Anatomy of a Goal: Kekuta Manneh’s Winner – Massive Report – Massive Report

Welcome to the Anatomy of a Goal, where each week we dissect one goal (or near goal) from the previous weeks Columbus Crew SC match.

For Match 18 of the 2017 MLS Season, we take a look at Kekuta Mannehs 70th minute goal that put Crew SC up 2-1 as part of a 4-1 win over Montreal Impact on Saturday.

Heres a look at the finish from the Columbus winger.

Until Mannehs goal, his first in Black & Gold, Crew SC looked listless after a good start to the match. Federico Higuain opened up the scoring for Columbus in the 17th minute, but the home side gave up a quick equalizer and appeared set for another disappointing match with a blown lead. Luckily that didnt happen.

Full disclosure, this goal is not the most technical Crew SC has scored, but it does provide a few interesting moments of skill. Specifically a moment of either individual brilliance or pure luck by Ola Kamara. The aim here is to spend a chunk of this Anatomy of a Goal showing that Kamara did intend to settle the ball into the path of Manneh rather than inadvertently settling the ball for his teammate.

Mannehs game winner begins with a Jonathan Mensah headed clearance to Higuain. As the headed ball floats toward the Argentinian, Manneh begins his run right by Montreal wing-back Hassoun Camara.

In the magnified circle, you can just see that Higuains head is turned toward Manneh as he tries to wrangle a difficult bounce. Higuain can see Manneh making his run against the much slower Camara.

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In the above video, you can see Columbus No. 10 display a deft bit of skill to juggle the ball over the defender and send a perfect one-time ball into the path of the streaking Manneh. The Crew SC attacker is in incredible form having scored five goals in his last four matches.

As Manneh chases down the ball, hidden just behind Camara, he has beaten his man and only has Wandrille Lefevre between him and the goal. At this point, Manneh has not yet put a touch on the ball.

As Lefevre begins to close him down, Manneh chests the ball forward, his first touch of the game, which is just a bit too heavy and will allow Lefevre to get in front of him.

The ball continues forward and Lefevre uses his body to take Manneh out of the play just outside the 18-yard box. Manneh doesnt fall, though he arguably would have been given the foul call had he gone to the ground.

Camara recovers on the ball and should be able to clear it forward. Just to his right, Manneh gets around Lefevres screen. Kamara continues his run at pace, heading right for the ball and Camara.

Under little pressure, Camara cant get turned quickly enough and loses the ball off of his right shin. Both Manneh and Kamara continue their runs, looking to punish Montreal for Camaras clumsy touch.

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Finally, we are at the point where this goal gets interesting. In the above video, Kamara looks to clumsily misplay the ball conveniently into the path of Manneh. After closer examination, its clear that Kamara fakes a shot with his left foot and intentionally settles for his teammates first goal. Lets look at Kamaras touch in stills and a few more angles.

From the broadcast camera, you can just see Kamara slow the ball with his right, trailing, foot as an unmarked Manneh looks on.

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From a slightly different angle, you can see Kamara swing his left foot forward and catch the ball with his right foot. On first glance, it looks like the Kamara misses his left -footed shot and incidentally catches the ball with his right, trailing, foot. Two pieces of evidence from this video suggest otherwise.

First, watch Kamaras head during this play. As he swings over the ball and touches it with his right foot, the Crew SC striker turns his head around to see where he left the ball. This looks like an intentional movement to watch the play that he has just set up.

Second, notice the movement of the ball in this and the remaining highlights. As Kamara touches the ball with his right foot, the ball travels back and to the left, slowing down right in the path of Manneh. Again, this looks like an intentional movement.

In the above image from the same angle, Kamara looks to be setting up a shot. He has a clear view of both Manneh and Camara. However, Kamara doesnt rotate his hips. From this angle, a shot would land somewhere between the left post and the corner flag. Kamara, who scored his 25th goal in just over a year and a half in Columbus on Saturday, is an expert at rotating his hips toward goal. Again, this is an intentional movement.

The above photo provides a better look at Kamaras flick back to Manneh. In this still, it appears that Kamara is swinging his right leg back and to the left, so his touch will send the ball near Manneh.

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Kamaras fake shot and deft touch stand out even more on this angle. In the above video you can see Kamara take a short windup as if hes going to shoot, and then clearly flick the ball back and to the left with his right foot. The motion of his right foot, a quick flick, is definitely not the motion of someone who has just whiffed on a shot.

Again, Kamara winds up for his shot. Slowed down and over-analyzed, its clear that Kamara will not shoot the ball. However, at speed, this shot is incredibly effective at freezing the defending Camara.

Here, Kamara watches his flick back and to the left into the path of Manneh. Once again, this is an intentional motion.

With the ball now at his feet. . .

Manneh buries the shot for his first goal of the season.

But wait!

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Another video has emerged, from Crew SCs Instagram account, that provides a clearer picture of Kamaras clever touch to Manneh. In the above video you can clearly see Kamara drag his left leg over the ball and then flick a pass back and to the left, right into the path of Manneh.

Findings:

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Anatomy of a Goal: Kekuta Manneh's Winner - Massive Report - Massive Report

Cloning thousands of genes for massive protein libraries – Phys.Org

June 26, 2017 New DNA-based LASSO molecule probe can bind target genome regions for functional cloning and analysis. Credit: Jennifer E. Fairman/Johns Hopkins University

Discovering the function of a gene requires cloning a DNA sequence and expressing it. Until now, this was performed on a one-gene-at-a-time basis, causing a bottleneck. Scientists at Rutgers University-New Brunswick in collaboration with Johns Hopkins University and Harvard Medical School have invented a technology to clone thousands of genes simultaneously and create massive libraries of proteins from DNA samples, potentially ushering in a new era of functional genomics.

