Human Genetic Engineering Begins! – National Review

Some of the most powerful technologies ever invented whichcan literally change human life at the DNAlevel aremoving forward with very little societal discussion or sufficient regulatory oversight. Technology Review is now reporting an attempt in the US to use CRISPR to genetically modify a human embryo. From the story:

The first known attempt at creating genetically modified human embryos in the United States has been carried out by a team of researchers in Portland, Oregon,Technology Reviewhas learned.

The effort, led by Shoukhrat Mitalipov of Oregon Health and Science University, involved changing the DNA of a large number of one-cell embryos with the gene-editing technique CRISPR, according to people familiar with the scientific results

Now Mitalipov is believed to have broken new ground both in the number of embryos experimented upon and by demonstrating that it is possible to safely and efficiently correct defective genes that cause inherited diseases.

Although none of the embryos were allowed to develop for more than a few daysand there was never any intention of implanting them into a wombthe experiments are a milestone on what may prove to be an inevitable journey toward the birth of the first genetically modified humans.

It may begin with curing disease. But it wont stay there. Many are drooling to engage in eugenic genetic enhancements.

So, are we going to just watch, slack-jawed, the double-time marchto Brave New World unfoldbefore our eyes?

Or are we going to engage democratic deliberation to determine if this should be done, and if so, what the parameters are?

Considering recent history, I fear I know the answer.

And NO: I dont trust the scientists to regulate themselves.

Mr. President: We need a presidential bioethics/biotechnology commission now!

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Human Genetic Engineering Begins! - National Review

Scientists, theologians ponder if biology and religion go together – Crux: Covering all things Catholic

OXFORD, England When Charles Darwin published his landmark theory of evolution by natural selection in the 19th century, religious leaders were confronted with a powerful challenge to some of their oldest beliefs about the origins of life.

Then evolutionary theory was expanded with the insights of genetics, which gave further support for a scientific and secular view of how humans evolved.

Faith and tradition were forced further onto the defensive.

Now, exciting progress in biology in recent decades may be building up a third new phase in the scientific explanation of life, according to thinkers gathered at a University of Oxford conference last week (July 19-22).

Although this 21st-century wave has no single discovery to mark its arrival, new insights into developing technologies such as genetic engineering and human enhancement may end up giving another important boost to the belief that science has (or eventually will have) the answers to lifes mysteries.

Some scientists, theologians and philosophers see in this ever deeper knowledge of how genes work a possible alternative to the more reductive approach to evolution one that brings in a broader view that also considers the influence of the environment.

Dr. Donovan Schaefer. (Credit: Photo courtesy of University of Oxford.)

Unlike the earlier views, which seemed to lead toward either agnosticism or atheism, the theologians see this new biology or holistic biology as more compatible with religious belief.

Weve added definition to the picture of evolution that has deepened and enriched our understanding of biological processes, Donovan Schaefer, an Oxford lecturer in science and religion who co-organized the conference, told the opening session of the July 19-22 meeting.

But he added: It would be naive to imagine that the grander questions about biology, religion, the humanities and evolutionary theory generally have been put to death.

The achievements on their list include new fields like epigenetics, the science of how genes are turned on or off to influence our bodies, and advances in cognitive and social sciences that yield ever more detailed empirical research into how we behave.

Waiting in the wings are new technologies such as genome editing, which can modify human genes to repair, enhance or customize human beings. Scientists in China are believed to have already genetically modified human embryos and the first known attemptto do so in the United States was reported this week (July 26).

Schaefer compared todays deeper understanding of biology to the higher resolution that photographers enjoy now that photography has advanced from film to digital images.

Genes once thought to be fairly mechanical in influencing human development leading to the my genes made me do it kind of thinking have been found to be part of complex systems that can act in response to a persons environment.

The Radcliffe Camera, a reading room of the nearby Bodleian Library, at University of Oxford on July 22, 2017. The unique building originally housed the Radcliffe Science Library. All Souls College is in the background. (Credit: RNS photo by Tom Heneghan.)

Since scientists succeeded in sequencing the genome in the late 1990s, they have found that epigenetic markers that regulate patterns of gene expression can reflect outside influences on a body.

Even simpler living objects such as plants contain a complex internal genetic system that governs their growth according to information they receive from outside.

To theologians who see a new biology emerging, this knowledge points to a more holistic system than scientists have traditionally seen, one more open to some divine inspiration for life.

In this view, the fact that epigenetic markers can bring outside pressures to bear on the genome deep inside a human means genetics is not a closed system, but part of the wider sweep of nature in which they, as religious thinkers, also see Gods hand.

Professor Alister McGrath, director of the Ian Ramsey Centre for Science and Religion. (Credit: Photo courtesy of University of Oxford.)

Nature is so complex and rich and that prompts questions about why on earth is this the case? If youre an atheist, how do you explain a universe that seems to have the capacity to produce these things in the first place? asked Alister McGrath, an Oxford theologian who is director of the Ian Ramsey Centre for Science and Religion that hosted the conference.

This in turn opened a space for theologians to augment the discussion about the new biology, he said.

Massimo Pigliucci, a philosopher at New Yorks City College with doctorates in genetics and evolutionary biology, also said scientism the idea that science can answer all lifes important questions was too limited.

Science informs and grounds certain philosophical positions; it doesnt determine them, he said. But the data cant settle ethical questions.

Pigliucci agrees with the trend to use the evolutionary paradigm to analyze fields outside of biology, including topics such as ethics and morality.

The life sciences tell us that the building blocks of what we call morality are actually found presumably they were selected for in nonhuman social primates, he said. Science gives you an account of what otherwise looks like magic: Why do we have a moral sense to begin with? How did we develop it?

Not all present agreed that science could explain religion.

Some suspect that biology has triggered some kind of devotion and there are too many people who practice this cult, said Lluis Oviedo, a theologian at the Pontifical University Antonianum in Rome.

His own research has found at least 75 books and academic articles trying to explain religion through evolution and he knew of about 20 more on the way, he said.

Although he thinks, the time of explaining through radical reduction is over, he admitted few biologists seemed ready to accept the more holistic new biology.

Even some scientists at the conference, while ready to engage with the philosophers and theologians, showed less interest in discussions about whether a new biology was emerging.

A dawn fog on Christ Church Meadow obscures the view of the historic University of Oxord in England. (Credit: Photo courtesy of Creative Commons/Tejvan Pettinger.)

Im pragmatic, explained Ottoline Leyser of the University of Cambridge, whose lecture on plant genetics was one of the conferences highlights.

Theologians in the decades long science and religion debate, which argues the two disciplines complement each other, have also become more pragmatic as their dialogue proceeds.

Oxfords McGrath said the theologians had become more modest in the claims they made about what religion could contribute to this debate. Unlike some more doctrinaire scientists, he said, they did not think they had all the answers.

They dont say These observations in nature prove or disprove God, he said. Our religious way of thinking gives you a framework which allows you to look at the scientific approach to the world and understand why it makes sense, but at the same time also to understand its limits.

Those things need to be in the picture if were going to lead meaningful lives.

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Scientists, theologians ponder if biology and religion go together - Crux: Covering all things Catholic

Govt says GM Mustard safe for humans, activists disagree – Hindustan Times

The Supreme Court is hearing the case concerning GMMustard Monday, even as the Centre told the court that GMcrops has no harmful effects on other crops and historically has proven safe for human consumption.

The environment ministry said that it has not made any decision regarding the commercial release of GMMustard, which could become the first genetically modified food crop allowed in India.

The Supreme Court could pass an injunction on the commercial release of the crop, even as it decides on a petition filed Aruna Rodrigues seeking a moratorium on the release of GMMustard.

The variety was cleared by the Genetic Engineering Appraisal Committee, Indias apex biosafety regulator that functions under the environment ministry, on May 11 and has since spurred a an avalanche of protests from environmental activists and farmer groups, who fear it would increase their dependency on multinational companies that develop these technologies.

