‘Dairy farmers should check out their cows’ anatomy’ – Agriland

If farmers have a better understanding of the cows reproductive anatomy, then it becomes easier for them to understand the factors that come into play when it comes to getting her pregnant, according to UK veterinarian Roger Blowey.

For example, at a very practical level, the tip of an insemination gun should always be placed at the entrance to the cervix during the AI process. If it is pushed up beyond this point, damage to the uterus can result, which will diminish the cows chance of becoming pregnant.

Blowey confirmed that 90% of eggs will be fertilised if the cow is inseminated at the right time.

But problems can follow, when it comes to the new embryo implanting itself onto the wall of the uterus, he said.

This is because the cow does not pick up the signals coming from the fertilised egg and, as a result, does not respond in the ways required to allow implantation.

Blowey said that both external and internal factors can come into play, when determining whether or not implantation can take place.

Extraneous stimuli include lameness, mastitis, over-crowding, poor handling and other management related issues, he added.

Internal factors include endometritis and the physical condition of the uterus. For example, if full involution has not taken place, then the cow will not become pregnant.

This issue raises its head if a cow is inseminated too soon after having her previous calf.

Blowey also highlighted the implications of twin calves a heifer and a bull being born while attached to the same placenta during pregnancy.

Invariably the heifer will be a freemartin.This is because male hormones from the growing bull will be circulating prior to the heifer producing her own compliment of female hormones. As a consequence, the heifer will be born with both male and female sex organs.

Sometimes, the bull calf will be re-absorbed by the mother. However, the resulting single heifer calf will still be a freemartin.

Read more:
'Dairy farmers should check out their cows' anatomy' - Agriland

The anatomy of F1 drivers: from lightning reactions to superstrength necks – Telegraph.co.uk

The neck

In terms of extreme forces they endure, this season we anticipate a greater mechanical grip and faster cornering speeds so we would expect a possible increase in the lateral and longitudinal g-forces which will increase the load on the neck. The neck has to endure a 30-35% increase in load, so the equivalent of about an extra 30-40kg.

Technogym is a partner of ours and they have provided a specific machine known as the F1 Training Machine which enables the drivers to sit in a very specific position and build the right strength. The steering wheel is plate-loaded so you can adjust the position and the load. The drivers can also wear a helmet with attachments of bungee cords which help provide some elastic resistance to simulate the loads they experience in the car.

The drivers also need neuromuscular capabilities so their nervous system needs to be able to react quickly to stimulus on the track, whether that be a move by a fellow competitor, debris on the track, or information or instructions from the pit. They have to make quick decisions in seconds. Driving at such high speeds requires instant decision-making while controlling a million pound machine which is very valuable to the team.

Read the original post:
The anatomy of F1 drivers: from lightning reactions to superstrength necks - Telegraph.co.uk

Ford’s Bridgend engine plant the anatomy of its decline – just-auto.com (subscription)

Employees at Ford's Bridgend Engine Plant, UK, building the 1.6-litre EcoBoost engine

A confluence of factors, many of them rooted in history, are behind theexpected decline in output at Ford's Bridgend plant which will lead to the loss of 1,100 jobs over the next five years.

Firstly, the much-talked about megatrend of engine downsizing has had a marked effect on the addressable market of Bridgend's bread and butter engine of recent years, the Sigma or Zetec-SE, and its proposed successor the Dragon engine (understood to be a 1.2 and 1.5L petrol engine family). The Sigma engine family was introduced in 1995 and produced at both the Bridgend and Valencia, Spain engine plants initially (latterly it's been built further afield). The petrol engine spanned 1.25-1.6L capacity (with a special 1.7L variant developed for the Ford Puma by Yamaha) and its performance was sufficient to make some parts of the bigger capacity Zetec engine 1.6-2.0L petrol engine redundant. They do say what goes around comes around and this became apparent in 2011 when the three-cylinder Fox engine, built in Cologne, Germany and Craiova, Romania was introduced. The Fox engine, necessary to support the required reduction in fleet CO2 emissions under European rules, epitomises downsizing and eroded much of the Sigma's addressable market.

The second major factor is the programme consolidation, known as One Ford, that Ford embarked upon as its signature strategy under Alan Mullaly. While singular global vehicles and platforms may be the visible front for One Ford, it's also a back-office operation for significant components like powertrains. Therefore, whereas in the past, Ford might have been happy to let legacy and older engine programmes continue manufacturing past their European or US market sell-by date in developing markets it is no longer the case. Also, it's the case that regulatory standards in emerging markets are rapidly converging on those in Europe thus enabling a consolidated global approach like One Ford. Thus, the Dragon engine will not only be built in Bridgend but also in India (the lead plant), Brazil, China, Russia and Mexico.

One Ford has had, and will have, other ramifications for Bridgend. It prompted Ford to disband PAG (Premier Automobiles Group) comprising Volvo, JLR and Aston Martin with the first two providing Bridgend with incremental volumes through Volvo's SI6 engine and also JLR's AJ126 and AJ133 engine. The dissolution of PAG saw that the newly independent Volvo and JLR had to develop their own engine programmes. This first saw Bridgend stop building the SI6 engine for both Volvo and JLR. While volumes for the JLR engines have climbed in recent years it is now reported that the JLR contract ends in 2019. At around that time it is thought that JLR will replace the AJ126 V6 with an inline six engine derived from its Ingenium engine programme. Whether the V8 AJ133 will continue manufacture somewhere else is unknown but it's not hard to conceive that boosted versions of the Ingenium inline six could supersede it.

Finally, the uncertainty that Brexit brings over future tariff and trade arrangements will not have helped. In a single European market this is not such a problem. Sure, there is some ForEx risk being outside the Eurozone but the uncertainty brings an added complication that Ford could do without on top of the issues outlined above. Of course, this factor is amplified for Ford in the UK as it no longer manufactures vehicles in the country after shuttering the Dagenham vehicle plant in 2001 and the Southampton Transit plant in 2013. While Dagenham continues to be Ford's centre of excellence for diesel engine manufacture the mounting opposition to diesel in European cities, together with the pressures of manufacturing in a global environment, do start to raise some questions about its longevity after the disclosure of phased job losses at Bridgend.

