Human Longevity Announces the Acquisition of DoctorsForMe – Yahoo Finance

Clients now have access to Massachusetts General Hospital physician network through DoctorsForMe to help treat disease and support long-term health

Human Longevity, Inc., an innovator in providing data-driven health intelligence and precision health to physicians and patients, announced today the acquisition of DoctorsForMe, Inc. The acquisition now allows clients of Human Longevity to access world-class physicians and services of Mass General, well trusted by patients worldwide as one of the best hospitals in the world.

David Karow, MD, PhD, President and Chief Innovation Officer of Human Longevity, commented, "DoctorsForMe uses Big Data and AI technologies to match a patient with a doctor that perfectly matches the patients specific need. The acquisition enables Human Longevity to provide a complete health intelligence solution for our clients from early disease detection to personalized treatment, all with the goal of living a longer, healthier life."

ABOUT HUMAN LONGEVITY

Human Longevity provides unparalleled, precision health analytics to individuals through the Health Nucleus in La Jolla, CA. The Health Nucleus provides an assessment of current and future risk for cardiac, oncologic, metabolic and cognitive diseases and conditions. This is provided via a multi-modal approach, integrating data from an individuals whole genome, brain and body imaging via MRI, cardiac CT calcium scan, metabolic tests and more, using machine learning and artificial intelligence.

View source version on businesswire.com: https://www.businesswire.com/news/home/20200115005207/en/

Contacts

Debbie Feinberg, VP of MarketingHuman Longevity, Inc.858-864-1058dfeinberg@humanlongevity.com

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Human Longevity Announces the Acquisition of DoctorsForMe - Yahoo Finance

Moderna Partners with AWS to Explore the ‘Software of Life’ – BioSpace

The software of life. Thats how Stephane Bancel, the chief executive officer of Moderna, described messenger RNA (mRNA), which is at the core of Modernas drug development process.

Moderna is pioneering mRNA drugs that are believed to be able to direct the body to produce any protein of interest, including antibodies and other proteins that can create therapeutic activity. Bancel said mRNA is an information molecule.

Its like software, he said.

The company, which has secured enormous investments over the past few years, is inching closer to being a commercial company in developing personalized therapies for a wide range of diseases, including cancer. In order to create those personalized medicines, the Cambridge, Mass.-based company relies on gene sequencing and a partnership with one of the worlds largest companies Amazon.

In an interview with CNBCs Jim Cramer during the J.P. Morgan Healthcare Conference this week, Bancel said the company relies on Amazon Web Services to compare every letter of DNA in the sequencing process. Once that is done, the company can deduce what needs to be done to develop personalized medicine, Bancel explained.

Amazon Web Services, the fastest growing division of the company, according to CNBC, provides on-demand cloud computing platforms to companies. Moderna is currently using Amazon Web Services with more than a dozen drug candidates in its pipeline, which means the high-tech platform plays a central role in the companys drug development program. As CNBC explains, the company is using the powerful cloud-based service to speed up the time it takes a drug candidate to move from the preclinical to the clinical phase. In addition to Moderna, Amazon Web Services is being used by several pharmaceutical companies, including San Diego-based Human Longevity Inc., Regeneron Pharmaceuticals and more.

The reliance on the high-speed program could lead to the company finally becoming a commercial entity 10 years after it was launched. Last week, just ahead of JPM, Bancel pointed to one of the companys clinical candidates as a potential blockbuster, an experimental treatment for cytomegalovirus (CMV), the most common infectious cause of birth defects in the United States.

Moderna said the analysis following a Phase I trial, which was taken after the third and final vaccination, shows continued boosting of neutralizing antibody titers in patients. The mRNA-based vaccine, mRNA-1647, is designed to protect against CMV infection. Cytomegalovirus is a common pathogen and is the leading infectious cause of birth defects in the United States with approximately 25,000 newborns in the U.S. infected every year. CMV is passed from the mother to her unborn child. Birth defects occur in about 20% of infected babies. The defects can include neurodevelopmental disabilities such as hearing loss, vision impairment, varying degrees of learning disability and decreased muscle strength and coordination. There is no approved vaccine to prevent CMV infection.

In October, the company received Fast Track Designation from the U.S. Food and Drug Administration for mRNA-3927, its investigational mRNA therapeutic for propionic academia, which is caused by the inability of the body to breakdown certain proteins and fats which leads to the build-up of toxic chemicals. Moderna plans to initiate an open-label, multi-center, dose-escalation Phase I/II study of multiple ascending doses of mRNA-3927 in primarily pediatric patients.

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Moderna Partners with AWS to Explore the 'Software of Life' - BioSpace

Chip Walter is dying for you to read his new book on immortality. Or is he? – NEXTpittsburgh

Is it possible to cure aging?

Chip Walter says yes. The author spent years researching and writing his new book Immortality, Inc.: Renegade Science, Silicon Valley Billions, and the Quest to Live Forever which explores the efforts being taken to cure aging and hence dramatically prolong life.

This is not a work of fiction.

Walter, a science journalist, filmmaker, skeptic and former CNN bureau chief interviewed many authorities, including Craig Venter, the scientist who accelerated the completion of the first human genome and Robert Hariri, one of the worlds leading stem cell experts.

The book, published by National Geographic, is available in bookstores and online. As part of his tour to promote the book, Walter will appear at the Carnegie Library Lecture Hall in Oakland on Thursday, Jan. 16 to discuss the death of growing old. The event, which is part of the Pittsburgh Arts & Lecture Series, is free with registration.

The topic is fascinating with so many implications. NEXTpittsburgh caught up with Walter to ask him some burning questions of our own.

Define immortality. Is it infinite or are we talking hundreds of years?

None of us is going to live forever. Sooner or later well be hit by a bus or lightning, or maybe an angry spouse who just cant stomach celebrating their 400th anniversary! We used the title Immortality, Inc. in the book to differentiate it from simply living a couple of extra years or even a couple of extra decades. So, this book doesnt pretend to have revealed science that will guarantee infinite life, but it does explore scientific advances on the horizon that will very likely diminish and then eliminate aging. And since aging and age-related diseases are the number one reason why we die (one million people a week die of age-related disease), curing aging would radically lengthen healthy life spans into the hundreds of years, crazy as that may sound.

Do we have to cure cancer and conditions like depression first?

The opposite, I think.

If scientists solve aging, then it would also vastly reduce the number of people who die from cancer and many other diseases. The reason most people get cancer is because they are aging. If science can solve the underlying, biological causes of aging, these killer diseases would largely disappear. Well basically grow younger. And, as a rule, most people do not die when they are young unless its from an accident, murder or a severe genetic problem.

So, by curing aging, we will, in one fell swoop, cure much of the cancer, heart disease, Alzheimers and other major diseases. This arguably makes solving aging the best way to eliminate a whole group of diseases, rather than try to track each one down individually like were playing some game of whack-a-mole. In fact, you could argue that these diseases will never be eliminated unless aging is eliminated first. Well just create a series of band-aids, but eventually something will get us.

Issues like depression are more problematic because they are not directly related to aging (though they sometimes can be). But, an additional bonus is that as science attempts to cure aging, we may well develop cures for many diseases that afflict people in their youth genetic diseases, mental and emotional syndromes, viruses, childhood cancer because we will understand the genomics of the human body so much better.

How close are we really to achieving immortality and what will be the first discovery?

I doubt there will be a silver bullet any more than scientists found a silver bullet that would cure cancer when the war against cancer was launched in the 1970s. Its just too complex. But, I do believe that some major advances will be revealed and in use within the next four years. These advances will be incremental, but they will also gather speed. First, I expect to see a far broader use of stem cell technology to repair damaged and diseased bodies from arthritis to kidney disease. A company and scientist I explore in the book (Celularity) is tackling that.

Next, will come major advances as we better understand the human genome. We are gathering more and more information that is enabling us to decode the genome so that we can understand and develop drugs tailored to each individual. But first we have to understand what interactions within our DNA unravel the human body in the first place. ( I explore a company called Human Longevity, founded by genomic pioneer Craig Venter, that is working on that.) Third, based largely on genomics, will come advances that truly unveil why we age at all. Clearly we do. But why? Calico and Apple Chairman Arthur Levinson is working on that.

How will we solve all of these complex problems? Only the development of increasingly robust computing can solve that problem, and that software is advancing at an exponential pace. Ultimately, those machines, working with scientists of many stripes will crack some of these profoundly complex challenges. Generally, I believe those are the four forces that I believe will lead to the end of aging.

Has there been an actual breakthrough and if so, what is it?

There have been breakthroughs, but no cures (because, again, I doubt there will be a silver bullet). But as I reveal in the book, scientists now know, definitively, that genetics is the source behind why we age (or one of the key sources). We also know that certain key genes in other animals (like mice) can be switched, and when they are, the mice live far longer and healthier lives, sometimes more than four times longer. We also know that some mammals simply dont age. They die of other things, but not aging. This was discovered while I was writing the book. Scientists in the book also have discovered what they suspect is the explanation of youth. Why are we born young? How does that happen and then why and how do we age? So, we have already seen significant fundamental advances, and theyll continue to come.