In this case,one of the governments biggest claims is that it is developed indigenously at the University of Delhi, under the guidance of Prof Deepak Pental, a geneticist.However, groups like those led byVandana Shiva, disagree saying that the base patents for the new variety are owned by BayerAG, an agro major that is in the process of merging with Monsanto, another agro giant, which would further skew the agricultural technology market.

The Anti-GMlobby has approached Prime Minister Modi to obtain a moratorium on the release. The last time, a food crop went to this extent, was in the case of BTBrinjal, which also received the approval of GEAC but its release was stayed indefinitely by then environment minister, JairamRamesh.

The GM-Free India coalition points to the farcical conditional approval in the case of Bt cotton. This is all the more unacceptable in the case of GM mustard since this GM is completely unneeded in the first instance... We write to urge you to ensure that this GM mustard application is rejected in toto, the coalition said in a letter to the prime minister.

GEAC chairman, Amita Prasad, told the HindustanTimes that the approval granted by the committee was conditional not absolute and subject to certain conditions regarding area cropped, submission of regular reports.

With PTI inputs

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Govt says GM Mustard safe for humans, activists disagree - Hindustan Times

Editing human embryos with CRISPR is moving ahead now’s the time to work out the ethics – Phys.Org

Theres still a way to go from editing single-cell embryos to a full-term designer baby. Credit: ZEISS Microscopy, CC BY-SA

The announcement by researchers in Portland, Oregon that they've successfully modified the genetic material of a human embryo took some people by surprise.

With headlines referring to "groundbreaking" research and "designer babies," you might wonder what the scientists actually accomplished. This was a big step forward, but hardly unexpected. As this kind of work proceeds, it continues to raise questions about ethical issues and how we should we react.

What did researchers actually do?

For a number of years now we have had the ability to alter genetic material in a cell, using a technique called CRISPR.

The DNA that makes up our genome comprises long sequences of base pairs, each base indicated by one of four letters. These letters form a genetic alphabet, and the "words" or "sentences" created from a particular order of letters are the genes that determine our characteristics.

Sometimes words can be "misspelled" or sentences slightly garbled, resulting in a disease or disorder. Genetic engineering is designed to correct those mistakes. CRISPR is a tool that enables scientists to target a specific area of a gene, working like the search-and-replace function in Microsoft Word, to remove a section and insert the "correct" sequence.

In the last decade, CRISPR has been the primary tool for those seeking to modify genes human and otherwise. Among other things, it has been used in experiments to make mosquitoes resistant to malaria, genetically modify plants to be resistant to disease, explore the possibility of engineered pets and livestock, and potentially treat some human diseases (including HIV, hemophilia and leukemia).

Up until recently, the focus in humans has been on changing the cells of a single individual, and not changing eggs, sperm and early embryos what are called the "germline" cells that pass traits along to offspring. The theory is that focusing on non-germline cells would limit any unexpected long-term impact of genetic changes on descendants. At the same time, this limitation means that we would have to use the technique in every generation, which affects its potential therapeutic benefit.

Earlier this year, an international committee convened by the National Academy of Sciences issued a report that, while highlighting the concerns with human germline genetic engineering, laid out a series of safeguards and recommended oversight. The report was widely regarded as opening the door to embryo-editing research.

That is exactly what happened in Oregon. Although this is the first study reported in the United States, similar research has been conducted in China. This new study, however, apparently avoided previous errors we've seen with CRISPR such as changes in other, untargeted parts of the genome, or the desired change not occurring in all cells. Both of these problems had made scientists wary of using CRISPR to make changes in embryos that might eventually be used in a human pregnancy. Evidence of more successful (and thus safer) CRISPR use may lead to additional studies involving human embryos.

What didn't happen in Oregon?

First, this study did not entail the creation of "designer babies," despite some news headlines. The research involved only early stage embryos, outside the womb, none of which was allowed to develop beyond a few days.

In fact, there are a number of existing limits both policy-based and scientific that will create barriers to implanting an edited embryo to achieve the birth of a child. There is a federal ban on funding gene editing research in embryos; in some states, there are also total bans on embryo research, regardless of how funded. In addition, the implantation of an edited human embryos would be regulated under the federal human research regulations, the Food, Drug and Cosmetic Act and potentially the federal rules regarding clinical laboratory testing.

Beyond the regulatory barriers, we are a long way from having the scientific knowledge necessary to design our children. While the Oregon experiment focused on a single gene correction to inherited diseases, there are few human traits that are controlled by one gene. Anything that involves multiple genes or a gene/environment interaction will be less amenable to this type of engineering. Most characteristics we might be interested in designing such as intelligence, personality, athletic or artistic or musical ability are much more complex.

Second, while this is a significant step forward in the science regarding the use of the CRISPR technique, it is only one step. There is a long way to go between this and a cure for various disease and disorders. This is not to say that there aren't concerns. But we have some time to consider the issues before the use of the technique becomes a mainstream medical practice.

So what should we be concerned about?

Taking into account the cautions above, we do need to decide when and how we should use this technique.

Should there be limits on the types of things you can edit in an embryo? If so, what should they entail? These questions also involve deciding who gets to set the limits and control access to the technology.

We may also be concerned about who gets to control the subsequent research using this technology. Should there be state or federal oversight? Keep in mind that we cannot control what happens in other countries. Even in this country it can be difficult to craft guidelines that restrict only the research someone finds objectionable, while allowing other important research to continue. Additionally, the use of assisted reproductive technologies (IVF, for example) is largely unregulated in the U.S., and the decision to put in place restrictions will certainly raise objections from both potential parents and IVF providers.

Moreover, there are important questions about cost and access. Right now most assisted reproductive technologies are available only to higher-income individuals. A handful of states mandate infertility treatment coverage, but it is very limited. How should we regulate access to embryo editing for serious diseases? We are in the midst of a widespread debate about health care, access and cost. If it becomes established and safe, should this technique be part of a basic package of health care services when used to help create a child who does not suffer from a specific genetic problem? What about editing for nonhealth issues or less serious problems are there fairness concerns if only people with sufficient wealth can access?

So far the promise of genetic engineering for disease eradication has not lived up to its hype. Nor have many other milestones, like the 1996 cloning of Dolly the sheep, resulted in the feared apocalypse. The announcement of the Oregon study is only the next step in a long line of research. Nonetheless, it is sure to bring many of the issues about embryos, stem cell research, genetic engineering and reproductive technologies back into the spotlight. Now is the time to figure out how we want to see this gene-editing path unfold.

Explore further: In US first, scientists edit genes of human embryos (Update)

This article was originally published on The Conversation. Read the original article.

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Editing human embryos with CRISPR is moving ahead now's the time to work out the ethics - Phys.Org

Koch Institute’s Marble Center for Cancer Nanomedicine Brings Together Renowned Faculty to Combat Cancer – AZoNano

Written by AZoNanoJul 10 2017

The Koch Institute for Integrative Cancer Research at MIT will soon be reaching the first anniversary of the launch of the Marble Center for Cancer Nanomedicine, founded through a generous gift from Kathy and Curt Marble 63.

The Marble Center for Cancer Nanomedicines faculty is made up of Koch Institute members who are committed to fighting cancer with nanomedicine through research, education, and collaboration. Top row (l-r) Sangeeta Bhatia, director; Daniel Anderson; and Angela Belcher. Bottom row: Paula Hammond; Darrell Irvine; and Robert Langer. (Photo: Koch Institute Marble Center for Cancer Nanomedicine)

Bringing together leading Koch Institute faculty members and their teams, the Marble Center for Cancer Nanomedicine focuses on huge challenges in cancer detection, treatment and monitoring that can profit from the latest physics and biology of the nanoscale.

These challenges include spotting cancer earlier than present techniques allow, harnessing the immune system to combat cancer even as it progresses, using therapeutic insights from cancer biology to design therapies for formerly undruggable targets, integrating current drugs for synergistic action, and developing tools for more accurate diagnosis and improved surgical intervention.

Koch Institute member Sangeeta N. Bhatia, the John J. and Dorothy Wilson, Professor of Health Sciences and Technology and Electrical Engineering and Computer Science, serves as the Inaugural Director of the center.

