Intermountain preps precision medicine tool for commercialization – Healthcare IT News

Intermountain Healthcare on Monday announced that its stepping closer to bringing a version of its precision medicine tool for cancer to the open market.

The health system, in fact, is pumping an additional $15 million into its spin-out Navican Genomics, which makes the TheraMap technology for matching patients with prioritized treatment options or appropriate clinical trials.

[Also:Promise of precision medicine depends on overcoming big obstacles] While precision medicine has great potential to positively impact cancer patients, its use is currently fragmented at best, Navican CEO Ingo Chakravarty said in a statement. TheraMap will provide precision care for all cancer patients, not just a few.

Navican employs sequencing tests developed at Intermountain to determine exactly which gene mutations are causing the cancer. From there, TheraMap provides testing and treatment options for the greatest number of actionable gene mutations, the startup said.

Intermountains Innovations division launched Navican Genomics in October 2016.

Twitter: @Bernie_HITN Email the writer: bernie.monegain@himssmedia.com

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Two gene editing firms unveil cancer drug pacts as ASCO comes to a close – Boston Business Journal

Two gene editing firms unveil cancer drug pacts as ASCO comes to a close
Boston Business Journal
The research drew blowback from Intellia, which said that the claim about off-target effects lacked evidence and was based on a sample. In addition to Intellia and CRISPR Therapeutics, the other leading gene-editing firm is Cambridge-based Editas ...

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Two gene editing firms unveil cancer drug pacts as ASCO comes to a close - Boston Business Journal

Solving Africa’s food insecurity through biotechnology – NIGERIAN TRIBUNE (press release) (blog)

There is an increasing focus on science being linked to providing practical solutions to agricultural problems. There is also increasing awareness of technology, although the channels used for information and creating change in the way information is passed and understood by the receiver are poorly developed.

Biotechnology is no longer a new technology in Africa; some countries in Africa have adopted the technology, while some other countries are currently conducting confined field trial for the technology.

In Nigeria, Genetically Modified Organisms (GMOs) which is a component of biotechnology is currently undergoing confined field trial in various locations. It is expected that in the next three years, the commercialisation of the BT cotton will commence in the country.

Africa as a continent in the recent past have suffered a high level of food insecurity following the actions and inaction of various governments to put sustainable policies to fast track agricultural development.

Some countries in Africa have also experienced food shortage due to some natural disaster which includes flood, pest attack, insect infestation and drought.

In some countries, the uses of manual and outdated method of farming have contributed immensely to the countrys dependence for food supply on some developed countries that have used technology to advance their agricultural sector.

Biotechnology have been adopted by various countries to develop their agricultural sector which have made them self sufficient in food production and earned them foreign exchange through exportation of agricultural products.

Many African countries have been skeptical of adopting biotechnology following some baseless and unscientific criticism from some quarters on the new technology.

This singular act of negligence and gullibility exhibited by these African countries have further subjected them to being importers of food products from countries that have developed there agricultural technology.

In Ghana, the commercialization of GMOs may not be possible until the court injunction issued against its further release in Ghana have been concluded.

However, good news emerged as the Plant Breeders Bill was said to be underway and soon to be signed into law in Ghana to protect the developers of the technology and encourage the investment in science and technology beyond the countrys budget.

Instead of the critics of the technology to say science is not good at all, they should discuss on its deployment which can be useful to our economy.

The Open Forum On Agricultural Biotechnology (OFAB), Ghana have visited all the regions in Ghana and information materials on biotechnology have been translated into local languages.

It is worthy to note that the Ghanaian government does not fund science, to this end, funding is needed to scale up educational activities on modern biosafety issues in Ghana.

In Nigeria, it is sad to note that the country has one of the lowest usage rates of agriculture inputs and ranks the lowest on agriculture indices of mechanization and irrigation.

Insect and pest problems, climate change issues and increasing population were also attributed as the reasons for poor productivity.

Meanwhile, there are some Genetically Modified crops that can withstand insects and pests attack, while some are drought resistant. These crops if adopted could be used by farmers to upscale the countrys food production without the crops been damaged by pests and insects.

However, Maize, cotton, rice, cassava, Sorghum (ABS) have been said to be the first GM crops to be introduced in Nigeria for commercialisation soon.

It is also worthy of note that the Biosafety law was signed in Nigeria in 2015 which gave rise to the establishment of regulatory agency, National Biosafety Management Agency (NBMA) same year.

Since its establishment, NBMA has carried out 3 approvals and accredited research institutes and universities for GM research.

OFAB Nigeria in its advocacy drive has carried out advocacy visits, capacity building, Seeing is Believing Tours, workshops and seminars, radio and tv programs, social media campaigns to enlighten the public and policy holders with the right information on the safety of biotechnology and its practices.

In Burkina Faso, Cotton is one of the major driver of the countrys economy, 85 per cent of population of Burkina Faso is active in agriculture and cotton is its number one cash crop contributing 25 per cent of agricultural income.

There is evidence that cotton is locomotive for cereal crops such as maize and sorghum in Burkina Faso.

In Burkina Faso, necessary steps have been taken towards the release of GM cotton- Pre-release trials, BT cotton seed multiplication, Commercial production of GM Bollgard II Cotton and cultivation field, commercial production since 2009.

BT cotton (GM Cotton) have pushed Burkina Faso in the cotton production ranking from 11th in 1990s to 1st position in Africa since 2010.

Genetically Modified Organisms is a technology which African countries cannot afford to neglect, this new technology will help African countries to upscale its food production, guarantee food security and earn foreign exchange for the countries.

The era of dependence on food importation should be over in Africa. The governments in Africa should look for possible ways of adopting biotechnology in food production, this will go along way to addressing food insecurity and guarantee self-sufficiency in food production.

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What Should Investors Make Of The Trading Chart Of Puma Biotechnology, Inc. (PBYI)? – NY Stock News


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Puma Biotechnology, Inc. (PBYI) is now trading with a very clear set of technicals. Taken together they paint a very compelling picture of how investors and traders should be approaching PBYI. Technical charts are very important tools for traders, but ...
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Mitosis: Anatomy of a Custom Keyboard – Hackaday

Ergonomic. Wireless. Low-latency. Minimalist. Efficient. How far do you go when you design your own open-source keyboard? Checking off these boxes and providing the means for others to do so, Redditor [reverse_bias] presents the Mitosis keyboard, and this thing is cool.

