Toys"R"Us®, Canada helps "Shine A Light For Autism" during third annual fundraising campaign to benefit Autism Speaks …

Campaign Focuses On How Families Can "Light It Up Blue" To Raise Autism Awareness Across Canada

TORONTO, March 1, 2012 /CNW/ - Toys"R"Us, Canada today announced the launch of its in-store and online fundraising campaign to benefit Autism Speaks, North America's largest autism science and advocacy organization. Now through Monday, April 30, Toys"R"Us and Babies"R"Us stores will offer customers an Autism Speaks puzzle piece in exchange for a $1 donation. Monetary donations will be collected at all 73 stores (including Express locations) across the country and online at Toysrus.ca. The company is heightening its focus on autism awareness, unveiling a new theme for the 2012 campaign, "Shine A Light For Autism."

"With so many children affected by autism and not enough known about causes or cures, we hope that our fundraising and awareness campaigns can contribute to solving the autism puzzle," said Kevin Macnab, President, Toys"R"Us Canada. "Through our ongoing partnership, the "R"Us family remains committed to helping Autism Speaks and the critical work they do in supporting families affected by autism spectrum disorders."

Shining A Light For Autism In-store and online

During the campaign, customers can contribute a cash donation at all Toys"R"Us and Babies"R"Us locations, including Express locations, and online at Toysrus.ca.

In-store signage displayed in Toys"R"Us and Babies"R"Us stores across the country feature children with autism dressed as super-heroes, with the Autism Speaks puzzle piece logo as their powerful emblem. The puzzle pieces are bursting with light, while inspiring everyone to donate to the cause by looking to the hero within.

"Toys"R"Us and Babies"R"Us stores across Canada are in a unique position to reach numerous parents daily, providing important awareness information about autism in their stores, as well as online," said Suzanne Lanthier, Executive Director of Autism Speaks Canada. "We are thrilled to bring hope to families who live with the realities of autism every day, through ongoing support in our research and advocacy efforts."

Toysrus.ca also serves as a resource for parents, caregivers, families and friends of children with autism. Visitors can find a list of "Ten Toys That Speak To Autism," which provides toy suggestions to help guide anyone purchasing toys for a child with autism.

Walking To Benefit Autism Speaks

In conjunction with the campaign, the company is also kicking off its national sponsorship of Walk Now for Autism Speaks, a year-long series of more than 85 walk events taking place throughout North America. Toys"R"Us and Babies"R"Us employees will walk alongside the company's iconic mascot, Geoffrey the Giraffe, as well as individuals with autism, their families and friends to raise money and awareness for the cause. All funds raised through the Walk Now for Autism Speaks events will go directly to Autism Speaks to support research awareness and family services programs in Canada.

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Toys"R"Us®, Canada helps "Shine A Light For Autism" during third annual fundraising campaign to benefit Autism Speaks ...

Toys”R”Us®, Canada helps “Shine A Light For Autism” during third annual fundraising campaign to benefit Autism Speaks …

Campaign Focuses On How Families Can "Light It Up Blue" To Raise Autism Awareness Across Canada

TORONTO, March 1, 2012 /CNW/ - Toys"R"Us, Canada today announced the launch of its in-store and online fundraising campaign to benefit Autism Speaks, North America's largest autism science and advocacy organization. Now through Monday, April 30, Toys"R"Us and Babies"R"Us stores will offer customers an Autism Speaks puzzle piece in exchange for a $1 donation. Monetary donations will be collected at all 73 stores (including Express locations) across the country and online at Toysrus.ca. The company is heightening its focus on autism awareness, unveiling a new theme for the 2012 campaign, "Shine A Light For Autism."

"With so many children affected by autism and not enough known about causes or cures, we hope that our fundraising and awareness campaigns can contribute to solving the autism puzzle," said Kevin Macnab, President, Toys"R"Us Canada. "Through our ongoing partnership, the "R"Us family remains committed to helping Autism Speaks and the critical work they do in supporting families affected by autism spectrum disorders."

Shining A Light For Autism In-store and online

During the campaign, customers can contribute a cash donation at all Toys"R"Us and Babies"R"Us locations, including Express locations, and online at Toysrus.ca.

In-store signage displayed in Toys"R"Us and Babies"R"Us stores across the country feature children with autism dressed as super-heroes, with the Autism Speaks puzzle piece logo as their powerful emblem. The puzzle pieces are bursting with light, while inspiring everyone to donate to the cause by looking to the hero within.

"Toys"R"Us and Babies"R"Us stores across Canada are in a unique position to reach numerous parents daily, providing important awareness information about autism in their stores, as well as online," said Suzanne Lanthier, Executive Director of Autism Speaks Canada. "We are thrilled to bring hope to families who live with the realities of autism every day, through ongoing support in our research and advocacy efforts."

Toysrus.ca also serves as a resource for parents, caregivers, families and friends of children with autism. Visitors can find a list of "Ten Toys That Speak To Autism," which provides toy suggestions to help guide anyone purchasing toys for a child with autism.

