Medical school brings a virtual touch to anatomy studies | The ... Sacramento Bee Touchscreen tables replace cadavers that would be found in a traditional anatomy lab at University of Nevada Las Vegas's new School of Medicine. |
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Medical school brings a virtual touch to anatomy studies | The ... - Sacramento Bee
CHICAGO, Feb. 21, 2017 /PRNewswire/ -- In physics the search goes on to find the one unified theory of how all forces in the universe originate from a single field, a single unifying force. Einstein sought after the "theory of everything" until his death but never found it. What if there is a grand unified theory of how all disease begins? Dr. Keith Nemec, the director of Total Health Institute, an alternative and integrative medical facility in Chicago and a graduate of University of South Florida's Morsani College of Medicine, believes that this unifying cause of all disease is inflammation at the cellular level.
Dr. Nemec has begun his preparatory Ph.D. research in Metabolic and Nutritional Medicine focusing on the underlying cause of health and disease. According to Dr. Nemec, "All disease starts with cellular inflammation. Whether you have cancer, heart disease, diabetes, digestive disorders, autoimmune disease or Alzheimer's, it all starts with inflammation at the cellular level which leads to either early cell death translating into specific organ or gland disease or into cancer stem cell stimulation which fuels cancer cell growth and metastasis."
Dr. Nemec explains that disease cannot be resolved by looking at the disease and trying to cure it, but by looking at the environment that allows all disease to form and changing that instead. According to Dr. Nemec, "If you put garbage on your driveway it will attract flies. If you want to get rid of the flies how many cans of insecticide will you need? The answer is infinite because no matter how many flies you kill more will come because you have an environment (the garbage) that enables them to grow. When you change the environment (get rid of the garbage) the flies will be gone and so will the disease, all disease."
Dr. Nemec states, "All cells need four basic elements to live and thrive. Oxygen in, water in, food in and waste products out. If these are done on a timely basis the cells will live very long. The human body was designed by God to live well over a hundred years in health but this can only be achieved when these four elements are efficiently maintained. If there is a breakdown of any of these four at the cellular level, this is when inflammation, the precursor to all disease, begins."
Dr. Nemec's vision is catching on as people are traveling from around the globe to Total Health Institute to change their cellular environment with the Institute's treatment and teaching programs.
Dr. Nemec is an author, and lecturer in the field of diet and nutritional medicine. Dr. Nemec is a board-certified diplomate of American Board of Anti-Aging Health Practitioners. This is a certification program of the American Academy of Anti-Aging Medicine. Dr. Keith Nemec also holds his fellowship in Integrative Cancer Therapy through American Academy of Anti-Aging Medicine.
Dr. Nemec can be contacted through the Total Health Institute's website totalhealthinstitute.com.
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Leading Integrative Medicine Institute Reveals the Single Unifying Cause of All Disease - Yahoo Finance
February 20, 2017 Credit: CC0 Public Domain
Gene editing techniques developed in the last five years could help in the battle against cancer and inherited diseases, a University of Exeter scientist says.
Dr Edze Westra said the ability to splice selected DNA into cells with great precision would become "super important" in the next two decades. There could be benefits for generations of people affected by cancer, failing vision and the diseases of old age or bad genes.
"There is always a risk with this kind of technology and fears about designer babies and we have started having discussions about that so we can understand the consequences and long-term risks," said Dr Westra, of the Environment and Sustainability Institute on the University of Exeter's Penryn Campus in Cornwall. "I think in the coming decades gene editing will become super important, and I think we will see it being used to cure some inherited diseases, to cure cancers, to restore sight to people by transplanting genes. I think it will definitely have massive importance."
On Tuesday, two highly influential academic bodies in the US shook up the scientific world with a report that, for the first time, acknowledged the medical potential of editing inherited genes. The National Academy of Sciences and National Academy of Medicine ruled that gene editing of the human "germline"eggs, sperm and embryosshould not be seen as a red line in medical research.
Many critics insist that powerful new gene editing techniques should never be used to alter inherited DNA. They argue that such a move would be the start of a slippery slope leading to "designer" babies with selected features such as blue eyes, high intelligence or sporting prowess.
But the two pillars of the American scientific establishment said that with necessary safeguards, future use of germline gene editing to treat or prevent disease and disability was a "realistic possibility that deserves serious consideration".
Dr Westra is taking part in a discussion on gene editing and its potential implications for society at the American Association for the Advancement of Science (AAAS) annual meeting in Boston, Massachusetts. He said gene editing technology not only held out the promise of fixing genetic faults, but could be used to turn cells into miniature factories that churned out therapeutic chemicals or antibodies.
One application was the use of "gene drives" that increase the prevalence of a certain trait in a population. For instance, gene editing machinery placed inside the cells of large numbers of malaria transmitting mosquitoes could prevent them spreading the organism that causes the disease to humans.
The most promising form of gene editing, known as CRISPR/Cas9, was first demonstrated in 2012. It employs a defence system bacteria use to protect themselves against viruses. A carefully targeted enzyme is used as chemical "scissors" that cut through specific sections of double stranded DNA. Then the cell's own DNA repair machinery can be exploited to insert the "pasted" genetic material.
Dr Westra said: "Gene editing is causing a true revolution in science and medicine because it allows for very precise DNA surgery. "A mutation in a gene that causes disease can now be repaired using CRISPR."
Explore further: No designer babies, but gene editing to avoid disease? Maybe
A research team from the United States and Canada has developed and successfully tested new computational software that determines whether a human DNA sample includes an epigenetic add-on linked to cancer and other adverse ...
Gene discovery research is uncovering new information about similarities and differences underlying various neurodevelopmental disorders.
A University of Toronto (U of T) study on fruit flies has uncovered a gene that could play a key role in obesity in humans.
Our genes play a significant role in how anxious we feel when faced with spatial and mathematical tasks, such as reading a map or solving a geometry problem, according to a new study by researchers from King's College London.
Gene editing techniques developed in the last five years could help in the battle against cancer and inherited diseases, a University of Exeter scientist says.
(Medical Xpress)A team of researchers with New England Biolabs Inc. (NEB) has found that sequenced DNA samples held in public databases had higher than expected low-frequency mutation error rates. In their paper published ...
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Gene editing could help tackle cancer and inherited diseases - Medical Xpress
Zaza Pachulia holds his own during competitive games of poker on the airplane alongside Stephen Curry and Klay Thompson they call it the "Good Guys Table." Andre Iguodala and JaVale McGee, one-time teammates with Denver reunited in Oakland, hold secret chats.
"We're building an empire," Iguodala joked. "We've got secret stuff we can't talk about."
Jonnie West son of Hall of Famer and Warriors executive Jerry West joins Curry, Pachulia and Thompson for their card games.
"It depends how Klay feels. If he's tired, then no card game," Pachulia said.
