoing support for physicians and certify surgeons in the use of the innovative NanoTherm technology. Same as the first session, "Module A - The Basics", which took place at the end of January 2019, Module B, focusing on advanced techniques, was met with great excitement from participants.

The NanoTherm School is part of MagForce's roll-out strategy focusing on a broad geographic coverage to provide greater availability while also constantly working on further optimizing its therapy system and educating medical professionals in its use to provide brain tumor patients with the best care possible. The training concept of NanoTherm School was developed in close collaboration with Prof. Dr. Walter Stummer, PD Dr. Dr. Oliver Grauer, and Dr. Michael Schwake, University Hospital Mnster, and PD Dr. Johannes Wlfer, Hufeland Klinikum GmbH Mhlhausen, drawing on their long-standing experience in the treatment of brain tumor patients with the NanoTherm therapy system.

Participants again included the team of Prof. Dr. med. habil. Jan-Peter Warnke, Senior Consultant in the Neurosurgical Clinic at the Paracelsus Clinic in Zwickau, with whom MagForce entered into a cooperation agreement in June 2019. Installation of the mobile treatment center was completed in summer. The NanoActivator is now ready for use at the clinic after receipt of final approval and and is now available for the treatment of patients with brain tumors.

Prof. Dr. med. habil. Jan-Peter Warnke, Senior Consultant in the Neurosurgical Clinic at the Paracelsus Clinic in Zwickau, added "Innovation is extremely important in medicine and has served our patients well. Obtaining the appropriate training in new technologies and techniques is a vital part of adopting these advances into our standard treatment regimens. Practical trainings such as MagForce's NanoTherm School are therefore very welcomed as they allow neurosurgeons to ease into the method while developing the necessary skills. Thanks to the excellent preparation and support of the MagForce team, as well as the opportunity to practice NanoTherm therapy in the most practical and extremely well-structured way, we are well prepared for the use of the therapy system at our clinic starting immediately. The use of new teaching methods for advanced technologies helps us to bring outstanding inventions to patients."

About NanoTherm SchoolTargeted towards medical professionals working in the fields of neuro-surgery and neuro-oncology, the NanoTherm Therapy School series aims at introducing participants to the theoretical knowledge and practical techniques required to successfully apply MagForce's NanoTherm technology for the treatment of brain tumors. In practicing their skills with human specimens, participants are able to familiarize themselves with the procedures and device usages in a stress-free environment under largely real operating conditions.

The NanoTherm School is designed in three consecutive modules allowing participants to gain knowledge and understanding of MagForce's NanoTherm technology starting from basic application techniques (nanopasting) and building to advanced techniques and new surgical application forms in the final module (Module C). The practical section of the course is complemented by lectures on directly relevant aspects of NanoTherm therapy, as well as sample preparation and surgical videos. The equipment and facilities used during the course meet the requirements of today's state-of-the-art surgical equipment.

For more information about NanoTherm School, please contact:Dipl.-Ing. Tobias Hanitsch (thanitsch@magforce.com)Marcel Pilz (mpilz@magforce.com)

About MagForce AG and MagForce USA, Inc.MagForce AG, listed in the Scale segment of the Frankfurt Stock Exchange (MF6, ISIN: DE000A0HGQF5), together with its subsidiary MagForce USA, Inc. is a leading medical device company in the field of nanomedicine focused on oncology. The Group's proprietary NanoTherm therapy system enables the targeted treatment of solid tumors through the intratumoral generation of heat via activation of superparamagnetic nanoparticles.

NanoTherm(R), NanoPlan(R), and NanoActivator(R) are components of the therapy and have received EU-wide regulatory approval as medical devices for the treatment of brain tumors. MagForce, NanoTherm, NanoPlan, and NanoActivator are trademarks of MagForce AG in selected countries.

For more information, please visit: http://www.magforce.com.Get to know our Technology: video (You Tube)Stay informed and subscribe to our mailing list

Disclaimer This release may contain forward-looking statements and information which may be identified by formulations using terms such as "expects", "aims", "anticipates", "intends", "plans", "believes", "seeks", "estimates" or "will". Such forward-looking statements are based on our current expectations and certain assumptions, which may be subject to a variety of risks and uncertainties. The results actually achieved by MagForce AG may substantially differ from these forward-looking statements. MagForce AG assumes no obligation to update these forward-looking statements or to correct them in case of developments, which differ from those, anticipated.