"We think that the rapid, affordable, and high-throughput cloning of proteins and other genetic elements will greatly accelerate biological research to discover functions of molecules encoded by genomes and match the pace at which new genome sequencing data is coming out," said Biju Parekkadan, an associate professor in the Department of Biomedical Engineering at Rutgers University-New Brunswick.

In a study published online today in the journal Nature Biomedical Engineering, the researchers showed that their technologyLASSO (long-adapter single-strand oligonucleotide) probescan capture and clone thousands of long DNA fragments at once.

As a proof-of-concept, the researchers cloned more than 3,000 DNA fragments from E. coli bacteria, commonly used as a model organism with a catalogued genome sequence available.

"We captured about 95 percent of the gene targets we set out to capture, many of which were very large in DNA length, which has been challenging in the past," Parekkadan said. "I think there will certainly be more improvements over time."

They can now take a genome sequence (or many of them) and make a protein library for screening with unprecedented speed, cost-effectiveness and precision, allowing rapid discovery of potentially beneficial biomolecules from a genome.

In conducting their research, they coincidentally solved a longstanding problem in the genome sequencing field. When it comes to genetic sequencing of individual genomes, today's gold standard is to sequence small pieces of DNA one by one and overlay them to map out the full genome code. But short reads can be hard to interpret during the overlaying process and there hasn't been a way to sequence long fragments of DNA in a targeted and more efficient way. LASSO probes can do just this, capturing DNA targets of more than 1,000 base pairs in length where the current format captures about 100 base pairs.

The team also reported the capture and cloning of the first protein library, or suite of proteins, from a human microbiome sample. Shedding light on the human microbiome at a molecular level is a first step toward improving precision medicine efforts that affect the microbial communities that colonize our gut, skin and lungs, Parekkadan added. Precision medicine requires a deep and functional understanding, at a molecular level, of the drivers of healthy and disease-forming microbiota.

Today, the pharmaceutical industry screens synthetic chemical libraries of thousands of molecules to find one that may have a medicinal effect, said Parekkadan, who joined Rutgers' School of Engineering in January.

"Our vision is to apply the same approach but rapidly screen non-synthetic, biological or 'natural' molecules cloned from human or other genomes, including those of plants, animals and microbes," he said. "This could transform pharmaceutical drug discovery into biopharmaceutical drug discovery with much more effort."

The next phase, which is underway, is to improve the cloning process, build libraries and discover therapeutic proteins found in our genomes, Parekkadan said.

Explore further: Technical advances in reading long DNA sequences have ramifications in understanding primate evolution, human disease

More information: Long-adapter single-strand oligonucleotide probes for the massively multiplexed cloning of kilobase genome regions, Nature Biomedical Engineering (2017). DOI: 10.1038/s41551-017-0092

Technical advances in reading long DNA sequences have ramifications in understanding primate evolution and human disease.

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Cloning thousands of genes for massive protein libraries - Phys.Org

Personal chemistry key as Trump meets India Prime Minister for first time – Chicago Tribune

President Donald Trump meets for the first time Monday with India's Prime Minister Narendra Modi, and personal chemistry as much as policy could determine the direction of future relations.

The leaders of the world's two largest democracies will convene at the White House. They will look to expand ties on defense and fighting terrorism, but strains are likely on trade.

Trump has so far focused on outreach to China, India's strategic rival, as he looks to Beijing to rein in nuclear-armed North Korea. But Washington and New Delhi share concerns about China's rise as a military power that has underpinned increasingly close relations in the past decade.

The Trump administration says it wants to provide India the kind of defense technology it does to the closest U.S. allies. In a concrete indication of that, the U.S. is set to offer a $2 billion sale of U.S.-made unarmed drones to help in surveillance of the Indian Ocean.

Although Modi's two-day Washington visit, which began Sunday, is lower key than his previous three trips to the U.S. since he took office in 2014, there will be plenty opportunity for face time with Trump.

After their talks, Modi and Trump will make statements in the Rose Garden. Modi will also have dinner with the president and first lady the first dinner Trump has hosted for a foreign dignitary at the White House, although he has hosted the leaders of Japan and China at his resort in Florida.

Before he goes to the White House, Modi will meet separately on Monday with Secretary of State Rex Tillerson and Defense Secretary Jim Mattis.

Trump and Modi share a populist streak and a knack for social media, but their economic nationalist agendas could clash. While Trump champions the idea of "America First" and wants to stop the migration of jobs overseas, Modi has his own drive to boost manufacturing at home, dubbed "Make in India."

India is among the nations singled out by the Trump administration for their trade surpluses with the U.S., and it is also reviewing a visa program used heavily by skilled Indian workers.

Both sides want better market access. U.S. is seeking stronger Indian protection of intellectual property rights, reductions in tariffs and narrowing of the $30 billion trade deficit. India has its own concerns, including over regulatory barriers faced by its producers of generic medicinal drugs.

Michael Kugelman, a South Asia expert at the Wilson Center, predicted that Wednesday's summit would be a "no-frills, let's get acquainted affair" whose outcomes, from their body language to the post-meeting joint statement, will offer clues about the future of U.S.-India relations.

"For Trump, the personal is political," said Atman Trivedi, an Asia specialist at Hills & Company consultancy.

On fighting terrorism, Kugelman said the two leaders have a similar worldview that "it needs to be destroyed wherever it rears its murderous head."

Modi will be hoping that as well as tackling the Islamic State, Trump will step up pressure on militant groups based in Pakistan accused of launching attacks on India. He'll also want to learn about the administration strategy to stabilize Afghanistan, where India has committed $3 billion in aid since 2001.

