The Latest Trends in Skin, Beauty, and Wellness Offered by Michigans Rejuvenation Experts

Published: March 28, 2017

- A D V E R T I S E M E N T -

Always at the forefront of innovation in beauty and wellness, FACE and Cutler Integrative Medicine have joined to form the ultimate state-of-the-art, award-winning rejuvenation destination. The founders, Dr. Doug Cutler and Holly Cutler, have brought their naturopathic medical and esthetic backgrounds together to merge their expertise in inside-out anti-aging.

Almost two decades ago, Holly Cutler, also known as Americas Skin Saint, rebuilt her own skin, which had been disfigured by cystic acne. Since then, she has created one of the most extensive rejuvenation clinics in the U.S., offering more than 30 laser and facial machines, liquid face-lifts, vaginal rejuvenation, and body makeovers. With her innovative Skin Management Model and her one-hour transformations, Cutler has helped thousands of people who were not satisfied elsewhere. She has been a featured expert on FOX, CBS, NBC, ABC, and The Doctors Show, and has appeared on magazine covers and in several publications. Cutler has now launched her own highly anticipated and innovative skincare product line to help people all over the country who may not be able to access the services at her clinic. She is also anticipating the publication of her new book, No Filters Needed, a guide to enjoying the best skin possible for years to come.

The wellness division, headed by Dr. Doug Cutler, a licensed naturopathic physician, finds the root cause of imbalances in the body to create overall well-being from the inside out. His state-of-the-art clinic incorporates natural elements, and air and water purification systems, and is home to one of the most advanced detoxification clinics in the country. Dr. Cutler is the only doctor in Michigan who has the most advanced training in environmental medicine and genetic polymorphisms. His specialties include integrative medicine; anti-aging medicine; botanical medicine; detoxification therapies; nutrition, mental, and neurological conditions; womens disorders; childrens health; and more.

Dr. Cutler recently launched his new ClubIV, one of the only FDA/USP-compliant IV/IM

(intravenous/intramuscular) nutrient therapy clinics in Michigan. The advanced nutrient formulas are customized to increase energy, improve sleep, optimize immune function, recover cellular homeostasis, promote healing and recovery, reduce stress and anxiety, support weight loss, and much more. There is no comparison to the superior potency of nutrients delivered via IV/IM therapy. The dose bypasses the gastrointestinal system and is delivered directly into the bloodstream, so results are fast allowing you to feel better, sooner.

Most people can benefit from IV/IM therapy. At your first visit, an evaluation is conducted to determine which combination of vitamins, minerals, and other nutrients will work best for you.

The range of therapies includes anti-aging, anti-inflammatory, antioxidant, detoxification, endocrine, hydration, metabolism, recovery, and wellness. The dedicated infusion room is relaxing and peaceful; during your IV session you may experience local warmth, an increase in energy, or a deepening sense of calm and well-being.

Dr. Cutler is a member of the American Association of Naturopathic Physicians, the Michigan Association of Naturopathic Physicians, the American College for Advancement in Medicine, and the Pediatric Association of Naturopathic Physicians, and he is the board director for the Naturopathic Academy of Environmental Medicine.

As rejuvenation experts, the team of Dr. Doug Cutler and Holly Cutler can enhance your health, improve your overall quality of life, and keep you looking youthful for years to come.

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FACE Forward - Hour Detroit Magazine

Forget the Fountain of Youth; scientists are closer than ever to creating a safe and effective anti-aging drug, its been revealed.

Through a series of experiments on mice, researchers from Harvard Medical School and the University of New South Wales School of Medicine in Australia have discovered an essential clue as to how our cells repair damaged DNA. This is important because the bodys inability to mend DNA can result in age-related deterioration, claim the scientists.

They go on to say that when humans are young, they have great amounts of the DNA-repairing protein PARP1. As we age, however, another protein called DBC1 clings to it, rendering it impossible to finish its recon work. This makes it increasingly difficult for our systems to fix broken DNA.

In their study, the researchers fed old mice a molecule called NMN. The mice metabolized it into a signalling molecule called NAD, which squeezed in between the PARP1 and DBC1 proteins and pushed them apart. The DNA-repairing protein was then able to work effectively again, just like when the mice were younger.