End of Media Release

11.12.2019 Dissemination of a Press Release, transmitted by DGAP - a service of EQS Group AG.The issuer is solely responsible for the content of this announcement.

The DGAP Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases. Archive at http://www.dgap.de

Visit link:
MagForce AG: 'NanoTherm School' successfully enters its second round with Module B - PharmiWeb.com

Exploring the Diversity of Parkinson’s Proteins – Technology Networks

Parkinsons and multisystem atrophy (MSA) both of them neurodegenerative diseases are associated with the accumulation of alpha-synuclein proteins in the brain. Researchers at the German Center for Neurodegenerative Diseases (DZNE) and the Max Planck Institute for Biophysical Chemistry (MPI-BPC) have investigated the molecular makeup of these protein deposits finding structural diversity. Experts from South Korea, Australia, and Argentina were also involved in the study. The results suggest that Parkinsons might be related to diverse types of protein aggregates.

Alpha-synuclein is a protein that occurs naturally in the body. It is assumed to be involved in signal transmission between neurons. The protein appears both at the cell membrane and solved floating, so to speak - in the cells interior. In addition to these normal variants, there are others that manifest in brain diseases. This applies e. g. to Parkinsons disease and MSA. Both can be associated with various neurological impairments, including movement disorders. In Parkinsons and MSA alpha-synuclein molecules stick together. As a result, elongated aggregates arise that are deposited inside neurons and other brain cells. These deposits successively appear in various areas of the brain. They are a disease hallmark, explains Prof. Markus Zweckstetter, who heads a research group at the DZNE and the MPI-BPC. There is evidence that these aggregates are harmful to neurons and promote disease progression.

A matter of folding

These deposits represent a potential starting point for medicines. The idea is that drugs might prevent alpha-synuclein molecules from sticking together or dissolve existing aggregates. To identify potential docking sites for agents, data on the aggregates fine structure is required. Thus, the question is: What kind of shape (also known as folding) do the molecules adopt within the aggregates? So far, information on this topic had been limited to data from laboratory experiments. Previous studies investigated the molecular structure of aggregates that were synthesized in a test tube. We asked ourselves how well such artificially produced specimens reflect the patients situation. That is why we studied aggregates generated from tissue samples from patients, said Zweckstetter. We collaborated closely with international partners on this project. In fact, the tissue samples originated in Australia and the aggregates were synthesized in South Korea. We then did the structural studies in Gttingen.

Aggregates from brain samples taken from five deceased Parkinsons patients and five deceased MSA patients were examined. For comparison, the researchers artificially produced different variants of alpha-synuclein aggregates. For this, they used standard procedures. To compare the structure of the different aggregates, they applied nuclear magnetic resonance spectroscopy and other methods.

Structural differences

We found that aggregated proteins that came from the lab were structurally different to all aggregates generated from patient material, Dr. Timo Strohker, first author of the study, commented on the findings. In addition, proteins of MSA patients differed from those of Parkinsons patients. If one looks at the data more closely, you notice that the proteins of the MSA patients all had a largely similar shape. The proteins of the patients with Parkinsons were more heterogeneous. When comparing the proteins of individual Parkinsons patients, there is a certain structural diversity.

The alpha-synuclein proteins of all aggregates contain beta sheets, which is in line with previous investigations. Accordingly, the molecular backbone is twisted in a way that the proteins are largely two-dimensional. Within the aggregates, the proteins stick together in layers. However, folding does not encompass the whole protein. Each protein also contains areas that are unstructured. Besides, orientation of the beta sheets bears significance. It is a question of how much of a protein is folded and also how it is folded, Zweckstetter stated.

Various types of aggregates in Parkinsons

In the structure of the alpha-synuclein associated with Parkinsons, there were some significant differences between patients. This might be due to the fact that the course of Parkinsons can vary quite considerably between individuals. The variability of Parkinsons disease could be related to differences in the folding of aggregated alpha-synuclein. This would be in contrast to the one disease-one strain hypothesis, that is to say that Parkinsons disease is associated with one, clearly defined aggregate form. However, in view of our relatively small sample of five patients, this is just a guess, said Zweckstetter. Yet, our results certainly prove that studies with tissue samples from patients are necessary to complement lab experiments in a sensible way.