Climate change could be a contentious issue. New Delhi was irked by Trump's decision to pull out of the Paris accord, and his claim that India had made its participation contingent on receiving billions in foreign aid. India denies that and says it will continue to be part of the accord, regardless of U.S. participation.

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Personal chemistry key as Trump meets India Prime Minister for first time - Chicago Tribune

The Giants chemistry is suffering because a guy they all hated is gone – Yahoo Sports

Ive spent years arguing with people about team chemistry. You know the battle lines on all of that now: people who talk a lot about team chemistry tend to attribute winning or losing to good or bad chemistry, respectively. I tend to think that characterizing chemistry is a retroactive exercise in which teams that win are happy and then cite their happiness as the reason and vice versa. Jim Leyland agrees with me, for what its worth, so Im pretty happy with my take.

Not that Ill claim a monopoly on wisdom here. Ive never played on a professional baseball team. I dont know what its like to try to prepare to play baseball while surrounded by jackwagons who dont get along with anyone. I cant imagine that makes life easier. Indeed, based on the testimony of players I have spoken to, I will grant thatthere is at least some intangible yet real benefitif everyone is happy an gelling. I dismiss team chemistry arguments for the most part, but if I ran a team Id at least try to get rid of bad seeds if their bad seeding was not outweighed by seriously outstanding on-the-field play. You want your workers happy, folks.

All of which makes me wonder what the heck to do about this passage from Ken Rosenthals latest column. Its about the reeling San Francisco Giants. They have all kinds of issues their offense is putrid, their pitching isnt much better and theyve been without their ace most of the year but today Rosenthal looks at their team chemistry. Its a quiet and subdued clubhouse, he notes, and it has a lot of people wondering if something is wrong there. What could it be?

Sandoval, who was an often noisy and boisterous presence during his time with the club, departed as a free agent after that season. Pence has suffered a number of injuries in recent years and declined offensively, making it difficult for him to be as vocal as he was in the past. Some with the Giants muse that the team even misses Angel Pagan, who created an odd sort of unity because most of the players disliked him.

Read that last sentence again. And then go on with your talk about how team chemistry is a legitimate explanatory concept regarding what makes teams win or lose as opposed to a post-hoc rationalization of it.

Not that its not a good article overall. Theres some interesting stuff about the Giants bullpen culture. And, of course, we now know why no one signed Pagan last winter.

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The Giants chemistry is suffering because a guy they all hated is gone - Yahoo Sports

The Nats are going to sign Francisco Rodriguez for some reason – HardballTalk (blog)

The Nationals bullpen is a tire fire. Theyre about to add another tire. Per Jon Heyman of FanRag Sports, Washington is about to sign free agent reliever Francisco Rodriguez.

K-Rod was released by the Tigers last week after posting an ERA of 7.82 over 28 appearances this season. He has a 1.658 WHIP, is allowing 11.9 hits per nine innings and is posting his highest walk rate in five years. Also worth noting: the Detroit Friggin Tigers decided that he was not good enough to be in their bullpen.

So, yeah, good luck with that Washington.

Ive spent years arguing with people about team chemistry. You know the battle lines on all of that now: people who talk a lot about team chemistry tend to attribute winning or losing to good or bad chemistry, respectively. I tend to think that characterizing chemistry is a retroactive exercise in which teams that win are happy and then cite their happiness as the reason and vice versa. Jim Leyland agrees with me, for what its worth, so Im pretty happy with my take.

Not that Ill claim a monopoly on wisdom here. Ive never played on a professional baseball team. I dont know what its like to try to prepare to play baseball while surrounded by jackwagons who dont get along with anyone. I cant imagine that makes life easier. Indeed, based on the testimony of players I have spoken to, I will grant thatthere is at least some intangible yet real benefitif everyone is happy an gelling. I dismiss team chemistry arguments for the most part, but if I ran a team Id at least try to get rid of bad seeds if their bad seeding was not outweighed by seriously outstanding on-the-field play. You want your workers happy, folks.

All of which makes me wonder what the heck to do about this passage from Ken Rosenthals latest column. Its about the reeling San Francisco Giants. They have all kinds of issues their offense is putrid, their pitching isnt much better and theyve been without their ace most of the year but today Rosenthal looks at their team chemistry. Its a quiet and subdued clubhouse, he notes, and it has a lot of people wondering if something is wrong there. What could it be?

Sandoval, who was an often noisy and boisterous presence during his time with the club, departed as a free agent after that season. Pence has suffered a number of injuries in recent years and declined offensively, making it difficult for him to be as vocal as he was in the past. Some with the Giants muse that the team even misses Angel Pagan, who created an odd sort of unity because most of the players disliked him.

Read that last sentence again. And then go on with your talk about how team chemistry is a legitimate explanatory concept regarding what makes teams win or lose as opposed to a post-hoc rationalization of it.

Not that its not a good article overall. Theres some interesting stuff about the Giants bullpen culture. And, of course, we now know why no one signed Pagan last winter.

Giants ace Madison Bumgarner tossed three no-hit innings yesterday in his first minor league rehab start with the Giants Arizona Rookie League team. He struck out two and walked a guy, while sitting in the 88-91 m.p.h. range on his fastball.

Bumgarner, who is coming back from a sprained left AC joint in his shoulder suffered in a dirt bike accident in April, will return to San Francisco to throw a bullpen session and then go back on the road for more rehab games. Thats a lot of traveling, but the Giants obviously want to monitor his progress. At the moment hes expected to build up his strength for the next several weeks and, hopefully, return to the Giants rotation some time after the All-Star break.

Of course, there shouldnt be too much of a rush. The Giants have lost five in a row and 12 of 13 and currently sit in last place, 24.5 games behind the Dodgers. At this point Bumgarner rushing to rejoin the Giants is like an Australian soldier getting a wound dressed to hurry back to the Gallipoli Campaign.

