Global Covid-19 impact on Cellular Reprogramming Tools Market by Top Manufacturers, Demand and Growth Overview 2020 to 2025 – 3rd Watch News

Global Cellular Reprogramming Tools Market Research Report estimates the size of the market for 2020 and projects its growth by 2025. It provides a detailed qualitative and quantitative analysis of the Global Cellular Reprogramming Tools market. And collect useful data for this extensive, commercial study of the Global Cellular Reprogramming Tools market. The global Global Cellular Reprogramming Tools report is a basic hold of information, essentially for the business executives.

Development policies and plans are discussed as well as manufacturing processes and industry chain structure is analyzed. This report also states import/export, supply and consumption figures as well as manufacturing cost, global revenue and presents gross margin by regions like North America, Europe, Japan, China and other countries (India, Southeast Asia, Central & South America, Middle East & Africa etc.)

The Cellular Reprogramming Tools market report provides a detailed analysis of global market size, regional and country-level market size, segmentation market growth, market share, competitive Landscape, sales analysis, impact of domestic and global market players, value chain optimization, trade regulations, recent developments, opportunities analysis, strategic market growth analysis, product launches, area marketplace expanding, and technological innovations.

Final Cellular Reprogramming Tools Report will add the analysis of the impact of COVID-19 on this Market.

Cellular Reprogramming Tools Market competition by top manufacturers/Key player Profiled:Celgene, BIOTIME, Human Longevity, Advanced Cell Technology, Mesoblast, STEMCELL Technologies, Osiris Therapeutics, Cynata, Astellas Pharma, FUJIFILM Holdings, EVOTEC, Japan Tissue Engineering

>>> Get Free Sample PDF (including COVID19 Impact Analysis, full TOC, Tables and Figures) of Cellular Reprogramming Tools Market:

Market segment by Type, the product can be split into

General Type

Market segment by Application, split into

Drug DevelopmentRegenerative MedicineToxicity Test

The report offers in-depth assessment of the growth and other aspects of the Cellular Reprogramming Tools market in important countries (regions), including:

North America(United States, Canada and Mexico)

Europe (Germany, France, UK, Russia and Italy)

Asia-Pacific (China, Japan, Korea, India, Southeast Asia and Australia)

South America (Brazil, Argentina, Colombia)

Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)

In the context of China-US trade war and COVID-19 epidemic, it will have a big influence on this market. Cellular Reprogramming Tools Report by Material, Application, and Geography Global Forecast to 2023 is a professional and comprehensive research report on the worlds major regional market conditions, focusing on the main regions (North America, Europe and Asia-Pacific) and the main countries (United States, Germany, United Kingdom, Japan, South Korea and China).

In this report, the global Cellular Reprogramming Tools market is valued at USD XX million in 2020 and is projected to reach USD XX million by the end of 2024, growing at a CAGR of XX% during the period 2020 to 2024.

The report firstly introduced the Cellular Reprogramming Tools basics: definitions, classifications, applications and market overview; product specifications; manufacturing processes; cost structures, raw materials and so on. Then it analyzed the worlds main region market conditions, including the product price, profit, capacity, production, supply, demand and market growth rate and forecast etc. In the end, the report introduced new project SWOT analysis, investment feasibility analysis, and investment return analysis.

Market segmentation

Cellular Reprogramming Tools market is split by Type and by Application. For the period 2015-2025, the growth among segments provide accurate calculations and forecasts for sales by Type and by Application in terms of volume and value. This analysis can help you expand your business by targeting qualified niche markets.

For Customised Template PDF Report:https://www.reporthive.com/request_customization/2345556

The report also covers competitive developments, such as long-term contracts, new product launches and developments, and research & development activities being carried out various leading players such as company profiles, product picture and specification, capacity, production, price, cost, revenue and contact information in this market. It also provides information regarding various business and corporate strategies adopted by key players to strengthen their position in this market. In a word, the report provides major statistics on the state of the industry and is a valuable source of guidance and direction for companies and individuals interested in the market.

Major Points Covered in Table of Contents:

1 Cellular Reprogramming Tools Market Overview

2 Company Profiles

3 Market Competition, by Players

4 Market Size by Regions

5 North America Cellular Reprogramming Tools Revenue by Countries

6 Europe Cellular Reprogramming Tools Revenue by Countries

7 Asia-Pacific Cellular Reprogramming Tools Revenue by Countries

8 South America Cellular Reprogramming Tools Revenue by Countries

9 Middle East & Africa Revenue Cellular Reprogramming Tools by Countries

10 Market Size Segment by Type

11 Global Cellular Reprogramming Tools market Segment by Application

12 Global Cellular Reprogramming Tools Market Size Forecast (2021-2025)

13 Research Findings and Conclusion

14 Appendix

Customization Service of the Report:

Orian Research provides customization of reports as per your need. This report can be personalized to meet your requirements. Get in touch with our sales team, who will guarantee you to get a report that suits your necessities.

Main Aspects covered in the Report->>Overview of the Cellular Reprogramming Tools market including production, consumption, status & forecast and market growth->>2016-2020 historical data and 2021-2026 market forecast->>Geographical analysis including major countries->>Overview the product type market including development->>Overview the end-user market including development->>Impact of Coronavirus on the Industry

Key questions answered in the report-

Which are the high growth market segments in terms of type and countries?

What are the market forecasts and estimates for the period 2020-2025?

What are the major drivers, restraints, opportunities, and challenges in the Cellular Reprogramming Tools Market equipment market?

What are the different strategies adopted by the major players in the Cellular Reprogramming Tools Market equipment market?

What are the geographical trends and high growth countries?

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Global Covid-19 impact on Cellular Reprogramming Tools Market by Top Manufacturers, Demand and Growth Overview 2020 to 2025 - 3rd Watch News

Bats’ Ability to Combat Viruses and Control Inflammation Provides Insights in Fighting COVID-19 – Nature World News

Jul 17, 2020 09:10 AM EDT

The longevity of bats and their ability to combat viruses help them control inflammation, giving scientists insights on possible tools for combating COVID-19.

Bats have been implicated in many new and even older pathogens that afflict humanity. These include rabies, Ebola, and SARS-nCoV-2, which causes COVID-19. Bats have been observed to have remarkable resistance to these viruses. In addition, they have longer lifespans compared to similarly-sized mammals.

Researchers published an article in Cell Metabolism outlining bats' unique abilities and mechanisms and how they can help develop treatments for human diseases. The authors are biology professors Andrei Seluanov and Vera Gorbunova from the University of Rochester and the National University of Singapore Centre for Healthy Aging director Brian Kennedy.

The COVID-19 causative agent, SARS-nCoV-2, along with a host of other viruses, are thought to have come from bats, who serve as carriers; the bats themselves do not seem to develop disease from it. In addition, a lot of bat species have 30- to 40-year lifespans, which is unusual for their small size, since smaller animals tend to live shorter lives. Gorbunova says that the resistance of bats to infections may be connected to their long life. This could give clues on formulating human treatment.

The researchers' studies also showed inflammation's role in age-related illnesses and aging. Such diseases include Alzheimer's, cardiovascular disease, and cancer. Viruses such as COVID-19 can also cause inflammation. Gorbunova says that the inflammation may be the factor that kills COVID-19 patients.

Gorbunova says that the immune system uses inflammation and fever to fight viral and bacterial infections, but these responses can also overreact and pose a danger to the body itself.

Unlike us, bats have mechanisms that inhibit viral replication and dampen immune responses to viral infections. This causes an optimal bodily reaction, wherein the viruses are controlled with little inflammatory response.

The study authors say that various factors could be contributing to the evolution of bat disease resistance and longevity. The flight could be one factor since it lets bats adapt to rapid body temperature rise, molecular damage, and sudden metabolic surges. Such adaptations are useful in fighting disease.

The environment could be another factor. Dense and large bat colonies are the perfect venue for disease transmission. This constant exposure to viruses triggers bats' immune systems into always being active in a perpetual war with pathogens. Their immune system is always busy evolving mechanisms to combat new pathogens that regularly come in contact with them and their colonies. Gorbunova says that the strongest adaptive or evolutionary driver of disease resistance is a constant war against pathogenic organisms. Dealing with so many viruses, she says, could be developing better immunity and longer lifespans.

Such evolution develops over thousands to millions of years, and will not work for human adaptation to COVID-19. Only recently have humans congregated in congested cities or developed frequent world travel. Humans simply haven't evolved the complex mechanisms of bats. Gorbunova says our bodies may respond to such pathogens with more inflammation.

The study authors also think that aging may exacerbate the harmful effects of COVID-19 in humans. Gorbunova says the pathogenesis of the disease is different in the elderly.

The study authors think that the study of the bat's immune system will provide new therapies against humans aging and diseases. One possible research focus is the inhibition in humans of genes that cause inflammation; these genes have been eliminated in bats.

2018 NatureWorldNews.com All rights reserved. Do not reproduce without permission.

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Bats' Ability to Combat Viruses and Control Inflammation Provides Insights in Fighting COVID-19 - Nature World News

Can India Lead The ‘vegan Economy’ Against Future Pandemics? – Forbes India

Image: Shutterstock

The WHO estimates that 75 percent of new diseases discovered in the last decade have originated in animals (zoonosis). This is primarily because more than 90 percent of the meat we consume is sourced from a vast industry of factory farms that house farm animals in unhygienic conditions. This presents a perfect breeding ground for viruses. To prevent future virus outbreaks, a part of the solution may lie in moving towards a more plant-based diet. In this regard, India might be sitting on a gold mine of opportunity.

The vegan movement advocates for a shift to a 100 percent plant-based diet with the objective of ending animal cruelty. While India is still a milk-loving nation, it is well placed to anchor the movement away from meat consumption. The hostility against the slaughter of animals, immense regulation of abattoirs, and prevalence for meat and egg-free apartments and localities are all proof of Indias natural inclination towards this cause.

The WHO estimates that the herbal and ayurvedic market will reach $5 trillion by 2050 from the existing $62 billion, with China and India having 13% and 2.5% shares, respectively. In 2019, Barclays Plc estimated the meat substitute industry would grow to $140 billion in the next decade; this is likely to be higher owing to the present crisis. The time couldnt have been riper for India to capitalise on this huge opportunity to promote its vegetarian philosophy, products and beliefs.

India should leverage its natural strengths by strategic actions

The image that India is one of the only major vegetarian-friendly economies in the world can work to its advantage in the global marketplace if we work hard. India has mastered the vegetarian supply chain for snacks and other packaged food items, which are not the case in animal oil-rich global packaged-snack supply chains.

In recent years, the Indian state of Kerala has immensely profited from the export of jackfruit for the global vegan market as a substitute for meat. The otherwise nuisance crop in the state is now being exported to the tune of more than 500 tonnes yearly.

The global market already has a huge demand for Indian organic supplements and medicines. Organic products include original harvested honey, juice of fruits and vegetables, herbs, etc. Ayurvedic products alone are exported from India at close to $500 million yearly. As the popularity of Yoga, Spiritualism, Ayurveda, etc. has spread like wildfire in the West, India has claimed the spot as the original source of herbal and organic goods for a healthy life. Having strong demand, these products are already sold at great prices abroad.

The 'Vegan India' campaign, with respect to food products, can be constructed as a symbol of the global fight against Covid-19. The brand construction promoting cleanliness, nutrition and safety should be complemented by on-ground institutional mechanisms. Though vegan conferences are not a novel idea, India should strive to create a Kumbh Mela of sorts for vegans to flock to the Indian shores to indulge in Indian vegan delights.

It is interesting to note, many vegans abroad choose Indian vegetarian restaurants over others as they guarantee a cuisine closer to their dietary preferences. In this regard, India has the potential to export its diverse culinary arts in addition to limited Indian cuisines available abroad and promote them in the line of plant-based, healthy, tasty and nutritious food for good health.

Not too long ago, Indian products such as ghee were rendered unhealthy for the body by western media. However, these views have presently been overturned upon latest research and, along with ghee; other products such as cold-pressed oils of mustard and coconut have also gained traction.

With Indias image as a vegetarian powerhouse and the variety of climatic zones and soil conditions it has, there is ample scope in gaining a foothold in the global vegan economy. India has 45,000 diverse plant species spread over 16 different agro-climatic zones. Its rich history of Ayurveda and herbal medicine is recorded since Vedic times.

India, however, despite its potential, unfortunately focuses more on the export of crude substance or primary extracts. Alternatively, the market for branded finished products should be tapped. Imagine a scenario where Indian brands like Haldiram's filling the aisles of global supermarkets and Indian fast-food restaurants delivering a healthy alternative to the ubiquitous western fast-food chains. The time to act is now as global crises have a history of creating new global champions.

The government has already given incentives to drug manufacturers, entrepreneurs, AYUSH institutions etc. for registration of their products for exports to targeted countries. A further push with the help of Agricultural and Processed Food Products Export Development Authority (APEDA), to identify the strengths of Indian agricultural products with respect to vegan requirements, is the need of the hour.