With all that was made before the season about adding Kevin Durant to an already star-studded roster, Golden State's players have jelled just fine. The NBA-best Warriors (47-9) are gearing up for the second half and what they hope is another championship run, and chemistry sure isn't holding them back.
Two-time reigning MVP Curry and KD love to watch each other accomplish amazing things on the floor, along with Draymond Green and Thompson and all of the others who contribute off the bench.
Curry initially allowed Durant to find his groove, then began to assert himself more and increase his shots. Experience playing together is the biggest factor to keep building team bonds, if you ask Iguodala.
"Weathering storms builds chemistry and adversity builds chemistry," he said. "The season's long and you want to have all types of ups and downs. And that's where you build it the most, and off the court, plane rides. I think when you play with teammates seven, eight years, you're still building throughout that time. You continue to learn about each other. You've just got to understand that that's part of the process and you've got to want to learn from one another."
The Warriors are counting on every advantage they can gain, on and off the court. During flights, team dinners, anywhere.
After a heartbreaking Game 7 to end last season's NBA Finals, Golden State's players want nothing short of a championship. Many of them got a taste winning the title two years ago for the franchise's first in 40 years.
Steve Kerr, the reigning NBA Coach of the Year, gets a kick out of watching his teams come together each year.
"It's one of my favorite parts of coaching honestly, is seeing how a team comes together, seeing the relationships develop, seeing guys laughing together, seeing who hangs out with who," Kerr said. "It's great. This team has a really, really good chemistry that developed really quickly. Obviously, we had the core group intact from last year. We lost some key guys, too. The additions have been great. The chemistry is really good."
Pachulia took it upon himself to be a part of that. With constant attention on the Warriors, he knows the importance of sticking together through all of the many challenges that come in an 82-game season and those things prepare a group for the postseason.
"You wish for the chemistry to come right away because you're kind of feeling pressure, a lot of talk's going on from outside," Pachulia said. "The reality is it's a process. It takes some days, it takes some games. It takes some bumps as well for the team to get on the same page and get the chemistry right. You've got to go through the process. I just don't see it the other way. We couldn't wait for these 40 or 50 games to pass and see where we were going to be. I feel really confident where we are right now, with everything we had throughout this 50 games, even the losses we had unexpected. It made us better, it made us stronger. You can appreciate it, honestly. We care about each other. We're on the same page. Keep going. We're not going to stop."
For Iguodala and McGee, the "chatter" stays between them.
"I have a lot of really in-depth conversations with JaVale McGee," Iguodala said, "about life."
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Power of science: Warriors thrive with chemistry experiment - Chicago Tribune
The unexpected supramolecular chemistry of nitrate anions ... Science Daily A team of researchers argues that the nitrate anion can display a counterintuitive Lewis acidity. Their findings may serve as a (retrospective) guide to interpret ... |
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Shaka Hislop evaluates Pep Guardiola's interest in Jack Wilshere, and whether he would fit in at Manchester City.
Right now, Bournemouth are in what full-back Charlie Daniels describes as a "hard time."The club are struggling for results, the squad available to Eddie Howe is the weakest one they have had all season and it even looks like their once-strong home form is also fading.
Bournemouth have not won since Dec. 31 and the forecast for future points remains bleak considering their recent performances. Latest defeats to some very mediocre sides such as Crystal Palace, Hull and Millwall hint that victory against West Brom is a bigger ask than it arguably should be. The Baggies are flying at the moment in eighth position and are unbeaten in their last four, so the Cherries have a tough game on their hands.
"One win and the confidence will come back" said Josh King, before further suggesting success on the south coast is a habit. He's right, and as seen last season with the late equaliser against Everton, a small but significant moment can easily propel the side into a run of good form. Bournemouth are a team that thrive on confidence and team chemistry. They don't rely on star names to dig them out of trouble nor do they have an arrogance about their play. They are mentally frail because of this, but when the Cherries are playing with acquired authority and confidence they are a match for any side. They will be in the hunt for that season-changing moment against the Baggies as well as a pressure-releasing win.
Positive mindsets are the main thing that the players will need to take into the clash on Feb. 25 and Howe simply needs to play to his team's strengths. One thing the manager can rely on is the work rate in central midfield. Howe's preference to start Andrew Surman is costing the team and he needs to be dropped for the more energetic Dan Gosling. The former suits his style of free-flowing expansive football, but right now Bournemouth need security and the extra never-say-die attitude from Gosling's play should be added to Harry Arter's similar style.
Daniels and Adam Smith are full of questions defensively but in terms of attacking output they are a class above the rest. They are the biggest offensive threat at the moment and playing both of them is essential in the quest of goals. Bournemouth need a defensive overhaul in the summer, but right now they are stuck with what they have got so using both the full-backs to their main strengths is a must.
Jordon Ibe's influence of late is something that needs to be seized upon as well. His performance against Manchester City on Feb. 13 was decent and he was unfazed by the household names on Pep Guardiola's team sheet. The lack of fear displayed by Ibe is another part of Bournemouth's play which needs to be utilised.
Problem areas remain in the centre of defence and the possibility of a free transfer from somewhere seriously needs to be considered as Simon Francis is just not Premier League level. Christian Samba is available and at just 32 years old he is seemingly not completely past it yet. His experience all over Europe and at international level would be useful.
Benik Afobe supplies some competition up front to Josh King and his physicality off the bench is a good option to have late on in attempts to wear down an already tired back four. Jonny Evans is likely to start in the Baggies back four and he isn't the quickest defender in the league so King's pace should be preferred.
A team break in Spain --despite the mix up with the anti-doping charge--with a change of scenery and escape from Bournemouth should help the squad. Everything is in favour of the Cherries picking up points, but as we have seen previously this season, they are not the best side away from home. Bournemouth were 9-1 to get relegated at the end of January, and odds have since dropped to 7-1. Another defeat to West Brom and these odds will drop further and fans should definitely start to fear relegation. The season is currently on a tightrope.
Will Kent is a freelance journalist who has worked for AFC Bournemouth, ESPN UK and ESPN FC, among others. Twitter: @WillKentSPORT
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With the NBA trade deadline in the rear view mirror, the Celtics will have to turn to the buyout market if they are looking to make changes to their roster.
Talking to CSN Celtics InsiderA. Sherrod Blakely, Danny Ainge explained why signing players who have been bought out can be a risky move for a team like the Celtics.
Well weigh each guy that comes on the market and see if that can be a boost to our team, explained Ainge. At the same time, I like our team. Bringing in new players sometimes messes up your whole chemistry, and it shifts somebody into a different role that theyre not accustomed to doing. You better know what youre getting.
We brought in Michael Finley, Sam Cassell. . . PJ Brown turned out to be a very good asset to us. Most of the time it sort of disrupts things. At the end of the year you go, wow, we probably shouldnt have done that. Even though on paper it looked like a great acquisition, it wasnt as good as everyone thought it would be.