This restored the DNA capacity of the old mouse back to a young mouse, and also to remove the DNA damage that accumulated in the tissue, said study author David Sinclair, Ph.D.

The scientists then exposed the mice to DNA-damaging radiation. The mice that were treated with the NMN molecule didnt show the usual effects of radiation, which include changes in white blood cell counts and hemoglobin levels.

While the scientists push that the NMN treatment has only been tested in mice and that the results may be different in people, they hope to begin human trials within six months.

This is the closest we are to a safe and effective anti-aging drug thats perhaps only three to five years away from being on the market if the trials go well, Sinclair said.

The drug could one day serve as a treatment for preventing DNA damage from aging, radiation and even chemotherapy.

h/t Mens Health

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Scientists Are One Step Closer To An Anti-Aging Drug - Civilized

Victoria Advocate

Fountain of Youth to celebrate 10th anniversary Victoria Advocate Le, a physician who specializes in internal medicine, aesthetic medicine and anti-aging medicine, moved into the shopping center about 10 years ago. "It's quite a journey, and we want to celebrate the contributions our business has brought to the ...

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Fountain of Youth to celebrate 10th anniversary - Victoria Advocate

Fort Lauderdale, FL Life Extension has partnered with Insilico Medicine to introduce Ageless Cell, the first supplement in its GEROPROTECT line to promote healthy aging by inhibiting cellular senescence.

Cellular senescence is a natural part of the aging process where cells no longer function optimally, affecting organ function, cellular metabolism, and the inflammation response. The accumulation of these senescent cells contributes to the process of aging. The Ageless Cell supplements inhibit the effects of cellular senescence by acting as geroprotectors, or interventions aimed to increase longevity and impede the onset of age-related diseases by targeting and inhibiting senescence-inducing pathways and inhibiting the development of senescent cells.

The partnership with Insilico Medicine allowed researchers to use deep learning algorithms to comb through hundreds of studies and thousands of data points a process that could have taken decades to identify four key anti-aging nutrients: N-Acetyl-L-Cysteine (NAC), myricetin, gamma-tocotrienol, and EGCG. These compounds target pathways that are known to contribute to or protect against the development of senescent cells.

Specifically, NAC upregulates signaling pathways that protect cells against oxidative stress, which promotes cellular senescence. It also reduces pathways that promote inflammation. Myricetin regulates a family of stress-responsive signaling molecules known to regulate aging in many tissues. It also promotes cell differentiation and self-repair. Gamma tocotrienol modulates the mevalonate pathway that controls cholesterol production, cancer promotion, and bone formation. And EGCG regulates the Wnt pathway that determines the fate of developing cells and also prevents sugar-induced damage to tissues, helping to suppress their pro-aging effects.

Clinical aging studies are extremely difficult, if not impossible, to perform at this time. Our collaboration with Insilico Medicine has allowed us to develop geroprotective formulations by using artificial intelligence to study very large data sets, said Andrew G. Swick, Ph.D., senior vice president of product development and scientific affairs for Life Extension.

Scientists found these four nutrients have various complementary and reinforcing properties to influence key anti-aging pathways and combat aging factors by modulating specific biological pathways. By rejuvenating near-senescent cells and encouraging the bodys healthy process for dealing with senescent cells, Ageless Cell turns back the clock at the cellular level, said Michael A. Smith, M.D., senior health scientist for Life Extension.

Alex Zhavoronkov, Ph.D., CEO of Insilico Medicine said, Together, these four natural compounds represent the beginning of the future anti-aging cocktails identified using artificial intelligence under expert human supervision.

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Life Extension and Insilico Medicine Use Artificial Intelligence to Develop Ageless - WholeFoods Magazine

HONOLULU--(BUSINESS WIRE)--Cardax, Inc. (Cardax) (OTCQB:CDXI) and the University of Hawaii (UH) announced today that Cardaxs proprietary astaxanthin compound, CDX-085, demonstrated an almost 90% increase in FOXO3 gene expression in mice (p=0.024).