Reference

Strohker et al. (2019) Structural heterogeneity of -synuclein fibrils amplified from patient brain extracts. Nature Communications. DOI: https://doi.org/10.1038/s41467-019-13564-w

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

See the original post:

Exploring the Diversity of Parkinson's Proteins - Technology Networks

Biologics Market Size Expand at a CAGR of 3.9 With $399.5 Billion By 2025 – MENAFN.COM

(MENAFN - Grand View Research)

Latest Study by Grand View Research, Inc. titled Biologics Market Analysis By Source (Microbial, Mammalian), By Products (Monoclonal Antibodies, Vaccines, Recombinant Proteins, Antisense, RNAi), By Disease Category, By Manufacturing, & Segment Forecasts, 2018 - 2025 announce that the global biologics market is anticipated to reach USD 399.5 billion by 2025, according to a new report by Grand View Research, Inc. Introduction of targeted therapies coupled with rising adoption of patient centric personalized medicine anticipated to fuel demand. Ever-increasing understanding of the cell physiology and stress, as well as the factors involved in protein production and heterologous gene expression have empowered the use of different living factories.

Some key findings from the report:

These living factories are the prokaryotic and eukaryotic cells. Enhancement of drug functionality through achieving successful protein folding and post-translational modifications is supportive for projected progress rate.

Moreover, rising adoption of biopharmaceuticals over chemically synthesized molecules is expected to propel revenue generation significantly. In addition to this, presence of several metabolic disorders that can be treated through the use of biologics is attributive to influence demand.

Combination of advanced bioengineering technologies for biopharmaceutical production is expected to boost progress in pharmaceutical industry. With recent advances in automation, the selection process can be done through high throughput screening (HTS) system for selection of viable clones.

Aforementioned method enables robust production of biopharmaceutical products by obtaining high-producing cell line. Advances with respect to upstream and downstream processing would directly translate into the growth in revenue for this market at a larger level.

However, development of biosimilars is expected to restrain the biologics year on year growth to certain extent. Although, the regulatory approval pathway for these products is not framed yet some drug manufacturers are opting to invest in the development of biobetters.

For More Details Please Visit To This Link: https://www.grandviewresearch.com/industry-analysis/biologics-market/

The final report on global biologics market has been segmented on the basis of application and region:

Biologics Source Outlook (Revenue, USD Billion, 2014 - 2025)

Biologics Product Outlook (Revenue, USD Billion, 2014 - 2025)

Biologics Manufacturing Outlook (Revenue, USD Billion, 2014 - 2025)

Biologics Disease Category Outlook (Revenue, USD Billion, 2014 - 2025)

Biologics Regional Outlook (Revenue, USD Billion, 2014 - 2025)

Get Sample of biologics market @ https://www.grandviewresearch.com/industry-analysis/biologics-market/request/rs1/

Media Contact

Sherry James

Corporate Sales Specialist, USA

Grand View Research, Inc.

Phone: 1-415-349-0058

Toll Free: 1-888-202-9519

Email: sales@grandviewresearch.com

Web: https://www.grandviewresearch.com

MENAFN1012201900702939ID1099403669

Read the rest here:

Biologics Market Size Expand at a CAGR of 3.9 With $399.5 Billion By 2025 - MENAFN.COM

Ancient Worm Reveals Way to Destroy Toxic Cells Potential New Therapy for Huntingtons and Parkinsons – SciTechDaily

Associate Professor Roger Pocock, from the Monash Biomedicine Discovery Institute (BDI), and colleagues from the University of Cambridge led by Professor David Rubinsztein, found that microRNAs are important in controlling protein aggregates, proteins that have amassed due to a malfunction in the process of folding that determines their shape.

Their findings were published in eLife on December 4, 2019.

MicroRNAs, short strands of genetic material, are tiny but powerful molecules that regulate many different genes simultaneously. The scientists sought to identify particular microRNAs that are important for regulating protein aggregates and homed in on miR-1, which is found in low levels in patients with neurodegenerative diseases such as Parkinsons disease.

The sequence of miR-1 is 100 percent conserved; its the same sequence in the Caenorhabditis elegans worm as in humans even though they are separated by 600 million years of evolution, Associate Professor Pocock said.

We deleted miR-1 in the worm and looked at the effect in a preclinical model of Huntingtons and found that when you dont have this microRNA theres more aggregation, he said. This suggested miR-1 was important to remove Huntingtons aggregates.

The researchers then showed that miR-1 helped protect against toxic protein aggregates by controlling the expression of the TBC-7 protein in worms. This protein regulates the process of autophagy, the bodys way of removing and recycling damaged cells and is crucial for clearing toxic proteins from cells.