Walking To Benefit Autism Speaks

In conjunction with the campaign, the company is also kicking off its national sponsorship of Walk Now for Autism Speaks, a year-long series of more than 85 walk events taking place throughout North America. Toys"R"Us and Babies"R"Us employees will walk alongside the company's iconic mascot, Geoffrey the Giraffe, as well as individuals with autism, their families and friends to raise money and awareness for the cause. All funds raised through the Walk Now for Autism Speaks events will go directly to Autism Speaks to support research awareness and family services programs in Canada.

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Toys"R"Us®, Canada helps "Shine A Light For Autism" during third annual fundraising campaign to benefit Autism Speaks ...

Autism Is Jim Calhoun's Biggest Opponent

Jim Calhoun, like many coaches, is superstitious. He might have a lucky tie or piece of jewelry he must wear to end a losing streak, or keep a winning streak going.

But one item that remains in good times and bad is the blue puzzle piece he wears on the lapel of his suit jacket. The symbol for Autism Speaks, like the cause itself, remains close to his heart at all times.

"He has never taken it off," Jeff Calhoun said. "I can't tell you how many people who have mentioned it to me parents, families touched by autism, who tell me how much it means to them. He is very passionate about it. Just by lending his name and reaching out to people, he has done more than we could ever ask."

Said Amy Calhoun: "When I see that blue pin on his lapel, it sometimes brings tears to my eyes. He is taking this on for Reese."

The cause is a personal one for the Calhoun family. Jeff and Amy's daughter, Reese, now 8, was diagnosed at 2, and her grandfather's involvement with the advocacy group Autism Speaks is very deep.

But because he is scheduled to undergo back surgery on Monday in New York, Calhoun will not be able to participate in an event he has helped launch "CardioRaiser: Workout for Autism Speaks" at Cardio Express in Manchester and Southington from 9 a.m. to 3 p.m. on Sunday. Farmington Bank is the presenting sponsor.

"It's just so important to raise awareness," Jeff Calhoun said, "because autism, anything that involves the brain, is something we don't talk about much as a society. We want to share our story, and hope it lets people know they are not alone."

Hundreds are expected to participate, and the event is expected to raise at least $100,000 for the Connecticut chapter of Autism Speaks. Participants may choose from a variety of exercise activities to help in the cause. Although Jim Calhoun cannot be there, some of his assistants are expected to stop by the morning after UConn plays Syracuse (Saturday night at 9 p.m.). Panera Bread will provide breakfast for participants.

The event will become an annual one, Jeff Calhoun said.

"I am deeply committed to the cause of helping families confronting the many challenges of autism," Jim Calhoun said in January, when the event was scheduled. "It is my hope that this event will bring Connecticut families together to raise dollars so important to all those facing this complex neurobiological disorder."

See the original post here:
Autism Is Jim Calhoun's Biggest Opponent

Autism Is Jim Calhoun’s Biggest Opponent

Jim Calhoun, like many coaches, is superstitious. He might have a lucky tie or piece of jewelry he must wear to end a losing streak, or keep a winning streak going.

But one item that remains in good times and bad is the blue puzzle piece he wears on the lapel of his suit jacket. The symbol for Autism Speaks, like the cause itself, remains close to his heart at all times.

"He has never taken it off," Jeff Calhoun said. "I can't tell you how many people who have mentioned it to me parents, families touched by autism, who tell me how much it means to them. He is very passionate about it. Just by lending his name and reaching out to people, he has done more than we could ever ask."

Said Amy Calhoun: "When I see that blue pin on his lapel, it sometimes brings tears to my eyes. He is taking this on for Reese."

The cause is a personal one for the Calhoun family. Jeff and Amy's daughter, Reese, now 8, was diagnosed at 2, and her grandfather's involvement with the advocacy group Autism Speaks is very deep.

But because he is scheduled to undergo back surgery on Monday in New York, Calhoun will not be able to participate in an event he has helped launch "CardioRaiser: Workout for Autism Speaks" at Cardio Express in Manchester and Southington from 9 a.m. to 3 p.m. on Sunday. Farmington Bank is the presenting sponsor.

"It's just so important to raise awareness," Jeff Calhoun said, "because autism, anything that involves the brain, is something we don't talk about much as a society. We want to share our story, and hope it lets people know they are not alone."

Hundreds are expected to participate, and the event is expected to raise at least $100,000 for the Connecticut chapter of Autism Speaks. Participants may choose from a variety of exercise activities to help in the cause. Although Jim Calhoun cannot be there, some of his assistants are expected to stop by the morning after UConn plays Syracuse (Saturday night at 9 p.m.). Panera Bread will provide breakfast for participants.

The event will become an annual one, Jeff Calhoun said.

"I am deeply committed to the cause of helping families confronting the many challenges of autism," Jim Calhoun said in January, when the event was scheduled. "It is my hope that this event will bring Connecticut families together to raise dollars so important to all those facing this complex neurobiological disorder."