The custom, split as the namesake implies mechanical keyboard has 23 keys on each 10 cm x 10 cm half, and, naturally, a custom keymapping for optimal personal use.

Upper and lower PCBs host the keys and electronic circuits respectively, contributing to the sleek finished look. Key caps and mechanical switches were ripped from sacrificial boards: two Waveshare core51822 Bluetooth modules are used for communication, with a third module paired with a Pro Micro make up the receiver.[reverse_bias] spent a fair bit of time attempting to minimize the power consumption of the keyboard so it could be powered by a pair of coin batteries, giving it an estimated six month lifespan of daily use. These are pinched between the upper and lower boards by little dabs of solder and the slight spring tension of the boards themselves. However, a bit of de-soldering is required to change the battery.

Laser-cut adhesive neoprene adorns the base, proving a comfortable springiness, grip, and protection for the pins as well as cushioning from any debris on the desk. The final product has almost zero flex, has a low enough profile to negate the need for a wrist rest. If youre interested in building your own, [reverse_bias] has linked all the relevant files here.

Of course, one could always go the opposite way and opt for a more heavyweight option.

[Thanks for the tip, Tyberius Prime!]

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These Are Actual Biology Courses Offered At Evergreen State College – The Daily Caller

Evergreen State College, the site of viral student protests over the past two weeks, offers multiple courses in its biology department that veer dramatically from the hard sciences,with themes like feminism, race and power.

While the school offersmore traditional biology courses like General Biology and Anatomy and Physiology, it also hasclasses that provide more details about feminism and social movements than with the study of human or plant life.

Evergreen State Colleges Biology Department will offer a course during the 2017 fall semester and 2018 spring semester entitled,Reproduction: Gender, Race, and Power. The course will provide students with an overview of human reproduction, but will pay attention to gender and race as vectors of power that affect how reproduction is discussed, legislated, and experienced in the United States.

The course description claims that biology is shaped and defined by cultural norms. One of the primary goals of the course is to collectively dismantle the idea that women are defined as such by an innate reproductive capacity. To achieve this end, students will be required to read texts that address the experiences of trans and gender-nonconforming individuals, and discuss the ways in which contraception, abortion, forced sterilization, genetic testing, and other forms of reproductive control both reflect, and have been used to perpetuate, systemic racism.

After completing the course, students will have an understanding of how power and privilege operate on a variety of bodies, including our own.

Another course the college offered its junior and senior students in 2016 wasentitled Feminist Epistemologies: Critical Approaches to Biology and Psychology. Professors allegedly built thecourse to help students discover how knowledge is generated from a feminist theoretical perspective.

To achieve its stated goal, students read feminist philosophy of science, sociological studies on science and how it operates in society, research on women scientists, and critical deconstructions of sociobiology and the related field of evolutionary psychology.

Evergreen State College made headlines after one of the schools biology professors, Bret Weinstein, spoke out against the schools annual Day of Absence. A group of students and faculty at Evergreen organize one day every year where they meet off campus, as a symbolic remembrance of a famous play whereall the black residents of a Southern town fail to show up one morning.

The group decided to mix things up in 2017, and asked that all white students, staff and faculty will be invited to leave campus for the days activities. After Weinstein called the actions a show of force, and an act of oppression, students responded in anger.

Viral protests forced the school to cancel classes for three straight days.(RELATED: Evergreen Cancels Classes For Third Day In A Row)

Some 50 students showed up outside Weinsteins classroom to call him a racist and a supporter of white supremacy to his face.

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Chapman University's Physical Therapy Program receives 10-year Accreditation – Chapman University: Happenings (blog)

June 5, 2017

Chapman Universitys Department of Physical Therapy (DPT) program has received a 10 year reaccreditation by its accrediting body, the Commission on Accreditation in Physical Therapy Education (CAPTE).

A 10 year accreditation reflects the programs deep commitment to physical therapy education and the resulting reputation DPT has in the region for graduating extraordinary clinicians, said Janeen Hill, Ph.D., dean of Chapmans Crean College of health and Behavioral Sciences. This accreditation reflects sustained effort by DPT to produce a strong self-study and to demonstrate excellence to the site visiting team from CAPTE. Many congratulations to the DPT faculty and staff for this achievement.

The notification letter included the following commendation:

The Commission commends the program for the quality of its Self-study Report. The program submitted a well-written, thorough, concise and comprehensive Self-study Report that clearly conveyed the nature and scope of the educational experience.

Chapmans physical therapy program enjoys the title of the oldest continually accredited program in California. Since 1928, Chapmans Department of Physical Therapy is one of the longest running physical therapy programs in the United States. All of the faculty are licensed practitioners with advanced degrees, and the student-to-faculty ratio is 12:1, providing a highly personalized education. In 2017, the program received 1,450 applicants for a coveted 80 openings. Chapmans first-time licensure pass rate for PT graduates in 2016 was 100 percent, in addition to our overall pass rate for the past five years also being 100 percent, making the PT program one that aggressively prepares our graduates for success in the work force.

The graduate program offers two degrees: the Doctor of Physical Therapy degree for students interested in becoming a physical therapy professional; and the Transitional Doctor of Physical Therapy degree for physical therapists with baccalaureate or master degrees seeking to further their education to achieve the Doctor of Physical Therapy degree.

Chapmans brand new, state-of-the-art health science campus offers students access to top-of-the-line labs and physical therapy equipment, including a traditional motion analysis lab, an anti-gravity treadmill, and a state-of-the-art 180 degree Virtual Reality (VR) Gait Real-time Analysis Interactive Lab (GRAIL) by Motekforce. The VR motion analysis laboratory comes with a dual-belted instrumented treadmill with a self paced option and 6-degrees of freedom, integrated 10 camera and EMG systems. The GRAIL provides the DPT program faculty instrumentation to conduct cutting edge human movement system intervention studies.

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Chapman University's Physical Therapy Program receives 10-year Accreditation - Chapman University: Happenings (blog)

Cops speak less respectfully to black community members – Stanford University News

The first systematic analysis of police body camera footage shows that officers consistently use less respectful language with black community members than with white community members, according to new Stanford research.