When you dont have miR-1, autophagy doesnt work correctly and you have aggregation of these Huntingtons proteins in worms, Associate Professor Pocock said.

Professor Rubinsztein then conducted research which showed that the same microRNA regulates a related pathway to control autophagy in human cells.

Expressing more miR-1 removes Huntingtons aggregates in human cells, Associate Professor Pocock said.

Its a novel pathway that can control these aggregation-prone proteins. As a potential means of alleviating neurodegenerative disease, its up there, he said.

Additional work by Associate Professor Pococks colleagues showed that when human cells are supplied with a molecule called interferon-b the miR-1 pathway is upregulated, revealing a way of manipulating it.

He said the studies demonstrated the fundamental importance of discovery research. We asked a fundamental biological question to dissect a molecular mechanism that now is shown to be really important for potential therapies.

The researchers have provisionally patented their findings and are in discussions with pharmaceutical companies about translating the research. They will further test it in preclinical models for Huntingtons and Parkinsons disease.

Reference: Interferon--induced miR-1 alleviates toxic protein accumulation by controlling autophagy by Camilla Nehammer, Patrick Ejlerskov, Sandeep Gopal, Ava Handley, Leelee Ng, Pedro Moreira, Huikyong Lee, Shohreh Issazadeh-Navikas, David C Rubinsztein and Roger Pocock, 4 Dcember 2019, eLife.DOI: 10.7554/eLife.49930

This research was supported by the Australian NHMRC.

See original here:

Ancient Worm Reveals Way to Destroy Toxic Cells Potential New Therapy for Huntingtons and Parkinsons - SciTechDaily

Its Time to End the Vegan Tax – LIVEKINDLY

Its been 15 years since Starbucks started carrying soy milk in its stores in 2004. Since then, weve had two new presidents, we found out Pluto wasnt a planet, and weed became legal in 10 states. So much has happened. But for some reason, were still being charged extra for soy.

In 2004, the world was much different for vegans. Often, the only plant milks you could find on grocery shelves were in non-refrigerated tetra packs: likely rice and soy milks found in the baking aisle. Vegan cheeses were pretty much nonexistent unless you lived in a larger city with boutique nutrition-focused stores or were willing to pay a lot in shipping. And when they arrived, you realized they didnt really resemble cheese at all.

Though the products available that year didnt hold a candle to the Miyokos of today, I was just as excited to try the brand-new options then as I am now. Giving up dairy meant significantly reducing my carbon footprint, lowering my risk of breast cancer and saving thousands of gallons of water per year. When anyone gives up dairy, vegan or not, theyre doing a favor to their health, society and the planet. Despite having lackluster options, the mere fact that they existed was cause enough to celebrate.

When Starbucks started carrying soy milk as an option, a whole new world opened for non-dairy folks like myself. They charged an extra $0.80 to switch out dairy for soy milk and I happily bought expensive coffee drinks without thinking twice about the extra charge. Soy milk is more expensive, so Ill pay extra, seemed to make sense. Thankful for being noticed, vegans and lactose-free customers feltincludedby the corporate coffee giant, not taken advantage of. We knew that this was likely seen as a trend and were happy big companies were jumping in with us.

Now, a decade and a half later, pretty much every coffee shop carries soy milk, many offering almond, coconut, oat and other alternatives as well. Were in a whole new era, where veganism is not only represented on menus, but were specifically sought after as customers. This isnt an accident. Veganism is growing at a quick rate: The number of U.S. consumers who identify as being vegan increased about 600% between 2014 and 2017, and a much larger percent of Americans are sometimes choosing plant-based alternatives despite not claiming the lifestyle. Corporate giants like Tyson and Hormel are investing in and releasing their own plant-based meat alternatives and now, plant milks are snatching up about 15% of overall dairy sales.

Despite these immense changes, though, vegans are still being individually charged for replacing dairy with plant alternatives. In fact, were being chargeda lot.On average, you can expect to spend somewhere between $0.50 and $1.00 extra for every latte and up to $5.00 for every pizza you veganize. It may not seem like much, but for many people, that cost can add up to hundreds of dollars per year.

Coffee beans themselves are sold at different rates, depending on their origin, current market value, and type. However, youd be hard-pressed to find a coffee shop that charges a different price for each type of brewed black coffee.

