How to Know When You Should Partner With a Nonprofit – Entrepreneur

For the current crop of startups, it's not just about creating the next big thing: Making an impact on the world is just as critical.

Related: How You Can Identify and Optimize Nonprofit Partnerships

That's why startup partnerships with nonprofit organizations are now more important than ever, and new opportunities are popping up every day. For instance, while malaria used to be the primary public health concern in Africa, GeekWire has reported that cancer may now be the continent's biggest health threat, according to recent data.

To combat this, Seattle nonprofit BIO Ventures for Global Health partnered in June with the African Organisation for Research and Training in Cancer, to create the African Access Initiative. The Initiative will bring in pharmaceutical and biotech companies, such as Pfizer and Takeda, to aid in the fight against cancer.

In a perfect world, a union between a startup and a nonprofit will always make sense. Complementary resources and common goals will also surely help, while timing is just as big a factor.

From the moment it opens its doors, a startup is running on borrowed time. Research by Statistic Brain has pointed to data showing that 25 percent of startups fail within the first year, 36 percent falter after two and 55 percent are dead by the end of year five.

Needless to say, then, every day counts for all young companies, including those that partner with nonprofits. The timing of any partnership must be strategic and help both sides get the most out of the union.

What do you see the fruits of your labor looking like a month from now? How about six months -- or years-- from now? Decide what success looks like now, and work toward creating the change your partnership hopes to see.

Through my company's partnership with the Clinton Global Initiative and the China Association for Integrative Medicine, we're providing monthly training sessions throughout China to teach locals how to tend to burn victims. The sessions provide immediate training and assistance in the communities that need it, while also building a long-term system of burn specialists who can service their chosen areas and serve as ambassadors for the company's joint venture and its chosen charitable organization.

Deliberate timing is vital for both sides of a startup-nonprofit partnership. It ensures that each can pull its own weight and operate at a high frequency.

Related: How Your Business Can Build Lasting Partnerships With Startups

Thirty percent of respondents in the Statistic Brain study cited "unbalanced experience or lack of managerial experience" as a reason for startup failure; and one of the subcategory reasons was too-rapid expansion, which occurs in a partnership when one or both partners are not ready. This is why it's so important to evaluate your company's financial and structural status to make sure your startup is healthy enough to join hands with a nonprofit.

Assuming you've found that perfect nonprofit, here are three questions to ask yourself to make sure the timing is right:

1. Where do we stand financially? Take the temperature of most failed startups, and you'll find that finances played a hand in a good chunk of their respective downfalls. Forty-six percent of the Statistic Brain respondents listed "incompetence" as the reason for startup failures, with reasons such as "emotional pricing" and lack of knowledge in pricing and finances named as factors.

When entering any partnership -- especially one involving a nonprofit -- ensure that your finances can stand up. Determine whether you're on solid enough ground to donate both time and your young company's scant financial resources. The point of that donation: to help a nonprofit that may also be trying to make its mark but is not as focused as you are, on finances.

2. Are we structurally sound? Money is one factor, albeit an important one, for determining how ready your startup is for a nonprofit teammate. But what about the other aspects of your company's health? In other words, do you have the personnel, work capacity and other support in place to make sure both parties benefit from this union?

Be strategic when entering a partnership, and make sure your company is equipped to handle the load. Strategic timing helps companies understand how a partnership could contribute to both organizations' health, in terms of size and scalability. For example, a small startup collaborating with a large nonprofit could find itself disregarded by others in the space despite heavy contributions to the partnership. This is especially true if the nonprofit's mission isn't updated to reflect the partnership's new objectives.

3. Do both brands look good to the public? Strategic timing is crucial, but don't ignore circumstantial timing, which isn't controlled by individuals and companies, but instead by public opinion. Ensure that your company and its potential nonprofit partner have solid public images so that a bad press story or a single indiscretion won't cast a poor light on your brand or its efforts.

Once that's determined, figure out where your respective brands complement each other. Brand alignment is key for building partnerships, so understand how your mission coincides with that of your potential nonprofit partner. To understand how you can help, understand the needs of your preferred nonprofits and identify gaps in their assistance.

Still unsure about the goal you want to focus on? Check the U.N.'s website and review its 17 sustainable development goals to see whether one fits with your company's current mission statement. From there, perform an internal review to see how your partnership could take advantage of existing infrastructures. Pursuing relevant, timely causes will help ensure that your efforts go to those which need it most and that your startup makes the most of its limited time and resources.

Related: Even Social Entrepreneurs Need to Meet Their Goals

A startup/nonprofit partnership can be great for all parties involved, but it must be initiated at the right time. Ask the questions that get to the core of what your company -- and its potential philanthropic partner -- represent in order to determine whether now is the time to make things official.

Kevin Xu is the CEO of MEBO International, a California- and Beijing-based intellectual-property management company specializing in applied health systems. He also leads Skingenix, which specializes in skin organ regeneration and the resear...

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How to Know When You Should Partner With a Nonprofit - Entrepreneur

Global Nanotechnology Enabled Coatings for Aircraft Market 2017 … – Business Wire (press release)

DUBLIN--(BUSINESS WIRE)--The "Global Nanotechnology Enabled Coatings for Aircraft Market 2017-2021" report has been added to Research and Markets' offering.

The analysts forecast the global nanotechnology enabled coatings for aircraft market to grow at a CAGR of 15.46% during the period 2017-2021.

Global Nanotechnology Enabled Coatings for Aircraft Market 2017-2021, has been prepared based on an in-depth market analysis with inputs from industry experts. The report covers the market landscape and its growth prospects over the coming years. The report also includes a discussion of the key vendors operating in this market.

One trend in the market is nanotechnology in maritime warfare systems. There has been a growing emphasis on using nanotechnology for improving the capabilities of submerged and marine combat platforms among defense agencies worldwide.

The use of nanotechnology allows developers to design and manufacture micro-sensors that can be scattered on the ocean floor for detecting hostile enemy submarines.

One driver in the market is increased focus on reducing aerodynamic drag. Nanotechnology involves engineering at the molecular level to produce new materials with enhanced performance for a wide array of industries and purposes.

This is regarded as one of the most important sources of innovation in the coming decades and will have applications across a comprehensive array of industries.

Key vendors

Other prominent vendors

Key Topics Covered:

Part 01: Executive summary

Part 02: Scope of the report

Part 03: Research Methodology

Part 04: Introduction

Part 05: Market landscape

Part 06: Market segmentation by coatings types

Part 07: Geographical segmentation

Part 08: Decision framework

Part 09: Drivers and challenges

Part 10: Market trends

Part 11: Vendor landscape

Part 12: Appendix

Companies Mentioned

For more information about this report visit https://www.researchandmarkets.com/research/q2cxbg/global

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Global Nanotechnology Enabled Coatings for Aircraft Market 2017 ... - Business Wire (press release)

IVF babies grow up heavier and may have higher risk of obesity – New Scientist

Whats the weight?

Jenny Elia Pfeiffer/Getty

By Jessica Hamzelou

SINCE the first test tube baby arrived 39 years ago, an estimated 6.5 million children have been born thanks to IVF and similar techniques. But we are only just starting to learn about the long-term health of people conceived using assisted reproduction techniques (ART), who may have a higher risk of obesity in later life.

Today, 1 in every 30 babies in Japan is conceived by ART, says Tomoya Hasegawa of Tokyo Medical University. These babies are usually healthy, but tend to have a lower birth weight. Large studies that didnt look at conception method have previously found that low birth weight is linked to adult obesity and diabetes.

To investigate further, Heleen Zandstra of Maastricht Medical Centre, the Netherlands, and her team have been comparing the effects of using two different culture media to support the growth of early IVF embryos. Earlier they had found that one of these was associated with babies that were 112 grams lighter at birth than those beginning life in the other medium. Thats a big difference, considering babies only weigh about 3 kilograms, says Zandstra.

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Now the team have followed up on these babies at the age of 9, recording the height, weight and fat mass of 136 children, as well as blood pressure and heart rate.

They were surprised to find that, while children conceived using each type of culture medium were around the same height, the BMI of the group that had been lighter at birth was an average of 0.9 lower than those who had been heavier babies. There was a difference in weight of 2 kilograms, says Zandstra.

Given that heavier children are more likely to develop obesity later on, the results are worrying

However, both groups were heavier than average 9-year-olds living in similar circumstances, and had more abdominal fat. Given that heavier children are more likely to become obese later in life, the results are worrying, says Zandstra, who presented her findings at the annual meeting of the European Society of Human Reproduction and Embryology (ESHRE) in Switzerland in July.

At the same meeting, Hasegawa presented his analysis of 1830 children in Japan. His team found that babies conceived using ART were heavier than naturally conceived babies when they were born, but there was no real difference at 18 months. However, the ART children were heavier again at 6 years old. The results were surprising, says Hasegawa.

What this might mean for adult health in unknown. Louise Brown, the first person born via IVF, is only 39 we dont know yet what will happen to IVF-conceived people in their 50s, says Zandstra.

But people neednt be wary of fertility treatment. We know that IVF is safe, because we have so many children, says Arianna DAngelo, who coordinates the ESHRE group on safety in assisted reproduction. We shouldnt worry, but we should be doing more to monitor children. Studies might flag up problems later in life, says DAngelo.

This article appeared in print under the headline IVF babies grow up to be heavier

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IVF babies grow up heavier and may have higher risk of obesity - New Scientist

Yes, sperm counts may be dropping, but it’s not time to panic yet … – The Verge

The internet was abuzz about sperm last week, thanks to a new study that revealed an alarming drop in sperm counts for men in Western countries. Does this mean men are becoming infertile? Will we have problems having babies? Its not time to panic at least, not yet.