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The Nats are going to sign Francisco Rodriguez for some reason - HardballTalk (blog)

New insights into the toxin behind tetanus – Phys.org – Phys.Org

June 26, 2017

Tetanus toxin is the neurotoxin that causes lockjaw. Many are vaccinated, but tetanus still kills tens of thousands of people per year worldwide. Researchers from the Department of Biochemistry and Biophysics, led by Dr. Pl Stenmark, have now uncovered the poison's structure. For the first time, the way the poison is constructed has been revealed.

"Our discovery could be used to design new medicines", says Pl Stenmark, Associate Professor at the Department of Biochemistry and Biophysics, Stockholm University.

Dr Stenmark and his research team have determined the three-dimensional structure of the entire tetanus toxin protein.

"We can now see the exact positions of the 20 000 atoms that build up the tetanus toxin. It means that we can see how both the toxin and vaccine actually look. Botulinum neurotoxins and the tetanus toxin are the deadliest toxins known to man. The toxins are large proteins that are made by specialised bacteria. The bacteria that produce the tetanus toxin are found in common soil and flourish in untended wounds. One unusual feature of the tetanus toxin is that it travels in nerve cells to the spinal cord from where it can cause life-threatening cramping and spasms."

These start with the shorter nerves in the face (lockjaw) and move on to cause spasms violent enough to break bones.

"We discovered that the poison takes on different forms depending on pH - it appears one way in acidic liquids and very different in a neutral pH environment. We believe that this is important for the toxins ability to move from the wound to the spinal cord and to adapt to different environments. Before this research, no one knew what the toxin looked like or that it changed structure depending on pH."

Pl Stenmark's research group also studies the botulinum neurotoxins, which are similar to the tetanus toxin, but causes paralysis instead of spasms and cramping.

"We want to know more about why these two poisons have nearly opposite effects - tetanus toxin travels through nerve cells to the spinal cord and cause severe muscle cramps whereas the botulinum neurotoxin stays put and causes paralysis. Our findings could be useful in creating new medicines that could be transported to the brain", says Pl Stenmark.

"People are not vaccinated against tetanus in many parts of the world, and infants and new mothers are particularly at risk. Large international vaccination programs have dramatically improved the situation, but tens of thousands of people still die of tetanus every year."

Explore further: Secret of tetanus toxicity offers new way to treat motor neuron disease

More information: Geoffrey Masuyer et al, The structure of the tetanus toxin reveals pHmediated domain dynamics, EMBO reports (2017). DOI: 10.15252/embr.201744198

Journal reference: EMBO Reports

Provided by: Stockholm University

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New insights into the toxin behind tetanus - Phys.org - Phys.Org

Tom Yamachika: Anatomy Of The Epic Fail On Rail – Honolulu Civil Beat

The Senate Ways and Means Committee took a very different tack. Its 10-page version basically said, Well take away the States 10 percent skim off the surcharge, but no extension; youre on your own.

That draft unanimously passed the full Senate and went over to the House.

House Finance Committee Chairwoman Sylvia Luke and Senate Ways and MeansChairwoman Jill Tokudaplayed key roles in the various drafts of the rail tax bill.

Cory Lum/Civil Beat

There, the House Transportation Committee kept the bill alive by putting blanks in it its draft extended the tax to an unspecified date, reinstated the skim but replaced the percentage with a blank percent to recover the states costs and a blank percent that would go the DOT for state highway projects.

The House Finance Committee then filled in the blanks, extending the tax for two years, and dropping the skim to 1 percent, none of which would be earmarked for the DOT.

This version went to the conference committee, and then surprising things started happening.

First, the Senate proposed a new draft, radically different from the version that passed the Senate, which extended the surcharge for 10years and raised the skim to 20 percent.

The House came back with a draft that left the GET surcharge untouched, dropped the skim to 1 percent and raised the hotel room tax from 9.25 percent to a hefty 12 percent.

The latter proposal, though innovative, caught the hotel industry unaware, prompting vigorous objections. Then-Senate money chair Tokuda agreed to that version with tweaks a few hours later, thereby making the final decking deadline.

After frantic meetings through the weekend, the money chairs, apparently with some members of the hotel industry, reached a compromise involving a shorter GET extension and a lower TAT hike.

Amendments were introduced on the chamber floors to implement the agreement, although another version with only a GET extension and no TAT increase, which Honolulu Mayor Kirk Caldwell supported, was circulating in the Senate.

The House passed one version and jettisoned its speaker, while the Senate adopted the other version and deposed Chairwoman Tokuda.

With no agreement between the chambers, neither version can be enacted. That is where we are now.

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Tom Yamachika: Anatomy Of The Epic Fail On Rail - Honolulu Civil Beat

Chemical attraction: Scottsdale teen in national chemistry competition – Cronkite News

By Emma Lockhart | Cronkite News Thursday, June 22, 2017

WASHINGTON You might not know which chemical element in the Hope Diamond has the largest molecular mass, but an eighth-grader from Scottsdale does.

Isaiah Hazelwood faced that and other questions faced earlier this week when he squared off against other middle school students from around the country as part of the You be the Chemist National Challenge in Washington.

The lanky 13-year-old whos in the eighth grade at Basis Scottsdale won the state competition in February to advance to the nationals on Monday, competing against 41 other students representing 39 states, Puerto Rico and the District of Columbia.

The competition drew a total of 55,000 students at the local and state levels, according to a prepared statement from Dwayne Sattler, executive director of the Chemical Education Foundation, which sponsored the contest.