A major goal for research at the Marble Center is to leverage the collaborative culture at the Koch Institute to use nanotechnology to improve cancer diagnosis and care in patients around the world.

Sangeeta N. Bhatia, Koch Institute Member

Transforming nanomedicine

The Marble Center joins MITs larger efforts at the forefront of discovery and advancement to solve the critical global challenge that is cancer. The concept of convergence the combination of the life and physical sciences with engineering is a trademark of MIT, the founding principle of the Koch Institute, and at the heart of the Marble Centers mission.

The center galvanizes the MIT cancer research community in efforts to use nanomedicine as a translational platform for cancer care. Its transformative by applying these emerging technologies to push the boundaries of cancer detection, treatment, and monitoring and translational by promoting their development and application in the clinic.

Tyler Jacks, Director of the Koch Institute and a David H. Koch Professor of Biology

The centers faculty six renowned MIT Professors and Koch Institute Members are committed to combating cancer with nanomedicine through research, education and partnership. They are, Sangeeta Bhatia (director), the John J. and Dorothy Wilson Professor of Health Sciences and Technology and Electrical Engineering and Computer Science; Daniel G. Anderson, the Samuel A. Goldblith Professor of Applied Biology in the Department of Chemical Engineering and the Institute for Medical Engineering and Science; Angela M. Belcher, the James Mason Crafts Professor in the departments of Biological Engineering and Materials Science and Engineering; Paula T. Hammond, the David H. Koch Professor of Engineering and head of the Department of Chemical Engineering; Darrell J. Irvine, Professor in the departments of Biological Engineering and Materials Science and Engineering; and Robert S. Langer, the David H. Koch Institute Professor.

Extending their partnership within the walls of the Institute, members of the Marble Center profit greatly from the support of the Peterson (1957) Nanotechnology Materials Core Facility in the Koch Institutes Robert A. Swanson (1969) Biotechnology Center. The Peterson Facilitys array of technological resources and know-how is unparalleled in the United States, and gives members of the center and of the Koch Institute, a distinctive advantage in the development and application of materials and technologies at the nanoscale.

Looking ahead

The Marble Center made the most of its first year, and has provided backing for advanced research projects including theranostic nanoparticles that can both detect and treat cancers, real-time imaging of interactions between cancer and immune cells to properly understand reaction to cancer immunotherapies, and delivery technologies for a number of powerful RNA-based therapeutics capable of engaging specific cancer targets with precision.

As part of its efforts to help adopt a multifaceted science and engineering research force, the center has offered fellowship support for trainees as well as valuable opportunities for scientific exchange, mentorship and professional development.

Promoting wider engagement, the Marble Center serves as a bridge to a broad network of nanomedicine resources, linking its members to MIT.nano, other Nanotechnology Researchers, and Clinical Partners across Boston and beyond. The center has also set up a scientific advisory board, whose members come from leading clinical and academic centers around the country, and will assist in shaping the centers future programs and continued development.

As the Marble Center enters another year of partnerships and innovation, there is a new landmark in sight for 2018. Nanomedicine has been chosen as the main theme for the Koch Institutes 17th Annual Cancer Research Symposium. The event is scheduled for June 15th, 2018, and will bring together national domain experts, providing a perfect forum for Marble Center members to share the discoveries and progresses made during its sophomore year.

Having next years KI Annual Symposium dedicated to nanomedicine will be a wonderful way to further expose the cancer research community to the power of doing science at the nanoscale. The interdisciplinary approach has the power to accelerate new ideas at this exciting interface of nanotechnology and medicine.

Sangeeta N. Bhatia, Koch Institute Member

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Koch Institute's Marble Center for Cancer Nanomedicine Brings Together Renowned Faculty to Combat Cancer - AZoNano

Nanomedicine opens door to precision medicine for brain tumors – Phys.Org

Killer T cells surround a cancer cell. Credit: NIH

Early phase Northwestern Medicine research has demonstrated a potential new therapeutic strategy for treating deadly glioblastoma brain tumors.

The strategy involves using lipid polymer based nanoparticles to deliver molecules to the tumors, where the molecules shut down key cancer drivers called brain tumor initiating cells (BTICs).

"BTICs are malignant brain tumor populations that underlie the therapy resistance, recurrence and unstoppable invasion commonly encountered by glioblastoma patients after the standard treatment regimen of surgical resection, radiation and chemotherapy," explained the study's first author, Dr. Dou Yu, research assistant professor of neurological surgery at Northwestern University Feinberg School of Medicine.

The findings were published in the journal Proceedings of the National Academy of Sciences.

Using mouse models of brain tumors implanted with BTICs derived from human patients, the scientists injected nanoparticles containing small interfering RNA (siRNA)short sequences of RNA molecules that reduce the expression of specific cancer promoting proteinsdirectly into the tumor. In the new study, the strategy stopped tumor growth and extended survival when the therapy was administered continuously through an implanted drug infusion pump.

"This major progress, although still at a conceptual stage, underscores a new direction in the pursuit of a cure for one of the most devastating medical conditions known to mankind," said Yu, who collaborated on the research with principal investigator Dr. Maciej Lesniak, Michael J. Marchese Professor of Neurosurgery and chair of neurological surgery.

Glioblastoma is particularly difficult to treat because its genetic makeup varies from patient to patient. This new therapeutic approach would make it possible to deliver siRNAs to target multiple cancer-causing gene products simultaneously in a particular patient's tumor.

In this study, the scientists tested siRNAs that target four transcription factors highly expressed in many glioblastoma tissuesbut not all. The therapy worked against classes of glioblastoma BTICs with high levels of those transcription factors, while other classes of the cancer did not respond.

"This paints a picture for personalized glioblastoma therapy regimens based on tumor profiling," Yu said. "Customized nanomedicine could target the unique genetic signatures in any specific patient and potentially lead to greater therapeutic benefits."

The strategy could also apply to other medical conditions related to the central nervous systemnot just brain tumors.

"Degenerative neurological diseases or even psychiatric conditions could potentially be the therapeutic candidates for this multiplexed delivery platform," Yu said.

Before scientists can translate this proof-of-concept research to humans, they will need to continue refining the nanomedicine platform and evaluating its long-term safety. Still, the findings from this new research provide insight for further investigation.

"Nanomedicine provides a unique opportunity to advance a therapeutic strategy for a disease without a cure. By effectively targeting brain tumor initiating stem cells responsible for cancer recurrence, this approach opens up novel translational approaches to malignant brain cancer," Lesniak summed up.

Explore further: Cold virus, stem cells tested to destroy deadly brain cancer

More information: Dou Yu et al, Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression, Proceedings of the National Academy of Sciences (2017). DOI: 10.1073/pnas.1701911114

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Nanomedicine opens door to precision medicine for brain tumors - Phys.Org

Precision NanoSystems to Host Nanomedicines Symposium – Technology Networks

Join Precision NanoSystems for its second annual nanomedicines symposium, entitled Nanomedicines: enabling new therapeutic modalities, on the 15th of July in Boston, MA. Following the success of last years inaugural event, the symposium will bring together distinguished researchers and drug developers from across the nanomedicines industry, and will precede the Controlled Release Societys Annual Meeting and Exposition from the 16th to 18th of July.

The symposium schedule has been designed to provide an overview of the latest developments in nanomedicine research, including strategies for overcoming in vitro and in vivo barriers to effective and targeted drug delivery. It will cover a diverse range of applications, with the keynote address To target or not to target: lessons from RNAi-based targeted lipid nanoparticles being provided by Professor Dan Peer from the Department of Cell Research and Immunology at Tel Aviv University. Other topics covered during the symposium will explore cutting-edge research in the fields of gene therapy, genetic vaccines and small molecule delivery. This will include industry talks from GSK, CureVac and Genentech, as well as presentations from the Beth Israel Deaconess Medical Centre, the University of British Columbia and Houston Methodist/Weill Cornell Medical College.

The symposium will also give attendees a chance to explore the latest enabling technologies in the nanomedicines sector with presentations from Precision NanoSystems and event sponsors Spectradyne, SpectrumLabs, Malvern Instruments and Sigma-Aldrich as well as providing networking opportunities throughout the day.

