Author Archives: ev1

Q & A

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Hello sir,

I am a graduate of biochemistry with little knowledge about the business world.

I believe in being self-employed and, in view of this, I have this idea about investing in the auto industry. However, I have been having headaches on how to develop a business plan for this. I will be grateful if you can give me a guideline or highlight some key points on how I can come up with a business plan. I have already noted some points you made in the last two paragraphs of your article in The PUNCH of Wednesday, March 27. Thank you.

Adesanya A.

Dear Adesanya,

You will need an experienced hand to help you do a good business plan; as it is not a document that is done anyhow because the business plan is meant to serve as the template for the business. My advice is that when you find the person to help you do the business plan, please dont look for free service. Since you need useful information to make money from, you should be willing to exchange it for value. Also, the fee a good consultant may charge you may not be that cheap, therefore, you should be prepared to pay. It is part of your investment, which you want to make profit from. Regards.

Emmanuel

Dear Ola,

I agree 100 per cent with your view on economies of scale to attain a global brand model hinged on applying laws of leverage, co-operative, alliance, and synergy like the restless ants that ride on economies of scale.

Kowontan O.

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Q & A

Seahorse Bioscience Launches First Product from the Partnership with Baystate Medical Center and UMass Amherst

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BILLERICA, Mass., April 1, 2013 /PRNewswire/ --Seahorse Bioscience, the world leader in instruments and assay kits for measuring cell metabolism recently launched the XF Plasma Membrane Permeabilizer (PMP), a reagent that enables scientists to measure the biochemistry and mechanisms of mitochondrial dysfunction, without the need for mitochondrial isolation or detergent-based permeabilization methods.

XF PMP was developed in partnership with the Pioneer Valley Life Sciences Institute (PVLSI), a joint venture of Baystate Medical Center and the University of Massachusetts Amherst, with the dual missions of biomedical research and economic development. The technology was exclusively licensed to Seahorse Bioscience by UMass Amherst and Baystate Health, the parent organization of Baystate Medical Center.

XF PMP can be used with the Seahorse XFe Extracellular Flux Analyzer, an instrument for measuring cell metabolism, in real-time, in a microplate. The reagent was developed for XF technology in part by Dr. Nagendra Yadava, the John Adams Investigator at PVLSI; and Dr. Alejandro Heuck, Ph.D., an Assistant Professor of Biochemistry and Molecular Biology at UMass Amherst.

"In the development of this potent new tool in biomedical analysis, we see the tremendous potential of collaborations between clinical and academic researchers and ingenuitive companies like Seahorse," said Richard Friedberg, M.D., Ph.D., chair of Pathology and chair of the Intellectual Property Committee at Baystate Health, who represented Baystate in working with Seahorse and UMass to establish the licensing agreement.

XF PMP creates pores in the cell plasma membrane, and delivers a degree of precision and ease-of-use that has not been available to scientists researching cell metabolism. A key element of XF PMP is the ability to assess mitochondrial function in adherent monolayers of permeabilized cells without damaging the mitochondrial membrane. By doing so, XF PMP enables metabolic substrates, compounds, and small proteins that otherwise would not cross the plasma membrane to reach the mitochondria.

"Seahorse's new XF Plasma Membrane Permeabilizer [PMP] enabled us to demonstrate that clinically-relevant concentrations of thiazolidinediones, a class of insulin sensitizers that includes Actos, specifically inhibited the mitochondrial pyruvate carrier, a protein at the hub of cellular metabolism. The simplicity and reliability of XF PMP made it easy to interrogate the mitochondrial function of small clinical samples and genetically modified cells without mitochondrial isolation, experiments that are traditionally difficult or impossible. Our work is providing a new understanding of the mechanism of action of an important class of drugs, and opens a new avenue for the development of drugs to treat diseases including type 2 diabetes, neurodegenerative disease, and heart failure," stated Anne N. Murphy, Ph.D., Associate Professor of Pharmacology at University of California, San Diego.

