Super-intelligence and eternal life: transhumanism’s faithful follow it blindly into a future for the elite – The Conversation UK

The rapid development of so-called NBIC technologies nanotechnology, biotechnology, information technology and cognitive science are giving rise to possibilities that have long been the domain of science fiction. Disease, ageing and even death are all human realities that these technologies seek to end.

They may enable us to enjoy greater morphological freedom we could take on new forms through prosthetics or genetic engineering. Or advance our cognitive capacities. We could use brain-computer interfaces to link us to advanced artificial intelligence (AI).

Nanobots could roam our bloodstream to monitor our health and enhance our emotional propensities for joy, love or other emotions. Advances in one area often raise new possibilities in others, and this convergence may bring about radical changes to our world in the near-future.

Transhumanism is the idea that humans should transcend their current natural state and limitations through the use of technology that we should embrace self-directed human evolution. If the history of technological progress can be seen as humankinds attempt to tame nature to better serve its needs, transhumanism is the logical continuation: the revision of humankinds nature to better serve its fantasies.

As David Pearce, a leading proponent of transhumanism and co-founder of Humanity+, says:

If we want to live in paradise, we will have to engineer it ourselves. If we want eternal life, then well need to rewrite our bug-ridden genetic code and become god-like only hi-tech solutions can ever eradicate suffering from the world. Compassion alone is not enough.

But there is a darker side to the naive faith that Pearce and other proponents have in transhumanism one that is decidedly dystopian.

There is unlikely to be a clear moment when we emerge as transhuman. Rather technologies will become more intrusive and integrate seamlessly with the human body. Technology has long been thought of as an extension of the self. Many aspects of our social world, not least our financial systems, are already largely machine-based. There is much to learn from these evolving human/machine hybrid systems.

Yet the often Utopian language and expectations that surround and shape our understanding of these developments have been under-interrogated. The profound changes that lie ahead are often talked about in abstract ways, because evolutionary advancements are deemed so radical that they ignore the reality of current social conditions.

In this way, transhumanism becomes a kind of techno-anthropocentrism, in which transhumanists often underestimate the complexity of our relationship with technology. They see it as a controllable, malleable tool that, with the correct logic and scientific rigour, can be turned to any end. In fact, just as technological developments are dependent on and reflective of the environment in which they arise, they in turn feed back into the culture and create new dynamics often imperceptibly.

Situating transhumanism, then, within the broader social, cultural, political, and economic contexts within which it emerges is vital to understanding how ethical it is.

Max More and Natasha Vita-More, in their edited volume The Transhumanist Reader, claim the need in transhumanism for inclusivity, plurality and continuous questioning of our knowledge.

Yet these three principles are incompatible with developing transformative technologies within the prevailing system from which they are currently emerging: advanced capitalism.

One problem is that a highly competitive social environment doesnt lend itself to diverse ways of being. Instead it demands increasingly efficient behaviour. Take students, for example. If some have access to pills that allow them to achieve better results, can other students afford not to follow? This is already a quandary. Increasing numbers of students reportedly pop performance-enhancing pills. And if pills become more powerful, or if the enhancements involve genetic engineering or intrusive nanotechnology that offer even stronger competitive advantages, what then? Rejecting an advanced technological orthodoxy could potentially render someone socially and economically moribund (perhaps evolutionarily so), while everyone with access is effectively forced to participate to keep up.

Going beyond everyday limits is suggestive of some kind of liberation. However, here it is an imprisoning compulsion to act a certain way. We literally have to transcend in order to conform (and survive). The more extreme the transcendence, the more profound the decision to conform and the imperative to do so.

The systemic forces cajoling the individual into being upgraded to remain competitive also play out on a geo-political level. One area where technology R&D has the greatest transhumanist potential is defence. DARPA (the US defence department responsible for developing military technologies), which is attempting to create metabolically dominant soldiers, is a clear example of how vested interests of a particular social system could determine the development of radically powerful transformative technologies that have destructive rather than Utopian applications.

The rush to develop super-intelligent AI by globally competitive and mutually distrustful nation states could also become an arms race. In Radical Evolution, novelist Verner Vinge describes a scenario in which superhuman intelligence is the ultimate weapon. Ideally, mankind would proceed with the utmost care in developing such a powerful and transformative innovation.

There is quite rightly a huge amount of trepidation around the creation of super-intelligence and the emergence of the singularity the idea that once AI reaches a certain level it will rapidly redesign itself, leading to an explosion of intelligence that will quickly surpass that of humans (something that will happen by 2029 according to futurist Ray Kurzweil). If the world takes the shape of whatever the most powerful AI is programmed (or reprograms itself) to desire, it even opens the possibility of evolution taking a turn for the entirely banal could an AI destroy humankind from a desire to produce the most paperclips for example?

Its also difficult to conceive of any aspect of humanity that could not be improved by being made more efficient at satisfying the demands of a competitive system. It is the system, then, that determines humanitys evolution without taking any view on what humans are or what they should be. One of the ways in which advanced capitalism proves extremely dynamic is in its ideology of moral and metaphysical neutrality. As philosopher Michael Sandel says: markets dont wag fingers. In advanced capitalism, maximising ones spending power maximises ones ability to flourish hence shopping could be said to be a primary moral imperative of the individual.

Philosopher Bob Doede rightly suggests it is this banal logic of the market that will dominate:

If biotech has rendered human nature entirely revisable, then it has no grain to direct or constrain our designs on it. And so whose designs will our successor post-human artefacts likely bear? I have little doubt that in our vastly consumerist, media-saturated capitalist economy, market forces will have their way. So the commercial imperative would be the true architect of the future human.

Whether the evolutionary process is determined by a super-intelligent AI or advanced capitalism, we may be compelled to conform to a perpetual transcendence that only makes us more efficient at activities demanded by the most powerful system. The end point is predictably an entirely nonhuman though very efficient technological entity derived from humanity that doesnt necessarily serve a purpose that a modern-day human would value in any way. The ability to serve the system effectively will be the driving force. This is also true of natural evolution technology is not a simple tool that allows us to engineer ourselves out of this conundrum. But transhumanism could amplify the speed
and least desirable aspects of the process.

For bioethicist Julian Savulescu, the main reason humans must be enhanced is for our species to survive. He says we face a Bermuda Triangle of extinction: radical technological power, liberal democracy and our moral nature. As a transhumanist, Savulescu extols technological progress, also deeming it inevitable and unstoppable. It is liberal democracy and particularly our moral nature that should alter.

The failings of humankind to deal with global problems are increasingly obvious. But Savulescu neglects to situate our moral failings within their wider cultural, political and economic context, instead believing that solutions lie within our biological make up.

Yet how would Savulescus morality-enhancing technologies be disseminated, prescribed and potentially enforced to address the moral failings they seek to cure? This would likely reside in the power structures that may well bear much of the responsibility for these failings in the first place. Hes also quickly drawn into revealing how relative and contestable the concept of morality is:

We will need to relax our commitment to maximum protection of privacy. Were seeing an increase in the surveillance of individuals and that will be necessary if we are to avert the threats that those with antisocial personality disorder, fanaticism, represent through their access to radically enhanced technology.

Such surveillance allows corporations and governments to access and make use of extremely valuable information. In Who Owns the Future, internet pioneer Jaron Lanier explains:

Troves of dossiers on the private lives and inner beings of ordinary people, collected over digital networks, are packaged into a new private form of elite money It is a new kind of security the rich trade in, and the value is naturally driven up. It becomes a giant-scale levee inaccessible to ordinary people.

Crucially, this levee is also invisible to most people. Its impacts extend beyond skewing the economic system towards elites to significantly altering the very conception of liberty, because the authority of power is both radically more effective and dispersed.

Foucaults notion that we live in a panoptic society one in which the sense of being perpetually watched instils discipline is now stretched to the point where todays incessant machinery has been called a superpanopticon. The knowledge and information that transhumanist technologies will tend to create could strengthen existing power structures that cement the inherent logic of the system in which the knowledge arises.

This is in part evident in the tendency of algorithms toward race and gender bias, which reflects our already existing social failings. Information technology tends to interpret the world in defined ways: it privileges information that is easily measurable, such as GDP, at the expense of unquantifiable information such as human happiness or well-being. As invasive technologies provide ever more granular data about us, this data may in a very real sense come to define the world and intangible information may not maintain its rightful place in human affairs.

Existing inequities will surely be magnified with the introduction of highly effective psycho-pharmaceuticals, genetic modification, super intelligence, brain-computer interfaces, nanotechnology, robotic prosthetics, and the possible development of life expansion. They are all fundamentally inegalitarian, based on a notion of limitlessness rather than a standard level of physical and mental well-being weve come to assume in healthcare. Its not easy to conceive of a way in which these potentialities can be enjoyed by all.