For India to be able to tap into the global vegan market, it has to improve (1) efficiency in agricultural practices and knowledge, (2) R&D of food supply-chain, (3) quality of supply chains linking the producers with the global demands and regulations, and (4) standards and labelling of vegan products.

India has a potential for moral leadership in a number of areas; anchoring global vegetarianism/veganism is one of them. Its up to the foresight of decision-makers and entrepreneurs to find these opportunities and take advantage of them, and push Indias image as a global vegan economic powerhouse.

Ankush Das is a Policy Analyst at ETTMA and Kowthamraj VS is a Young Professional at NITI Aayog

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Can India Lead The 'vegan Economy' Against Future Pandemics? - Forbes India

Princess Anne disagrees with Prince Charless views on veganism: You cant have a world without livestock – The Independent

The Princess Royal has shared her views on topics such as genetically modified (GM) crops, climate change and veganism, which are in stark contrast to those of her brother, the Prince of Wales.

In a new interview with Australian Women's Weekly, Princess Anne discussed her thoughts on veganism, saying that "you cant have a world without livestock".

"They are a necessary and very constructive part of our expectation to feed ourselves," she said.

Sharing the full story, not just the headlines

Perhaps my biggest irritation is single-issue groups...We need livestock as part of the genuine mix that keeps land healthy.

While Prince Charles has never explicitly spoken about following a vegan diet, he has expressed concerns over the environmental impacts of animal agriculture.

In 2011, he attended a conference in Washington where he pleaded with people to eat less meat: "For every pound of beef produced in the industrial system, it takes two thousand gallons of water," he said.

"That is a lot of water and there is plenty of evidence that the Earth cannot keep up with the demand."

Anne also opened up about her thoughts on the use of genetically modified crops, stating that they have been enormous advantage in specific environments.

She also revealed that she and Charles had occasional but rather short conversations about farming, despite the pair owning land near to each other in Gloucestershire.

It has been an enormous advantage in many parts of the world to use GM wisely for very specific environments, Anne said.

It makes it much more likely to be able to grow what you need.

(Getty)

I have to remind people that rapeseed oil was only made non-toxic to humans by the Canadians after the Second World War by genetically modifying the plant. It's (ironically) quite popular with all those people who don't like GM.

Charles, who is a passionate organic farmer, has previously spoken out against GM and is also royal patron of the Soil Association, which has campaigned against GM crops and ingredients in human and animal food.

The royal recently urged people to think about more sustainable ways of consuming and producing food and praised the UKs dig for victory spirit, referring to those who have started growing their own produce.

Anne's views on climate change also contrast to those of her older brother, with the royal saying she would not go down the climate change route when looking for causes of Australia's bushfires.

A two-year-old Prince Harry holds the hand of his mother, Princess Diana, at Aberdeen Airport. (1986)

Photo by Carraro/REX

Aged two years old, Prince William is photographed outside the Lindo Wing at St Mary's Hospital, London, following the birth of his younger brother Prince Harry. (1984)

Photo by Mauro Carraro/REX

Prince George arrives for his first day of school at Thomas's London Day School in Battersea. (2017)

AFP/Getty Images

Princess Charlotte waves on the steps of St George's Chapel, Windsor, as she arrives at the wedding of Princess Eugenie and Jack Brooksbank. (2018)

Photo by Steve Parsons - WPA Pool/Getty Images

A newborn Prince Louis is pictured outside the Lindo Wing at St Mary's Hospital, London. (23 April 2018)

Photo by Chris Jackson/Getty Images

A portrait of Queen Elizabeth II, then Princess Elizabeth, aged three or four years old. (circa 1929-1930)

Photo by Universal History Archive/REX

Princess Margaret is pictured alongside her elder sister Princess Elizabeth, later Queen Elizabeth II. Princess Elizabeth carries a purse embroidered with the letter "E" and a crown. (circa 1933)

Photo by Richard Gardner/REX

Prince Philip is pictured in Corfu, Greece, at the age of 14 months. (1922)

Photo by REX

Prince Charles waves after his parents Queen Elizabeth II and the Duke of Edinburgh as they drive a procession of welcome following their return from Canada (1951)

AFP/Getty Images

A six-year-old Prince Andrew looks out from a window at Buckingham Palace. (1966)

Photo by McCabe/Express/Hulton Archive/Getty Images

An official portrait is taken of Princess Anne, a day before her fourth birthday. (1954)

STF/AFP/Getty Images

A four-year-old Prince Edward turns in his seat as he attends the annual Royal Windsor Horse Show. (1968)

Photo by P. Felix/Daily Express/Getty Images

A two-year-old Princess Beatrice sits underneath a presentation table at the Royal Berkshire Polo Club, holding a fluffy toy. (1991)

Bill Cross/Daily Mail/REX

A young Princess Eugenie holds her mother, the Duchess of York's hand as she leaves Upton House School Windsor on her elder sister's first day of school. (1991)

Photo by Mike Forster/ANL/REX

A four-year-old Camilla Parker Bowles, later the Duchess of Cornwall, is pictured with her two-year-old sister Annabel. (1952)

Photo by Ann Cleaver/REX

Zara Phillips, daughter of Princess Anne, attends the Royal Windsor Horse Show aged two. Zara went on to become an equestrian and Olympian. (1983)

Photo by Paul Massey/Mail On Sunday/REX

A two-year-old Prince Harry holds the hand of his mother, Princess Diana, at Aberdeen Airport. (1986)

Photo by Carraro/REX

Aged two years old, Prince William is photographed outside the Lindo Wing at St Mary's Hospital, London, following the birth of his younger brother Prince Harry. (1984)

Photo by Mauro Carraro/REX

Prince George arrives for his first day of school at Thomas's London Day School in Battersea. (2017)

AFP/Getty Images

Princess Charlotte waves on the steps of St George's Chapel, Windsor, as she arrives at the wedding of Princess Eugenie and Jack Brooksbank. (2018)

Photo by Steve Parsons - WPA Pool/Getty Images

A newborn Prince Louis is pictured outside the Lindo Wing at St Mary's Hospital, London. (23 April 2018)

Photo by Chris Jackson/Getty Images

A portrait of Queen Elizabeth II, then Princess Elizabeth, aged three or four years old. (circa 1929-1930)

Photo by Universal History Archive/REX

Princess Margaret is pictured alongside her elder sister Princess Elizabeth, later Queen Elizabeth II. Princess Elizabeth carries a purse embroidered with the letter "E" and a crown. (circa 1933)

Photo by Richard Gardner/REX

Prince Philip is pictured in Corfu, Greece, at the age of 14 months. (1922)

Photo by REX

Prince Charles waves after his parents Queen Elizabeth II and the Duke of Edinburgh as they drive a procession of welcome following their return from Canada (1951)

AFP/Getty Images

A six-year-old Prince Andrew looks out from a window at Buckingham Palace. (1966)

Photo by McCabe/Express/Hulton Archive/Getty Images

An official portrait is taken of Princess Anne, a day before her fourth birthday. (1954)

STF/AFP/Getty Images

A four-year-old Prince Edward turns in his seat as he attends the annual Royal Windsor Horse Show. (1968)

Photo by P. Felix/Daily Express/Getty Images

A two-year-old Princess Beatrice sits underneath a presentation table at the Royal Berkshire Polo Club, holding a fluffy toy. (1991)

Bill Cross/Daily Mail/REX

A young Princess Eugenie holds her mother, the Duchess of York's hand as she leaves Upton House School Windsor on her elder sister's first day of school. (1991)

Photo by Mike Forster/ANL/REX

A four-year-old Camilla Parker Bowles, later the Duchess of Cornwall, is pictured with her two-year-old sister Annabel. (1952)

Photo by Ann Cleaver/REX

Zara Phillips, daughter of Princess Anne, attends the Royal Windsor Horse Show aged two. Zara went on to become an equestrian and Olympian. (1983)

Photo by Paul Massey/Mail On Sunday/REX

The Queen and other senior royals sent messages of condolence to those affected by the fires after at least 20 people died and more than 1,400 homes were destroyed over the Australian summer.

I don't even go down the climate change route, Anne told the magazine.

I think the way people manage ground is part of the discussion...climate changes all the time. It has done so throughout the globe's history, so there's nothing new under the sun.

She continued: Somehow, we've got to learn that our kind of life is changing. We've got to remember to respect what's out there and how to live with it.

In contrast, Charles recently said there was a golden opportunity to create something good for the environment from the Covid-19 crisis during an appearance at the launch of the Great Reset project.

Its unprecedented shockwaves may well make people more receptive to big visions of change, and global crises like pandemics and climate change know no borders and highlight just how interdependent we are as one people sharing one planet, he said.

Charles is the Queens eldest child and was born on 14 November 1948 followed by his sister, Anne, on 15 August 1950.

After her first two children, Queen Elizabeth waited more than a decade before welcoming her third child, Prince Andrew in 1960 and youngest, Prince Edward, in 1964.

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Princess Anne disagrees with Prince Charless views on veganism: You cant have a world without livestock - The Independent

Alice Veglio: The New Face Of The Innovation In Healthy Lifestyle And Women Empowement – Forbes India

In the hectic everyday life, more and more women feel the need to access the world of fitness and health with the immediacy and speed of a click on their smartphone. It is precisely from this need that Alice Veglio, international model, influencer and personal trainer with Coni certification started her business. Graduated in Holistic Sciences at Leonardo Da Vinci University of Rome in 2017, in her curriculum Alice boasts work apprenticeships at the Dubai Carbon Center of Excellence first as a project assistant and then as a journalist for The Sustainability magazine and as a junior project manager in 2018 at the Wgeo delle United Nations. In 2016 Alice was also selected among the 100 best students worldwide to participate in the Zero Hackathon, the first competition of ideas and entrepreneurship for young talents that was held at the FAO in Rome. In 2019 Alice Veglio also reached 2nd place at Miss Multiverse World Finals in Punta Cana: the first beauty, intelligence, fitness and entrepreneurship competition in the world for the 21st century women.

Graduated in economics and business management, she is one of the few Italian personal trainers to be a certified student of the American College of Sports Medicine, the largest institution in the world for sports medicine operators and an international reference point for all professionals in the sector. In January 2019 Alice takes advantage of her double university education to carry out an innovative project on the market: one of the first online fitness programs entirely in Italian to promote health and empowerment throughout the female world. I wanted to bring a new digital fitness concept. What separated women from achieving their physical and health goals was time. My program really offers the comfort and simplicity of being able to always have your personal trainer with you without the need to travel. Thus was born the fitness portal http://www.fitness.aliceveglio.com which in less than a year has reached over 10.000 female members who are active regularly. Alices company WANDERLUST FZE is based in the UAE, where she is well-known as model, influencer and trainer and has successfully reached in a few months revenues over 6 figures from her online business.

In addition to this Alice innovates the way of teaching fitness on YouTube with live masterclasses that promote topics related to the health and personal growth of women and their fulfillment. The channel has reached 32.000 subscribers in a few months and is regularly followed by thousands of people with videos reaching over 200k views. I like to call it holistic fitness: a new vision of wellness that puts the mental well-being and health of each person first. I am fighting to share true information in an era when between all this aggressive marketing, false information and technicalities it seems impossible to discover the way to true inner well-being ". Alice shares her mission daily also on Instagram where she counts over 150 thousand followers. At the moment she is dedicated to sharing content on social networks together with a team of 10 people to further expand her online fitness platform which represents an absolute novelty in the market of Italy and the UAE and represents a great innovation in the fitness industry. Bright and Fit has also released the official app on the Google and Apple stores, the first 100% Italian fitness app. It was designed to make a healthy lifestyle more accessible with all the information just one click away. I want to make it easier for all women to stay fit by utilizing the best certified protocols and the infinite potential of the digital world ".

Alice is spreading her influence worldwide and in all ME sharing the highest level of innovation in fitness and wellness field and her approach made by the mix of motivation, right information and her focus on women empowered has really made Bright & Fit one of the most successful startups in the Middle East this year.

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Alice Veglio: The New Face Of The Innovation In Healthy Lifestyle And Women Empowement - Forbes India

Virtual VeloSano: Local mom with stage 4 metastatic breast cancer defying odds and cycling on – WKYC.com

Virtual VeloSano participant knows firsthand the importance of funding research, and finding a cure

CLEVELAND Since beginning in 2014, the VeloSano Bike to Cure has raised more than $21 million for research, trials, and cancer treatment, here at the Cleveland Clinic. Now, the pandemic may have forced VeloSano to go virtual in 2020, but make no mistake, its not stopping the army of participants committed to the cause.

Among them is Kate Watson, a busy mom, leading an active healthy lifestyle with two beautiful little girls and a loving husband. But in 2016 she got news no woman wants to hear.