How much of the book is about the personalities and how much is about science?

I did not want to write a book that was just a bland science survey filled with a bunch of facts. Theres a difference between fact and truth. When I first set out to explore and research Immortality, Inc., the main question in my mind was this: are we actually now living in a time when science could solve one of the greatest mysteries the human race has ever faced? And if science can accomplish that, what does it mean? To tell that story I needed to understand the history of the key scientists, and the finances and thinking of those involved. And I needed to gain access to them. It wasnt easy, but eventually I did. Much of what I found is exclusive information. Unknown until now.

In the end I wanted to thread all of those themes together into one larger, compelling story. How did something like this come to be? Who were these scientists? What motivated them? Are they crazy or geniuses? So, I spent a lot of time with all of them and I wrote about who they are and what led them to undertake such a monumental task. Who does that? Once I set the stage for outlining the personalities and the cultural and historical and financial issues, then I dove into the science that these scientists and companies were developing. I think this makes the book a much more compelling human story. At least I hope so.

How would you respond to critics who think the book is more about very wealthy older people in a quest to cheat death?

Well, the simple answer is thats not what the book is about. So folks should read it and theyll see that such an assumption would be off-base. I am sure that there are many well-heeled older people who would like to live longer and healthier lives. And I am sure that there are many not-so-well-heeled people who would as well. That doesnt make them evil. This is only evil if the rich, and only the rich, hold on to technologies that would lead to longer life. That would be wrong. But history shows that as new technologies evolve, costs drop and then they become more ubiquitous. I believe that will happen here. Insurance companies will begin to see that they can save a lot more money by enabling people to remain healthy longer than by paying to have them go into the hospital again and again.

When it comes right down to it, does anyone want to die (unless you are facing horrible physical, emotional or mental pain)? I mean when each of us is facing death, that day, do we really want to blink out? Living is literally wound into our DNA. Every living thing does everything it can to remain alive, until it simply cant anymore. From the beginning of time we have always tried to avoid dying. Thats the origin and purpose of Medicine with a capital M. Now, if we solve that problem and huge numbers of us live exceptionally long, will that create problems? Absolutely. But again, will most people say, Its okay, Ill die so we dont have an over population problem. Lets imagine someone has cancer and science offers a potential solution, do they say, No thanks. Not usually. I suspect the same will be true of drugs and treatments that extend life. A bigger issue in my mind is how, as a society, we are going to deal with a world in which we are living, not decades longer (as we already are), but hundreds of years longer. These advances are going to capsize everything. So I suggest we get a handle on it now.

Did you discuss immortality with any religious leaders or people in the death care industry? What were their thoughts?

I did speak to those people, but I didnt get deeply into it in the book or it would have been 600 pages long. Peoples feelings about this are all over the map, pro and con. There is, however, no religion that fundamentally holds that we must die. Some people, however, do feel its wrong to want to cheat death. That somehow its unnatural or that God wants us to die. But if this were universally true, then why take antibiotics? Why try to save people from automobile accidents? Why try to cure or treat any disease? All of these are basically ways to cheat death, at least for awhile.

But again, I want to clarify that my goal with this book isnt to advocate one way or another for outfoxing the grim reaper. I am simply trying to tell the story of these forces and people who are creating profound and fundamental change in the human story. I wanted to tell that tale, not explore the theology and philosophy of life and death because its not about my point of view. Its about whats happening and why its important.

Carnegie Library Lecture HallChip WalterImmortalityInc.National GeographicPittsburgh Arts and Lecture Series

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Chip Walter is dying for you to read his new book on immortality. Or is he? - NEXTpittsburgh

India’s first anti-aging international conference talks of benefits of preventive health. – Daily Pioneer

In order to create awareness about healthy life style, Indias first anti-aging International conference was organized in the National Capital which was attended by more than 300 doctors and featured the most cutting edge and futurists innovations in healthcare.

Preeti Malhotra, president of organising committee said that medicine has taken an exponential leap this century. Preventive health has had a profound effect on human longevity, awareness and mental wellbeing of the people.

I wish more people discover the benefits of preventive health, and can lead happy and healthy lives. This technique has gained attention for its incredible effects on both weight loss and on diseases. Since weight loss is a long journey for some, it is seen quite often that people who opt for healthy lifestyle be it by changing their diet or incorporating exercises in their day to day life, people tend to continue the healthy practice and hence we have seen people continuing the practice. said Dr M (BK Modi) founder and Chairman of Smart Group.

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India's first anti-aging international conference talks of benefits of preventive health. - Daily Pioneer

Over 300 doctors gather in Delhi to emphasize importance of intermittent fasting – Outlook India

New Delhi, Jan 18 (PTI) Over 300 doctors from across the globe congregated in the national capital and emphasised the importance of intermittent fasting as a preventive healthcare to lead a healthy life.

They said practices such as intermittent fasting are known to regulate the lipids in the body thereby maintaining the glycemic index. Apart from being a weight loss remedy, it also helps in developing a more active lifestyle.

Highlighting the ways for healthy living, renowned doctors, healthcare practitioners from India, USA, Canada, China, Vietnam, Australia and South Africa took part in the anti-aging conference.

The highlights of the lecture sessions included discussions on advanced cutting edge technology and futuristic innovations in the healthcare for a better and healthy living.

While medication has taken an exponential leap this century, many people are still unaware that preventive health has had a profound effect on human longevity, awareness, mental wellbeing, BK Modi founder-chairman, Smart Group, said via a video conference.

"I wish more people discover the benefits of preventive health. Though people are becoming very health conscious and hence intermittent fasting is one of the ways that has attracted 30-40% of the people for the same. Seeking the benefits, more number of people are opting, as it not only triggers weight loss but also helps the body to combat various chronic ailments," Modi said.

People are always looking for something new way of losing weight, and intermittent fasting is a very old method used by people for weight loss and body cleansing, another doctor said.

Unless any patient has a history of some chronic disease, diabetes, hypertention etc, people in any age bracket irrespective of gender are recommended.

"It is glad to see that doctors in India are taking a keen interest in preventive health. With the introduction of featured new age topics including intermittent fasting, regenerative medicine, autoimmunity, biochemical detox, and sub-fertile male amongst others, these techniques have gained attention for it''s incredible effects on both weight loss and curbing down chronic diseases," said Micheal Brown, director, American Academy of Anti-Aging Medicine.

The conference was organised by Smart Group, a diversified business conglomerate with interests in mobility, finance, healthcare and technology sectors, in collaboration with American Academy of Anti-Aging Medicine, a not-for-profit medical society dedicated to the detection, prevention and treatment of diseases associated with aging. PTI PLB ABHABH

Disclaimer :- This story has not been edited by Outlook staff and is auto-generated from news agency feeds. Source: PTI

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Over 300 doctors gather in Delhi to emphasize importance of intermittent fasting - Outlook India

Live Longer And Healthier By Regularly Doing This Simple Activity – International Business Times

KEY POINTS

For many years, the human race has been on a quest for ways to improve longevity. Through scientific studies, researchers were able to point out unhealthy practices that you should get rid of to enjoy a longer life. Some of these include quitting smoking as the habit increases your risk of developing several serious ailments like cancer. Although avoiding known unhealthy lifestyle practices play a vital role in achieving longevity, there is a connection between enjoying simple past-times and longevity.

Own a Dog

A new study published in Circulation: Cardiovascular Quality and Outcomes reveals that owning a dog has been associated with living a longer life. It also showed that those who own dogs also have better cardiovascular activities. Those who live alone and have had bouts with a heart attack and stroke are advised to indulge in such activity. dog ownership longevity lifestpan Photo: MabelAmber - Pixabay

The outcome in the published study was based on two other studies, which showed that dog ownership was associated with a reduction in the factors that play a role in cardiac arrest and other heart-related events.

As a result, since cardiac arrest and cardiovascular events are reduced, the mortality rate associated with these diseases is likewise reduced. Although these studies do not necessarily prove that dog ownership is linked to lower mortality rates, the results clearly suggest this.

Other Benefits Of Dog Ownership

According to previous studies, by owning a dog, social isolation is alleviated. It also helps improve physical activity and also helps in lowering blood pressure. They also found that this is very much evident among dog owners as compared to those who dont own one.

The study looked into the data that was provided by the Swedish National Patient Register. Swedish residents aged between 40 to 85 years old became part of the study. They were the ones who experienced a stroke or a heart attack.

Out of these residents, it was found that those who owned a dog were said to have a lower risk of death thereafter. The possible reasons pointed out include decreased loneliness and depression. They also had better socialization because of their dogs. Furthermore, it was found that by owning a dog, they are better motivated to keep themselves active and physically fit.

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Live Longer And Healthier By Regularly Doing This Simple Activity - International Business Times

The human body isn’t running at 98.6 degrees anymore. (And it hasn’t been for 150 years.) – The Daily Briefing

The average human body temperature has steadily declined since the 19th century, according to a study published earlier this month in eLife, raising questions about whether the "normal" human body temperature is actually lower than 98.6 degrees Fahrenheit, Nicholas Bakalar reports for the New York Times' "Well."