Sociologist Saskia Sassen talks of the new logics of expulsion, that capture the pathologies of todays global capitalism. The expelled include the more than 60,000 migrants who have lost their lives on fatal journeys in the past 20 years, and the victims of the racially skewed profile of the increasing prison population.

In Britain, they include the 30,000 people whose deaths in 2015 were linked to health and social care cuts and the many who perished in the Grenfell Tower fire. Their deaths can be said to have resulted from systematic marginalisation.

Unprecedented acute concentration of wealth happens alongside these expulsions. Advanced economic and technical achievements enable this wealth and the expulsion of surplus groups. At the same time, Sassen writes, they create a kind of nebulous centrelessness as the locus of power:

The oppressed have often risen against their masters. But today the oppressed have mostly been expelled and survive a great distance from their oppressors The oppressor is increasingly a complex system that combines persons, networks, and machines with no obvious centre.

Surplus populations removed from the productive aspects of the social world may rapidly increase in the near future as improvements in AI and robotics potentially result in significant automation unemployment. Large swaths of society may become productively and economically redundant. For historian Yuval Noah Harari the most important question in 21st-century economics may well be: what should we do with all the superfluous people?

We would be left with the scenario of a small elite that has an almost total concentration of wealth with access to the most powerfully transformative technologies in world history and a redundant mass of people, no longer suited to the evolutionary environment in which they find themselves and entirely dependent on the benevolence of that elite. The dehumanising treatment of todays expelled groups shows that prevailing liberal values in developed countries dont always extend to those who dont share the same privilege, race, culture or religion.

In an era of radical technological power, the masses may even represent a significant security threat to the elite, which could be used to justify aggressive and authoritarian actions (perhaps enabled further by a culture of surveillance).

In their transhumanist tract, The Proactionary Imperative, Steve Fuller and Veronika Lipinska argue that we are obliged to pursue techno-scientific progress relentlessly, until we achieve our god-like destiny or infinite power effectively to serve God by becoming God. They unabashedly reveal the incipient violence and destruction such Promethean aims would require: replacing the natural with the artificial is so key to proactionary strategy at least as a serious possibility if not a likelihood [it will lead to] the long-term environmental degradation of the Earth.

The extent of suffering they would be willing to gamble in their cosmic casino is only fully evident when analysing what their project would mean for individual human beings:

A proactionary world would not merely tolerate risk-taking but outright encourage it, as people are provided with legal incentives to speculate with their bio-economic assets. Living riskily would amount to an entrepreneurship of the self [proactionaries] seek large long-term benefits for survivors of a revolutionary regime that would permit many harms along the way.

Progress on overdrive will require sacrifices.

The economic fragility that humans may soon be faced with as a result of automation unemployment would likely prove extremely useful to proactionary goals. In a society where vast swaths of people are reliant on handouts for survival, market forces would determine that less social security means people will risk more for a lower reward, so proactionaries would reinvent the welfare state as a vehicle for fostering securitised risk taking while the proactionary state would operate like a venture capitalist writ large.

At the heart of this is the removal of basic rights for Humanity 1.0, Fullers term for modern, non-augmented human beings, replaced with duties towards the future augmented Humanity 2.0. Hence the very code of our being can and perhaps must be monetised: personal autonomy should be seen as a politically licensed franchise whereby indiv
iduals understand their bodies as akin to plots of land in what might be called the genetic commons.

The neoliberal preoccupation with privatisation would so extend to human beings. Indeed, the lifetime of debt that is the reality for most citizens in developed advanced capitalist nations, takes a further step when you are born into debt simply by being alive you are invested with capital on which a return is expected.

Socially moribund masses may thus be forced to serve the technoscientific super-project of Humanity 2.0, which uses the ideology of market fundamentalism in its quest for perpetual progress and maximum productivity. The only significant difference is that the stated aim of godlike capabilities in Humanity 2.0 is overt, as opposed to the undefined end determined by the infinite progress of an ever more efficient market logic that we have now.

Some transhumanists are beginning to understand that the most serious limitations to what humans can achieve are social and cultural not technical. However, all too often their reframing of politics falls into the same trap as their techno-centric worldview. They commonly argue the new political poles are not left-right but techno-conservative or techno-progressive (and even techno-libertarian and techno-sceptic). Meanwhile Fuller and Lipinska argue that the new political poles will be up and down instead of left and right: those who want to dominate the skies and became all powerful, and those who want to preserve the Earth and its species-rich diversity. It is a false dichotomy. Preservation of the latter is likely to be necessary for any hope of achieving the former.

Transhumanism and advanced capitalism are two processes which value progress and efficiency above everything else. The former as a means to power and the latter as a means to profit. Humans become vessels to serve these values. Transhuman possibilities urgently call for a politics with more clearly delineated and explicit humane values to provide a safer environment in which to foster these profound changes. Where we stand on questions of social justice and environmental sustainability has never been more important. Technology doesnt allow us to escape these questions it doesnt permit political neutrality. The contrary is true. It determines that our politics have never been important. Savulescu is right when he says radical technologies are coming. He is wrong in thinking they will fix our morality. They will reflect it.

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Super-intelligence and eternal life: transhumanism's faithful follow it blindly into a future for the elite - The Conversation UK

Links for July 28, 2017: Outlining the GOP tax plan, the ethics of … – American Enterprise Institute

GOP lawmakers, White House outline tax plan WSJ

The final blow [to the Border Adjustment Tax] came Thursday, in a broad statement of principles released by party leaders to build Republican unity on tax policy and create momentum for advancing legislation this fall.

The statement emphasized a common goal of reducing individual and corporate rates and individual tax rates as much as possible. It also called for faster writeoffs for capital expenses, an idea meant to promote investment, though it stopped short of a House Republican proposal for immediate writeoffs.

The shared principles in effect represent a starting point for the approaching debate. Party leaders willingness to release a framework is also a sign of their confidence in getting a bill written and passed.

Still, Thursdays statement left critical questions unanswered, such as how much individual and corporate rates would be cut, and avoided addressing many of the tough trade-offs Republicans would need to make to achieve substantial reductions in tax rates, such as what deductions to eliminate.

Taken together, it included less detail than President Donald Trumps campaign plan, the House GOPs June 2016 blueprint or the one-page White House offering in April.

Shell prepares for lower forever oil prices WSJ

Read more on this, here.

Unions urge slow-down as self-driving car laws pick up speed Bloomberg

A simple way to help low-income students: Make everyone take the SAT NYT

And now the weeks eeriest news, with some reactions:

First human embryos edited in the US Technology Review

Until now, American scientists have watched with a combination of awe, envy, and some alarm as scientists elsewhere were first to explore the controversial practice. To date, three previous reports of editing human embryos were all published by scientists in China.

Now Mitalipov is believed to have broken new ground both in the number of embryos experimented upon and by demonstrating that it is possible to safely and efficiently correct defective genes that cause inherited diseases.

Although none of the embryos were allowed to develop for more than a few daysand there was never any intention of implanting them into a wombthe experiments are a milestone on what may prove to be an inevitable journey toward the birth of the first genetically modified humans.

We need to talk about genetic engineering Commentary

It is incumbent upon Americans of all political stripesnot just conservatives or the faithfulto consider the moral implications of embryonic genetic engineering. In April of 2015, National Institutes of Health Director Dr. Francis Collins issued a statement pledging that NIH will not fund any use of gene-editing technologies in human embryos, but this prohibition does not apply to private endeavors. Public ethos guides private industry, but what is public philosophy regarding the interference with genetic destiny?

Are we obliged to eradicate genetic disorders? Is it unethical not to intervene in the development of an embryo if we have the capacity to alleviate future suffering and hardship? Is it morally questionable to select for various cosmetic traits that prospective parents might find desirable? Do we engage in this process of upending the natural order without knowing the long-term effects of genetic manipulation? Is a modified population a form of eugenics?

If you could design your own child, would you? The Washington Post

We have arrived at a Rubicon. Humans are on the verge of finally being able to modify their own evolution. The question is whether they can use this newfound superpower in a responsible way that will benefit the planet and its people. And a decision so momentous cannot be left to the doctors, the experts or the bureaucrats.

Failing to figure out how to ensure that everyone will benefit from this breakthrough risks the creation of a genetic underclass who must struggle to compete with the genetically modified offspring of the rich. And failing to monitor and contain how we use it may spell global catastrophe. Its up to us collectively to get this right.