This research was conducted by UH scientists Dr. Bradley Willcox, M.D., Professor and Director of Research at the Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii (JABSOM) and Principal Investigator of the NIH-funded Kuakini Hawaii Lifespan and Healthspan Studies, and Dr. Richard Allsopp, Ph.D., Associate Professor, Institute of Biogenesis Research at JABSOM.

Previously in humans, Dr. Willcox and colleagues discovered genetic variants of FOXO3 in humans that protect against aging (Willcox et al. Proc US Natl Acad Sci 2008).

This observation has since been replicated in >20 independent studies. At the American Heart Association Meeting in 2015, it was announced that the protective FOXO3 allele is strongly associated with reduced coronary heart disease mortality (p=0.00001) (AHA Meeting 2015) and later published in the leading gerontology journal (Willcox et al. J Gerontol Biol Med Sci 2016).

These results augment earlier findings in the C. elegans roundworm, a well-accepted model of aging, said Dr. Allsopp, where astaxanthin extended lifespan by 16-30%.

All of us have the FOXO3 gene, which protects against aging in humans, said Dr. Willcox. But about one in three persons carry a version of the FOXO3 gene that is associated with longevity. By activating the FOXO3 gene common in all humans, we can make it act like the "longevity" version. Through this research, we have shown that astaxanthin activates the FOXO3 gene.

This exciting new evidence provides yet another reason for physicians and patients to consider an astaxanthin dietary supplement such as ZanthoSyn as the foundation of an anti-aging, longevity program, said David G. Watumull, Cardax CEO.

About CDX-085

CDX-085 is the patented active ingredient of Cardaxs second generation product and like its first generation dietary supplement, ZanthoSyn, delivers astaxanthin to the blood stream with excellent absorption and purity, but in a more concentrated form, allowing higher doses per capsule and improved dosing convenience. Astaxanthin is a safe anti-inflammatory for general health that supports anti-aging and longevity.*

About FOXO3

FOXO3 is a member of the forkhead family of transcription factors. The human homolog in C. elegans, daf-16, has profound effects on longevity (Kenyon et al. A C. elegans mutant that lives twice as long as wild type. Nature 1993). Scientists led by Dr. Bradley Willcox, MD, member of the Cardax scientific advisory board, discovered a genetic variant of FOXO3 in humans that protects against aging (Willcox et al. Proc US Natl Acad Sci 2008). This observation has since been replicated in >20 independent studies. The protective FOXO3 allele (G allele) is associated with longevity with one G allele (GT genotype) doubling the odds to live to 100 and two G alleles (GG genotype) tripling the odds to live to 100. The protective FOXO3 allele is strongly associated with reduced coronary heart disease mortality (p=0.00001) (Willcox et al. AHA Meeting 2015) and the protective FOXO3 allele is strongly associated with reduced serum inflammatory markers (CRP and TNF-).

About Cardax

Cardax devotes substantially all of its efforts to developing and commercializing safe anti-inflammatory dietary supplements and drugs. Cardax is initially focusing on astaxanthin, which is a powerful and safe naturally occurring anti-inflammatory without the side effects of currently marketed anti-inflammatories. The safety and efficacy of Cardax's products have not been directly evaluated in clinical trials or confirmed by the FDA.

Safe Harbor

This release may contain certain forward-looking statements regarding our prospective performance and strategies within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. We intend such forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995, and are including this statement for purposes of said safe harbor provisions. Forward-looking statements, which are based on certain assumptions and describe future plans, strategies, and expectations of our company, are generally identified by use of words anticipate, believe, estimate, expect, intend, plan, project, seek, strive, try, or future or conditional verbs such as could, may, should, will, would, or similar expressions. Our ability to predict results or the actual effects of our plans or strategies is inherently uncertain. Accordingly, actual results may differ materially from anticipated results. Some of the factors that could cause our actual results to differ from our expectations or beliefs include, without limitation, the risks discussed from time to time in our filings with the Securities and Exchange Commission. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this release. Except as required by applicable law or regulation, we undertake no obligation to update these forward-looking statements to reflect events or circumstances that occur after the date on which such statements were made.

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Cardax Astaxanthin Compound CDX-085 Stimulates Anti-Aging ... - Business Wire (press release)

Posted on March 28, 2017, 6 a.m. in Sleep Brain and Mental Performance

New research explains how synapses in the cortex expand with daytime stimulation and shrink with sleep, resetting the brain and preparing it for the next day.