See the original post here:
Autism Is Jim Calhoun's Biggest Opponent

Autism groups to merge

The local nonprofit groups Life Skills for adults with developmental disabilities and TouchPoint Autism Services will merge their organizations as of July 1 to support a growing number of adults with autism.

The new organization will be known as Life Skills, and TouchPoint (formerly the Judevine Center for Autism) will still be used to refer to autism services.

"As these children who are diagnosed with autism are aging, we really wanted to be prepared to meet that need," said Wendy Sullivan, CEO of the new organization.

Parents can be "confident you can stay with this organization through the child's lifetime," Sullivan said.

Life Skills provides 24-hour assistance including in-home care, job training and placement to teenagers and adults with Down syndrome, cerebral palsy, autism and other developmental disabilities. TouchPoint Autism Services offers early intervention services, behavior therapy, parent training and employment services through seven offices in Missouri. Both groups, which have offices in west St. Louis County, are United Way member agencies.

The organization will have a combined 1,200 employees. There are no immediate plans for layoffs or eliminating positions, Sullivan said.

Read more here:
Autism groups to merge

Redefining Autism: Proposal Worries Many Parents

When Caleb Geary was diagnosed with autism at age 3, he had never spoken or eaten solid food.

Now 6, the boy speaks and tests at his first-grade level progress that his parents attribute to insurance-based services at home and intensive behavioral intervention at the boy's school in Hamden.

But they worry what will happen to Caleb's diagnosis and the services that have come with it if the American Psychiatry Association's proposal to change the definition of autism is adopted.

Lori Geary said she has already fought to get her son the help he needs. Tom Zwicker, Caleb's father and the director of an autism center for the Easter Seals of Coastal Fairfield County, said he believes insurance companies will start requesting annual diagnostic evaluations if the definition is revised. As a result, his son and many other children will lose out on services to treat their conditions.

"You have an entire group receiving services that would be left out in the cold," said Zwicker, who lives in Branford. "We're going to lose a whole generation of children."

The autism community has been embroiled in a heated debate for the past few weeks over the proposal to dramatically change the criteria for autism diagnosis in the upcoming fifth edition of the Diagnostic and Statistical Manual of Mental Disorders. The DSM-5, scheduled to be published in 2013, is the first revision since 1994.

The revision would create an umbrella category known as "autism spectrum disorder" that would include traditional autism, as well as Asperger's Syndrome, childhood disintegrative disorder and pervasive developmental disorder not otherwise specified (PDD-NOS) which currently are considered separate disorders. A new category, social communication disorder, would also be created.

"What became very apparent is that there aren't clear boundaries, and that they really are all on a spectrum," said Darrell Regier, director of research for the APA. The current criteria, he said, is "fuzzy" and as a result some people have been mislabeled as autistic, while others who need treatment can't get it because their symptoms don't match the current criteria.

"The thing that we tried to do is be a little more clear about the different deficits that these people have," Regier said.

But some experts worry that the revision's main effect will be to drastically reduce the number of people who are diagnosed with autism and who now qualify for services to treat it.

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Redefining Autism: Proposal Worries Many Parents

'Parent Training' May Help Kids With Autism Behave Better

THURSDAY, March 1 (HealthDay News) -- Children with autism often display challenging behaviors, but new research suggests that parents can learn to better handle tantrums and aggression, which may improve their child's overall functioning.

"Parent training is one of the best, evidence-supported treatment interventions in child psychiatry for other conditions, such as for children with ADHD or children with oppositional defiant disorder," said senior study author Lawrence Scahill, a professor at Yale University School of Nursing and Child Study Center in New Haven, Conn. "But strangely enough, it had never really been tried with children with autism or with developmental disabilities, so we had to make our own manual."

The study involved 124 children aged 4 to 13 with an autism spectrum disorder and serious behavioral issues, including daily, prolonged tantrums, aggression or self-injurious behavior. The children were prescribed risperidone (Risperdal), an antipsychotic drug approved by the U.S. Food and Drug Administration for treating severe behavioral problems in children with autism.

Half the children and their parents were also assigned to a six-month, structured "parent training" program. Parents were asked to identify the most difficult, disruptive behaviors and to think about what preceded the incidents and why the child might do it. They then worked with counselors to devise strategies to avoid the triggers and help the child respond better to the everyday stressors.

Parents who underwent training reported a greater decrease in problem behaviors than the parents of children on medication alone, researchers found. By the end of the study, the average dose of risperidone was lower for kids in the parent-training group.

"On the tantrums, the aggression and the self-injury, the combination of medications and parent training was better," said Scahill. "How much better? Not a huge amount, but it was an incremental improvement over an already effective improvement."

Parents who received training also reported improvements on a test known as the Vineland Adaptive Behavior Scale, which measures how well a child does everyday activities, such as communicating, socializing, dressing, eating at the table and going to school.

By diminishing serious problem behaviors, such as tantrums and aggression, children's skills in other areas improved, but the difference was not statistically significant.