About Seahorse Bioscience

Seahorse Bioscience provides industry-leading analytical instruments, cell-based assay kits, and consumable labware products for biological research and drug discovery. Scientists worldwide use these tools to advance their research in understanding the role of mitochondrial dysfunction in cancer, neuroscience, immunology, obesity, diabetes, ageing, cardiovascular function, and safety toxicity. Seahorse is headquartered in Billerica, Massachusetts; has its manufacturing facilities in Chicopee, Massachusetts; and regional headquarters in Copenhagen and Shanghai. For more information visit: http://www.seahorsebio.com.

About Baystate Medical Center

Baystate Medical Center is an academic, research and teaching hospital that serves as the western campus of Tufts University School of Medicine. It is the major referral care center and only Level 1 trauma center for western Massachusetts, and is home to one of New England's busiest emergency rooms. One of Thomson Reuters/Truven Health Analytics' top 50 U.S. hospitals for cardiovascular care and top 100 U.S. hospitals, Baystate Medical Center is also designated a Leapfrog Top Hospital for quality and safety, is a Magnet hospital for nursing excellence, and is a six-time winner of the Beacon Award for Critical Care Excellence. http://www.baystatehealth.org/bmc

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Seahorse Bioscience Launches First Product from the Partnership with Baystate Medical Center and UMass Amherst

Dr. Ghislaine Beilin to Present Hybrid Energy Technology at the Upcoming Anti – Aging Medicine Congress in Monte Carlo

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Dr. Beilin, Vice President of the Federation of Aesthetic Medicine and Anti-Aging (Fdration Syndicale des Mdecines Esthtiques et Anti-Age), will present her findings with Hybrid Energy Technology, an emerging advancement in fractional radio frequency technology that works with the bodys natural mechanisms to deliver natural volume refilling, wrinkle reduction, skin rejuvenation and acne scars treatment without surgery, discomfort or downtime.

(PRWEB) April 02, 2013

Hybrid Energy Technology, was specifically developed to work with the bodys natural mechanism to promote wrinkle reduction, skin volumizing and acne scars improvement without the need for surgery. Treatment is virtually painless and suitable for all skin types and colors. Hybrid Energy treatments deliver significant dermal enhancement and skin renewal while minimizing the epidermal visible response so procedure can be performed in a convenient walk in-walk out session.

In a recent clinical evaluation Hybrid Energy demonstrated significant skin refilling, reduction of wrinkles as well as an improvement of skin texture, minimization of pores and volume increase.

The key advantage of Hybrid Energy (HE) Technology is the combination of Hot and Electrical Invisible Micro Ablation (IMA) which is administered via a disposable tip comprised of an array of micro pins.

Hot IMA facilitates smooth and painless penetration of the micro pins to target the mid dermis. Electrical IMA then selectively affects the target area using safe non-thermal energy. This creates direct dermis stimulation and triggers the bodys natural response mechanism in a safe process, with none to minimal pain and virtually no down time. As a result, while epidermal visible response is minimized, a significant effect is generated in the Dermis that delivers Auto-production of Hyaluronic Acid, Collagen Regeneration and Elastin Growth.

Dr. Beilin:

The new novel Hybrid Energy (HE) Technology delivers hot and electrical energies to create controlled micro ablation points penetrating up to the mid dermis. HE treatments promote a natural fractional healing process for dermal volume refilling and skin renewal. In my findings HE treatments demonstrated skin refilling effect along with improvement of skin texture and irregularities. No significant adverse effects were detected and treatments were well tolerated by patients with none to minimal pain and no down time.

Hybrid Energy Technology is available through Surgen- a cutting-edge platform which also integrates TriFractional Technology - an advanced anti-aging 3 pulse radio frequency procedure that enables effective fractional skin resurfacing and is suitable for enhancing the Hybrid Energy treatment. The Surgen platform has a user friendly touch screen with pre-programmed but adjustable parameters for each treatment type.