Ford to lose more jobs at UK engine plant - report

See more here:
Ford's Bridgend engine plant the anatomy of its decline - just-auto.com (subscription)

Many genetic changes can occur early in human development – Science Daily


Science Daily
Many genetic changes can occur early in human development
Science Daily
"The diagnostics lab Baylor Genetics is one of the pioneers in this new era of clinical genomics-supported medical practice and disease gene discovery research," Lupski said. "They are developing the clinical genomics necessary to foster and support ...

Go here to read the rest:
Many genetic changes can occur early in human development - Science Daily

Genetic variant linked to overactive inflammatory response – Medical Xpress

February 28, 2017 Credit: Cardiff University

Researchers at Cardiff University have discovered that genetic variation is the reason why some immune systems overreact to viruses.

Previous research had already revealed that a gene called Ifitm3 influences how sensitive people are to the influenza virus, with a variant form of the gene making cells more susceptible to viral infection. The new research reveals that Ifitm3 also plays an important role in controlling the extent of the inflammatory response triggered by virus infection.

The study suggests that individuals with deficiencies in Ifitm3 may have an overactive immune response to viral infection and may therefore be helped by a combination of anti-inflammatory drugs in addition to medicine that directly targets the virus.

World-wide the frequency of the variant Ifitm3 gene is 1 in 400, although it is much more common in certain ethnicities.

Dr Ian Humphreys from Cardiff University's School of Medicine said: "Now we know that genetic make-up influences how the immune system copes with infections, not only by influencing how the body controls an infection but also by controlling how strongly the body's immune system reacts, we can design therapeutic strategies for individuals who are seriously ill with infections, which are tailored to the individual based on their genetic profile."

The data were collected using immune cells from mice with and without the variant form of Ifitm3, to observe how the immune system responds to a virus called cytomegalovirus. The results could also be relevant for other viral infections such as influenza epidemics/pandemics.

Explore further: Genetics of flu susceptibility: Researchers find gene that can transform mild influenza to a life-threatening disease

More information: Maria A. Stacey et al. The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis, Journal of Clinical Investigation (2017). DOI: 10.1172/JCI84889

Researchers at Cardiff University have discovered that genetic variation is the reason why some immune systems overreact to viruses.

Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a new regulator of the innate immune responsethe immediate, natural immune response to foreign invaders. The study, published recently ...

A new discovery by researchers at the Fred Hutchinson Cancer Research Center in Seattle makes an important step in identifying which specific T cells within the diverse army of a person's immune system are best suited to ...

As much as we try to avoid it, we are constantly sharing germs with those around us. But even when two people have the same infection, the resulting illnesses can be dramatically differentmild for one person, severe or ...

Scientists propose in Nature blocking a molecule that drives inflammation and organ damage in Gaucher and maybe other lysosomal storage diseases as a possible treatment with fewer risks and lower costs than current therapies.

If you've ever wondered how a vaccine given decades ago can still protect against infection, you have your plasma cells to thank. Plasma cells are long-lived B cells that reside in the bone marrow and churn out antibodies ...

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

More:
Genetic variant linked to overactive inflammatory response - Medical Xpress

Mount Tam With Anti-Aging Drug Is Secretly Preparing For Trump’s New FDA – ValueWalk

Mount Tam With Anti-Aging Drug Is Secretly Preparing For Trump's New FDA
ValueWalk
In spite of this, medicine is still based on the old disease model. Doctors wait for a disease to appear and then treat it. Regulators approve drugs to help treat full-blown diseases. This needs to change. But the move from a disease cure to a disease ...

Continue reading here:
Mount Tam With Anti-Aging Drug Is Secretly Preparing For Trump's New FDA - ValueWalk

Miami Beach’s Newest Wellness Institution biostation – Miami’s Community Newspapers

This slideshow requires JavaScript.

The biostation is a comprehensive, individualized, scientific approach to total wellness and age management for men and women looking to rejuvenate their bodies, revitalize their minds and reclaim their confidence. From cosmetic enhancements that help you glow on the outside, to the latest advances in natural healthcare that transform your body from the inside, the biostation will customize a targeted treatment plan designed to get you the results you want.

Having opened its second location on Miami Beach at 777 Arthur Godfrey Road Suite 330, the newest biostation will follow in its Delray Beach flagship footsteps, maintaining the essence of the practice and offering a full range of total wellness and anti-aging services to all of South Florida. The medical center is elegant and spa-like, providing a unique experience to each and every patient. Dedicated Patient Advocates and in-depth personal consultations with their in house Medical Directors, Dr. Bloom and Dr. Shapiro, ensure an exceptional patient-centric experience.

Miami Beach Medical Director, Dr. Jason A. Shapiro, and the biostation Co-Founder, Dr. Martin G. Bloom, have combined their extensive expertise in Medical Aesthetics and Functional Medicine to provide cutting edge total wellness and aesthetic enhancement services designed to help patients beautify and age defy from the inside out.

Dr. Shapiro is a renowned physician Board Certified in Internal Medicine, whose extensive aesthetics training has allowed him to provide his patients with safe, effective, and above all, natural-looking non-surgical and surgical procedures using the most advanced equipment and techniques. Dr. Bloom, a cardiologist of 35 years, decided to embark on his journey in Functional Medicine 5 years ago with the goal of reaching patients earlier in the aging process and providing them with the personal attention and care they deserve. In 2015, Dr. Shapiro partnered with the biostation and Dr. Bloom to expand his highly successful aesthetics practice to include total wellness, anti-aging and medical weight loss services.

The biostation total wellness and anti-aging services:

Comprehensive blood panel, food & allergy testing Hormone Replacement Therapy Nutrient Therapy IV Therapy Medical Weight Loss Platelet Rich Plasma Sexual Health Hair Restoration Lips by Shapiro Botox Dermal Fillers Facial Aesthetics Liposuction & Laser Lipo Kybella Laser Tatoo Removal Surgical Aesthetics

Connect To Your Customers & Grow Your Business

Visit link:
Miami Beach's Newest Wellness Institution biostation - Miami's Community Newspapers

UWSP "tops off"’ $75 million Chemistry Biology Building – WSAW

STEVENS POINT, Wis. (WSAW) -- The Chancellor and onlookers signed a bright purple beam that was placed on top of the new Chemistry Biology Building at UW Stevens Point.

"Today recognizes that the building is not going to get any taller, we're at the highest point of construction," Director of Facilities and Planning for UWSP Carl Rasmussen said.