According to researchers, the common claim that human body temperature averages 98.6 degrees Fahrenheit originated with a study by the German doctor Carl Reinhold August Wunderlich, who repeatedly measured the temperatures of 25,000 people in Leipzig in 1851. But researchers questioned whether that data truly represented average body temperature in the modern age.

To find out, they examined 677,423 human body temperature measurements from three databases to determine how body temperatures have changed over time. Human body temperatures serve as "a crude surrogate for basal metabolic rate which, in turn, has been linked to both longevity (higher metabolic rate, shorter life span) and body size (lower metabolism, greater body mass)," the researchers noted.

The databases spanned 157 years of measurement. The first database contained temperature readings obtained from 23,710 Civil War veterans between 1862 and 1930. The second database contained temperatures readings for 15,301 individuals collected by CDC's National Health and Nutrition Examination Survey from 1971 to 1975. The third database contained temperature readings for 150,280 individuals collected by the Stanford University from 2007 to 2017.

Overall, the researchers found the average human body temperature has decreased by 0.03 degrees centigrade, or about 0.05 degrees Fahrenheit, per birth decade. Pointing to the findings, Bakalar in the writes, "Today, a temperature of 97.5 may be closer to 'normal' than the traditional 98.6."

According to the researchers, "men born in the early 19thcentury had temperatures 0.59C higher than men today, with a monotonic decrease of 0.03C per birth decade." Meanwhile, women's average body temperatures have decreased by 0.32C since the 1890s, at a similar rate of 0.029C per birth decade.

The researchers said the decline in the average human body temperature could not be explained by differences in measurement techniques. They explained that the decrease in average body temperature occurred annually within each of the three databases and that they found identical declines between the two modern databases, which presumably involved the same equipment and measurement techniques.

While it's unclear what drove the decline in body temperatures, the researchers did offer a few possible explanations. Namely, the researchers pointed to advancements in heating and air conditions, which help maintain constant temperatures; reductions in chronic inflammation; and improvements in dental care, medical care, and sanitation.

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The human body isn't running at 98.6 degrees anymore. (And it hasn't been for 150 years.) - The Daily Briefing

NSF grant funds research to study nature-based solutions for river restoration – Penn State News

UNIVERSITY PARK, Pa. As communities look to restore their waterways after centuries of human alteration, many are turning to nature for inspiration.

River restoration projects utilizing nature-based solutions, like the Big Spring Creek restoration project in Cumberland County, Pennsylvania, revitalize their ecosystems by reintroducing natural materials like wood and debris into their design. These materials over time often amass into complex, porous structures that offer many ecological benefits but are not well understood, according to Xiaofeng Liu, associate professor of civil engineering and co-hire of the Institute of Computational and Data Sciences at Penn State.

Thanks to a $297,791 grant from the National Science Foundation, Liu will examine the nature-based solution of engineered log jams to quantitively describe the flow and sediment dynamics around these systems.

Xiaofeng Liu, associate professor of civil engineering

These are expensive projects, but theres not too much of a scientific understanding of what really is going on, Liu said. How does the water move around the in-stream structures? How does it carry solute and sediment?

In contrast to restoration projects that use concrete and steel, water and sediment are able to flow through the pores in the nature-mimicking structure, creating unique turbulent flow patterns.

The porosity creates more complexity and richness in the flow features, Liu said. Water can go through them and around them. This complex flow field is important for the functionality and longevity of the structure.

As these flow patterns develop, sediment is transported and sometimes filtered by the wood and debris. This sediment movement around the log jam can also result in scour holes that can become habitats and shelters for fish, a desirable characteristic of nature-based solutions. However, Liu noted, these holes develop differently than they would around traditional impervious structures, such as bridge piers, and can have an effect on the longevity of the structure.

For engineers looking to install an engineered log jam, the lack of fundamental understanding of these complex flow patterns means relying on educated guess. Formulas that currently exist to predict scour hole size and depth do not account for porosity.

Its a lot of trial and error at this stage right now, Liu said.

Based on preliminary results, Liu developed his own formula using porosity as a parameter to help predict scour hole size for nature-based solutions. He will test this by developing a high-fidelity 3D model to simulate the flow and sediment dynamics in a river containing an engineered log jam.

Mathematically resolving all of the geometric details found in an engineered log jam requires a lot of computing power, so Liu will rely on the ICS-ACI, Penn States high-performance research cloud, to run the simulations.

The mathematical equations in the model are just the descriptions of the physical processes in this problem, Liu said. Flow carries the sediment and creates a hole. When holes are enlarged, water has more space to go. Our model describes this co-evolution with the presence of a complex restoration structure.

Liu will also run physical experiments in a 15-meter flume, an artificial water channel in the Penn State Hydraulics Laboratory, using scaled-down engineered log jam models. After each experiment, he will drain the flume and use a laser to scan the bed. The results of the flume experiments will then be cross-referenced with the computational model and with field measurements to validate results.

If Liu succeeds and is able to establish a fundamental understanding of the physical processes occurring around these structures, future research will then be able to link that to ecological processes, which should give scientists a better idea of how well these solutions are achieving their sustainability goals.

Thats the final goal, Liu said. Hopefully, with the introduction of nature-based solutions, nature can start to re-establish itself. When nature is working, you dont need too much human intervention.

Last Updated January 16, 2020

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NSF grant funds research to study nature-based solutions for river restoration - Penn State News

NMN Benefits – The Path of Longevity – ProHealth

Gauging the benefits of NMN, or any supplement, medicine, or treatment regimen can be a bit tricky if done without the benefit of scientific methods and testing standards.

Treatments, and human perception itself, can be influenced by several factors. If we make changes to our diet or lifestyle routine while using a particular herb or vitamin, for example, was it the supplement that produced the perceived effects, or was it those salads?

Perhaps it was just our own mind, convinced that the supplement would produce a particular benefit. This mental ability to influence a treatment regimens outcome is called the placebo effect. The placebo effect can account for a large portion of any treatments success or failure, which is why many research studies are designed to minimize it.

Another dynamic at play to consider is a persons perception and evaluation of a particular treatment, called anecdotal evidence. Anecdotal evidence, while not considered reliable by scientists, is nonetheless a common feature of day-to-day health care. If your doctor prescribes a medicine or supplement, and then later asks, What happened?, he or she is asking for anecdotal evidence

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NMN Benefits - The Path of Longevity - ProHealth

12 Must-See Exhibitions This Week, from San Francisco to Paris and Beyond – Surface Magazine

ITINERARY Justin Matherly's contorted sculptures, Doug Wheeler's deep dives into light and space, Madeline Hollanders luminous Bortolami debut, and more. THE EDITORS January 20, 2020

When: Jan. 8Feb. 22

Where: Demisch Danant, New York

What: In the 1960s and 70s, French design took a turn toward rounded forms, saturated colors, and a medley of textures that designers such as Pierre Paulin and Olivier Mourgue playfully employed to soften the severity of modern architecture. Color Diaries riffs on this humanization by presenting a curated color field in three-dimensional soft forms, encouraging visitors to engage in color play guided by none other than their own personal associations.Ryan Waddoups

When: Jan. 10Feb. 22

Where: Bortolami, New York

What: Over the past few years, Madeline Hollander has choreographed bewitching, systems-based dance pieces that have established her as one of the most whip-smart artists in town, and also one of the most thrilling. (A memorable 2018 piece had four performers enacting intricate, athletics-inspired moves until they raised the heat in the room enough to activate air conditioners. When the temperature dropped sufficiently, they went at it again.) For her Bortolami debut, Hollander is working with objects instead of humans, programming scores of car headlights and taillights to respond to the traffic light at the nearby intersection. When that light goes red, the taillights come alive in a sea of disparate sequences that she has conceived, imagining drivers stuck in traffic. Transposing peoples everyday actions into a symphonic light work, the piece is uncanny and oddly moving. It seems likely to become even more so. Once the driverless car competition is won, the wildly blinking field will be a memorial to one more form of human control that has been replaced by machines.Andrew Russeth

When: Jan. 11Feb. 15

Where: Modern Art, London

What: The interlocking figures that populate Paul Mpagi Sepuyas photographs are his close companions: friends, lovers, or fellow queer artists interlocking with fragments of his own body. For the artists first solo exhibition in the U.K., presented in collaboration with New Yorkbased Team Gallery, a series of recent visuals range from close-up mirror portraits of tangled limbs to self-reflexive collages, conveying his sensitivity and skill in capturing bodies on camera.Ryan Waddoups

When: Jan. 12Feb. 23

Where: Magenta Plains, New York

What: Growing up in Arendal, Norway, about three hours southwest of Oslo by car, the artist Tiril Hasselknippe watched a lot of nature documentaries. One program, focused on a volcano whose eruption was 100 years overdue, convinced her that the end was near, and she has held onto that apocalyptic worldview. Thats just how Im wired, the 35-year-old says, sitting in the Magenta Plains gallery in New York, where her latest solo show just went on view. Much of her work, which has appeared in the 2018 New Museum Triennial and shows at kunsthalles across Europe, could be seen as attempts to stave off or mitigate such disastertheyre scrappy, hand-fashioned solutions to potential catastrophes.Tiffany Jow