The need for, and mechanisms that drive sleep have consistently puzzled scientists. However, novel work from researchers at the University of Wisconsin School of Medicine and Public Health have tested their synaptic homeostasis hypothesis (SHY) for why animals need sleep. SHY theory describes a need for sleep

This four-year study by Luisa de Vivo and her colleagues, published in Science, supported the SHY theory. The SHY theory describes changes in synapses during waking and sleeping hours. Synapses are the junctions between two neurons, the larger the synapse, the stronger these two neurons can communicate - this ease of communication is how animals learn skills and make memories. Yet in order for brains to be pliable and learn new things, the synapses must shrink so these neural pathways can be activated again. SHY theory suggests that sleep allows these synapses to shrink.

According to SHY theory, sleep provides the perfect environment for the shrinking of synapses, allowing the brain to learn new things following day. The lack of stimulation while sleeping results in reduced activity between neurons, and therefore the distance between the neurons grows smaller allowing them to be activated with a weaker stimulation. This phenomenon allows brains to make new neural connections the following day, thereby allowing new memories to form and more efficient learning.

Testing SHY theory

Lead author Luisa de Vivo, along with her fellow researchers, tested their theory by measuring the size of synapses both before and after sleep. They utilized three-dimensional scanning electron microscopy to visualize and reconstruct the mouse brain and measured nearly 7000 synapses. They specifically looked at neurons involved in motor functions and sensory perception. The team then repeated this process after the mice had slept (making sure to note how long the mice had slept), and measured the synapses again.

The researchers found that the synaptic size correlated with the amount of sleep the mice had. The longer the mice had slept, the smaller the synapses had become with a few hours sleep resulting in the reduction by ~18 percent. Interestingly, the researchers only observed this phenomenon in ~80 percent of synapses and that the largest of synapses appeared not to be susceptible to the shrinking. They hypothesize that these synapses might not follow the pattern because those synapses are associated with stable, long-term memories or skills. These results support SHYs central tenant that the function of sleep is to renormalize synapse size that increases throughout the day. The researchers theorize that the shrinking of the synapses might be related to the lack of neurotransmitters during sleep, especially noradrenaline.

Giulio Tononi, head of the research group and Chair of Sleep Medicine at the University of Wisconsin believes the relevance of this works extends beyond mice, "extrapolating from mice to humans, our findings mean that every night trillions of synapses in our cortex could get slimmer by nearly 20 percent,"

The lack of stimulation that brains receive during sleep allows specific synapses to shrink, resulting in a brain that is ready to learn and create new memories the following day. This research provides rational to the large body of work that suggests animals learn skills better following a long sleep. Important synapses and neural pathways seem immune to this process of renormalization indicating that systems have evolved to preserve important memories and skills.

Ultrastructural evidence for synaptic scaling across the wake/sleep cycle Luisa de Vivo1, Michele Bellesi1,2, William Marshall1, Eric A. Bushong3, Mark H. Ellisman3,4, Giulio Tononi1,*, Chiara Cirelli1,* Science 03 Feb 2017: Vol. 355, Issue 6324, pp. 507-510 DOI: 10.1126/science.aah5982

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Brain Resets During Sleep - Anti Aging News

Posted on March 27, 2017, 6 a.m. in Cardio-Vascular Diagnostics

More than half of family doctors in Canada are still using manual devices, a dated technology that often leads to misdiagnosis.

A study by researchers at the University of Montreal Hospital Research Centre (CRCHUM) reports that over half of the Canadian family doctors are still making use of manual devices to measure blood pressure, which is a dated technology. Using a manual device to measure blood pressure often leads to misdiagnosis. Approximately 20% of those receiving treatment for hypertension don't actually have it and do not need medication.

Automatic electronic devices, called oscillometric devices, are available and are recommended by the Guidelines of the Canadian Hypertension Education Program (CHEP) as preferable to manual measurement.

However, in the spring of 2016, the team that conducted the survey among the Canadian family doctors found that 52% of the 769 who responded stated that they made use of a manual tensiometer to measure patients' blood pressure, and only 43% used an automatic device.