To be clear: the findings are worrisome. The researchers dug through thousands of studies from around the world, and found that for men living in Western countries sperm count has plummeted by between 50 and 60 percent since 1973. (Sperm count is the amount of sperm in the semen released in one ejaculation.) But that drop still leaves the average sperm count within a healthy, fertile range.

Does this mean were heading into a Children of Men type of situation? says John Amory, a professor and fertility expert at the University of Washington, who was not involved in the study. I doubt that very much, Im glad to say. Still, infertility can have a serious, and negative impact on peoples lives, and its important to nail down whether it is indeed on the rise, and why. It should be seen as a wake-up call, agrees Michael Eisenberg, a urologist at Stanford University, but not necessarily the end of days.

Scientists have been debating whether sperm count has been going down for about 25 years, ever since researchers in Denmark published a study in 1992 showing a 50 percent drop in sperm count between 1940 and 1990. Since the odds of fathering a child tend to increase with sperm quantity (although quality matters, too), a fall in sperm count could mean an overall drop in male fertility.

Some believed this frightening claim, suspecting that the ongoing decline might be triggered by smoking and exposures to pesticides or components of plastics leaching into our food and disrupting hormones. But others disputed it, believing that sperms disappearing act was a result of the different way scientists have counted and studied semen over the years.

Researchers led by Shanna Swan, a reproductive scientist at the Icahn School of Medicine at Mount Sinai, wanted to put the debate to rest. They screened more than 2,500 studies that reported sperm counts since 1973, filtering out papers that were too small, used dubious methods, or that specifically looked at infertile men. Instead, they picked studies that counted sperm the same way in semen collected from men who either didnt know if they were fertile, or who knew for certain that they were.

Then, they compared the results for men of the same age, from 1973 to 2011: the results show that for men living in Western countries, sperm concentrations and absolute sperm number have dropped between 52 and 59 percent. (Sperm concentration is the amount of sperm in a milliliter of semen; absolute sperm number is the amount in the total volume of a single ejaculation.) The findings were published in the journal Human Reproduction Update.

Heres why you shouldnt freak out: sperm concentration went from about 99 million sperm per milliliter of splooge in 1970 to 47 million sperm per milliliter in 2010. Theyre well within the fertile range, Amory says. Theyre falling from fertile to fertile. For reference, men can have a tougher time conceiving if sperm count falls below 40 million sperm per milliliter. The World Health Organization considers sperm concentrations less than 15 million sperm per milliliter of semen to be abnormally low.

But the study also didnt find any evidence that this decline was slowing down or stopping. That means that if sperm count continues to plummet, then we could see more men having problems conceiving. Its concerning its important we figure out whats going on, Swan says.

Thats because sperm counts are important for more than just fertility: sperm as the authors of the study put it are the tadpole-shaped canaries in the coal mine when it comes to health. Making sperm takes a complex series of events: it starts with producing hormones in the brain, which stimulates sperm production in the testicles. That sperm is then shuttled through a network of pipes, mixed with other ingredients, and shot out into the world. Its like a long chain of dominos, and if any have been knocked askew by, say, injury, infection, or any number of other unknown cases, they wont all fall neatly into place. So, if sperm counts are dropping, it could be a sign that something is damaging mens overall wellbeing. In fact, lower sperm counts have been linked to poorer health.

The current study couldnt get at exact causes. But its thought that if pregnant women are exposed to cigarette smoke, certain pesticides, and ingredients in plastics that can disrupt hormones, it may have long-term effects on a male fetuss future fertility. For adult men, obesity and smoking may also lower sperm counts although we dont know for certain.

This study is a start toward settling the debate, but there are still some caveats: men can produce different amounts of sperm even at different points throughout the day, for instance. And theres more to fertility than just number of sperm sperm wiggliness and shape, for example, are important, too.

To figure exactly whats going on, we need more research. If the Centers for Disease Control and Prevention were to actively collect data on semen over time, that could go a long way toward confirming a decline and helping researchers spot possible causes, Eisenberg says. Its concerning as a species, and it needs to be tracked more rigorously, he says. If its confirmed, we should be very concerned and find a way to stop it.

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Yes, sperm counts may be dropping, but it's not time to panic yet ... - The Verge

Newly Released Clinical Study in The Journal of Clinical Biochemistry and Nutrition Confirms AstaReal’s Natural … – Benzinga

AstaReal Inc. USA has today shared its findings of its newly published clinical study on skin health in The Journal of Clinical Biochemistry and Nutrition.

Burlington, New Jersey (PRWEB) July 28, 2017

AstaReal Inc. USA, the leading producer and most studied brand of natural premium Astaxanthin, has today shared the findings of its newly published clinical study in The Journal of Clinical Biochemistry and Nutrition, confirming its natural AstaReal Astaxanthin can maintain a healthy complexion through extrinsic stressors associated with seasonal change.

Using its own Astaxanthin products, the study determined that AstaReal's Astaxanthin has been shown to reduce damaging effects on the skin caused by environmental factors such as ultraviolet rays and dehydration from low humidity, both of which often lead to wrinkles and seasonal dryness.

Throughout the 16-week-long clinical study in Japan, which lasted from August through December when damaging environmental factors such as increased UV rays and low humidity were at their highest, AstaReal's strong antioxidant capabilities were tested amongst a group of 65 female participants taking either 6 mg or 12 mg of Astaxanthin once per day or placebo. For those who took the placebo, the parameters for skin moisture content and wrinkles significantly worsened over those 16 months, while the 6 mg and 12 mg AstaReal Astaxanthin groups were not affected by seasonal environmental stressors such as UVB and low humidity.

The study also showed that production of inflammatory cytokines were suppressed in epidermal keratinocytes where UV-B induced inflammation occurred, suggesting that natural Astaxanthin suppresses inflammation of the epithelium. Normally, inflammation of this layer of the skin induces the secretion of matrix metalloproteinase-1 (MMP-1), causing the decomposition of dermal collagen.

When AstaReal's research team incubated dermal fibroblasts in the secretory fluid of UVB-irradiated epidermal keratinocytes pre-treated with Astaxanthin, suppression of MMP-1 secretion was confirmed, suggesting that natural AstaReal Astaxanthin improves resilience to wrinkle formation.

Before and after the study, samples of participants' own keratinocytes were sampled to investigate their resilience to seasonal low humidity. Upon examination, the study showed that there was an increase in cytokines associated with low humidity in the placebo group and 6 mg AstaReal group, indicating inflammation occurred in response to seasonal low humidity. Those who took 12 mg oral doses of AstaReal Astaxanthin, however, showed no increase in cytokines, confirming the proactive beauty benefits for the skin in those taking AstaReal's premium natural Astaxanthin daily.

For more information on AstaReal Inc. USA, visit http://www.astarealusa.com.

For the original version on PRWeb visit: http://www.prweb.com/releases/2017/07/prweb14543933.htm

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Taylor succeeds Flynn as head of Notre Dame California – ND Newswire

Richard E. Taylor, professor of chemistry and biochemistry at the University of Notre Dame, has been named interim director of Notre Dame California. He succeeds Patrick J. Flynn, Duda Family Professor of Engineering, who served as interim director from July 2016 through June of this year. As of July 1, Flynn assumed the position of chair of the Universitys Department of Computer Science and Engineering.

Patrick J. Flynn

Among other accomplishments during Flynns tenure, Notre Dame California launched its Silicon Valley Semester (SVS), which allows a select group of Notre Dame juniors majoring in computer science and engineering to spend their spring semester living, studying, and working in Palo Alto. The SVS consists of both Notre Dame coursework and credit-bearing internships at companies including Kyndi, OpsPanda, Intuit, QuakeFinder, Stryker, and AT&T.

The academic hub for the program is the Notre Dame California facility. Opened in February, it is located in AT&Ts central office in downtown Palo Alto and represents ongoing collaboration between the company and the University. Flynn was instrumental in this process, as well.

Pat has brought to life the broad vision with which we founded Notre Dame California, said Thomas G. Burish, Notre Dames Charles and Jill Fischer Provost. Whether working with AT&T to plan and complete our facility in downtown Palo Alto, developing and then leading the inaugural Silicon Valley Semester, or tending to the myriad other responsibilities that come with launching a new program, he has been a true champion of this endeavor. I am grateful both for Pats leadership during such a formative stage and now for Richs willingness to advance our continued growth on the West Coast.

Richard E. Taylor

I look forward to serving the University in this new position and building upon the strong foundation created by the outstanding efforts of Pat Flynn, Taylor added. I am particularly interested in expanding the participation of Notre Dame undergraduate and graduate students in experiential learning opportunities and connecting Notre Dame faculty and research programs with California-based academic institutions and businesses.

Taylor received his Ph.D. from Rensselaer Polytechnic Institute and completed a postdoctoral fellowship at Stanford University before joining Notre Dames Department of Chemistry and Biochemistry in 1995.

Noted for his work in the synthesis of novel pharmaceutical compounds, Taylor continues to maintain an active research portfolio on campus at Notre Dame, where he played a key role in founding what is now the Boler-Parseghian Center for Rare and Neglected Diseases as well as the Warren Family Research Center for Drug Discovery and Development. He was acting director of the Warren Center prior to accepting the appointment at Notre Dame California and is currently program director of rare disease research and development there.

During his 20-plus years on the Universitys faculty, Taylor has also served as associate dean of research and graduate education in the College of Science and associate vice president for research.