The $75 million project isn't opening its doors until Fall of 2018, and will be the first brand new academic building on the UWSP campus in more than 45 years.

"Its been intended not only as a science on display facility but in some respects kind of an academic centerpiece for campus, for everyone," Associate Dean for Budget, Personnel and Facilities for the College of Letters and Science Todd Good said.

The 176,500 square-foot facility will be the new home for the university's Chemistry Department and part of the Biology Department.

It will have 39 teaching laboratories along with 19 additional research laboratories.

"The natural sciences and the biology, chemistry and natural resources are really a centerpiece of this campus and one of its academic strengths. We have over 2500 students that are biology or natural resources majors or minors," Good said.

With that many students at the school interested in science programs, the facility could also help the college recruit future biologists and chemists.

"It really signals a commitment that the state, that the college that the campus has to student learning at UW Stevens Point," Good said.

For professors like Paul Hladky, who is the chair of the Chemistry Department, it means getting to use updated technology needed for scientific research in 2017.

"The idea that I'd be back here and I'd see something this phenomenal built on campus is just fantastic," Good said.

Hladky said the layout of the new building is going to be more beneficial to teaching, with the educational laboratories being more open, so all students can see the instructor during class.

He also said that since the building is brand new, it allows the labs to be tailor-made to what technology will benefit students and teachers most while in a classroom setting. He sees it as just one more draw to a school that already has a strong science department.

In total, the building will have five new lecture halls, 58 new laboratories and 45 new faculty and staff offices.

If construction runs on-time and they don't ruin into bad weather, Rasmussen says the building should be complete by the end of 2017, with the building opening up for classes in fall of 2018.

Read this article:
UWSP "tops off"' $75 million Chemistry Biology Building - WSAW

This Company With Anti-Aging Drug Is Secretly Preparing For Trump’s New FDA – Newsmax

As Trump shakes up the White House, pharma and biotech are on edge. While the media talks about Obamacare, it turns out that Trumps new FDA chief could have a bigger impact on health care and associated markets. The story here is that a company in liberal Northern California may have the most to gain from a Trump FDA.

Mount Tam Biotechnologies (MNTM), named for the highest peak of the Marin Hills, is located on the campus of the nonprofit Buck Institute. The Buck was the worlds first institute founded to research aging. Today, its a leader in the emerging field of geroprotection.

The term geroprotection is replacing life extension among scientists. One reason is that many people associate life extension with pseudosciences and health fads. Many also assume it means prolonging the frailty and suffering that comes at the end of life (think Howard Hughes).

Biogerontologists dont want to extend suffering. Rather, their goal is to protect us from the medical and financial effects of aging. They want to extend the healthy portion of our lives (our health spans) for as long as possible. This is known as morbidity compression.

A few decades ago, this goal was science fiction. Most scientists did not think that simple drugs could extend health spans. Thats no longer the case.

Longer Health Spans Are Possible

The cause of this change in attitude is simple. It is the enormous body of research regardingthe mTOR geneand the mTOR pathways.

The Buck Institute has played a major role in that research, acquiring significant legal rights to the drug rapamycin. This drug extends health spans in animals via the mTOR gene pathways. Now, those rights are licensed to Mount Tam.

Studies show that mice given rapamycin in their diets live about 15% longer than untreated mice. Lets put those results into perspective. If we were to put an end to atherosclerosis and cancer in humans, it would extend lifespans by less than 10%.

Even when rapamycin is given to mice that are old, the animals are rejuvenated. They exhibit the traits of younger animals. They show slightly less (but still significant) increases in health spans as the mice that were treated earlier in life.

The Company That Has the Cure for Aging

Increasingly, gerontologists think that age-related diseases are caused by the breakdown of our biological control systems. The immune system is one such control system and it can be modified using rapamycin . This implies that we could treat other systems to prevent or delay age-related disease.

In spite of this, medicine is still based on the old disease model. Doctors wait for a disease to appear and then treat it. Regulators approve drugs to help treat full-blown diseases. This needs to change.

But the move from a disease cure to a disease prevention model is quite complex. One reason is that proving a drugpreventsserious disease is much harder than showing improvement.

Investors have been even slower to catch on to this new paradigm. Thats why the biotech executives that I know think its financial suicide to suggest that a drug has anti-aging properties.

This may be the reason that Mount Tam is silent about the geroprotective impacts of its rapalogs, despite the massive body of research. Rapalogs are variations (or analogs) of the rapamycin molecule genetically engineered to reduce unwanted side effects.Based on its patent application, it seems Mount Tam has produced a rapamycin analog without side effects that would deem it unsafe to regulators.

We have reason to think that both Mount Tam rapalogs would be geroprotective. Rapamycin has, in fact, been used off-label to treat the autoimmune disorder lupus with success.

Mount Tam executives, including the former CEO of the Buck Institute Brian Kennedy, PhD, are not promoting geroprotection as a possible application of its platform. You can imagine that this must be hard for someone who has spent his scientific career pursing anti-aging therapies.

Instead, Mount Tams drug candidates are moving forward aimed at systemic lupus erythematosus and cancer. This makes sense because investors know about these diseases and the potential payoffs.

But President Trump just might change things.

Trumps FDA May Support Geroprotection

One of Trumps leading candidates for FDA chief is Jim ONeill. He has stated that he is committed to an accelerated approval process for geroprotectors.

Another candidate, Joseph Gulfo, supports the approval of drugs based on biomarkers instead of actual lifespan data. In other words, a safe drug that makes you medically younger according to blood and other tests could be approved.

Less is known about a third candidate, Dr. Scott Gottlieb, but he does support FDA reform as well.

In the end, Trumps views on drug approval reform are likely to be more important than those of any FDA chief. And Trump has clearly been listening to billionaire advisor and life-extension advocate Peter Thiel. Thiel believes, as I do, that the only way to fix our medical system is to keep people healthier longer.

This puts Mount Tam in a unique position. Recently, the company signed an agreement with the Buck to license all applications of rapamycin analogs. This includes geroprotection. And behind the scenes, the company seems to be preparing for an FDA change that would support geroprotection. (CEO Richard Marshak has confirmed this to me.) You can read more about Mount Tam and its research in Tech Digest. (subscribe here for free.)

There are other geroprotectors in development, but rapamycin enjoys distinct scientific respect because of the mTOR research.