Chris Mannix breaks down the Boston Celtics deciding to stand pat at the trade deadline, and how the C's were not very close at all to getting Paul George.
For the second straight season the trade deadline came and went with no moves from the Boston Celtics.
President of basketball operations Danny Ainge continues to look at the big picture as his team moves forward with their roster intact.
It wasnt for lack of trying, last year and this year, said Ainge. We came away with Al Horford in the summer. We drafted Jaylen Brown, Jaylen just continually getting better. Im very excited about the future of both those guys. We were also able to get Ante Zizic, who is having a terrific year over in Turkey. I think that our future is looking good.
We hope to have another good summer this year, whether we use the draft pick, whether we trade the draft pick. I think we cant go wrong, as long as we dont screw it up and pay too much for certain assets.
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Ainge: Adding players 'sometimes messes up your chemistry' - Comcast SportsNet New England
WASHINGTON, Feb. 23, 2017 Iowa Gov. Terry Branstad, President Trumps choice to be the next U.S. ambassador to China, said today that if confirmed he will make it a priority to get China to lift its ban on U.S. beef and reform its biotechnology approval process.
Branstad spoke at USDAs annual Agricultural Outlook Forum before a scheduled meeting at the Chinese embassy in Washington,
We soon hope to reopen the market for American beef, Branstad said. I want to serve it at the (U.S.) embassy and I certainly want to do what I can to convince the Chinese leadership to do that sooner than later.
It was in September last year that China announced it was going to lift its 14-year-old ban on U.S. beef, but there have been no signs since then that the country was actually following through with that promise.
China was just one of many countries that banned U.S. beef in 2003 after theU.S. discovered its first case of bovine spongiform encephalopathy (BSE).Since then most countries have lifted those bans, and in 2013 the World Organization for Animal Health (OIE) announced that it was placing the U.S. into the negligible, or lowest risk category, for BSE, commonly known as mad cow disease.. Previously the U.S. fell into the higher controlled risk category.
Mad cow disease is long since gone in this country, Branstad said. Theres no reason why the Chinese should continue to restrict American beef. Thats one of the things high on my priority list.
Another thing high on his priority list is persuading China to reform its biotechnology approval process. The Obama administration tried for years to get China to begin the approval process of new seed traits at the same time as regulators in the U.S. or other countries begin. But little progress has been made.
China, to the growing frustration of U.S. farm groups and biotech seed companies, continues to refuse to begin its approval process until new traits have already been approved in another country first. That can add years to the time that it takes for seed companies to get their products on the market.
Furthermore, Branstad said another priority wouldbe to persuadethe Chinese to remove stiff import duties on U.S. distillers dried grains with solubles (DDGS).
It was just last month that Chinas Commerce Ministry slapped new duties and taxes on DDGS that total roughly 90 percent of the price of the commodity, a byproduct of ethanol production and a popular livestock feed ingredient.
U.S. Grains Council President Tom Sleight says the barriers are high enough to virtually halt U.S. exports to China.
China bought 6.3 million tons of DDGS in 2015, valued at about $1.6 billion, according to U.S. Grains Council officials. That was up from 4.3 million tons, valued at $1.25 billion,in 2014.
Branstad told Agri-Pulse that he expects to succeed where others have failed in China because of his strong personal relationships with Chinese President Xi Jinping and other high-ranking officials.
I have the advantage of being an old friend of President Xi, he said.His very first trip to America was to Iowa. He led a corn processing delegation that came to Iowa in 1985.
The two have stayed in contact since then, Branstad said. We have a longstanding personal relationship and thats really important in their culture. I think thats why President Trump chose me.
Branstad also stressed today that the U.S. and China are already major trading partners and he hopes to expand that relationship.
IncreasingChinas demand for U.S. farm commodities took up a significant part of USDA Chief Economist Robert Johansson's presentation today at the Outlook Forum.
Are you tracking trade issues? Follow Agri-Pulse for more in-depth coverage. Sign up for a four-week free trial now.
China is the largest destination for U.S. agricultural exports and the country's demand continues togrow for American soybeans, cotton, wheat and other commodities, Johansson said.
In (fiscal year) 2017 U.S. exports to China are projected at $22.3 billion, up more than $3 billion from 2016 and making it the top export market for U.S. agriculture, Johansson said.
The future is especially bright for Chinese imports of soybeans and cotton, he said, predictingthat China will be buying about 14 million bales of cotton from the U.S. annually 10years from now, a 9.6-million-bale increase from present sales.
I look forward to being an advocate for all agricultural exports in this new role. Im humbled by the prospect that a farm kid from Iowa could be chosen to represent our country in China.
#30
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Trade Talk. Cap Gymnastics. A Surprise Phone Call. A Short-Handed Scrimmage. It's All Part Of 'The Anatomy Of A Day In The Mavs' Trade-Deadline Life.'
The first soon-to-be-public domino topples innocuously enough, with Dallas Mavericks rookie center AJ Hammons showing up for work in Frisco, expecting to be a starter for Wednesday nights D-League game between the Mavs affiliate the Texas Legends vs. the LA D-Fenders.
At 3:36, I receive a text.
Hammons is being recalled by the Mavs today.
And right about at this time, Legends coach Bob MacKinnon contacts Hammons.
Youre going downtown, MacKinnon tells the kid.
I ask a Mavs staffer if Hammons hurry-up drive south down the Tollway (a move made official at 3:49) had anything to do with the possibility of a trade-deadline-centered Dallas roster shuffle.
You could surmise that, yes, he tells me.
And then comes a Mavs practice. (It is suggested to me that the workout is largely a scrimmage, and that coach Rick Carlisle will supervise another scrimmage on Thursday as the team comes back from its All-Star Break and preps for a Friday game at Minnesota and a Saturday AAC meeting with Boogie Cousins Pelicans). And it is a Mavs practice that does not feature Andrew Bogut or Deron Williams.
We were just told a trade might happen, J.J. Barea reveals to the media collected downtown. So theyre not here.
Both sit out, protectively bubble-wrapped in order to be safely delivered to their new teams by the 2 p.m. Thursday deadline if the Mavs can procure from suitors just the right future-value bounty.
Says Carlisle: If it turns out they're not here, they're not here and this is what we got. And if there are trades, there's a chance there's going to be some players coming back that could help us. But we'll see. We'll know by 2 o'clock tomorrow, and we'll go from there.
That players coming back part is a significant revelation to those of you whove been following how a D-Will-to-Cleveland trade might have to work. More on that below
Assorted other vignettes, takes and dominos as part ofThe Anatomy Of A Day In The Mavs Trade-Deadline Life:
*Just 24 hours earlier, Dallas discusses with Utah the idea of trading Williams to the Jazz. Its not an unappealing idea to D-Will (who once played in Utah and owns a home there and would seemingly waive his trade-veto rights to return). Im told Utah is not enthralled with the idea of sacrificing whatever first-rounder (the Jazz have a cache of them) Dallas is asking for. But at least the conversations are on and inside the Mavs headquarters on Wednesday morning, the idea remains a topic of discussion.