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Taylor succeeds Flynn as head of Notre Dame California - ND Newswire

Clarifiying complex chemical processes with quantum computers – Phys.Org

Future quantum computers will be able to calculate the reaction mechanism of the enzyme nitrogenase. The image shows the active centre of the enzyme and a mathematical formula that is central for the calculation. Credit: Visualisations: ETH Zurich

Science and the IT industry have high hopes for quantum computing, but descriptions of possible applications tend to be vague. Researchers at ETH Zurich have now come up with a concrete example that demonstrates what quantum computers will actually be able to achieve in the future.

Specialists expect nothing less than a technological revolution from quantum computers, which they hope will soon allow them to solve problems that are currently too complex for classical supercomputers. Commonly discussed areas of application include data encryption and decryption, as well as special problems in the fields of physics, quantum chemistry and materials research.

But when it comes to concrete questions that only quantum computers can answer, experts have remained relatively vague. Researchers from ETH Zurich and Microsoft Research are now presenting a specific application for the first time in the scientific journal PNAS: evaluating a complex chemical reaction. Based on this example, the scientists show that quantum computers can indeed deliver scientifically relevant results.

A team of researchers led by ETH professors Markus Reiher and Matthias Troyer used simulations to demonstrate how a complex chemical reaction could be calculated with the help of a quantum computer. To accomplish this, the quantum computer must be of a "moderate size", says Matthias Troyer, who is Professor for Computational Physics at ETH Zurich and currently works for Microsoft. The mechanism of this reaction would be nearly impossible to assess with a classical supercomputer alone especially if the results are to be sufficiently precise.

One of the most complex enzymes

The researchers chose a particularly complex biochemical reaction as the example for their study: thanks to a special enzyme known as a nitrogenase, certain microorganisms are able to split atmospheric nitrogen molecules in order to create chemical compounds with single nitrogen atoms. It is still unknown how exactly the nitrogenase reaction works. "This is one of the greatest unsolved mysteries in chemistry," says Markus Reiher, Professor for Theoretical Chemistry at ETH Zurich.

Computers that are available today are able to calculate the behaviour of simple molecules quite precisely. However, this is nearly impossible for the nitrogenase enzyme and its active centre, which is simply too complex, explains Reiher.

In this context, complexity is a reflection of how many electrons interact with each other within the molecule over relatively long distances. The more electrons a researcher needs to take into account, the more sophisticated the computations. "Existing methods and classical supercomputers can be used to assess molecules with about 50 strongly interacting electrons at most," says Reiher. However, there is a significantly greater number of such electrons at the active centre of a nitrogenase enzyme. Because with classical computers the effort required to evaluate a molecule doubles with each additional electron, an unrealistic amount of computational power is needed.

Another computer architecture

As demonstrated by the ETH researchers, hypothetical quantum computers with just 100 to 200 quantum bits (qubits) will potentially be able to compute complex subproblems within a few days. The results of these computations could then be used to determine the reaction mechanism of nitrogenase step by step.

That quantum computers are capable of solving such challenging tasks at all is partially the result of the fact that they are structured differently to classical computers. Rather than requiring twice as many bits to assess each additional electron, quantum computers simply need one more qubit.

However, it remains to be seen when such "moderately large" quantum computers will be available. The currently existing experimental quantum computers use on the order of 20 rudimentary qubits respectively. It will take at least another five years, or more likely ten, before we have quantum computers with processors of more than 100 high quality qubits, estimates Reiher.

Mass production and networking

Researchers emphasise the fact that quantum computers cannot handle all tasks, so they will serve as a supplement to classical computers, rather than replacing them. "The future will be shaped by the interplay between classical computers and quantum computers," says Troyer.

With regard to the nitrogenase reaction, quantum computers will be able to calculate how the electrons are distributed within a specific molecular structure. However, classical computers will still need to tell quantum computers which structures are of particular interest and should therefore be calculated. "Quantum computers need to be thought of more like a co-processor capable of taking over particular tasks from classical computers, thus allowing them to become more efficient," says Reiher.

Explaining the mechanism of the nitrogenase reaction will also require more than just information about the electron distribution in a single molecular structure; indeed, this distribution needs to be determined in thousands of structures. Each computation takes several days. "In order for quantum computers to be of use in solving these kinds of problems, they will first need to be mass produced, thereby allowing computations to take place on multiple computers at the same time," says Troyer.

Explore further: Developing quantum algorithms for optimization problems

More information: Markus Reiher et al. Elucidating reaction mechanisms on quantum computers, Proceedings of the National Academy of Sciences (2017). DOI: 10.1073/pnas.1619152114

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Application of Nanomaterials in the Field of Medicine – Medical News Bulletin

There has been a growing interest in the different applications of nanomaterials in the field of medicine. An article published in Nanomedicine: Nanotechnology, Biology, and Medicine showed the ways in which Laponite, a synthetic clay made of nanomaterials, can be of use in clinical practice.

Current advances in technology have provided many opportunities to develop new devices that improve the practice of medicine. There has been a growing interest in the different applications of nanomaterials in the field of medicine.

An article published in Nanomedicine: Nanotechnology, Biology, and Medicine reviewed Laponite, a non-toxic synthetic clay composed of nanomaterials which has different uses in the field of medicine. Laponite can be used in drug delivery systems, as the synthetic clay protects substances from degradation in physiologic environments. Different experiments show that Laponite is effective not only in protecting drugs from degradation, but also in transporting and releasing drugs into the body. The degradation of Laponite in the physiologic environment also releases products which have biological roles, especially in bone formation.

Laponite has been shown to induce osteogenic differentiation of cells in the absence of other factors which are known to promote differentiation and cell growth. The application of nanomaterials in bioimaging has also been studied. In one experiment, Laponite was incorporated with gadolinum, a dye used in magnetic resonance imaging (MRI), resulting in brighter images and prolonged contrast enhancement for 1 hour post-injection. Laponite has also proven to be of use in the field of regenerative medicine and tissue engineering. This synthetic clay can elicit specific biologic responses, act as a carrier for biochemical factors, and improve the mechanical properties of scaffolds used for tissue growth.

In summary, nanomaterials and synthetic clays such as Laponite have many applications in the field of medicine. Although current published literature state no toxic effects on the human body, further studies are needed to assess safety before it can be applied to clinical practice.

Written By:Karla Sevilla

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CRISPR Pioneer Zhang Preaches Extra Caution In Human Gene Editing – Xconomy

Xconomy Boston

A leading genome-editing researcher is urging extra caution as drug companies race to turn the landmark technology he helped create into human medicine.

In a paper published today in Nature Medicine, Feng Zhang of the Broad Institute of MIT and Harvard and colleague David Scott argue that researchers should analyze the DNA of patients before giving them experimental medicines that alter their genes with the breakthrough technology CRISPR. The suggestion, among others in the paper, stems from a deeper look at the wide array of subtle differences in human DNA.

Zhang is a key inventor of CRISPR-Cas9, which describes a two-part biological system that slips into the nucleus of cells and irreversibly alters DNA. One part is an enzyme, natures molecular scissors, which cuts DNA. The second part is a string of ribonucleic acid (RNA) that guides the enzyme to the proper spot. In five years since its invention, CRISPR-Cas9 has become a mainstay of biological research, and researchers including Zhang (pictured above) have moved quickly to improve upon its components. His work is at the center of a long-running patent battle to determine ownership of the technology.

Zhang and Scotts recommendation taps into a long-running debate in the gene-editing field about off-target effectsthe fear of misplaced cuts causing unintended harm. Most recently, the FDA took up a similar issue at a meeting to assess a type of cell therapy, known as CAR-T, for kids with leukemia. The FDA highlighted the risk that the cells, which have certain genes edited to make them better cancer fighters, may cause secondary cancers long after a patients leukemia has been cured. (FDA advisors unanimously endorsed the therapys approval nonetheless.)

Some researchers say there should be near certainty that gene altering techniques wont go awry before testing in humans, caution that stems in part from gene therapy experiments in the U.S. and Europe nearly 20 years ago that killed an American teenager and triggered leukemia in several European boys.

While no medicine is risk-free, other researchers say the tools to gauge risk have improved.

Andy May, senior director of genome engineering at the Chan Zuckerberg Biohub in San Francisco, calls Zhang and Scotts recommendation for patient prescreening a good discussion point, but the danger is someone will pick up on this and say you cant push forward [with a CRISPR drug] until everyone is sequenced.

Its an extremely conservative path to take, says May, who until recently was the chief scientific officer at Caribou Biosciences, a Berkeley, CA-based firm in charge of turning the discoveries of UC Berkeleys Jennifer Doudna and her colleagues into commercial technology. (May was also a board member of Cambridge, MA-based Intellia Therapeutics (NASDAQ: NTLA), which has exclusive license to use Caribous technology in human therapeutics.)

Berkeley is leading the challenge to Zhangs CRISPR patents and last week filed the first details in its appeal of a recent court decision in favor of Zhang and the Broad Institute.

Zhang sees prescreening as a form of companion diagnostic, which drug companies frequently use to identify the right patients for a study. A whole genome sequencewhich costs about $1,000could filter out patients unlikely to benefit from a treatment or at higher risk of unintended consequences, such as cancer. In the long run, it could also encourage developers to create more variations of a treatment to make genome-editing based therapeutics as broadly available as possible, said Zhang.