Students like Isaiah, who are excited about particular subject areas, certainly dive a little bit deeper and our teachers help work with them to foster that excitement, Basis Scottsdale Principal Kristen Jordison said by phone this week.

Between rounds, Isaiah spoke quietly and looked away during interviews until the conversation turned to chemistry. Then, he lit up.

Im excited about chemistry because it just tells us so much about how the world works and how we work, Isaiah said Monday.

The competition, sponsored by the Chemical Educational Foundation, featured four rounds of competition, with students eliminated in each round.

But unlike the more familiar spelling and geography bees, where individual students face the glare of the spotlight as they try to answer a question, the chemistry students remain seated on stage where they all saw the same question at once. Giant screens projected timed multiple-choice questions that the students answered using individual clickers.

-Cronkite News video by Emma Lockhart

All 42 students started in the first, preliminary round in a Washington hotel ballroom with the students in seated rows on the stage as educators, organizers, sponsors and others watched from round tables in the audience.

Im excited about the having completed the preliminary rounds however the questions are a bit harder than I expected, Isaiah said after one of the early rounds. Im not all that certain Ill get into a top four spot.

The questions, some of which were at the level of an AP class, were a challenge even for some teachers.

They are tough questions, said Kaitlyn Mandigo, a BASIS Scottsdale chemistry teacher who was in Washington for the competition. As a person with a chemistry degree, there were some that I really had to pause and think about.

Isaiah was able to survive and advance to the second round with 14 other students but did not make the next cut, down to four finalists.

Miss USA Kara McCullough, who has a bachelors degree in chemistry, spoke at the event and awarded the winning prize which included a calculator as well as a trophy to eventual champion, Anantahn Sadagopan, 13, from Massachusetts. He also won a $12,000 scholarship.

But for Isaiah, there was more to the trip than winning. And chemistry, surprisingly.

Coming here I was excited to see all of the monuments and memorials in D.C., he said this week. We may be staying here a few extra days to catch up on all of the memorials and monuments and buildings.

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Chemical attraction: Scottsdale teen in national chemistry competition - Cronkite News

Eli Lilly Unveils $90M Expanded Biotechnology Center in San Diego – Times of San Diego

Share This Article: Eli Lilly and Company logo. (PRNewsFoto, Eli Lilly and Company)

Pharmaceutical giant Eli Lilly announced the completion of a $90 million expansion of its San Diego biotechnology center, which is now more than double its previous size with the addition of 180,000 square feet of work space.

The facility, on Campus Point Drive near UC San Diego, also includes a new high-tech laboratory and room for what the Indianapolis-based company calls a Life Science Studio.

Eli Lilly moved into San Diego in 2004 with the acquisition of Applied Molecular Evolution Inc., and built its Biotechnology Center in 2009.

Being in the San Diego area for the last 13 years has been a game changer for us, specifically in the arena of discovering medicines for hard-to- treat autoimmune conditions, said Thomas F. Bumol, Lillys senior vice president of biotechnology and immunology research.

Company officials said they hope the new facility will allow closer collaboration among researchers. The center originally focused on immunology, but in the larger facility, scientists will also work on diabetes, oncology, neurodegeneration and pain reduction.

Investing in drug discovery and development is critical to maintaining an ecosystem that encourages and promotes innovation, said Jan Lundberg, executive vice president for science and technology and president of Lilly Research Laboratories.

Our expansion in San Diego is a prime example of investing in a research success story, Lundberg said. Expanding our presence in San Diego will not only help us discover and deliver innovative medicines faster, but will also help us achieve our goal of launching 20 new medicines in 10 years.

According to Eli Lilly, the Life Science Studio will allow researchers across the globe to remotely design, synthesize and screen molecules in an unprecedented manner, expanding the ability of scientists to test new ideas, reduce costs and minimize environmental impacts.

City News Service

Eli Lilly Unveils $90M Expanded Biotechnology Center in San Diego was last modified: June 23rd, 2017 by Debbie L. Sklar

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Eli Lilly Unveils $90M Expanded Biotechnology Center in San Diego - Times of San Diego

Finn Named Academic All-American of the Year for Women’s Track and Cross Country – MGoBlue

June 23, 2017

Erin Finn was named the CoSIDA Academic All-American of the Year for the 2016-17 women's track and field / cross country seasons. This marks the second consecutive season Finn has been named a first-team Academic All-American. Finn is the third Wolverine -- all from the track and field / cross country programs -- to earn the award, joining two-time winner Lindsey Gallo and Kevin Sullivan.

ANN ARBOR, Mich. -- University of Michigan senior Erin Finn was voted Academic All-American of the Year for women's track and field / cross country and named to the Academic All-America first team for the second consecutive season, the College Sports Information Directors of America (CoSIDA) announced Friday (June 23).

On the combined strength of her national runner-up showings during the indoor track and field / cross country seasons and her near-flawless cumulative undergraduate grade point average as a standout biochemistry student, Finn was selected from among the Academic All-District honorees announced this May in a vote by the CoSIDA Academic All-America committee.

Already among the best-of-the-best in Michigan track and field / cross country history based on her record in competition, Finn now joins a select group in school history who have earned this highest academic distinction that now numbers three: Finn, two-time winner Lindsey Gallo (2004-05) and current men's cross country coach Kevin Sullivan (1998).

Finn's honor marks the seventh time in the past eight years that U-M has had at least one honoree named to the first, second or third team.

Finn was twice an individual national runner-up during the 2016-17 academic year, which culminated in the completion of her undergraduate biochemistry degree with an impeccable 3.98 GPA. For her efforts in the classroom, she earned the 2017 American Institute of Chemists Award for Biochemistry.

She attained this excellence in the classroom while continuing to assert herself as one of the nation's premier long-distance runners.