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Precision NanoSystems to Host Nanomedicines Symposium - Technology Networks

Why Kaiser added tech execs to its med school board – San Francisco Business Times


San Francisco Business Times
Why Kaiser added tech execs to its med school board
San Francisco Business Times
The roster includes Kaiser medical executives and Silicon Valley technology leaders, including Anne Wojcicki, CEO of 23andMe, and Mary Hentges, former chief financial officer of PayPal and CBS Interactive. Dr. Holly J. Humphrey, dean for medical ...

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Why Kaiser added tech execs to its med school board - San Francisco Business Times

Lions have what it takes to claim immortality against All Blacks – Irish Times

How to quantify this one? Rugbys greatest series, to quote Sky Sport NZs advertising campaign and that hyperbole doesnt seem excessive has reached its first series-deciding showdown since 1993. Viewed in that light, its possibly the biggest game of the professional era outside of World Cups.

For the back-to-back world champions, its an opportunity for a somewhat remodelled, younger team, captained by Kieran Read in his 100th test, and marshalled by the world player of the year, Beauden Barrett, and his brothers, to emulate illustrious names of the All Blacks past in the post-Richie McCaw and Dan Carter era and cement their own status.

For the Lions its an even rarer chance to grasp a slice of rugby-playing immortality, and emulate something only one Lions squad has ever achieved before. Then it was the sepia-tinged class of Willie John, Gibson, an array of Welsh legends and others, back in 1971.

Thats all then. Truly, its a once-in-a-lifetime opportunity, never to be experienced again.

The very nature of the tour and the series so far has set up the climax perfectly. The Lions were largely written off before this suicidal tour and from the outset. Gradually the quality of their players was honed into two strong teams, albeit one stronger than the other.

Even then, in the first test, they left opportunities behind, whereas the All Blacks clinically took theirs, whereupon the Lions defied expectations as 5/1 outsiders a week ago with a drama-filled comeback, admittedly against 14 men for 45 of the last 55 minutes on a raucous night in a rain-sodden Westpac Stadium. They were the clinical ones, with two nicely created and strongly finished tries. The Red Army were in raptures and are liable to be buttressed by further re-enforcements here. The All Blacks fans have been provoked into finding their voice. Another filthy forecast will only add to the drama.

Whod have thought, at the outset, that coming into this climactic third test, the Lions would not only have the momentum, but would have an unchanged side in a test for the first time since 1993? And meanwhile, that the All Blacks would be making three changes in personnel, including a 20-year-old (Jordan Barrett) and 24-year-old (Ngani Laumpape) making their first test starts in an untried back three and new midfield?

Revenge is a powerful spur in rugby, not least when the matches come close together. Wounded pride, and a whiff of cordite and all that, and therell plenty in the Auckland air. The Lions had it last week, the All Blacks this, and Ireland felt the full, brutal force of this blacklash in November.

Yet Warren Gatland is adamant, as is Johnny Sexton, that this Lions team can be even better again.

We also still dont think were at our best, we still think we can improve. Obviously theres going to be an improvement in the All Blacks but its something we dont think is going to be a shock to us. Rory Best spoke earlier in the week about how the Irish felt they didnt handle the physicality that the All Blacks brought in the game two weeks after the Chicago game, even though theyd spoken about it. Were ready for it.

I think theyre going to try to dominate us up front, particularly in the tight five, and try and give some of their inexperienced backs some go-forward. If they dont get that advantage up front and were aware of making sure we try and negate the threat of their tight five it should make the game interesting.

Despite their Queenstown time-out, and satisfaction from last week, theres no sense that the Lions players are content with their lot, according to Gatland.

I havent witnessed that. I hope I dont see it on Saturday night because that would be pretty disappointing. Theres a group of players there who are incredibly competitive and realise this is a massive opportunity to win a series in NZ. It doesnt come round very often. These Irish players who played in Chicago know what it was like two weeks later; theyve another chance to make sure they dont get caught with their pants down.

As in the previous two tests, the lines in the sand are liable to again be drawn close in along the gain line. The All Blacks won the collisions in round one, the Lions with some tampering in personnel in round two. The personnel now largely remains the same, with Laumape on from the start after being the All Blacks most potent runner, but also their weakest defender, a week ago.

Sean OBriens availability is a game changer, or at any rate his nonavailability would have been. If the Lions can reproduce the same strength and accuracy in the tackle close in, and if OBrien, Sam Warburton and co can slow down the All Blacks customary high-tempo game in other words, if they can stifle Beauden Barrett, they have every chance.

With yet more biblical rain forecast, the scrums could be a significant factor, as again will the referee, in this instance Romain Poite. He showed in the series decider four years ago that, as ever, he is both a strong, thick-skinned personality and favours the scrum going forward, whatever the means. The All Blacks will assuredly go after the Lions at scrum time.

The Lions have lost the penalty count by a combined 24-15 in the tests to date, and Gatland clearly feels the Lions havent been given a fair deal yet, and particularly in this series. He will meet with Poite, his assistants Jerome Garces and the hitherto unsatisfactory Jaco Peyper, a description that could also apply to the TMO George Ayoub.

All Gatland wants is that they have an open mind.

Thats the message I will hopefully give to the officials tomorrow night when I meet them. Weve got the confidence and self-belief to win this Saturday and win the series, so all we ask of them is to be open-minded, not to be surprised by us being in front and good enough to win. Thats an important message I am trying to deliver. I am not questioning their integrity or anything. Its just that sometimes its a mindset. The message is just, if there are some 50-50 calls, to be open-minded.

To support Gatlands theory that there is more in this team, the Sexton-Farrell combo was at the heartbeat of the two tries that turned the game on its head and has given the lie to Warrenball while giving them a cutting edge, which has been sharpened by a brand-new back three who have only played two games together. They also have a core of proven Lions. They wont be fazed.

The All Blacks havent lost at Eden Park since France won 23-20 in 1994, and have won 37 tests in a row there. They are hot favourites, and could win well, but if opportunity knocks, these Lions have tries in them.

After all the verbal sparring up until this point a week ago, both Gatland and Steve Hansen assumed a more restrained, balanced mindset, culminating in them both being quite philosophical on Thursday. Indeed, both had the exact same choice of wordswhen maintaining this game will not define these players.

Nor should it. They all have or will achieve plenty more.

Nevertheless, immortality beckons, and all that.

NEW ZEALAND: Jordan Barrett (Hurricanes); Israel Dagg (Crusaders), Anton Lienert-Brown (Chiefs), Ngane Laumape (Hurricanes), Julien Savea (Hurricanes); Beauden Barrett (Hurricanes), Aaron Smith (Highlanders); Joe Moody (Crusaders), Codie Taylor (Crusaders), Owen Franks (Crusaders), Brodie Retallick (Chiefs) Samuel Whitelock (Crusaders), Jerome Kaino (Blues), Sam Cane (Chiefs), Kieran Read (Crusaders, captain).

Replacements: Nathan Harris (Chiefs), Wyatt Crockett (Crusaders),

Charlie Faumuina (Blues), Scott Barrett (Crusaders), Ardie Savea (Hurricanes), TJ Perenara (Hurricanes), Aaron Cruden (Chiefs) or Lima Sopoaga (Highalnders), Malakai Fekitoa (Highlanders).

BRITISH AND IRISH LIONS: Liam Williams (Scarlets, Wales); Anthony Watson (Bath Rugby, England), Jonathan Davies (Scarlets, Wales), Owen Farrell (Saracens, England), Elliot Daly (Wasps, England); Johnny Sexton (Leinster, Ireland), Conor Murray (Munster, Ireland); Mako Vunipola (Saracens, England,) Jamie George (Saracens, England), Tadhg Furlong (Leinster, Ireland), Maro Itoje (Saracens, England), Alun Wyn Jones (Ospreys, Wales), Sam Warburton (Cardiff Blues, Wales, capt), Sean OBrien (Leinster, Ireland), Taulupe Faletau (Bath Rugby, Wales).