Its well known that human genetic variation is a hurdle in the quest to treat genetic diseases either by knocking out disease-causing genes or replacing them with healthy versions. But Zhang and Scott use newly available genetic information to deepen that understanding. In one Broad Institute database with genetic information from more than 60,000 people, they find one genetic variation for every eight letters, or nucleotides, in the exomethat is, the sections of DNA that contain instructions to make proteins. (There are 6 billion nucleotides in each of our cells.) The wide menu of differences is, in effect, an open door to misplaced cuts that CRISPRs enzymes might be prone to.

Zhang and others are working on many kinds of enzymes, from variations on the workhorse Cas9, to new ones entirely. He and Scott found that the deep pool of genetic variation makes some forms of the Cas enzyme more likely than others to go awry, depending on the three-nucleotide sequence they lock onto in the targeted DNA.

Zhang and Scott write that CRISPR drug developers should avoid trying to edit DNA strings that are likely to have high variation. In their paper, they examine 12 disease-causing genes. While more common diseases, such as those related to high cholesterol, will contain higher genetic variation because of the broader affected population, every gene, common or not, contains regions of high and low variation. Zhang and Scott say developers can build strategies around the gene regions they are targeting.

For example, going after a more common disease might require a wider variety of product candidates, akin to a plumber bringing an extra-large set of wrenches, with finer gradations between each wrench, to a job site with an unpredictable range of pipe sizes.

CRISPR companies say they are doing just that. We have always made specificity a fundamental part of our program, says Editas Medicine CEO Katrine Bosley. Zhang is a founder of Editas (NASDAQ: EDIT), which has exclusive license to the Broads Next Page

Alex Lash is Xconomy's National Biotech Editor. He is based in San Francisco.

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IMMORTALITY & RESURRECTION, INC. – Giza Death Star

Just when you thought the aspirations and plans of modern science couldn't possibly become more diabolical (or, if one prefer, sacrilegious), an article comes along to renew your hope that the world continues on its path of normalcy, and that many scientists are, indeed, just as wild-eyed-nuts as you always thought them to be. And this week, apparently many people were relieved and reassured that the mad scientist is not a thing of the past or a species that died out, but a real, living creature deserving of our awe and respect. Ms. M.W. and many others found this, and shared it, doubtless because they were concerned that I was losing hope that there were no more mad scientists:

Could we soon REVERSE death? US company to start trials 'reawakening the dead' in Latin America 'in a few months' - and this is how they'll do it

Way back when I first started writing about these strange topics in The Giza Death Star, I made the observation that physical immortality might not be such a good thing, without a commensurate and corresponding improvement in human spirituality and morality. In this, I took my cue from an ancient Greek Church Father named St. John Chrysostom, who warned about the same thing, and who stated that it was death, in fact, that formed the crucial condition for the possibility of human repentance and a change of mind, for it cut off further progress in evil. Taking this as my cue, in the final pages of that book, I asked people to imagine if such immortality were possible, or even a dramatically extended life span were possible - both of which are now being openly discussed and touted in serious and not-so-serious literature - what it might mean for the resulting civilization? One thing that would result, I pointed out, was a vastly expanded and accelerated scientific and technological development. One individual would, in such a condition, be able to learn and to master several academic disciplines, not just one.The explosion of technology and science would dwarf anything we have seen thus far. But the other consequence would be for moral progress. Imagine, I said back then, an Albert Schweitzer having not a century, but centuries or even millennia to do good things, or, conversely, a Mao Tse-Tung, a Josif Stalin, a Pol Pot or an Adolf Hitler, having that long to "perfect their progress in evil," and one gets a clear picture of the sharp moral contradictions such a society would be in. And please note: this problem is not a problem that, to my knowledge, is receiving anything close to the attention it needs in the transhumanism-virtual immortality community. The sole focus is on the science; if we can do it, we should do it.

Now we have this:

Bioquark, a Philadelphia-based company, announced in late 2016 that they believe brain death is not 'irreversible'.

And now, CEO Ira Pastor has revealed they will soon be testing an unprecedented stem cell method on patients in an unidentified country in Latin America, confirming the details in the next few months.

To be declared officially dead in the majority of countries, you have to experience complete and irreversible loss of brain function, or 'brain death'.

According to Pastor, Bioquark has developed a series of injections that can reboot the brain - and they plan to try it out on humans this year.

They have no plans to test on animals first.

...

The first stage, named 'First In Human Neuro-Regeneration & Neuro-Reanimation' was slated to be a non-randomized, single group 'proof of concept' study.

The team said they planned to examine individuals aged 15-65 declared brain dead from a traumatic brain injury using MRI scans, in order to look for possible signs of brain death reversal.

Specifically, they planned to break it down into three stages.

First, they would harvest stem cells from the patient's own blood, and inject this back into their body.

Next, the patient would receive a dose of peptides injected into their spinal cord.

Finally, they would undergo a 15-day course of nerve stimulation involving lasers and median nerve stimulation to try and bring about the reversal of brain death, whilst monitoring the patients using MRI scans.

Light, chemistry, and stem cells and DNA. If one didn't know any better, one would swear one was looking at the broad chronological progression of Genesis 1.

But I digress.

The problem here is, one notices, the almost complete avoidance of the moral question. Let's assume the technology works and that one can, literally, resurrect the dead scientifically. And let us assume the project reaches the stage of perfection envisioned by the Russian Cosmists, like Nikolai Fedorov. The cosmists, recall, want to extend the resurrection-by-science principle to the entire history of one's ancestors. But should this occur, then what about resurrecting people like Stalin, Mao, or Hitler? The sad truth is, some people still "revere" those twisted and murderous people as heroes. The sad truth is, some people would attempt to do it, if given the means to do so.

But there's an even bigger problem. The entire project is predicated on the materialist assumption that "brain function equals the person." Regular readers here know that I have never subscribed to such a view, nor have I subscribed to the view, conversely, that there is no relationship between a person's "personhood" and the functions of their soul, which would include, of course, the functions of their will, intellect, emotions, and brain. It is, I suspect, a very complex phenomenon not neatly divided into tidy Cartesian dualisms, with numerous feedback loops between the two. This said, however, the problem arises then that the brain is not the creator of individuality, but rather, its transducer (and, if I may employ a more ancient version of the term, its traducer). Thus, the possibility arises that one might "revive" a brain, and traduce or transduce a different individual than one "recalls" being present prior to brain death. Already some psychologists have written - and published - papers suggesting that certain mental disorders such as bipolarity and schizophrenia might not be disorders in any standard sense, but rather a phenomenon where an individual is inhabiting two very different and parallel universes at the same time. In this they draw upon the many worlds hypotheses of qauntum mechanics.

In short, for my money, I have no doubt that ultimately, some sort of "scientific" resurrection technique might be possible. But I suspect it will be a Pandora's box of spiritual phenomena which, once opened, will be difficult if not impossible to close again, and that before we open it, we should give lengthy, and due consideration to all the moral problems it will engender.

See you on the flip side...

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IMMORTALITY & RESURRECTION, INC. - Giza Death Star

Immortality, the Elixir of Life and the Food of the Gods …

When we look into the accounts of many different mythologies and religions, it becomes clear that the gods are either immortal or live a life of many thousands of years. What is rarely mentioned is the fact that in ancient religious texts there is reference to their immortality or longevity being connected to a specific kind of food that only the gods are allowed to eat. The gods were required to eat this food regularly to maintain immortality, power and strength. Many references also refer to the fact that if mortals ate this food, they would also become immortal like the gods. So let us explore the mythology surrounding this Elixir of Life

One of the main references to the food of the immortals can be found in Greek mythology. It is written in the stories of the Greek gods that ambrosia and nectar was the food and drink of the immortal gods and this first appears in the Greek mythology relating to the birth of Zeus. Before the invention or discovery of ambrosia and nectar by the gods, it was written that they would feed by sniffing the vapours of their dead enemies, as if they would feed from the energy of the dead souls.

Ambrosia was said to come from the horn of a magical goat named Amalthea, the foster-mother of Zeus. The horns of Amalthea provided a limitless supply of ambrosia but were also capable of producing any kind of food for any kind of living being. White holy doves would carry the ambrosia and a large eagle with shiny wings would fly at an extraordinary speed through the sky where he would get the nectar and then bring it down to the baby Zeus.

When demigod Achilles was born, his mother would pour ambrosia over Achilles and he would become immortal, but because she held him around his heel that was the only part that remained mortal. This allowed Achilles to be killed later on by Paris.

It was said that ambrosia was used by the gods to cure diseases, fix scars, and make the body beautiful again. If dead people would be treated with ambrosia, their bodies would remain in perfect condition forever. In other references, we can see that ambrosia was abundant in the gardens of Hesperides. Hesperides were nymphs who tend to a blissful garden in the far western corner of the world, a place where ambrosia was brought to the God Zeus.

But the immortal food also appears in the Bible where we can see similarity between the gardens of Hesperides and the gardens of Eden, where according to the Old Testament, man was forbidden to eat the fruit from the Tree of Life:

And out of the ground the Lord God made to spring up every tree that is pleasant to the sight and good for food. The tree of life was in the midst of the garden, and the tree of the knowledge of good and evil, Genesis 2:9

When Adam and Eve ate from the forbidden Tree of Knowledge, it appears that God alerted other Gods to be on alert because man should not eat also from the Tree of Life and become immortal like them.

Then the Lord God said, Behold, the man has become like one of us in knowing good and evil. Now, lest he reach out his hand and take also of the tree of life and eat, and live forever, Genesis 3:22

Moving on to Zoroastrian and Vedic mythologies, we can see reference to a special drink consumed by the gods, known as Soma and Haoma respectively. This special drink was prepared by extracting the juices from the stalks of certain plants, which are unknown to us today. Drinking Soma and Haoma would give immortality. Idra, the leader of the Devas, and the God Agni, are mentioned in the Rig Veda to have been drinking large quantities of the immortal drink.