*The same is true of the concept of a Bogut trade to Boston(details here), though a source continues to tell me that a bigger shoe needs to drop first for the Celtics before they turn to the idea of giving up a 2018-or-later pick for the center.
*Mavs GM Donnie Nelson is the point man on many of the conversations, including the in-house ones in which the staff discusses ideas to pursue the likes of Utahs Derrick Favors and Detroits Andre Drummond. Assistant Michael Finley is a key voice in the room.
*At some point after 10:37 a.m., the D-Will-to-Utah talks are supplemented by D-Will-to-Cleveland talks. This is happy news inside Dallas HQ; the Mavs believe this is the Cavs long-sought-after target. Maybe theyre right but in the early afternoon Im told Cleveland is also willing to ask Mario Chalmers to come off the couch to serve as the off-the-bench playmaker LeBron James desires.
*The ideal Deron trade brings back nothing but picks; theres no desire to let a Channing Frye or a Man Shumpert clog the Mavs summer salary cap. So there are complicated ways to pull that off. A three-way involving another team, and letting the Cavs player go somewhere other than Dallas. A complicated swap with the Cavs that involves not only Deron but Bogut, too. All these are considered by Mark Cuban and staff keeping in mind that because of Utahs cap situation (as compared to Clevelands) a D-Will trade to the Jazz requires no filler, no matching, no cap gymnastics.(See David Lord's incomparable insight into these "deeply involved'' trade talks here.)
*Take this as either a) a sign that Deron and/or Bogut deal(s) are going down or b) that the Mavs are really, really doing their just-in-case preparatory homework. But consider the Mavs roster post-trade. If Carlisles forecast is right and Dallas gets some players coming back, this isnt an issue.
Or
Two players go out and fewer than two players come back. Its so feasible that the Mavs staff decides it had better assemble a list of D-League prospects, a list of guys on the couch, a list of prospects playing in China who will soon be eligible to sign NBA deals.
How real am I being about this concept? Im giving you names. If the Mavs have roster vacancies, they will consider quickly sending out weekend feelers to D-Leaguer Jalen Jones (of Maine and formerly of Texas A&M), to Manny Harris and Pierre Jackson (of the Legends), to Ray McCallum (now on his second 10-day with the Hornets), to Briante Weber (the D-League star now on a 10-day with Golden State), maybe to the aforementioned Chalmers, and eventually, when his China service is done, to J.J. Hickson, the former Wizards big man.
*The organization is still struggling to wrap its collective head around the ideas of being non-competitive, of tanking, of organic tanking. Somebody on the staff mentions out-loud how Boogie and The Brow are almost certain to lead New Orleans to a charge for the No. 8 spot in the West playoffs, leaving Dallas in the lottery dust.
I dont know what Carlisles private reply to that is. I know his public answer.
Were in a dynamic business, he says to the Wednesday afternoon media. Theres plenty going on.
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Anatomy Of A Day In The Mavs' Trade-Deadline Life - Scout
EW.com | 'Grey's Anatomy' recap: 'Back Where You Belong' EW.com The band is back together again! Not quite, Maggie, but you've got the right idea. Amelia, who's back at Casa de Meredith for who knows how long, insists that she's not back, she's just sleeping there (a.k.a. she's still just hiding from Owen). But ... How Well Do Grey's Anatomy's Ellen Pompeo & Justin Chambers Really Know Each Other? Grey's Anatomy: Minnick and Arizona Share a Secret Why 'Grey's Anatomy' remains compelling TV, and 'Scandal' isn't |
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'Grey's Anatomy' recap: 'Back Where You Belong' - EW.com
Shondaland leading ladies Kerry Washington and Ellen Pompeo welcome The Catchstar Mireille Enos to ABCs TGIT lineup in a new popcorn and wine-filled promo.
Walking down the street, donning a black trench coat, Enos says, Hope I havent kept you waiting, as she slips into silky pajamas.
Welcome to the party, Washington says to Enos, pouring Olivia Popes drink of choice: red wine.
ABC
The Scandal star and Greys Anatomys Meredith Grey then toast Alice Vaughan making her way to the Shonda Rhimes-created ABC Thursday night schedule. Absent from the group is How To Get Away With Murders Viola Davis as Annalise Keating, who was previously included in anotherpromo with Washington and Pompeo.
Season 2 of The Catch is replacing HTGAWM after its Season 3 two-hour finale airs tonight. Earlier this month, ABC gave early renewals to all its TGIT drama lineup.Greyswas picked up for a 14th season, Scandalfor a seventh and HTGAWM for afourth season.
Season 2 of The Catch premieres Thursday, March 9 at 10 PM on ABC.
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'Scandal' & 'Grey's Anatomy' Leading Ladies Welcome 'Catch' Star To TGIT In New Shondaland Promo - Deadline
Hugh Jackman and James Mangolds Logan is about to make its debut in theaters, and with early reviews in, this sounds like the Wolverine stand-alone movie fans have been clamouring for. Wolverine is a beloved comic book character and has been taken to new heights with Jackmans performances spanning multiple X-Men and stand-alone movies.
But hes also an anti-hero, which makes his rise to fame that much more interesting. What is it about Wolverine, and anti-heroes in general, that make them so endearing? Investigating this question, there are specific qualities anti-heroes have that not only make them anti-heroes but also warms them up to the hearts of fans the world over.
Heres a look at the anatomy of an anti-hero as found in comic books, movies and television shows.
Most anti-heroes begin their heros journey on the peripheries of society. Starting with Wolverine, he begins Bryan Singers X-Men movie making a living fighting inside a steel cage in a seedy Alberta bar. Its only until he meets Rouge that he leaves that life as an outcast and moves toward a life a part of the collective, or in Logans case, as a card carrying member of the X-Men.
Keeping with films featuring Marvel Comics characters, virtually the entire main cast of James Gunns Guardians of the Galaxy are outcasts. Peter Quill, Starlord to his close friends, begins the film as a thief, stealing an ancient orb, one that lands a bounty on Quills head. Ensuing, Rocket Raccoon and Groot, two bounty hunters try capturing Quill, only to be thwarted by Gamora. The entire band of misfits are eventually arrested and sent to prison, where they run into their final member of the Guardians of the Galaxy, Drax. All five members of the Guardians of the Galaxy are outsiders, all living above or beneath the law, and all eventually being put behind bars until they band together to break out.