Autism is a neurodevelopmental disorder characterized by impaired social interaction, verbal and nonverbal communication, restricted interests and behaviors, repetitive behaviors and sometimes intellectual disability.

The study is published in the February issue of the Journal of the American Academy of Child & Adolescent Psychiatry.

View post:
'Parent Training' May Help Kids With Autism Behave Better

‘Parent Training’ May Help Kids With Autism Behave Better

THURSDAY, March 1 (HealthDay News) -- Children with autism often display challenging behaviors, but new research suggests that parents can learn to better handle tantrums and aggression, which may improve their child's overall functioning.

"Parent training is one of the best, evidence-supported treatment interventions in child psychiatry for other conditions, such as for children with ADHD or children with oppositional defiant disorder," said senior study author Lawrence Scahill, a professor at Yale University School of Nursing and Child Study Center in New Haven, Conn. "But strangely enough, it had never really been tried with children with autism or with developmental disabilities, so we had to make our own manual."

The study involved 124 children aged 4 to 13 with an autism spectrum disorder and serious behavioral issues, including daily, prolonged tantrums, aggression or self-injurious behavior. The children were prescribed risperidone (Risperdal), an antipsychotic drug approved by the U.S. Food and Drug Administration for treating severe behavioral problems in children with autism.

Half the children and their parents were also assigned to a six-month, structured "parent training" program. Parents were asked to identify the most difficult, disruptive behaviors and to think about what preceded the incidents and why the child might do it. They then worked with counselors to devise strategies to avoid the triggers and help the child respond better to the everyday stressors.

Parents who underwent training reported a greater decrease in problem behaviors than the parents of children on medication alone, researchers found. By the end of the study, the average dose of risperidone was lower for kids in the parent-training group.

"On the tantrums, the aggression and the self-injury, the combination of medications and parent training was better," said Scahill. "How much better? Not a huge amount, but it was an incremental improvement over an already effective improvement."

Parents who received training also reported improvements on a test known as the Vineland Adaptive Behavior Scale, which measures how well a child does everyday activities, such as communicating, socializing, dressing, eating at the table and going to school.

By diminishing serious problem behaviors, such as tantrums and aggression, children's skills in other areas improved, but the difference was not statistically significant.

Autism is a neurodevelopmental disorder characterized by impaired social interaction, verbal and nonverbal communication, restricted interests and behaviors, repetitive behaviors and sometimes intellectual disability.

The study is published in the February issue of the Journal of the American Academy of Child & Adolescent Psychiatry.

View post:
'Parent Training' May Help Kids With Autism Behave Better

:: 01, Mar 2012 :: A*STAR SCIENTISTS MAKE GROUNDBREAKING DISCOVERY ON STEM CELL REGULATION

MEDIA RELEASE

A*STAR Scientists Make Groundbreaking Discovery on Stem Cell Regulation

New link between polyamine levels and embryonic stem cell state deepens our understanding of embryonic stem cell regulation which is a key step in bringing cellular therapies from the laboratory to the clinic.

1. A*STAR scientists have for the first time, identified that precise regulation of polyamine[1] levels is critical for embryonic stem cell (ESC) self-renewal the ability of ESCs to divide indefinitely and directed differentiation. This paper is crucial for better understanding of ESC regulation and was published in the journal Genes & Development on 1st March by the team of scientists from the Institute of Medical Biology (IMB), a research institute under the Agency for Science, Technology and Research (A*STAR).

2. Embryonic stem cells hold great potential for the development of cellular therapies, where stem cells are used to repair tissue damaged by disease or trauma. This is due to their unique ability to renew themselves and differentiate into any specific types of cell in the body. One of the challenges with cellular therapies is ensuring that ESCs are fully and efficiently differentiated into the correct cell type. This study sheds light on understanding how ESCs are regulated, which is essential to overcome these challenges and turn the vision of cell therapies into reality.

3. Using a mouse model, the team of scientists from IMB showed that high levels of Amd1[2], a key enzyme in the polyamine synthesis pathway, is essential for maintenance of the ESC state and self renewal of ESCs. To further demonstrate the critical role of Amd1 in ESC self-renewal, the scientists showed that increasing Amd1 levels led to delayed ESC differentiation. The research also revealed that downregulation of Amd1 was necessary for differentiation of ESCs into neural precursor cells and that Amd1 is translationally regulated by a micro-RNA (miRNA), the first ever demonstration of miRNA-mediated regulation of the polyamine pathway.

4. While the polyamine pathway is well established and polyamines are known to be important in cancer and cell proliferation, their role in ESC regulation until now was unknown. This novel discovery, linking polyamine regulation to ESC biology, came about when the team set up a genome-wide screen to look for mRNAs under translational control in order to identify new regulators of ESC differentiation to neural precursor cells.