We have drunk Soma and become immortal; we have attained the light, the Gods discovered, Rig Veda 8.48.3

If we now move to Egyptian mythology and the legends of Thoth and Hermes Trismegistus, we will see that there are references to both of them drinking white drops, also referred to as liquid gold, which provided them with immortality. References about this can be found in the Quran (Sura 18; the Khidr) and in one of the Nag Hammadi texts.

In Sumerian texts, we have references to the Ninhursags milk, one of the seven great deities of Sumer, the goddess of fertility that is associated with a cow (similar to the magic goat Amalthea of the Greek mythology). The gods and the kings of ancient Sumer would drink from this milk to become strong and immortal. In the Epic of Gilgamesh, we also have reference to a thorny plant at the bottom of the ocean that would make someone immortal and this was kept as a secret of the gods.

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Immortality, the Elixir of Life and the Food of the Gods ...

Trauma course added to medical school curriculum – News from Tulane

Tulane University School of Medicine third-year students in surgery rotations practice bleeding-control techniques as part of a new trauma course. (Photo from Tulane School of Medicine)

When a gunman attacked members of Congress at a baseball practice in June, a lawmaker who served in Iraq was able to deliver critical aid to victims before emergency responders arrived. The veteran had learned bleeding-control techniques designed to save the lives of those critically wounded on the battlefield.

Now all third-year students at Tulane University School of Medicine will get similar training thanks to a new program launched by trauma surgeons. Students will be required to complete a "Stop the Bleed" course, designed by the American College of Surgeons Committee on Trauma, during their surgery rotation.

"We want to make sure anybody who graduates knows how to stop bleeding whether they have seen it in real life or not," said Dr. Rebecca Schroll, assistant professor of trauma and critical care, who is leading the program. "To our knowledge, we are the first medical school in the country to incorporate this course into the standard medical student curriculum."

The Stop the Bleed program was designed to teach police and first responders how to use tourniquets and other techniques to stop bleeding from gunshot wounds or other life-threatening injuries after an active-shooter or mass-casualty event. The idea to train first responders in trauma care was championed by legendary Tulane trauma surgeonDr. Norman McSwain.

Schroll hopes that students will pass the knowledge on to others after they graduate by becoming certified instructors.

"Our intention is that all Tulane graduates will be competent in bleeding-control techniques and can comprise a network of qualified instructors who can go out into communities to educate an exponentially expanding number of the lay public, who will be able to stop life-threatening bleeding and save lives.

Like this article? Keep reading: TUPD learns skills to save lives in active shooter events

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Trauma course added to medical school curriculum - News from Tulane

Uniting psychiatry and bioengineering to study brain disease – Varsity

A laboratory technique called optogenetics has emerged as one of the biggest scientific breakthroughs in recent history. Optogenetics involves the control of cells using light. When applied to neurons, this tool has the potential to cure blindness, treat Parkinsons disease, and relieve chronic pain.

Optogenetics can be used to control the activity of neurons in freely-moving mammals. Using the technique, scientists are able to study the natural mechanisms of how the brain works and the pathological changes implicated in brain disease.

Dr. Karl Deisseroth, a world leader in optogenetics, gave a talk at the Peter Gilgan Centre for Research and Learning on July 6 as this years Aser Rothstein Lecture Series speaker. Deisseroth is theD.H. Chen Professor of Bioengineering and of Psychiatry and Behavioural Sciences at Stanford University. Hisbackground in both psychiatry and bioengineering places him in a unique position to approach optogenetics.

Whats cool now is that we can control neurons and play in activity patterns just like a conductor conducting an orchestra and we can do this during complex behaviours and see what actually causes certain behaviour, such as memory cognitions, affective, or emotional states, Deisseroth said in an interview with The Varsity.

The initial concept of [past] experiments were relatively cheap and easy, but then actually making it all work in a behaving animal took about four to five years, he continued. I had to build the technology and test it and apply it and also help other people because it was a very new thing and a strange kind of thing to do in science.

Deisseroth sees optogenetics as a mature technology, but he believes there is always room for improvements, as he and his team are continuing to tweak it.

The next step really is to go beyond and integrate it with other methods so we can get to a deep understanding of those circuits, he said.

Computer science and artificial intelligence offer new capabilities in this field, and the challenge will be to bridge the gap between these fields and neuroscience. [This is] probably one of the most exciting places to be, but it needs people from all walks of life, and all kinds of disciplines its a really wide-open territory for smart people.

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Israel’s vital contributions to nanotechnology – ISRAEL21c

Yeshayahu Talmon is a chemical engineer and former director of the Russell Berrie Nanotechnology Institute (RBNI) at the Technion-Israel Institute of Technology, in Haifa. A frequent spokesman for the industry, he answers even laymens questions patiently and lucidly, and offers positive news about Israel as a nucleus for nanoscience.

Some basics about nanotechnology

Nanoscience is the science of everything that happens on that very small scale. Now, technology is being developed to take that science and apply it, says Talmon.

One example of applications we are working with at the Russell Berrie Nanotech Institute is carbon nanotubes. Carbon nanotubes are only one to two nanometers thick, but the single particle is extremely strong. And in some forms, they are very good electrical conductors, and they are lightweight . . . so in principle they could be the material of the future.

However, in most cases, we cannot use them as single nanoparticles, so somehow we have to spin fibers out of them, and this is a challenge. (Sometimes, although it all works very well on a basic scientific level, when you try to make it into a process, things become more complicated.)

Another example of how the technology is applied is graphene sheets. Graphite, of course, is what you have in your pencil. However, when graphite is dispersed into single layers of carbon atoms, it has mechanical and electrical properties that can be used to make interesting coatings, like for touch screens, for instance.

All touch screens now have some kind of conductors in them, and by using graphene, you can potentially make better, cheaper, longer-lasting coatings.

In 2010, the Nobel Prize in Physics was given to Andre Geim and Konstantin Novoselov, two scientists working on graphene, so this field suddenly became even more exciting than before.

There is also a very important interface between medicine and the nanosciences, starting with intelligent, sophisticated sensors, all the way to drug delivery.

At the Technion, we try to bring people from our faculty of medicine together with people from engineering and the basic sciences, in some cases to advise graduate students jointly, and to work on a medical or biological problem where scientists and engineers can help. Collaborations among the various scientific disciplines are crucial here.

Yeshayahu Talmon. Photo by Miki Koren, courtesy Technion-Israel Institute of Technology

The Technions Role in Nanotechnology

Israel joined the nano community early on. And the Technion formed the nanotechnology center in 2005, two years before anybody else here. I played a part in its formation, but the effort was primarily led by Professor Uri Sivan of the physics department, who was the first director of the Russell Berrie Nanotechnology Institute. (I took over in 2010.)

In a way, it was a pioneering effort not only for the Technion, but for the entire country, because it formed a model on which all the other institutes were formed, not so much in the structure, but much more in the emphasis and in the way they are supported.

We have recruited many new faculty members at the RBNI; each of them is excellent. Many of them spent a good number of years in the United States or in other places, but most are originally Israeli.

There is a lot of talk about bringing back Israelis from abroad. Weve had to lure them from places like Boston University, Stanford, UCLA its competitive. And then, when theyve made the decision to come to Israel, we have to compete with the other Israeli universities: the Weizmann Institute, the Hebrew University, Tel Aviv University, and so on.

Our government is trying to reverse the brain drain that we have experienced most acutely in the sciences, of course, because these are the people who are most sought-after by institutions outside Israel.

But there is a kind of snowball effect although we scientists prefer to call it a nucleation process! Once you form a nucleus, it grows and attracts more material to form a crystal. Good researchers are attracted to a good nucleus.

Further Resources:Israel National Nanotechnology Initiative>

Tel-Aviv University Center for Nanoscience and Nanotechnology>

Weizmann Institute of Science>

Lin Arison & Diana C. Stoll are the creatorsofThe Desert and the Cities Sing: Discovering Todays Israel, a treasure box that highlights Israels creative achievement and innovation.

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Israel's vital contributions to nanotechnology - ISRAEL21c

USDA Awards $4.6 Million in Nanotechnology Research Grants – The National Law Review

Since 1996, Carla Hutton has monitored, researched, and written about regulatory and legislative issues that may potentially affect Bergeson & Campbell, P.C. (B&C) clients. She is responsible for creating a number of monthly and quarterly regulatory updates for B&C's clients, as well as other documents, such as chemical-specific global assessments of regulatory developments and trends. She authors memoranda for B&C clients on regulatory and legislative developments, providing information that is focused, timely and applicable to client initiatives. These tasks have proven invaluable to many clients, keeping them aware and abreast of developing issues so that they can respond in kind and prepare for the future of their business.

Ms. Hutton brings a wealth of experience and judgment to her work in federal, state, and international chemical regulatory and legislative issues, including green chemistry, nanotechnology, the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), the Toxic Substances Control Act (TSCA), Proposition 65, and the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) program.

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USDA Awards $4.6 Million in Nanotechnology Research Grants - The National Law Review

Using Nanotechnology to Enhance the Properties of Everyday Materials – AZoM

Our understanding of the nanoscale world is continually developing. Aron Claeys, founder of Nanex, saw the potential of nanotechnology when the science was still in its infancy and recognised that nanoparticle based coatings could play a prominent role in extending the lifespan of materials such as leather and textiles. In addition to this Nanex now plan to start working on novel technologies that use nanoparticles to purify pollution in water and air and to prevent the spread of bacteria.