Subscribe to Patrick Cox's Investment Newsletter,Tech Digest

Be the first to learn about vast profit opportunities most investors have never dreamed of. Biotech expert Patrick Cox spotlights the latest breakthroughs and the innovative companies producing them each weekfrom non-invasive cancer treatments, to age-reversing nutraceuticals, to vaccines that kill any virus.GetTech Digestfree in your inbox every Monday.

2017 Newsmax Finance. All rights reserved.

Read more here:
This Company With Anti-Aging Drug Is Secretly Preparing For Trump's New FDA - Newsmax

Study finds biomarker for lung cancer detection in the nasal passages of smokers – Medical Xpress

February 27, 2017 Lung CA seen on CXR. Credit: James Heilman, MD/Wikipedia

A new nasal test may allow patients suspected of having lung cancer to undergo a simple swab of their nose to determine if they have the disease.

Researchers at Boston University School of Medicine (BUSM) have found that a genomic biomarker in the nasal passage can accurately determine the likelihood of a lung lesion being malignant.

The findings, which appear online in the Journal of the National Cancer Institute, will allow physicians to confidently identify patients who are at low probability for having lung cancer, thus sparing them from costly and risky procedures.

The diagnostic evaluation of lung cancer among high-risk current and former smokers with lesions found on chest imaging (computed tomography or CT) represents a growing clinical challenge given the current clinical recommendations for routine CT screening of high-risk smokers. While there are guidelines for the management of pulmonary nodules, unnecessary, invasive follow-up procedures (including surgical lung biopsy) are frequently performed on patients who are ultimately diagnosed with benign disease.

"Our group previously derived and validated a bronchial epithelial gene-expression biomarker to detect lung cancer in current and former smokers. This innovation, available since 2015 as the Percepta Bronchial Genomic Classifier, is measurably improving lung cancer diagnosis," said corresponding author Avrum Spira, MD, MSc, professor of medicine, pathology and bioinformatics at BUSM. "Given that bronchial and nasal epithelial gene expressions are similarly altered by cigarette smoke exposure, we sought to determine in this study if cancer-associated gene expression might also be detectable in the more readily accessible nasal epithelium."

After examining nasal epithelial brushings from current and former smokers undergoing diagnostic evaluation for pulmonary lesions suspicious for lung cancer, the researchers determined that the nasal airway epithelial field of lung cancer-associated injury in smokers extends to the nose and has the potential of being a non-invasive biomarker for lung cancer detection.

"There is a clear and growing need to develop additional diagnostic approaches for evaluating pulmonary lesions to determine which patients should undergo CT surveillance or invasive biopsy. The ability to test for molecular changes in this 'field of injury' allows us to rule out the disease earlier without invasive procedures," added Spira, who is also director of the BU-BMC Cancer Center and a pulmonologist at Boston Medical Center (BMC).

"Our findings clearly demonstrate the existence of a cancer-associated airway field of injury that also can be measured in nasal epithelium," added Marc Lenburg, PhD, professor of medicine at BUSM and co-senior author. "We find that nasal gene expression contains information about the presence of cancer that is independent of standard clinical risk factors, suggesting that nasal epithelial gene expression might aid in lung cancer detection. Moreover, the nasal samples can be collected non-invasively with little instrumentation or advanced training."

Explore further: Study validates effectiveness of genomic test for lung cancer detection

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Continue reading here:
Study finds biomarker for lung cancer detection in the nasal passages of smokers - Medical Xpress

What is Biochemistry and Why it Matters – Nanalyze

If youre a regular reader of Nanalyze, youll know that were big fans of the work that Bryan Johnson of Kernel is doing, essentially trying to enable read/write access to the brain. In one of his interviews, he remarks thatever since we first booted up a cell with human engineered DNA, we entered a new era that according to his mentor Peter Diamandis, 99.9% of people have no idea weve entered.

What theyre referring to is the fact that humans have essentially discoveredthe Engines of Creation that Eric Drexler was talking about. While everyone is running around slinging political mud at each other like a bunch of primitive monkeys, mankind is working on one of the most transformational technologies that may ever be invented. Its called synthetic biology and its why everyone should have a basic understanding of biochemistry.

When you werechoosing your major in college, you either had your mind set on a particular field already or you needed to peruse all thesubject areas to see what sounded like a good fit. Each subject area will have a certain stereotype associated with it.Some fields sound boring, like electrical engineering or accounting. Some fields sound inherently difficult, like physics or mathematics. Other fieldsyou may not have an idea of what they do because they never sounded compelling enough to research. Thats the case for us withbiochemistry and thats why we thought, as investors, we should edify ourselves on what turned out to be a very relevant and interesting area of the sciences.

If we lookup the basic definition of biochemistry, this is what we get:

the branch of science concerned with the chemical and physico-chemical processes and substances which occur within living organisms.

So its a bit different from chemistry since itsall about the study of chemical processes in living organisms. Heres why it came about according to the American Chemical Society:

Biochemistry emerged as a separate discipline when scientists combined biology with organic, inorganic, and physical chemistry and began to study how living things obtain energy from food, the chemical basis of heredity, what fundamental changes occur in disease, and related issues.

The most basic premise is that you are using living things to take INPUT X and turn it into OUTPUT Y in the most efficient manner possible. If you think about humans as a complex organism, we are able to utilize the equivalent of several pounds of vegetative material to power one of the most complex and amazing machines on the planet. The problem with us though, is that the output from that process has no real use except maybe as fertilizer.

In the U.S. alone, there are approximately 13,500 chemical manufacturing facilities in the United States owned by more than 9,000 companies. These are giant operations which consume a great deal of energy, require a large workforce to maintain, and generate a great deal of pollution. Imagine how much energy and effort goes into building complex mechanical contraptions like this:

Your bog standard chemicals plant

Think about how inefficient these plants have been over the decades as theyve sat there consuming resources and feeding the mass consumerism that we enjoy in todays modern society.Now think about this. What if instead of using these inefficient plants, we engineered biological organisms to produce chemicals by modifying the DNA of the organisms so they did what we needed.The simplest way to think about it is to visualize those punch-cards we used our dads used back in the day. If thats beyond your time, heres what an IBM punch card used to look like:

In the olden days of mainframe computing, we used apunch card like the ones seen above toprovide the computer with a set of instructions. With DNA, its pretty much the same idea except its like havingprecisely these many punch cards:

The above pile of phone books shows roughly the amount of data that a strand of DNA contains, approximately 700gigabytes of data. DNA is one giant punch card that just recently weve been given the hole punch for. That hole punch is called gene editing and its been all over the news lately due to a nasty lawsuit that will determine who has the commercial rights to one of the most exciting discoveries known to man. This biological hole punch called CRISPR will soon let us change every single characteristic we like for any organism and then boot it up so we have our own little biological nanobots doing things for us.Since organisms are the most efficient biological factories (or engines of creation) known to man, it makes sense that we should be modifying them to produce as many industrial chemicals as possible.