Finn competed for the Wolverines during both the cross country and indoor track and field seasons in 2016-17, amassing a near-peerless competitive resume that included national runner-up finishes in both sports, a Big Ten title and a regional title.

In cross country, she finished second in the country at the NCAA Championships to lead Michigan to a narrow runner-up national team finish -- tied for the best team finish in program history with the 1994 runner-up squad. Along the way, she won individual Big Ten and Great Lakes Regional titles with team trophies to match.

Indoors, she became the first woman in collegiate history to run 15:30 or faster over 5,000 meters at two consecutive NCAA Indoor Championship meets as she finished as the national runner-up at that distance. She was third at the Big Ten Indoor Championships at both 3,000 and 5,000 meters.

Though her 2017 NCAA outdoor track and field season came to a premature conclusion, she returned for her outdoor debut at the 2017 USATF Outdoor Championships Thursday night (June 22) with a Michigan- and Big Ten-record 32:00.46 clocking over 10,000 meters to finish sixth overall and move to No. 9 on the all-time collegiate performers list.

Finn will return for one final year in both indoor and outdoor track in 2018 as she pursues a master's of public health degree in epidemiology.

CoSIDA Release

Communications Contact: Kyle Terwillegar

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Finn Named Academic All-American of the Year for Women's Track and Cross Country - MGoBlue

Lilly Completes $90M Expansion of San Diego Biotechnology Center – Genetic Engineering & Biotechnology News

Eli Lilly has added a new state-of-the-art laboratory and 180,000 square feet of additional working space to its Biotechnology Center in San Diego, CA. Reporting completion of the $90-million expansion, Lilly said the 145% increase in working space will help to foster collaborations with external partners, and allow closer partnerships between its biotechnology, discovery chemistry, and research technology teams. The aim is to accelerate drug discovery within therapeutic areas including immunology, diabetes, oncology, neurodegeneration, and pain.

To further exploit its expertise in automated organic synthesis, and build on its Automated Synthesis Laboratory in Indianapolis, Lilly is also establishing the Lilly Life Science Studio at the San Diego site. The firm says the new facility will give researchers worldwide the ability to remotely test new ideas, and design, synthesize, and screen molecules.

"Investing in drug discovery and development is critical to maintaining an ecosystem that encourages and promotes innovation, commented Jan Lundberg, Ph.D., executive vice president for science and technology and president of Lilly Research Laboratories. "Expanding our presence in San Diego will not only help us discover and deliver innovative medicines faster, but will also help us achieve our goal of launching 20 new medicines in 10 years."

"This year we announced a commitment to invest $850 million in our U.S. operations based on our potential for growth and the company's long-standing investment in the U.S. market, added David A. Ricks, Lilly's chairman, president, and CEO. "This investment doesn't come without risk. America's biopharmaceutical leadership is driven by a free-market economy that rewards innovation. Today, there are multiple public policy threats to our business that would discourage or reduce our investment in the U.S. and the state. We are committed to working with policymakers and stakeholders to ensure our efforts to deliver new innovative medicines to patients are not threatened."

Lilly set up the San Diego Biotechnology Center, which is sited close to the University of California, San Diego, in 2009, having acquired Applied Molecular Evolution back in 2004.

Earlier this month Lilly reported that it will acquire a pipeline of dual amylin calcitonin receptor agonists (DACRAs) from KeyBiosciencefor the potential treatment of type 2 diabetes and other metabolic disorders.

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Lilly Completes $90M Expansion of San Diego Biotechnology Center - Genetic Engineering & Biotechnology News

Epigenetic drugs set to boost immunoncology – European Biotechnology

German oncologists have unveiled that market-approved inhibitors of DNA methyltransferases (DMNTi) and histone deacetylases (HDACi) act through expression of cancer neoantigens. They already have a biomarker test to identify responders.

The findings, reported in Nature Genetics, are good news for drug developers who want to broaden the scope of current immune checkpoint modulators through combination therapies that trigger cancer cells to release immunogenic neoantigens.

Following addition of epigenetic inhibitors to cancer cell cultures thousands of atypical transcripts with altered frameshift were expressed form previously ignored endogenous promotors of retroviral origin, resulting in profound tumour cell death, group leader Plass from German Cancer Centre told European Biotechnology. His team has already a biomarker assay that could identify responders to the treatment as it measures activation of the normally silent treatment induced, not-annotated transcription start sites (TINATs).

Up to now, pharma majors such as Roche/Genentech have largely relied on combination of their checkpoint inhibitors with personalised mRNA cancer vaccines. The new findings might open the avenue to a broader activation of cancer neoantigens than these vaccinesas over 2,500 TINATs have been identified in the human genome by the researchers. The retrotransposons (elements of human endogenous retroviruses, HERVs), which are located in long terminal repeats, have entered the human genome millions of years ago.

However, application of the findings might be hampered by the fact that TINATs, so far, have only been identified in the human genome, which might complicate preclinical in-vivo testing. Its unclear if they also exist in animals, says Plass, who is currently deciphering the exact mechanism that normally stops TINATs from being activated. First findings suggest that acetylation of transcription factors might play an important role.

