Author Archives: ev1

Animal physiologist Ari van Tienhoven dies at 91

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Feb. 6, 2014

Ari van Tienhoven, emeritus professor of animal physiology in the College of Agriculture and Life Sciences, died Jan. 31. He was 91.

Born April 22, 1922, in The Hague, Netherlands, van Tienhoven came to the United States in 1947, joined the poultry and avian sciences faculty in 1955 and became a U.S. citizen in 1959.

An internationally recognized authority on animal physiology and particularly animal reproduction, van Tienhoven compiled with others an extensive revision of Sydney A. Asdells widely used reference, Patterns of Mammalian Reproduction.

In 1970 he aroused controversy by advocating that humans limit their reproduction to forestall overpopulation. He taught an AIDS and Society class from 1989 to 1992.

Librarians remember him as an avid user of Mann Library, coming in every morning of the work week to read the paper and current journals and do research. He donated extensively to the library. He established in the name of his wife the Ans van Tienhoven Award, a $1,000 stipend presented annually to a Mann librarian for travel and professional development, as well as other endowments in her name.

His wife predeceased him in 2005. They had three children and several grandchildren.

Services will be private. In lieu of flowers, donations to the van Tienhoven travel fund can be sent to Cornell Library, Alumni Affairs and Development, 130 E. Seneca St., Ithaca, NY 14850.Donors should indicate the Ans van Tienhoven Endowment Fund at Mann Library.

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Animal physiologist Ari van Tienhoven dies at 91

TAF Academy fair shows science with the latest twist

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Olyvia Salter, a junior at the Technology Access Foundation Academy, examines a fuel she made out of bio-ethanol materials at the academys science fair in Kent last Saturday.

image credit: Ross Coyle/Kent Reporter

While powering an electronic with fruit might be unconventional, it could also be a wave of the future, if the students at the The Technology Access Foundation (TAF) Academy go on to get degrees in science and technology.

The TAF Academy, a science, engineering, technology and mathematics school in Kent, hosted its fifth annual science fair last Saturday. The fair focused on student projects that investigated a multitude of different scientific disciplines. Environmental science, energy and transportation, behavioral science and computer science and robotics were just a few of the areas students featured projects in.

One students project looked at whether men or women have better short term memories (spoilers: women do) while another project used bio-electricity in fruit to generate power for LED lights.

Sophomore Favour Orji created a software system that would help recently released inmates find transitional housing. Her father's work with transitional housing strongly influenced her choice of project.

"I love it here," she said. "When I came here in the sixth grade, I wouldn't have imagined doing something like this."

The Academy opened its doors six years ago to sixth-graders and has gradually expanded to include grades seven to 12. It makes its home in Kent, but is a part of the Federal Way School District.

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TAF Academy fair shows science with the latest twist

Behavioral economics is focus of new MPS program

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Feb. 6, 2014

The role psychology and economics jointly play in decisions about food, public health, personal finance and sustainability will be examined in a newly accredited MPS (Master of Professional Studies) in Applied Behavioral Economics and Individual Choice, offered by the Charles H. Dyson School of Applied Economics and Management in Cornells College of Agriculture and Life Sciences.

Cornells newest MPS program is a chance to work with faculty members whose quirky experiments (like Brian Wansinks Bottomless Soup Bowl) lead to fundamental improvements in school lunchrooms (David R. Just) across the country; who wonder why label-reading shoppers continue to buy junk food (Harry Kaiser); and whose analyses track property values near Superfund cleanup sites (William Schulze). Other key faculty include Vicki L. Bogan, associate professor of applied economics and management, and Jurate Liaukonyte, assistant professor of applied economics and management.

Behavioral economics is a relatively new science with a distinguished history at Cornell, said Just, associate professor and director of the Cornell Center for Behavioral Economics in Child Nutrition. He points to research pioneers like Richard Thaler (formerly in the Samuel Curtis Johnson Graduate School of Management), who is universally regarded as a founder of the discipline, and Thomas Gilovich, Cornells Irene Blecker Rosenfeld Professor of Psychology, who is a widely acknowledged expert in the psychology of everyday judgment and decision-making.