When: Jan. 16Feb. 15

Where: The Future Perfect, San Francisco

What: As FOG Design+Art kicks off in San Francisco, the Los Angelesbased ceramist Bari Ziperstein is presenting her Tube collection, a line of new and exclusive ceramic pieces, in her first solo exhibition at The Future Perfects Bay Area outpost. The work on view riffs on an industrial tube, curving, cutting, and combining different versions of the cylindrical shape in artful, unexpected ways.Tiffany Jow

When: Jan. 16Feb. 22

Where: Lehmann Maupin, New York

What: Erwin Wurms One Minute Sculptures are everyday objects accompanied by instructions that tell viewers how to interact with them (usually in ways that are playful and absurd). The artist, whos been experimenting with video, performance, installation, and other mediums for more than three decades, will present a series of new sculptures in this exhibition. One piece, One Minute forever (hands/fruits) (2019), consists of a concrete cast hand with oranges pushed onto its fingertipsan act that prolongs Wurms participatory project for eternity.Tiffany Jow

When: Jan. 17April 30

Where: Carpenters Workshop Gallery, San Francisco

What: The Dutch design duo known for ambitious projects and asking really big questions scales things up even more with About Nature, Technology, and Humankind, which marks the largest installations to date of their seminal works Flylight and Fragile Future III in the United States. Both works, which showcase how artists utilize cutting-edge technology to mimic existing natural phenomena such as the flight patterns of birds and longevity of dandelions, are presented during a time of dire environmental turmoil that beckons new scrutiny of the sustainability of human progress.Ryan Waddoups

When: Jan. 22March 7

Where: Gladstone Gallery, Brussels

What: One of the standout participants in the central show of the 2019 Venice Biennale, the Paris-based artist Cameron Jamie makes figures and masks in a panoply of mediums (glazed stoneware, most famously) that are fearsome, inventive, and often discomfitingly familiar; they suggest dark emotions and unsettled states of mind. For his first exhibition at Gladstones stately Brussels branch, Jamie is presenting what the enterprise is terming a rogues gallery of ceramic masks. Some are faced away from the viewer, a signature move that the artist seems to use to invite viewers to venture into the alternate states that he conjures, or simply to embody the hidden ones that he recognizes in us all.Andrew Russeth

When: Jan. 23April 18

Where: Storefront for Art and Architecture, New York

What: Julia Morgan (18721957) was the first female architecture student at the Paris in cole des Beaux-Arts and later became a proponent of the American Arts and Crafts movement. Jules Bourgoin (18381908) was a Paris-born professor at the institution who spent time exploring the Middle East and North Africa, intricately documenting the ornate structures he encountered. While Bourgoins exact impact on his students is not known, the Beirut-based artist Rayyane Tabet juxtaposes their work in this exhibition, prompting viewers to consider notions of appropriation and context. Tiffany Jow

When: Jan. 24March 21

Where: David Zwirner, New York

What: Though he began his career as a painter, Doug Wheeler quickly became fascinated with light, incorporating actual bulbs into his wall-mounted artworks and then a light environment inside his Venice Beach studio in 1967. Since then, the American artist has realized ethereal luminous environments at the Guggenheim, Hirshhorn, and Stedelijk museums, which fellow artist Daniel Buren has likened to experiencing a spatial event, entering into light. Wheelers latest exhibition, which takes over David Zwirners 19th Street gallery, continues his lifelong study of lights atmospheric and perceptual effects. Ryan Waddoups

Jan. 25March 14

Galerie Eva Presenhuber, Zurich

American artist Justin Matherly uses Greek and Roman antiquity as a jumping-off point for his weird, contorted sculptures. This exhibition presents new work that showcases his interest in statues, columns, and reliefs as well as his production process, in which forms are first carved out of XPS insulation foam then cast in concrete, gypsum, or fiberglass resin. Tiffany Jow

More here:
12 Must-See Exhibitions This Week, from San Francisco to Paris and Beyond - Surface Magazine

The secret of Homo sapiens evolution? Migration, diversity, mixing – and meaning – Pressenza, International Press Agency

In tandem with attempts to resist the waves of migration produced by wars, poverty and climate change humanity has been on a quest to find the first, unique modern human, a mitochondrial Eve from which we are all descendants. But the big surprise has been that although there is little doubt that humans originally evolved in Africa, genetic analysis points out rather to groups that separated for different reasons, evolved genetically and culturally in different directions and then came back together mixing both the genetic material and the newly acquired skills. The common ancestors of todays modern humans lived a lot earlier than it was thought and science is leaving the door open for even older findings as the fossil register shows an incomplete picture.

For example, a 2017 finding in Morocco threw into question the idea that modern humans originated in East Africa. Those bones were significantly older than any others ever found.

Researchers determined that the bones unearthed in Moroccos Jebel Irhoud region are 315,000 years old roughly 100,000 older than the bones previously considered oldest modern human fossils. (Those fossils, found in Ethiopia, were roughly 196,000 years old.)

The remains were also found in a different area of Africa than most other ancient human bones: North Africa instead of East Africa. That suggests our earliest ancestors may not have lived in just one part of the continent.

There is no Garden of Eden in Africa, or if there is, it is all of Africa, anthropologist Jean-Jacques Hublin, who led the Morocco expedition, said at the time.

Silo described evolving systems that go through stages of differentiation, complementation and synthesis, before moving to a new differentiation. Here we seem to have a rather nice example.

Furthermore, genetic analysis has revealed that the ancestors of modern humans interbred with at least five different archaic human groups as they moved out of Africa and across Eurasia. According to Dr Joo Teixeira, Australian Research Council Research Associate, ACAD in Science Daily.

While two of the archaic groups are currently known the Neanderthals and their sister group the Denisovans from Asia the others remain unnamed and have only been detected as traces of DNA surviving in different modern populations. Island Southeast Asia appears to have been a particular hotbed of diversity.

There was an evolutionary leap in those first humans, perhaps accelerated by the merging of the diverging hominid/human groups and exposure to different environments through migration. Learning to use fire initiated the technological revolution of changing materials found in nature, such as clay, ore and sand into other materials with different properties, such as ceramics, metals and glass. At the same time a revolution of consciousness was taking place, that changed the whole society through collective communication, starting from pictorial representations that eventually led to the principles of written language, showing the evidence for evolving abstract thinking paired with allegorical mental processes that seem to have promoted also the development of a spiritual drive. So humans were no longer brought up mainly in a natural environment but rather in a cultural one, that is, historical/social. This accelerated evolution beyond anything seen in nature before. The initial spark of intentionality, the capacity to structure the world and thinking in an intentional way, grew and continued acting from the depths of human consciousness pushing the species towards achievements and transformations without any limits, sketching the first questions about meaning. And this takes us to today.

Humanity 2.0 approaching

We are again, like our ancestors, distributed around large geographical areas, divided into nations, races, ethnic groups and corporations, all competing for resources. Two opposing tendencies serve as the backdrop of todays human relationships. On the one hand the nationalistic, racist, white supremacist, anti immigration ideologies with their many levels from the mildly fearful following right wing populist leaders to the frankly active neonazis. On the other hand we have the progressives, welcoming diversity and immigration, promoting solidarity, human rights, equality, the protection of the environment and searching from a new economic system away from destructive capitalist neoliberalism. In between all possible shades and combinations. Polarisation grows at the time of elections and other political crises thanks to the rhetoric of the power-thirsty leaders and softens up during events that bring people together.

But the profound search for meaning, for that which helps us make sense of our own existence continues through the waxing and waning of external events, violence, preposterous leaders and our apparently incomprehensible small place in the Universe.

In this way humanity is preparing itself for its next evolutionary leap which is likely to take place when all humans are connected and nobody is left out of the inspirational wave that shook our ancestors and set the spark of intentionality in their psyches circa 300,000 years ago.

We dont know when this will happen but we can see how the horror of the violence unleashed but certain actors, those who dehumanise others and impose draconian conditions, often work as awakeners. But the green shoots of a new sensibility can be seen everywhere, in new political thinking, in youth movements, in a new spirituality based on experience rather than belief and away from the dogma of old religions, in a search for meaning in life.

A few days ago Pressenza published a comprehensive presentation about the Psychology of New Humanism by Victor Piccininni. He states that This process does not stop and it is perhaps in 1945, with the developments of Victor Frankl, creator of Logotherapy, that it finds its highest dimension. In his work Frankl highlights the spiritual dimension of the human being and stresses that it is the lack of meaning that is the main root of human suffering. This psychotherapy of the meaning of life is based on an active consciousness in search of meaning.

Coincidentally (or not?) the theme kept turning up in different unrelated publications

Steve Taylor ,Senior Lecturer in Psychology, Leeds Beckett University writing for The Conversation posits that Human life is not a meaningless space between birth and death, spent trying to enjoy ourselves and forget about our predicament. I believe that human life and the world mean much more than that. And this is not because I am religious I am not.