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Epigenetic drugs set to boost immunoncology - European Biotechnology

Puma Biotechnology, Inc. (PBYI): What’s the Story? – StockNewsJournal


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Puma Biotechnology, Inc. (PBYI): What's the Story?
StockNewsJournal
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Puma Biotechnology, Inc. (PBYI): What's the Story? - StockNewsJournal

Peterborough biotechnology startup targeting $50 million in equity financing – Kawartha Media Group


Kawartha Media Group
Peterborough biotechnology startup targeting $50 million in equity financing
Kawartha Media Group
Peterborough biotechnology startup targeting $50 million in equity financing. Community Jun 22, 2017 02:20 by Todd Vandonk Peterborough This Week. Share. Noblegen Inc. CEO and founder Adam Noble and CCO and co-founder Dr. Andressa Lacerda ...
Noblegen Announces the Opening of Its Second Round of Financing: Peterborough-based biotechnology startup ...GlobeNewswire (press release)

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Peterborough biotechnology startup targeting $50 million in equity financing - Kawartha Media Group

Knight Cancer Institute nabs San Diego tech star – Portland Business Journal


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Knight Cancer Institute nabs San Diego tech star
Portland Business Journal
Oregon Health & Science University's Knight Cancer Institute is adding a technology expert to its growing team. Mike Heller, a specialist in bioengineering coming from the University of California, San Diego, will head technology efforts for the ...
Technology expert joins the OHSU Knight Cancer Institute's center for cancer early detectionPR Newswire (press release)

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GenX: A Question Of Chemistry – WHQR

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New Hanover County Commissioners adopted a resolution Monday calling on Chemours to stop production of GenX. Brunswick County Commissioners adopted a resolution the same day -- asking Chemours to stop the discharge of the GenX chemical into the Cape Fear River. Thats largely because there is still a lot about GenX that we dont know. Its all about chemistry. Which means for many of us, it can be somewhat difficult to grasp.

As a scientist, I rely on data, to inform my approaches, and my evaluations, and I dont have the data yet.

Dr. Susanne Brander is a toxicologist at UNC Wilmington.

She says to understand GenX, one needs to look at its predecessor.

And so the only way to have an idea of what could be expected from exposure to a chemical like that is to look at what is known about a similar chemical, and there has been a lot of talk about how GenX was the replacement for another chemical known as C8, also known as Perfluorooctanoic acid. A PFOA.

C8 is a confirmed carcinogen. Its been linked to a wide range of diseases and cancers. Thats why GenX was developed. C8 is a long chain of carbonfluorine bonds. In GenX chemists added an oxygen atom to the middle of the chain. The thinking was this would make the compound less persistent, and it would pass through the body more quickly.

Dr. Phillippe Grandjean is with the Harvard University School of Public Health, and also chair of Environmental Health at the University of Southern Denmark.

We know that they appear to have a short half-life meaning they are eliminated very rapidly. But the fact of the matter is yes they do leave the bloodstream, but that is because they are accumulated in the body, the liver the kidneys the lungs, and so just because some of them appear to disappear from the blood rapidly, that may not indicate that they have disappeared from the body as a whole.

He says GenX is easily absorbed.

So if you drink contaminated water these compounds will rapidly move into your bloodstream and be circulated so that they can reach all the organs of the body. We also know that these compounds can cause liver cancer, in rodents.

Its when the GenX molecule attaches to other cells, that health issues can arise, albeit years down the road. Dr. Larry Cahoon is with UNC Wilmington.

This is a molecule, GenX and its congeners, that is going to tend to bind to cell membranes including some of the receptors that normally would bind with the hormone molecules or some of the other signaling molecules.

And, Cahoon says, they are resilient.

These compounds dont break down. Biologically they are not broken down. Once they are loose in the environment, they are loose in the environment and thats it. You are not going to get rid of them, these compounds are persistent as they possibly could be.

Again, Dr. Grandjean.

So this is very parallel to what we knew about PFOA, C8, in the 1990s, and my concern is that if these new GenX compounds if they have properties, I would be concerned that there might be additional toxic effects.

The levels of GenX in the Cape Fear River remain a mystery. This week the states Department of Environmental Quality began a series of tests at 13 locations between the Chemours facility, and Wilmington. Those results should be available in a few weeks.

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GenX: A Question Of Chemistry - WHQR

Weike Wang Combines Humor, Science, and Depression in Debut Novel ‘Chemistry,’ – NBCNews.com

As for Wang herself, she said she genuinely enjoyed working in the sciences, but still felt her fate lay elsewhere. I like research, but I realized that someone else could be doing that research, with my writing I felt like I could be the only one doing that, she said.

In addition to the books humor, reviewers have noted Wangs choice to keep her narrator nameless. Wang explained that the decision to do so was a deliberate one. When I think of a name it is very specific to the character and I didnt want that to happen, Wang said. Would I name her something Chinese or something American? I didnt want to deal with that.

Juggling multiple identities is something Wang has a bit of experience in. Born in China, she and her family moved to Australia when she was 7 and later moved to Canada and then eventually to the United States. When I write characters that are not open, its because Im not necessarily that open in terms of opening up to new people, Wang said. I made her like that in that she is just very lonely. And when you are lonely, you are not used to telling people how you feel.

Wang added that she has been a bit taken aback at how mean many readers and reviewers said they thought her narrators parents were. Noting that while her books fictional parents did have high standards and did not always understand their daughter (especially as she waffled in regards to her studies), they were not uncaring.

When you are an immigrant parent, Do I want to make my child happy? is not a question you always ask, Wang said. Its I need to feed her. I need to put a roof over her head. I need to make sure she has health insurance. My point is not to vilify them.

That view of family also shaped how Wang developed her narrators journey and subsequent contrariness. Its not the traditional rebel story. Its not like Im going to go travel to find myself or I am going to join a band.' Because everyone I know rebels quietly, she said. Its not F**k you, parents. Im just going to leave the country.' Its doing really tiny things. Because first, my parents would kill me if I did that and also, how am I going to get health insurance if I do that?

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Weike Wang Combines Humor, Science, and Depression in Debut Novel 'Chemistry,' - NBCNews.com

Environmental Defense Fund: Sustainable farming, feeding growing population require biotechnology – Genetic Literacy Project

It is critical that humanity meet the food needs of a growing population and relieve the increasing pressures on natural systems. Environmental Defense Fund supports the coexistence of diverse farming systems to ensure a sustainable future for farmers, society, and our environment. Achieving these goals will require a comprehensive strategy that draws on a wide range of approaches and technologies, including biotechnology.