Replacements: Ken Owens (Scarlets, Wales), Jack McGrath (Leinster, Ireland), Kyle Sinckler (Harlequins, England), Courtney Lawes (Northampton, England), CJ Stander (Munster, Ireland), Rhys Webb (Ospreys, Wales), Ben Teo (Worcester Warriors, England), Jack Nowell (Exeter, England).

Referee: Romain Poite (France).

Previous meetings: Played 40. New Zealand 30 wins, 3 draws, Lions 7 wins.

Betting (Paddy Powers): 2/7 New Zealand, 22/1 Draw, 7/2 Lions. Handicap betting (Lions +11 pts): evens New Zealand, 19/1 draw, evens Lions.

Forecast: The Lions to win.

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Lions have what it takes to claim immortality against All Blacks - Irish Times

20 years after ‘Contact’ came out, the rest of pop culture still hasn’t caught up – Washington Post

We all have our own gatewayformative blockbuster. For me, first contact came during the hot summer of 1997 when a summer-camp trip to the movies sent me down a wormhole with Jodie Foster. Contact, Robert Zemeckiss sprawling, melancholy movie about Ellie Arroway (Foster), the scientist who first detects a signal from another world, may not be a box-office champ or a pure classic. But the movie, which came out 20 years ago today, set a marker for what smart, emotionally compelling science fiction can look like. And thinkingback on it as a professional critic, I see that Contact is one of the Rosetta stones that helps me understand why I love what I love today.

In Contact, Ellie (played as a little girl by Jena Malone) grows up with a father who teaches her to monitor shortwave radio frequencies and nurtures her love of the stars before dying, leaving her an orphan at age 9. As an adult, she becomes a talented scientist whose peers believe she is wasting her time and energy on the search for extraterrestrial intelligence. But after she receives funding from a reclusive billionaire (John Hurt), Ellie discovers unambiguous evidence that someone is out there, and decodes the message they have sent, which turns out to be schematics for a mysterious machine.

Unlike in most movies about contact with aliens, the extraterrestrials inContact are almost peripheral. Its the conflicts between humans that matter.

Ellies opponents are people like David Drumlin (Tom Skerritt), who favors applied science and pulls her funding in an effort to push her onto what he sees as an appropriate career path; national security adviser Michael Kitz (James Woods), who wants to militarize the work on Ellies discovery; and Richard Rank (Rob Lowe, weaponizing his handsomeness), the leader of a Christian Coalition-type organization who tries to stymie Ellies work on the grounds that aliens might not share human morality. The things that divide them are not how seriously they take an obvious alien threat, the tension in so many first-contact movies, but what counts as a worthy goal in science, who should control major advances and once the machine turns out to be a transport who should represent humanity to the stars. The big explosion, when it comes, is not the result of an alien attack, but a suicide bomber who believes we should stay here on Earth.

Its not so much the hard science fiction in Contact that has stayed with me as the films sense of whats important. Whats most realistic and compelling about the movie is its understated curiosity about how humanity would respond to a discovery of this magnitude. Contact, like Kim Stanley Robinsons Mars trilogy, is a sharp argument that by skipping to the most dramatic, conflict-oriented outcome, pop culture is leaving dozens of promising stories on the table. There are more things in our arcane policy debates about heaven and Earth than are dreamt of in action filmmakers philosophy.

Ellie herself is a character type thatremains relatively rare: a brilliant scientist who is passionate, enthusiastic, occasionally girly. Contact is a movie that doesnt think female characters have to be only one thing.

While the characters in the movie sometimes punish Ellie for being emotional, Contact itself never does. Of course it makes sense that she would have strong reactions to the degradation of the scientific research she believes in, or to Drumlins tendency to run her down and then claim credit for her work. Her alternately quavering and furious response to the panel that has convened to select the first passenger to another part of the universe doesnt demonstrate weakness. Instead, Ellies response reveals the hypocrisy of Palmer Joss (Matthew McConaughey), who exposes her agnosticism because he wants to keep her safe on Earth, and the scheming of Drumlin, who fakes a piety he doesnt really feel to outflank her. Fosters limpid eyes and quivering chin are some of Contacts best special effects.

In keeping with that confident approach to emotion, Contact isnt afraid to be a sweeping romance in whichbig ideas fuel chemistry. Ellie and Palmers meet-cute involves his research on the impact of technology on indigenous communities; the first thing that attracts her to him, beyond McConaugheys laconic charm, is Palmers defense of pure rather than merely applied science. Ideas, particularly Palmers conviction that aliens first contact should be with someone who believes in God, keep them apart for much of the movie, which is realistic: Ellie would be hopelessly compromised if she threw over her lifes work for the theologian who blocks her from her dearest ambition, even if he is drawling and cute. Palmers big romantic gesture is to show up and supportEllie when she gets the opportunity to be the one to make first contact after Drumlin is killed in a terrorist attack. Intellectual arguments dont substitute for sexual heat in Contact theyare the heat.

Fosters performance as Ellie isnt aggressive or extravagant; it doesnt loom over the movies that have followed it.But I think of her every time I watch Amelia Brand (Anne Hathaway) head off into the abyss to try to save humanity in Interstellar, or Ryan Stone (Sandra Bullock) struggle to save herself in Gravity. Ellies cerebral, optimistic quest to prove we arent alone in the universe is a counterpoint to Ellen Ripleys (Sigourney Weaver) ferocious battle for survival in the Alien franchise, an argument that in space, no one can hear you scream, but someone just might introduce you to the greatest secrets of the universe.

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20 years after 'Contact' came out, the rest of pop culture still hasn't caught up - Washington Post

The Most Catholic of Catholic Families – Commonweal

A danger of having a priest for a dad: he just might write a homily about you. At nineteen, shortly after running away with a man she met on an online poetry forum, Patricia Lockwood found herself sitting in church one Sunday, listening to her dad preach a homily titled The Prodigal Daughter.

Lockwood took it in stride. At the time my reaction alternated between embarrassment and amusement, but now I see it must have been prophetic, she writes in her memoir, Priestdaddy. All these years I have been tending the pigs of liberalism, agnosticism, poetry, fornication, cussing, salad-eating, and wanting to visit Europe, but I am back home now, and the pigs can't come with me.

Twelve years after she first leaves the rectory, a series of misfortunes leaves Lockwood and her husband, Jason, jobless and broke. With nowhere else to go, the couple pack up their belongings and moves into the Kansas City rectory shared by Lockwoods mother, Karen, and her father Greg, a Roman Catholic priest.

Lockwoods situation is improbable in a lot of ways, the least of which is having a married Catholic priest for a father; as she puts it, the mercy of the church exists for me on this earth in an unusually patriarchal form. And although she never attended college, Lockwood has published poetry in The New Yorker and the London Review of Books, amassed over sixty-seven-thousand Twitter followers, and earned a significant cult following for her dark, subversive sense of humor.

Lockwood had previously published two books of poetry, Balloon Pop Outlaw Black and Motherland Fatherland Homelandsexuals, but living with her parents inspired her to try a new writing project: recording life with her irrepressible and quirky family. The result is Priestdaddy, a wry, observant, and funnyif ultimately unevenaccount of growing up in possibly the most Catholic of Catholic families.

Born in Fort Wayne, Indiana, Lockwood was raised in all the worst cities of the Midwest, moving each time her father was assigned to a new parish. In an interview with the New York Times Magazine, Lockwood recalls living in five different rectories and attending six different schools. Growing up, her life (unsurprisingly) revolved around the Catholic Church. She sang in a choir and attended a youth group called Gods Gang that was 40 percent shag carpet and 60 percent Bible verses.

After a whirlwind internet courtship, Lockwoods husband Jason proposed to her in the parking lot of a Krogers grocery store (the most matrimonial of all grocery stores) the first time they met in person. They spent the next twelve years roaming the country while Jason worked as a newspaper editor and Lockwood wrote poetry. After she left home, Lockwood also quietly left the Catholic Church. It was like forgetting a language you spoke a long time ago, when you were a child, she says. During the eight months they live in her fathers rectory, Lockwood isthrown out of the bohemian, free-wheeling life she and Jason created for themselves and back into a world where dinner with the bishop is the social event of the month.