Im not asking to be charged less than what my meals or drinksactuallycost. Im asking for the costs to be rolled into one, like they do for coffees and other food groups, instead of being charged an extra fee on top of what is a fixed cost for everyone else. Coffee beans themselves are sold at different rates, depending on their origin, current market value, and type. However, youd be hard-pressed to find a coffee shop that charges a different price for each type of brewed black coffee. When building their menus and deciding on pricing structures, restaurants and shops add up all the ingredients and average out their operating costs across the general menu set. They do this in order to make the most amount of profit and to avoid charging $20 for some meals and $5 for others: many of us would be surprised to see what the actual costs were at most restaurants for similarly priced meals.

Pizza is a great example as well. Bell peppers cost more than twice as much as onions but are always included together as one fixed price on pizza menus, each costing around $0.50 to $1.00 to add to a pizza, with no differentiation in price despite costing different amounts for the restaurant. I doubt that many people have ever questioned this discrepancy.

So what if we did the same with plant milk?

The monetary cost isnt all Im worried about. Seeing your food as something abnormal really takes a toll on customers vegans, those with gluten intolerance, and people with allergies often feel like unappreciated outsiders and that our patronage is inconvenient or hurts the company were supporting, rather than helps. To a cynic like myself, it often feels like Im not just being charged because my food costs more, but because they rely on that extra charge to increase profits.

The discrepancy between what some shops charge and what others do is enormous, and illuminates how the upcharge is disconnected from economic realities. Customers are charged anywhere from $0.25 to $1.25 to sub in a vegan dairy alternative. This doesnt even correlate to the actual price difference between the two, which is generally around five cents per 12 ounce latte (based on quick research of national averages of costs of dairy and soy milk). And vegan coffee shops, where they sell nothingbutplant-milks, seem to be doing just fine: Chris Rios, who owns East Austin Coffee, a 100% vegan shop, says I feel that our costs are about the same. Even though we dont charge extra for plant-based milk, we are competitively priced versus other premium local coffee shops.

Extra charges have a place: when youre purchasing more. An additional cost for ordering avocado on your burger, cheese on your fries, or a pump of vanilla syrup in your latte makes sense. But when we order a latte with plant-milk, were switching out an ingredient, not doubling up the size of our drink.

Perhaps if plant milks werent an extra charge, more customers would try them. When companies charge an extra fee to individual customers, theyre alienating vegans and making a plant-based choice less desirable for non-vegans. Nolan Green, the owner of Machine Head Coffee in Austin, TX sees a third of his customers ordering drinks without dairy, and he recently ditched the extra charge for plant milk after seeing a popular post on Instagram that called the extra charge into question. He says even though most of his customers arent vegan, he views it as an opportunity to reach someone who is reluctant to try a plant-based product.

When we see restaurants willingly changing their menus to accommodate some causes, but not vegan ones, its easy to think they simply dont care about the harm dairy does to human bodies, animals welfare, and the environment. But its more likely that they simply dont see a reason to stop charging extra since no one is really complaining about it.

Compelling restaurants to absorb costs for more ethical options isnt unprecedented. In fact, its something some activists have accomplished. Working with local governments and inspiring small feats of change at the societal level, environmentalists have made it pretty much an abomination to serve food and drinks in Styrofoam containers, which take 500 or more years to decompose. At many restaurants in larger cities, customers expect their takeout containers to be made from compostable or recyclable materials. In some cities, like Seattle, its the law. And the cost of switching to compostable materials is heavy: over twice the cost of less environmentally-friendly products. Restaurants arent switching to earth-friendly material at their own loss, either: theyre passing on the cost to customers within their menu set, and not externally, which is exactly what they should be doing with vegan alternatives. Perhaps environmentalists have achieved something vegans havent quite mastered: the art of making these issues everyones business.

Is it so easy, though? When we see restaurants willingly changing their menus to accommodate some causes, but not vegan ones, its easy to think they simply dont care about the harm dairy does to human bodies, animals welfare, and the environment. But its more likely that they simply dont see a reason to stop charging extra since no one is really complaining about it. If it doesnt seem to be broken, why fix it?

Thats when I really feel like its a vegan tax. A lot of places seem to go very light on the vegan cheese, but not so light on the up-charge for it.