I was diagnosed with metastatic or stage 4 breast cancer. I was 35 years old with no family history. Two young kids at home. It came out of left field, Kate said as we talked to her via Zoom.

By the time she was diagnosed, the disease had already metastasized, spreading to several other places on her body including lymph nodes in her chest, her spine, pelvis, and the bone in one leg. Doctors determined Kate was not a candidate for surgery. Rather, they took the approach of attacking the cancer with targeted chemotherapy.

The average life span for someone diagnosed with stage 4 metastatic breast cancer is just three years. Kates treatment results have been amazing.

Currently there is no evidence of active disease, which is not the norm for somebody with this diagnosis. This week will actually be my 75th chemo infusion. I will be in treatment for the rest of my life because there is no cure for metastatic breast cancer, Kate shared.

When Kate beat the average life expectancy, she decided it was time to give back to the people she really credits with helping her.

Last year was our first ride with VeloSano. My husband and I both signed up for the 10-mile and it was so much fun and just so uplifting. It just felt so good giving back to the people who gave it to me, she shared.

Crossing the finish line of last years VeloSano is something Kate compares to finishing chemotherapy. Shes taking back some of the power cancer can have over your life. Her doctors and cheer team at the Cleveland Clinic by her side, throughout this journey.

I just looked at them and saw their optimism and their determination and their hope. That I could lead a full life. And thats why today, I want to support them because I want anybody to know thats facing a cancer diagnosis, that there is hope, she said.

On Saturday, Kate will be joined by her family, friends, and neighbors in Rocky River. Each lap around their street is a mile. The Beaconsfield Bikers will be doing 20 laps to make up a 10-mile ride. And its important to point out that you dont have to bike this year. The Virtual VeloSano allows folks to participate in any number of ways including walking, running, hiking, riding a scooter, however you like.

There is still time to get involved with the event. You can sign up here.

And check out Kate's team: The Beaconsfield Bikers.

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Virtual VeloSano: Local mom with stage 4 metastatic breast cancer defying odds and cycling on - WKYC.com

How To Instill A Healthy Attitude About Exercise In Your Kids – HuffPost

When it comes to a childs relationship with physical activity, its clear that parents play a major role.

Parents are typically the earliest influence in the childs development of attitudes and values, including those related to food, body image and exercise, said Claire Mysko, CEO of the National Eating Disorders Association.

Research on this topic has found that children of parents who are overly concerned about their weight are at increased risk for modeling their unhealthy attitudes and behaviors, like compulsive exercise, she added. On the flip-side, research indicates that children of parents who have a healthy relationship with food, exercise and body image are more likely to have positive self-esteem, improved school and social functioning, and a reduced risk for eating disorders.

Its natural to want to encourage your child to be active to promote their physical and mental health, but parents should be mindful of the way they go about this. Sometimes, focusing too much on exercise can foster negative associations in kids.

To help promote positive relationships with fitness, HuffPost spoke to Mysko and other experts to identify everyday ways parents can instill a healthy attitude about exercise in their kids.

Separate exercise from physical appearance.

One major way to foster a healthy attitude toward exercise is to separate it from how a person looks.

In our thin-obsessed culture, its too easy for children to come to believe that the purpose of exercise is to obtain a thin body or to lose weight or to achieve a certain physical appearance, said Rebecca Puhl, a professor in the department of human development and family sciences and deputy director for the Rudd Center for Food Policy & Obesity at the University of Connecticut. These messages are damaging to youth, so parents need to be mindful of those broader societal messages that children see and hear, and to instead focus on engaging in physical activity for the purpose of health and well-being.

As with other issues, parents can offer counter-messaging to combat the harmful notions about fitness and body image that kids may absorb from advertising, pop culture or even their peers. Caregivers should avoid words, behaviors and actions that tie exercise to the pursuit of weight loss.

Parents can encourage physical activity as part of a healthy lifestyle rather than a means to achieving a certain weight or body size, Mysko said. By shifting the focus away from appearance, we can frame exercise in the context of joyful movement: walking the dog, play dates at the park, impromptu dance parties, and more.

seksan Mongkhonkhamsao via Getty Images

Talk about physical activity in a positive way.

Parents should examine their own attitudes toward exercise and try to work through any harmful tendencies. They should also be mindful of their communication about physical activity in front of their children.

Small comments can have a lasting impact on a child as they develop beliefs about their body image and satisfaction or dissatisfaction, said Lindsey Giller, a clinical psychologist in the Mood Disorders Center at the Child Mind Institute. If a parent says, Ugh, in order to eat that dessert, Im going to need to spend hours at the gym or I hate exercising, its such a drag, kids pick up on that and internalize it.

If parents make it clear that they see exercise as a chore or negative experience, that view may rub off on their children. Instead, they can make an effort to talk about movement in a positive way and highlight how it makes them feel good physically and mentally.

Parents could also speak about their enjoyment of a challenging physical activity, said Nailah Coleman, a sports medicine pediatrician and American College of Sports Medicine fellow. When finishing a nice run, game of catch or swim in the pool, a parent could say, Wow! That was fun! Even though running that mile was hard/even though it is difficult to throw very far right now/even though swimming that last lap made me tired, I am proud that I finished it and did my best. How do you feel about our activity?

Model an active lifestyle.

Our children are much more likely to follow our behavior than to follow our instructions, Coleman noted, adding that parents can serve as models for active living. If we do it regularly and with enjoyment, they will consider it part of a healthy life and be more likely to do it, too, especially if we include them in our activities.

Parents should try to encourage and integrate movement in everyday life. Those who are able-bodied may consider participating in adult sports leagues, biking to work, going for regular runs and taking dance classes.

Hold family yoga classes, especially with young children, as its an excellent way to do healthy exercise which also promotes more general emotional wellbeing, suggested psychotherapist Noel McDermott. Active play with younger kids in the local park is great fun. If you have the courage to learn to climb trees in your local park, children love this form of activity, which is also great exercise. Family days out rambling is also a great, fun activity which provides super bonding time, exercise and all the well-being benefits of being in nature.

fizkes via Getty Images

Find out what type of movement your kids enjoy.

Another way parents can help foster a healthy attitude toward exercise is by asking their children what type of movement makes them feel good inside and out, Mysko said.

If kids dont have an answer, you can suggest some ideas and see which they might be willing to try. It doesnt have to be a formal sports team, but could simply be riding their bike, dancing to their favorite music or at-home yoga. Dont show displeasure if they arent interested in your favorite form of exercise, and instead be supportive of their participation in whichever activities they enjoy.

Together, you might consider creating an activity list for the upcoming week or month, Giller suggested. Kids are more likely to buy into things if they feel an element of control in choosing the way to participate.

You can give kids control by involving them in decision-making about group activities, like choosing the route for your family walk. Once youve determined which forms of physical activity they enjoy, show your support by signing them up for programs, providing transportation, buying equipment and even engaging in the exercise with them. Identify times of day that are best for these activities and make them a regular part of the family routine.

Make movement fun for the whole family whether its going for a walk or bicycle ride as a family, building an obstacle course and timing how long it takes for the kids to complete it, or blasting music to have a dance party to start the day, Giller said. Parents can plan activities or trips that promote new ways to exercise, such as hiking, kayaking, rock climbing. Allowing kids to invite friends along also helps to make exercise more social and fun.

Dont make it about competitive sports.

Avoid becoming too focused on competitive sports as the only or major form of exercise, McDermott advised. There is an important role for those activities, but it can become problematic. The focus should be on health and wellbeing, not success or achievement.

He noted that interest in competitive sports often evolves naturally from general enjoyment of physical activity, so its best to let it happen that way, rather than push competition on kids. Seeing exercise strictly as a way to win is not a particularly healthy attitude.

Its better to value exercise in a way that emphasizes health and wellbeing, not simply excellence, McDermott explained. Exercise needs to be seen in the context of whole person development and not simply be an end in itself.

Parents should focus on skill-based accomplishments, rather than wins or numbers like calories burned and pounds lost.

Look for ways to praise the childs effort in developing the n
ew skill, whether that is doing jump rope, riding a bicycle, or learning to play a sport, Giller suggested. When a child notices improvement in a new activity, they are more likely to stick with it.

Sladic via Getty Images

Never use exercise in the context of shame or punishment.

Avoid body-shaming as a way to motivate kids to get moving, Giller advised. Statements such as look at how much weight youve gained from sitting around on your computer these past three months or when was the last time you moved? are likely to induce feelings of shame and insecurity about ones body and may backfire in terms of a childs willingness to engage in any physical activity.

When kids are engaging in physical activity, dont show judgment or suggest theyre doing something wrong (unless they are at risk for harm). This makes the activity less enjoyable.

Parents should not force children to engage in vigorous physical activity or specific activity programs against their will, noted Russell R. Pate, a former ACSM fellow and director of the Childrens Physical Activity Research Group at the University of South Carolina. Parents should not criticize their children (particularly in front of siblings and peers) if they are not successful with a particular physical activity. Rather, parents should help children find forms of activity they enjoy and feel successful with, and then reinforce participation in those activities.

Using exercise as a form of punishment is also a big no-no. Rather than relieving stress, it makes movement inherently more stressful and negative. Physical activity should not be something kids dread; it should be something they feel self-motivated to pursue.

Pay attention to your childs behavior.

Even if you follow all the expert advice, its still important to pay attention to your childs relationship with exercise. Laura Collins Lyster-Mensh, executive director of FEAST (Families Empowered And Supporting Treatment for Eating Disorders), said that some children learn harmful attitudes, but others may simply have a more innate inclination.

If you see a young person starting to have strong thoughts and behaviors that center on eating or exercise, have your antenna up, she cautioned. There may be a mental illness coming into play, and that needs to be treated differently.

One thing to look out for is if your child is engaging in a physical activity not because they want to, but because they feel like they have to, and if theyre giving themselves breaks to rest when theyre tired. Excessive or compulsive exercise is often a symptom of eating disorders.

If you suspect that your young person is experiencing mental illness that involves eating, body image, or exercise, then its a really good idea to check in with a mental health professional who is trained in eating disorders, Lyster-Mensh explained. Eating disorder professionals are very good at figuring out the difference between an impulse that is true to the person and one that is being driven by mental illness. Early intervention with eating disorders is really important. It can save a life.

This story is part of Dont Sweat It, a HuffPost Life series on improving your relationship with fitness. Were giving you a guide on the latest thinking on exercise and why weve been conditioned to hate it in the past. Mental health and body-positive fitness experts will offer guidance and show you how to find a routine that works for you. Find all of our coverage here.

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How To Instill A Healthy Attitude About Exercise In Your Kids - HuffPost

Food Circle Supermarket: ‘We want to be one of the largest food surplus retailers in Europe’ – FoodNavigator.com

Food Circle was launched in 2018 on a shoe-string. Co-founders Paul Simpson and James Barthorpe met while working for one of the UKs largest surplus food re-distributors.

Simpson was inspired by this model. After seeing the positive impact that reducing food waste could have on the environment [I] wanted to create a business that stopped surplus food from going to waste whilst also helping others live a healthy lifestyle, he told FoodNavigator.

Simpson pitched the idea to Barthorpe and asked him if he was up for the ride. Fortunately, James instantly loved the idea to create an online store where customers could purchase surplus food that is in-date and healthy too.

The new entrepreneurs 'saved up money, left their jobs and launched in January 2018 on a shoe string.

Since then, Food Circle Supermarket has sold over 500,000 surplus food and drink items through its online store.

Food Circle Supermarket has direct partnerships with all of the brands it works with. The company works to forge close working relationships that sees brands alert the company to surplus stock, and both parties come to an agreement.

The stock is then delivered to Food Circle Supermarkets depot in Sheffield. Food Circle Supermarket is a fully centralised model. All stock comes to the depot in Sheffield, where it is stored, sold via Food Circle Supermarkets own e-commerce store, and then picked and packed before being shipped out to customers directly across the UK and ROI via the couriers.

This system means the company can be confident in the quality of the products it supplies to customers. This direct from supplier model guarantees quality, as well as the fact Food Circle Supermarket always asks its brands to sign food safety forms (and provide relevant certification) to guarantee food safety, Simpson said.

Importantly, the model is a win-win-win for Food Circle Supermarkets customers, suppliers and the environment, he continued.

Food Circle Supermarket works to solve key problems for consumers, suppliers and the environment.

For the consumer, Food Circle Supermarket provides products that are discounted from the normal retail price, enabling them to choose healthier options and complement their healthy lifestyles for less, whilst saving surplus food from potentially going to waste.

For the supplier, Food Circle Supermarket provides a commercial return for surplus stock, and a secure and transparent route that will protect their brand integrity.

And last, but definitely not least, for the environment Food Circle Supermarket helps to reduce surplus food from going to waste and therefore minimises the negative impact that this has on the environment.