Now were ready to build on this reputation by training a new generation of business and policy decision-makers, said Just. Students in the two-semester masters program can choose among three concentrations: behavioral marketing, sustainability and behavior, or behavioral finance.

Applicants to the MPS program are expected to come from undergraduate backgrounds ranging from nutrition, psychology and marketing to economics and business, Just said, but were prepared to be surprised. We will consider anyone who is curious about why people make the decisions they do, and who wants to change the way the world thinks about food marketing, consumer research, consumer research and public policy.

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Behavioral economics is focus of new MPS program

14 Month Results After Stem Cell Therapy by Dr Harry Adelson for Arthritic Hip – Video

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14 Month Results After Stem Cell Therapy by Dr Harry Adelson for Arthritic Hip
http://www.docereclinics 14 months after stem cell therapy for his arthritic hip, Marty discusses his results by Dr. Harry Adelson. Call the clinic today at ...

By: Harry Adelson, N.D.

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14 Month Results After Stem Cell Therapy by Dr Harry Adelson for Arthritic Hip - Video

Joseph Purita, M.D. of Global Stem Cells Group, Inc. Featured Speaker at 21st Annual World Congress on Anti-Aging …

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Las Vegas, NV (PRWEB) February 05, 2014

Global Stem Cells Group, Inc. and affiliate Stem Cell Training, Inc. were represented by Josepth Purita, M.D. at the 21st Annual World Congress on Anti-Aging, Regenerative and Aesthetic Medicine in Las Vegas, Dec. 15, 2013. Purita, a lead trainer for Stem Cell Training, Inc. and a pioneer in the use of stem cell therapies in orthopedics, addressed more than 5,000 conference attendees with his presentation titled, Cutting Edge Concepts for the Regenerative Medicine Physician in the Use of Stem Cell & PRP Injections.

The record number of attendees gathered from around the world at the Venetian/Palazzo Resort in Las Vegas for three days to attend the prestigious conference hosted by the American Academy of Anti-aging Medicine. The conference featured physicians and medical personnel who practice and manage stem cell technology, certification, and pellet therapy to discuss brain health and offer case studies. Workshops on personalized lifestyle medicine and aesthetic medicine were also held.

Purita was joined by an illustrious group of speakers including: Author Judith Reichman, M.D., womens health care expert and specialist in gynecology, infertility and menopause; Travis Stork, M.D., ER physician and host of the Emmy Award-winning talk show, The Doctors; and Actress and Author Suzanne Somers, a dedicated health advocate and proponent of alternative and integrative medicine.

Former California Gov. Arnold Schwarzenegger accepted the 2013 A4M Infinity Award at Saturday afternoons general session for his progressive leadership role in early funding and support of stem cell research and healthcare reform. Somers presentation Our Time Has Come, discussing the medical needs of the rapidly aging baby-boom population. Stork, host of the Emmy-Award-winning medical talk show The Doctors, discussed long-term health in a speech called Your Best Life. Reichmans presentation titled Slow Your Clock Down: On- Label, Off- Label, Gray- Label, discussed the importance on maintain balance and living a healthy lifestyle.

For more information on the World Congress on Anti-Aging, Regenerative and Aesthetic Medicine, plus upcoming conferences and training programs around the world, visit the A4M website, email, bnovas(at)regenestem(dot)com or call 849.943.2988.

About the Global Stem Cell Group:

Global Stem Cells Group, Inc. is the parent company of six wholly owned operating companies dedicated entirely to stem cell research, training, products and solutions. Founded in 2012, the company combines dedicated researchers, physician and patient educators and solution providers with the shared goal of meeting the growing worldwide need for leading edge stem cell treatments and solutions. With a singular focus on this exciting new area of medical research, Global Stem Cells Group and its subsidiaries are uniquely positioned to become global leaders in cellular medicine.