Stepping away from comics, Mad Max in George Millers The Road Warrior begins the movie as a lonely drifter, completely cut off from society. His life consists of scavenging old vehicles for a few litres of gas, and eating dog food from rusty cans. The successive movies, Mad Max: Beyond Thunderdome and the recent masterpiece Max Mad: Fury Road, find Max still roaming out in the wastelands, an outsider looking into a post-apocalyptic society.
Women are not immune to the outsider status either. In Netflixs Jessica Jones, our favourite leather jacket wearing anti-hero works as a private investigator, working outside the law. Her fledgling P.I. company, questionable business practices and foul mouth keep her on the periphery of New York society, never fully able to be a part of what society would deem successful.
The reluctant nature of many anti-heroes is another common quality. In The Road Warrior, Max wants nothing to do with the resistance fighting against the goalie mask wearing Humungous. He only wants gasoline for his car, and the bare essentials of survival. As events unfold, Max is reluctantly pulled into the fray, but its not out of the kindness of his heart.
Everyones favourite space smuggler in a galaxy far, far away falls into this category as well. When we first meet Han Solo in A New Hope, he is hired by Obi-Wan Kenobi for passage to Alderaan. After coming out of light speed, there is no Alderaan and the Millennium Falcon is tractor-beamed into the Death Star. When Solo finds out Princess Leia is also aboard, he wants nothing to do with her rescue. Its only through dollar signs that he decides to help. Nearing the films climax, Han leaves with his loot, not wanting anything to do with the Rebels attack on the Death Star. But fear not, reluctance only lasts so long with anti-heroes Han plays a major last second hand in giving Luke enough space to destroy the Death Star.
For many anti-heroes, there is a side to him or her that no one wants to be on. That side is vengeance. In George Millers first introduction to Max in Mad Max, he wasnt the drifter we know of him today. He is a loving family man. A police officer whose wife and child are run down by an Australian motorcycle gang. This pushes Max over the edge, and leads not only to Max turning to vengeance in that film, but in the film following. In The Road Warrior, Maxs dog is killed by Humongous gang this loss of family is once again the thing that pushes Max to murder and mayhem.
Running with the dog theme, Keanu Reeves in John Wick, turns into a vengeful killer, one that would make Charles Bronson jealous. Wicks car gets stolen and his dog is killed. The result is a vengeful body count done so well, a second instalment was made and is presently in theatres.
The Punishers entire existence is built on vengeance. First appearing in The Amazing Spiderman #129, the Punisher was a vigilante who readers fell head over heels for. Through the comic years, it was revealed that Frank Castles family were all murdered by the mob. As a result, this war veteran enacts his own brand brutal and systemic justice on New Yorks worst.
In last years smash hit film Deadpool, Wade Wilsons entire film existence is built upon vengeance when he is mutated and modified to have superhuman regenerative capabilities. Deadpool goes after the mastermind of his altered state and becomes one of the most beloved anti-heroes ever on screen through vulgarity, violence and of course, vengeance.
And we couldnt have a vengeance category without writing about V from V for Vendetta. Much like Deadpool, V was created by a bad experiment gone horribly wrong. The Guy Fawkes mask wearing V makes it his lifes mission to avenge what happened to him and put the power back in the hands of the British people by eliminating evil doers in government.
This is where audiences get to fully enjoy the dark nature of the anti-hero. One of Han Solos most loveable qualities is his irritability. Whether its a way of masking sexual tension between himself and Princess Leia, or his general disdain for droids (one distinct golden rod comes to mind), Han is at his best with his sarcastic and irritable sensibility.
Guardians of the Galaxy member Rocket Raccoon is beloved for more than being a furry, talking animal. His prickly personality makes him that more loveable. Hes irritable and doesnt suffer fools gladly. Hes constantly at-wits-end with Groot, and takes great joy in the misfortune of others. There is something endearing about an irritable anti-hero.
For the anti-hero to be redeemable in an audiences eyes, he or she must have something deeper they must have a heart of gold. When the chips are down, they need to put others before their own selfish needs. A great example of this is Han Solo. Throughout the original Star Wars Trilogy, Han lets us into the size of his heart. He comes back to help Luke destroy the Death Star in Episode IV. He opens his heart up enough to fall for a certain princess. He sacrifices his own self-preservation by joining the Rebellion.
Throughout his time on screen, Wolverine has had perhaps the biggest heart of all. Hes been protective of Rouge, and eventually for all of Professor Xaviers students. He fell for Jean. To save his mutant brethren, he went back in time to right wrongs in Days of Future Past. Logan protects his heart with his anger and resentment, but that just makes him that more irresistible.
Much of the anti-heros motivations are done out of love. Sure there is vengeance and anger, but the anti-hero also wants to right wrong wrongs that have hurt his or her heart. Deadpool fights to save the woman he loves, V terrorizes the British government to show the people they dont have to live in fear, and all the Guardians of the Galaxy decide to band together and do something good, keeping the orb away from Ronan and saving the people of Xandar.
In all, the anti-hero is a complex individual. And these complexities have allowed many of them to have a place in popular culture and in fans hearts the world over.
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Logan, Han Solo and the Anatomy of an Anti-Hero - CGMagazine
Generex Biotechnology Corporation (OTCMKTS:GNBT) is a micro-cap biotech player that has been on the rise of late despite an avalanche of growing debt and no clear route to near term monetization. But such is the case quite often in this sector, even in the case of the best opportunities. GNBT stockis moving higher in recent days following a couple catalysts.
In the first case, the company announced a letter of intent for the acquisition of a controlling equity interest in Emmaus Life Sciences, Inc, a biopharmaceutical company engaged in the discovery, development, and commercialization of innovative treatments and therapies, primarily for rare and orphan disease. Initial product development efforts are focused on Sickle Cell Disease (SCD), a genetic disorder. In the second case, the company just announced that it has achieved the elimination of its outstanding derivative securities.
Generex Biotechnology Corporation (OTCMKTS:GNBT) trumpets itself as a company engaged in the research, development, and commercialization of drug delivery systems and technologies.
As the company states, Generex has developed a proprietary platform technology for the delivery of drugs into the human body through the oral cavity (with no deposit in the lungs). The Companys proprietary liquid formulations allow drugs typically administered by injection to be absorbed into the body by the lining of the inner mouth using the Companys proprietary RapidMist device. Antigen Express, Inc. is a wholly owned subsidiary of Generex.
The core platform technologies of Antigen Express comprise immunotherapeutic vaccines for the treatment of malignant, infectious, allergic, and autoimmune diseases. Antigen Express has pioneered the use of specific CD4+ T-helper stimulation technologies in immunotherapy. One focuses on modification of peptides with Ii-Key to increase potency, while a second relies on inhibition of expression of the Ii protein. Antigen Express scientists, and others, have shown clearly that suppression of expression of the Ii protein in cancer cells allows for potent stimulation of T-helper cells and prevents the further growth of cancer cells.