Mr. Amichai Bar-Nir CEO of Pollogen: We are very excited that the distinguished Dr. Beilin will be presenting Hybrid Energy at the Anti-Aging Conference in Monte Carlo. Pollogen is continuously listening to the demands of the market to deliver solutions for superior aesthetic results. The innovative Hybrid Energy Technology with Hot and Electrical Invisible Micro Ablation, provides a breakthrough answer for volume refilling, wrinkle reduction and skin rejuvenation all with a simple, virtually painless walk in walk out procedure. We are confident that it will quickly become an industry gold standard.

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Dr. Ghislaine Beilin to Present Hybrid Energy Technology at the Upcoming Anti - Aging Medicine Congress in Monte Carlo

Tribute to National Nutrition Month

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The American Academy of Nutrition and Dietetics designated March as National Nutrition Month. The 2013 theme, Eat Right, Your Way, Every Day, reminds us that we all are to daily focus on fueling our bodies with healthy nutritious food daily, regardless of culture and social influences.

For a practical example, the holidays of Easter and Passover are upon us. Both celebrations are traditional and have their staple food items we are all enjoy eating with family and friends. However, for some, coming around the meal table produces an anxiety to eating, especially in front of others. One reason may be because of the fear of eating too much of such a tasty meal. Another reason is the fear that one serving of this particular food item will cause them to cheat and destroy on their diet.

The solution to this dilemma rises from the scientific realization that there is no such thing as a bad food. The clue is simply the fact that the person has the authority to choose how much of a food item he would eat at a meal. Obviously if a person chooses to eat caramel cake, for example, he should need to make sure that he is reaching all of the other food groups that day and not over eating the cake to the demise of other food with higher nutritional value. He should eat the caramel in the proper portion. These food items would be found in the grains, vegetables, fruit, dairy, and meat groups.

In the same merit, there is also no such thing as a good food or a good food group as many in the media are proclaiming. Eating one eats all of his nutrients from a particular food group, for example the fruit group, he will actually become malnourished. If someone says, Coconuts are the best food on the planet to eat, for example, one would still need to focus on eating all of the other food groups and eat the coconut in moderate portion (1/2 cup). The same goes for food labeled as fat-free, sugar-free, dairy-free, taste-free ? This does not give us the green light to eat that food all day long worry-free. This too my friend is not healthy eating.

TIPS to Eat Right, Your Way, Every Day:

1) Remember there is no such thing as a good food or bad food Just eat your food in moderation. Visit http://www.eatright.org for ideas.

2) Decide if the food you are eating is being eaten because of the situation or because of an emotion

3) Remember you have choice! When you make your food choice, choose to eat it in the proper portion based on the nutrition information on the nutrition facts label or using tools like myfitnesspal.com.

4) Aim to eat food from the grains, dairy, fruit, vegetables, and meat/meatsubstitutes food groups every day.

So, whether your grandmother makes your favorite potato latkes or your favorite hometown sweet potato salad, choose to eat the food in the proper portion (about 15 grams of carbohydrate or a half-cup scoop) without guilt and anxiety that you will gain 5 pounds from one meal.

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Tribute to National Nutrition Month

Travel with Val: Okinawan elders share their secrets for healthy longevity

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Residents of Japan's Okinawa Islands are famously known for their longevity, and the locals give a few tips on the right foods to eat. YNN's Valarie D'Elia filed the following report.

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OKINAWA ISLANDS -- Japans Okinawan island group has a global reputation for longevity, with a healthy number of elderly becoming centenarians.

Rice farmer Hitoshi Nane, 78, can expect many more good years because his parents both lived to be 99. But Nane isn't counting on genes alone, so he doesn't stuff himself.

"People don't eat until they are full, but 80 percent full," Nane said through an interpreter.

He also enjoys a stiff drink of awamori, the rice-based local alcoholic beverage.

Nane lives on Iriomote, the largest island in Okinawa's Yaeyama Islands, where in the village, a group of octogenarians gather regularly for a game of "gate ball."

With the help of an interpreter, they share their tips for a long life.

"Smiling, talking to people, it's very good for health," said one elder.

"Take a nap. Also, I live by myself, so it's not stressful," said another.