The use of synthetic biology for creating things like biofuels (primarily)was off to a rough start as evidenced by the cratering stocks involved in this space like Amyris (NASDAQ:AMRS) and Gevo (NASDAQ:GEVO). Fast forward to today and the potential is even greater but a different model is now being applied. Now you have nanobot factories like Ginkgo Bioworks and Zymergen that areusing artificial intelligence, robotics, and gene editing in order to create little tiny biological chemical manufacturing plants.

Lets say youre a chemical plant that uses a particular enzyme in your production process. You can then go ask Ginkgo or Zymergen to take that enzyme you use and modify it over millions and millions of iterations using the principles of biochemistry. The speed at which they can perform this process has just hit hockey stick growth as seen below:

The end result is an optimized enzyme that meets your requirements and saves you millions of dollars. Startups like this that are using synthetic biology to completely overhaul the industrial chemical manufacturing process are as secretive as you would expect. While we may not have detailed information about what theyre working on, we can take a look at some examples of startups that are using biochemistry and synthetic bioogyin order to create some pretty complex and useful outputs from some basic interesting inputs:

These startups are backed by some big dollars and some big names, however the future business model is a bit hazy here. Will we have the chemical companies going directly to the creators of the synthetic organisms like Ginkgo or will we have startups like the ones mentioned above doing all the production and selling to the chemical companies, only to get acquired once the technology is proven? The one thing that we can be sure of here is that the large chemical producers will profit fromthe use of biochemistry, synthetic biology, and gene editing, consequently we can expect shareholders in these companies to reap the benefits.

If you have children, you maywant to steer them towardsbiochemistry as a major becausethere is a lot of work to do. According to Statista, total revenue of the global chemical industryin 2015 exceeded 5 trillion dollars. This morning when youre tempted to talk about how much political mudslinging there was at the Oscars or who wore the cutest dress, do the world a favor and tell someone how exciting biochemistry is instead.

Looking to buy shares in companies before they IPO?A company called Motif Investing lets you buy pre-IPO shares in companies that are led by JP Morgan. You can open an account with Motif with no deposit required so that you are ready to buy pre-IPO shares when they are offered.

Read more here:
What is Biochemistry and Why it Matters - Nanalyze

Anatomy of a NIMBY – CityLab

Restricting housing construction does not just hurt developersit makes housing less affordable for everyone. But to overcome neighborhood resistance, you need to understand what drives it.

Birds sit on a telephone line near Skid Row Housing Trust's 102 pre-fabricated modular apartments under construction in Los Angeles.

Next week, Los Angeles will vote on Measure S, a ballot initiative that proposes a two-year moratorium on developments that required changes to land use.

The law could potentially limit both new developments and affordable housing. Even with an exception for affordable housing developments written into the law, critics say it could still further restrict affordability in the region.

For a growing chorus of urbanists, NIMBYism and land use restrictions are the culprit behind everything from growing income inequality to shrinking affordable housing, productivity, and innovation. A 2015 study estimated that land use restrictions costs the United States upwards of $1.5 trillion in lost productivity. The 2016 Economic Report of the President called for sweeping reform of zoning and land use restrictions to overcome these costly economic rents, build more housing, and stimulate the U.S. economy.

A recent white paper by Paavo Monkkonen sheds interesting new light on the connection between NIMBYism and housing affordability. It takes a deep dive into, on the one hand, neighborhood opposition and land use restrictions, as well as housing supply and housing costs in Los Angeles, San Francisco, and Californias other expensive housing markets. (The research was partially supported by an unrestricted grant from the Center for California Real Estate to the University of California Center Sacramento Center Housing, Land Use, and Development Public Leadership and White Paper Award.)

California offers an ideal case study in the effects of NIMBYism on housing prices. Its major metrosLos Angeles, San Francisco, Silicon Valley, San Diego, Santa Barbaraare some of the most expensive in the nation. They combine high levels of productivity and high levels of amenitytwo factors which create the high demand which puts pressure on housing prices, and have fallen victim to harsh land use restrictions.

San Francisco Is So Expensive Even Renters Can Be NIMBYs

My own research finds that knowledge and professional workers are able to pay Californias higher housing costs. The burden falls largely on less advantaged blue-collar and service workers who have very little money left over after paying for housing. San Francisco has the highest housing costs in the country, while L.A. has the highest share of rent-burdened households. Across the state as a whole, renters need to make almost four times the state minimum wage to afford an average rent.

The crux of the California problem, the Monkkonen paper argues, is not the states restrictions on uber-high density building in and around urban centers, but the broader dependence on lower-density zoning across the board. Los Angeles may be a relatively dense city and metro (indeed, according to some basic measures, it is the densest metro in the country), but three-quarters of its residential land is devoted to relatively low-density single-family housing that only shelters half the citys population.

But adding new supply in the form of high-rise towers in and around the core will do little to solve the overall housing affordability problem. For one, those towers are usually built for the wealthy, and luxury buildings often boost the price of housing in neighborhoods in and around where theyre built (prompting calls like this one for a luxury housing tax to fund affordable units). They can also displace people from their neighborhoods and change the character of those neighborhoodsthings residents very much care about and will understandably seek to block.

Understanding NIMBYs

To get beyond NIMBYism, we first must understand it. Neighborhood resistance isnt just triggered by residents trying to prop up their home values or protect their neighborhoods from things they dont likeits the product of policies that provide incentives toward homeownership and a regulatory system that encourages and prompts opposition.

Even if the economic arguments about the costs and negative consequences of NIMBYism reflect sound economic logic, they amount to little if they fail to address the very real concerns of neighborhood groups. Most regular citizens and neighborhood residents dont think like dispassionate economists. According to a 2016 Building Industry Association poll, some two-thirds of San Franciscans surveyed do not think increasing housing supply improves affordability. Rather, they believe that land use regulations help to protect their neighborhoods.