Lockwood is in a unique position to rediscover this world, and she generally does so with astuteness and a wicked sense of humor. She hasnt forgotten the language of her former homeland so much as turn[ed] it inside out, repurpose[ed] it, and occasionally use[d] it to tell jokes. Her poetry experiments with explicit sexual humor and religious imagery, but Priestdaddy is more concerned with rediscovering a world Lockwood chose to leave, and finding her new place in it. Back again in that world, Lockwood reexamines her upbringing, her family, and her former church. She treats her eight-month stay in the rectory as an anthropological mission of sorts, reexamining the terrain of her childhood. Everyone gets a window. This is what mine looks out at, she writes.

Priestdaddy jumps seamlessly back and forth between past and present. Memories from the authors Midwestern childhood are interrupted by sketches of daily life at the rectory: Karen reading about demonic rosaries on the internet or Greg playing his electric guitar with a tone-deaf enthusiasm that sounds like a whole band dying in a plane crash in 1972.

According to his daughter, Fr. Greg doesn't have a conversion story; he has an origin story, like Superman or Batman. This tells you everything you need to know about Greg Lockwood and his larger-than-life personality. Greg met Karen in high school, married at eighteen, and joined the Navy. Onboard the nuclear submarine the USS Flying Fish, he experienced what he calls the deepest conversion on record. His daughter attributes his conversion to the seventy-two times the crew watched The Exorcist over the course of the patrol. You're a drop of blood at the center of the ocean. All of a sudden you look up at a screen and see a possessed twelve-year-old with violent bedhead vomiting green chunks and backwards Latin, Lockwood writes. You would convert too, I guarantee it.

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The Most Catholic of Catholic Families - Commonweal

Face to faith – Open Democracy

It is better to be united in our ignorance than divided in our certainties.

Credit: Flickr/SteveRhodes. Some rights reserved.

From time to time stories appear in our newspapers of priests or ministersmaybe even a bishopwho have lost their faith. Such headlines are misleading and far too simplistic. It is not faith which is lost, but beliefs: by contrast, faith is transformed.

Beliefs can be naturally outgrown and discarded during our lives as we fulfill St Pauls eloquent prophecy: When I was a child I spoke as a child, I understood as a child, I thought as a child; but when I became a man I put away childish things.

Although this process ought to continue throughout life, for a priest or minister it is most comfortably achieved after one is retired. Working clergy may regard it as their duty to defend the system, to loyally justify the church, to be sensitive to the feelings of its people, and to take care not to destroy another persons faith.

But all of these things can make us more cautious than we would like to be. That is important, because spiritual growth and development must be continuous, even if that means leapingnot lapsinginto agnosticism, recognizing that there is much of mystery in life and that we do not know all the answers.

At the heart of this process we come to see Christianityalong with Judaism and Islammore as historical religions than simply faith-based; man-made rather than divinely created. As such, they have to be judged by the evidence of history, and their scriptures scrutinized just like any other historical document.

History may then indicate that all ancient religionsand maybe some modern creeds toohave arisen largely out of pre-scientific mythologies in which what is called the supernatural lies at the center. An essential aspect of growing up demands that we reject the idea of the supernatural and recognize that the natural is wonderful enough.

Few people can deny that Christianity has often been a form of blessing to many people, and that the church has sometimes been beneficial to the improvement of human society. In the realm of the arts, in music, painting and literature, religious belief has inspired incomparable beauty and innovation; and in human behavior, incredible heroism and self-sacrifice.

But there is a darker side which, in our growing, we increasingly come to see as outweighing the lighter on the scales of human judgment. Dogma has dominated reason. Superstitions have been encouraged as facts. Charity and love have been subordinated to inquisition and cruelty. Fear has governed where hope should have reigned. The wisdom and experience of half of humankindwomenhas been ignored and belittled.

A distorted picture has emerged and prevailed over the original teachings of the guru of Christianity: Jesus. Growing up entails re-evaluating the one who saw himself as the son of man, rather than the son of God.

In no area of life can this process of transformation be seen more clearly than in the realm of morality. So it is not surprising that this subject has come to the fore, and that the issues involved have received more attention in the 20th and 21st centuriesespecially in the aftermath of the Second World War during which human immorality was exposed in all its naked horror. It really did seem possible that after 1945 that humankind might come of age.

In the years that followed, the issue of sexuality in particular came to dominate both thought and practice. Liberation became the buzzword in theology, in personal and social relationships, in race relations and in national aspirations. Andif at times this led in destructive or uncomfortable directions for someso be it, for we have come to realize that it is better to be united in our ignorance than divided in our certainties.

That, surely, is a sign of maturity.

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Face to faith - Open Democracy

Trump's CDC Pick Peddled 'Anti-Aging' Medicine to Her Gynecologic Patients – New York Magazine

Brenda Fitzgerald. Photo: Branden Camp/AP

On first glance, the most startling thing about Donald Trumps pick to lead the Centers for Disease Control (CDC) and Prevention was its propriety: Brenda Fitzgerald is a trained obstetrician-gynecologist who worked for three decades in private practice before becoming Georgias public health commissioner in 2011. In her time in the post, Fitzgerald won the respect of her peers in other states, and they recently elected her president of the nonprofit group that represents Americas state and territorial public-health agencies. Her appointment was praised by Barack Obamas former CDC director Tom Frieden.

Fizgerald is a staunch believer in the mission of her agency, and has said that the private sector is incapable of performing its core functions. While she has longstanding ties to the Republican Party having twice run unsuccessfully for Congress she has proven willing to subordinate conservative orthodoxy to her convictions as a medical professional: In her first House run, Fitzgerald argued that decisions about abortion should be left to women and their doctors.

Finally, as the first female OB/GYN ever tapped to run the CDC, Fitzgerald brings a unique (and historically marginalized) perspective with her to the federal government.

All this makes her a bizarre addition to the Trump cabinet. Thus far, the president has evinced a deep commitment to stocking his administrations domestic agencies with appointees who are eithercomically unqualified for their assignments (Ben Carson), hostile to the very purpose of the department theyre meant to direct (Scott Pruitt, Betsy DeVos), or rich, white men who bring ethical baggage and/or flagrant conflicts of interest to their posts (Tom Price, Rex Tillerson, Wilbur Ross, Gary Cohn, etc.).

But fear not the fundamental laws of our political universe have not been rewritten. Once you read this dispatch from Forbess Rita Rubin, everything will fall back into place:

Dr. Brenda Fitzgerald, appointed Friday as director of the U.S. Centers for Disease Control and Prevention, is a board-certified obstetrician/gynecologist who saw patients for 30 years in private practice.

Unlike any OB/GYN I know, Fitzgerald treated men as well as women. Thats because besides being board-certified in obstetrics and gynecology, she is a fellow in anti-aging medicine.

Among her credentialslisted on [her gynecological practices] website: board certification in Anti-Aging and Regenerative Medicine by theAmerican Academy of Anti-Aging Medicine. However, the American Board of Medical Specialties, made up of the specialty boards that certify physicians,doesnt recognize the American Academy of Anti-Aging Medicine(A4M), which promotes the use of intravenous nutritional therapy, bioidentical hormone replacement therapy (BHRT) and pellet therapy, in which tiny pellets that contain hormones are placed under the skin.

[B]ioridiculous is how Dr. Nanette Santoro, chair of obstetrics and gynecology at the University of Colorado School of Medicine, described the use of bio-identical hormones in a recent guest post on the North American Menopause Societys MenoPause blog. Santoro described a patient whose hair had fallen out because she had been rubbing testosterone cream into her skin every day and overdosed. Another patient, age 52, had estrogen levels higher than when she was pregnant, due to estrogen pellets that had been inserted under her skin months earlier.

Now, a snake-oil saleswoman fits perfectly into the Trump cabinet. The president and secretary of Housing and Urban Development have both dabbled in peddling scientifically dubious supplements, while the secretary of Education owes her fortune to one of the most successful pyramid schemes in world history.