According to company materials, Hema Diagnostic Systems, LLC (www.rapid123.com) is a rapidly growing biotechnology company involved in the development, manufacture, assembly, and distribution of diagnostics targeting primary as well as orphan infectious diseases. Hema Diagnostic Systems continues to expand its product line to meet the needs of the worldwide market. Point-of-Care test devices are made simple to use and are highly cost effective when incorporated into Hema Diagnostic Systems patented and patent pending delivery systems. The Rapid 1-2-3 Hema EXPRESS is a novel delivery system that is self-contained and easy to use.
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In thinking about the potential benefits of a controlling position in Emmaus, Dr. Yutaka Niihara, MD, MPH, Chairman and CEO of Emmaus and Executive Chairman of Generex commented: R&D efforts continue apace at Emmaus, as evidenced by these new patents securing our intellectual property portfolio. We are pleased to add diverticulosis and diabetes as prospective new indications for our PGLG product which we are currently developing for the treatment of SCD.
Joseph Moscato, Generex President & CEO, stated: I am gratified by the confidence Emmaus has expressed in Generex in providing this leeway to allow us to consummate the reorganization of our capital structure which will set the stage for our future successes.
That said, our sense is that the biggest catalyst in recent action may actually be the cap table move through undercutting the companys derivative liabilities.
As noted in the companys most recent release, the consequent reduction in the number of shares coming into the market and the termination of the attendant price protection provisions will unburden the Company. In addition, the elimination of the derivative liability will greatly improve the Companys balance sheet. Thus unencumbered, and with a reinvigorated management team and Board of Directors, the Company will proceed to execute its business plans and to attract value investors.
The chart shows just under 290% piled on for shareholders of the listing during the trailing month. Market participants may want to pay attention to GNBTstock. Generex has a track record that includes a number of dramatic bounces. Whats more, the company has witnessed a pop in interest, as transaction volume levels have recently pushed just shy of 410% above its longer run average levels. Since we last covered the name, the stock has moved 58% higher.
Now commanding a market cap of $15.8M, GNBT has virtually no cash on the books, which compares with a mountain of current liabilities, in excess of $9 million. One should also note that debt has been growing over recent quarters. The company is pre-revenue at this point. This may be a very interesting story and we will look forward to updating it again soon. For continuing coverage on shares of GNBT stock, as well as our other hot stock picks, sign up for our free newsletter today and get our next hot stock pick!
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Generex Biotechnology Corporation (OTCMKTS:GNBT) Pushes Higher on New Catalysts - The Oracle Dispatch
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Cellect Biotechnology Ltd. (Nasdaq: APOP) announced today positive final results from its clinical trial of ApoGraft in healthy donors. The studys primary objective was to validate the Company's propriety method of stem cell selection by going through the process of production and characterization with ApoGraft, and was conducted on samples obtained in collaboration with two leading medical centers in Israel, The Schneider Children's Medical Center and the Rambam Medical Center.
Cellects technology enables the use of stem cells for regenerative therapies by eliminating mature cells while leaving the stem cells unharmed using a natural process occurring in the human body, apoptosis (programed cell death), which orders cells to commit suicide. Cellects validated scientific platform, and the focus of its 7 families of patents, is that the apoptosis command destroys primarily mature cells, while stem cells remain alive and flourishing. This process allows for natural enrichment of stem cells, thus enabling stem cell-based therapies or transplantation to possess an abundance of quality stem cells with little to no risk of rejection or other complications, such as Graft versus Host Disease (GvHD).
The study included 104 healthy donors of blood stem cells. The samples (collected under approval of Helsinki committees) represented 5% of a graft used for transplantation into patients. The grafts were processed allowing stem cell production for transplantation with Cellects ApoGraft. The use of the ApoGraft resulted in a significant increase in the death of mature immune cells, primarily T Lymphocytes, without compromising the quantity and quality of stem cells. The process takes only a few hours as compared to days of complex and expansive lab work with traditional methods, is anticipated to be extremely cost effective in comparison to current approaches, and has the potential to significantly reduce the risk of GvHD.
Dr. Yaron Pereg, Cellects Chief Development Officer, commented: These results from processing human stem cells for bone marrow transplantation using ApoGraft clearly demonstrated that Cellects proprietary platform could improve the outcome of stem cell transplantations in patients suffering from hematological malignancies.
Originally posted here:
Cellect Biotechnology (APOP) Announces Positive Results of Clinical Trial of ApoGraft - StreetInsider.com
Newswise Researchers in bioengineering at the University of Notre Dame will join a consortium of academia, industry and government organizations and the nonprofit sector to develop next-generation manufacturing processes and technologies for cells, tissues and organs.
The Advanced Regenerative Manufacturing Institute (ARMI), Manufacturing USA initiative, will bring together close to 100 partner organizations as part of continuing efforts to help revitalize American manufacturing and incentivize companies to invest in new technology development in the United States. Approximately $80 million from the Department of Defense will be combined with more than $200 million in cost share to support the development of tissue and organ manufacturing capabilities.
Scientists at Notre Dame will focus on the challenges of advanced tissue biofabrication, as well as making current technologies and solutions available to patients in need. As part of the consortium, the university joins 47 industrial partners, 26 academic and academically affiliated partners, and 14 government and nonprofit partners. The ARMI will focus on accelerating regenerative tissue research and creating state-of-the-art manufacturing innovations in biomaterial and cell processing for critical Department of Defense and civilian needs.
Notre Dame researchers and bioengineers already direct several federally funded research programs in regenerative medicine through the colleges of science and engineering and in conjunction with the Notre Dame Center for Stem Cells and Regenerative Medicine.
Were looking forward to collaborating with this group of industrial and academic partners, said Glen Niebur, professor of aerospace and mechanical engineering and director of the bioengineering graduate program at Notre Dame. Through our affiliation with ARMI, we have a great opportunity to contribute to making regenerative medicine products a reality.
The ARMI marks the third Manufacturing USA institute that the university has partnered with, including LIFT (Lightweight Innovations for Tomorrow) and the Digital Manufacturing & Design Innovation Institute.
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University of Notre Dame Partners with the Advanced Regenerative Manufacturing Institute - Newswise (press release)
Now Playing Grey's Anatomy Sneak Peek: Meredith Won't Be Bailey's "Yes Man"
How quickly will Meredith (Ellen Pompeo) return to Grey Sloan on Grey's Anatomy?
Bailey (Chandra Wilson) is ready for her chief of general surgery to come back to the hospital after serving a suspension, but as this exclusive clip from Thursday's episode shows, Meredith isn't so ready to consider everything that's happened water under the bridge.
With Eliza Minnick (Marika Dominczyk) and her new teaching methods causing dissent among the ranks of Grey Sloan staffers, Meredith is sticking to her guns and standing by Richard Webber (James Pickens Jr.). To put it bluntly, as Meredith tells Bailey, she's happy to be Bailey's right-hand woman, but isn't prepared to be her "yes man."