Monkkonen goes on to parse four different strains of NIMBYism and their underlying motivations:

To fend off the four flavors of NIMBYism, the paper suggests several strategies:

There are other ways to combat NIMBYism. Yale Law School professor David Schleicher suggests using local tax policy to essentially co-opt NIMBY opposition to new development. The basic idea, referred to as tax increment local transfers, is to allow the residents of neighborhoods to share in the tax revenues that come from new developmentfor example, by rebating and reducing their own property taxes over a period of time. Others suggest that shifting from the current property tax to a land-value tax, which taxes property owners on the underlying value of the land itself, will create better incentives for more intensive land use.

But regardless of the precise mechanism employed, finding better ways to understand and counteract NIMBYism and create more vibrant and affordable cities is one of the most pressing policy issues facing urban America. The need to build more housing without removing community input is, as Monkkonen puts it, "a challenge we can no longer ignore."

Read the original here:
Anatomy of a NIMBY - CityLab

Anti Aging / Age Management Medicine – California Age …

Anti Aging Age Management Medicine. We have been the first full service anti-aging center since 1996.

Why Anti Aging Age Management Medicine? Variably termed holistic, preventive, longevity, regenerative, integrative, complimentary, functional, and/or nutritional medicine.Because you want to look, feel and act like you did 10- 15 years ago. Because you want to be actively engaged in your 60s, 70s and 80s.Because you want to remain competitive in your work or business. And because you owe it to yourself, your family and your work to maintain your optimal health and well being.

We offer long-term solutions, searching for root causes, imbalances and dysfunction not quick fixes.

We promise you Individualized and unsurpassed attention in resolving your challenges and problems. To regain lost energy, youth and vitality.

Our Age Management approach is not drive through medicine. It is not a 15 minute encounter. It is a total look at your entire health blueprint. That is holsistic the total you.

Anti-Aging Age Management Medicine is the new paradigm for the 21st century. It is based on restoring vital function and balance not simply treating symtpoms. Thus, the term functional medicine. We search for root causes and correct these imbalances. It is goal based. Are we achieving your set of goals that you determine?

We have helped thousands over the past 20 years. Now its your time and your turn.

Call us at408-358-8855 or email [emailprotected]

Read more

Original post:
Anti Aging / Age Management Medicine - California Age ...

Power of science: Warriors thrive with chemistry experiment – Daily Commercial

By Janie McCauley / The Associated Press

OAKLAND, Calif. Zaza Pachulia holds his own during competitive games of poker on the airplane alongside Stephen Curry and Klay Thompson they call it the "Good Guys Table." Andre Iguodala and JaVale McGee, one-time teammates with Denver reunited in Oakland, hold secret chats.

"We're building an empire," Iguodala joked. "We've got secret stuff we can't talk about."

Jonnie West son of Hall of Famer and Warriors executive Jerry West joins Curry, Pachulia and Thompson for their card games.

"It depends how Klay feels. If he's tired, then no card game," Pachulia said.

With all that was made before the season about adding Kevin Durant to an already star-studded roster, Golden State's players have jelled just fine. The Warriors are gearing up for what they hope is another championship run, and chemistry sure isn't holding them back.

Two-time reigning MVP Curry and KD love to watch each other accomplish amazing things on the floor, along with Draymond Green and Thompson and all of the others who contribute off the bench.

Curry initially allowed Durant to find his groove, then began to assert himself more and increase his shots. Experience playing together is the biggest factor to keep building team bonds, if you ask Iguodala.

"Weathering storms builds chemistry and adversity builds chemistry," he said. "The season's long and you want to have all types of ups and downs. And that's where you build it the most, and off the court, plane rides. I think when you play with teammates seven, eight years, you're still building throughout that time. You continue to learn about each other. You've just got to understand that that's part of the process and you've got to want to learn from one another."

The Warriors are counting on every advantage they can gain, on and off the court. During flights, team dinners, anywhere.

After a heartbreaking Game 7 to end last season's NBA Finals, Golden State's players want nothing short of a championship. Many of them got a taste winning the title two years ago for the franchise's first in 40 years.

Steve Kerr, the reigning NBA Coach of the Year, gets a kick out of watching his teams come together each year.

"It's one of my favorite parts of coaching honestly, is seeing how a team comes together, seeing the relationships develop, seeing guys laughing together, seeing who hangs out with who," Kerr said. "It's great. This team has a really, really good chemistry that developed really quickly. Obviously, we had the core group intact from last year. We lost some key guys, too. The additions have been great. The chemistry is really good."

Pachulia took it upon himself to be a part of that. With constant attention on the Warriors, he knows the importance of sticking together through all of the many challenges that come in an 82-game season and those things prepare a group for the postseason.

"You wish for the chemistry to come right away because you're kind of feeling pressure, a lot of talk's going on from outside," Pachulia said. "The reality is it's a process. It takes some days, it takes some games. It takes some bumps as well for the team to get on the same page and get the chemistry right. You've got to go through the process. I just don't see it the other way. We couldn't wait for these 40 or 50 games to pass and see where we were going to be. I feel really confident where we are right now, with everything we had throughout this 50 games, even the losses we had unexpected. It made us better, it made us stronger. You can appreciate it, honestly. We care about each other. We're on the same page. Keep going. We're not going to stop."

For Iguodala and McGee, the "chatter" stays between them.

"I have a lot of really in-depth conversations with JaVale McGee," Iguodala said, "about life."

Excerpt from:
Power of science: Warriors thrive with chemistry experiment - Daily Commercial

Decoding the genome’s cryptic language: New tool to map RNA … – Science Daily


Science Daily
Decoding the genome's cryptic language: New tool to map RNA ...
Science Daily
Bioengineers have developed a new tool to identify RNA-DNA interactions. The tool can provide a full account of all the RNA molecules that interact with a ...

and more »

Go here to read the rest:
Decoding the genome's cryptic language: New tool to map RNA ... - Science Daily

Computing with biochemical circuits made easy — ScienceDaily – Science Daily


Lifeboat Foundation
Computing with biochemical circuits made easy -- ScienceDaily
Science Daily
A software tool and a systematic wet-lab procedure proven in practice are an advance in the design and construction of circuits made of DNA.
Computing with biochemical circuits made easy - Lifeboat News ...Lifeboat Foundation (blog)

all 2 news articles »

Read more from the original source:
Computing with biochemical circuits made easy -- ScienceDaily - Science Daily

Students Present Thesis Work at Biophysical Society Meeting – Wesleyan Connection (blog)


Wesleyan Connection (blog)
Students Present Thesis Work at Biophysical Society Meeting
Wesleyan Connection (blog)
Molecular biology and biochemistry graduate student Sudipta Lahiri presented on the Elucidation of the Structure-Function Relationship of S. cerevisiae MutS Homolog Msh4 and Msh5 with the Holliday Junction. Lahiri's advisor is Ishita Mukerji, the ...