EDF recognizes the use of biotechnology as a legitimate deployment of science in the search for effective solutions, and also recognizes that past deployment of some biotechnology products has caused legitimate concerns. For that reason, we will support or oppose specific biotechnology products or processes based on transparent assessments of their health, environmental, social, and economic risks and benefits.The risks and benefits of biotechnology products will often vary by organism, geography and other variables, and need to be assessed at relevant temporal and spatial scales.

The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion, and analysis. Read full, original post:Our position on biotechnology

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Environmental Defense Fund: Sustainable farming, feeding growing population require biotechnology - Genetic Literacy Project

Anatomy of a Witch Hunt – Wall Street Journal (subscription)


Wall Street Journal (subscription)
Anatomy of a Witch Hunt
Wall Street Journal (subscription)
Americans won't be really good citizens until they read Timur Kuran and Cass Sunstein's 1999 law review article about availability cascades. Their launching point is the process by which we (i.e., human beings) decide to believe what others believe ...

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Anatomy of a Witch Hunt - Wall Street Journal (subscription)

World’s oldest super fruit delivers super anti-aging protection – Personal Liberty Digest

Goji berries are fairly new to the Western world, but theyve actually been around for more than 2,000 years. Legend claims they were favored by monks who lived high in the Himalayan mountains. Steeped in water, these miraculous berries were reputed to help in meditation and deliver health, energy, vitality and longevity to those who consumed them. Who doesnt want that?

The Chinese called them wolfberry fruit, and used them for their medicinal properties since around 200 B.C. Their benefits are detailed in the oldest known book on Chinese medicine, which records the medicinal knowledge and practices of the mythical Chinese emperor, Shen Nong.

The myriad of reputed attributes of goji berries have persisted through the centuries and withstood the scrutiny of science. We now know that goji berries which boast plenty of fiber, an abundance of antioxidants and more than 20 different vitamins and minerals can naturally treat all sorts of health concerns.

Goji berries are loaded with antioxidants, whose claim to fame is their ability to neutralize free radicals those un-neighborly molecules that, missing an ion, attack nearby molecules to steal one.

Of course, that leaves a robbed molecule with an uneven number of ions, turning it into another free radical and launching a frenzied, destructive chain reaction of molecule attacks.

Because free radical damage is a major cause of aging and disease, antioxidants are essential for good health and longevity. The goji berry is rich in health-promoting, antioxidant carotenoids: beta-carotene, lycopene, beta-cryptoxanthin, zeaxanthin and lutein.

The ORAC (Oxygen Radical Absorbance Capacity) table measures the antioxidant value of fruits and vegetables. The ORAC shows one ounce of goji berry juice has 10 times more free-radical destroying ability than most other fruits and vegetables. Comparatively, goji berries outstrip oranges for vitamin C, carrots for beta carotene and steak for iron. They have four times more potassium than bananas, and theyre loaded with vitamin C and zinc, both powerful health protectors.

The goji berrys ORAC score puts it in the same class as other superhero, super fruits such as Acai berries, Hawaiian Noni and Mangosteen.

Goji berries contain 18 amino acids, 21 trace minerals (zinc, iron, calcium selenium and phosphorus) and five unsaturated fatty acids (including linoleic and alpha-linolenic acids).

The antioxidants found in goji berries may protect you not only against free radicals but also against oxidative stress and inflammation (the damage free radicals cause). The vitamin C content of goji berries not only helps the common cold but helps wrinkled and sagging skin, cholesterol, blood flow, blood sugar plus, heart, cell and eye health.

Carotenoids convert to vitamin A, which boosts your immune system, eye health and helps build strong bones and teeth.

By preventing damage from UV light exposure and free radicals, the antioxidants zeaxanthin and lutein protect against age-related blindness.

The power of goji berry juice can protect your skin from free radical damage caused by sun exposure. It even provides photoprotection for those who are vulnerable to developing diseases of the skin.

Combined with a healthy diet, goji berries provide a natural approach to blood sugar by helping insulin. For people with blood sugar concerns, dried goji berries provide a preferable snack alternative to high-sugar processed foods.

Goji berries also improve liver and kidney detoxification, energy levels and fertility.

Want more? This super fruit can help support weight loss, boost energy levels, increase your resistance to fatigue, improve focus, strengthen your immune system and enhance sleep quality.

The next time you want a snack, pass on the potato chips and give your body a bonanza of health benefits by choosing dried goji berries. Or get your antioxidant boost every day by taking a high-quality supplement like Peak ResV+ Superfruits. It contains, not only Goji berry but Resveratrol, Acai, Hawaiian Noni, Mangosteen and six other super fruit, superheroes.

Sources: Axe, J. Goji Berry Benefits: Antioxidant & Anti-Inflammatory Superfruit. Dr.Axe.com. draxe.com/ goji-berry-benefits.

Benefits of Goji Berries: The Chinese Longevity Fruit. Antioxidants-for-Health-and-Longevity. antioxidants-for-health-and-longevity.com/benefits-of-goji-berries.html.

Chinese Wolfberry Benefits & Doses. SFGate. healthyeating.sfgate.com/chinese-wolfberry-benefits-doses-8671.html.

Rupavate, S. 15 ways Vitamin C keeps you healthy and fit! The Health Site. thehealthsite.com/fitness/health-benefits-of-vitamin-c-sh214/. Aug. 3, 2015

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World's oldest super fruit delivers super anti-aging protection - Personal Liberty Digest