AZoM spoke to Aron about the history of Nanex, how he expects nanoscience to impact the world and Nanexs plans for the future.

I started Nanex because I had a keen interest in nanotechnology and how it could be used to improve the environmental issues we are facing. The field of nanotechnology was beginning to open up to the wider world and I was fascinated by it. I was amazed that when a material is reduced to the nanoscale it develops novel properties which are not observed at the microscale. These properties can sometimes be themselves useful, or often unwanted properties on the macro scale can be removed.

To me, it was obvious that nanotechnology was going to impact every industry there is. And of course, as a young person I was concerned about the growing strain that humanity is placing on the environment. I also saw all of the interest around green technology such as solar and clean energy systems and began to wonder how nanotechnology could be used to enhance these.

From that point on, I started to research nanotechnology on a very broad scale as, at this point, I didnt know which direction I was going to take my research in. I began working with some nanotechnology specialists who introduced me to the coatings industry. It was then that I realised that protective coatings which exploit nanotechnology could improve the sustainability, the durability and the quality of materials. These coatings provide a protective layer which can be anti-bacterial, withstand scratches, clean itself, can be easily cleaned without the use of heavy detergents or even any detergents at all!

Coating nanotechnology was already relatively advanced at this point and, having started from scratch and having limited resources, I saw this as a perfect starting point. We started working on new coating materials and products to develop for the market. After seeing that coatings for textiles and leathers were in high demand for both manufacturers and wholesalers we began to focus our efforts here.

Our research team started to experiment further on different types of nanoparticles and nanoparticles of different sizes. The size of the nanoparticles in the dispersion has a significant effect on the properties and chemistry of the solution we produce.

Weve now been developing our most recent range of products for the last nine months. Weve developed some advanced coatings that can improve the quality of leathers. We live in a society built on over-consumption where things no longer last we want our sprays to help goods last longer so people have more time to enjoy them. Our sprays also reduce the need to use detergent when washing clothes, reducing environmental impact.

Shutterstock | Volodymyr Plysiuk

We looked at different nanoparticles and how they reacted with different materials. We also researched traditional chemistry, such as water-repellent, stain release, and anti-bacterial effects.

We considered a wide range of nanoparticle technologies such as silicon dioxide, graphene, selenium and titanium dioxide and countless others its a continual research. We were evaluating the price, the quality and if the technology is ready for commercial use. We didnt want anything that was too niche and expensive. We wanted to make sure that we developed an accessible and affordable product which allowed everyone to feel the benefit.

In addition to the silicon dioxide and different sized nanoparticles we've also been testing ceramic particles, titanium dioxides and nanocrystals. Nanocrystals are really interesting as they can be crystallized to give increased hardness with specific UV blockers.

What types of properties are you aiming towards? Which properties is most desirable to add to your coating?

The most conventional are water and stain repellent properties, however we would like to add much more to that. We are already carrying out a lot of research. As I mentioned, some self-cleaning properties could be induced using a mixture of different nanoparticles, which are specific UV blockers, so the discoloration of clothes or shoes is reduced.

We are also investigating nanoparticles which can increase the hardness so the material can be more scratch proof or less prone to other forms of damage. These multi-functional properties are the way we're going right now.

Shutterstock | Kateryna Kon

For the time being we are currently focusing on the textiles and leather industries. However, were also seeing a lot of requests coming through from many different industries from the furniture and outdoor market to motorcycle and scooter manufacturers.

There are countless different areas in which Nanex coatings can be used but these markets will be the first that we explore as the demand is so high.

Weve already seen the coatings being used unconventionally. For example, we have a customer who is using the coatings in his artwork.

This artist is applying Nanex coatings on concrete using a stencil and once it has dried the coating becomes invisible. The artwork then becomes visible whenever it rains as the water will only follow where the coating has not been applied.

So far, weve only focused on one industry and we know that our technology has the scope to benefit so many different industries. We have the expertise and knowledge on our team to offer consultancy and work on joint development projects in a wide range of different areas. Were particularly interested in adding nanoparticles to construction materials or other composite materials to make them lighter, more efficient or to make them antibacterial.

We have ideas about how we could create biodegradable plastics which would reduce the excessive amount of waste humans are currently producing at landfills. Were also interested in seeing how nanoparticles can be incorporated into water and air purification technology.

We want to broaden the scope of our projects and want to stimulate, invite and inform other companies and industries to connect with us so we can work together to create next-generation materials that will make the planet better. Whether it is antibacterial packaging that extends the lifetime of food or if it is purification systems that reduces the spread of disease.

Shutterstock | Komsan Loonprom

In around two months we are going to be ready to do our big launch. It will be in Belgium at the start and then we will expand over Europe. We already have distributers in Asia so we expect to rapidly expand there.

Were going to launch in just a matter of months so keep your eyes peeled as things are going to get exciting.

From an early age, Aaron had a strong passion for entrepreneurship and how new ideas could be used to face the Worlds environmental challenges. Following years of self-study Aaron aimed towards creating a company that would help in building a more sustainable world. This is how Nanex was founded.

After seven years of intensive research Nanex developed several different coatings that utilised nanotechnology to improve the lifespan, and reduce detergent use, for commodity items such as shoes and clothes.

Aaron also offers his expertise as an environmental nanotechnology specialist both as a consultant and in joint development projects which aim towards environmental sustainability. These projects span from working with biodegradable materials, air and water purification and increasing energy efficiency.

Disclaimer: The views expressed here are those of the interviewee and do not necessarily represent the views of AZoM.com Limited T/A AZoNetwork the owner and operator of this website. This disclaimer forms part of the Terms and conditions of use of this website.

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Using Nanotechnology to Enhance the Properties of Everyday Materials - AZoM

Complaints of drinking, abusive behavior dogged USC medical school dean for years – Los Angeles Times

USC faced a choice five years ago: Keep Dr. Carmen Puliafito at the helm of the Keck School of Medicine or replace him.

As dean, Puliafito had brought in star researchers, raised hundreds of millions of dollars and boosted the schools national ranking all critical steps in USCs plan to become an elite research institution.

But what might have been an easy decision to renew his appointment was complicated by a groundswell of opposition from the medical schools faculty and staff.

Keck employees had complained repeatedly about what they considered Puliafitos hair-trigger temper, public humiliation of colleagues and perceived drinking problem, and many were adamant he be removed, according to current and former university employees as well as four letters of complaint reviewed by The Times.

Thomas Meredith / For The Times

USC President C. L. Max Nikias reappointed Puliafito to a second term in 2012.

USC President C. L. Max Nikias reappointed Puliafito to a second term in 2012. (Thomas Meredith / For The Times)

The people who spoke to The Times include a former USC administrator who handled personnel grievances, the medical schools former human resources director and prominent faculty members.

As a representative of USC, the Dean is an embarrassment to our School and the University, one Keck professor wrote in a March 2012 letter to the university provost.

Still, USC President C.L. Max Nikias opted to reappoint Puliafito, giving him a new five-year term with an annual salary of more than $1 million.

Puliafitos problems escalated. As The Times has reported, he partied with a circle of addicts, prostitutes and other criminals who said he used drugs with them, including on campus.

Late Friday, hours after the newspaper informed USC it was preparing to publish this story, Nikias sent a letter to the campus community acknowledging that the university received various complaints about Dr. Puliafitos behavior during his nearly decade-long tenure as dean.

Rebecca Sapp / WireImage

Then-Dean Carmen A. Puliafito, left, Dr. Inderbir Gill, actress Shirley MacLaine, actress Annette Bening and actor Warren Beatty at a USC event at the Montage Beverly Hills hotel in May 2009.

Then-Dean Carmen A. Puliafito, left, Dr. Inderbir Gill, actress Shirley MacLaine, actress Annette Bening and actor Warren Beatty at a USC event at the Montage Beverly Hills hotel in May 2009. (Rebecca Sapp / WireImage)

Nikias didnt provide details of the complaints but wrote that the university took disciplinary action against Puliafito and provided him professional development coaching. He didnt specify when.

The president also offered his first public account of the circumstances of Puliafitos abrupt resignation in the middle of the spring 2016 term, writing that he stepped down after Provost Michael Quick confronted him with new complaints about his behavior.

Do you have information about USC's former med school dean? We want to hear from you

Puliafito, now 66, was allowed to continue representing USC at official functions and remained on the faculty and hospital staff.

Nikias said Friday that at the time of the deans resignation, no university leader was aware of any illegal or illicit activities, which would have led to a review of his clinical responsibilities.

Over the last two weeks, Nikias and other university leaders have said they were stunned by the revelations about the former dean.

But interviews with two dozen of Puliafitos former colleagues suggest that complaints about his behavior were widespread and that at least some reached USCs upper management. The colleagues said Puliafitos conduct hurt morale and posed a risk to the schools reputation.

There were complaints about his demeanor, behavior and manner, said Jody Shipper, who headed USCs equity and diversity office for more than a decade. She left in 2015.

James Lynch, who was the medical schools human resources director for five years, said employees came to him fairly regularly about misbehavior by Puliafito, including rudeness and suspected drunk driving.

Many of the people who worked for him complained about the difficulty of just being around him, Lynch said.

Current Keck dean Dr. Rohit Varma told a gathering of medical school students this month that Puliafito had received treatment for alcoholism.

Puliafito did not respond to a request for comment. He previously told The Times he resigned of his own accord to pursue a job in private industry.

Concerns about him were contained in lengthy written evaluations in 2012 that were assembled to help determine Puliafitos fitness for a second term.