Gene editing: new technology, old moral questions The New Atlantis

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Links for July 28, 2017: Outlining the GOP tax plan, the ethics of ... - American Enterprise Institute

UW medical school in Spokane won’t get bigger classes – The Spokesman-Review

University of Washington President Ana Marie Cauce, left, shows off her Gonzaga pen while she and Gonzaga University President Thayne McCulloh, right, sign the formal agreement after the announcement that Gonzaga University would host UW medical students on campus, starting in the fall of 2016. The announcement was Wednesday, Feb. 24, 2016 at Gonzaga University. (Jesse Tinsley / The Spokesman-Review)

For now, at least, the University of Washingtons medical school in Spokane will have classes of just 60 students.

Through a partnership with Gonzaga University, UW welcomed 60 first-year and 40 second-year medical students in Spokane last fall. Earlier this year it asked the Legislature for $9.3 million to add 20 students per graduating class.

But lawmakers were juggling other expensive obligations, including a court order to invest more in K-12 education, so UW received just $5 million for the biennium, enough to support two more classes of 60 medical students.

Our long-term goal is to get to 80 students, said Ian Goodhew, UWs government affairs director. Thats what weve been working on for several years.

Washington State University, which received $10 million for its fledgling medical school in Spokane, also is authorized to serve classes of 60. UWs medical school served significantly fewer students at WSU Spokane before that partnership splintered several years ago.

Goodhew said UW is satisfied with the amount it received. He said lawmakers recognized that the partnership with Gonzaga is off to a pretty great start.

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UW medical school in Spokane won't get bigger classes - The Spokesman-Review

DARK NIGHTS: METAL 101: The Immortal Man & The Four Tribes – Newsarama

Credit: DC Comics

Immortality lies at the center of Dark Nights: Metal. Not only is immortality the driving force behind the investigations being conducted by both Hawkman and Batman, but the event will feature a set of immortal characters in its cast - including one aptly named The Immortal Man.

In Dark Days: The Forge #1, readers discovered that Hawkman has been investigating Nth Metal for years, trying to unlock its abilities. During his studies, he comes to understand that its conducting powerful energy from somewhere beyond his understanding.

That powerful energy is also being investigated by Batman, and the story of its discovery - and the Dark Multiverse it reveals - is at the center of DCs summer event series Dark Nights: Metal, which launches in August and reunites writer Scott Snyder and his Batman co-creator Greg Capullo.

The Forge and its this week's upcoming counterpart Dark Days: The Casting are written by Snyder and James Tynion IV, serving as prequels to Metal and introducing concepts that will form the backbone of the events story.

The Forges Clues

Hawkmans investigation not only leads him to an understanding of energy, but it reveals a link to the Earths past. Hawkman says he got a glimpse of a historic clue - and by glimpse, he was probably referring to one of the visions that he says occur in his reincarnation process, like dreams during his time between lives.

He describes the glimpse as a story that began with the first men to walk the Earth - three tribes. Hes shown to also have some type of artifacts that represent what he discovered about these tribes, as readers are shown what appear to be the sign of a hawk, a bear, and a wolf.

In the same issue, readers were also introduced to the Immortal Man, a modern version of the character from DC Comics history. The character was first introduced in 1965 in Strange Adventures #177, in a story titled I Lived a Hundred Lives.

Immortal Origin

In various stories in Strange Adventures, the character's portrayed ase a modern man who has strange powers he doesnt understand. Raised as an orphan, his only clue to his past lies in an amulet he finds that was left with him when he was a baby. When he looks into the amulet, he remembers that he has lived hundreds of lives, from his time as a caveman until present day, and his body and mind have retained the knowledge they gained during those lives.

There it was before me in the amulet reflection, the character said in his debut. The explanation to all the mystery that plagued my present life! For then and there I realized I had lived not one life, but a multitude of lives.

Originally, the character was only shown to be from a race of powerful cavemen, but in later stories, the Immortal Man was given a more DC-centric origin.

He was Klarn Arg, the caveman leader of the Bear Tribe and archenemy of Vandar Arg of the Wolf Clan (better known as Vandal Savage).

In this origin story, Vandal and the Immortal Mans pre-historic origins were linked - they were battling each other when a meteorite hit the Earth 50,000 years ago.

The meteorite made Vandal immortal, but the Immortal Mans powers lie in an amulet he fashioned from the meteorite. Each time he is resurrected - sometimes as a baby and sometimes as an adult - he is an enemy of Vandal Savage.

Because of this connection between the two characters, and the use of the Bear Tribe and Wolf Clan in their past stories, its likely that the Dark Days: The Forge reference to tribes with the signs of a bear and a wolf refers to these two characters. The hawk that represents the third tribe is probably a sign of Hawkman himself, although its possible it could relate to other DC characters, including the Blackhawks, who are also in The Forge.

Team Player

In post-Crisis continuity, the Immortal Man worked with a team of heroes to stop the evil machinations of Vandal Savage. His team was called the Forgotten Heroes. Although none of those heroes seem to be involved in the current story of The Forge and Metal, a similar idea might be behind the formation of the Immortal Men." This team, also mentioned in The Forge, has been given their own DC title beginning in the fall. Among the team members announced by DC is Immortal Man.

Image from Dark Days: The Forge #1

The description of Immortal Men indicates that five siblings have eternal life, fighting foes in an eternal war. Its not clear whether the Immortal Man is one of these five siblings or not. But in The Forge, as hes discussing the Immortal Men, there are two people talking and four other individuals shown - a total of six. So Immortal Man, whos described in the issue as the great and powerful Immortal Man, may be more of a leader of the five siblings.

In this incarnation, Immortal Man is an older man, with a streak of white in his hair. He works in secret in a lair located a mile beneath Philadelphia. He reveals that he offered Elaine Thomas (mother of Bat-family teen hero Duke Thomas) the opportunity to become immortal somehow. Whether Elaine is one of the Immortal Men, reincarnated without realizing it, or whether the offer was a new one, is not clear.

One of the heroes shown in the Immortal Men scene in The Forge appears to be Native American, and her origin might be tied to the DC hero of the past known as Super Chief. This character, in his original incarnation, was also part of the Wolf Clan and was imbued with powers by a meteorite.

Crisis Tie

Another Bear Tribe member was Anthro, the first boy on Earth who played a key role in Grant Morrisons Final Crisis. Morrison also included the Immortal Man in his Mutiversity mini-series, although the hero was part of a group on Earth-20 and was there revealed to be Anthro, a hero imbued with powers from a meteorite.

Its possible all these meteorites and the energy within them can now be linked to Nth Metal and to the dark energy that will lead Batman to the Dark Multiverse.

Its also obvious, reading through Immortal Mans history, that his powers of reincarnation and flight can be easily connected to Hawkman and Hawkgirl, which seems to be the direction Snyder is heading with Metal.

In the three tribes scene in The Forge, Hawkman adds a fourth tribe - one with the symbol of a bat. This symbol can also be connected to Anthro and Final Crisis, as Batman was tossed back in time by the events in that story and its Morrison-penned follow-up, Batman: The Return of Bruce Wayne.

Struck by the space-bending Omega Beams of Darkseid, Bruce Wayne becomes stranded in time, jumping into different eras - beginning with the paleolithic era. During his time as a caveman, he fights against the tribe led by Vandal Savage.

The word Crisis is also used by Immortal Man himself in the issue, although it refers to future possibilities. He says the "world of public heroes is careening toward a crisis unlike anything they've seen before."

Looking at Immortal Mans history and the Metal possibilities for his Immortal Men and Hawkmans tribes, its pretty clear that Snyder is connecting many different dots in the history of the DCU. And although the entire picture wont become clear until readers get their hands on Augusts first issue of Metal, there are definitely some obvious lines being drawn related to immortality in the DCU.

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DARK NIGHTS: METAL 101: The Immortal Man & The Four Tribes - Newsarama

Maradona, the mafia and immortality: three decades on from Napoli’s Holy Grail – The42

Image: Peter Robinson

THERES A NEAPOLITAN phrase A carta vicino o fuoco sappiccia which literally means that paper close to a fire will inevitably go up in flames.

Of course, Diego Maradonas seven-year stint with Napoli did end tumultuously butamidst the cocaine and the mafia and the bastard son, there was a multitude of success too.

The city of Naples gritty, tough, uncompromising was and very much remains his spiritual home. He fled, in disgrace, 26 years ago but earlier this week, at a glitzy ceremony where he was granted honorary citizenship of the city, it was like he had never left.

Its understandable.

Maradona, after all, gave Napoli immortality.