6. Dr Leah Vardy, Principle Investigator at the IMB and lead author of the paper, said, The polyamines that Amd1 regulate have the potential to regulate many different aspects of self renewal and differentiation. The next step is to understand in more detail the molecular targets of these polyamines both in embryonic stem cells and cells differentiating to different cellular lineages. It is possible that manipulation of polyamine levels in embryonic stem cells through inhibitors or activators of the pathway could help direct the differentiation of embryonic stem cells to more clinically useful cell types.

7. Prof. Birgitte Lane, Executive Director of IMB, said, This is a fine piece of fundamental research that will have breakthrough consequences in many areas and can bring about far-reaching applications. Developing cellular therapies is just one long-term clinical benefit of understanding ESC biology, which can also help develop stem cell systems for disease modeling, developing new drugs as well as a tool for researchers to answer other biological questions.

Notes for editor:

See original here:
:: 01, Mar 2012 :: A*STAR SCIENTISTS MAKE GROUNDBREAKING DISCOVERY ON STEM CELL REGULATION

A*STAR Scientists Make Groundbreaking Discovery on Stem Cell Regulation

Embryonic stem cells hold great potential for the development of cellular therapies, where stem cells are used to repair tissue damaged by disease or trauma. This is due to their unique ability to renew themselves and differentiate into any specific types of cell in the body. One of the challenges with cellular therapies is ensuring that ESCs are fully and efficiently differentiated into the correct cell type. This study sheds light on understanding how ESCs are regulated, which is essential to overcome these challenges and turn the vision of cell therapies into reality.

Using a mouse model, the team of scientists from IMB showed that high levels of Amd1 , a key enzyme in the polyamine synthesis pathway, is essential for maintenance of the ESC state and self renewal of ESCs. To further demonstrate the critical role of Amd1 in ESC self-renewal, the scientists showed that increasing Amd1 levels led to delayed ESC differentiation. The research also revealed that downregulation of Amd1 was necessary for differentiation of ESCs into neural precursor cells and that Amd1 is translationally regulated by a micro-RNA (miRNA), the first ever demonstration of miRNA-mediated regulation of the polyamine pathway.

While the polyamine pathway is well established and polyamines are known to be important in cancer and cell proliferation, their role in ESC regulation until now was unknown. This novel discovery, linking polyamine regulation to ESC biology, came about when the team set up a genome-wide screen to look for mRNAs under translational control in order to identify new regulators of ESC differentiation to neural precursor cells.

Dr Leah Vardy, Principle Investigator at the IMB and lead author of the paper, said, "The polyamines that Amd1 regulate have the potential to regulate many different aspects of self renewal and differentiation. The next step is to understand in more detail the molecular targets of these polyamines both in embryonic stem cells and cells differentiating to different cellular lineages. It is possible that manipulation of polyamine levels in embryonic stem cells through inhibitors or activators of the pathway could help direct the differentiation of embryonic stem cells to more clinically useful cell types."

Prof. Birgitte Lane, Executive Director of IMB, said, "This is a fine piece of fundamental research that will have breakthrough consequences in many areas and can bring about far-reaching applications. Developing cellular therapies is just one long-term clinical benefit of understanding ESC biology, which can also help develop stem cell systems for disease modeling, developing new drugs as well as a tool for researchers to answer other biological questions."

Notes for editors: The research findings can be found in the 1st March issue of Genes and Development under the title, "AMD1 is essential for ESC self-renewal and is translationally down-regulated on differentiation to neural precursor cells" by Dawei Zhang (1,4), Tianyun Zhao (1,4), Haw Siang Ang (2), Peini Chong (1), Ryotaro Saiki (3), Kazuei Igarashi (3), Henry Yang (2), and Leah A. Vardy (1,5).

1. Institute of Medical Biology, A*STAR, Singapore 2. Cancer Science Institute, National University of Singapore 3. Graduate School of Pharmaceutical Sciences, Chiba University, Japan 4. These authors contributed equally to this work 5. Corresponding author

About the Institute of Medical Biology (IMB)

IMB is one of the Biomedical Sciences Institutes of the Agency for Science, Technology and Research (A*STAR). It was formed in 2007, the 7th and youngest of the BMRC Research Institutes, with a mission to study mechanisms of human disease in order to discover new and effective therapeutic strategies for improved quality of life.

IMB hosts 20 research teams of international excellence in stem cells, genetic diseases, cancer and skin and epithelial biology, and works closely with clinical collaborators to target the challenging interface between basic science and clinical medicine. Its growing portfolio of strategic research topics is targeted at translational research on the mechanisms of human diseases, with a cell-to-tissue emphasis that can help identify new therapeutic strategies for disease amelioration, cure and eradication.