Instead, my perspective is informed by my scientific research over the past ten years with people who have undergone what I call suffering-induced transformational experiences.

These experiences include being diagnosed with terminal cancer, or suffering bereavements, or becoming seriously disabled, or losing everything through addiction or having close encounters with death during combat.

What all these people had in common is after undergoing intense suffering, they felt they had woken up. They stopped taking life, the world and other people for granted and gained a massive sense of appreciation for everything.

They spoke of a sense of the preciousness of life, their own bodies, the other people in their lives and the beauty and wonder of nature. They felt a new sense of connection with other people, the natural world and the universe.

They became less materialistic and more altruistic. Possessions and career advancement became trivial, while love, creativity and altruism became much more important. They felt intensely alive.

In this case the awakeners were not obnoxious sociopathic politicians but personal suffering. It is indeed of great interest to discover that crises can lead to new meanings, but we also need to be careful not to extol suffering in itself, and promote it as something good for the soul that we should seek even when things are OK.

Another perspective on the theme of meaning comes from a study published by Science Daily which examines meaning in life and its relationship with physical, mental and cognitive functioning: Over the last three decades, meaning in life has emerged as an important question in medical research, especially in the context of an ageing population. A recent study by researchers at University of California San Diego School of Medicine found that the presence of and search for meaning in life are important for health and well-being, though the relationships differ in adults younger and older than age 60.

Many think about the meaning and purpose in life from a philosophical perspective, but meaning in life is associated with better health, wellness and perhaps longevity, said senior author Dilip V. Jeste, MD, senior associate dean for the Center of Healthy Aging and Distinguished Professor of Psychiatry and Neurosciences at UC San Diego School of Medicine. Those with meaning in life are happier and healthier than those without it.

The results also showed that the presence of meaning in life exhibited an inverted U-shaped relationship, while the search for meaning in life showed a U-shaped relationship with age. The researchers found that age 60 is when the presence of meaning in life peaks and the search for meaning of life was at its lowest point.

When you are young, like in your twenties, you are unsure about your career, a life partner and who you are as a person. You are searching for meaning in life, said Jeste. As you start to get into your thirties, forties and fifties, you have more established relationships, maybe you are married and have a family and youre settled in a career. The search decreases and the meaning in life increases.

After age 60, things begin to change. People retire from their job and start to lose their identity. They start to develop health issues and some of their friends and family begin to pass away. They start searching for the meaning in life again because the meaning they once had has changed.

Although showing the connection between meaning and health is extremely important, in this case researchers have equated meaning in life with what the Psychology of New Humanism has described as provisional meanings: people. objects, jobs, that may be temporary, ephemeral. In the words of the old Sufi saying, we possess only that we cannot lose in a shipwreck. The presence of a deeper and more permanent meaning guides a different search opening up to other regions of human consciousness.

Kenan Malik for The Observer makes comparisons between uber Christian 17th Century John Miltons Paradise Lost and its less than holy 20th Century counterpart, Philip Pullmans His dark materials. He concludes Reasoned argument and clarity are an indispensable part of our quest for knowledge. So are stories and their ambiguities. They are a celebration of the human capacity to find meaning and a recognition that meaning is not something to be discovered but something that humans create. From Adam and Eve to Lyra and Will*, it is that search for meaning that enchants, excites, moves and inspires.

Perhaps what is missing from this potpourri of views about meaning and how to get it- wholly understandable in our individualistic society- is that meaning is connected to the sense of internal unity and coherence arising from helping others. Many celebrities, to their own surprise, have discovered meaning in empathising and developing acts of solidarity towards others, something ordinary people are much more aware of.

In spite of the efforts of anti migration forces humanity is again mixing, coming together with its new complexity and different paths to answer the great questions. There has been a long period of differentiation and a new complementation is in motion. This convergence of diversity is at the root of the new leap we are about to take, no matter how solid the meaningless dehumanising system appears to be.

* His dark materials characters

Continued here:
The secret of Homo sapiens evolution? Migration, diversity, mixing - and meaning - Pressenza, International Press Agency

Illuminating the Hidden Forest, Chapter 29: Trees and the art of aging | – theberkshireedge.com

To read the previous chapters of Illuminating the Hidden Forest,click here.

Jan. 16, 2020

Scientists have recently discovered ginkgo trees more than 600 years old in China. This is very old for a tree, even for a tree whose forebears have been around for 2,000 years. They asked, What kept this tree alive for so long, and could it possibly live forever?

What the biologists discovered is that the trees cambium, the active vascular layer beneath the bark, can continue making new cells indefinitely. The cambium of these ancient trees look as youthful and healthy as trees say, 560 years younger.

This is not to say that trees dont die. Forest floors are littered with dead and decaying trees, downed by wind, lightning, bugs, fire, arboreal disease and other falling trees, not to mention overlogging. But it does suggest that in the absence of human and natural threats to arboreal life, trees dont necessarily decline with age. The cambium can maintain the vital forces of life even as the body of the tree decays around it.

A hollowed living tree, photo by Carolyn Newberger

In my walks in the woods, I sometimes come across large and venerable trees with cracked and hollowed trunks that, in season, carry leafy canopies above. In such a tree behind my house, in pensive moments, I stand inside the trunk with my ear to the cambium and listen for what I dont know, but I seem to find serenity inside that ancient mother tree, who continues to generate life and growth despite age and injury.

We humans and other creatures of the animal and insect world, it seems, are programmed to decline in age. But is our decline inevitable? In some ways we share characteristics with trees. A vascular system carries moisture and nutrients through our bodies. A skin that protects our insides from the outside world surrounds us. Of course, were also different in countless ways, but as with the trees cambium, we have one organ that drives the work of our human body. Curiously, that organ shares a name with the tree.

The outside layer of our brains, cortex, is Latin for bark. Cerebral cortex is the bark of the brain. Rather than insulate the brain from the outside world as bark does for the tree, however, our cortex is the largest site of neural integration in the central nervous system, functionally more akin to a trees cambium than to its enveloping bark.

Remarkably, the likeness to a trees cambium doesnt end there. The cortex and other parts of the brain continue to generate new cells and connections throughout life, even into our 80s and 90s. A 78-year-old (like me!) can have as many young neurons as a 20-year-old. In addition, he or she has a wealth of memories to draw from (perhaps helping to explain a longer retrieval time) and of life experiences to understand and interpret what life has to offer. In other words, older people cannot only stay smart, they can become wiser. Mental decline in a healthy nonagenarian is not a given. Yet even if the minds decline isnt inevitable, it needs to be fed. Reading, thinking, debating, hearing new songs, savoring new tastes and meeting new people in new places can all feed the neuronal generation that helps keep our brains young and healthy.

As I reflect from my niche inside the ancient tree behind my house, the tree seems to be hugging me. I feel a spiritual connection not only with this patient and enduring soul, but also with the forest and, as well, with the universe of living things beyond. We all grow old. Someday we shall all die, even the gingkoes persisting through the centuries.

Yet while we are here, we can cherish the intelligence and endurance that keeps life pulsing on. We must protect the resources to feed, sustain and develop the life the ginkgoes and we are privileged to enjoy. That means not only taking care of our bodies, but also taking care of the planet that sustains us all, from the forests to the oceans, from the rivers to the plains, from the mountains to the valleys and to all their inhabitants.

To read more about the gingkoes and our regenerating brains, here are some references:

Multifeature analyses of vascular cambial cells reveal longevity mechanisms in oldGinkgo bilobatrees, Li Wang,et al., Proc Natl Acad Sci USA, Jan. 13, 2020.

Casella, Carly, https://www.sciencealert.com/this-ancient-tree-species-is-virtually-immortal-and-we-finally-understand-how

NIH Directors Blog, https://nih.gov/2018/04/10/new-evidence-suggests-aging-brains-continue-to-make-new-neurons/

Daniel Levitin, Everyone Knows Memory Fails as You Age. But Everyone is Wrong, NYTimes, Jan. 10, 2020, https://nyti.ms/2scpG4J

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Illuminating the Hidden Forest, Chapter 29: Trees and the art of aging | - theberkshireedge.com

Looking for answers in the circadian rhythm – The Week Magazine

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Long before Apple watches, grandfather clocks or even sundials, nature provided living things with a way to tell time.

Life evolved on a rotating world that delivered alternating light and darkness on a 24-hour cycle. Over time, cellular chemistry tuned itself to that rhythm. Today, circadian rhythms governed by a master timekeeper in the brain guide sleeping schedules and mealtimes and influence everything from diet to depression to the risk of cancer. While an Apple watch can monitor a few vital functions such as your heart rate, your body's natural clock controls or affects nearly all of them.

"Circadian rhythms impact almost every aspect of biology," says neuroscientist Joseph Takahashi of the University of Texas Southwestern Medical Center.

Lately, research by Takahashi and others has suggested strategies for manipulating the body's clock to correct circadian-controlled chemistry when it goes awry. Such circadian interventions could lead to relief for shift workers, antidotes for jet lag, and novel treatments for mood disorders and obesity, not to mention the prospect of counteracting aging.

Prime weapons for the assault on clock-related maladies, Takahashi believes, can be recruited from an arsenal of small molecules, including some existing medical drugs.