He arrived in 1984 having tired of the endless kickings he received on the pitches around Spain. Memorably, his last appearance for Barcelona came in the Copa del Rey final against Athletic Club the league champions which culminated in a post-game free-for-all at the Santiago Bernabeu after Maradona retaliated to some verbal abuse with physical retribution.

With relations already strained between him and the club on account of his injury problems and the teams on-field struggles, there was certainly no going back after such a high-profile humiliation for Barcelona footballs most expensive signing and marquee name instigating a mass brawl in front of the King of Spain and millions of TV viewers.

When Maradona touched down in Naples for another world record amount (5m is the oft-quoted figure but in his superb biography of Maradona, Hand of God, author Jimmy Burns says it was, in fact, double that amount), it was treated like the Second Coming of Christ.

But Maradona would not just resurrect himself but, instead, an entire community. His signing became a symbol. Treated with disrespect and contempt by those in the north of the country, Naples was seen as the runt of the litter. To many in Italy it was a seedy, grim, unforgiving place. While it was left in the shadows in terms of politics and economics, it had struggled to compete on the football pitch also. Prior to Maradonas arrival in 1984, nine of the previous 10 championships had been won by teams based in just two cities Milan and Turin.

So, even when there were whispers about a possible deal for Maradona, supporters couldnt contain their level of excitement and anticipation. It would send a message to the rest of Italy.

When Barcelona demanded an extra couple of hundred grand during negotiations, thousands of local fans turned up a Naples building city to hand over their contribution to the pot. Within a day, the money was raised and not long after Maradona was unveiled.

Still, his time with Napoli is largely associated with the Camorra the citys mafia organisation. They were intrigued by what Maradonas signing could do for them: an increase in ticket sales (60,000 season tickets were sold for Maradonas debut campaign) would see exponential growth in touting a staple of the Camorra diet while there was also the economic value of Maradona coming to Naples and how it affected the Camorras other interests. Finally, they also took control of Maradona-related merchandise in the city. According to Burns, they made Maradonas agent, Jorge Cyterszpiler an offer he couldnt refuse.

Source: Peter Robinson

In many ways, it was an atmosphere that Maradona revelled in. In many ways, he saw the local gangsters as mirror images of himself. They had come from humble beginnings and graduated to positions of influence and power. They were rich and enjoyed nice things. Maradona slotted in quite effortlessly.

And, relatively quickly, he found his feet on the pitch too. There was an eighth-place finish in 1985 but Maradona still managed 14 goals and Napoli were only 10 points fromunfashionable champions Hellas Verona.The following season they were better and finished third. Maradona hit double-figures again before heading to Mexico and captaining Argentina to World Cup success.

This was him in his pomp.

There is a neat geographical metaphor regarding Naples vicinity to Mount Vesuvius. Locals get a daily reminder of the threat however inexplicable of eruption and the possibility of destruction. Maradona is the personification of that. But, like the Camorra example, he seemed to take great comfort from the chaos, like it was reassuring. If things were quiet for too long, Maradona would get suspicious. The cyclical explosions became normal.

So, as he excelled with Napoli, his private life was in disarray. His marriage to childhood sweetheart Claudia was falling apart and for a four-month period between December 1985 and March 1986, hed had a fling with a 20-year-old local woman named Cristiana Sinagra.

Source: SVEN SIMON

But when she became pregnant with his child, everything changed. The relationship ended, Maradona ignored his responsibilities, concentrated on the World Cup preparations and gleefully repaired things with Claudia.

The child a son- was born in September 1986 and Cristiana called him Diego Armando after his father. Quickly, the media latched onto the story and Cristiana was open with the press. She had nothing to hide and had been shunned by Maradona. Publicly, he lied, believing ignorance would be bliss.

About this I know nothing absolutely nothing, he said.

It would take five long years and a legal case for Maradona to change his tune.

By that stage, he had been forced into exile and his time with Napoli had come to an end owing to a 14-month suspended sentence for cocaine possession. Simultaneously, he had been banned from football for 15 months and both his professional and personal lives were in free-fall.

Still, if the paper ultimately went up in flames, Maradona had exceeded expectations in Naples.

1987 was the beginning of an unprecedented period of dominance for the club. Maradona scored 10 times as Napoli lost just two games in the entire league season to be crowned Italian champions for the very first time. They had already claimed a Coppa Italia and the celebrations were like nothing the city had ever seen.

Source: Peter Robinson

Everything stopped for a week as people partied in the streets. Sleep was negotiable. Perhaps no one really wanted to wake up from the dream.

Least of all Maradona himself.

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Maradona, the mafia and immortality: three decades on from Napoli's Holy Grail - The42

‘Fusion genes’ drive formation and growth of colorectal cancer – Medical Xpress

July 12, 2017 by George Lowery Mouse intestinal organoids that scientists genetically engineered to study colon cancer. Using gene editing technology, the investigators fused together the genes Ptprk and Rspo3 to determine their effect on cancer development. Credit: Cornell University

Genetic mutations caused by rearranged chromosomes drive the development and growth of certain colorectal cancers, according to new research conducted by Weill Cornell Medicine investigators.

Many of the genetic mutations present in colorectal cancer have been known for decades. But their exact role in cancer's development and progression has not been clear. "We knew that these mutations existed, but not whether they contribute to the disease," said Lukas Dow, an assistant professor of biochemistry in medicine and a member of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine. "So we are interested in whether they are actually driving cancer and whether they can potentially be targets for drugs that treat it."

In a paper published July 11 in Nature Communications, Dow and his colleagues describe how large pieces of chromosomes are deleted or inverted, resulting in new, mutated so-called fusion genes created from parts of two other genes that are responsible for the formation of some colon cancers.

The researchers used the gene editing technology CRISPR, which allows scientists to easily alter any piece of DNA in an organism, to cut the DNA in normal human intestinal cells and create fusion genes. In this way, they engineered the genetic mutations in two genes Rspo2 and Rspo3 known to be associated with colorectal cancer. They then created mice containing these genes to study the genes' effect on colon cancer development.

Though CRISPR has received a lot of attention in the last several years, this is the first time the tool has been used this way. "We created the first CRISPR-based transgenic animal model for inducing large-scale chromosomal rearrangements," Dow said.

These chromosomal rearrangements in the Rspo genes did in fact initiate growth of colon cancer in the mice. The mice containing the engineered genes developed multiple precancerous tumors that are the precursors to colorectal cancer. "This is the first evidence that these specific fusions can drive tumor development," Dow said.

Dow's team went on to treat the mice that developed cancer with an experimental drug, LGK974, which blocks a protein necessary for Rspo fusion genes to cause disease. "The tumors shrank and the mice were fine as long as they continued to take LGK974," Dow said. In addition, the drug only suppressed growth of the cancer cells; it had no obvious negative effect on healthy cells in the mouse intestine.

The study's results hold particular promise for the treatment of colorectal cancer in humans, Dow said. This form of cancer has historically been a difficult disease to treat. Chemotherapy drugs have limited impact against colorectal cancer and developing targeted therapies drugs that target aspects of cancer cells that make them different from healthy cells has proven difficult. "Our results give us confidence that if we can deliver LGK974 effectively to patients with these fusion genes," Dow said, "then we should be able to see some tumor response with these targeted agents."

Explore further: Novel gene editing approach to cancer treatment shows promise in mice

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FDA advisers review data on potential 1st US gene therapy – Lexington Herald Leader


Santa Fe New Mexican
FDA advisers review data on potential 1st US gene therapy
Lexington Herald Leader
The Food and Drug Administration panel is holding a hearing Wednesday to discuss the treatment developed by the University of Pennsylvania and Novartis Corp. The drugmaker is seeking approval to use the one-time treatment for children and young ...
First gene therapy on the cusp of FDA approvalSanta Fe New Mexican

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FDA advisers review data on potential 1st US gene therapy - Lexington Herald Leader

Don’t let the US lose its biotechnology edge – Baltimore Sun

The second annual Biodesign Challenge Summit just wrapped up at the Museum of Modern Art in New York City. In all, 22 teams from universities in seven countries presented creative ideas for a biology-infused future, envisioning such things as:

The winning project came from Central St. Martins in the U.K., for their concept of using earthworms in abandoned coal mines to harvest commercially important metals; this would give economically depressed communities a new source of revenue and jobs and would also clean the environment.

For these students, the increasing powers of biotechnology raise important ethical and societal questions, but they see biotechnology largely as a source for hope for our planet. If used properly, biotechnology could rescue species in trouble, such as purple martins, bees and coral. It could also to make it easier for people to discard less, and reuse more. As a judge in this competition, the students hopefulness, inventiveness and concern for our planet and all its inhabitants was clearly inspiring: We should all hope they are able to shape a positive future for biotechnology.