Global Stem Cells Groups corporate mission is to make the promise of stem cell medicine a reality for patients around the world. With each of GSCGs six operating companies focused on a separate research-based mission, the result is a global network of state-of-the-art stem cell treatments.

The Global Stem Cell Foundation was formed as a nonprofit charitable organization that aims to fund research on the expanding need for stem cell solutions for patients, and identify best practices between physicians engaged in stem cell treatments in the U.S. and around the world.

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Joseph Purita, M.D. of Global Stem Cells Group, Inc. Featured Speaker at 21st Annual World Congress on Anti-Aging ...

Cybernetics, Teleportation, and TransEvolution of Humanity with Daniel Estulin – Video

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Cybernetics, Teleportation, and TransEvolution of Humanity with Daniel Estulin
TransEvolution and the imminent cybernetic future where artificial intelligence, life extensions, brain enhancement, genetic engineering, and teleportation w...

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Cybernetics, Teleportation, and TransEvolution of Humanity with Daniel Estulin - Video

Articles from groundbreaking new Violence and Gender journal published

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PUBLIC RELEASE DATE:

5-Feb-2014

Contact: Kathryn Ruehle kruehle@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, February 5, 2014Mary Ann Liebert, Inc., publishers has announced the publication of six articles from Violence and Gender, a new peer-reviewed journal dedicated to the understanding, prediction, and prevention of violence and spearheaded by Mary Ellen O'Toole, PhD, Forensic Behavioral Consultant and Senior FBI Profiler/Criminal Investigative Analyst (ret.). The Journal is the international forum for the critical examination of biological, genetic, behavioral, psychological, racial, ethnic, and cultural factors as they relate to the gender of perpetrators of violence, and explores the difficult issues that are vital to threat assessment and violence prevention. The articles are available free on the Violence and Gender website at http://www.liebertpub.com/vio.

Among the published articles is "Why Do Young Males Attack Schools? Seven Discipline Leaders Share Their Perspectives," which offers an unprecedented look into the reasons for the high incidence of school shootings in the U.S., and addresses the reasons we see mostly young males (15-29) committing these types of crimes. The article delves into what motivates these perpetrators, including the potential role of the copycat phenomenon in behavior. Sharing their perspectives are world-renowned experts Jorge Folino, MD, PhD, National University of La Plata (Buenos Aires Province, Argentina); James Garbarino, PhD, Loyola University Chicago (IL); Steven Gorelick, PhD, Hunter College, City University of New York (New York, NY); Helin Hkknen-Nyholm, PhD, PsyJuridica Ltd. (Espoo, Finland); J. Reid Meloy, PhD, University of California, San Diego (La Jolla, CA); Stanton Samenow, PhD, Alexandria, VA; and Yuki S. Nishimura, MD, PhD, Keio University (Yokohama City, Japan).

"Violence is complicated, and too often misunderstood, myth-based, and stereotyped; we are shocked when we see the 'nice guy' next door arrested for serial murder, or the quiet loner go on a shooting rampage," says Dr. O'Toole. "Many of us even default to using terms like 'monster' and 'evil' to explain such behavior and the people responsible. These archaic terms don't educate us or explain the violence but rather catapult us back in time. It's time for change in how we view violence."

Other published articles include an insightful roundtable discussion with Christopher Kilmartin, PhD, University of Mary Washington (Fredericksburg, VA), and Col. Jeffery M. Peterson, USMC (ret.) and Center for Naval Analyses (Alexandria, VA), entitled "Sexual Assault in the Military: A Discussion of the Current Status and Future Prevention;" the Review article "The Mission-Oriented Shooter: A New Type of Mass Killer," by Editor-in-Chief Mary Ellen O'Toole, PhD; and a Perspective entitled "Understanding Brain Health Can Prevent Another Sandy Hook Shooting," by Jeremy Richman, PhD, Founder and CEO of The Avielle Foundation (Sandy Hook, CT).