So, should we be thankful that businesses offer non-dairy alternatives at all? Yes, absolutely. We should celebrate companies who recognize the market for more ethical ingredients. But when we forget that businesses exist to serve the needs of their consumers, we sell our buying power short. Robbie Lordi owns Lil Nonnas Pizza in Austin, TX, which switched to an all-vegan menu about a year ago in 2018. His advice to other restaurants? If you are trying to bring vegans to your restaurant, I highly suggest not up-charging non-dairy options. You are actively including a whole new customer base that may not have had another reason to patronize your business. I get not needing to attract vegan customers, but what I find most objectionable is when the up-charge is disproportionate to the cost. Thats when I really feel like its a vegan tax. A lot of places seem to go very light on the vegan cheese, but not so light on the up-charge for it.

Starbucks didnt start offering soy milk to its customers as charity. They were meeting the ever-increasing demand for plant milks; a demand that has only intensified as time has gone on. In a recent poll by Ipsos-mori, over 50% of American consumers stated they purchased plant-based milk alternatives. Instead of simply being appreciative of corporations who offer these alternatives at an upcharge, we should be alarmed that theyre not absorbing the costs into their menu sets after years of data has proven that plant milks are thefuture, and not simply a trend. 15 years is too long. Vegans and our plant-based alternatives are not going away, but the vegan tax should.

*Reprinted with permission from Tenderly.

Summary

Article Name

It's Time to End the Vegan Tax

Description

Should you have to pay a surcharge for vegan food and drinks? It's 2019 and time to end the upcharge tax once and for all.

Author

Britty Hamby

Publisher Name

LIVEKINDLY

Publisher Logo

Go here to see the original:

Its Time to End the Vegan Tax - LIVEKINDLY

3 Habits for a Healthier Lifestyle – The UCSD Guardian Online

Between school, work, and student organizations, life as a college student can be a bit overwhelming. It may seem like you cant get a grip on your life and are barely afloat, but I have some news for you. You can take hold of your life and change those negative patterns and mindsets to one that prioritizes yourself. When you prioritize yourself, everything else falls together. These habits may seem obvious and you may already be practicing them but maybe not so efficiently. Incorporating these habits into your lifestyle and making them a part of your daily routine will create a reduction in your stress levels and a change in your mental and physical states. You should first get the basics down and then progress, because there is no quick fix to health and fitness. Taking care of your mental state will make it easier to maintain a healthy lifestyle.

Habit One: Write Out Your Schedule

The first one seems obvious but isnt often executed properly for individuals, leading to an increase of stress, lack of sleep, or mood swings. So, create a schedule. Get a planner and write each day out. You may even need to do this by the hour depending on how busy your schedule is. Next, copy what you have written down into your notes and reminders on your phone so your schedule is always accessible and you have reminders to keep you on track. Although this seems like it will not give you as much free time as you want, in the grand scheme of things, it will save you from stress and mental breakdowns. Creating a routine helps you prioritize what is truly important and aligns your mindset to your goals.

Habit Two: Create a Sleep Schedule

The second is creating a sleep schedule. I know this may be hard because each day changes, but it could aligns with your scheduled out days/routine. Compared to your current sleep schedule, if you went to bed one hour earlier and woke up one hour earlier, it would give you that extra hour you wished you had. Waking up early reduces stress levels, helps with success, and stabilizes your emotions and mindset. In the article The Scientific Argument for Waking Up Early, Stanford Psychologist BJ Fogg states that willpower is not how you build good habits. Instead, you need to design your environment and life for them. You need to get small wins every single day, which stack on top of each other. Alter your no time mindset to a prioritized mindset.

Habit Three: Alter Your Mindset

The last habit, altering your mindset, is what stabilizes the change to a healthier lifestyle. This is the overall habit that will truly make any other habit stick. Essentially, if you get out of that negative mindset to a focused mindset, you will realize how much time you waste on unnecessary things. Reset, readjust, restart, refocus as many times as you need to is one of my favorite quotes because there is no pressure on getting it right the first time. Changing your lifestyle is hard and you might fail, but as long as you keep resetting , you will get a hold of it. By readjusting your mindset, it will essentially give you more free time to study, do homework, workout, nap, and then relax and watch TV. I personally schedule out my whole day by the hour and designate timeframes for naps, workouts, and leisure time. Whenever I stray away from the schedule, I fall into this pit of doing nothing and it induces my stress, making me either lose sleep or put me behind. That is why it is important to have this altered mindset stick.