But a technologys development rests upon its developers, and the benefits, including jobs, will go to the market they cater to and it is no longer clear that the U.S. will be that market. This is concerning, not only because those benefits could accrue here in the U.S., but because the governance and safety of new biotechnologies will be in the hands of those who are the scientific leaders in the technology.

For now, the U.S. is a biotechnology world-leader and has the potential to benefit the most in jobs and in products. Synthetic biology, a relatively new field that aims to make biology easier to engineer, was born in the U.S., and the US is still in the lead; Fidelity Investments describe synthetic biology as the defining technology of this century and the World Economic Forum ranks it within the top 10 emerging technologies. But other nations are investing heavily and supporting their scientists, and there is mounting concern that the U.S. is not just losing its competitive advantage, but actually falling behind. Most of the competition is coming from China. More than a quarter of the worlds DNA sequencing capacity is contained within one Chinese company, and China already produces more life science and engineering PhDs. Chinese scientists used CRISPR a gene editing technique that is similar to the find and replace function in Word to treat a patient with metastatic lung cancer, and they were the first to proceed using CRISPR in a biomedical trial.

Whether or not the U.S. falls behind in synthetic biology and other biotechnologies is a choice our political leaders will make by neglect. Failing to fund synthetic biology would be damaging to the U.S. economy, as well as national security, both because a strong economy underwrites our military strength and diplomatic influence, and because these technologies can boost our defenses against natural and man-made biological threats. The way to counteract this is to not make cuts to biomedical and synthetic biology research funded by the U.S. government, but to redouble efforts, so that future jobs and opportunities dont leave Americans out of a bio future.

The theme of the students biodesign exhibition was the future will be grown. But there are important questions that face us as we fund our government research agencies in the years ahead: Who, specifically, will grow that future? What will be grown? And to what end? These next several years will be formative in setting the rules of the road for synthetic biology and other biotechnologies. The U.S. must remain in a prime technological position and provide global leadership to ensure that synthetic biology is used for the benefit of the American public, for the benefit of U.S. national and economic security, and indeed, for the benefit of humankind.

Gigi Kwik Gronvall (ggronvall@jhu.edu) is a senior associate at the Johns Hopkins Center for Health Security and visiting faculty at the Johns Hopkins Bloomberg School of Public Health. She is the author of Synthetic Biology: Safety, Security, and Promise (2016).

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Don't let the US lose its biotechnology edge - Baltimore Sun

Biocartis and A*STAR ink breast cancer R&D contract – European Biotechnology

Belgian diagnostics company Biocartis Group NV and Singpores A*STAR ETPL have kicked off development of a multimodal breast cancer assay designed to guide therapy selection in personalised medicine.

Both parties did not disclose any information about the worth of their five-year strategic partnership aimed at the development of a PCR assay for breast cancer detection running on Biocartis' diagnostic Idylla(TM) platform. This first assay selected for development under the partnership is a solid multimodal FFPE biopsy assay, aimed at supporting optimal therapy selection decisions for Her-2-positive, hormone receptor-positive, and undisclosed breast cancer target-positive breast cancer patients, the companies said.

Under the terms of the agreement, ETPL and Biocartis will co-invest in the development of several jointly selected tests. Biocartis will commercialise the tests under its own label, while ETPL will act as a development partner through Singapore's Diagnostics Development (DxD) Hub.

Breast cancer is the the largest segment of the cancer diagnostics market, with expected sales of US$13.1bn by 2020. According to Biocartis, an increasing number of targeted and hormone therapies for breast cancer drives the demand for assays that guide therapy selection. While Her2 may occur in up to 20% of breast cancers, according to optimistic estimates, hormone receptor expression is estimated to occur in poentially two-thirds of women with breast cancer.

While most health systems have not yet switched to reimbursement of genome sequencing-led cancer profiling, multimodal biomarker testing is currently diagnostic state of the art. Some diagnostic companies, however, are already preparing to launch sequencing based biomarker detection to improve patient stratification.

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Biocartis and A*STAR ink breast cancer R&D contract - European Biotechnology

Controversial Studies Suggest Coffee Drinkers Live Longer – Gizmodo

Coffee drinkers, rejoice. Two new studies are linking our favorite hot beverage to a decreased chance of being killed by heart disease, cancer, a stroke, and more. So, does this mean we can start drinking coffee with reckless abandon? We spoke to the experts to find out, and not surprisingly, the answer is complicated.

People who drink coffee appear to live longer, according to a pair of studies published today in the Annals of Internal Medicine. The studieswhich involved hundreds of thousands of participants across a diverse set of ethnic groupsshowed that folks who drink at least one cup of coffee a day were 12 percent less likely to die of diseases such as heart disease and cancer. This effect jumped to 18 percent among people who consumed two to three cups per day. Importantly, these associations held true for participants who drank either caffeinated or decaffeinated coffee, which would seem to imply that caffeine has nothing to do with it.

But to say that these studies close the case on coffee, so to speak, would be taking it too far. The researchers werent able to identify a causal relationship, nor were they able to explain why coffee appears to confer these health benefits. And importantly, some experts are challenging the conclusions reached in these two studies, saying the results were misleading, and that blanket statements about coffee consumption ignore the fact that, for some, caffeine is dangerous.

Regardless, the new studies offer substantial findings given the stigma associated with coffee consumption, and the fact that an estimated 2.25 billion cups of this delicious beverage are consumed each day around the world. Coffee has previously been linked to bladder cancer, increases in the risk of heart disease, stomach ulcers, and heartburnyet little evidence exists to support these largely debunked claims.

And in fact, quite the opposite appears to be the case. One recent meta-study linked coffee consumption to a reduced risk of liver and uterine cancer. Evidence is also mounting that coffee may protect against heart disease, type 2 diabetes, and Parkinsons. These findings sure seem promising, but skeptics have argued the jurys still out on coffee, pointing to deficiencies in the research methods, such as a focus on specific ethnicities, or failing to follow-up with study participants. The two new analyses provide some of the most compelling evidence yet in support of coffees purported health aspects.

In the first study, a research team from the University of Southern California found that higher coffee consumption was linked to lower risk for death in both white and non-white populationsan important finding given that different ethnicities have different lifestyles and disease risks. Coffee consumption amounting to two to three cups a day, for example, was associated with a reduced risk of death due to heart disease (21 percent decrease), cancer (8 percent decrease), stroke (27 percent decrease), diabetes (23 percent), and respiratory (10 percent) and kidney disease (41 percent).

Crucially, these findings were generalizable across cultures, including African-Americans, Japanese-Americans, Native Hawaiians, Latinos, and whites. Health effects were observed in all of ethnicities studied.

Data came from the Multiethnic Cohort Study, a collaborative effort between the University of Hawaii Cancer Center and the Keck School of Medicine that involves more than 215,000 participants. Every five years, participants fill out questionnaires about their diet and lifestyle, along with family and personal medical history information. The average follow-up period is 16 years. When analyzing the data, the USC researchers adjusted for age, sex, ethnicity, smoking habits, education, pre-existing disease, physical exercise, and alcohol consumption.

This study is the largest of its kind and includes minorities who have very different lifestyles, said Veronica Setiawan, lead author of the study, in a statement. Seeing a similar pattern across different populations gives stronger biological backing to the argument that coffee is good for you whether you are white, African-American, Latino or Asian.

Among coffee drinkers, reduced mortality rates were present regardless of whether participants drank caffeinated or decaffeinated coffee. So, whatever is causing the added longevity appears to have nothing to do with caffeine.

Crucially, the USC researchers arent saying that coffee prolongs life, just that an association has been found between coffee consumption and longevity. Correlation does not necessarily imply causation, and the study didnt point to any chemicals or compounds in coffee that explain these health effects. Still, according to Setiawan, it is clear that coffee can be incorporated into a healthy diet and lifestyle.

In the second study, researchers from the Imperial College London and International Agency for Research on Cancer (IARC) came to similar conclusions, though using a different subset of participants. In the largest study of its kind, the scientists analyzed survey data from more than half a million people across ten European countries, and found that people who drink around three cups a day tend to live longer than non-coffee drinkers. They found coffee drinkers to have a reduced risk of death from all causes of mortality, including circulatory diseases and diseases related to the digestive tract. And like the other study, decaf drinkers saw these reduced mortality rates just as much as folks drinking regular coffee.