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A*STAR Scientists Make Groundbreaking Discovery on Stem Cell Regulation

Stem cell study ‘should aim at innovation in treatment’

By Bonnie James Deputy News Editor The stem cell and regenerative therapy programme, constituting a major part of research at Qatar Cardiovascular Research Centre (QCRC), has important clinical and scientific implications, co-chairman Prof Sir Magdi Yacoub has said. He was giving a keynote presentation at the Qatar International Conference on Stem Cell Science and Policy 2012, which concluded on Thursday at Qatar National Convention Centre. Myocardium (the muscular tissue of the heart) regeneration and tissue engineering and valves tissue engineering are among the focal areas at QCRC, which aims to establish in Qatar an internationally competitive centre of excellence for cardio-vascular research. QCRC, which has a heart muscle lab and a tissue engineering, regeneration lab, works with a mission to maintain a translational focus, relevant to the development of health policy and practice, and provide opportunities for capacity building, professional development and research collaborations in Qatar. It is also meant to provide opportunities for biotechnology development in Qatar and contribute to cardio-vascular health in the developing world through improved knowledge base, capacity building and development of appropriate tools and strategies focused on poorer countries. Cardio-vascular diseases (CVDs) kill 17mn people per year globally and there is particularly high incidence in the Middle East and Gulf region, Prof Yacoub pointed out. The incidence of CVDs is three times more in the region than in the UK, the US or Europe. Smoking, one of the main reasons for CVDs, is also increasing in the eastern Mediterranean region compared to the Americas. There is a significant lack of clinical, epidemiological and genetic data from this region and an overwhelming need exists to better understand epidemiology and disease mechanisms of CVDs. Research should then be linked to development of appropriate tools and strategies to strengthen prevention, diagnosis and treatment, he said. Pointing out that heart transplant options for those suffering from severe heart failure are becoming increasingly rare, Prof Yacoub observed that the number of donor hearts is going down globally. While we used to do up to 130 heart transplants a year at Royal Brompton and Harefield Hospitals in the UK in the late 80s, now we would be lucky to do 20, he said while emphasising the need to focus more on the reversibility of heart failure. Few recent drug trials have shown evidence of minor reverse remodelling and there have been near-complete reversal of almost every change in myocardium in some patients. There are unprecedented opportunities to unravel the secrets of heart failure at cellular and molecular levels, he stressed.

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Stem cell study ‘should aim at innovation in treatment’

Longmont a select city for creative Parkinson's disease dance class

LONGMONT -- Shake tambourines. Dance like a gypsy.

Now do it when you are struggling with Parkinson's disease, a progressive neurological disorder that can cause tremors, sluggishness and rigidity.

That's what Stephen Straub asks of his students every Wednesday afternoon during the "Movin' with Parkinson's" class at the Longmont Dance Theatre.

Where: Longmont Dance Theatre, 1422 Nelson Road, Longmont

When: 1 to 2 p.m. Wednesdays

Cost: $5

To register: Call 303-830-1839 or email Info@ParkinsonRockies.org.

More information: Visit ParkinsonRockies.org

Two years ago, Straub traveled to Brooklyn, N.Y., to take a two-day training program called Dance for PD at the Mark Morris Dance Group. The National Parkinson Foundation commissioned renown ballet choreographer Morris to use dance to engage Parkinson's patients.

Only 40 communities worldwide offer the class made available in Longmont last fall, said Kari Buchanan, spokeswoman for Denver-based Parkinson Association of the Rockies.

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Longmont a select city for creative Parkinson's disease dance class

Longmont a select city for creative Parkinson’s disease dance class

LONGMONT -- Shake tambourines. Dance like a gypsy.

Now do it when you are struggling with Parkinson's disease, a progressive neurological disorder that can cause tremors, sluggishness and rigidity.

That's what Stephen Straub asks of his students every Wednesday afternoon during the "Movin' with Parkinson's" class at the Longmont Dance Theatre.

Where: Longmont Dance Theatre, 1422 Nelson Road, Longmont

When: 1 to 2 p.m. Wednesdays

Cost: $5

To register: Call 303-830-1839 or email Info@ParkinsonRockies.org.

More information: Visit ParkinsonRockies.org

Two years ago, Straub traveled to Brooklyn, N.Y., to take a two-day training program called Dance for PD at the Mark Morris Dance Group. The National Parkinson Foundation commissioned renown ballet choreographer Morris to use dance to engage Parkinson's patients.

Only 40 communities worldwide offer the class made available in Longmont last fall, said Kari Buchanan, spokeswoman for Denver-based Parkinson Association of the Rockies.

Read the original:
Longmont a select city for creative Parkinson's disease dance class

Jeff Simpson has Multiple Sclerosis – Video

24-02-2012 09:58 Jeff is having to wait without the supports he is entitled to receive, because the state of Kansas doesn't want to provide the services he is entitled to use. Others in the state are getting services. While more than 3400 people are forced to wait. At this point people are waiting over 3 years for services. several have died with out the supports they need.

Read more here:
Jeff Simpson has Multiple Sclerosis - Video

Multiple sclerosis won't slow down Hilton Head woman

Ashley Carson was among the top 3,000 finishers out of the 5,000 in Savannah's Rock 'N' Roll Marathon in November.

Earlier this month, the 28-year-old trimmed her time to less than an hour in the Tybee Run Fest 10K. She also ran in the Jingle Bell 5K in 2009 and the Hilton Head Island half marathon in February 2011.