Everybody I knew trashed him, and he still got [re]hired, said former USC ophthalmology professor Dr. Kenneth L. Lu, who moved to UCLA in 2014.

Many faculty members and staff agreed to speak about Puliafito on the condition of anonymity, citing concerns over their careers. Since The Times report, USC has hired a crisis management firm to handle press inquiries and instructed employees at Keck not to speak to the media. The school also asked that doctors at an affiliate, Childrens Hospital of Los Angeles, refer all Times inquiries about Puliafito back to the university.

Several interviewed said they were speaking out of a desire to help the institution they loved. Most expressed shock at reports of the former deans drug use.

Robert Gauthier / Los Angeles Times

Faculty and staff members at the USC Keck School of Medicine complained repeatedly about Puliafito's behavior during his tenure as dean, a Times review found.

Faculty and staff members at the USC Keck School of Medicine complained repeatedly about Puliafito's behavior during his tenure as dean, a Times review found. (Robert Gauthier / Los Angeles Times)

In 2007, then-Provost Nikias, who became president three years later, chaired the committee that selected Puliafito, a renowned ophthalmologist, as medical dean. Many of his new colleagues initially found him brilliant and noted his easy rapport with patients and students. He struck them as extremely hardworking and committed to elevating Kecks national profile.

In my mind, anytime I saw him, he wanted to make this school grow, said Bill Watson, a former vice president for development who worked with the dean from 2010 to 2013.

He was prone to anger, however, many former colleagues said. Minor inconveniences sent him into screaming, red-faced rages at staff meetings, they said.

The F-word was in every other sentence, said one former professor. She said she heard a high-ranking Keck administrator vomit in the ladies room after one dressing-down by the dean.

Lynch, the former human resources director, confirmed that Puliafito upbraided that administrator on several occasions. It was certainly challenging, and she ultimately left, he said. Reached by The Times, the woman declined to comment.

One Keck physician said some on Puliafitos support staff consulted her professionally to cope with how the dean treated them.

I literally put people on medical leave for stress related to working with him, the physician recalled.

Others were concerned that he was drinking too much at USC events.

The dean was a heavy drinker, Lynch recalled. He was fond of martinis. He would have several.

He said he never saw Puliafito do anything particularly outrageous but fielded multiple complaints from a female staffer disturbed that he was driving home from the events at which hed been drinking.

She was concerned he might get in an accident and hurt himself or someone else, Lynch said. He didnt want to confront the dean because he thought it would be counterproductive, he said, but he told the woman, If you are concerned, why dont you mention it to him?

Lynch, who was human resources director from 2009 to 2014, said he encouraged faculty and staff to complain directly to Puliafito themselves and did not pass on Keck employees complaints to the university administration.

It never occurred to me to do it, he said.

While Puliafitos personal behavior was distasteful, Lynch said, he was an absolute genius who was improving the medical school.

Hes kind of a pain in the ass, but he gets results, he said, adding that he felt administrators shared that view.

One senior faculty member said he phoned the provosts office after an encounter in which Puliafito seemed to be intoxicated.

An administrator in the office who took down his complaint, he said, thanked him for making the report and assured him it would be reviewed at the highest level.

He said he was not told the outcome and assumed it was being handled confidentially.

Puliafitos behavior caused some of his colleagues to leave. The medical schools admissions dean, Erin Quinn, who had been at USC since the early 1980s, stepped down from a position that I loved in 2011 because I couldn't work under Dr. Puliafitos leadership team.

It had changed from previous deans and compromised my values, she said.

When Puliafitos first term was nearing an end, then-Provost Elizabeth Garrett asked Keck faculty to complete written evaluations of his tenure a standard university practice and, in the provosts words, a crucial part of our evaluation of a deans effectiveness in leading the school.

Puliafito submitted a 19-page self-evaluation in which he listed myriad accomplishments. He noted that he had raised more than $500 million in contributions, recruited prominent researchers from Harvard, Stanford and other prestigious schools and pushed Kecks ranking in U.S. News & World Report up five spots to No. 34.

Professors were given the option of completing an anonymous online survey or writing letters. Some wrote lengthy responses filled with specific examples of Puliafitos shortcomings and urged the administration to replace him, according to interviews.

The Times reviewed four of these evaluations.

His presence has created a very negative atmosphere at KSOM which has alienated a large number of faculty and chairs and created a siege mentality, in which faculty and staff are constantly worried about their welfare and ability to maintain a productive environment in which to work, one professor wrote.

Another longtime faculty member described the dean as unpredictable and given to erratic behavior.

A major, overarching problem at the KSOM is that the Deans lack of effective and collegial leadership have resulted in a very low level of faculty morale, the professor wrote.

A USC employee who has seen the faculty evaluations filed in 2012 said a large number were highly negative and detailed in their criticism of Puliafito. Many of the others highlighted his strengths and weaknesses. The overall feedback showed that he was a polarizing figure at the school, the employee said.

When Garrett announced in June 2012 that Nikias had rehired Puliafito, no one could believe it, another senior faculty member recalled.

In a letter to the faculty and staff, Garrett said she had discussed employees feedback with the dean, including the matters on which some of you believe he could pay additional attention or that may require a different approach.

I am certain he will move forward with your suggestions firmly in mind, she wrote.

Nikias declined to speak about the complaints made against Puliafito. Garrett left USC to become the president of Cornell University in 2015; she died last year.

Puliafitos conduct became even more troubling in his second term.

The Times investigation published earlier this month found that the dean spent long hours partying with a group of younger addicts, prostitutes and other criminals in 2015 and 2016, and brought some to his Keck office in the middle of the night.

USC colleagues recalled that, during the same period, Puliafito was often absent during working hours.

His staff would say, I dont know where the dean is. I will try to call his cellphone, said a university administrator who regularly had business with Puliafito.

Los Angeles Times

In a Friday night letter to the USC community, Nikias said Puliafito was put "on notice for being disengaged from his leadership duties" in November 2015.

In a Friday night letter to the USC community, Nikias said Puliafito was put "on notice for being disengaged from his leadership duties" in November 2015. (Los Angeles Times)

In November 2015, Provost Quick put Puliafito on notice for being disengaged from his leadership duties, Nikias wrote in his letter to the university community Friday.

In March 2016, the dean was with a 21-year-old woman in a Pasadena hotel room when she overdosed. The woman, Sarah Warren, told The Times she and Puliafito resumed using drugs as soon as she was released from the hospital.

A witness to the overdose phoned Nikias office March 14 and threatened to go to the press if the school didnt take action against the dean.

Nikias said in his Friday letter that two receptionists who spoke to the witness did not find the report credible and did not pass it on to supervisors.

Just a few days earlier, Nikias said, two university employees had come forward with separate complaints about the dean. They told Quick that Puliafito seemed further removed from his duties and expressed concerns about his behavior.

The Provost consulted with me promptly and, as a result, confronted Dr. Puliafito. He chose to resign his position on March 24, 2016, and was placed on sabbatical leave, the president wrote.

On the Keck campus, the timing of Puliafitos resignation on a Thursday in the middle of the school term with no advance notice seemed suspicious.

Everybody read it as cover story, said one senior faculty member. But, he added, there was a sense of relief.

Nikias and top USC officials honored Puliafito and praised his leadership a few months later at a campus reception. He continued to practice medicine at USC clinics.

In his Friday night letter, Nikias wrote that school officials didnt hear about the overdose until they received an unsubstantiated tip months after Puliafito stepped down as dean.

When we approached Dr. Puliafito about the incident, he stated a friends daughter had overdosed at a Pasadena hotel and he had accompanied her to the hospital, he wrote.

The president also said that in March, The Times did provide the university with detailed questions about, and a copy of a 911 recording from the Pasadena hotel incident. The recording was immediately referred to the Hospital Medical Staff, a committee that assesses clinical competency, Nikias said. In the 911 call, Puliafito describes himself as a doctor and the woman who had the overdose as his girlfriend.

The clinical competency committee determined that there were no existing patient care complaints and no known clinical issues, the president said.

It wasnt until The Times published its report that the school barred Puliafito from seeing patients and the state medical board launched an investigation of him.

On Friday, USCs crisis management firm released a letter from the chairs of 23 Keck departments. Addressed to USCs board of trustees, it affirmed their support for Nikias and Quick.

harriet.ryan@latimes.com

paul.pringle@latimes.com

matt.hamilton@latimes.com

sarah.parvini@latimes.com

adam.elmahrek@latimes.com

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Complaints of drinking, abusive behavior dogged USC medical school dean for years - Los Angeles Times

Medical school without the ‘sage on a stage’ – Washington Post

When the University of Vermont's medical school opens for the year in the summer of 2019, it will be missing something that all but one of its peer institutions have: lectures.

The Larner College of Medicine is scheduled to become the first U.S. medical school to eliminate lectures from its curriculum two years from now, putting it at the leading edge of a trend that could change the way the next generation of physicians learn their profession. (The medical school at Case Western Reserve University also has a no-lecture curriculum, established when the school opened in 2004.)

As anyone who has fallen asleep during a three-hour lecture class can attest, taking notes from a sage on a stage isn't as effective as other ways to absorb information, and research confirms this. The main reason for the traditional method seems to be, well, tradition; medical professors and other teachers have been doing it this way for centuries.

Retention after a lecture is maybe 10 percent, said Charles G. Prober, senior associate dean for medical education at the Stanford University School of Medicine. If thats accurate, if its even in the ballpark of accurate, thats a problem.