"The imperative for this journal is urgent," said publisher Mary Ann Liebert, "we must stem the tide, and the papers in Violence and Gender have a most important mandate."

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The full inaugural issue of Violence and Gender will be published in Spring 2014.

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Articles from groundbreaking new Violence and Gender journal published

Can Genetic Engineering Mitigate California’s Drought?

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STANFORD, CA Water is in increasingly short supply in many parts of the United States. Here in California, where most of the state is experiencing extreme drought, 2013 was the driest year on record, and we have had no relief during what should be the height of the rainy season. Moreover, theres no end in sight: The Climate Prediction Center of the National Weather Serviceforecaststhat the drought will persist or intensify at least through April.

Reservoir levels are dropping, the snow pack is almost nonexistent, and many communities have already imposed restrictions on water usage. In the city of Santa Cruz, for example, restaurants can no longer serve drinking water unless diners specifically request it; Marin County residents have been asked not to clean their cars or to do so only at eco-friendly car washes; and there are limitations on watering lawns in towns in Mendocino County.

But it is the states premier industry farming that will feel the pinch most. In an average year, farmers use 80 percent of the water used by people and businesses, according to the Department of Water Resources.

During a January 19 press conference at which he declared a water emergency, Governor Jerry Brown said of the drought, This is not a partisan adversary. This is Mother Nature. We have to get on natures side and not abuse the resources that we have.

Drought may not be partisan, but it does raise critical issues of governance, public policyand how best to use the states natural resources. It also offers an example of the Law of Unintended Consequences: Ironically, Santa Cruz, Mendocino and Marin counties all of which boast politically correct, far-left politics are among the local jurisdictions that have banned a key technology that could conserve huge amounts of water.

The technology is genetic engineering performed with modern molecular techniques, sometimes referred to as genetic modification (GM) or gene-splicing, which enables plant breeders to make old crop plants do spectacular new things, including conserve water. In the United States and about 30 other countries, farmers are using genetically engineered crop varieties to produce higher yields, with lower inputs and reduced impact on the environment.

Even with R&D being hampered by resistance from activists and discouraged by governmental over-regulation, genetically engineered crop varieties are slowly but surely trickling out of the development pipeline in many parts of the world. Cumulatively, over 3.7 billion acres of them have been cultivated by more than 17 million farmers in 30 countries during the past 15 years without disrupting a single ecosystem or causing so much as a tummy ache in a consumer.

Most of these new varieties are designed to be resistant to herbicides, so that farmers can adopt more environment-friendly no-till farming practices and more benign herbicides; or to be resistant to pests and diseases that ravage crops. Others possess improved nutritional quality. But the greatest boon of all both to food security and to the environment in the long term will likely be the ability of new crop varieties to tolerate periods of drought and other water-related stresses. Where water is unavailable for irrigation, the development of crop varieties able to grow under conditions of low moisture or temporary drought could both boost yields and lengthen the time that farmland is productive.

Even where irrigation is feasible, plants that use water more efficiently are needed. Because irrigation for agriculture accounts for roughly 70 percent of the worlds fresh water consumption, the introduction of plants that grow with less water would allow much of it to be freed up for other uses. Especially during drought conditions, even a small percentage reduction in the use of water for irrigation could result in huge benefits.

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Can Genetic Engineering Mitigate California's Drought?

Is the male or female brain more vulnerable to triggers of violent behavior?

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PUBLIC RELEASE DATE:

5-Feb-2014

Contact: Kathryn Ruehle kruehle@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, February 5, 2014Human behaviors such as violence depend on interactions in the brain between genetic and environmental factors. An individual may be more vulnerable to developing violent behaviors if they have predisposing factors and are then exposed to stress, abuse, or other triggers, especially early in life. The latest research on how differences between the male and female brain contribute to sex differences in violence is explored in Violence and Gender, a new peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Violence and Gender website at http://www.liebertpub.com/vio.