Read more:
Students Present Thesis Work at Biophysical Society Meeting - Wesleyan Connection (blog)

Laser Therapy Health & Wellness Center, Inc Hallandale, Florida Expands Innovative Ways To Improve Health For … – PR Newswire (press release)

About Functional Medicine Of total healthcare costs in the United States, more than 75% is due to chronic conditions. The key to reversing the rapidly spreading epidemic of chronic disease is to address the underlying causes and solutions for chronic disease, which are primarily driven by the lifelong, daily interaction among an individual's genetics, environment, and lifestyle choices. Functional medicine not only incorporates the latest in genetic science and systems biology, but it also enables health care practitioners to practice proactive, predictive, personalized medicine while empowering patients to take an active role in their own health. Kristan Weinstein-ANP-BC, is uniquely trained in the functional medicine model to identify and treat the root causes of chronic disease. In order to achieve the designation of A4M- Certified Practitioner, Kristan has completed 7 onsite training seminars and passed stringent written and case study evaluations. Weinstein joins an elite group of practitioners who fully certified in functional medicine

About A4MThe American Academy of Anti-Aging Medicine (A4M) is a US federally registered 501(c) 3 non-profit organization comprised of over 26,000 members including: physicians, health care practitioners, scientists, governmental officials, and members of the general public, representing over 120 nations.

The A4M is dedicated to the advancement of technology to detect, prevent, and treat aging related disease and to promote research into methods to optimize the human aging process. The A4M is also dedicated to educating physicians, scientists, and members of the public on biomedical sciences, breaking technologies, and anti-aging issues.

The A4M is comprised of over 26,000 members from 120 nations worldwide.

Expansion Phase for Timeless Age MedicalLaser Therapy Health & Wellness Center, formerly Laser Therapy Spa, LLC and, Inc has been in business over five years with over six thousand patients to date. With the expansion and upcoming launch of "Timeless Age Medical Group" we plan on serving our patients with the latest 21st century evidence based patient care well into future. Patient health and patient outcome remain our primary concern.

OUR WEBSITES AND SOCIAL MEDIA WILL BE TRANSITIONING TO TIMELESS AGE MEDICAL IN THE COMING WEEKS.

Laser Therapy Health & Wellness Center, Inc (DBA) Timeless Age Medical, Group, Inc 800 East Hallandale Beach Blvd. Suite 15 Hallandale, Florida 33009

PRESS CONTACT

Randi Gold Randigold1.pr@gmail.com http://www.lasertherapyspa.com

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/laser-therapy-health--wellness-center-inc-hallandale-florida-expands-innovative-ways-to-improve-health-for-both-their-patient-base-and-all-of-south-florida-through-its-new-division---timeless-age-medical-group-inc-300413468.html

SOURCE Laser Therapy Health & Wellness Center

http://www.lasertherapyspa.com

Link:
Laser Therapy Health & Wellness Center, Inc Hallandale, Florida Expands Innovative Ways To Improve Health For ... - PR Newswire (press release)

FVCC grad making waves with chemistry invention – Daily Inter Lake

February 24, 2017 at 8:09 pm | By KATHERYN HOUGHTON Daily Inter Lake

WILLIAM PARDIS uses a pHyter to measure the acidity of water at a lab at Flathead Valley Community College on Friday. (Katheryn Houghton/Daily Inter Lake)

A Flathead Valley Community College graduate has tweaked the designs of a $30,000 chemistry machine to make a similar product for less than $100. Now, hes hoping the tool can get in the hands of citizen scientists across the globe.

Friday afternoon, William Pardis, 22, entered the halls of FVCC less than a year after his graduation. He stood before a small audience crammed into a classroom and talked about a box that fit in the palm of his hand.

We could deploy these to people around the world, Pardis said. With this, citizens could develop maps of [oceanic] pH levels and, together, we could better understand whats happening on a global level.

The instrument called a pHyter measures the oceans acidity, or pH levels. Anyone using the handheld, calibration-free tool can download its readings on their smartphone through an app.

Pardis estimated each of his instruments takes about an hour to make and include 10 parts from a 3D printer. The total cost is about $70, not including labor.

FVCC professor David Long said that while chemists have been able to use pH readers to check the oceans acidification, they hadnt created a product that could go anywhere and be used by anyone.

Theyre about $30,000 a piece, so you can imagine, Oh lets put them everywhere on the planet, Thats not going to happen, Long said.

He said measuring acidity reveals how the planet works, as well as the impact of carbon dioxide emissions. Considering 70 percent of the earth is covered in water, its important to understand, Long said.

I think some people are a little baffled by the idea that in Montana, you would have a project thats studying the ocean, Long said. But we want to have a global perspective in chemistry.

PARDIS BEGAN developing the instrument for a physics class in his final year at FVCC. The goal was for the tool to join nine FVCC students on the Pacific island of Moorea in partnership with a UC Berkeley lab last year to monitor the chemical conditions of the ocean.

Friday afternoon, Pardis showed his audience a photo of the island. A light blue ring surrounded the mountainous land, revealing a reef that acted as the instruments perfect testing ground.

His second day on the island, Pardis and Long took the instrument out to the shores edge and tested it with ocean water for the first time.

The numbers of the open ocean measurements that appeared on his screen matched national trends meaning the machine could compete with instruments used by professionals in the field.

Pardis said since he first began developing the pHyter at FVCC, hes created 26 models of the instrument.

As he continues to fine-tune the design, he hopes someday soon it will be used around the world.

About 70 percent of the coastline is under the jurisdiction of undeveloped countries there isnt long-term studies in the area, Pardis said. These instruments allow the research to be more accessible, to citizens and researchers ... to build a more sustained program to document whats going on in our world.