Fitzgerald wasnt shy about her antiaging expertise, touting that rsum item in her bio on the Georgia Department of Public Health website. Further, her private practices old homepage included the following frequently asked questions.

What is anti-aging medicine?

It is a new specialty of medicine that studies the changes that occur in all of us as we age. It is dedicated to treating the cause of problems, not just the symptoms.

How do I know I am taking the right supplements?

We can now measure the vitamins, antioxidants, necessary fats and proteins in your cells with a simple blood test. If you like the supplements you are taking (Juice Plus, for example), we can tell you what you need to add.

Can you treat my husband?

I have taken additional training in male hormones so that I may treat male hormone deficiencies as well as female deficiencies.

Why did you become interested in anti-aging medicine?

I got older! The life expectancy for women in 1900 was 48. The majority of women never reached the hormone depleted state of menopause just 100 years ago. Now most of us can expect to live half of our lives without natural optimal hormone production.

The Food and Drug Administration has warned that it has no evidence that the bio-identical hormones central to anti-aging medicine are safer or more effective than other hormone products.

All that said, even with her scientifically dubious side-hustle, Fitzgerald is still among the most defensible appointments Trump has made. Whatever her unorthodox views on the virtues of antiaging hormone therapy, she does have a significant body of experience in managing public health. It seems likely that the former will have more bearing on her capacity to combat the threat that Ebola, Zika, antibiotic-resistant bacteria, and other infectious diseases pose to the country and globe.

Which is to say: At least we arent relying on Ben Carson to coordinate the federal governments response to the next pandemic.

More concerning than Trumps appointment of Fitzgerald is his administrations proposal to cut the CDCs budget by $1.2 billion.

Heres hoping that bubonic plague doesnt emerge from melting Siberian ice anytime soon.

The money, included in a Homeland Security spending bill, is likely to set up a shutdown fight with Democrats.

The administration is already brainstorming how they can spin this into a conversation about Clintons mishandling of sensitive intelligence.

Will the extra time enable Republicans to come up with a health-care bill 50 senators support? Or deals on taxes and the budget?

Kushner attended a meeting that was explicitly framed as an opportunity to benefit from Russian meddling. And he still has a security clearance.

Weve gone from evidence of collusion to proof.

A man of many talents.

GOP base voters have long regarded the media as biased allies of their enemies. Its taken Trump to convince them any bad news is just made up.

This is obviously very high level and sensitive information but is part of Russia and its governments support for Mr. Trump.

The first rule of Tautology Club is the first rule of Tautology Club.

Protesters promised to greet him if he made his official state visit.

An unedited Q&A with the prominent climatologist, who took issue with New Yorks latest cover story for being overly doomist.

The Kremlin-linked lawyer who met with Donald Trump Jr. claims that he was desperate for dirt on Clinton but she had none to give.

Hua Haifeng was investigating factories where the First Daughters shoes we
re made before his arrest.

In their desire to see Trump banished, theyve embraced some unusual bedfellows, like Benjamin Wittes.

It involves a beauty pageant, a Russian pop star, and Trumps decades-old dream of building in Moscow.

Sources say before meeting with a Kremlin-connected lawyer, he was told the dirt she had on Hillary Clinton was part of a larger Russian effort.

The pro-Trump local-news giant has tripled the number of Boris Epshteyn segments that all its affiliates must air each week.

He could tap McConnells favorite Luther Strange or Hannitys favorite Mo Brooks. Theocrat Roy Moores in the mix, too.

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Trump's CDC Pick Peddled 'Anti-Aging' Medicine to Her Gynecologic Patients - New York Magazine

Vitals – Axios

Good morning ... The Senate is back in Washington this week after a weeklong recess, with a new goal of trying to pass a health care bill before the next recess in August.

What to expect this week: Everything in this process in constant flux, but for now, our colleague Caitlin Owens' sources aren't expecting to see an updated bill or CBO score this week. The Congressional Budget Office is still working through some of the policy options Majority Leader Mitch McConnell sent over before the break, and the two can exchange more information privately this week as long as the bill is still private, too.

The latest: CBO is taking a look at a handful of possible amendments, including Sen. Ted Cruz's proposal to let insurers sell policies that don't comply with the Affordable Care Act he's calling them "freedom plans" as long as they also sell plans that do comply with the law's coverage requirements.

The outlook: It certainly didn't get any sunnier over the recess.

Data: Kaiser Family Foundation; Graphic: Lazaro Gamio / Axios

Every time you hear the Trump administration or Congress fight about rising ACA premiums, or what will happen to people with pre-existing conditions, just remember we're talking about issues that affect 7% of the population. That's how many people are in the individual health insurance market, or the "non-group" market.

The graph above, put together by Axios' Lazaro Gamio with data from the Kaiser Family Foundation, shows what the rest of the population looks like including the much larger employer health insurance marketplace, Medicare, and Medicaid.

Why it matters: This shows how much time we're spending on a relatively small portion of the market. The ACA was supposed to fix the problems of the individual market, which was dysfunctional for anyone with the slightest health problem. In doing so, it created other problems, including rising premiums. But when you hear about those sky-high rate hikes because of "Obamacare," chances are, they're not your sky-high rate hikes unless you happen to be in that market.

Yes, but: The spending limits that have been proposed for Medicaid really do matter, and they affect a larger group 20% of the population. So every minute Washington spends on the smaller group is time that could have been spent talking about Medicaid changes that will affect more people.

There's another piece of Cruz's proposed change to the Senate health care bill that may be accepted more easily than his ideas on insurance deregulation. He wants to let people use health savings accounts to pay for their health insurance premiums. Conservatives have been pushing to expand HSAs, which allows people to set aside tax-free money to spend on certain health expenses.

Yes, but: Not all conservative health care wonks are impressed. Tom Miller of the American Enterprise Institute calls it a "symbolic move," and not the best way to achieve the conservative goal of equalizing the tax treatment between the individual market and employer-sponsored insurance. But Arnold said it would be more powerful in combination with other changes already in the bill, like increasing the annual contribution limits for HSAs.

Bob Herman has a deep look this morning at "upcoding" the practice where doctors and hospitals bill for more expensive services than they actually provide. The payment system gives them lots of incentives to do that, and numerous settlements between health care companies and the Department of Justice indicate it's a widespread problem.

Why it matters: Upcoding affects everyone it saps money from the taxpayer-funded Medicare and Medicaid programs and could lead to higher premiums for people with commercial insurance. But there's no evidence the health care system is fighting upcoding effectively, or that the problem will go away. More here.

Fun fact: No one forced Bob to include the name of one coding webinar: "Keeping up with the Code-ashians." He did that on his own. Send your complaints to him.

Cerner, one of the nation's leading providers of electronic health records, lost its CEO to cancer yesterday. The company announced that Neal Patterson, who co-founded the company, died from complications from a recurrence of the disease (the Kansas City Star identified it as a soft-tissue cancer). Cliff Illig, vice chairman of the board and another co-founder of the company, has been named chairman and interim CEO.

What we're watching this week: Are we really going to have to start hitting "refresh" on the CBO website again? Also, House Energy and Commerce health subcommittee hearing on medical product manufacturer communications, Wednesday; Employee Benefit Research Institute health policy forum, focusing on health savings accounts, Wednesday.

What else are you watching? Let us know: david@axios.com, baker@axios.com.