The article "Not Hardwired: The Complex Neurobiology of Sex Differences in Violence" describes the complex and flexible biological mechanisms in the brain that lead to the development of behaviors. These include interconnected neural networks, multiple genes, and chemical signals such as hormones and neurotransmitters, which can be modified by environmental factors. Brain structure, function, and connectivity can all differ between men and women, affecting how they may change on exposure to stressful or abusive triggers.

"Neurobiologist Dr. Debra Niehoff explains the amazing interaction of how our brains, genetics, and environmental influences can interact and serve as the genesis for violent behavior," says Editor-in-Chief of Violence and Gender Mary Ellen O'Toole, PhD, Forensic Behavioral Consultant, and Senior FBI Profiler/Criminal Investigator Analyst (ret.). "This holistic view of the origin of violence means that reducing violence will not be a simple fix because it does not have a single origin or cause. The temptation to delineate a male and female brain must be resisted because there is overlap between the two. With more research will come greater insight and knowledge about the biological and environmental causes of violence. With more knowledge will come answers; answers will lead to solutions, and with solutions will come prevention."

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About the Journal

Violence and Gender is the only peer-reviewed journal focusing on the understanding, prediction, and prevention of acts of violence. Through research papers, roundtable discussions, case studies, and other original content, the Journal critically examines biological, genetic, behavioral, psychological, racial, ethnic, and cultural factors as they relate to the gender of perpetrators of violence. Led by Editor-in-Chief Mary Ellen O'Toole, PhD, Forensic Behavioral Consultant and Senior FBI Profiler/Criminal Investigative Analyst (ret.), Violence and Gender explores the difficult issues that are vital to threat assessment and prevention of the epidemic of violence. Violence and Gender is published quarterly online with Open Access options and in print, and is the official journal of The Avielle Foundation.

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Is the male or female brain more vulnerable to triggers of violent behavior?

READER SUBMITTED: Quinnipiac University Psychology Professor Receives $60,000 Young Investigator Grant

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Adrienne Betz. (Mark Stanczak / January 29, 2014)

12:10 p.m. EST, February 5, 2014

"I am honored to have been selected and look forward to contributing research aimed at discovering better treatments for mood disorders through scientific discovery in my lab," she said. "They only fund scientists whose research is reviewed and recommended by a world-renowned scientific council including Nobel Prize winners and chairs of psychiatric departments."

The $60,000 award will enable Betz to continue her research into Major Depressive Disorders (MDD) by examining the molecular mechanisms of stress on the hippocampus, a major part of the brain. Her research will investigate several areas of undeveloped inquiry, thereby helping to elucidate the molecular underpinnings of MDD.

"These experiments, funded by the Young Investigator award, will provide important information about potential mechanisms underlying persistent effects of chronic stress exposure in brain regions relevant to MDD," said Betz, who also expressed gratitude to Mark Yeckel, professor of medical sciences at Quinnipiac's Frank H. Netter MD School of Medicine, for serving as her scientific mentor on the grant.

Betz earned bachelor's, master's and doctorate degrees in psychology/neuroscience from the University of Connecticut. She served as a fellow, associate and affiliate in molecular psychiatry at Yale University. She taught psychology at UConn and Southern Connecticut State University before joining Quinnipiac in 2009.

"Being at Quinnipiac University has afforded me the unique opportunity to mentor students while engaging in serious scientific research," Betz said. "This grant will help me establish a fully sustainable and fundable laboratory and will have a profound impact on my work at Quinnipiac by allowing me to continue high-caliber research, and will be a catalyst in helping me achieve my goals".