"Researchers are increasingly interested in developing small molecules to target the circadian system directly for therapeutic gains," Takahashi and coauthors Zheng Chen and Seung-Hee Yoo wrote in the 2018 Annual Review of Pharmacology and Toxicology.

In sophisticated life-forms (such as mammals), central control of the body's clock resides in a small cluster of nerve cells within the brain's hypothalamus. That cluster, called the suprachiasmatic nucleus SCN for short is tuned to the day-night signal by light transmitted via the eyes and the optic nerve.

But the SCN does not do the job alone. It's the master clock, for sure, but satellite timekeepers operate in all kinds of cells and body tissues.

"There isn't just an SCN clock in the brain," Takahashi said at a recent meeting of the Society for Neuroscience. "There are clocks throughout the entire body. Every major organ system has its own intrinsic clock."

The proliferation of clocks throughout the body makes circadian chemistry relevant to various behaviors and physiological processes, such as metabolism and blood flow. Maintaining healthy physiology requires all the body's various clocks to be synchronized by signals (in the form of hormones and nerve impulses) from the SCN. SCN signals govern the timing of genetic activity responsible for the production of numerous clock-related proteins. Studies mainly in mice have shown how those proteins participate in complex chemical feedback loops, perpetuating rhythmic genetic activity in which proteins are first produced and then degraded to drive circadian cycles. Similar chemistry operates in humans.

Key molecular players in keeping the body's clocks ticking are the proteins known as CLOCK and BMAL1. Studies of liver cells in mice show that CLOCK partners with BMAL1 to regulate gene activity, driving all the important circadian chemical reactions. "Generally in many cells you see a similar kind of picture, in the brain or other tissues," Takahashi said.

The CLOCK-BMAL1 tandem activates genes that produce several forms of the circadian proteins period and cryptochrome. In mice, that process starts work in daytime, leading to a substantial buildup of period (PER) and cryptochrome (CRY) by evening. At night, PER and CRY migrate into the cell's nucleus and block the action of CLOCK-BMAL1, thereby halting production of PER and CRY themselves. PER and CRY amounts then diminish as other molecules degrade them. By morning, PER and CRY levels drop so low that CLOCK and BMAL1 are no longer disabled and can begin producing PER and CRY anew.

Many other molecules participate in circadian chemistry; the exact molecular participants differ from tissue type to tissue type. In the (mouse) liver alone, the activity of thousands of genes fluctuates on a circadian schedule.

An hourglass uses the flow of sand to mark time. The body uses the build-up and flow of proteins to keep its rhythms. Although there are numerous different players in the bodys many clocks, the workings of the circadian proteins period (PER) and cryptochrome (CRY) (and their counterparts CLOCK and BMAL1) exemplify the kind of feedback loop that keeps the body in sync with the day-night cycle.

While signals from the SCN set the daily schedule for circadian chemistry, various small molecules, such as many medicinal drugs, can disrupt cellular timing. (That's one reason certain drugs such as blood thinners and chemotherapy treatments are more or less effective depending on the time of day that they are administered.) Researchers have identified dozens of small molecules that can influence circadian processes.

Some such molecules change the length of the circadian period. Some alter the precise timing of specific processes during the cycle. Others help maintain robust signals for synchronizing the body's clocks. Circadian signaling weakens with age, possibly contributing to many age-related disorders such as impaired metabolism or sleep problems.

Among the common drugs that exert effects on the circadian system are opsinamides, sulfur-containing compounds that suppress the amount of light input into the SCN. Nobiletin, found in the peels of citrus fruits, manipulates circadian rhythms to improve metabolism in obese mice. (Nobiletin also counters tumors and inflammation.) Resveratrol is a well-known compound that alters the activity of certain clock genes, with some possible human health benefits.

Scientists have discovered a long list of existing medicines and small molecules now under investigation that act on or influence the bodys circadian system.

Today's challenge, Takahashi and coauthors say, is to identify the precise targets where small molecules exert their influence. Knowing the targets should help researchers find ways to repair defects in the circadian system or alleviate temporary inconveniences such as jet lag.

Jet lag occurs when sudden changes in time zone generate a mismatch between the body clock's expectations and the actual day-night cycle (not to mention timing of meals and social activities). While it is usually just an annoyance for travelers, shift workers face long-term consequences for working when the body clock advises sleep. Shift workers, Chen, Yoo, and Takahashi point out, are at risk for sleep problems, gastrointestinal disorders, obesity, cardiovascular disease, cancer and mood disorders. Molecules tested in mice have shown promise for reconciling expectations with reality, getting the clock back in phase with the body's environment.

Clock malfunction also affects the body's disease-fighting immune system, and certain clock components have been identified as potential targets for alleviating autoimmune disease and excessive inflammation. Other recent studies have shown that molecular intervention with clock components can aid proper functioning of mitochondria, the cellular structures responsible for energy production.

While most of the details about circadian chemistry come from studies in mice, studies of human sleep disorders indicate that the basic circadian story is similar in people. A mutation in the human gene responsible for making one of the period proteins has been linked, for example, to familial advanced sleep phase disorder. (In people with that mutation, the normal sleep-wake cycles shift by several hours.) Other research has shown that a variant version of the human gene for cryptochrome protein increases the risk of diabetes.

An especially intriguing possibility is that body clock management could provide strategies for slowing down aging.

Many studies have shown that aging in some animals can be slowed by restricting food intake. Fewer calories can lead to longer lives. But work by Takahashi and others has found that (in mice, at least) timing of ingesting the calories can be almost as important as the quantity.

Mice allowed to eat a normal amount of calories, but only within restricted hours, have lived about 15 percent longer than usual, Takahashi reported at the neuroscience meeting. In humans, that would correspond to a life span increase from 80 years to 92.

"We're super excited about these results, because these are the first experiments to show that you can extend life span by restriction of time of nutrient intake only without a reduction of calories," Takahashi said.

"For us it's much easier to restrict the time that we eat than the amount that we eat. Now if you can do both, that's even better. I think that this, I hope, could have benefit for human health and longevity in the future."

This article originally appeared in Knowable Magazine, an independent journalistic endeavor from Annual Reviews. Sign up for the newsletter.

Continue reading here:
Looking for answers in the circadian rhythm - The Week Magazine

Here’s What Meat-Eaters Really Think of Veganism, According to a New Study – ScienceAlert

Most people in the UK are committed meat eaters but for how long? My new research into the views of meat eaters found that most respondents viewed veganism as ethical in principle and good for the environment.

It seems that practical matters of taste, price, and convenience are the main barriers preventing more people from adopting veganism not disagreement with the fundamental idea.

This could have major implications for the future of the food industry as meat alternatives become tastier, cheaper and more widely available.

My survey of 1,000 UK adult men and women found that 73 percent of those surveyed considered veganism to be ethical, while 70 percent said it was good for the environment.

But 61 percent said adopting a vegan diet was not enjoyable, 77 percent said it was inconvenient, and 83 percent said it was not easy.

Other possible barriers such as health concerns and social stigma seemed not to be as important, with 60 percent considering veganism to be socially acceptable, and over half saying it was healthy.

The idea that most meat eaters agree with the principles of veganism might seem surprising to some. But other research has led to similar conclusions. One study for example, found that almost half of Americans supported a ban on slaughterhouses.

The prevalence of taste, price, and convenience as barriers to change also mirrors previous findings. One British survey found that the most common reason by far people gave for not being vegetarian is simply: "I like the taste of meat too much." The second and third most common reasons related to the high cost of meat substitutes and struggling for meal ideas.

These findings present climate and animal advocates with an interesting challenge. People are largely aware that there are good reasons to cut down their animal product consumption, but they are mostly not willing to bear the personal cost of doing so.

Decades of food behaviour research has shown us that price, taste and convenience are the three major factors driving food choices. For most people, ethics and environmental impact simply do not enter into it.

Experimental research has also shown that the act of eating meat can alter peoples' views of the morality of eating animals. One study asked participants to rate their moral concern for cows. Before answering, participants were given either nuts or beef jerky to snack on.

The researchers found that eating beef jerky actually caused participants to care less about cows. People seem not to be choosing to eat meat because they think there are good reasons to do so they are choosing to think there are good reasons because they eat meat.

In this way, the default widespread (and, let's be honest, enjoyable) behaviour of meat eating can be a barrier to clear reasoning about our food systems. How can we be expected to discuss this honestly when we have such a strong interest in reaching the conclusion that eating meat is okay?

Fortunately, things are changing. The range, quality, and affordability of vegan options has exploded. My survey was conducted in September 2018, a few months before the tremendously successful release of Greggs' vegan sausage roll.

Since then, we have seen an avalanche of high-quality affordable vegan options released in the British supermarkets, restaurants and even fast food outlets. These allow meat eaters to easily replace animal products one meal at a time.

When Subway offers a version of its meatball marinara that is compatible with your views on ethics and the environment, why would you choose the one made from an animal if the alternative tastes the same?