Check out the sneak peek to see how Bailey responds to Meredith's declaration. It looks like these two are going to continue to butt heads when Dr. Grey returns... or should we say if?
Grey's Anatomy airs Thursdays at 8/7c on ABC.
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Grey's Anatomy Exclusive: Meredith Refuses to Be Bailey's "Yes Man" - TV Guide (blog)
An older woman hesitantly shares her experiences of sexuality after recovering from cervical cancer. A lawyer-turned-prostitute intimately tells of her passion for other women. A young homeless woman recounts a memory of a traumatizing childhood rape. These are just a few of the many emotional and powerful monologues presented within playwright and activist Eve Enslers award-winning The Vagina Monologues.
The Vagina Monologues discusses the stigma around womens sexuality and spurs dialogue about women, violence against women and the push for equality. Through monologues compiled by Ensler, such as My Revolution Begins in the Body, My Short Skirt and My Vagina Was My Village, the play shares personal accounts of womens experiences and emotions on this topic. All proceeds from the play, presented by IC Players at two show times Feb. 19 in the Emerson Suites, benefited V-day, a global activist movement dedicated to increase awareness of violence against women. The performances drew in about 150 people for both shows and IC Players raised about $815 for the advocacy center.
After three years of acting in The Vagina Monologues, senior Jessica Braham, a theater arts management major at Ithaca College, directed the play. Braham said the play is especially relevant now because of the current political climate and that she strived to use her power to address these political issues.
I felt like I could bring my vision to life, and I could finally be the one to inspire other women to voice these stories, Braham said. Theres a lot of criticism about the show because people are asking, Why are we still doing this? Women have rights. But I felt like this year was the time. This is when we need it now more than ever.
Braham said a key theme in the play was to stress the importance of women supporting and empowering other women. She said that while directing the play, she especially encouraged the cast members to empower one another.
Women empowering other women is something that is so important and something that we dont really have a lot of, Braham said. This isnt the time to segregate ourselves and separate from the issues. This is when we all need to come together and rally and fight for what is right for our rights and equality.
True to the message of women supporting other women, sophomore Hannah Paquette, assistant director of the play, said she aimed to create a sense of community among the women whose stories they were telling in the play.
These dialogues and conversations and sometimes these thoughts dont even happen unless theres a community of women where those things can come out, Paquette said.
Another important part of the play, Paquette said, is that it changes each year. This year, the spotlight monologue, a piece written by Ensler and selectively added to the performance, was I Call You Body, a monologue demanding safe and violence-free workplaces. The spotlight monologues each year highlight specific issues that are stressed in the yearly campaign for One Billion Rising and Vday.org, two organizations established by Ensler to combat violence against women. The additions help keep The Vagina Monologues relevant, Paquette said, allowing for the play to be a living body of work.
Its a really important point of activism for me being able to do this show, especially in this time period, Paquette said. It [shows] defiance and resistance.
Erin Lockett, a freshman acting major and the narrator of the play, said the show is an important feminist piece because it addresses the stigma face-first, without any shyness.
I think that if not everyone, a lot of people are very uncomfortable talking about vaginas because of the stigma that surrounds it, she said. I think The Vagina Monologues brings up the stigma. It names it, and it addresses it, and it analyzes it.
Lockett said the play commands attention and respect because of its direct style of addressing touchy subjects.
I think thats just a way more powerful way to address [the stigma], she said.
Without powerful, artful statements such as this play, Braham said, none of the universal problems referenced would be resolved. Braham recommends that people who fear the stigma see the performance.
Nothing will ever get solved by shying away and not addressing the situation or the problem at hand, Braham said. So to someone who is not going to come because of the title Why not give it a shot? Have an open mind. Maybe youre uncomfortable, but isnt that the theater that matters and provokes conversation? I want people to leave, go have dialogue and take action about what they just saw.
The rest is here:
'Vagina Monologues' fights stigma linked to female anatomy - The Ithacan
In an interview with NPR, Kimmel explained the origins of his signature signoff. We had a bad show The guests were bad, and I was feeling pretty bad about myself at the end of the program. And I decided to say, for the amusement of one of our producers who was standing next to me I want to apologize to Matt Damon. We ran out of time. And he got a kick out of it, the producer, so I just started doing it every night to amuse him. Matt Damon was just the first name that popped into my head. I was trying to think of an A-list star, and somebody we absolutely would not bump if he was on the show. The legs on this bit are unbelievable to me. I mean, people laugh every time I say it. Repeating the same joke every single night, youd think eventually people would get tired of it, but they dont.
While the show-ending line kept getting laughs, Damon himself got into the act when Kimmel's then-girlfriend, Sarah Silverman, enlisted the "Bourne Identity" star to appear in the video for her self-explanatory 2008 song, "I'm F***ing Matt Damon".
Kimmel turned the tables on Silverman and Damon in 2009 when Damon's old pal Ben Affleck appeared in Kimmel's response song video, "I'm F***ing Ben Affleck".
This was followed by Kimmel sidekick Guillermo appearing on the set of "The Bourne Ultimatum" only to get beaten up by Damon, who was not too thrilled to see Kimmel's show promoting the upcoming movie as "The Guillermo Ultimatum". Says a ticked-off Damon: "I mean, are you f***ing kidding me?"
Damon got his revenge when Kimmel's fake lover Affleck was joined by John Krasinski, Matthew McConaughey, Patrick Dempsey, Keith Urban, Sting, and Rob Lowe to eject Kimmel from the Handsome Men's Club with the big twist that it was Damon who engineered the entire thing.
In Kimmel's trailer for "Movie: The Movie", a dejected Matt Damon (inexplicably costumed as a bunch of grapes) winds up being cut from the star-studded faux-movie, leading him to send out this pithy response.
In 2013, Damon finally managed to get revenge on Kimmel for all those bumpings, kidnapping the host and hijacking the show, with the help of Andy Garcia and the late Robin Williams.
Kimmel fired back by sending Guillermo to crash the junket for Damon's sci-fi flick, "Elysium", which he took over by promoting a movie HE made, called "Estupido." As Guillermo explains (in Spanish, via subtitles), his film is "about a stupid man who has a friend named Ben, who is also stupid. And he's from Boston. He is very stupid."
Kimmel made Damon pay for his takeover when he and the rest of the cast of "Monuments Men" visited the show, with Damon shuttled off to the side to sit in a tiny stool while the rest of the cast sat in couches.
Finally, the pair decide it's time to try to repair their relationship when Damon visits the show wearing a Dr. Phil disguise. The whole thing, however, is a setup to show a clip of what happened when Kimmel and Damon attended couples counselling. Try to contain your shock, but it did not go well, especially when Damon reveals that he lives "at the show, in a dressing room," in perpetual hope of not being bumped.