Stanford researchers have developed a computational tool to analyze language extracted from police body camera footage as data for understanding law enforcement interaction with the community. (Image credit: Ryan Johnson/Flickr/Creative Commons)

Although they are subtle, these widespread racial disparities in officers language use may erode police-community relations, said the researchers who conducted the study, published June 5 in Proceedings of the National Academy of Sciences.

Our findings highlight that, on the whole, police interactions with black community members are more fraught than their interactions with white community members, explained Jennifer Eberhardt, co-author of the study and professor of psychology at Stanford.

The racial disparities in respectful speech remained even after the researchers controlled for the race of the officer, the severity of the infraction, and the location and outcome of the stop.

To analyze the body camera footage, a multidisciplinary team from Stanfords psychology, linguistics and computer science departments first developed a new artificial intelligence technique for measuring levels of respect in officers language. They then applied this technique to the transcripts from 981 traffic stops the Oakland Police Department (OPD) made in a single month.

The researchers novel technique demonstrated that white residents were 57 percent more likely than black residents to hear a police officer say the most respectful utterances, such as apologies and expressions of gratitude like thank you. Meanwhile, black community members were 61 percent more likely than white residents to hear an officer say the least respectful utterances, such as informal titles like dude and bro and commands like hands on the wheel.

To be clear: There was no swearing, said Dan Jurafsky, a study co-author and Stanford professor of linguistics and of computer science. These were well-behaved officers. But the many small differences in how they spoke with community members added up to pervasive racial disparities.

The fact that we now have the technology and methods to show these patterns is a huge advance for behavioral science, computer science and the policing industry, said Rob Voigt, a Stanford linguistics doctoral student and lead author of the study. Police departments can use these tools not only to diagnose problems in police-community relations but also to develop solutions.

The study is not the first time Eberhardt has collaborated with the OPD to study possible racial disparities in policing. In 2014, the City of Oakland contracted with Eberhardt and her team to assist the Oakland Police Department in complying with a federal order to collect and analyze data from traffic and pedestrian stops by race.

OPD, like many police departments nationwide, has been using body-worn cameras to monitor police-community interactions. But drawing accurate conclusions from hundreds of hours of footage is challenging, Eberhardt said. Just cherry-picking negative or positive episodes, for example, can lead to inaccurate impressions of police-community relations overall, she said.

The police are already wary of footage being used against them, Eberhardt said. At the same time, many departments want their actions to be transparent to the public.

To satisfy demands for both privacy and transparency, the researchers needed a way to approach the footage as data showing general patterns, rather than as evidence revealing wrongdoing in any single stop.

Yet researchers cant just sit and watch every single stop, Eberhardt explained. It would take too long. Besides, their own biases could affect their judgments of the interactions.

Together, Eberhardt, Jurafsky and seven other colleagues examined transcripts from 183 hours of body camera footage from 981 stops, which 245 different OPD officers conducted in April 2014.

In the first phase of the study, human participants examined a subsample of the transcribed conversations between officers and community members without knowing the race or gender of either and rated how respectful, polite, friendly, formal and impartial the officers language was.

In the second phase, the researchers used these ratings to develop a computational linguistic model of how speakers show respect, including apologizing, softening commands and expressing concern for listeners well-being. They then created software that automatically identified these words, phrases and linguistic patterns in the transcripts of the officers language.

In the third phase, the researchers used this software to analyze the remaining transcripts a total of 36,000 officer utterances with 483,966 words. Because the team had so much data, they could statistically account for the race of the officer, the severity of the offense and other factors that could affect officers language.

Understanding and improving the interactions between the police and the communities they serve is incredibly important, but the interactions can be difficult to study, Jurafsky said. Computational linguistics offers a way to aggregate across many speakers and many interactions to detect the way that everyday language can reflect our attitudes, thoughts and emotions which are sometimes outside of our own awareness.

Our findings are not proof of bias or wrongdoing on the part of individual officers, Eberhardt cautioned. Many factors could drive racial disparities in respectful speech.

The research team is currently extending their work to analyze the language used by community members during the traffic stops and to study other linguistic features captured by the body cameras, including tone of voice. They also plan to explore the interplay of officers and community members speech as it unfolds over time.

There is so much you can do with this footage, Eberhardt said. We are very excited about the possibilities.

Eberhardt praised the City of Oakland and OPD for being open to having their data examined, and said she hopes that other departments across the country will invite similar collaborations.

Im hopeful that, with the development of computational tools like ours, more law enforcement agencies will approach their body camera footage as data for understanding, rather than as evidence for blaming or exonerating, Eberhardt said. Together, researchers and police departments can use these tools to improve police-community relations.

The studys other co-authors were Nicholas Camp, Rebecca Hetey and Camilla Griffiths of the Department of Psychology; and Vinodkumar Prabhakaran, William Hamilton and David Jurgens of the Department of Computer Science.

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What millennials really want in the workplace – CBS News

Different surveys have widely varying opinions on the millennial generation -- those between the ages of 18 and 30 who are entering or already in the workforce. Some imply this is a group of slackers living in their parents' basements. Others show them as ambitious, hardworking and struggling to pay off college debt with several part-time jobs.

How do they see themselves? A new report from the blog Squared Awayshows a lot of "youthful optimism" among this generation. But is it justified? "The changing job market is making it increasingly difficult for young adults to get their careers off to the right start," said Kim Blanton, writer and editor for Squared Away at the Center for Retirement Research at Boston College.

That's because the employment landscape is changing. Millennials are often accused of changing jobs just to earn more money. But that may not be their choice, said Blanton, citing a recent Federal Reserve surveyshowing that young adults prefer jobs that are "permanent and steady," not ones like driving for Uber or freelancing, which aren't secure and could change from month to month even when they make more money.

Surprisingly and contrary to popular belief that millennials jump jobs for money, they actually "prefer steady employment to higher pay," according to the Fed survey.

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According to a survey conducted by the AAA Foundation for Traffic Safety, young people between the ages of 19 and 24 are more likely to admit the...

Sometimes higher pay isn't even an option. According to the U.S. Bureau of Labor Statistics (BLS),the fastest-growing jobs are often part-time, low-paying and seasonal, and lack health benefits, retirement savings accounts and paid-time off.