For the study, the ICL and IARC researchers looked at data from the EPIC study (European Prospective Investigation into Cancer and Nutrition), which included 521,330 people over the age of 35. Diets were assessed with questionnaires and interviews, and again, the researchers controlled for factors such as diet and smoking (interestingly, people who drank more coffee were more likely to be younger, smokers, and regular alcohol drinkers). After 16 years of follow-up, nearly 42,000 people who had enrolled in the study had passed away, dying from a range of conditions, including cancer, circulatory diseases, heart failure and stroke.

We found that drinking more coffee was associated with a more favourable liver function profile and immune response, explained lead author Marc Gunter. He added: Due to the limitations of observational research, we are not at the stage of recommending people to drink more or less coffee. That said, our results suggest that moderate coffee drinkingup to around three cups per dayis not detrimental to your health, and that incorporating coffee into your diet could have health benefits.

Miriam Nelson, Director of the Sustainability Institute at the University of New Hampshire, is excited by these findings, and says these two studies are bigger and more diverse than previous investigations. Nelson, who wasnt involved in either study, was impressed by the length of the follow-ups, the size of the cohorts, and the cross-cultural examination. Yet she emphasized that there are still many things these studies dont tell us.

We still dont understand how high coffee consumption affects pregnancy, and we dont know what high coffee consumption does to children, Nelson told Gizmodo. She says its still inappropriate to give coffee to children, adding that theres very little doubt that coffee affects our sleep, at least for some individuals. People who drink tons of coffee, and who have serious sleep issues, may want to take the new findings with a grain of salt.

Then, of course, theres all that crap we put into our coffee.

If you enjoy coffee, then feel free to drink it, perhaps even three to five cups a day, said Nelson. Coffee has health benefits, but we need to be wary of adding extra calories with sugar and cream. We need to be smart.

But Paolo Palatini, Head Vascular Medicine at Italys University of Padova, was profoundly unimpressed with the new research. After reading the papers I was horrified about how these articles...are cursory and biased, he told Gizmodo. As soon as they are published I will write a letter to the editor [of The Annals of Internal Medicine] to express my criticisms. In a word, he thinks the studies are misleading.

In the papers the authors did not discuss the issue of the different types of coffee that may have different impact on outcomes, he said. In the European study they evaluated coffee in milliliters which is absurd because in Italy cups contain 30-40 ml of concentrated coffee whereas in most European countries cups are much larger. This minimized the effect of Espresso coffee which may be deleterious compared to others.

He says the groups of coffee drinkers surveyed in both studies were unbalanced, the most significant imbalance being the large percentage of smokers among the heavy coffee drinkers. Results for coffee subgroups differ in the two studies, and adjustment for smoking can hardly be applied, he said. At any rate, the two studies demonstrate that coffee drinkers also are smokers which is very deleterious for health, and this aspect is completely neglected by the authors.

Palatini also doesnt buy the idea that caffeine has no effect on health outcomes, pointing to his own research showing the importance of caffeine metabolism on cardiovascular disease, and how genetics plays a critical role. Hes also shocked that none of the researchers referenced an Italian study showing the negative effects of coffee on cardiovascular outcomesan omission Palatini says was done on purpose and is unacceptable.

Ultimately, Palatini says we need to be wary of coffee (and caffeine in particular) because it increases a persons sympathetic activity, changes to the nervous system that can lead to an accelerated heart rate and raising of blood pressure,which is especially dangerous among coronary patients. He says its not good for slow caffeine metabolizers (folks who take longer to break down caffeine), causing caffeine to accumulate in their blood where it can lead to negative effects. Concluding that coffee is safe without distinguishing between different clinical conditions is misleading and may encourage patients to drink as much coffee as they wish, Palatini said.

Rob M. van Dam, an associate professor of epidemiology at the Saw Swee Hock School of Public Health at the National University of Singapore, was a little less harsh toward the new findings. These studies on coffee and mortality are based on large well-conducted cohort studies, van Dam, who wasnt involved in either study, told Gizmodo. The results that coffee consumption is associated with a moderately lower risk of mortality during follow-up is not surprising as this has been reported for several previous studies. The new studies add to the available evidence as they show consistent results in various ethnic groups in the U.S. and different countries in Europe.

These generous words aside, van Dam said the only way to truly determine the truth is to conduct randomized trials of coffee and health outcomes. In other words, to run actual experiments.

Coffee is a plant food that is rich in chlorogenic acid and related phenolic compounds, carbon-based molecules with ring-like structures, that reduced blood glucose levels in animal studies, he said. It also contains trigonelline, a precursor of vitamin B3, several minerals such as magnesium, and vitamins such as vitamin B3. He says phenols in coffee confer various health effects, such as reducing the ability of intestines to absorb glucose, preventing the liver from expressing too much glucose, and regulating healthy insulin responses.

But van Dam was also quick to point out that excessive caffeine consumption can lead to unpleasant symptoms, such as nervousness, the jitters, and disrupted sleep. If youre experiencing any of these [symptoms] it is appropriate to cut down on [coffee] consumption. He added that caffeine consumption during pregnancies might reduce fetal growth and increase a womans chance of having a miscarriage. Limiting caffeine consumption in pregnancy to one regular size (~8 fl oz) cup of coffee or less seems thus appropriate.

So where does all this leave us? Clearly, coffee has a lot going for it, and as these new studies attest, it might confer some tremendous health benefits in certain individuals. But a one-size-fits-all approach to coffee drinking is not appropriate. If youre a coffee drinker, be mindful of how coffee affects your health and mental well-being, and adjust accordingly. If you think coffee may exacerbate a pre-existing health condition (such as sleep disorders or cardiovascular health), talk to your doctor. And if youre pregnant, cut back to a cup a day at most.

Otherwise, enjoy that tasty brew.

[Annals of Internal Medicine I & II]

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The art of construction: Chemistry lab takes center stage in an artist’s exhibition – MIT News

From many perspectives, a construction site represents a headache an area in flux, hovering between functional and unusable, a source of financial and emotional stress. When will the work be completed? When can the area return to its finished state? And will it be done by the estimated, yet counted upon deadline, for the estimated, yet counted upon budget? To perceive a space mid-renovation in any other way to take it even further and actually be inspired, as opposed to daunted requires a truly unique vision. Angel Chen MS '17, a recent masters degree recipient from MITs Program in Art, Culture, and Technology (ACT), not only possesses that vision, but defines it.

Chen, who received her bachelors degree in philosophy and computer science from McGill University in 2009, came to MIT in 2015, and made quite an impact over the course of her time in ACT. The 2017 second-place recipient of MITs Harold and Arlene Schnitzer Prize in the Visual Arts, Chens art practice at MIT has revolved around understanding complex and technical systems. [ACT] supports my background and interest very well because it encourages experiments in new modes of relating a critical art practice to culture and to technology, she explains.

When it came time to execute her thesis work, Chen set off in search of a construction site on campus to stage an art installation. She pitched her idea to create an artwork that would explore the connection between building construction and nanoscale fabrication to Dick Amster, MITs director of campus construction. Amster then put her in touch with Janis Burke, manager of the Institutes Committee for Renovation and Space Planning, who introduced Chen to four project managers and their respective renovation projects on campus.

One of the projects in contention was the renovation of Department of Chemistry laboratory spaces on the fourth and and fifth floors of Building 18, overseen by campus construction project manager Meredith Fydenkevez. Fydenkevez was assisted by project coordinators Julie Azzinaro and Mike Morizio. Members of the project team also included Department of Chemistrys administrative officer Richard Wilk and facilities administrator Brian Pretti. Columbia Construction Company was represented by project manager Mike Ausevich, assistant project manager Sarah Neff and field superintendent Erik Julio.

Chen presented her idea to the project team, and they determined the project could accommodate her request to utilize the space during construction. Department of Chemistrys senior administrative assistant Emrick Elias assisted by providing Chen daily access to the space, with construction beginning in May. The spaces will soon belong to Professor Laura L. Kiessling, and in order to accommodate her research group, they had to undergo a few changes. When Chen first viewed the fourth floor space in April, prior to the start of any construction, she was immediately drawn to it. I was initially attracted to quality of the natural light I experience walking down the hallway. It makes you want to believe in something, or at least be hopeful for something, she said.

Chen also discovered a meaningful connection to the building as a whole: My ACT studio is in an I.M. Pei building from 1985, and Building 18 is also designed by I.M. Pei, but in 1967. 1967 is also the year my program's predecessor, Center for Advanced Visual Studies (CAVS), was created. Going in between these spaces inspired me to reflect on how artists and scientists came together to collaborate at different times in the history of the Institute. Having landed on the perfect location, Chen began production on the art installation, entitled Looking for Space: Arriving at a Laboratory Under Construction.