Food Circle Supermarket currently acts as a retailer for healthy snacks, protein products and drinks, This can include high protein, gluten free, organic, vegan and vegetarian, as well as healthy alternatives to mainstream products.

When Simpson and Barthorpe were drawing up the business model, they knew that they needed to focus on specific categories otherwise the approach would be too scatter-gun.

The companys focus was initially on gluten-free products, which was witnessing a jump in consumer interest at the time.

As time moved on, the business moved into the sports nutrition sector following on from customer feedback It was an organic shift for the business and the focus then turned to this category.

Simpson revealed Full Circle Supermarket absolutely expects to continue to evolve its offering. Food Circle Supermarket is constantly expanding its offering both product and brand wise and is already doing more gluten free (again) and vegan products, as well as new things such as coconut waters and porridge pots.

The business plan is to expand much broader as the growth continues, however this takes time and is best not to be rushed. The long-term goal is to provide a one-stop shop for all surplus food, he told us.

A focus on health is important to the companys mission. The business is proud to help people achieve their healthy lifestyle goals at an affordable price whilst also benefiting the environment too, Simpson explained.

Its consumers, Simspon elaborated, tend to be ordinary people with busy and active lifestyles.

With most of the products available being perfect for on-the-go healthy snacking, such as bars and shakes, the majority of Food Circle Supermarkets products cater for this category.

Demand has spiked during the COVID-19 lockdown, with sales up 68% from 2019 levels in the January-to-June period alone as shoppers increasingly look to e-commerce.

Food Circle Supermarket has had an extremely busy year following on from business growth being accelerated by COVID-19. Food Circle Supermarkets sales had literally doubled in size overnight and have shown no signs of slowing down since, Simpson reflected.

Due to this growth, Food Circle Supermarket has now outgrown its current warehouse after taking up all of the available units at the business centre it operates from. The next step for the business is to move into a new build 6,500 sq/ft premises in August. This move will be in conjunction with a recruitment drive on both an operational and office basis, the co-founder revealed.

Food Circle Supermarkets longer-term ambitions are extensive. It wants to become one of the largest food surplus retailers in Europe by working with more brands across more categories.

Simpson said the founders both know this is possible. [We are] well on the way to achieving the long-term goals to help even more brands find a home for their surplus, and get even more consumers used to the idea of shopping for surplus food alternatives.

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Product showcase 2020: From No bake Energizing Oat Bites to the ultimate almond flour – BakeryAndSnacks.com

Heart healthy

Natures Eats a family-owned brand of Texas Star Nut & Food Company is launching an almond flour that performs just like traditional all-purpose flour.

According to the company, the Ultimate Nut Flour: Almond+ a proprietary blend of almond flour and other natural ingredients will also rise better than other almond flours on the market.

The one to one almond flour mix is non-GMO, kosher-Star K certified and has an enhanced bake and rise formula, which means no need for conversion tables as all ingredients are included and ready to use. The flour can easily be substituted in existing recipes to make gluten-free crackers, breads, cookies or doughnuts.

Suitable for keto, paleo and gluten-, grain- and wheat-free diets, almond flour is cholesterol free, low in carbs and high in protein: One ounce of almond flour contains over 6g of protein and 3g of fibre. It is also rich in magnesium, vitamin E, manganese, copper and phosphorus.

Natures Eats is committed to showcasing the benefits of nut flours in new and innovative ways, said John Taylor, president and CEO for Natures Eats.

The Ultimate Nut Flour: Almond+ will bring new life to baking by enhancing taste, usability, performance, versatility and product longevity. Were excited to bring a key ingredient for innovative cooking to match market demand and expected growth.

The 16oz convenient re-closable bags of Ultimate Nut Flour: Almond+ will be launched exclusively on Amazon in August 2020 with nationwide store availability in 2021.

Munchy Seeds has won a listing in Wholefoods Markets seven London-based outlets with three of its variants Honey Roasted, Mega Omega and Sweet Chilli in 125g sharing bags.

According to the Suffolk-based snack producer, its Munchy Seeds are a perfect fit for Wholefoods customer base, as they are 100% natural, gluten and dairy free and suitable for vegetarians. Five flavours in the range are also vegan.

We are delighted to be working with Wholefoods Market and supplying such prolific stores in the capital, said Lucinda Clay, co-founder of Munchy Seeds.

We feel that Munchy Seeds and Wholefoods Market are a brilliant match as we share a passion for high quality, locally-sourced products that can be enjoyed as part of a healthy lifestyle.

Munchy Seeds produces a range of seed mixes in six sweet and savoury flavours: Sweet Chilli, Mega Omega, Honey Roasted, Warm Cinnamon, Mild Chilli and Salted Caramel, in three formats: 25g snack packs (RRP 80p), 120g resealable pouches (RRP 2.99) and 450g resealable sharing packs (RRP 8.75).

Fatherson Bakery has launched three premium fours available on its online platform and delivered to your doorstep including Fatherson Premium Plain Flour, Self-Raising Flour and Strong Bread Flour.

The flours are milled and packed in the UK and have smart packaging to stop flour mess getting everywhere with their easy to open and close resealable packaging. The inside foil wall packaging helps to keep the flour fresh over its 12-month shelf life.

People are falling back in love with baking, and while we are spending more time around the home its the ideal time to try new recipes or even experiment, said Laurence Smith, owner of Fatherson Bakery.

Our new range of flours will meet every bakers dreams. The flour range is a best in quality, signature flour, milled from British crops that we use in our very own baking daily. As a result, people will be able to enjoy delicious results.

The flours each come with a recipe suggestion, are natural, contain no preservatives and are suitable for vegetarians and vegans. Available in 1.5kg bags with a RRP of 2.75-2.95.

Baking mix brand Krusteaz has launched its newest innovation, Energizing Oat Bites Mix.

Available in two varieties Chocolate Chip Oat and Cinnamon Oat the products require no baking and feature whole grain oats, flaxseed and chia.

The mixes are made without artificial flavours, artificial colours or artificial preservatives and contain 8g of plant-based protein per serving.

After the great success of our protein and whole-grain line of pancakes, muffins and cornbread, we were eager to provide consumers with options for convenient anytime snacking, said Andy Heily, president & CEO of brand owner Continental Mills.

At Krusteaz, we believe that nutritious protein-filled snacks dont have to sacrifice great taste, so were excited to continue to add more products that combine the energising benefits of whole grains and protein with the classic taste that consumers expect from the brand.

The Oat Bites Mix is easy to make in just 30 minutes and can be glammed up with nut or seed butters, honey or agave and rolled in chopped nuts or flaked coconut.

Available at Walmart across the US with a RRP of $3.99.

Organic and gluten-free brand Jovial Foods has launched a cassava flour pasta, the first of its kind on the market.

Available in five shapes Spaghetti, Fusilli, Penne, Elbows and Orzo the cassava pasta is crafted in Italy by artisan pasta makers, using traditional techniques and two simple ingredients: organic cassava flour and water.

The plant-based, grain-free line is also free of the top 8 allergens, as well as gluten and gums, and has no added starches, making it suitable for any lifestyle.

Jovials cassava pasta can be found across the US at Sprouts, Wegmans, Heinens and online with planned expansion to Amazon, Thrive Market, Whole Foods and Hannaford soon at a RRP of $4.99.

Carla Bartolucci, founder of Jovial Foods, found that cassava could make a high-fibre and nutrient dense pasta that satisfies like real pasta. It is also aligned to Jovials mission of sustainable farming, growing in marginal soil with little water and producing more calories per acre than wheat and corn, making it a staple for over half a billion people worldwide.

Quinn Foods, known for reimagining classic snacks with real, transparent, great tasting ingredients, has launched Grain Free Pretzel Chips, made from cassava flour, also known as yuca.

The chips are non-GMO, certified gluten-free, grain- and dairy-free, and suitable for Paleo and vegan lifestyles.

The plant-based chips are baked not fried and seasoned with rock salt. They contain 2g of protein and fibre, along with only 100 calories per serving.

At Quinn, we want everyone to be able to enjoy the mouth-watering flavour and texture of pretzels regardless of special diets or restrictions, said Kristy Lewis, founder and CEO of Quinn Foods.

Our grain free, pretzel chips allow so many people with allergies or special diets, the chance to enjoy the nostalgic taste of pretzels once again.

Quinns Grain Free Pretzel Chips are available at Whole Foods Market stores across the US and also on Amazon.

UK bakery Patisserie Valerie has created a Thank You Cake for people to show their appreciation for those who have gone above and beyond during the UKs lockdown period, with 10% of proceeds being donated to Silver Stories.

Silver Stories links young readers with elderly people many of whom who are in care homes to enable them to read to them over the phone. The charity was created in response to knowledge concerning the loneliness that can be felt by the elderly in the community and their often separation from the younger generation.

Many people have come together in recent weeks during the coronavirus crisis to support each other in communities throughout the UK and Patisserie Valeries cake provides an opportunity to say Thank You.

It can be ordered online for delivery direct from the bakery to any postcode in the UK. Order by midday for next day delivery, where available.

The Great British Porridge Co. has furthered its listing with Ocado to include two new flavours to its 385g 7-serving bag range, as well as its recently launched 60g porridge pots.

The new Caffe Latte and Classic Chocolate porridges in bags, and range of convenient single serve porridge pots in Classic Chocolate, Bl
ueberry & Banana and Caffe Latte are all 100% natural, contain no added sugar and are suitable for vegans and those following gluten-free diets.

We are very excited to be able to offer all of our products on Ocado, said Jacqueline Barleycorn, founder of The Great British Porridge Co.

Launching a new range during lockdown has proved hard work, particularly in creating new retail relationships, so securing our offer on Ocado so quickly is just fantastic.

We have built up a loyal Ocado customer base over the years, so its great to be able to give our customers even more choice.

The Great British Porridge Co. 385g bags have an RRP of 3.99 (also available in Banana & Blueberry, Strawberry & Peanut Butter and Red Berry & Pumpkin Seed), while the porridge pots have an RRP of an RRP of 1.29.

Razor USA has kick-started scooter culture and design to the next level with its first-ever limited-edition collaboration series, featuring Takis Snacks-themed kick scooters. The company also partnered with Sriracha, AriZona Iced Tea and Sharpie for the collection, with each collaboration injecting the essence and personality of the four hip brands via visual styling and colourways.

According to Takis Snacks brand owner Barcel USA the US snack division of Grupo Bimbo its rolled tortilla chips are no ordinary corn chips. Available in five punchy flavours Fuego, Crunchy Fajitas, Nitro, Wild and Guacamole they have been created for the strong, brave and daring.

Razors Takis Snacks scooter brings that boldness to life with its purple body and T-bar, contrasted with striking yellow wheels.

When Razor launched twenty years ago, our goal was, and still is, to inspire joy, excitement, and fun everywhere our riders go, said Jim Wagner, president of Razor USA.

To be able to collaborate with such culturally influential brands that align with these values is a testament to the breadth and ability of Razors influence in this space of iconic brands, and we cant wait to see where this collaboration takes Razor in the future.

The themed scooters are available at select Target locations as well as online only while supplies last.

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Product showcase 2020: From No bake Energizing Oat Bites to the ultimate almond flour - BakeryAndSnacks.com

Attractive Market Opportunities in the Pumpkin Powder Market by 2028 – Cole of Duty

Pumpkin Powder: Market Outlook

Pumpkin powder is derived from dried pumpkins that are grounded in powder form by using various techniques such as freeze dried, spray dried, and others. Moreover, while preparing organic pumpkin powder, organic pumpkin is used and no artificial colors, preservatives, or any other processing agents are used is the manufacturing process. Pumpkin powder is the best source of healthy nutrition as pumpkin powder enriched with high fiber, potassium, vitamins, and other nutritional ingredients. Owing to its health benefits and as a flavored ingredient, the demand for pumpkin powder is increasing among the food and beverage industry, dietary supplements, and others. In terms of health benefits, pumpkin powder is advantageous to reinforce the digestion system, prevents the increasing level of blood sugar and blood fat, helps in detoxification, boost the immune system, and others. On the other side, the demand for pumpkin powder is also increasing among food and beverage manufacturers as it has wide application in bakery products, snacks, baby food, sauces and dressings, confectionery, and many other products.

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Increasing Demand for Pumpkin Powder in Nutritional Supplements Owing to its Varied Health Benifits

Pumpkin powder is rich in protein, carbohydrates, dietary fiber, carotene, vitamins, pectin, iron, magnesium, potassium, and many other ingredients that offer health benefits. In food and beverage industry, pumpkin powder is used to add flavors in bakery products, as a colorant in snacks, seasoning sauces, and other food products to add higher nutritional content and natural pumpkin flavor to products. Consumers are inclining towards maintaining a healthy lifestyle, which has led to higher consumption of food and food ingredients with potential health benefits. Currently, consumers have become more conscious about their diet, owing to which, they are spending on a holistic approach to health and wellness that includes almost every aspect of life. Additionally, consumers are increasingly participating in fitness activities that enhance well-being, such as using products, eating natural and organic foods, and consuming health supplements, along with following a special diet owing to which it is expected that the demand for organic pumpkin powder is an increase among functional food and dietary supplements manufacturers. Thus, the market for pumpkin powder has high demand in Western Europe and Asia Pacific countries, owing to an increase in the health and wellness awareness among the population, along with the growing number of highly affluent consumers who are interested in the trend for healthy food.