[First year doctors will be allowed to work 24-hour shifts]

Instead, medical schools across the country are experimenting with various forms of active learning" dividing students into small groups and having them solve problems or answer questions. In addition to improving retention, the approach more closely mimics the way work is accomplished in the real world.

It creates a stickier learning environment where the information stays with you better and you have a better depth of understanding, said William Jeffries, senior associate dean for medical education at Vermont's Larner College of Medicine, who is leading the effort.

The trend at medical schools is just part of a reform movement in the teaching of science, technology, engineering and mathematics (STEM) that emphasizes active learning instead of lecturing. Research supports the approach. When a team of researchers analyzed 225 studies that compared active learning and lectures in these fields, they found that test scores improved about 6 percent for students in active learning classes and that students in lecture classes were about 1.5 times more likely to fail than their counterparts in active learning classes.

[Heart doctors are listening for clues to the future of their stethoscopes]

Their 2014 analysis, published in the Proceedings of the National Academy of Sciences, also found that active learning is effective in all class sizes, though best in smaller groups.

The Larner school has moved most quickly toward the new approach, funded by a $66 million gift from Robert Larner, who graduated from the medical school in 1942. The money will be used to build facilities more suitable for small group instruction and train faculty in the new approach, Jeffries said.

Under the Larner model, students do their homework the night before class, rather than after it. They study the material in texts and online before a class, then take a short quiz to gauge how well they've learned it. After that, they break up into groups of six and attempt to solve a medical problem, then discuss their conclusions, led by a professor who acts as both a facilitator and an instructor, Jeffries said.

You're expected to learn the information prior to attending [a class]," he said. You do your homework first. Then you come and work, usually in groups, to solve a problem based on that knowledge.

The role change is not easy and sometimes it shows. Collin York, who will graduate from the school in 2020, said he strongly favors active learning. But the main complaint I have is when active learning sessions arent run particularly well, the atmosphere becomes a little chaotic. Classes can get noisy, and students' attention shifts quickly from problem to problem. Instructors sometimes struggle to maintain control, he said.

If the class is run well, you genuinely do not have to revisit that material, he said.

York said he also feels a responsibility to learn material before each class so he won't let his classmates down when it's time for problem solving. The real meat of these sessions, if you ask me, is really in the reasoning through different answers, he said.

With so much material including recordings of lectures now online, medical students are making the transition easier, Prober said.

When you go into a lecture in medical schools across the nation, you will find a minority of students actually present, he said. Medical students are adults. One generally believes that adults try to make decisions that are in their best interests. They have seemingly made the decision that it is not in the lectures.

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Medical school without the 'sage on a stage' - Washington Post

White Coat Ceremony Begins Medical School Journey | Michigan … – University of Michigan Health System News (press release)

One hundred and seventy-seven newly minted medical students were presented with crisp white coats bearing the University of Michigan logo and shiny stethoscopes on Saturday, July 29. The ceremony, held in Hill Auditorium, marks the official start of their medical school journey. The keynote speaker for the event is John Del Valle, M.D., A.G.A.F., F.A.C.P., professor and director of the internal medicine residency program.

During the ceremonys calling of the class, students came up on stage, announced their hometowns and undergraduate institutions, and were then presented with short white coats a symbol of their future profession, emphasizing the trust, humanity, and responsibility that comes with becoming a physician.

Marschall S. Runge, M.D., Ph.D., executive vice president for medical affairs and dean of the medical school, noted that This is an incredible time to be entering medicine and to begin your medical training and education. Medicine is changing rapidly, and the advances that will be possible in your careers will be amazing.

Class selected from record number of applications

The class was selected from a pool of nearly 7,000 applicants, according toSteven Gay, M.D., M.S, assistant dean for admissions for the medical school, the highest number of applications the school has ever seen.

The diverse class is 54 percent female and 19 percent from backgrounds traditionally underrepresented in medicine. The majority come to medical school after gaining experiences beyond college.

As our educational programs continue to evolve, this incoming class is truly remarkable for their potential to become leaders and change agents in health and science, says Rajesh Mangrulkar, M.D., associate dean for medical student education. This is the vision we have set for the new curriculum.

The incoming class will be immersed in the clinical care world of Michigan Medicine from the beginning. Theyll develop an understanding of the immense importance of teamwork while they engage in inter-professional education experiences with students enrolled in U-Ms other health professions schools. In addition, as the first class with a capstone project graduation requirement, they will receive enhanced training in leadership and have the opportunity to demonstrate their impact in medicine through one of eight scholarly concentrations, called Paths of Excellence.

Read one incoming medical students story about working alongside her U-M heart doctor dad.

For more about the curriculum, visithttps://medicine.umich.edu/medschool/education/md-program/curriculum (link is external).

More facts about this years incoming class:

To see the full 2017 entering class profile, visit https://medicine.umich.edu/medschool/education/md-program/our-community/students-faculty/admitted-class-profile.

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White Coat Ceremony Begins Medical School Journey | Michigan ... - University of Michigan Health System News (press release)

Explainer: How CRISPR works – Science News for Students

(for more about Power Words, clickhere)

applicationA particular use or function of something.

base (in genetics) A shortened version of the term nucleobase. These bases are building blocks of DNA and RNA molecules.

biologyThe study of living things. The scientists who study them are known as biologists.

Cas9An enzyme that geneticists are now using to help edit genes. It can cut through DNA, allowing it to fix broken genes, splice in new ones or disable certain genes. Cas9 is shepherded to the place it is supposed to make cuts by CRISPRs, a type of genetic guides. The Cas9 enzyme came from bacteria. When viruses invade a bacterium, this enzyme can chop up the germs DNA, making it harmless.

cellThe smallest structural and functional unit of an organism. Typically too small to see with the naked eye, it consists of watery fluid surrounded by a membrane or wall. Animals are made of anywhere from thousands to trillions of cells, depending on their size. Some organisms, such as yeasts, molds, bacteria and some algae, are composed of only one cell.

chemicalA substance formed from two or more atoms that unite (become bonded together) in a fixed proportion and structure. For example, water is a chemical made of two hydrogen atoms bonded to one oxygen atom. Its chemical symbol is H2O.

CRISPRAn abbreviation pronounced crisper for the term clustered regularly interspaced short palindromic repeats. These are pieces of RNA, an information-carrying molecule. They are copied from the genetic material of viruses that infect bacteria. When a bacterium encounters a virus that it was previously exposed to, it produces an RNA copy of the CRISPR that contains that virus genetic information. The RNA then guides an enzyme, called Cas9, to cut up the virus and make it harmless. Scientists are now building their own versions of CRISPR RNAs. These lab-made RNAs guide the enzyme to cut specific genes in other organisms. Scientists use them, like a genetic scissors, to edit or alter specific genes so that they can then study how the gene works, repair damage to broken genes, insert new genes or disable harmful ones.

developmental(in biology) An adjective that refers to the changes an organism undergoes from conception through adulthood. Those changes often involve chemistry, size and sometimes even shape.

DNA(short for deoxyribonucleic acid) A long, double-stranded and spiral-shaped molecule inside most living cells that carries genetic instructions. It is built on a backbone of phosphorus, oxygen, and carbon atoms. In all living things, from plants and animals to microbes, these instructions tell cells which molecules to make.

engineeringThe field of research that uses math and science to solve practical problems.

fieldAn area of study, as in: Her field of research was biology. Also a term to describe a real-world environment in which some research is conducted, such as at sea, in a forest, on a mountaintop or on a city street. It is the opposite of an artificial setting, such as a research laboratory.

fluorescentCapable of absorbing and reemitting light. That reemitted light is known as a fluorescence.

gene(adj. genetic) A segment of DNA that codes, or holds instructions, for producing a protein. Offspring inherit genes from their parents. Genes influence how an organism looks and behaves.

genomeThe complete set of genes or genetic material in a cell or an organism. The study of this genetic inheritance housed within cells is known as genomics.

muscleA type of tissue used to produce movement by contracting its cells, known as muscle fibers. Muscle is rich in a protein, which is why predatory species seek prey containing lots of this tissue.

mutation(v. mutate) Some change that occurs to a gene in an organisms DNA. Some mutations occur naturally. Others can be triggered by outside factors, such as pollution, radiation, medicines or something in the diet. A gene with this change is referred to as a mutant.

nucleusPlural is nuclei. (in biology) A dense structure present in many cells. Typically a single rounded structure encased within a membrane, the nucleus contains the genetic information.

organ(in biology) Various parts of an organism that perform one or more particular functions. For instance, an ovary is an organ that makes eggs, the brain is an organ that interprets nerve signals and a plants roots are organs that take in nutrients and moisture.

palindrome (adj. palindromic) A word, a name or a phrase that has the same ordering of letters when read forwards or backwards. For instance, dad and mom are both palindromes.

proteinCompoundmade from one or more long chains of amino acids. Proteins are an essential part of all living organisms. They form the basis of living cells, muscle and tissues; they also do the work inside of cells. The hemoglobin in blood and the antibodies that attempt to fight infections are among the better-known, stand-alone proteins. Medicines frequently work by latching onto proteins.

RNAA molecule that helps read the genetic information contained in DNA. A cells molecular machinery reads DNA to create RNA, and then reads RNA to create proteins.

tag(in biology) To attach some rugged band or package of instruments onto an animal. Sometimes the tag is used to give each individual a unique identification number. Once attached to the leg, ear or other part of the body of a critter, it can effectively become the animals name. In some instances, a tag can collect information from the environment around the animal as well. This helps scientists understand both the environment and the animals role within it.

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Explainer: How CRISPR works - Science News for Students