From April 18 through May 23, Chen was a daily fixture in the fourth floor construction site, arriving at various times of day, staying for intermittent amounts of time, and absorbing the environment as a whole as well as the minutiae that made up the space. Every little interaction was very meaningful to me, she says. All the interactions together make up one very memorable and impactful moment. I did really enjoy being surprised by what would happen at any given day running into people at the elevator, Brian and Meredith bringing me a MIT hardhat with my name on it, and the quiet but continuous alarm sound the cold room made when it was put to rest.

Ultimately, Chens project evolved into more than what she had originally intended; it became not only a place for an art installation, a site in transition/in flux/in limbo to be witnessed and photographed, but also a nest of sorts. Chen described the spaces evolution from her expectation to the ultimate result in the description of her installation as a place to spend time in, to reflect on my position as an art student. By forming this nest, through every day interacting, observing, and learning, I encountered specific people, procedures, processes, traces, gossip and memories that together make up this place.

On May 22, Chen opened the installation for her fellow ACT classmates, as well as professors both from MIT and beyond, as a public display of her thesis work. Groups donned hard hats and walked through the renovation that had become Chens nest, observing the items she had carefully arranged amidst the chaos, dust, and debris of an ongoing construction zone. Chens goal for the scene was to instigate a different way of thinking. My intention was to create a space that really urges people to look at a lab space differently, regardless of where they are coming from, through paying attention to different materials, to placements of objects, through trying to discern which things have been brought in by me from my studio, and through noticing traces of time as demonstrated by marks left by many different people, machines, and processes. That the lab is under renovation means that certain aspects electrical outlets, walls are quite literally open, adding to the mix of materials.

The exhibit was a multifaceted success, for Chen, for the Department of Chemistry, and for all who had the privilege of experiencing it firsthand. This project, Chen muses, experimental in nature, has given me an incredible opportunity to develop artistic research and exhibition-making methods that I will take with me and continue to refine for years to come. Chens work has inspired a thoughtfulness among those who work in Building 18. It has promoted the notion that the space that is experienced on a daily basis can be easily taken for granted. Moments are finite, and the lab renovation on the fourth floor of Building 18 will soon be complete, but Chens artistic vision helped to instigate an appreciation for the fleeting passage of time, and all of the tiny elements that make up an average day.

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The art of construction: Chemistry lab takes center stage in an artist's exhibition - MIT News

The perpetual journey of innovation – Enterprise Innovation

Four years ago, mega technology trends revolved around big data, the cloud, mobility, and the start of the Internet of Things (IoT). Fast forward to 2017, technology have been built on the foundation of these mega trends, and has seen a massive breakthrough with innovations that have and will continue to disrupt businesses, modernize economies and accelerate growth across industries.

As we journey through this year, we will see technology and our everyday lives be intertwined more than ever before, with organizations undergoing digital transformations at different scales across the world. The technology framework for the future is taking shape to revolutionize how we conduct businesses and take on new challenges in an increasing digitalized economy.

The question is, what is the endpoint to which we see technology being part of our lives? Lets take a simple example of fitness tracker devices embedded with IoT sensors. It can track your steps and exercise routines, sync it with your smartphone and translate all that data into insights on your progress. Pretty amazing, when it became mainstream in the late 2000s at least. But like many other technologies, we are starting to get used to moving on quite rapidly, wanting something better, more powerful, more useful. We crave for innovative technology simply because we can. Because of such rapid changes and our hunger for more, companies have been forced to accelerate innovation and pay more attention to preparing ourselves for the future. Which is why technology today has become increasingly scalable and easily adaptable to future environments. With software primarily at its core, its become nimble. So, to the earlier question, the simple answer is that there is no endpoint to what technology can offer in this day and age, and we must prepare ourselves for the perpetual journey of innovation.

With todays youths being the driving force for tomorrows economy, it is more pertinent now than ever before for youths to embrace new technology innovations, to be able to leverage technology effectively in the future. In fact, we recently conducted a survey of 1,400 youth across Asia Pacific to understand how they view their digital future, and what they found as the three most exciting technologies are Artificial Intelligence, Mixed Reality and Internet of Things.

The study also found that the top benefits they wanted out of these technologies were to help them increase their productivity, facilitate the way they connect with people and improve their physical and mental health. This indicates an understanding on the deeper impact they will have on our lives.

Let us take a closer look at these technologies that will continue to evolve and why they stand out as some of the most important in our future.

Artificial Intelligence

Artificial intelligence (AI) may still seem like stuff of science fiction for some of us, but it is already present in our everyday lives and work. And we are not talking about robots with limbs, but rather technology that can already understand what humans can do, like language, facial recognition, virtual personal assistants or predictive services like identifying what we like to read and making appropriate recommendations.

That said, AI is indeed evolving quickly and is now being used in much more advanced ways, and is being developed and run with even more precision to address deeper issues like healthcare, poverty, terrorism and autonomous vehicles. Today, self-driving cars are already being tested on roads in some cities, smart homes are being marketed, capabilities in biology and genetic engineering are starting to change not only human health and the healthcare industry, but also the way we think about and manage livestock.

Industries will need to continue to leverage machine learning as an ally rather than a threat (to potential job losses, for example). With AI capabilities driving their digital transformation initiatives in an expanding digital economy, AI will to gain more prominence, giving new meaning to automation and breaking grounds for real time solutions and powered by cloud technology.

Mixed Reality

For as long as one could remember, interactions with PCs, tablets and phones have always been a simple point and click, or touch and flick. The introduction of Mixed Reality devices has transformed the way we live, engage and connect. As physical and virtual worlds intersect in new ways, mixed reality allows for a more immersive experience for working remotely or supporting future workplaces to improve collaboration, and tackle organizational challenges anytime, from anywhere.

Beyond the immersive experience however, mixed reality has gone much further in redefining how we can break down geographical barriers. Think about NASAs Mars exploration project and how they have virtually brought Mars to Earth through mixed reality, for an entirely new way of exploration and learning experience.

Internet of Things

Internet of Things (IoT) continues to solicit indelible support from industries worldwide as businesses undergo digital transformation. The global IoT market is expected to reach USD724.2 billion by 2023, according to a report by Research Nester. With the proliferation of technology and rapid growth of urbanization, organizations will continue to adopt and adapt to new technological solutions that will drive business to new frontiers.

New IoT solutions will leverage AI and machine learning to interact with humans and the surroundings, such as drones, self-driving cars, smart kitchens/homes which will be increasingly integrated into daily living.

IoT will also push businesses a step further by offering them immeasurable insights into customers minds, and organizations will be able to create, change and ensure customers value from these insights.

Looking Ahead

We can only look forward to an exciting and smarter future, with many technologies inevitably shaping our global economies and our future. The notion that change is the only constant holds true especially in the wake of our fast paced, innovative and increasingly digitalized economy.

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The perpetual journey of innovation - Enterprise Innovation

Genetically modified food is too advanced for its out-of-date regulations – The Hill (blog)

Last week, the USDA published a series ofquestionsseeking input to establish a National Bioengineered Food Disclosure Standard, as mandated by amendments to the Agricultural Marketing Act of 1946 that went into effect in July 2016.

TheNational Bioengineered Food Disclosure Standard Actrequires the Secretary of the Department of Agriculture to establish disclosure standards for bioengineered food. The Act preempts state-based labeling laws for genetically modified organisms (GMOs), such as those adopted inVermontlast year.

The USDA is considering public input on the disclosure standards untilJuly 17, 2017. Two key issues are under consideration. The first is whether certain genetic modifications should be treated as though they are found in nature for example, a mutation that naturally confers disease resistance in a crop. The second concerns what types of breeding techniques should be classified as conventional breeding among "conventional breeding" techniques are hybridization and the use of chemicals or radiation to introduce random genetic mutations.

These seemingly mundane questions strike at the heart of GMO controversies and implicate the use of breakthrough CRISPR gene editing technologies. Gene editing allows novel and precise genetic modifications to be introduced into crops and animals intended for human consumption. The answers to the USDA's questions are significant because the Disclosure Standard Act exempts from mandatory disclosure genetic modifications obtained without recombinant DNA (rDNA) techniques that can otherwise be found in nature.

However, CRISPR gene editing need not rely on using any foreign DNA and can introduce genetic modifications that mirror those already found in nature. Unlike rDNA and conventional breeding methods, CRISPR technologies introduce genetic changes with far greater accuracy and precision.

In 2016, the USDAdeclined to regulatetwo CRISPR crops a mushroom and a waxy corn under regulations governing traditionalGMOs. But other regulatory agencies, including the FDA and EPA, have not yet made determinations on crops or animals modified with CRISPR technology, and uncertainty looms concerning the regulatory status of this new breed ofGMOs.