The BLS report found that the top 10 careers expected to generate 5 million jobs by 2024 include personal care and home health aides; food preparation, cooks and servers; nursing assistants; and retail sales, which net annual earnings below $30,000 -- or just over a living wage for a family of four in most areas.

Slightly above that level were customer service representatives and construction workers, with salaries between $30,000 and $40,000 per year. Registered nurses and operations managers were found to earn more than $60,000 annually.

According to the Fed, a college degree -- with its staggering debt averaging $37,000 in 2016 -- doesn't guarantee a career. Only 45 percent of millennials reported obtaining employment in their field.

So is it time to reorient job training in this new world of employment? "A bright spot is the so-called STEM jobs, in the science, technology, engineering and mathematics fields," said Blanton. "Two-thirds of young adults who studied in these areas are getting jobs in these fields, which experienced the highest earnings in the BLS's fastest growing occupations." In contrast, the success rate was less for graduates in the life sciences, business, health and behavioral science fields.

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But president cites industry study that doesn't count clean energy jobs or the cost of climate change

Another viable choice: Don't attend college. Young adults with noncollege certificates and technical degrees had an easier time getting jobs in their fields than those with associates' and only slightly more trouble than those with bachelors' degrees.

Perhaps millennials are more hopeful now because they were so-down-in the-mouth during the Great Recession and the years shortly afterwards. In 2013, less than half were optimistic about future employment opportunities, and only 64 percent said they were able to cover their monthly expenses.

By 2015 those numbers had risen to 61 percent who were hopeful and 73 percent who were able to crack the monthly nut. But, of course, that still left more than a quarter who were sheltering with their parents, or nearly broke.

What about 2017? The May jobs report showed a 16-year low unemployment rate of 4.3 percent but also a slow-growing economy, said Director Michael Hicks of the Center for Business and Economic Research at Ball State University. So perhaps it's time for yet another millennial survey.

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Essential Science: Methylene Blue as an anti-aging treatment – Digital Journal

The fountain of youth may be a matter for mythology; however, considerable scientific research goes into seeing whether the aging process can be slowed down. A discovery that had any kind of true anti-aging effect (as opposed to questionable anti-wrinkle creams) would represent a major step forwards in scientific understanding as well as being, if it could be commercialized, highly lucrative. The openings of an anti-aging treatment could exist with a chemical called methylene blue. As well as a stain for the microscopic examination of fungi, methylene blue is a common and relatively inexpensive antioxidant. The chemical has been used in the clinical treatment of many ailments, but not, until now anti-aging. The possible breakthrough comes from the University of Maryland and here researchers have been investigating the effect of methylene blue on human skin. Methylene blue Methylene blue (methylthioninium chloride) is both a medication and dye. As a medication it is used to treat methemoglobinemia (a blood disease leading to shortness of breath). In the past it was used for cyanide poisoning and urinary tract infections. When required medically, the drug is administered by injection into a vein. With people aging (sometimes spelled ageing) represents the accumulation of changes in a person over time. These changes include the physical, psychological, and social. Variations are seen with things like reaction time as well as physical changes, especially to the skin. Speaking with Science Alert, lead researcher Kan Cao explains about the research: Our work suggests that methylene blue could be a powerful antioxidant for use in skin care products. So far interesting, but there are plenty of skin care products on the market. However, Dr. Cao drops in the key difference: "The effects we are seeing are not temporary. Methylene blue appears to make fundamental, long-term changes to skin cells. To demonstrate this, the researchers exposed healthy and diseased skin cells, taken from middle-aged patients, to methylene blue together with three other established chemicals known to function as antioxidants. The experimental work showed that the methylene blue was superior to the other chemicals at improving the symptoms of aging in both the healthy and diseased skin cells. With the diseased cells, these were affected by progeria. Progeria is an extremely rare genetic disorder in which symptoms resembling aspects of aging are manifested at a very early age. Those born with progeria typically live to their mid-teens to early twenties. With both types of skin cell the researchers noted a reduction in cell death, as well as a decrease in deleterious relative oxygen species, and an increase in cell division in skin cells called fibroblasts. A fibroblast is a type of cell that synthesizes the extracellular matrix and collagen. For further study Dr. Cao exposed fibroblasts from donors over age 80 to methylene blue. The exposure was over a four week period. As with the earlier work, improvements were noted. Further analysis revealed a reduction in the expression of two genes that are commonly used to indicate aging in cells. These genes are termed senescence-associated beta-galactosidase and p16. While the process demonstrates considerable attention, further research is required and no tests have yet been undertaken on people. The following video explains more about the research: The research is published in the journal Scientific Reports, under the heading Anti-Aging Potentials of Methylene Blue for Human Skin Longevity. Essential Science This article is part of Digital Journal's regular Essential Science columns. Each week Tim Sandle explores a topical and important scientific issue. Last week we explored the use of bioelectricity as a powerful way of killing pathogenic bacteria. The week before we looked at how nanotechnology can be used to rapidly and non-invasively treat broken bones.

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New cancer medicine targets rare genetic flaw, finds study – Hindustan Times

An experimental cancer medicine called larotrectinib has shown promise in treating a diverse range of cancers in people young and old, researchers said at a major cancer conference in the United States.

The treatment targets a genetic abnormality which is often found in rare cancers including salivary gland cancer, juvenile breast cancer, and a soft tissue cancer known as infantile fibrosarcoma which are particularly difficult to treat. This abnormality also occurs in about 0.5% to 1% of many common cancers.

In the study released at the American Society of Clinical Oncology conference, 76% of cancer patients both children and adults with 17 different kinds of cancer responded well to the medicine.

A total of 79% were alive after one year. The study is ongoing. And 12% went into complete remission from their cancer.

The clinical trial included 55 patients 43 adults and 12 children. All had advanced cancers in various organs, including the colon, pancreas and lung, as well as melanoma.

These findings embody the original promise of precision oncology: treating a patient based on the type of mutation, regardless of where the cancer originated, said lead study author David Hyman, chief of early drug development at Memorial Sloan Kettering Cancer Center in New York.

We believe that the dramatic response of tumours with TRK fusions to larotrectinib supports widespread genetic testing in patients with advanced cancer to see if they have this abnormality.