Global Pumpkin Powder: Market Segmentation

In terms of Nature, the global pumpkin powder has been segmented as:

In terms of End-use, the global pumpkin powder has been segmented as:

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Global Pumpkin Powder: Market Participants

The market for pumpkin powder is rapidly growing. Some of the key players of pumpkin powder are AUM AGRI FREEZE FOODS, Arisun Chempharm Co., Ltd., Cedenco Foods , Nutragreenlife Biotechnology Co. Ltd., Linwoods, Woodland Foods, Yuensun Biological Technology Co., Ltd., SpicesForLess, and others are some of the major manufacturers of pumpkin powder.

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Attractive Market Opportunities in the Pumpkin Powder Market by 2028 - Cole of Duty

Phosphatidylserine Market Analysis Growth Opportunities and Demand Drives by 2018 to 2028 – Cole of Duty

Global Phosphatidylserine Market: Overview

The global phosphatidylserine market is gaining traction, owing to the convenience it provides to older individuals for improving memory. Phosphatidylserine is a compound derived from amino acid which is very similar to a dietary fat. This dietary fat is highly found in humans neural tissue. Phosphatidylserine can be found in the form of white or light yellow loose powder and also sometimes can be obtained in liquid state. This amino acid derivative compound is highly crucial for various cognitive functions. Phosphatidylserine can be naturally found from cabbage and soy derivatives and extensively used as a functional food or important dietary supplement.

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A report on the global phosphatidylserine market to be added to the vast repository of TMR Research presents thorough information on it. The report could be a valuable guideline for major stakeholders in the market. This study has been carried out through an in-depth primary and secondary research. The report can help players gain knowledge about the opportunities and pitfalls in the phosphatidylserine market, so that they can take informed decisions. The report also highlights growth drivers and restraints in the global phosphatidylserine market.

Global Phosphatidylserine Market: Trends and Opportunities

Phosphatidylserine supplements are highly useful for fighting various age-related cognitive declines such as Alzheimers and dementia. Such compound is also widely adopted as a reliable and safe remedy in healthcare industry due to its efficacy in treating various neurological disorders such as ADHD (Attention deficit hyperactivity disorder). Such USPs are believed to be driving the global phosphatidylserine market. Rising population suffering from cognitive impairment, and growing demand for natural products in enhancing cognitive functionalities are also the major factors expected to fuel demand in the global phosphatidylserine market.

Furthermore, phosphatidylserine is considered as an ideal solution for brain health. Moreover, compared to other available products, phosphatidylserine offers more clinically-proven long-term health benefits. Rising consumer adherence to healthy diets, and growing demand for cognitive well-being are also expected to boost the global phosphatidylserine market. Phosphatidylserine is naturally present in various animals and plants such as Antarctic mackerel, cows, fish roe, sunflower, and krill oil. Such compound is mainly synthesized in the human brain, and helps in transporting neural signals along with protecting neural tissues. Rapid lifestyle change, growing peoples inclination towards healthy lifestyle, and increasing consumer demand for foods with multifarious health benefits are also projected to propel growth in the global phosphatidylserine market.

However, high costs and low availability of phosphatidylserine may hinder the growth of the global phosphatidylserine market. Nonetheless, such deterrents may not impact the momentum expected in the global lateral epicondylitis treatment market in the near term.

Global Phosphatidylserine Market: Market Potential

At present, the demand for organic phosphatidylserine is rising day by day due to its multipronged health benefits. Such compound is extensively used in multiple varieties of functional foods such as breakfast cereals, processed fruit juice, and nutritional bars. Apart from healthcare industry, organic phosphatidylserine is also highly adopted in various end-use industries such as cosmetic industry. Growing demand for slowdown skin aging, and rising need for potential moisturizer is expected to fuel demand of phosphatidylserine in the cosmetic industry, which in turn is anticipated to boost the global phosphatidylserine market.

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Global Phosphatidylserine Market: Regional Outlook

Geographically, Asia Pacific is expected to lead the global phosphatidylserine market as the region has seen rapid establishment of food manufacturers. The prominent country in this region is China. Large food market, rapid establishment of local brands, and rapid advancements of phosphatidylserine production technology could also be responsible for fueling phosphatidylserine market in this country.

Global Phosphatidylserine Market: Competitive Landscape

Some of the prominent players operating in the global phosphatidylserine market are Lipoid, Chemi Nutra, Enzymotec, Lonza, Sino Herb, Novastell, and BHN.

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Phosphatidylserine Market Analysis Growth Opportunities and Demand Drives by 2018 to 2028 - Cole of Duty

Richmond woman in race to be Maxim Cover Girl 2020 – Richmond News

A Richmond woman is in the hunt to win the cover girl contest for one of the worlds top lifestyle magazines.

Mercedes Ciprut is currently in the top one per cent of voting for the race to be Maxim Cover Girl 2020, with voting for the quarter final stage ending tonight at 8 p.m.

The 30-year-old self-confessed workaholic prides herself in having a super healthy lifestyle - which includes some body-building but has never entered any such contest before and is astounded by how far shes come.

And the nursing student, who also works as a server at the Pioneer Pub in Richmond and as a lab technician at BC Childrens Hospital, is now eyeing up a place in the semi-finals and the $25,000 (U.S.) first prize, which comes with a cover shoot and two-page spread.

I'm looking for support in the local community to help me win a contest, said Ciprut, who gets up daily at 4:30 a.m. to work out for more than hours at the World Champion Club gym at the foot of No. 5 Road.

This competition has been going on since May and I was a strong leader in my group rounds, but now as I'm amongst the top one per centit's getting very tough.

This is the first time ever Ive tried to be competitive, but I wanted the grand prize for my schooling and to see what I was capable of.

Ciprut said the contest just popped up on her Instagram feed one day and she decided, on a whim, to go for it.

I try my best to stay away from the body-builder image. Im really the opposite of that; theres a softer, sweet side to me and Im hoping that taking part in this would show that side, she added.

I just want to show a more feminine side by doing this. I do like girly things as well.

If she wins, Ciprut said she will donate $5,000 of the grand prize to a Richmond charity, take her mom out for dinner and put the rest towards her nursing courses.

To vote for Ciprut, go to https://maximcovergirl.com/2020/mercedes-ciprut.

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Richmond woman in race to be Maxim Cover Girl 2020 - Richmond News

Mother, 51, works out 20 times a week to outdo her 20s body – Brinkwire

A super-fit 51-year-old mother has revealed the secret to her incredible physique that she says is better than it ever was when she was in her 20s.

Southern California-based fitness trainer Lynn Montoya regularly helps her clients get into tip-top shape with her personalized training programs, regardless of their age ensuring other women in their 50s can achieve the bodies of their dreams.

Lynn works out a staggering 20 times a week in order to maintain her own figure however she says that every woman has the ability to achieve the same results, as long as they are willing to dedicate themselves to living a healthy and active lifestyle.

The stunner particularly likes to focus on helping middle-aged women get stronger and happier with in-person and virtual training sessions, helping them to get in the best shape of their lives.

Speaking to Jam Press, Lynn explained, We women are conditioned to believe that as we age, we need to take it easy and that workouts need to be slow-paced and humdrum. I believe just the opposite.

I have my clients eat only clean real food, train them hard, and the results are incredible.

Lynn works out an impressive 20 times per week, as well as teaching corporate fitness, private fitness classes and spin classes.

She was already fairly well known in the Southern California area, but since launching her Instagram pageshes amassed a whopping 44,100 followers thanks to her fitness tips, workout videos and saucy photos.

The stunner said her posts on the social media site are about empowering women to be strong in their 50s and beyond and are mixed with a healthy serving of creative content, recipes and a dose of racy photos that surely entice male followers to stay engaged.

As well as sharing exercises to improve health and fitness, Lynn also reveals how workouts can improve other areas of your lifestyle including your sex life.

Science suggests lifting weights improves sex drive by encouraging your body to produce more testosterone, she wrote in a recent Instagram post.

Since healthy testosterone levels are associated with sexual desire, doing exercises that can increase testosterone may also amp up your libido.

If you already do some type of strength training as part of your fitness routine, some minor tweaks may be all you need to ensure youre maximizing your testosterone-producing potential.

Experts suggest the following three tips to get the most out of your weight lifting session: Working all the major muscle groups, especially your legs (the largest in the body); Doing fewer reps with heavier weights; Shortening your rest time between sets.

She continued: Intense cardiovascular exercise like HIIT is an excellent way to blow off steam because it lowers levels of the stress hormone cortisol in your body. Elevated cortisol has been shown to significantly reduce testosterone, so keeping your stress in check is crucial for maintaining a healthy sex drive.

Strength train at least 3X and HIIT 2x a week to keep your libido riding high!

Lynn also wants women to realize the importance of a healthy lifestyle when it comes to avoiding illness as they age, explaining in a recent Instagram post that maintaining a healthy weight is key for maintaining good health.

Staying at a healthy weight is one of the most important things you can do to reduce your risk for cancer, she wrote.

When it comes to cancer, the only thing more important than maintaining a healthy weight, is not smoking. This is because excess weight causes inflammation and hormonal imbalance.

If you are overweight or obese, your risk is higher for 12 different types of cancer including colorectal, post-menopausal breast, uterine, esophageal, kidney and pancreatic cancers.

However, if you eat mostly plants, you remove many of the foods that lead to weight gain. Add in exercise and youre on a path towards weight loss and a healthier life.

Lynn also runs a YouTube channel which features over 100 workouts designed for at-home use.

As if that wasnt enough, shes also just managed to complete the Burpee Challenge, which has gone viral online.

The goal to be considered an athlete is 12 minutes, and times under eight minutes are extremely rare, that is until now.

But the mom, who is eligible for American Association of Retired Persons (AARP) membership, managed to rack up a whopping 100 of the exhausting burpees in just over six amazing minutes, cutting that time in half.

My mission is to prove to middle-age women that you can be strong and sexy at any age, she explained.

The path is simple its strength training, HIIT workouts, eating clean and getting your hormones checked yearly,

The rest is here:
Mother, 51, works out 20 times a week to outdo her 20s body - Brinkwire

NHS wellbeing app launches for cancer patients – Med-Tech Innovation

A new app with content developed by staff at an NHS Trust in the North East aims to support patients during and following cancer treatment.

The app, My Wellbeing Space, is a digital service from NHS partnership Health Call and technology provider Inhealthcare and funded by the Northern Cancer Alliance. It will initially be available to patients receiving care from County Durham and Darlington NHS Foundation Trust. The content was developed by the Macmillan project team in collaboration with clinical teams and involving patients at all stages of its design and testing.

Clare Doney, Macmillan lead cancer nurse, said: Being diagnosed with cancer is a life-changing event affecting patients, families and friends emotionally as well as physically.We want to provide holistic support as soon as possible and the app is one way that we can reach out to more people. It gives our patients tools and resources to support and empower them to contribute to their wellbeing and overall health.

The My Wellbeing Space app provides advice and links with content including information about: physical activity, late effects of treatment, food and nutrition, financial concerns, fatigue, emotional wellbeing and treatments.It also includes short video clips delivered by a consultant, clinical nurse specialist, wellbeing practitioners, GP, oncologist, a patient and carer.Patients will be given access to the app during their treatment.

Tina Murray, from Neasham, near Darlington, who completed two and a half years of treatment for cancer earlier this year, said: Coming towards the end of cancer treatment, I felt fear rather than elation. My life had been consumed by appointments, tests, treatments and I feared the loss of that structure.This is when you can start to realise the enormity of what has happened, feel isolated and fear the future. This is where the app comes in. It helps crystallise and identify in your mind the issues you are facing.It provides all sorts of information and sources of support available to you to help you through your emergence from treatment.You can get help dealing with your emotional mental health, as well as physical issues such as fatigue and where to get support for financial concerns. The app is very simple to use and because the support information is tailored to your local area, very relevant.

Bryn Sage, chief executive at technology provider Inhealthcare, said: This is a great example of how health technology can support people living with long-term conditions, especially during the Coronavirus pandemic. As well as providing reassurance to patients, My Wellbeing Space also promotes a healthy lifestyle which can help the body to recover after cancer treatment.

Health Call plans to share the app more widely through Trusts across the North East and North Cumbria.