Opponents ofGMOs, who commonly argue thatGMOsare harmful to human health, decried the USDA's decision not to regulate CRISPR crops and argued thatpowerful corporations had found ways to circumvent the law through technical loopholes in outdated regulations.

Yet three decades of scientific research suggest that present-dayGMOcontroversies are not grounded in scientific fact. For instance, despite frequent rumors aboutGMO-induced cancers, a scientific consensus has now formed to support the health and environmental safety of genetically modified crops for animal and human consumption. That proposition is supported by investigations of theU.S. National Academies of Science, Engineering, and Medicineas well as scientific panels including the American Association for the Advancement of Science, the American Medical Association, the European Commission, and National Academies of Science in Australia, Brazil, China, France, Germany, India, the United Kingdom, and other countries.

In its rulemaking process, the USDA should rely upon science and facts. With regard to crops and animals with DNA altered through gene editing, rulemakers ought to distinguish among ways that CRISPR technology may be used to edit genes. For instance, CRISPR technology can be used as a DNA construct that is incorporated into the DNA of plant or animal cells, or as a preassembled RNA and protein complex.

How gene editing is carried out matters, because some methods appear to fall within the disclosure requirements while others do not. The law definesbioengineered foodas food that contains genetic material modified through in vitro rDNA techniques. Thus, under the Disclosure Standard Acts statutory constraints, CRISPR food created using DNA constructs that are incorporated into plant or animal cells would likely fall under the mandatory disclosures.

However, food derived from rDNA-free CRISPR gene editing using transient preassembled RNA and protein complexes should be excluded from the bioengineered food definition because such complexes are degraded shortly after gene editing takes place and do not insert themselves into the target organism DNA.

The nuances of ever-evolving biotechnological innovation highlight the complexity of our regulatory system and the need to modernize it. The National Bioengineered Food Disclosure Standard Act is just one of the latest pieces of that regulatory patchwork to emerge. Rules establishing bioengineered food disclosures should be coherent and science-based. Gene editing that uses no foreign DNA, is more precise than conventional breeding methods, and causes genetic modifications already found in nature should not be subject to onerous disclosure standards.

Paul Enrquez is a lawyer and scientist currently doing research in Structural & Molecular Biochemistry at North Carolina State University. His work focuses on the intersection of science and law and has been featured in both legal and scientific journals. He explores rising legal and regulatory issues concerning genome editing in crop production in depth and makes policy recommendations in his recently published article CRISPRGMOs.

The views expressed by contributors are their own and not the views of The Hill.

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Genetically modified food is too advanced for its out-of-date regulations - The Hill (blog)

Stanford’s Final Exams Pose Question About the Ethics of Genetic Engineering – Futurism

In BriefThe age of gene editing and creation will be upon us in thenext few decades, with the first lifeform having already beenprinted. Stanford University questions the ethics of prospectivestudents by asking a question we should all be thinking about. Stanfords Moral Pickle

When bioengineering students sit down to take their final exams for Stanford University,they are faced with a moral dilemma, as well as a series of grueling technical questions that are designed to sort the intellectual wheat from the less competent chaff:

If you and your future partner are planning to have kids, would you start saving money for college tuition, or for printing the genome of your offspring?

The question is a follow up to At what point will the cost of printing DNA to create a human equal the cost of teaching a student in Stanford? Both questions refer to the very real possibility that it may soon be in the realm of affordability to print off whatever stretch of DNA you so desire, using genetic sequencing and a machine capable of synthesizing the four building blocks of DNA A, C, G, and T into whatever order you desire.

The answer to the time question, by the way, is 19 years, given that the cost of tuition at Stanford remains at $50,000 and the price of genetic printing continues the 200-fold decrease that has occurred over the last 14 years. Precursory work has already been performed; a team lead by Craig Venter created the simplest life form ever known last year.

Stanfords moral question, though, is a little trickier. The question is part of a larger conundrum concerning humans interfering with their own biology; since the technology is developing so quickly, the issue is no longer whether we can or cant,but whether we should or shouldnt. The debate has two prongs: gene editing and life printing.

With the explosion of CRISPR technology many studies are due to start this year the ability to edit our genetic makeup will arrive soon. But how much should we manipulate our own genes? Should the technology be a reparative one, reserved for making sick humans healthy again, or should it be used to augment our current physical restrictions, making us bigger, faster, stronger, and smarter?

The question of printing life is similar in some respects; rather than altering organisms to have the desired genetic characteristics, we could print and culture them instead billions have already been invested. However, there is theadditional issue of playing God by sidestepping the methods of our reproduction that have existed since the beginning of life. Even if the ethical issue of creation was answered adequately, there are the further questions ofwho has the right to design life, what the regulations would be, and the potential restrictions on the technology based on cost; if its too pricey, gene editing could be reserved only for the rich.

It is vital to discuss the ethics of gene editing in order to ensure that the technology is not abused in the future. Stanfords question is praiseworthy because it makes todays students, who will most likely be spearheading the technologys developments, think about the consequences of their work.

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Stanford's Final Exams Pose Question About the Ethics of Genetic Engineering - Futurism

Immortality crowned best at Italian film festival – Tehran Times – Tehran Times

TEHRAN -- Immortality by Mehdi Fard-Qaderi won the award for best feature movie at the 15th Ischia Film Festival on the Italian island on Saturday, the organizers announced.

The film was competing in the official section of the festival, which began on June 24.

A jury composed of Polish filmmaker Krzysztof Zanussi, Portuguese screenwriter Miguel Barros and German producer Dagmar Jacobsen picked Immortality for the courageous use of a single location in a single shot.

Beyond his mastery, we recognize that it is a well-written and recited movie whose purpose is to provide a unique fresco in modern Iran. What a success, the jury said in a statement.

Immortality, which is a one-shot feature film, tells the story of some strangers who have to spend a rainy night together on a train.

Photo: Director Mehdi Fard-Qaderi holds an award for his movie Immortality at the 15th Ischia Film Festival in Italy on July 1, 2017.

RM/YAW

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Immortality crowned best at Italian film festival - Tehran Times - Tehran Times

Gene Cloning Just Became A Thousand Times Easier – Wall Street Pit

Presently, the process of DNA sequencing to discover a genes function is a bit time-consuming because it has to be done one gene at a time. But with the invention of a team of researchers from Rutgers University-New Brunswick, Johns Hopkins University and Harvard Medical School, that process can now be considerably shortened as they have found a way to simultaneously clone thousands of genes.

The new technique is called LASSO cloning LASSO is an acronym for long-adapter single-strand oligonucleotide and through it, isolating thousands of DNA sequences can now be done at the same time. As a result, the new technology can supposedly expedite the creation of proteins the end product of genes which can in turn lead to faster discovery of new medicines and biomarkers for scores of diseases.

The technique is considered as quite an improvement over an existing method known as molecular inversion probes (MIPs), which can only capture about 200 bases of DNA. Raising this number to a thousand is especially significant because the typical size of a genes protein-coding sequence can reach up to thousands of DNA base pairs.

The technology works through a tool the team refers to as a LASSO probe. Using a number of these probes enables grabbing of target DNA sequences, similar with how a lasso (a rope) is used to round up cattle. What makes this special is the fact that with a single effort, the technique can grab thousands of DNA sequences at the same time.

In their proof-of-concept study, the team used their LASSO probes to simultaneously capture over 3,000 E. coli bacteria DNA fragments. They were successful in capturing around 95% of their gene targets. More importantly, the sequences were captured in such a way that allowed the researchers to observe and evaluate what the expressed proteins do.

As an added bonus, the team also helped solved a perennial problem in the genome sequencing field. As it is, genetic sequencing currently involves sequencing small fragments of DNA one at a time, then overlaying them in order to map out the entire genome. This doesnt just take time; its also harder to interpret and kind of prone to errors. With the LASSO probes, sequencing long fragments has now been made possible, which also translates to a faster and more accurate gene sequencing process.

As one of the researchers, Biju Parekkadan of the Rutgers University-New Brunswick, said: We think that the rapid, affordable, and high-throughput cloning of proteins and other genetic elements will greatly accelerate biological research to discover functions of molecules encoded by genomes and match the pace at which new genome sequencing data is coming out.

Going forward, the team is now working on improving the cloning process, building libraries and discovering the therapeutic proteins found in our genes.

The research was recently published in the journal Nature Biomedical Engineering.

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Gene Cloning Just Became A Thousand Times Easier - Wall Street Pit