Researchers said 76% of cancer patients both children and adults with 17 different kinds of cancer responded well to the medicine. (Shutterstock)

Made by Loxo Oncology Inc., larotrectinib is a selective inhibitor of tropomyosin receptor kinase (TRK) fusion proteins. TRK proteins are a product of a genetic abnormality when a TRK gene in a cancer cell fuses with one of many other genes, researchers said.

The US Food and Drug Administration has not yet approved the treatment for widespread use.

The treatment was well tolerated by patients, and the most common side effects were fatigue and mild dizziness.

If approved, larotrectinib could become the first therapy of any kind to be developed and approved simultaneously in adults and children, and the first targeted therapy to be indicated for a molecular definition of cancer that spans all traditionally-defined types of tumors. said Hyman.

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Drug Helps Fight Breast Tumors Tied to ‘Cancer Genes’ – The Tand D.com

SUNDAY, June 4, 2017 (HealthDay News) -- A twice-daily pill could help some advanced breast cancer patients avoid or delay follow-up sessions of chemotherapy, a new clinical trial reports.

The drug olaparib (Lynparza) reduced the chances of cancer progression by about 42 percent in women with breast cancer linked to BRCA1 and BRCA2 gene mutations, according to the study.

Olaparib delayed cancer progression by about three months. The drug also caused tumors to shrink in three out of five patients who received the medication, the researchers reported.

"Clearly the drug was more effective than traditional chemotherapy," said Dr. Len Lichtenfeld, deputy chief medical officer for the American Cancer Society.

"This is a group where a response is more difficult to obtain -- a young group with a more aggressive form of cancer -- and nonetheless we saw a close to 60 percent objective response rate," he said.

The study was funded by AstraZeneca, the maker of Lynparza.

Olaparib works by cutting off the avenues that malignant cancer cells use to stay alive, said lead researcher Dr. Mark Robson. He's a medical oncologist and clinic director of Clinical Genetics Service at Memorial Sloan Kettering Cancer Center in New York City.

The drug inhibits PARP, an enzyme that helps cells repair damaged DNA, Robson said.

Normal cells denied access to PARP will turn to the BRCA genes for help, since they also support the repair of damaged DNA, Robson said.

But that "backup capability" is not available to breast cancer cells in women with BRCA gene mutations, Robson said.

"When you inhibit PARP, the cell can't rescue itself," Robson said. "In theory, you should have a very targeted approach, one specifically directed at the cancers in people who have this particular inherited predisposition."

Olaparib already has been approved by the U.S. Food and Drug Administration for use in women with BRCA-related ovarian cancer. Robson and his colleagues figured that it also should be helpful in treating women with breast cancer linked to this genetic mutation.

The study included 302 patients who had breast cancer that had spread to other areas of their body (metastatic breast cancer). All of the women had an inherited BRCA mutation.

They were randomly assigned to either take olaparib twice a day or receive standard chemotherapy. All of the patients had received as many as two prior rounds of chemotherapy for their breast cancer. Women who had hormone receptor-positive cancer also had been given hormone therapy.

After 14 months of treatment, on average, people taking olaparib had a 42 percent lower risk of having their cancer progress compared with those who received another round of chemotherapy, Robson said.

The average time of cancer progression was about seven months with olaparib compared with 4.2 months with chemotherapy.

Tumors also shrank in about 60 percent of patients given olaparib. That compared with a 29 percent reduction for those on chemotherapy, the researchers said.

Severe side effects also were less common with olaparib. The drug's side effects bothered 37 percent of patients compared with half of those on chemo. The drug's most common side effects were nausea and anemia.

"There were fewer patients who discontinued treatment because of toxicity compared to those who received chemotherapy," Robson said. "Generally it was pretty well tolerated."

Only about 3 percent of breast cancers occur in people with BRCA1 and BRCA2 mutations, the researchers said in background notes.

Despite this, the results are "quite exciting," said Dr. Julie Fasano, an assistant professor of hematology and medical oncology at the Icahn School of Medicine at Mount Sinai in New York City.

Olaparib could wind up being used early in the treatment of metastatic breast cancer as an alternative to chemotherapy, and future studies might find that the drug is effective against other forms of breast cancer, Fasano said.

"It may be a practice-changing study, in terms of being able to postpone IV chemotherapy and its associated side effects" like hair loss and low white blood cell counts, Fasano said.

Lichtenfeld noted that olaparib also places less burden on patients.

"It may be easier for women to take two pills a day rather than go in for regular chemotherapy," Lichtenfeld said. "Clearly, this is a treatment that will garner considerable interest.

The findings were scheduled to be presented Sunday at the American Society of Clinical Oncology's annual meeting, in Chicago. The study was also published June 4 in the New England Journal of Medicine.

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Drug Helps Fight Breast Tumors Tied to 'Cancer Genes' - The Tand D.com

Studying Biotechnology And Microbiology For Career Building … – Good Herald

Science has multiple wings and streams and studying one of them and specializing in it can open up various career prospects for the candidates. A couple of such streams that are gaining importance and popularity are biotechnology and microbiology. Both are integral parts of biological science and both have their respective uses. Pursuing a graduation or masters degree in the field may prove extremely rewarding for the users. Many students these days are pursuing the BSc Biotechnology and higher degrees in search of building up their career graph.

Understanding Biotechnology

Biotechnology involves the use of genetic as well as biochemical processes related to the living organisms for using them for humans. There are numerous genetically modified crops in the field of agriculture and there are also multiple genetically modified vaccines in the field of healthcare and medications. In some of the leading science colleges in Dehradun particular emphasis is given to the application of the principles of biotechnology in DNA applications and cell regulation in human anatomy. While the BSc degrees offered by these colleges include basic applications in the field the MSc Biotechnology degree offers higher levels of use of the biochemical processes and their impact studies.

Work Placement and Laboratory Works

Students seeking to obtain the MSc Biotechnology degree may not find the task easy enough. There are very strong optional work placements involved and the course also includes high degrees of laboratory works. This ensures practical experience induction in the student preparing him or her to be strong enough to face all the challenges that come their way. Thus the courses are intelligent combination of theories and practices.