Carson's accomplishments as a runner aren't record breaking, but they are significant for someone who has been fighting multiple sclerosis since 2005.

"Some days I can run a marathon and others I do good just to get out of bed," Carson said.

Carson, a Hilton Head Island resident, is training for the three-day, 50-mile Challenge Walk MS: Charleston Challenge, which raises money for the National Multiple Sclerosis Society. MS is an unpredictable, often disabling disease of the central nervous system for which there is no cure yet. The 2012 event is March 2-4 from historic Charleston to the Isle of Palms.

She started running just before her senior year of college to lose weight. "While running I started noticing some weird things going on with my body," Carson recalled. "When I bent my neck to look down to tie my shoe, I felt an electrical shock from my spine into my leg and a lot of numbness and tingling. I felt like I was going to fall."

It continued with what she describes as a sensation of fireworks in her body. "My symptoms started with the tingling," Carson said. "And there was weakness and very minor balance issues. I had achy leg pain and fatigue, which are very common factors with MS, and I deal with this on a daily basis."

Her official diagnosis came the day before she began her senior year, studying athletic training at Lees-McCrae College in Banner Elk, N.C.

The diagnosis didn't stop her from 2 1/2 more years to obtain her graduate degree in occupational therapy.

Today, she is inspired by her patients. She is an occupational therapist at Coastal Carolina Hospital, where she works with adults, and at the Hilton Pediatric Rehab Outpatient clinics on Hilton Head and in Bluffton, where she works with children.

See original here:
Multiple sclerosis won't slow down Hilton Head woman

Multiple sclerosis won’t slow down Hilton Head woman

Ashley Carson was among the top 3,000 finishers out of the 5,000 in Savannah's Rock 'N' Roll Marathon in November.

Earlier this month, the 28-year-old trimmed her time to less than an hour in the Tybee Run Fest 10K. She also ran in the Jingle Bell 5K in 2009 and the Hilton Head Island half marathon in February 2011.

Carson's accomplishments as a runner aren't record breaking, but they are significant for someone who has been fighting multiple sclerosis since 2005.

"Some days I can run a marathon and others I do good just to get out of bed," Carson said.

Carson, a Hilton Head Island resident, is training for the three-day, 50-mile Challenge Walk MS: Charleston Challenge, which raises money for the National Multiple Sclerosis Society. MS is an unpredictable, often disabling disease of the central nervous system for which there is no cure yet. The 2012 event is March 2-4 from historic Charleston to the Isle of Palms.

She started running just before her senior year of college to lose weight. "While running I started noticing some weird things going on with my body," Carson recalled. "When I bent my neck to look down to tie my shoe, I felt an electrical shock from my spine into my leg and a lot of numbness and tingling. I felt like I was going to fall."

It continued with what she describes as a sensation of fireworks in her body. "My symptoms started with the tingling," Carson said. "And there was weakness and very minor balance issues. I had achy leg pain and fatigue, which are very common factors with MS, and I deal with this on a daily basis."

Her official diagnosis came the day before she began her senior year, studying athletic training at Lees-McCrae College in Banner Elk, N.C.

The diagnosis didn't stop her from 2 1/2 more years to obtain her graduate degree in occupational therapy.

Today, she is inspired by her patients. She is an occupational therapist at Coastal Carolina Hospital, where she works with adults, and at the Hilton Pediatric Rehab Outpatient clinics on Hilton Head and in Bluffton, where she works with children.

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Multiple sclerosis won't slow down Hilton Head woman

Biogen Idec Submits Application to FDA for Approval of Oral BG-12 to Treat Multiple Sclerosis

WESTON, Mass.--(BUSINESS WIRE)--

Today Biogen Idec (NASDAQ: BIIB - News) announced the company has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for marketing approval of BG-12 (dimethyl fumarate), the companys oral therapeutic candidate for the treatment of multiple sclerosis (MS). The regulatory submission was based on BG-12s comprehensive development program, in which BG-12 demonstrated significant reductions in MS disease activity coupled with favorable safety and tolerability in the Phase 3 DEFINE and CONFIRM studies.

While there have been important therapeutic advances in MS over the last 15 years, there is still a significant unmet need for new and innovative therapies that target the disease in different ways, said Douglas E. Williams, Ph.D., Biogen Idecs executive vice president of Research and Development. Based on the robust clinical efficacy and safety data seen in our Phase 3 studies, we believe BG-12 has the potential to become an important oral treatment option for MS patients.

Biogen Idec plans to submit a Marketing Authorisation Application (MAA) for BG-12 to the European Medicines Agency (EMA) within the coming days.

The rapid submissions of our BG-12 regulatory packages, which integrated one of the largest placebo-controlled data sets for a filing in MS, reflect our commitment to bringing additional therapies to patients in need as quickly as possible, concluded Dr. Williams. We anticipate hearing from regulatory authorities regarding the status and acceptance of our submissions within the next couple of months.