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Travel with Val: Okinawan elders share their secrets for healthy longevity

Longevity Global Inc. Now Offers the Most Prolific Welders and Welding Equipment

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Longevity Global Inc. stores all top quality welding equipment and welders for cutting and welding. These can also be used for a wide variety of welding tasks with ease and with fine precision.

Hayward, ca (PRWEB) March 30, 2013

One spokesperson at Longevity Global Inc. stated, Through innovation, experience, and engineering, we provide customers with affordable and reliable welding machines in all ranges of production from the garage users, to pipe welders, and ship builders. We are one of the biggest sellers of the equipment we offer, and we import and sell more units than any other company in America.

Welders and welding machines that Longevity Global Inc. brings into the market always outperform the leading brands in terms of quality, pricing and customer services. It believes there is always an area of improvement to excel and outperform the competitors and hence, constantly improves welding equipment in terms of technology, customer services or anything else.

It offers an unmatched five year parts and labor warranty on welders. Longevity also has a hassle-free warranty system in place i.e. if customers face any sort of issue regarding the bought welding equipment; they can get the same replaced. Notwithstanding, the organization offers a full line of welding equipment for both Do-It-Yourself (DIY) and professional welding purposes.

About the Company

Since they started in 2001 Longevity Global Inc. is recognized worldwide for providing reliable wielding, cutting, and power generating equipment. Most of their equipment comes with an unmatched warranty of 5-Years on both parts and labor. They provide customer with affordable and reliable welding machines in all ranges of production from the garage users, to pipe welders, and ship builders. It has wide network of global distributors to bring better welding equipment and devices.

For further information on their offerings visit http://www.longevity-inc.com

Contact Address

Longevity Global Inc.

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Longevity Global Inc. Now Offers the Most Prolific Welders and Welding Equipment

5K Run for Your Life

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The Student Health Advocacy Committee's 7th annual 5K Run for Your Life at the University of Arizona is quickly approaching. On Saturday April 6th, in addition to running for a great cause, there will be free t-shirts and food, music and tons of cool prizes!

Here are some of the details:
To Register: http://rfyl.arizona.edu

What: A 5K fun run and walk- there will be food, drinks, a DJ, raffles, and prizes! FREE t-shirts for anyone participating!

Where: University of Arizona Mall near the Student Union

When: Saturday, April 6th 2013

Registration/Check-In begins at 7:30 am
Get ready to run for your life at 9:00 am!

Cost: $10 early group registration (5+ people per group until March 29th)
$15 group registration (5+ people per group after March 29th and the day of the event)
$15 early registration (until March 29th)
$20 regular registration (after March 29th and the day of the event)

The Cause: All funds raised will benefit the Tucson Hopefest- check out their website for more info: http://www.hopefest.org

Questions?
Email:
UARun4YourLife13@gmail.com

Source:
http://physiologynews.blogspot.com/2013/03/5k-run-for-your-life.html

Italy pushes on with controversial stem cell therapy

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Italian health officials are allowing a handful of patients to continue with a controversial stem cell therapy amid protests from scientists that the treatments are unproven and unsafe.

The Stamina Foundation has been administering the therapy at the public hospital Spedali Civili of Brescia to people with a range of degenerative diseases. Their approach is based on mesenchymal stem cells, derived from bone marrow, which can become mature bone and connective tissue.

In 2011 the hospital agreed to host the research and assist with cell extraction and patient treatments, stirring protests from the medical community. "The hospital is not even listed among the 13 Italian authorised stem cell factories," says Michele de Luca, director and gene therapy programme coordinator at the Centre for Regenerative Medicine in Modena. After an inspection in 2012, Italian drug regulator AIFA ordered an immediate halt to Stamina's stem cell treatments at the hospital.

The AIFA report says the Stamina Foundation's treatment did not follow Italy's official path required for clinical approval. So far no scientific publications describing its effectiveness are available.