Biotechnology Course Components

Course components for the students studying for obtaining graduation or masters degree in biotechnology include biology, chemistry, and mathematics. Physics is not normally included but students can separately study physics and even go up to the level of passing MSc Physics. In degree courses there are no majors. Students may however opt to specialize in a subject and choose the honors course in it. Taking honors has two benefits. First it can enhance job prospects and second it would make entry into the MSc course easier.

Job Prospects in the Field

People with graduate or masters degree in biotechnology get job opportunities in a host of industries. These are pharmaceuticals, environment, agriculture, horticulture, research, and forensic science among others. Job opportunities are available in both public as well as private sectors. Consulting services, academes, research organizations and NGOs are other major job sources.

Study of Microbiology

An important wing of biotechnology is microbiology that deals with organisms in microscopic sizes. They include bacteria, viruses, protozoa and algae as well as fungi affecting the life of human beings. Studying their characteristics, impact on human anatomy and remedial solutions constitute the basic features of the MSc Microbiology.

Biotechnology is not a new invention and has been in use for over six thousand years. The technology has been used to prepare foodstuff like bread and cheese, for preservation of dairy products and also for fermenting beer. Candidates need a good college to pursue their course of BSC or MSc Microbiology or any other wing of the biotechnology. To choose the right academy the need information and a qualitative site can provide the required information for them.

Know more visit http://bfitdoon.com/

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Studying Biotechnology And Microbiology For Career Building ... - Good Herald

American Oriental Bioengineering, Inc. (AOBI) Upgraded at ValuEngine – Sports Perspectives

American Oriental Bioengineering, Inc. (AOBI) Upgraded at ValuEngine
Sports Perspectives
American Oriental Bioengineering, Inc. (OTCMKTS:AOBI) was upgraded by equities researchers at ValuEngine from a sell rating to a hold rating in a note issued to investors on Wednesday, May 24th. Shares of American Oriental Bioengineering (AOBI) ...

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American Oriental Bioengineering, Inc. (AOBI) Upgraded at ValuEngine - Sports Perspectives

A Periodic Table of Behavior for Psychology – Psychology Today (blog)


Psychology Today (blog)
A Periodic Table of Behavior for Psychology
Psychology Today (blog)
Modern science took off during the Enlightenment and changed the world. Science was differed from philosophy in that it did not presuppose how nature must be, as the early philosophers tended to do, but instead scientists got up out of their armchairs ...

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A Periodic Table of Behavior for Psychology - Psychology Today (blog)

LOOSE ENDS: Eldar Shafir on the effects scarcity – centraljersey.com

Memorial Day weekend followed by Princeton University reunions and graduation is a time when most Princeton residents rarely think about scarcity. Generally, the conversation under tents and in backyards is filled with groans about too much food, too much drink, too many people, too many cars, and too much stuff loaded into those cars.

On the weekend of June 10, however, several Princetonians are going to be thinking a lot about scarcity, thanks to Princeton University Professor Eldar Shafir. Dr. Shafir who is speaking at a Housing Initiatives of Princeton Garden Party benefit June 10 is internationally renowned, along with his co-author Dr. Sendhil Mullainathan from Harvard University, for the 2013 book "Scarcity: Why Having Too Little Means So Much."

As a behavioral scientist whose main area of interest is behavioral economics and decision-making, Shafir will talk about the thesis of his book the scarcity vicious cycle and relate it to the mission of HIP. Individuals with a scarcity of funds fail to make smart decisions concerning their finances for a variety of cognitive reasons, including the lack of supportive resources, thus their lives spiral downward. It turns out that the work done by HIP could be a case study for Shafirs academic work.

Since 2004, the Housing Initiatives of Princeton has been helping to break that downward spiral for dozens of people by offering a holistic menu of services to those in dire financial circumstances. It is dedicated to transitioning low-income working families and individuals who are homeless or facing imminent homelessness to permanent housing and sustained self-sufficiency.

The charitable non-profit does far more than place a temporary roof over ones head. The organization becomes a supportive resource for clients by providing individualized case management services to enhance life skills needed to attain self-sufficiency and permanent housing and ultimately to succeed independently.

Most in Princeton have a comfortable life," Shafir said. "We can afford to hire accountants, investment brokers, mortgage brokers, psychologists, attorneys to help make smart decisions about our well being. But there are those who are struggling with a scarcity of funds and do not have the support systems. The problems associated with poverty consume mental energy and capacity. Those struggling financially often make decisions that perpetuate and exacerbate poverty."

The concept of scarcity and smart decision-making applies to more than financial decisions, and thus everyone can relate to the premise of the book, regardless of his or her economic situation, noted HIP Interim Board Chair Carol Golden. The authors research and conclusions describe how scarcity creates a similar psychology for everyone struggling to manage with less than they need. Busy people fail to manage their time efficiently for the same reasons the poor and those maxed out on credit cards fail to manage their money. The dynamics of scarcity reveal why dieters find it hard to resist temptation, why students and busy executives mismanage their time.

The book is so significant, in my opinion, because it gives individuals who have no financial problems a real understanding as to why it is extremely difficult for people with great financial challenges to change their lives unless they have access to outside help, said Golden, a Princeton resident and attorney who volunteers her services as the full-time chair of the organization, officially known as Housing Initiatives of Princeton Charitable Trust.

Shafir further elaborated on his thesis in a research paper, Poverty Impedes Cognitive Function, published in the August 2013 issue of Science (written with Anandi Mani and Jiaying Zhao).

According to the papers summary, the poor often behave in less capable ways, which can further perpetuate poverty.

We hypothesize that poverty directly impedes cognitive function and present two studies that test this hypothesis," the authors wrote. "First, we experimentally induced thoughts about finances and found that this reduces cognitive performance among poor but not in well-off participants. Second, we examined the cognitive function of farmers over the planting cycle. We found that the same farmer shows diminished cognitive performance before harvest, when poor, as compared with after harvest, when rich.

"This cannot be explained by differences in time available, nutrition, or work effort. Nor can it be explained with stress: Although farmers do show more stress before harvest, that does not account for diminished cognitive performance. Instead, it appears that poverty itself reduces cognitive capacity. We suggest that this is because poverty-related concerns consume mental resources, leaving less for other tasks. These data provide a previously unexamined perspective and help explain a spectrum of behaviors among the poor.