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NHS wellbeing app launches for cancer patients - Med-Tech Innovation

Why Generation X is a health timebomb – shropshirestar.com

For all the talk about childhood obesity, it seems that Generation X born in the 1960s and 70s is in no position to dish out the lectures. Because a new study by University College London says that while today's middle-aged folk may live longer, they are in far worse shape than the Baby-Boomers who went before them.

The study, which looked at 35,189 people aged between 25 and 64 who took part in the annual Health Survey of England between 1991 and 2014, found that conditions such as diabetes and obesity were far more prevalent among people born in the 1960s and 70s than those born shortly after the war.

This probably does not come as a huge surprise to us Generation X-ers. While the early Baby-Boomers spent their formative years in an era of postwar austerity when rationing was still in place and the Dig for Victory mindset was still fresh in the mind, our generation grew up in the age of conspicuous consumption. While our parents grew up on a diet of fresh fruit and vegetables, Generation X was the generation which could eat anything it wanted. And we chose to use that liberty by gorging on Space Dust, Corona orangeade and Aztec bars.

While housewives in the 1940s and 50s would walk up to their local greengrocer and butcher each day, Generation X grew up just as these small businesses were being replaced by the supermarkets, when ready-meals were becoming de rigeur, and when the must-have status symbol was a giant chest freezer, followed a few years later by the microwave oven.

And then there was television. While today's older generation would have spent their childhoods enjoying healthy outdoor activities, today's forty- and fifty-somethings chose to stay in the house glued to the Clangers and Rentaghost.

But it's not all down to our mis-spent childhood. Children of the 60s and 70s are also far more likely to lead sedentary lives, in no small part due to a change in the way we work.

Perhaps contrary to popular belief, the service sector has actually dominated the UK economy for the past 100 years, but there is no doubt that we are more likely to earn a living sat at a desk than we were half a century ago. In 1965, the primary sector, made up mainly of agriculture and mining, accounted for 5.5 per cent of the labour force, and manufacturing and construction 40 per cent, with the remainder working in the service sector. But by 2016, the primary sector had fallen to 1.3 per cent, and manufacturing and construction had dropped to 15.1 per cent, with 83.6 per cent working in the service sector. So many people who might in the past have done physical jobs in a factory or field now find themselves sat behind a computer screen.

Dr Satya Sharma, a retired Black Country GP, says the research confirms what he had suspected for many years. And the bleak news is that he fears that the next generation, the Millennials, will suffer even more problems in the future.

"I think the young generation have a less healthy lifestyle," he says.

"Instead of thinking about their health, they think more in terms of wanting to enjoy themselves, and their definition of enjoying themselves seems to be going out to eat, or doing things like going to the cinema."

Some health conditions may be down to people living longer, he says. For example, the likelihood of developing diabetes increases as we get older, as our insulin levels decline. But the most striking thing about the UCL study is that people in their 40s and 50s today are far more likely to have health problems than people their age would have done a generation before.

Later-born cohorts were more likely to have diabetes, to be overweight and to report having cardiovascular disease and poor health in general while later-born men were more likely to report high blood pressure, it adds.

Professor George Ploubidis, the senior author of the report, says: "Earlier in the 20th century, a rise in life expectancy went hand in hand with an increase in healthy lifespan - younger generations were living longer, healthier lives.

"It appears that, for those generations born between 1945 and 1980, this trend has stalled. Those born later are expected to live longer on average, but with more years of ill health."

This is not only bad news for Generation X, but it could be catastrophic for the National Health Service as it has to find the resources to cope with an ever-increasing ageing population with more and more health problems. This may be why Boris Johnson by his own admission, an overweight 56-year-old is looking at banning two-for-one offers on junk food.

Dr Sharma, a very fit 70-year-old Baby Boomer, says the findings back up research carried out some years ago in Bilston and Low Hill, Wolverhampton, which found growing rates of obesity among children.

He also believes that today's fast-paced, high-pressure, social-media dominated world is placing a greater strain on people's mental health, which is very often the underlying cause of poor physical mental health.

"A lot of the problems talked about, such as high blood pressure, are caused by mental health problems," says Dr Sharma.

"We live in a time now where people will apologise for taking three hours to get back to someone. What is there something to apologise for?

"You might have three cars, but if you are unhappy, do those cars improve your happiness? It's the people you have around you that make you happy.

"People don't seem to talk to friends and family they way they used to, young people seem to be more self-centred, they live in their own little world with their iPad or social media."

The positive news is that medical treatments have made huge advances over the past half century, and many of the conditions can be managed. That is why a boy born in 2018 can expect to live to 79.6 years old, while a girl should manage 83.6 years.

But Dr Sharma points out that quality of life is just as important as quantity.

"Living longer is not necessarily a blessing if you are going to spend those extra years in poor health."

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Why Generation X is a health timebomb - shropshirestar.com

Chef Renu Dalal: Vegetarian food is dynamic, exciting and more popular than ever – The Indian Express

Written by Shambhavi Dutta | New Delhi | Published: July 17, 2020 12:30:39 pm Chef Renu Dalal says she has always believed that cooking comes from the heart and soul if you do it with love, the end result is so much better. (Photo: PR Handout)

Food writer Laurie Colwin once said, No one who cooks, cooks alone. Even at her most solitary, a cook in the kitchen is surrounded by generations of cooks past, the advice and menus of cooks present, the wisdom of cookbook writers. This is true for chef Renu Dalal, who has proudly carried forward her mother and legendary chef Tarla Dalals legacy, something she admits, was not really the plan.

In conversation with indianexpress.com, the author talks about the constant presence of exceptional dishes at home, her upcoming book, what cooking means to her, how vegetarianism will be the next big thing and why fusion dishes are here to stay.

Excerpts from the interview:

Growing up with a legendary chef as your mother, what does cooking mean to you?

As a child, fabulous food was a constant presence in our home. My mother held cooking classes, and the highlight of my day used to be tasting all of the dishes she had prepared, after coming home from school. Our house also used to play host to shooting sessions for each new cookbook, which was something I looked forward to. My mother always encouraged an interest in cooking, so much so that I even took a cooking class when I was young, under her supervision.

Cooking is my joy and passion. It fills me with energy, and my greatest joy is creating something new in the kitchen. I also love the wonderful feedback I receive when my readers make one of my recipes, and the happiness and nourishment I share with them.

Was it always your plan to take forward the Tarla Dalal legacy?

It was never really my plan to take forward her legacy. However, a few months after she passed away, I began to think of new recipes. My mother, an endless source of new and exciting recipes, was no longer around to share her wisdom. It is also a tradition in my family to not repeat menus. Whenever friends and family come over, something new is always on the table. And so, every time I tasted something I liked, I would think, How can I make that?

I began to put these recipes down in an excel spreadsheet and thats how I began writing! The wonderful feedback and reviews I received from friends and family encouraged me. Ive now written two books, and have a third one in the works.My recipes are simple and inventive and I plan to continue as long as inspiration strikes.

READ| Chef Vicky Ratnani: Post-Covid, overall hygiene will be of utmost importance and very rightly so

Could you share your favourite dish from childhood?

When it comes to my mothers cooking, picking just one favourite is quite the task. But if I had to choose, it would be her baked bean and spinach pizza. Amazing flavours and childhood nostalgia, all wrapped up in one dish. Her cooking was always ahead of its time. The ingredients she used, the simple and easy-to-follow steps, and the ways in which she combined flavours were all unparalleled. Thats why her recipes continue to remain so popular, and no dish better represents all of these elements than this pizza. Ive used the same ingredients to create a grilled baked bean and spinach sandwich, which has been quite the hit at family events.

READ| India on its way to being the next big thing in the specialty coffee world: Sherri Johns

Baked Beans and Spinach Sandwich recipe

For the baked beans filling:

For the spinach filling:

For grilling:

For the bean filling

For the spinach

How to proceed

How to serve

READ| The best Butter Chicken in India is in Delhi, Ive been told: Marco Pierre White

For people in quarantine, should they look at cooking as a hobby or an essential activity to survive?

Cooking comes from the heart and soul if you do it with love, the end result is so much better. With the ingredients and tools that we now have access to, Indian kitchens are as well-equipped as any in the world.The ability to cook has become more important than ever during this quarantine, one that will prove useful long after this situation ends. Cooking is also a fantastic form of self-therapy. The act of preparing a meal with your own two hands, especially if you share it with friends and family, is one of the most satisfying and fulfilling feelings in the world.

Do you have any favourite quarantine food trends that have taken the internet by the storm?

Quarantine has brought out the creativity in many people, and there are quite a few fantastic trends that have popped up. Three and even two-ingredient recipes that are simple and delicious have taken the internet by storm, and a few have become personal favourites. Home baking has also taken off, with everyone trying their hand at bread, cookies, and cakes myself included. Immunity boosting foods is another favourite, and healthy foods as a whole have seen renewed interest.

READ| Chef Vikas Khanna: Our cuisine needs more time to establish itself

Many believe that vegetarian food can sometimes get monotonous. Any tips?

Nothing could be further from the truth! Vegetarian and vegan food today is dynamic, exciting, and growing faster than ever before, both in India and globally. There used to be a time when travelling abroad meant hunting for the lone vegetarian restaurant in a city. Today, dedicated vegetarian restaurants can be found just about anywhere in the world. Many of these changes are due to the growing knowledge of the benefits of a vegetarian diet. Netflix has even produced a fascinating documentary called The Game Changers, which showcases how top athletes have adopted vegetarianism thanks to its nutritional and health benefits. My mother was one of the earliest pioneers of vegetarianism and really showcased its range and depth.

Two key factors to a successful vegetarian dish are its presentation and taste. The first convinces people to take a bite, and the second makes them want to keep eating! Always try to put something new on the table your effort will never go waste.

Any fusion dishes you can mention, which capture both Indian and western flavours?

The Indian palate is always looking for something new to eat dressed up in familiar flavours.My travels have given me the chance to try many new foods and flavours, and I love incorporating them into my own recipes. Ive featured quite a few of these interesting pairings in my books. My favourites are waffle idli delight, Mexican panipuri, chocolate panipuri, spaghetti with lentils, khakra pizza, and Thai paan. They all taste delicious and bring something new to the table. One pairing Im especially fond of is masala paneer with peach sauce the combination of sweet and salty is out of this world!

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Chef Renu Dalal: Vegetarian food is dynamic, exciting and more popular than ever - The Indian Express

Vegan Baking Ingredients Market Industry Production and Demand, Competition News and Trends Forecasts to 2018 to 2028 – 3rd Watch News

An exclusive market study published by Fact.MR on the Vegan Baking Ingredients market offers insights related to how the market is projected to grow over the forecast period (2019-2029). The objective of the report is to enable our readers to understand the various aspects of the Vegan Baking Ingredients market and assist them to formulate impactful business strategies. Furthermore, the different factors that are expected to influence the current and future dynamics of the Vegan Baking Ingredients market are discussed in the presented study.

According to the report, the Vegan Baking Ingredients market is set to reach a market value of ~US$ XX by the end of 2029 and register a CAGR growth of ~XX% during the assessment period. The report offers an in-depth understanding of the Vegan Baking Ingredients supply chain, value, and volume chain across the various regional markets.

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Vegan Baking Ingredients Market Segmentation

By Region

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The report offers a clear picture of how the Vegan Baking Ingredients is utilized in various applications. The different applications covered in the report include:

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competitive landscape, get in touch with our experts

Players to Benefit from Uptake of Egg Replacement Ingredients

The avian influenza outbreak and its extended prevalence among birds is creating a shortage in supply of eggs worldwide. The epidemic is causing seasonal fluctuations in the prices of eggs. Further, consumers across Europe and the USA are increasingly preferring bakery goods manufactured using egg alternatives, after traces of fipronil were found in eggs in 2017 and 2018. European Union is expected to levy high import charges on egg powder in 2019 making it a high priced ingredient for use in baking. Baking industry is gradually shifting to using egg replacement ingredients in the production of their goods to shield themselves from the egg price volatility and lure in more consumers. With veganism gaining a pervasive prevalence, and consumers associating health benefits with consumption of plant-based and animal-free products, demand for vegan baking ingredients is expected to rise.

Sales Underpinned by Innovation in Ingredients Manufacturing

Baking industry is struggling to produce quality vegan baked goods, owing to the loss of functionality, texture, and mouthfeel that eggs provide. Finding ingredients that can potentially replace eggs in vegan baked goods limits the scope of development for the baking industry. However, innovations in vegan baking ingredient manufacturing are slowly enabling bakeries to bridge the gap between vegan baked goods and normal bakery items. Numerous companies are working towards the production of vegan baking ingredients that could mimic the texture and taste of bakery products. For instance, KaTech, a leading manufacturer of stabilizers and emulsifies, announced the launch of new bakery concepts tailored to address the shortcomings in the vegan bakery ingredients. The company launched an assortment of alternative dairy fillings in different variants such as low-fat and reduced sugar to meet the burgeoning demand for healthier vegan bakery products.