This all leads to the underlying theme: time management. Time management is so important because it will create schedules that will have extra time that you didnt realize exists. Create the life you want. Take life by the horns and control it. Save yourself from the mental breakdowns, anxiety attacks, spent money, and wasted time and have that healthier lifestyle mentally and physically. Your mental health should be the main priority, so do yourself a favor and do anything that can benefit it. You only have one body, so treat it kindly.

See original here:
3 Habits for a Healthier Lifestyle - The UCSD Guardian Online

How can the health-care system reward healthy behavior? – The Grand Junction Daily Sentinel

Sadly, despite the highest per-capita health care spending in the world, our statistical life expectancy in the U.S. is declining for three years running. It's past time to address the issues of chronic disease at the root of this trend. But to do so, health insurance needs to take a few lessons from auto insurance.

Auto insurance companies regularly offer discounts for safe driving. Conversely, traffic accidents and speeding lead to rate increases. In addition, Car Insurance.com reports that a DUI can increase an individual's auto insurance rates anywhere from 80% to 371%.

Without these potential auto insurance policy rate increases, our roads would be less safe while being more expensive for the habitual safe and responsible drivers. Interestingly, nobody ever decries these traffic law and auto insurance policies as "nanny state" techniques.

Auto insurance rewards healthy driving while penalizing poor driving.

On the other hand, health insurance fails this sustainability test.

Via commercial insurance, Medicaid, and Medicare rates and taxes rise for everyone because of the unhealthy behavior of some while offering insignificant rewards for healthy behavior. This is a perfect recipe for financial unsustainability in any health-care system, let alone within the most expensive one on the planet.

So what is the health insurance equivalent of speeding or driving under the influence of drugs or alcohol? More importantly, what happens to an individual's health insurance premium for avoidable and well established behaviorally related health problems? Other than some rate adjustments for smoking nothing happens. Worse yet, as the total cost of care for a population increases from avoidable chronic disease states, health insurance rates for everyone increase. Plus, we pay more in taxes to fund Medicaid and Medicare.

The challenge in health insurance is to find a method to reward healthy behavior without driving up health insurance premiums for the chronically ill and those with unfortunate health-related events of no fault of their own.

We could offer relatively inexpensive health insurance to a healthy cohort of patients. Unfortunately, this policy would drastically increase health insurance rates for the sick and chronically ill. Given the extraordinary cost of health care in the United States, it is necessary to spread the cost of care over the majority of the population.

So how does a community, state, or nation rise to the challenge and find a mechanism to reward healthy behavior while disincentivizing unhealthy behavior? An advanced society with affordable health insurance will boldly address this challenge.

The answer lies in the ability to utilize the health insurance equivalents of speeding or reckless driving. Fortunately for us, the Centers for Disease Control or CDC has already accumulated the necessary data. The CDC has identified the most costly behaviors relevant to health insurance: the use of tobacco, alcohol, and sugar-based beverages. As per the CDC, the United States' health care system spends over $700 billion per year treating acute and chronic disease related to the use of these products.

In effect, the "safe drivers" among us are paying this annual $700 billion tab. It's time for a refund. We must begin rewarding healthy behavior in health insurance. Currently, the cost of public and private health insurance includes the cost of caring for many chronic diseases caused by human behavior. The public can smoke, vape, drink, chew, eat and ingest a well-documented variation of unhealthy products. Correspondingly, the price of health insurance increases for everyone.

This is why the largest physician organization in the state of Colorado has enacted policy that could help Colorado lead the nation in addressing the chronic disease epidemic. In November, the Colorado Medical Society voted to support increased taxes on alcohol, tobacco, and sugar-based beverages as long as those taxes be used to address the high cost of health care by addressing chronic disease where it starts and by rewarding those who choose a healthy lifestyle. The Mesa County Medical Society led the charge.

The policy does not support taxes on these products if the revenue is allowed to go to the general fund. If revenue is used for prevention and reducing premiums, there is a healthy return on investment for a Colorado consumer who chooses a healthy lifestyle. It is a tax that is then returned to the well- deserved healthy consumer of health insurance.

This tax policy works like our traffic laws. Healthy living is rewarded while we simultaneously work to reduce the rate and ill effects of unhealthy behavior. And, at the same time, we preserve the insurance pools such that health insurance rates don't go up for the chronically ill with "no-fault" health problems.

With enough support, Colorado could pilot this innovative health policy design for a nation in desperate need of more value per health care dollar.

To learn more, view Dr. Pramenko's TED Talk: "Marketing Healthy Behavior."