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READER SUBMITTED: Quinnipiac University Psychology Professor Receives $60,000 Young Investigator Grant

In Vitro Innovation: Testing Nanomedicine With Blood Cells On A Microchip

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Newswise Designing nanomedicine to combat diseases is a hot area of scientific research, primarily for treating cancer, but very little is known in the context of atherosclerotic disease. Scientists have engineered a microchip coated with blood vessel cells to learn more about the conditions under which nanoparticles accumulate in the plaque-filled arteries of patients with atherosclerosis, the underlying cause of myocardial infarction and stroke.

In the research, microchips were coated with a thin layer of endothelial cells, which make up the interior surface of blood vessels. In healthy blood vessels, endothelial cells act as a barrier to keep foreign objects out of the bloodstream. But at sites prone to atherosclerosis, the endothelial barrier breaks down, allowing things to move in and out of arteries that shouldnt.

In a new study, nanoparticles were able to cross the endothelial cell layer on the microchip under conditions that mimic the permeable layer in atherosclerosis. The results on the microfluidic device correlated well with nanoparticle accumulation in the arteries of an animal model with atherosclerosis, demonstrating the devices capability to help screen nanoparticles and optimize their design.

Its a simple model a microchip, not cell culture dish which means that a simple endothelialized microchip with microelectrodes can show some yet important prediction of whats happening in a large animal model, said YongTae (Tony) Kim, an assistant professor in bioengineering in the George W. Woodruff School of Mechanical Engineering at the Georgia Institute of Technology.

The research was published in January online in the journal Proceedings of the National Academy of Sciences. This work represents a multidisciplinary effort of researchers that are collaborating within the Program of Excellence in Nanotechnology funded by the National Heart, Lung, and Blood Institute, the National Institutes of Health (NIH). The team includes researchers at the David H. Koch Institute for Integrative Cancer Research at MIT, the Icahn School of Medicine at Mount Sinai, the Academic Medical Center in Amsterdam, Kyushu Institute of Technology in Japan, and the Boston University School of Medicine and Harvard Medical School.

Kim began the work as his post-doctoral fellow at the Massachusetts Institute of Technology (MIT) in the lab of Robert Langer.

This is a wonderful example of developing a novel nanotechnology approach to address an important medical problem, said Robert Langer, the David H. Koch Institute Professor at Massachusetts Institute of Technology, who is renowned for his work in tissue engineering and drug delivery.

Kim and Langer teamed up with researchers from Icahn School of Medicine at Mount Sinai in New York. Mark Lobatto, co-lead author works in the laboratories of Willem Mulder, an expert in cardiovascular nanomedicine and Zahi Fayad, the director of Mount Sinais Translational and Molecular Imaging Institute.

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In Vitro Innovation: Testing Nanomedicine With Blood Cells On A Microchip

stem cell therapy treatment for traumatic brain injury by dr alok sharma, mumbai, india – Video

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stem cell therapy treatment for traumatic brain injury by dr alok sharma, mumbai, india
improvement seen in just 5 days after stem cell therapy treatment for traumatic brain injury by dr alok sharma, mumbai, india. Stem Cell Therapy done date 7 ...

By: Neurogen Brain and Spine Institute

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stem cell therapy treatment for traumatic brain injury by dr alok sharma, mumbai, india - Video

Stem cell treatment: Controversial for humans, but not for pets

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PHOENIX, Ariz. -

Stem cell research and therapy on humans has traveled a long and often politically troubled path.

Not so for pets, where stem cell treatment has been used for nearly 10 years and now it is so routine, and so successful, it can be done in a day.

Ava is a 90 pound, 2-year-old Akita, who is about to undergo stem cell surgery. A little IV, a little anesthesia and Ava is out.

"It is used for arthritis mostly," said Dr. Velvet Edwards.

Ava is just beginning her day at Pecan Grove Veterinary Hospital in Tempe. Dr. Edwards oversees the stem cell procedure.

"Stem cells are healing cells, so they seek out area of injury damage or destruction," explained Edwards. "They accelerate healing and help the animal, the patient, the pet just use their own natural abilities to get better."