Powdered egg replacers are being manufactured to provide enhanced texture, as they are capable of adding fluffiness in addition to providing the medium required to bind ingredients in bakery products. Additionally, vegan baking ingredients manufacturers are working towards the development of stabilizers that provide for a better texture and mouthfeel. The increasing number of innovations are estimated to meet the diverse demand of consumers and aid in vegan baking ingredients market proliferation.

Demand Surges in Line With Large Scale Production and Launch of Vegan Bakery Chains

A substantial increase in the number of people following veganism, coupled with a rise in the overall demand for vegan bakery products has led food processing companies to adopt large-scale production. For instance, Greggs, a leading bakery chain based in Britain recently reported a shortage in supply of its new product offering in vegan sausage rolls alluding to the surging demand for vegan bakery products. The sudden increase in the demand for vegan bakery goods is prompting new installments of all-vegan bakeries around the world. E-commerce giants announced the launch of an all-vegan online baking store in 2018 after witnessing the massive demand for the products during the Great British Bake Off Week. To capitalize on the growing demand for vegan bakery products, existing bakeries are also launching new vegan product lines. Large scale investments in all-vegan baking stores are estimated to bolster the demand for vegan baking ingredients.

Sustainability Prevails as a Key Growth Determinant

Growing awareness about the relationship between food production and its impact on the environment is prompting consumers to shift towards brands that incorporate sustainable solutions in food processing and manufacturing. Although vegan baking ingredients conform to ethical concerns regarding animal treatment, manufacturers are increasingly focusing on streamlining their supply chain operations to keep consumers informed of their sustainable practices and promote sales. A recent development alluding high traction of sustainable practices in the food processing industry is the Icelands ban on palm oil use in vegan bakery products, following reports of child labor, deforestation, and decreasing animal population in Malaysia and Indonesia where it was being sourced from.

Definition

The ingredients derived from plant-based sources which are replacing dairy and animal-based ingredients in bakeries are vegan bakery ingredients. Vegan baking ingredients include products such as vegan milk, vegan butter, egg replacers, vegan baking mixes, and vegan chocolate.

About the Report

The report on vegan baking ingredients market offer all-inclusive and valuable insights into the vegan baking ingredients market. A comprehensive analysis of all the factors influencing the performance of the vegan baking ingredients market has been provided in the report. Additionally, the report provides a detailed opportunity assessment of the vegan baking ingredients market.

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Market Structure

The report on vegan baking ingredients market segments the vegan baking ingredients market on the basis of product type, nature, application, end-use, and region.

Based on product type, the vegan baking ingredients market can be segmented into starch, raising agents, emulsifiers, leavening agents, baking powder and mixes, vegetable oils, colors and flavors, and enzymes.

On the basis of nature, the vegan baking ingredients market can be segmented into organic and conventional.

Based on the application, the vegan baking ingredients market can be segmented into cakes & pastries, biscuits & cookies, bread, rolls & pies, buns, and others.

On the basis of end-use, the vegan baking ingredients market can be segmented into direct sales and residential.

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The report on vegan baking ingredients market is a consequence of robust and elaborate research. A two-step research process was employed to obtain insights into the vegan baking ingredients market. Primary research was conducted by interviewing experts from the vegan baking ingredients market while secondary research involved a thorough study of vegan baking ingredients market trade journals, paid sources, and other publications related to the vegan baking ingredients market. Results from both the steps are cross-referenced to create an authentic forecast of the vegan baking ingredients market.

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Vegan Baking Ingredients Market Industry Production and Demand, Competition News and Trends Forecasts to 2018 to 2028 - 3rd Watch News

Hi John. Will artificial intelligence replace humanity by 2084? – Eternity News

John Lennox is human. As soon as the worlds most recognisable Oxford Professor of Mathematics smiles at me from his UK study via video link, he is apologising for his need to duck off to the bathroom. His immediate physical need arises from not being able to go beforehand, having just finished a one-hour online Q & A session about his newest book, 2084: Artificial Intelligence and the Future of Humanity. Not to be confused with the other book Lennox already put out in 2020 Where is God in a Coronavirus World? or the movie about him to be released later this year.

Tinkering with human beings those ideas interested me. John Lennox

Lennoxs toilet break is an unexpectedly fitting introduction to our conversation about his investigation of artificial intelligence (AI) and what it means for what it means to be human. Riffing on the title of English author George Orwells dystopic novel 1984, 2084 is Lennoxs eloquent and succinct attempt to demystify AI, separate science fiction from science fact, and investigate the ethical and theological questions raised.

But lets cut to the chase of your future-looking book, human. John Lennox, what will the year 2084 be like for people and their intelligent designs? I thought somebody would start with that question, but youre the first interviewer to do it, chuckles Lennox who has been a leading academic Christian in the public square for more than a decade.

Rising to international prominence through viral video debates with new atheist royalty such as Richard Dawkins, Christopher Hitchens and Peter Singer, Lennox also has written many books at the intersection between Christian faith and the philosophy of scientific endeavour and progress.

The whole point is to take off from Orwells book 1984, which gave the English language things like big brother and thoughtcrime. There are aspects of artificial intelligence now that actually are fulfilling the role [from] Orwells 1984.

I wasnt writing the book to tell people whats going to happen in 2084 [but] to tell them to think about what might happen in 2084 or whats liable to happen, because of the developments we already have.

Lennox came to see the need to evaluate the course of artificial intelligence after a London church approached him, several years ago, to speak about how the Book of Genesis relates with AI. Lennox initially declined but was soon intrigued by considering what humanity being made in the image of God (Genesis 1:26) means to the rising tide of artificial intelligence. Since his teenage years in homeland Northern Ireland, Lennox has been interested in big questions such as where does meaning come from and what is the significance of humans in a universe created by God?

My interest was [also] sparked a long time ago by two C.S. Lewis books The Abolition of Man, and the third of his science-fiction book series, That Hideous Strength. Lewis was prescient; he had ideas of, basically, what we now call transhumanism. Those interested me the ideas of tinkering with the germ line, as we would now call it, and tinkering with human beings and producing not humans, but artefacts.

That intrigued me as to where this stuff was going.

At the start of 2084, Lennox admits hes not an AI expert. As an interested and analytical onlooker, he distills where AI is at and might be going, including explaining its two key forms Narrow Artificial Intelligence and Artificial General Intelligence. The former refers to any computer system which can do one thing superbly well that normally takes human intelligence to do; the latter is the transhuman quest for superintelligence, either by enhancing human beings or by creating a humanoid form where, for example, the contents of a human mind could be uploaded. Or much, much more.

Lennox shares what he perceives as positive developments in AI, from a smartwatch that can recognise seizures to online language translators, and algorithms which digitally assist with our daily tasks or needs. He also articulates negatives, flowing mainly from the ethical issues arising from AI. Lennox wonders how often you or I have stopped to realise we carry a portable tracking device with us our smartphone and where our personal data ends up (surveillance capitalism, as Harvard Professor Shoshana Zuboff describes it). What about the human job losses caused by improved artificial intelligence? Or the choice a self-driving car might have to make between crashing into an elderly lady crossing the road or avoiding her but hitting children on the footpath?

People are afraid to say what they really believe about morality. John Lennox

Lennox agrees there is a common view that technological developments always equal positive progress for humanity even though we experience the opposite (such as how advanced warfare or internet access can display the worst in us). Much of his book, 2084, is dedicated to highlighting how artificial intelligence itself is an amoral creation by humans, with moral issues inevitably arising from the real human input into them.

Artificial intelligence is not intelligent at all. It simulates intelligence the word artificial means that the output normally requires human intelligence but in this system, the only intelligence involved which is vastly important is the intelligence of the designers and programmers.

Technological progress is not the same as moral progress; the difficulty is that technology outpaces ethics, says Lennox. So theres an ethical void, which has been dramatically increased by the lack of a common worldview which, for centuries, was Christian in the West, but now were all over the place. And people are afraid to say what they really believe about morality. Thats an absolute tragedy, which is one of the reasons that I like talking about Genesis.

Convinced of the ongoing relevance of the image of God to defining human value and meaning, Lennox also wanted to talk about several popular books anchored in aspects of AI. So much so that Lennox uses bestselling author Dan Browns Origin, as well as Israeli historian Yuval Noah Hararis acclaimed Sapiens and Homo Deus, as structural devices for 2084s points.

Lennox doesnt flinch at being asked if weighing in on an AI novel by controversial and wildly successful writer of The Da Vinci Code was a cheap shot Im interested in what influences millions of people, he explains.

Lennox adds that Hararis input was vital to being able to engage seriously with Browns novel about an AI visionary seeking to scientifically reveal where we came from and where we are going. Hararis books take a more robust, history-based approach to those key questions; History began when humans invented gods and will end when humans become gods, declares Harari.

A superintelligent human already exists. John Lennox

Notably, Homo Deuss advocacy of transhumanism and seeking immortality stirred Lennox at his Christian core. While Lennox doesnt believe Hararis ambition for humans to be able to create actual humans can be achieved Until we know what consciousness is, all talk of that type is pure hype and pure science fiction. We dont know what it is. We havent an idea he was pleasantly surprised to discover how inspired he was by some of what transhumanists seek.

The thing that really turned the corner for me, thinking the book was worth writing, was a sudden and immediate thought that the transhumanist program is too late and its too little because a superintelligent human already exists, says Lennox, alluding to divine man Jesus.

The whole movement of transhumanism assumes were progressing towards [becoming like a god] when actually the movement we ought to be thinking about is the opposite of God becoming man, and providing a basis for a way we could answer Hararis number one problem. The problem of physical death to which the answer is resurrection, not constructing an artificial intelligence

Seeing that there was so much in the transhumanist agenda that really was shadows of the Christian message, I thought Aha, heres a way that I can put Christianity in, perhaps, a rather different way and bring inthings that people normally dont ever do writing a book [about AI].

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Hi John. Will artificial intelligence replace humanity by 2084? - Eternity News

Drs. Oz and Roizen: Vitamin K kick-starts a younger, healthier old age – The Union Leader

Kevin Special K Daley played with the Harlem Globetrotters, and was the body double for a young Michael Jordan in a 2002 Gatorade commercial; Alan Special K Kulwicki was the NASCAR 1986 Rookie of the Year; and pro tennis player Athanasios Special K Kokkinakis defeated No. 1-ranked Roger Federer in the second round of the 2018 Miami Open.

All special for sure, but theyve got nothing on how special vitamin K is when it comes to protecting your longevity. New research out of Tufts Universitys USDA Human Nutrition Research Center on Aging found that older adults with low vitamin K levels (below 0.5 nanomoles per liter) had a 19% higher risk of all-cause death over 13 years when compared with those who had adequate blood levels (more than 1.0 nmol/L).

Whats so special about vitamin K? It is essential for bone and blood vessel health and blood clotting. To make sure you have enough K-power, women 19 and older should consume 90 micrograms daily, men 120. Food sources supply plenty: Half a cup of blueberries delivers 14 mcg; half a cup of edamame, 21 mcg; half a cup of broccoli, 110 mcg; a cup of raw spinach, 145 mcg; and a half a cup of frozen/boiled collards, 530 mcg!

You do make another form of K called K2 (aka menaquinone) in your gut, but little is known about how much is absorbed or what stimulates the production. K2 is also found in fermented foods like nato (fermented soybeans) and sauerkraut. As Dana Carveys Church Lady used to say, Now, isnt that special?

Mehmet Oz, M.D. is host of The Dr. Oz Show, and Mike Roizen, M.D. is Chief Wellness Officer and Chair of Wellness Institute at Cleveland Clinic. To live your healthiest, tune into The Dr. Oz Show or visit http://www.sharecare.com.

2020 Michael Roizen, M.D. and Mehmet Oz, M.D.

Distributed by King Features Syndicate, Inc.

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Drs. Oz and Roizen: Vitamin K kick-starts a younger, healthier old age - The Union Leader

Site-specific glycan analysis of the SARS-CoV-2 spike – Science Magazine

SARS-CoV-2 spike protein, elaborated

Vaccine development for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is focused on the trimeric spike protein that initiates infection. Each protomer in the trimeric spike has 22 glycosylation sites. How these sites are glycosylated may affect which cells the virus can infect and could shield some epitopes from antibody neutralization. Watanabe et al. expressed and purified recombinant glycosylated spike trimers, proteolysed them to yield glycopeptides containing a single glycan, and determined the composition of the glycan sites by mass spectrometry. The analysis provides a benchmark that can be used to measure antigen quality as vaccines and antibody tests are developed.