But the halt sparked protests among patients' families who believed the treatment was working. Some appealed to the courts, and as a result a few patients were allowed to go ahead with the therapy. On 15 March, a group of 13 Italian stem cell researchers published an open letter to the country's Minister of Health, Renato Balduzzi, asking him to shut down all of the Stamina Foundation's treatments at the hospital.

Instead Balduzzi signed a bill last week authorising the foundation to continue treatments in patients who had already begun the regime unless they are experiencing serious side effects.

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Italy pushes on with controversial stem cell therapy

Stem Cell Therapy Market in Asia-Pacific to 2018 Market Research Report Available at MarketResearchReports.biz

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MarketResearchReports.biz Publishes Stem Cell Therapy Market in Asia-Pacific to 2018 Commercialization Supported by Favorable Government Policies, Strong Pipeline and Increased Licensing Activity. Buy the copy of this Report @ http://www.marketresearchreports.biz/analysis-details/stem-cell-therapy-market-in-asia-pacific-to-2018-commercialization-supported-by-favorable-government-policies-strong-pipeline-and-increased-licensing-activity

Albany, NY (PRWEB) March 29, 2013

To Read the Complete Report with TOC Visit: http://www.marketresearchreports.biz/analysis/155690

This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GBI Researchs team of industry experts.

GBI Research analysis finds the stem cell therapy market was valued at $545m in 2012, and is projected to grow at a Compound Annual Growth Rate (CAGR) of 10% from 2012 to 2018, to attain a value of $972m in 2018. The market is poised for significant growth in the forecast period due to the anticipated launch of JCR Pharmaceuticals JR-031 (2014) in Japan and FCB Pharmicells Cerecellgram (CCG) (2015) in South Korea.

Related Report: Mobile Health (mHealth) - Enhancing Healthcare and Improving Clinical Outcomes

The research is mainly in early stages, with the majority of the molecules being in early stages of development (Phase I/II and Phase II). Phase I/II and Phase II contribute 67% of the pipeline. Stem cell research is dominated by hospitals/universities/institutions, which contribute 63% of the molecules in the pipeline. The dominance of institutional research is attributable to uncertain therapeutic outcomes in stem cell research.The major companies conducting research in India include Reliance Life Sciences and Stempeutics Research Pvt Ltd, among others. The major institutions include PGIMER and AIIMS.

Latest Report: Global SMB Web Analytics Market 2012-2016

Scope

Country analysis of regulatory framework of India, China, South-Korea, Japan and Singapore

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Stem Cell Therapy Market in Asia-Pacific to 2018 Market Research Report Available at MarketResearchReports.biz

ETX nutrition carnival today–Education, fresh fruit, and more!

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Released by: NET HEALTH

Tyler (TX) National Nutrition Month is a nutrition education and information campaign created annually in March by the American Dietetic Association. The campaign focuses attention on the importance of making informed food choices and developing sound eating and physical activity habits. This year the Northeast Texas Public Health District (NET Health) will focus on healthier food choices you can make to incorporate into your daily lifestyle.

National Nutrition Month also promotes the American Dietetic Association and its members to the public and the media as the most valuable and credible source of timely, scientifically based food and nutrition information. The theme for March 2013 is "Eat Right, Your Way, and Every Day."

"Making a positive change in your eating habits can impact your entire family. Poor nutrition and sedentary lifestyles are the most important factors in contributing to the rise of obesity in the adults and children of East Texas", says George Roberts, CEO of NET Health.

The food and physical activity choices made everyday affect your health and how you feel today and in the future. Eating a nutritious diet and engaging in regular physical activity may reduce chronic diseases, such as heart disease, type 2 diabetes and certain cancers. Furthermore, poor diet and physical inactivity are the most important factors contributing to the rise in obesity in this country.

George T. Roberts, Jr. Chief Executive Officer

You can participate in the Nutrition Carnival Friday at the NET Health WIC Clinic, 815 N Broadway, Tyler, from 9:30 a.m. until noon.

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ETX nutrition carnival today--Education, fresh fruit, and more!