The widespread availability of these options means that the growing number of vegans, vegetarians and flexitarians in the UK have more choice than ever. Not only will this entice more people to try vegan options, but it will make it far easier for aspiring vegetarians and vegans to stick to their diets.

With consumer choice comes producer competition, and here we will see the magic of the market. If you think those looking to cut down their meat consumption are spoilt for choice in 2020, just wait to see the effect of these food giants racing to make their vegan offerings better and cheaper as they compete for a rapidly growing customer segment.

We may be about to witness an explosion in research to perfect plant-based meat analogues. Meanwhile, the development of real animal meat grown from stem cells without the animals is gaining pace.

While these replacements get tastier, more nutritious and cheaper over the next ten years, meat from animals will largely stay the same. It is no wonder the animal farming industry is nervous. Demand for meat and dairy is falling drastically while the market for alternatives has skyrocketed.

In the US, two major dairy producers have filed for bankruptcy in recent months, while a recent report estimated that the meat and dairy industries will collapse in the next decade.

This leaves the average meat eater with a dilemma. Most agree with the reasons for being vegan but object to the price, taste, and convenience of the alternatives.

As these alternatives get cheaper, better and more widespread, meat eaters will have to ask themselves just how good the alternatives need to be before they decide to consume in line with their values. Being one of the last people to pay for needless animal slaughter because the alternative was only "pretty good" will not be a good look in the near future.

Chris Bryant, PhD Candidate, University of Bath.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Opinions expressed in this article don't necessarily reflect the views of ScienceAlert editorial staff.

Read more:
Here's What Meat-Eaters Really Think of Veganism, According to a New Study - ScienceAlert

What meat eaters really think about veganism new research – The Conversation UK

Most people in the UK are committed meat eaters but for how long? My new research into the views of meat eaters found that most respondents viewed veganism as ethical in principle and good for the environment.

It seems that practical matters of taste, price, and convenience are the main barriers preventing more people from adopting veganism not disagreement with the fundamental idea. This could have major implications for the future of the food industry as meat alternatives become tastier, cheaper and more widely available.

My survey of 1,000 UK adult men and women found that 73% of those surveyed considered veganism to be ethical, while 70% said it was good for the environment. But 61% said adopting a vegan diet was not enjoyable, 77% said it was inconvenient, and 83% said it was not easy.

Other possible barriers such as health concerns and social stigma seemed not to be as important, with 60% considering veganism to be socially acceptable, and over half saying it was healthy.

The idea that most meat eaters agree with the principles of veganism might seem surprising to some. But other research has led to similar conclusions. One study for example, found that almost half of Americans supported a ban on slaughterhouses.

The prevalence of taste, price, and convenience as barriers to change also mirrors previous findings. One British survey found that the most common reason by far people gave for not being vegetarian is simply: I like the taste of meat too much. The second and third most common reasons related to the high cost of meat substitutes and struggling for meal ideas.

These findings present climate and animal advocates with an interesting challenge. People are largely aware that there are good reasons to cut down their animal product consumption, but they are mostly not willing to bear the personal cost of doing so.

Decades of food behaviour research has shown us that price, taste and convenience are the three major factors driving food choices. For most people, ethics and environmental impact simply do not enter into it.

Experimental research has also shown that the act of eating meat can alter peoples views of the morality of eating animals. One study asked participants to rate their moral concern for cows. Before answering, participants were given either nuts or beef jerky to snack on.

The researchers found that eating beef jerky actually caused participants to care less about cows. People seem not to be choosing to eat meat because they think there are good reasons to do so they are choosing to think there are good reasons because they eat meat.

In this way, the default widespread (and, lets be honest, enjoyable) behaviour of meat eating can be a barrier to clear reasoning about our food systems. How can we be expected to discuss this honestly when we have such a strong interest in reaching the conclusion that eating meat is okay?

Fortunately, things are changing. The range, quality, and affordability of vegan options has exploded. My survey was conducted in September 2018, a few months before the tremendously successful release of Greggs vegan sausage roll.

Since then, we have seen an avalanche of high-quality affordable vegan options released in the British supermarkets, restaurants and even fast food outlets. These allow meat eaters to easily replace animal products one meal at a time. When Subway offers a version of its meatball marinara that is compatible with your views on ethics and the environment, why would you choose the one made from an animal if the alternative tastes the same?

The widespread availability of these options means that the growing number of vegans, vegetarians and flexitarians in the UK have more choice than ever. Not only will this entice more people to try vegan options, but it will make it far easier for aspiring vegetarians and vegans to stick to their diets.

With consumer choice comes producer competition, and here we will see the magic of the market. If you think those looking to cut down their meat consumption are spoilt for choice in 2020, just wait to see the effect of these food giants racing to make their vegan offerings better and cheaper as they compete for a rapidly growing customer segment.

We may be about to witness an explosion in research to perfect plant-based meat analogues. Meanwhile, the development of real animal meat grown from stem cells without the animals is gaining pace.

While these replacements get tastier, more nutritious and cheaper over the next ten years, meat from animals will largely stay the same. It is no wonder the animal farming industry is nervous. Demand for meat and dairy is falling drastically while the market for alternatives has skyrocketed.

In the US, two major dairy producers have filed for bankruptcy in recent months, while a recent report estimated that the meat and dairy industries will collapse in the next decade.

This leaves the average meat eater with a dilemma. Most agree with the reasons for being vegan but object to the price, taste, and convenience of the alternatives.

As these alternatives get cheaper, better and more widespread, meat eaters will have to ask themselves just how good the alternatives need to be before they decide to consume in line with their values. Being one of the last people to pay for needless animal slaughter because the alternative was only pretty good will not be a good look in the near future.

Read more:
What meat eaters really think about veganism new research - The Conversation UK

These are the best vegan Instagrams that you NEED to be following – The Tab

The guidance is needed tbh

Whether its for inspiration to try a plant-based diet this Veganuary, or just for some fresh ideas for you long-term vegans. These are the vegan Instagram accounts you should be following.

To start with the obvious, the Veganuary Instagram account has all you need. From recipes, to links to vegan blogs, to information about plant-based food on the high-street, to quotes from various vegan celebs, you will find it all here.

https://www.instagram.com/p/B6ljCjagLfR

Worried that a vegan diet might affect your time at the gym? Patrik Baboumian, star of the 2018 documentary The Game Changers, proves that you can be vegan and strong af. Patriks insta consists of workout videos, vegan memes and posts dealing with misconceptions about supplements.

Cute pet pics can also be found here just for some extra motivation.

This account run by co-founders Roxy Pope and Ben Pook has a range of yummy vegan recipes linked in their bio to try out, including smoked salmon using carrots and baked chocolate doughnuts.

This is the king of vegan Instagram accounts. Not only does it let you know all the delicious food you can eat across various supermarkets, but it separates some of the shops into individual saved stories too! It makes it super easy to look through a collection of vegan foods available at your supermarket of choice! Trust me, youll be surprised at what you can eat.

Sometimes the hardest bit about switching to veganism is avoiding beauty products that aren't obvious by-products of animals.

You dont think about your make-up or toiletries not being vegan but Veganbeautygirl, an account run by 12-year vegan Nicole Whittle, is a super helpful insight into vegan health and beauty. The account shows suitable products that range from deodorant to hair dye. For those interested in the environmental side of veganism, plastic free and biodegradable products are also tested by Nicole.

Run by Cardiff-based chef Gaz Oakley, this account is filled with incredible vegan recipes including chocolate milkshakes, a vegan brekkie and his iconic purple soup. Gaz even collaborated with Wagamamas in 2018 and create the dish avant-gardn (super delicious btw). This is definitely the account to visit when you're feeling like you've been eating the same chilli recipe for a month. We've all been there.

So sit back, take your B12, and let these vegan Instagram accounts do all the hard work for you.

Want to break stories like this? Join The Cardiff Tab now! Get in touch via DM @thetabcardiff or The Cardiff Tab on Facebook.

Is Fam Fish curry sauce vegan? We found out so you dont have to.

Here are the best places to eat and dine out as a vegan in Cardiff

Veganuary: Your guide to vegan beauty on a student budget

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These are the best vegan Instagrams that you NEED to be following - The Tab

12 surprising things that aren’t vegan – Inhabitat

Its hard to stick to a vegan lifestyle. It can be easy to be foiled by ingredients that just slip right by you, and these arent just in food. A surprising number of non-food items also contain animal-derived ingredients. Whats a wannabe vegan to do? Remember that drastically cutting down on animal consumption is good for the planet, even if you fall short of 100 percent. If you want to be as close to completely vegan as possible, heres a list of some surprising foods and other items that arent necessarily vegan.

The sugar industry uses bone char from slaughtered cattle to remove the color from sugar so it becomes a lovely, bright white. What about using brown sugar? Unfortunately, thats made of white sugar with molasses added to it. If you want to avoid bone char-processed sugar, buy organic, unrefined, beet or coconut sugar. You can also consult PETAs list of manufacturers that forego the bones.

Many condom manufacturers use the milk derivative casein for a smooth feel. If you can do without that texture, check out vegan-friendly brands.