Science this issue p. 330

The emergence of the betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), represents a considerable threat to global human health. Vaccine development is focused on the principal target of the humoral immune response, the spike (S) glycoprotein, which mediates cell entry and membrane fusion. The SARS-CoV-2 S gene encodes 22 N-linked glycan sequons per protomer, which likely play a role in protein folding and immune evasion. Here, using a site-specific mass spectrometric approach, we reveal the glycan structures on a recombinant SARS-CoV-2 S immunogen. This analysis enables mapping of the glycan-processing states across the trimeric viral spike. We show how SARS-CoV-2 S glycans differ from typical host glycan processing, which may have implications in viral pathobiology and vaccine design.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of coronavirus 2019 (COVID-19) (1, 2), induces fever, severe respiratory illness, and pneumonia. SARS-CoV-2 uses an extensively glycosylated spike (S) protein that protrudes from the viral surface to bind to angiotensin-converting enzyme 2 (ACE2) to mediate host-cell entry (3). The S protein is a trimeric class I fusion protein, composed of two functional subunits, responsible for receptor binding (S1 subunit) and membrane fusion (S2 subunit) (4, 5). The surface of the envelope spike is dominated by host-derived glycans, with each trimer displaying 66 N-linked glycosylation sites. The S protein is a key target in vaccine design efforts (6), and understanding the glycosylation of recombinant viral spikes can reveal fundamental features of viral biology and guide vaccine design strategies (7, 8).

Viral glycosylation has wide-ranging roles in viral pathobiology, including mediating protein folding and stability and shaping viral tropism (9). Glycosylation sites are under selective pressure as they facilitate immune evasion by shielding specific epitopes from antibody neutralization. However, we note the low mutation rate of SARS-CoV-2 and that as yet, there have been no observed mutations to N-linked glycosylation sites (10). Surfaces with an unusually high density of glycans can also enable immune recognition (9, 11, 12). The role of glycosylation in camouflaging immunogenic protein epitopes has been studied for other coronaviruses (10, 13, 14). Coronaviruses form virions by budding into the lumen of endoplasmic reticulumGolgi intermediate compartments (15, 16). However, observations of complex-type glycans on virally derived material suggests that the viral glycoproteins are subjected to Golgi-resident processing enzymes (13, 17).

High viral glycan density and local protein architecture can sterically impair the glycan maturation pathway. Impaired glycan maturation resulting in the presence of oligomannose-type glycans can be a sensitive reporter of native-like protein architecture (8), and site-specific glycan analysis can be used to compare different immunogens and monitor manufacturing processes (18). Additionally, glycosylation can influence the trafficking of recombinant immunogen to germinal centers (19).

To resolve the site-specific glycosylation of the SARS-CoV-2 S protein and visualize the distribution of glycoforms across the protein surface, we expressed and purified three biological replicates of recombinant soluble material in an identical manner to that which was used to obtain the high-resolution cryoelectron microscopy (cryo-EM) structure, albeit without a glycan-processing blockade using kifunensine (4). This variant of the S protein contains all 22 glycans on the SARS-CoV-2 S protein (Fig. 1A). Stabilization of the trimeric prefusion structure was achieved by using the 2P stabilizing mutations (20) at residues 986 and 987, a GSAS (Gly-Ser-Ala-Ser) substitution at the furin cleavage site (residues 682 to 685), and a C-terminal trimerization motif. This helps to maintain quaternary architecture during glycan processing. Before analysis, supernatant containing the recombinant SARS-CoV-2 S was purified by size exclusion chromatography to ensure that only native-like trimeric protein was analyzed (Fig. 1B and fig. S1). The trimeric conformation of the purified material was validated by using negative-stain EM (Fig. 1C).

(A) Schematic representation of the SARS-CoV-2 S glycoprotein. The positions of N-linked glycosylation sequons (N-X-S/T, where X P) are shown as branches (N, Asn; X, any residue; S, Ser; T, Thr; P, Pro). Protein domains are illustrated: N-terminal domain (NTD), receptor binding domain (RBD), fusion peptide (FP), heptad repeat 1 (HR1), central helix (CH), connector domain (CD), and transmembrane domain (TM). (B) SDSpolyacrylamide gel electrophoresis analysis of the SARS-CoV-2 S protein (indicated by the arrowhead) expressed in human embryonic kidney (HEK) 293F cells. Lane 1: filtered supernatant from transfected cells; lane 2: flow-through from StrepTactin resin; lane 3: wash from StrepTactin resin; lane 4: elution from StrepTactin resin. (C) Negative-stain EM 2D class averages of the SARS-CoV-2 S protein. 2D class averages of the SARS-CoV-2 S protein are shown, confirming that the protein adopts the trimeric prefusion conformation matching the material used to determine the structure (4).

To determine the site-specific glycosylation of SARS-CoV-2 S, we used trypsin, chymotrypsin, and -lytic protease to generate three glycopeptide samples. These proteases were selected to generate glycopeptides that contain a single N-linked glycan sequon. The glycopeptides were analyzed by liquid chromatographymass spectrometry, and the glycan compositions were determined for all 22 N-linked glycan sites (Fig. 2). To convey the main processing features at each site, the abundances of each glycan are summed into oligomannose-type, hybrid-type, and categories of complex-type glycosylation based on branching and fucosylation. The detailed, expanded graphs showing the diverse range of glycan compositions are presented in table S1 and fig. S2.

The schematic illustrates the color code for the principal glycan types that can arise along the maturation pathway from oligomannose- to hybrid- to complex-type glycans. The graphs summarize quantitative mass spectrometric analysis of the glycan population present at individual N-linked glycosylation sites simplified into categories of glycans. The oligomannose-type glycan series (M9 to M5; Man9GlcNAc2 to Man5GlcNAc2) is colored green, afucosylated and fucosylated hybrid-type glycans (hybrid and F hybrid) are dashed pink, and complex glycans are grouped according to the number of antennae and presence of core fucosylation (A1 to FA4) and are colored pink. Unoccupancy of an N-linked glycan site is represented in gray. The pie charts summarize the quantification of these glycans. Glycan sites are colored according to oligomannose-type glycan content, with the glycan sites labeled in green (80 to 100%), orange (30 to 79%), and pink (0 to 29%). An extended version of the site-specific analysis showing the heterogeneity within each category can be found in table S1 and fig. S2. The bar graphs represent the mean quantities of three biological replicates, with error bars representing the standard error of the mean.

Two sites on SARS-CoV-2 S are principally oligomannose-type: N234 and N709. The predominant oligomannose-type glycan structure observed across the protein, with the exception of N234, is Man5GlcNAc2 (Man, mannose; GlcNAc, N-acetylglucosamine), which demonstrates that these sites are largely accessible to -1,2-mannosidases but are poor substrates for GlcNAcT-I, which is the gateway enzyme in the formation of hybrid- and complex-type glycans in the Golgi apparatus. The stage at which processing is impeded is a signature related to the density and presentation of glycans on the viral spike. For example, the more densely glycosylated spikes of HIV-1 Env and Lassa virus (LASV) GPC exhibit numerous sites dominated by Man9GlcNAc2 (2124).

A mixture of oligomannose- and complex-type glycans can be found at sites N61, N122, N603, N717, N801, and N1074 (Fig. 2). Of the 22 sites on the S protein, 8 contain substantial populations of oligomannose-type glycans, highlighting how the processing of the SARS-CoV-2 S glycans is divergent from host glycoproteins (25). The remaining 14 sites are dominated by processed, complex-type glycans.

Although unoccupied glycosylation sites were detected on SARS-CoV-2 S, when quantified they were revealed to form a very minor component of the total peptide pool (table S2). In HIV-1 immunogen research, the holes generated by unoccupied glycan sites have been shown to be immunogenic and potentially give rise to distracting epitopes (26). The high occupancy of N-linked glycan sequons of SARS-CoV-2 S indicates that recombinant immunogens will not require further optimization to enhance site occupancy.

Using the cryo-EM structure of the trimeric SARS-CoV-2 S protein [Protein Data Bank (PDB) ID 6VSB] (4), we mapped the glycosylation status of the coronavirus spike mimetic onto the experimentally determined three-dimensional (3D) structure (Fig. 3). This combined mass spectrometric and cryo-EM analysis reveals how the N-linked glycans occlude distinct regions across the surface of the SARS-CoV-2 spike.

Representative glycans are modeled onto the prefusion structure of the trimeric SARS-CoV-2 S glycoprotein (PDB ID 6VSB) (4), with one RBD in the up conformation and the other two RBDs in the down conformation. The glycans are colored according to oligomannose content as defined by the key. ACE2 receptor binding sites are highlighted in light blue. The S1 and S2 subunits are rendered with translucent surface representation, colored light and dark gray, respectively. The flexible loops on which the N74 and N149 glycan sites reside are represented as gray dashed lines, with glycan sites on the loops mapped at their approximate regions.

Shielding of the receptor binding sites on the SARS-CoV-2 spike by proximal glycosylation sites (N165, N234, N343) can be observed, especially when the receptor binding domain is in the down conformation. The shielding of receptor binding sites by glycans is a common feature of viral glycoproteins, as observed on SARS-CoV-1 S (10, 13), HIV-1 Env (27), influenza hemagglutinin (28, 29), and LASV GPC (24). Given the functional constraints of receptor binding sites and the resulting low mutation rates of these residues, there is likely selective pressure to use N-linked glycans to camouflage one of the most conserved and potentially vulnerable areas of their respective glycoproteins (30, 31).

We note the dispersion of oligomannose-type glycans across both the S1 and S2 subunits. This is in contrast to other viral glycoproteins; for example, the dense glycan clusters in several strains of HIV-1 Env induce oligomannose-type glycans that are recognized by antibodies (32, 33). In SARS-CoV-2 S, the oligomannose-type structures are likely protected by the protein component, as exemplified by the N234 glycan, which is partially sandwiched between the N-terminal and receptor binding domains (Fig. 3).

We characterized the N-linked glycans on extended flexible loop structures (N74 and N149) and at the membrane-proximal C terminus (N1158, N1173, N1194) that were not resolved in the cryo-EM maps (4). These were determined to be complex-type glycans, consistent with steric accessibility of these residues.

Whereas the oligomannose-type glycan content (28%) (table S2) is above that observed on typical host glycoproteins, it is lower than other viral glycoproteins. For example, one of the most densely glycosylated viral spike proteins is HIV-1 Env, which exhibits ~60% oligomannose-type glycans (21, 34). This suggests that the SARS-CoV-2 S protein is less densely glycosylated and that the glycans form less of a shield compared with other viral glycoproteins, including HIV-1 Env and LASV GPC, which may be beneficial for the elicitation of neutralizing antibodies.

Additionally, the processing of complex-type glycans is an important consideration in immunogen engineering, especially considering that epitopes of neutralizing antibodies against SARS-CoV-2 S can contain fucosylated glycans at N343 (35). Across the 22 N-linked glycosylation sites, 52% are fucosylated and 15% of the glycans contain at least one sialic acid residue (table S2 and fig. S3). Our analysis reveals that N343 is highly fucosylated with 98% of detected glycans bearing fucose residues. Glycan modifications can be heavily influenced by the cellular expression system used. We have previously demonstrated for HIV-1 Env glycosylation that the processing of complex-type glycans is driven by the producer cell but that the levels of oligomannose-type glycans were largely independent of the expression system and are much more closely related to the protein structure and glycan density (36).

Highly dense glycan shields, such as those observed on LASV GPC and HIV-1 Env, feature so-called mannose clusters (22, 24) on the protein surface (Fig. 4). Whereas small mannose-type clusters have been characterized on the S1 subunit of Middle East respiratory syndrome (MERS)CoV S (10), no such phenomenon has been observed for the SARS-CoV-1 or SARS-CoV-2 S proteins. The site-specific glycosylation analysis reported here suggests that the glycan shield of SARS-CoV-2 S is consistent with other coronaviruses and similarly exhibits numerous vulnerabilities throughout the glycan shield (10). Last, we detected trace levels of O-linked glycosylation at Thr323/Ser325 (T323/S325), with over 99% of these sites unmodified (fig. S4), suggesting that O-linked glycosylation of this region is minimal when the structure is native-like.

From left to right, MERS-CoV S (10), SARS-CoV-1 S (10), SARS-CoV-2 S, LASV GPC (24), and HIV-1 Env (8, 21). Site-specific N-linked glycan oligomannose quantifications are colored according to the key. All glycoproteins were expressed as soluble trimers in HEK 293F cells apart from LASV GPC, which was derived from virus-like particles from Madin-Darby canine kidney II cells.

Our glycosylation analysis of SARS-CoV-2 offers a detailed benchmark of site-specific glycan signatures characteristic of a natively folded trimeric spike. As an increasing number of glycoprotein-based vaccine candidates are being developed, their detailed glycan analysis offers a route for comparing immunogen integrity and will also be important to monitor as manufacturing processes are scaled for clinical use. Glycan profiling will therefore also be an important measure of antigen quality in the manufacture of serological testing kits. Last, with the advent of nucleotide-based vaccines, it will be important to understand how those delivery mechanisms affect immunogen processing and presentation.

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Site-specific glycan analysis of the SARS-CoV-2 spike - Science Magazine