The lead author of the study, Janusz Kaczorowski, is a medical sociologist, a CRCHUM researcher, and a professor in the Department of Family and Emergency Medicine.

Manual measurement is acceptable if it is done properly, but that is not always the case. Kaczorowski stated that clinicians should use automatic devices because they are more precise and take several measurements. Automated measurement has an advantage because it eliminates white-coat syndrome, which is an artificially high blood pressure reading that is a result of being in a doctor's office.

To take blood pressure properly, a 12- to 15-minute period is required with the patient being left alone in a room while the measurement is taken. That is difficult because the average visit to a family doctor lasts only 10 minutes.

Blood pressure is the pressure that the blood exerts on the walls of arteries. Measured in an artery in the arm, blood pressure has two measurements: systolic as the heart contracts and diastolic as the heart relaxes. Normal pressure has the systolic pressure at below 140 mmHg and the diastolic pressure at below 90 mmHg. Above those numbers, a person is said to have high blood pressure or hypertension.

In Canada, one of every five adults suffers from hypertension, which is the greatest global risk factor for disability and death. Healthcare costs due to hypertension were evaluated at over $13 billion in 2010. Kaczorowski says that if blood pressure was measured incorrectly, there are considerable financial implications as well as possible side effects, which could be avoided.

The CHEP Guidelines state that modification of health-related behaviors is an efficient way of treating and preventing high blood pressure and reducing the cardiovascular disease risk. It is possible to lower one's blood pressure with a healthy diet, reduced intake of sodium, regular physical activity, moderate consumption of alcohol, tobacco product avoidance, and stress management.

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Is it Really High Blood Pressure? - Anti Aging News

Fort Lauderdale, FL Life Extension has partnered with Insilico Medicine to introduce Ageless Cell, the first supplement in its GEROPROTECT line to promote healthy aging by inhibiting cellular senescence.

Cellular senescence is a natural part of the aging process where cells no longer function optimally, affecting organ function, cellular metabolism, and the inflammation response. The accumulation of these senescent cells contributes to the process of aging. The Ageless Cell supplements inhibit the effects of cellular senescence by acting as geroprotectors, or interventions aimed to increase longevity and impede the onset of age-related diseases by targeting and inhibiting senescence-inducing pathways and inhibiting the development of senescent cells.

The partnership with Insilico Medicine allowed researchers to use deep learning algorithms to comb through hundreds of studies and thousands of data points a process that could have taken decades to identify four key anti-aging nutrients: N-Acetyl-L-Cysteine (NAC), myricetin, gamma-tocotrienol, and EGCG. These compounds target pathways that are known to contribute to or protect against the development of senescent cells.

Specifically, NAC upregulates signaling pathways that protect cells against oxidative stress, which promotes cellular senescence. It also reduces pathways that promote inflammation. Myricetin regulates a family of stress-responsive signaling molecules known to regulate aging in many tissues. It also promotes cell differentiation and self-repair. Gamma tocotrienol modulates the mevalonate pathway that controls cholesterol production, cancer promotion, and bone formation. And EGCG regulates the Wnt pathway that determines the fate of developing cells and also prevents sugar-induced damage to tissues, helping to suppress their pro-aging effects.

Clinical aging studies are extremely difficult, if not impossible, to perform at this time. Our collaboration with Insilico Medicine has allowed us to develop geroprotective formulations by using artificial intelligence to study very large data sets, said Andrew G. Swick, Ph.D., senior vice president of product development and scientific affairs for Life Extension.

Scientists found these four nutrients have various complementary and reinforcing properties to influence key anti-aging pathways and combat aging factors by modulating specific biological pathways. By rejuvenating near-senescent cells and encouraging the bodys healthy process for dealing with senescent cells, Ageless Cell turns back the clock at the cellular level, said Michael A. Smith, M.D., senior health scientist for Life Extension.

Alex Zhavoronkov, Ph.D., CEO of Insilico Medicine said, Together, these four natural compounds represent the beginning of the future anti-aging cocktails identified using artificial intelligence under expert human supervision.

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Life Extension and Insilico Medicine Use Artificial Intelligence to Develop Ageless Cell - WholeFoods Magazine