TODAY, PARDIS is a full-time engineering student at Montana State University. Between classes, he assembles variations of his product and ships them to Sunburst Sensors a world-leading chemical sensors manufacturer based in Missoula.

Sunburst then analyzes his work as they partner to modify the tool.

In the meantime, Pardis is getting requests to ship pHyter off to other research centers throughout the country. The National Oceanic and Atmospheric Administration is using Pardis instruments in studies at its marine sanctuary in southern California.

Its an educational tool, he said. Anyone can use one of the instruments, and not only understand the problem better, but be part of the solution.

This summer, Pardis plans to build a freshwater version to test local lakes and rivers.

He said he can make hundreds of the instrument using a 3D printer. But if the pHyters popularity continues to grow, he may have to look for more productive assembly methods.

We know it works, and the market seems to be large, but the next question is, how are we going to meet that [demand], how are we going to produce these things? Im looking into it, Pardis said.

Katheryn Houghton may be reached at 758-4436 or khoughton@dailyinterlake.com.

More here:
FVCC grad making waves with chemistry invention - Daily Inter Lake

New tool to map RNA-DNA interactions could help researchers … – Phys.Org

February 24, 2017 Artistic rendering of RNA-DNA interactions. A 3-D structure of tightly coiled DNA is depicted as the body of a dragon in Chinese myth. Interacting RNAs are depicted as hairs, whiskers and claws, which are essential for the dragon to function. Credit: Victor O. Leshyk

Bioengineers at the University of California San Diego have developed a new tool to identify interactions between RNA and DNA molecules. The tool, called MARGI (Mapping RNA Genome Interactions), is the first technology that's capable of providing a full account of all the RNA molecules that interact with a segment of DNA, as well as the locations of all these interactionsin just a single experiment.

RNA molecules can attach to particular DNA sequences to help control how much protein these particular genes produce within a given time, and within a given cell. And by knowing what genes produce these regulatory RNAs, researchers can start to identify new functions and instructions encoded in the genome.

"Most of the human genome sequence is now known, but we still don't know what most of these sequences mean," said Sheng Zhong, bioengineering professor at the UC San Diego Jacobs School of Engineering and the study's lead author. "To better understand the functions of the genome, it would be useful to have the entire catalog of all the RNA molecules that interact with DNA, and what sequences they interact with. We've developed a tool that can give us that information."

Zhong and his team published their findings in the Feb. issue of Current Biology.

Existing methods to study RNA-DNA interactions are only capable of analyzing one RNA molecule at a time, making it impossible to analyze an entire set of RNA-DNA interactions involving hundreds of RNA molecules.

"It could take years to analyze all these interactions," said Tri Nguyen, a bioengineering Ph.D. student at UC San Diego and a co-first author of the study.

Using MARGI, an entire set of RNA-DNA interactions could be analyzed in a single experiment that takes one to two weeks.

The MARGI technique starts out with a mixture containing DNA that's been cut into short pieces and RNA. In this mixture, a subset of RNA molecules are interacting with particular DNA pieces. A specially designed linker is then added to connect the interacting RNA-DNA pairs. Linked RNA-DNA pairs are selectively fished out, then converted into chimeric sequences that can all be read at once using high-throughput sequencing.

Zhong and his team tested the method's accuracy by seeing if it produced false positive results. First, the researchers mixed RNA and DNA from both fruit fly and human cells, creating both "true" RNA-DNA pairs, meaning they're either fully human or fully fruit fly, and "false" RNA-DNA pairs, meaning they're half human and half fruit flythese are the ones that shouldn't be detected. The team then screened the entire mixture using MARGI. The method detected a large set of true RNA-DNA interactions, but it also detected approximately 2 percent of the false ones.

"This method is not perfect, but it's an important step toward creating a full functional annotation of the genome," said co-first author Bharat Sridhar, a visiting bioengineering researcher in Zhong's group.

Explore further: Size matters... and structure too: New tool predicts the interaction of proteins with long non-coding RNAs

More information: Bharat Sridhar et al, Systematic Mapping of RNA-Chromatin Interactions InVivo, Current Biology (2017). DOI: 10.1016/j.cub.2017.01.011

Far from just reading the information contained in the human genome, and in order to fully understand how it works, researchers aim to know the ins and outs of all the elements in this tiny regulated gear. Many laboratories, ...

Every cell has its own individual molecular fingerprint, which is informative for its functions and regulatory states. LMU researchers have now carried out a comprehensive comparison of methodologies that quantify RNAs of ...

After the 2003 completion of the Human Genome Project which sequenced all 3 billion "letters," or base pairs, in the human genome many thought that our DNA would become an open book. But a perplexing problem quickly ...

What used to be dismissed by many as "junk DNA" is back with a vengeance as growing data points to the importance of non-coding RNAs (ncRNAs)genome's messages that do not code for proteinsin development and disease. ...

An algorithm which models how proteins inside cells interact with each other will enhance the study of biology, and sheds light on how proteins work together to complete tasks such as turning food into energy.

Since the completion of the human genome an important goal has been to elucidate the function of the now known proteins: a new molecular method enables the investigation of the function for thousands of proteins in parallel. ...

Photographers, poachers and eco-tour operators are in the crosshairs of a Canadian conservationist who warns that tracking tags are being hacked and misused to harass and hunt endangered animals.

Bioengineers at the University of California San Diego have developed a new tool to identify interactions between RNA and DNA molecules. The tool, called MARGI (Mapping RNA Genome Interactions), is the first technology that's ...

Small "bubbles" frequently form on membranes of cells and are taken up into their interior. The process involves EHD proteins - a focus of research by Prof. Oliver Daumke of the MDC. He and his team have now shed light on ...

The first skirmish was fought last week in what could be a long war over a revolutionary patent on gene-editing technology, with colossal amounts of money at stake.

Scientists from The University of Western Australia have identified a tiny mutation in plants that can influence how well a plant recovers from stressful conditions, and ultimately impact a plant's survival.

The last Neanderthal died 40,000 years ago, but much of their genome lives on, in bits and pieces, through modern humans. The impact of Neanderthals' genetic contribution has been uncertain: Do these snippets affect our genome's ...

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Follow this link:
New tool to map RNA-DNA interactions could help researchers ... - Phys.Org