As Princeton University Professor of Behavioral Science and Public Policy, Shafir, who has been working at the university for the past 25 years, also serves as the director (its inaugural director) of Princetons Kahneman-Treisman Center for Behavioral Science and Public Policy, and co-founder and scientific director at ideas42, a social science research and development lab.

A $10 million anonymous gift created theCenter for Behavioral Science and Public Policy at Princeton, enabling the university to strengthen its leading role in this emerging field and improve the development of effective policymaking. The donor, a Princeton University parent, was a longtime admirer of the work of Dr. Daniel Kahneman, a Nobel laureate, and a Princeton University professor of psychology and public affairs emeritus, and Dr. Anne Treisman, a Princeton University professor of psychology emerita.

The center is building on the research that earned Kahneman the Nobel Prize in economic sciences in 2002. The award-winning work integrated insights from psychological research into economics, particularly concerning decision making under uncertainty.

In the traditional view, policies are designed for people who make rational decisions based on thorough consideration of the options and on well-informed cost-benefit analyses," the university stated in a release announcing the gift in 2015. "In the approach pioneered at Princeton, policies are developed with a focus on what really drives people in decision making the idiosyncratic and sometimes surprising ways in which they view their choices, perceive the social, economic and political world around them, and decide whether or not, and how, to act. Why do some people spend too much and save too little, choose unhealthy diets that might shorten their lives?"

Princeton University President Christopher Eisgruber said:

This generous gift will allow us to deepen and expand our efforts in an extremely promising area of teaching and research. . . . Princetons faculty members are applying behavioral science techniques to topics that include law, economics, health care, household finance and dispute resolution, Princeton University President Christopher Eisgruber said. "We expect that the research conducted at the center will directly influence local, national and global public policy, identifying new approaches to address social problems and improve lives.

And HIP clients and supporters offer an abundance, not scarcity, of thanks for the academic work and research that will help HIP serve the community in the most effective manner possible.

The Housing Initiatives of Princeton will host its annual Garden Party, June 10, beginning at 4 p.m. at a private residence in Princeton. Admission costs $95 and features Shafir's talk, cocktails and light fare. To register, go towww.housinginitiativesofprinceton.org.

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LOOSE ENDS: Eldar Shafir on the effects scarcity - centraljersey.com

People trust science. So why don't they believe it? – WXIA-TV

Alia E. Dastagir , USA TODAY , TEGNA 12:48 PM. EDT June 02, 2017

Members of the Union for Concerned Scientists pose for photographs with Muppet character Beaker in front of The White House before heading to the National Mall for the March for Science rally in Washington, D.C. (Photo: Jessica Kourkounis, Getty Images)

Editor's note: This story was originally published in April. It has been updated to include the latest on the Paris climate agreement.

Thousands of scientists and their allies filled the streets of the nations capital onEarth Day for theMarch for Science, advocating for the importance of scientific truth in an era weve ominously been told doesnt value the truth any longer. Just a week later, the People's Climate March in Washington, D.C., demanded policymakers not only respect science, but that they also act on it.

And now, drawing global dismay and condemnation,President Trump has announced that the U.S. willno longer participate in the landmark Paris climate agreement.

Advocates say science is under attack. President Trumps Environmental Protection Agency chief Scott Pruitt doesnt accept evidence that shows humans are causing climate change.Education Secretary Betsy DeVos'2001 commentson wanting to advance Gods kingdom through education have educatorsworried she could undermine the teaching of evolution in public schools.Trumps budget blueprint slashes funding for the National Institutes of Health and the Department of Energy's Office of Science.

Esteemed astrophysicist Neil deGrasse Tyson, in an impassioned video on hisFacebook page, said he fears people have lost the ability to judge what's true and what's not.

"That is a recipe for the complete dismantling of our informed democracy," he says.

The scientific community is alarmed by the Trump administration, and by whatthey see as the diminishing role of objectivescience in American life. But theGeneral Social Survey, one of the oldest and most comprehensive recurring surveys of American attitudes, shows that although trust in public institutions has declined over the last half century, science is the one institution that has not suffered any erosion of public confidence. Americans who say they have a great deal of confidence in science has hovered around 40% since 1973.

Many scientists say there is no war on their profession at all.

According to the 2016 GSS data released this month, people trust scientists more than Congress (6%) and the executive branch (12%). They trust them more than the press (8%). They have more trust in scientists than in the people who run major companies (18%), more than in banks and financial institutions (14%), the Supreme Court (26%) or organized religion (20%).

So why all the headlines about the "war on science"?

Though science still holds an esteemed place in America, there isa gapbetween what scientists and some citizens think a rift that is not entirely new on issues such as climate change, nuclear power, genetically modified foods, human evolution and childhood vaccines.

Americans dont reject science as a whole. People love the weather forecast. They love their smartphones. When people reject science, its because theyre asked to believe something that conflicts with a deeply held view, whether political (myparty does not endorse that), religious (my god didnot say that) or personal (that's not how I was raised).

Manyconservatives reject the science of man-madeclimate change, just as manyliberals reject the science that shows nuclear energy can safely combat it. The views we express signal which politicalgroup we belong to. The gap between what science shows and what people believe, sociologists say, is about our identity.

The issue of climate change isnt about what you know, said Dan Kahan, a professor of psychology and law at Yale and a member of the universitysCultural CognitionProject. Its about who you are.

Polarization has exacerbated our differences, andwe know some of whats to blame:Therise of social media. A more partisan press. A dearth of universally-accepted experts. And greater access to information, which Christopher Graves, president and founder of the Ogilvy Center forBehavioralScience, said does not tug us toward the center, but rather makes us more polarized.

A human being cannot grasp something as a fact if it in any way undermines their identity, Graves said. And that is animmutable human foible. These things have always been there, but not at scale."

The GSS data show confidence in institutions overall has been in decline since the 1970s, though political scientists are quick to caution that this is animperfect benchmark.

Brendan Nyhan, a political scientist atDartmouth College, said trust in the mid-20th century was unnaturally high and polarization was unnaturally low,bolstered by unusual growth in middle class income and a reduction of inequality, which is when the "20th century version of the American dream and the trust in government to produce it was fully mythologized."