About BG-12

BG-12 (dimethyl fumarate) is an investigational oral therapy in late-stage clinical development for the treatment of relapsing-remitting multiple sclerosis (RRMS), the most common form of MS. BG-12 is the only currently known investigational compound for the treatment of RRMS that has experimentally demonstrated activation of the Nrf-2 pathway. In 2011, Biogen Idec announced positive data from DEFINE and CONFIRM, two global, placebo-controlled Phase 3 clinical trials that evaluated 240 mg of BG-12, administered either twice a day or three times a day, for two years.

AboutBiogen Idec

Through cutting-edge science and medicine,Biogen Idecdiscovers, develops and delivers to patients worldwide innovative therapies for the treatment of neurodegenerative diseases, hemophilia and autoimmune disorders. Founded in 1978,Biogen Idecis the worlds oldest independent biotechnology company. Patients worldwide benefit from its leading multiple sclerosis therapies, and the company generates more than$5 billionin annual revenues. For product labeling, press releases and additional information about the company, please visit http://www.biogenidec.com.

Safe Harbor

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Biogen Idec Submits Application to FDA for Approval of Oral BG-12 to Treat Multiple Sclerosis

Leann Reynolds: Multiple Sclerosis and Caregiving

Multiple sclerosis is a progressive disease that affects every individual uniquely, and therefore carries just as unique caregiving responsibilities for their loved ones.

Certainly people newly diagnosed with M.S. or who are in remission have very light needs of caregivers, whether those people are a spouse, adult children, or other family or friends. But if the disease is advanced, the caregiving load can be full-time.

Multiple sclerosis is a chronic and often disabling disease that affects the body's central nervous system.

The National Multiple Sclerosis Society has a free downloadable guide for caregivers that provides tips on how to care for themselves, how to manage severe physical symptoms, hiring professional home care and more.

The reality is that caring for someone with M.S. is going to be very different than caring for a loved one with any other progressive illness. "Here we take care of people who have both M.S. and other neurological disorders," said Chris Dunbar, a social worker with the Rocky Mountain M.S. Society, who works at the King Adult Day Center in Denver, Col. Mr. Dunbar explained that M.S. lesions affect the brain in different ways -- there might be a person who is barely mobile speaking in whispers who is still very mentally sharp, sitting across from someone who appears physically able but no longer has good judgment or who has other mental and emotional problems. "It can create quite a challenge to the caregiver, and it will change over time," he said.

Doug Hawk is still able to care for his wife in their Denver home, but he knows that his caregiving responsibilities will expand as her M.S. progresses. "The fatigue factor is amazing," he said. "I do a lot of stuff around the house -- I clean the house, I do all the shopping, all the chores."

His wife Jean noticed her first symptoms in 1998 when her arm consistently hurt, and then one day she simply fell down for no reason. She was diagnosed with M.S. in 1999, and after experiencing some vision problems she decided to let her driver's license lapse. At one point, she needed her husband's help injecting her medication daily and nurses trained him how to give his wife injections.

"I think the most important thing is patience," Mr. Hawk said. "You can get overwhelmed. If she needs something, I do it immediately. Just do what you have to do and don't get upset about it. Take it one step at a time."

That same wisdom goes for altering life plans together. "It took us both about a year to come to grips with it after she was diagnosed," he said. "We had thought when we both retired we would take a lot of car trips together. But now we don't do anything. She is exhausted by the time she gets dressed."

Akrista L'Berg of Ohio, blogs with her husband Cir, about his multiple sclerosis and her role as his caregiver at "Life in Spite of M.S." Mr. L'Berg was diagnosed with M.S. almost 20 years ago, but had to quit working 12 years ago when his symptoms interfered with his work as a salesman.

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Leann Reynolds: Multiple Sclerosis and Caregiving

Fiona Phillips: Dementia drugs robbed my father the final weeks of his life

'He was like something out of One Flew Over the Cuckoo's Nest' Fiona's father Neville diagnosed just weeks after her mother succumbed to dementia in 2006 Two sedatives he was given were addictive and could cause cognitive decline, her research revealed

By Vanessa Allen

Last updated at 9:25 AM on 28th February 2012

Television presenter Fiona Phillips has claimed a chemical cosh of dementia drugs robbed her father of the final weeks of his life.

The former GMTV host described how her father Neville was given a vast cocktail of medicines which left him so heavily sedated he was totally out of it.

His medication covered two sides of an A4 sheet of paper, she said.

Heartbroken: Fiona Phillips, pictured with her father Neville in 2009, claimed that dementia drugs robbed him of the final weeks of his life

Alzheimers sufferer Mr Phillips died earlier this month. His rapid deterioration has led his daughter to question whether the drugs cost him years of his life.

She said: I am so angry at the way my lovely, lovely dad was treated at the end. In his final weeks he was so coshed by drugs that his poor body couldnt cope.

They robbed him of his laughter, then his smile, which was all that he had got left, and I am absolutely furious about that. Then they robbed him of his life.

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Fiona Phillips: Dementia drugs robbed my father the final weeks of his life