Would you like some tendons with your fresh breath? Yep, those ubiquitous mints contain gelatin. Time for a Tic Tac instead, or opt for the Altoids labeled sugar-free smalls, which do not contain gelatin.

Related: 10 vegan myths, debunked

Charcoal can be made from plant or animal origins. But many of the black dyes used in tattooing are made with charcoal derived from animal bones. Other non-vegan ingredients in tattoo ink are glycerin (from animal fat), gelatin and shellac (made from crushed beetles). If vegan ink is important to you, consult this international list of vegan-friendly tattoo artists.

Now, its time for something really gross. Some companies use isinglass, or fish bladders, to clarify their apple juice.

Animal tendons and sinews find their way into a lot of food and non-food products. The outer layers of paintball capsules are usually made of gelatin.

Dryer sheets are designed to fight static electricity and make clothes soft and lint-resistant. But what keeps the sheets from drying out? In some cases, animal fat. Urban Vegan assembled a list of vegan alternatives, if you happen to use dryer sheets. Alternatively, you can also reduce your waste by opting to use wool dryer balls.

Artists and anybody who uses makeup might wonder, where did the hairs in my brush come from? They might be synthetic, or they might be from some poor pig, squirrel, sable or Siberian weasel. Artists, consult this list of cruelty-free brushes, and heres a list of vegan makeup brushes.

Related: The pros and cons of going vegan

In other art supply news, crayons contain stearic acid. This ingredient occurs naturally in plants and animals. But its often animal-derived, a slaughterhouse byproduct. Crayons are one of many products that contain stearic acid, including soaps, cosmetics, candles, lubricants, chewing gum and hairspray. If you prefer your crayons vegan, check out these triangular ones made by Melissa and Doug.

Newer vegans might not have realized this yet, but traditional Worcestershire sauce contains anchovies. Instead, make your own or buy this vegan, organic Worcestershire sauce from trusted brand, Annies.

If youre vegan, you probably already know that many regular cheeses arent even vegetarian, because they contain rennet, enzymes produced in bovine stomachs that help cheese curdle. But did you know many soy cheeses arent vegan? They often contain casein, which seems really weird, because why would you even want soy cheese if you werent vegan?

Vegans who live in or are visiting Britain arent thrilled to handle the 5 notes, which contain tallow, an animal fat derivative. It is used to make the bills anti-static and less slippery. British vegans and vegetarians have been protesting since the new notes were introduced in 2016. This month, a British employment judge ruled that the Equality Act should also apply to people who sincerely believe in ethical veganism. How an indirect discrimination case will affect the bank notes is still to be seen.

Could be beef tallow, could be chicken fat most plastic bags use some type of animal fat as slip agents to prevent bags from sticking together. One more good reason for banning plastic bags!

Images via Shutterstock

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12 surprising things that aren't vegan - Inhabitat

Lewis Hamilton became a vegan to ‘feel great’ and save animals – FOX 11 and FOX 41

Lewis Hamilton switched to a vegan diet to to save animals and feel great.

The Formula 1 champion who was named Person of the Year by animal rights organization PETA in 2018 has opened up about the positive impacts following a diet that is meat and dairy-free and without other animal-derived products has had on his performance, energy levels and the overall health of his gut.

He told the new issue of GQ Hype magazine: Ultimately, you want to feel great.

You want to have energy, to be consistent.

You dont want to have the big oscillations and highs and lows in your energy levels.

Veganism has eradicated that.

When I was 22, it was raw talent.

Youve got an abundance of energy, youre fit, there are no aches and pains

But Im always looking at how I can improve.

Can my eyesight be better? Can my reactions be improved? Are there new ways of testing my reactions?

The ergonomics in the car how can I make everything simpler?

Theres a multitude of things and Im always trying to raise the bar.

One of the things was my sleeping pattern and not feeling right in the stomach.

Your gut is your second brain.

The 35-year-old motor sportsman added that non-vegans are missing out.

He said: Were taught to drink milk and eat meat for protein and I started looking into other areas of research around all this.

The first thing was, whats happening to the animals? Secondly, the impact it can have on your body.

Thats a free advantage Im going to take.

If no one else wants it, well thats their loss.

Meanwhile, the British star quipped that he needs to pay Finnish racing driver Kimi Raikkonen, 40, to remain in F1 so hes not the oldest, but admitted that he feels as young as ever and fitter than ever, though he accepts that his fitness levels are bound to dwindle in years to come.

When the interviewer suggested hes an elder statesman, he said: No, I am. I need to start paying Kimi [Raikkonen] to stay so Im not the oldest.

Luckily, I think hes going to keep going.

I dont feel old at all.

I feel as young as ever.

I feel fit, fitter than ever.

Everything just works better now, with the experience I have.

I dont even think its harder to stay physically in shape, although Im sure that will inevitably tail off at some point.

See the full interview available online now via GQ HYPE http://www.gq-magazine.co.uk/cars/article/lewis-hamilton-interview-2020

FOX41 YakimaeFOX11 TriCities

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Lewis Hamilton became a vegan to 'feel great' and save animals - FOX 11 and FOX 41

Going vegan? Use this 12-week daily planner – Treehugger

It contains all the nutritional info, recipes, and moral support you'll need for a big dietary transition.

Have you ever wanted to go vegan, but didn't know where or how to start? Perhaps this new book could help you. Written by Michelle Neff, it is called Going Vegan: Your Daily Planner (Simon & Schuster, 2019), and it offers a detailed guide to making the transition from meat to meatless.

The book is divided into two parts. The first one delves into vegan health and nutrition, how to shop for vegan ingredients, and strategies for long-term success. The second one is the planner portion of the book, which has 12 weeks' worth of a daily diet plan, recipes, and a section for tracking personal results. A typical day looks like this:

I was impressed by the in-depth discussion of vegan health, presented at the beginning of the book. Neff addresses the problem of many wannabe vegans failing to get sufficient nutrients, and then giving up because they feel crummy.

"Some well-meaning people stop consuming milk, eggs, and dairy, but end up eating nothing but French fries, chips and salsa, or next to nothing at all, then wonder why they feel tired all the time... They blame it on veganism, with unfounded claims that they aren't getting enough protein, and then switch back to eating beef and cheese. Of course, it's not lack of protein that is getting these unhealthy vegans down; it's a complete lack of all nutrients."

It's clear that Going Vegan is designed to avoid this nutrient depletion. The meals are a well-balanced selection of grains, vegetables, and plant-based proteins, presented in recipes that sound absolutely delicious and easy to make. Neff doesn't shy away from discussing bloating, gas, cravings (and occasional failures), and criticism or judgement from non-vegans. The more open discussion about these factors, the more likely your long-term success.

Neff has good advice for figuring out where to start one's vegan journey. People are often told to give up meat first, followed by dairy, but this doesn't always make sense: "Dairy, and cheese in particular, is often the most difficult food to eliminate from your diet. This is a good argument for gradually eliminating it first rather than last, as it may take the longest to wean you off of it." She discusses the 'middle path' approach to veganism, which pushes meat to the side of the plate and makes it less of a central focus, more of a side dish.

The appeal of this 12-week meal planner is that it exposes new vegans to a broad range of healthy recipes right off the bat, preventing them from getting stuck in a rut that might be unhealthy, repetitive, and discouraging. If you follow it precisely, you'll be confident in the kitchen within three months and more likely to stick with veganism for life.

You can find the planner on Amazon or from other booksellers.

It contains all the nutritional info, recipes, and moral support you'll need for a big dietary transition.

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Going vegan? Use this 12-week daily planner - Treehugger

Rocker Brian May Would Have Tried Veganism Sooner – If He Realized How Delicious It Is – Plant Based News

Brian May is loving Veganuary (Photo:Bill Ingalls)

Brian May has revealed that he is loving the food he's been able to eat during Veganuary - and would have tried it sooner if he'd realized how delicious a plant-based diet can be.

The Queen guitarist, who is currently touring in Japan, is a longtime vegetarian and animal advocate, who decided to trial a plant-based diet because he was 'bothered' by campaigners for some animals while eating animal-derived food.

Posting on Instagram, the musician shared a picture of his breakfast, and wrote: "Vegan breakfast for a Big Day! You know, I think if I'd realized how easy Veganuary was going to be, I'd have done it earlier.

"I was under the impression I was going to be 'giving things up', but it seems to be an opportunity to eat more of the things I really love!"

The star revealed he'd be doing Veganuary 2020 last month, sharing the news with his 2.1 million Instagram followers, posting a picture of himself brandishing Veganuary's vegan guide.

He said: "Starting on the first of January I, this coming year I will be doing VEGANUARY. Which means I will eat only vegan food for that month.

"If any of you folks out there are hovering on the edge out there and want to join me too, I'd be delighted. We can mutually support each other! I figured this book is a good place to start.

"My reasons? 1) to lessen the suffering of animals. 2) To lessen the load on our groaning planet. 3) for my health. And...as an animal campaigner, it has been bothering me for a while that I still eat animal-derived food, that has caused indignity and pain to a non-human animal."

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Rocker Brian May Would Have Tried Veganism Sooner - If He Realized How Delicious It Is - Plant Based News