There was an usually high level of trust that came out of World War II, before the turn towards a more cynical view ofthe institutions of society especially politics and media after Vietnam and Watergate,"Nyhan said.

So how much more polarization can we expect?

Social scientists aren't sure, but they agreeTrump complicates things.

"He really is an us-versus-them figure," Kahan said. "People arent thinking about the arguments. Theyre thinkingaboutwhat side they're on."

Think about the way you search for information. If youre a new mom who believes vaccines cause autism (and a number of women in your mommy group do, too) are you searching for research that shows whether they actually do, or are you Googling vaccines cause autism to find stories to affirm your belief? (Studies show there isno link between vaccines and autism.)

The mother above is probably motivated by fear. Suchmotivated reasoning,says political scientistCharles Taberof Stony Brook University, shows that we are all fundamentally biased.

You have a basic psychological tendency to perpetuate your own beliefs, he said to really discount anything that runs against your own prior views.

It gets even more complicated.Once weve convinced ourselves of something, research suggests factsdont appeal to us.A studyco-led by Nyhanfound that trying to correct a persons misperception can have a backfire effect. When you encounter facts that dont support your idea, your belief in that idea actually grows stronger.

So what if we did a better job teaching people how science works? Doesn't help, Kahan said. Research shows peoplewith the most science intelligence are also the most partisan.

Its not knowledge but curiosity, Kahan says, that makes us more likely to accept scientific truths. Arecent studythat Kahan led found people with more scientific curiosity were more likely to be open-minded about information that challenged their existing political views.

And arguing helps, too. ScientistsHugo Mercier and Dan Sperber contend in their new book,The Enigma of Reason,that reason isn't somethingthat evolved sohumans could solve problems on their own. It developed so we could work together.

Instead of forcing someone to agree that climate change is caused by humans, Graves said, you can stop once you agree that, for example, flooding in Florida is a problem, and that you have to fix it (the bipart
isanSoutheast Florida Regional Climate Change Compactcan teach us about that).

Marcia McNutt, an American geophysicist and president of the National Academy of Sciences, said she isnt worried about a crisis of science, though she hopes more people would understand science is about the unbiased search for truth" and that benefits everyone.

Being a scientist only means that when I have an intuition about something, I test that intuition, and see if Im right, she said. A very, very smart mentor told me once, I don't trust anyone who hasn't at least changed their mind once in their career.

Science, it appears, may havemore lessons for usthan we think.

2017 USATODAY.COM

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People trust science. So why don't they believe it? - WXIA-TV

Theater Review | I Do! I Do!: Topnotch performers, genuine chemistry make musical believable – The Columbus Dispatch

By Michael Grossberg For The Columbus Dispatch

I Do! I Do!, a mid-1960s Broadway vehicle for Mary Martin and Robert Preston, is rarely revived these days.

Yet, thanks to the warm humor and affectionate sweetness of two topnotch performers, CATCO makes a sentimental case for the musicals old-fashioned portrait of a 50-year marriage. CATCOs season finale, which opened Friday in the Riffe Centers Studio Two Theatre, finds its heart in a husband-wife team of veteran actors.

Joe Bishara and Liz Wheeler have an easy comfort level and noticeably genuine chemistry with each other that naturally anchors their performances throughout the two-character, two-act, two-hour show. As Michael and Agnes Snow, the pair build an amusing, touching and convincing relationship from wedding night until well past honeymoon's end.

Bishara embodies Michaels initial romantic idealism but also his flaws, from unconscious arrogance and a writers self-absorption to a male chauvinism more common (and less disturbing) generations ago. Wheeler shapes a compelling arc from the girlish nervousness of a nave bride to the greater maturity of a patient housewife and mother. Well, patient up to a point.

Director Steven C. Anderson trusts the material, even when its quaint, and guides the performers to highlight the gentle humor and lilting melodies.

The singing is especially lovely in My Cup Runneth Over, the stand-out hit from the tuneful score by The Fantasticks team of composer Harvey Schmidt and author-lyricist Tom Jones. But the duet Nobodys Perfect has greater comic impact because the lyrics ring true.

Wheeler revels in the flamboyant opportunities for comic melodrama in Flaming Agnes, a revenge fantasy that follows Michaels confession of adultery. (Today, though, the song seems to trivialize the betrayal, as if men will be men and women should put up with them at their worst.)

Parental issues enliven the shorter second act, whose highlights include Michaels funny The Father of the Bride and the wish-fulfillment duet When the Kids Get Married.

Music director Quinton Jones expertly backs the performers on piano, visible behind a translucent rear grid and four movable cushioned squares of furniture that combine to form the couples four-poster bed.

The crisp staging and abstracted scenic design - by Darin Keesing, with golden-hued lighting by Cynthia Stillings - helps make the somewhat dated script seem timeless, or at least not as obviously rooted in the shows original era (1895-1945). Such rueful comedy-drama, about the predictable but comforting rites of lifes passages, sparks laughs of recognition as well as sighs.

Older couples, in particular, are likely to appreciate this musical the most because theyve lived through much of it.

mgrossberg1@gmail.com @mgrossberg1

CATCO will present I Do! I Do! at 8 p.m. Saturday, 2 p.m. Sunday, 11 a.m. Wednesday, 8 p.m. Thursday through June 10, 2 p.m. June 11, 11 a.m. June 14, 8 p.m. June 15-17 and 2 p.m. June 18 in the Riffe Centers Studio Two Theatre, 77 S. High St. Tickets cost $40 Fridays and Saturdays, or $35 Sundays, $30 Thursdays, $20 Wednesdays, $15 for students two hours before showtime. Call 614-469-0939 or visit http://www.catcoistheatre.org

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Theater Review | I Do! I Do!: Topnotch performers, genuine chemistry make musical believable - The Columbus Dispatch

Behavioral science hacks for your next speaking opportunity – SmartBrief (registration) (blog)


SmartBrief (registration) (blog)
Behavioral science hacks for your next speaking opportunity
SmartBrief (registration) (blog)
I was giving a presentation on behavioral science and customer experience at the end of a long conference. Sure, I could've hit my listeners over the head with an academic discourse on predicted utility versus value-seeking, but showing it drove the ...

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