Veterinary stem cells are harvested from the animal's own fat cells. They are separated and processed by machinery right inside the vet's office and then injected back into the dog's trouble spots.

Thanks to new technology developed by Meti Vet, the process is completed in just a day.

"The pet comes in the morning, it's anesthetized and I collect about two to four grams of fat usually behind the shoulder blade," said Edwards. "Then I hand that fat over to my technicians to run it through a series of steps.. basically to dissolve the fat and get down to a little stem cell pellet... Then we take that pellet and we reconstitute it and make it injectable. I will put it back into the animal's body wherever I need it later that day."

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Stem cell treatment: Controversial for humans, but not for pets

TiGenix : reaches major cell therapy milestone with 1000th.

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REGULATED INFORMATION FEBRUARY 4, 2014

TiGenix reaches major cell therapy milestone with 1000th implant of ChondroCelect

Leuven (BELGIUM) - February 4, 2014 - TiGenix (NYSE Euronext: TIG), a leader in the field of cell therapy, announced today that it reached a major milestone with the performance of the 1000th ChondroCelect implantation for cartilage repair in the knee. ChondroCelect is the first cell therapy that was granted approval by the European Medicines Agency (EMA) as an Advanced Therapy Medicinal Product (ATMP). Today it is routinely used in orthopedic centers of excellence across several European countries.

"A 1000 patients have already benefited from this innovative therapy, further supporting its efficacy and safety profile," said Eduardo Bravo, CEO of TiGenix. "A milestone such as today's is a clear demonstration of how far the cell therapy field has progressed over recent years, and I have no doubt that it is on its way to become a mainstay in clinical practice. We will continue to work towards turning our ChondroCelect franchise into a cash flow positive asset, and to push the clinical development of our pipeline of stem cell programs to a successful conclusion."

About ChondroCelect An innovative treatment, ChondroCelect has been shown to result in long-term durable clinical benefits in patients with recent cartilage lesions. Five-year follow-up data confirm that the therapeutic effect and the clinical benefit of ChondroCelect gained over baseline is maintained up to at least five years after the cartilage repair intervention. In addition, the data confirm that early treatment with ChondroCelect results in a superior clinical benefit over microfracture, and a lower failure rate.

Cartilage lesions of the knee are a frequent cause of disability in the active population. Caused by repetitive microtraumata, or due to sports or traffic accidents, cartilage lesions rarely heal spontaneously. When untreated, they predispose to osteoarthritis, which causes disability and represents a major socioeconomic burden. A treatment that allows symptom relief and functional recovery is key. To meet this important medical need, TiGenix developed ChondroCelect, the first cell therapy that was granted approval by the EMA as an ATMP.

ChondroCelect is administered to patients in an autologous chondrocyte implantation procedure known as Characterized Chondrocyte Implantation. TiGenix has designed a sophisticated manufacturing process to preserve the cells' characteristics and biological activity, and to maintain their ability to produce high quality cartilage. This process meets the highest quality standards and has been approved by the EMA.

For more information: Eduardo Bravo Chief Executive Officer eduardo.bravo@tigenix.com

Claudia D'Augusta Chief Financial Officer claudia.daugusta@tigenix.com

About TiGenix

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TiGenix : reaches major cell therapy milestone with 1000th.

Biomechanics & physiology tests by Portugal Rowing Team w/ K4b2 @ Porto Biomechanics Laboratory – Video

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Biomechanics physiology tests by Portugal Rowing Team w/ K4b2 @ Porto Biomechanics Laboratory
Source: Porto Biomechanics Laboratory (LABIOMEP) http://www.labiomep.up.pt Check COSMED website: http://www.cosmed.com/en/products/cardio-pulmonary-exercise-testing...

By: COSMED Cardiopulmonary Diagnostics

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Biomechanics & physiology tests by Portugal Rowing Team w/ K4b2 @ Porto Biomechanics Laboratory - Video