Michael J. Pramenko M.D. is the executive director of Primary Care Partners. He is chairman of the Board of Monument Health and is a past president of the Colorado Medical Society.

Visit link:
How can the health-care system reward healthy behavior? - The Grand Junction Daily Sentinel

Medications as effective as stents for most with coronary artery disease – Harvard Health Blog – Harvard Health

How best to treat a patient with stable coronary artery disease (CAD)? The cardiology community has debated this question for decades, arguing whether its best to take a conservative or invasive approach.

The ISCHEMIA trial (ischemia means not enough oxygen is getting to the heart muscle), a new study reported at Novembers American Heart Association meeting, provides some answers. This study suggests that for most, managing CAD with medications alone (the conservative approach) is as safe and effective as the more invasive strategy of cardiac catheterization and opening of the blocked artery.

ISCHEMIA followed over 5,000 patients with significant narrowing in one or more coronary arteries. Half of the patients were randomly selected to receive conservative treatment with optimal medical therapy (OMT) and lifestyle changes to treat risk factors such as high blood pressure and high cholesterol. The other half were given OMT and also sent for cardiac catheterization (threading of a flexible catheter into the heart arteries to look for narrowed or blocked coronary blood vessels). When blockages were found, these patients underwent placement of a small mesh tube, called a stent, to prop open the affected area. When blockages were too complex for stent placement, open-heart surgery was performed.

The findings were surprising. Many cardiologists would have predicted that the invasive strategy would be superior to the conservative strategy. The group that received stents did report greater relief of angina, or chest pain. But there was no significant difference between the two groups in terms of rates of heart attack, death, or hospitalization for worsening heart pain.

Proponents of the conservative approach argue that OMT makes more sense than stenting because it addresses all the arteries in the heart, not just the small section of narrowing addressed by a stent that may be causing angina but may not represent a risk to health.

Since their introduction in the 1980s, stents have been widely used in the treatment of CAD. Stents are effective at relieving angina in patients who continue to experience symptoms despite being on appropriate medicines. Angina refers to the symptoms typically pressure or tightness across the chest that occur when the heart muscle does not get enough oxygen-rich blood.

Angina is a symptom of advanced atherosclerosis, a process of inflammation and plaque formation that leads to blood vessel narrowing. If an atherosclerotic plaque ruptures, this can trigger the formation of a blood clot, severely and suddenly obstructing blood flow. Depending on the degree of obstruction and which artery is involved, this may cause abrupt worsening of angina, called unstable angina, or death of the heart muscle, called a heart attack. Unstable angina occurs at rest, or with increasingly little exertion.

Patients experiencing unstable angina or heart attack almost always require urgent cardiac catheterization, and often stent placement.

Unlike unstable angina, patients with stable angina have more predictable, chronic symptoms that can be managed with medications. Stable angina worsens with exertion or sometimes with emotional stress, and improves with rest. Reduction of stable angina involves improving the mismatch between oxygen supply and demand. This can be accomplished either by lowering demand or improving supply.

Demand can be reduced with OMT, which may include beta blockers, which slow down the heart rate, or nitroglycerin, which decreases the work of the heart by relaxing blood vessels. Statins and aspirin are another important component of OMT, because they help to stem the progression of heart disease, reducing the risk of unstable angina or heart attack. When medication fails, blood supply to the heart muscle can be increased by removing the blockage with a stent or bypassing the blockage with open-heart surgery.

Many cardiologists have assumed that stents are effective, not only at relieving symptoms but also at preventing future heart attacks, leading many to pursue early cardiac catheterizations for their patients with stable angina. However, the ISCHEMIA trial suggests that medications are just as good at preventing heart attacks and death in stable patients.

This is welcome news for patients who previously would have been urged to have a cardiac catheterization and stent placement for stable angina. It now seems clear that these patients can be safely managed with medications alone, avoiding the risk and discomfort of the procedure, not to mention reducing healthcare costs.

ISCHEMIA is not the first study to demonstrate that OMT is a safe and effective alternative to stent placement. But it is the most influential because of its careful design, large number of patients, and comparison of the newest stents and most current medical treatments.

So, how best to manage patients with stable coronary artery disease? A safe and effective long-term strategy for most is to start with medications and healthy lifestyle. For those who continue to be limited by angina, an invasive procedure is appropriate for symptom control. Stents relieve angina, but they do not prevent heart attacks or death.

Read the original:
Medications as effective as stents for most with coronary artery disease - Harvard Health Blog - Harvard Health