When Ben Affleck returned as a guest, he took to the stage wearing a ginormous suit that surprise! actually contained Matt Damon, smuggling him onto the show until Kimmel figures out the pair's scheme.
Kimmel was incensed when he cut to a remote in Vegas, where his Aunt Chippy was playing blackjack until she was accosted by "Matthew from South Detroit," who was actually, as Kimmel described, overrated actor and simpleton Matt Damon.
Damon and Kimmel attempt to give couples counselling another go, but Damon's feelings are hurt when Kimmel is dismissive of his idea for promotional "Bourne" bumper stickers, such as the one that says "Honk if you're Bourney."
When Kimmel decided to run for vice-president, Damon took the low road in a faux political-style attack ad designed to trash-talk the host. Declares Damon solemnly: "If Jimmy Kimmel f***ed Ben Affleck, who's he gonna f*** next? America?"
After Emmy host Kimmel lost to John Oliver at the 2016 Emmys, Matt Damon joined Kimmel onstage, crunching an apple while gloating at Kimmel's loss, reminding him how humiliating it is to have lost "and now you gotta stand out here for the rest of the night in front of everybody." He asked the crowd to try to make Kimmel feel better by giving "the big loser" a round of applause.
Following the New England Patriots' stunning comeback at the 2017 Super Bowl, Damon once again tried to sneak his way onto the show, this time disguised as Pats QB Tom Brady. It doesn't take Kimmel long to figure out Damon's ruse. As he's being escorted offstage by security, Damon yells: "I won the Super Bowl and I won your stupid show!'
Jimmy Kimmel and wife Molly McNearney welcomed their first child a few years ago, and the couple are now expecting a second but is Kimmel really the father? Damon believes HE's the father, and they all appear on Maury Povich's show (with Maury played by Martin Short) to take a paternity test. "We dont know if you're a boy or a girl, but you have a choice of daddies," Damon tells the fetus inside McNearney's belly. "One daddy could be an Emmy loser the other daddy could be an Oscar winner! Do you wanna play with daddy's Oscar?" Tracy Morgan drops in for a twist ending to prove who's REALLY the father.
So will the feud rear its ugly head while Kimmel hosts the Academy Awards. You can count on it. "Im going to do everything I can to make sure that he doesnt win or doesnt know that he won," says Kimmel of his plans for Damon. "My goal is to keep him offstage." Responded Damon: "I'm just sad Chris Rock isn't hosting the show, someone who's actually funny."
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Jimmy Kimmel vs. Matt Damon: Anatomy Of An Epic Hollywood Feud - ETCanada.com
A research team from thePerelman School of Medicine, Universityof Pennsylvania could be onto the next potential anti-aging breakthrough.A study they did, provedthat stem cells extracted from human fat cells could be effective in future anti-aging treatments.
In time, our bodys cells start to lose their regenerative capacity. This largely contributes to our natural ageing process. Stem cells have the potential to slow down or reverse this process, as they have the ability to regenerate and repair our cells. Currently, scientists are already using stem cells in a variety of anti-aging treatments.
FAST FACT: After years of research. Scientists now know that this is due to the shorteningof your DNAs telomeres, which are yourvitality blueprint, and they key to good health and beauty.Ifyou interested in learning more about your telomeres and how you age, follow this link.
The stem cells currently used in anti-aging treatments are usually collected from different tissues found in the adult body. However, this recently published study provesthat adult stem cells collected directly from human fat, called adipose-derived stem cells (ASCs), could be more effective
ASCs producemore proteins than they were originally thought to. This is important because it gives them the ability to hold their integrity when they replicate. Unlike most of your other cells.
Ivona Percec, MD, is the director of Basic Science Research in the Center for Human Appearance as well as this studys lead author. She shares the following, Our study shows these cells are very robust, even when they are collected from older patients.
Unlike other adult human stem cells, ASCs continue to replicate at the same pace throughout your entire life. Not only does it benefit possible future anti-aging treatments. But also to help scientists better understand and study natural aging.
As ASCs help regenerate your body from a cellularlevel. They can also open the door to possible help with the prevention or treatment of age-related diseases. This includes conditions such as Alzheimers, arthritis, type II diabetes and atherosclerosis.
Currently, scientists still need to do a lot more research and tests in order to prove the efficacy of ASCs. In order for FDA approval. We look forward to seeing what progress they make throughout theyear.
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Stem Cells Extracted from Human Fat Could be Used in Future Anti-Aging Treatments - Longevity LIVE
Adult stem cells collected directly from human fat are more stable than other cells such as fibroblasts from the skin and have the potential for use in anti-aging treatments, according to researchers from the Perelman School of Medicine at the University of Pennsylvania. They made the discovery after developing a new model to study chronological aging of these cells.
Chronological aging shows the natural life cycle of the cells as opposed to cells that have been unnaturally replicated multiple times or otherwise manipulated in a lab. In order to preserve the cells in their natural state, Penn researchers developed a system to collect and store them without manipulating them, making them available for this study. They found stem cells collected directly from human fat called adipose-derived stem cells (ASCs) can make more proteins than originally thought. This gives them the ability to replicate and maintain their stability, a finding that held true in cells collected from patients of all ages.
Our study shows these cells are very robust, even when they are collected from older patients, said Ivona Percec, MD, director of Basic Science Research in the Center for Human Appearance and the studys lead author. It also shows these cells can be potentially used safely in the future, because they require minimal manipulation and maintenance.
Stem cells are currently used in a variety of anti-aging treatments and are commonly collected from a variety of tissues. But Percecs team specifically found ASCs to be more stable than other cells, a finding that can potentially open the door to new therapies for the prevention and treatment of aging-related diseases.
Unlike other adult human stem cells, the rate at which these ASCs multiply stays consistent with age, Percec said. That means these cells could be far more stable and helpful as we continue to study natural aging.
ASCs are not currently approved for direct use by the Food and Drug Administration, so more research is needed. Percec said the next step for her team is to study how chromatin is regulated in ASCs. Essentially, they want to know how tightly the DNA is wound around proteins inside these cells and how this affects aging. The more open the chromatin is, the more the traits affected by the genes inside will be expressed. Percec said she hopes to find out how ASCs can maintain an open profile with aging.
Reference:
Shan, X., Roberts, C., Kim, E. J., Brenner, A., Grant, G., & Percec, I. (2017). Transcriptional and Cell Cycle Alterations Mark Aging of Primary Human Adipose-Derived Stem Cells. Stem Cells. doi:10.1002/stem.2592
This article has been republished frommaterialsprovided by Penn Medicine. Note: material may have been edited for length and content. For further information, please contact the cited source.
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Potential of Adipose-derived Stem Cells in Anti-Aging Treatments - Technology Networks (press release) (registration) (blog)