Head-on collisions between DNA-code reading machineries accelerate gene evolution

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Public release date: 28-Mar-2013 [ | E-mail | Share ]

Contact: Leila Gray leilag@uw.edu 206-685-0381 University of Washington

Bacteria appear to speed up their evolution by positioning specific genes along the route of expected traffic jams in DNA encoding. Certain genes are in prime collision paths for the moving molecular machineries that read the DNA code, as University of Washington scientists explain in this week's edition of Nature.

The spatial-organization tactics their model organism, Bacillus subtilis, takes to evolve and adapt might be imitated in other related Gram-positive bacteria, including harmful, ever-changing germs like staph, strep, and listeria, to strengthen their virulence or cause persistent infections. The researchers think that these mechanisms for accelerating evolution may be found in other living creatures as well.

Replication the duplicating of the genetic code to create a new set of genes and transcription the copying of DNA code to produce a protein are not separated by time or space in bacteria. Therefore, clashes between these machineries are inevitable. Replication traveling rapidly along a DNA strand can be stalled by a head-on encounter or same-direction brush with slower-moving transcription.

The senior authors of the study, Houra Merrikh, UW assistant professor of microbiology, and Evgeni Sokurenko, UW professor of microbiology, and their research teams are collaborating to understand the evolutionary consequences of these conflicts. The major focus of Merrikh and her research team is on understanding mechanistic and physiological aspects of conflicts in living cells including why and how these collisions lead to mutations.

Impediments to replication, they noted, can cause instability within the genome, such as chromosome deletions or rearrangements, or incomplete separation of genetic material during cell division. When dangerous collisions take place, bacteria sometimes employ methods to repair, and then restart, the paused DNA replication, Merrikh discovered in her earlier work at the Massachusetts Institute of Technology.

To avoid unwanted encounters, bacteria orient most of their genes along what is called the leading strand of DNA, rather than the lagging. The terms refer to the direction the encoding activities travel on different forks of the unwinding DNA. Head-on collisions between replication and transcription happen on the lagging strand.

Despite the heightened risk of gene-altering clashes, the study bacteria B. subtilis still orients 25 percent of all its genes, and 6 percent of its essential genes, on the lagging strand.

The scientist observed that genes under the greatest natural selection pressure for amino-acid mutations, a sign of their adaptive significance, were on the lagging strand. Amino acids are the building blocks for proteins. Based on their analysis of mutations on the leading and the lagging strands, the researchers found that the rate of accumulation of mutations was faster in the genes oriented to be subject to head-on replication-transcription conflicts, in contrast to co-directional conflicts.

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Head-on collisions between DNA-code reading machineries accelerate gene evolution

Hospitals performing stem cell therapy are yet to be accredited – DOH

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By: Azer N. Parrocha, Philippine News Agency March 28, 2013 3:16 AM

InterAksyon.com The online news portal of TV5

MANILA, Philippines - Although guidelines for stem cell therapy in the country have already been released, the Department of Health (DOH) on Wednesday reminded the public that hospitals performing the treatment are as of the moment, not accredited.

Health Secretary Enrique Ona, in a press conference, explained that for a hospital or clinic to be considered accredited, a years worth of tests and studies have to be done to prove that the procedure is indeed safe and effective.

I hope the general public understands that these stem cells, although called innovative (form of treatment) is not standard and should not be advertised as though it is already an accepted form of treatment, Ona said.

Ona explained that the DOH still continues to look on the capacity of the treatment and will make sure that the stem cells used for procedure are accepted as protocol.

Stem cells like those coming from embryos or animals which are restricted will also be looked into by the DOH to see if there are any hospitals or clinics that do not abide by the administrative order.

If the protocol is accepted, report of results should be evaluated, he said. They are evaluated about a year to see if their claim is effective [and if it is] it will be validated.

At present, there are no hospitals or clinics completely accredited for the stem cell therapy yet. Given that, certain processes must be followed before doctors are allowed to use the treatment.

I cannot see a so-called clinic yet certifying that there is a process that is very effective, Ona explained. We have to see the type of stem cell, the type of claim they have.

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Hospitals performing stem cell therapy are yet to be accredited – DOH