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Vitals - Axios

Mega NFC Medical10: Beauty- and Anti-Aging Laureate Celebrates Fifth Anniversary – Digital Journal

MEGA NFC medical10 is laureate of the 4th ANTI-AGING & BEAUTY TROPHY 2016/2017 and receives further development of its formula and technology

Hamburg, Germany - July 11, 2017 - (Newswire.com)

For years, MEGA NFC medical10, an exclusive German detox product, has been an established brand with the users of some the most expensive wellness clinics and spas in Europe. In the recent past, it has experienced a further development as a consequence of changes in management and an investment of an international holding. In the summer of 2015 NANOBLE HEALTH CONCEPT has acquired all patents and invested in the further development of the product. The improvements concern the origin of the raw material, which is from now on extracted from different pure sources all over the globe. By combining different clinoptilolites the products quality and purity could be further improved. At the same time, the patented manufacturing process HENA was further optimised so that a higher degree of activation could be achieved. In addition, calcium and magnesium carbonate was added to optimise the gastric pH value and to promote healthy muscle, nerve and bone metabolism. The product has also been adapted to the stricter requirements for medical devices, resulting in new fields of application for the users. As a result, MEGA NFC medical10 can be used to reduce histamine levels, support the intestinal wall and remove aluminum, cadmium, and cesium from the body.

MEGA NFC medical10 has celebrated its five-year anniversary with the brand new slogan Better life should last longer. Soon after it had been introduced for the first time in 2011, the product has become popular in numerous renowned clinics across Europe. Since then, it has been used on a regular basis for anti-aging and aesthetic medical purposes. MEGA NFC medical10 is a medical product produced and certified in Germany. It is made from natural clinoptilolite which is modified and activated by the worldwide patented HENA system (High Energy Natural Activation). As a result, the effective surface of the mineral is increased and its reactivity enhanced. The potential of this product has recently been recognized by the international congress AMEC 2016 in Paris (Aesthetic & Anti-aging Medicine European Congress): MEGA NFC medical10 was the laureate of the 4th ANTI-AGING & BEAUTY TROPHY 2016/2017.

What doctors particularly enjoy about our premium product are the consistent and convincing results, that can be achieved with such a simple application, explains CEO of NANOBLE HEALTH CONCEPT Alrich Kruse. What is more, MEGA NFC medical10 can be used effectively alongside other treatments and cosmetic procedures because it actually supports their effects." The bright grayish powder is dissolved in a glass of water and taken on an empty stomach. It is used in prestigious clinics like the SHA WELLNESS CLINIC and the BAD RAGAZ MEDICAL RESORT.

Being a leader and maintaining this position is a challenge that can only be met with a team of highly professional scientists, innovative manufacturing processes, integration of new technologies and continuous progress," says Alrich Kruse. Also in 2017, the company finally received the approval for the Russian market.

FOR MORE INFORMATION PLEASE CONTACT:

Mr. Alrich Kruse, CEO Tel: +49 40 808 093 140 Email: kruse@nanoble-germany.de http://www.meganfc.eu to find out more information

Press Release Service by Newswire.com

Original Source: Mega NFC Medical10: Beauty- and Anti-Aging Laureate Celebrates Fifth Anniversary

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Mega NFC Medical10: Beauty- and Anti-Aging Laureate Celebrates Fifth Anniversary - Digital Journal

Celebrating diversity – News24

IN general, the South African Constitution, as is clear from its preamble where reference to deity occurs, reflects a bias in favour of religion, as opposed to atheism and agnosticism. This bias in favour of religion is a departure from the pure principle of equality between believers and non-believers as set out in section nine.

In particular, section 15 of the Constitution provides that everyone has the right to freedom of conscience, religion, belief and opinion. It states further that religious observances may be conducted at state and state-aided institutions provided that:

those observances follow rules made by appropriate authorities;

they are conducted on an equitable basis; and

attendance at them is free and voluntary.

This provision obviously reflects a bias in favour of religion in general, unlike the position in the United States where religious exercises, such as prayers, are not permitted in the schools. In the U.S., the idea of neutrality does not even permit one minute of silence for meditation or voluntary prayer.

How section 15 is actually interpreted and applied in practice is a great challenge, particularly when there is a dominant religion, as is the position in South Africa,with the Christian religion.

So for instance, mandatory school prayers obviously constitute a violation of religious freedom, but even voluntary prayers could constitute a violation by putting pressure on children to participate. Also, is it practical to allow for religious observances for every religious faith, regardless of how large or small their representation in a school?

It is therefore the interpretation of the above provision of the Constitution, which is central to the recent landmark judgment of Judge Willem van der Linde in the South Gauteng High Court, in which he categorically ruled against the promotion of one religious denomination over any other at public schools by declaring that neither a school governing body nor a public school may lawfully hold that it subscribes to only a particular religion to the exclusion of others.

This seminal judgment was initiated in May by the Organisation for Religious Education and Democracy (Ogod), which brought an application to the high court seeking an order ruling against having a dominant religion observed in public schools.

It had profound reservations about the practices of scripture reading and singing of hymns in assembly, and the decoration of the walls of the school with Bible verses.

It was argued by the schools in question that as a result of religious freedom they are entitled to have an ethos or character, determined by their governing bodies, based on the community that feeds the schools with pupils. This reflects a conservative or fundamentalist Christian theological approach, as expressed by the Christian View Network, which did not approve of the ruling by Van der Linde. However, such an approach must inevitably lead to the domination of one religion over others.

Ogod brought the application against six Afrikaans state schools.

The gravamen of its argument was that the religious practices at these schools gave rise to the suppression of the scientific teaching of evolution, and a dogmatic religious ethos that in effect was a form of coercion and a gross abuse of the rights of pupils.

In his judgment, Van der Linde declared that public schools are indeed not rarefied but public ones that need to achieve universal and non-discriminatory access to education.

Referring to section 15 of the Constitution, the judge stated that provision for religious policies and observances must be conducted on a free, voluntary and equitable basis. As a result, he declared unequivocally that in this country, our diversity is celebrated, not tolerated.

He therefore questioned the acceptance by schools using rules laid down by the governing body, to hold out to be exclusively a single denomination, be it Christian, Muslim, Buddhist or atheist. What is clear from the judgment is that although religious observances and practices in schools are permissible, protecting children from coercion is essential. This allows broad-based religious education, rather than dogmatic instruction that promotes one religion over another.

It is therefore, according to Reverend Ian Booth, chairperson of Diakonia Council of Churches, not the responsibility of public schools to teach and instruct children in their respective faiths. This should be done in places of worship.

This is the viewpoint of a minister with a liberal Christian theology, in contrast with that expressed by the Christian View Network. In the pluralistic society that South Africa is, cultural and religious tolerance are essential for social cohesion.

This is necessary to protect our celebrated diversity. In this regard, Van Lindes judgment makes a fundamentally sound contribution to our jurisprudence, which has been widely welcomed by most religious commentators, who include leaders in the Hindu, Tamil, Muslim and Christian faiths.

George Devenish is an emeritus professor at UKZN and one of the scholars who assisted in drafting the Interim Constitution in 1993.

24.com encourages commentary submitted via MyNews24. Contributions of 200 words or more will be considered for publication.

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2 Studies Link Coffee To Longevity – CBS Minnesota / WCCO

2 Studies Link Coffee To Longevity

Either caffeinated or decaf is associated with a lower risk of death, Chris Martinez reports (1:50). WCCO 4 News At 5 July 10, 2017

Good Question: Why Has Pay For U.S. Workers Stayed Relatively Flat?New job numbers show our wages are growing at about 2.5 percent a year, below what economists consider typical in a healthy economy, Heather Brown reports (2:22). WCCO 4 News At 10 July 10, 2017

Stillwater Family Heals After Teens Death By Speaking Out About SuicideA Stillwater family believes it's time to fight back against the stigma and talk more about teen suicide -- before it's too late, Liz Collin reports (4:55). WCCO 4 News At 10 July 10, 2017

'If It Looks Good, Buy It': Amazon Prime Day Offers Deals For MembersPrime Day runs for 30 hours and features deals for Amazon Prime members, John Lauritsen reports (2:07). WCCO 4 News At 10 July 10, 2017

How Medical Marijuana Is Making A Difference For A Minn. FamilyA Twin Cities couple is counting down the days until their daughter can get life-changing medicine, Jeff Wagner reports (2:17). WCCO 4 News At 10 July 10, 2017

MPD Responds To Video Of Officer Shooting DogsThe shooting took place on Queen Avenue North on Saturday night and was caught by surveillance cameras, Reg Chapman reports (1:12). WCCO 4 News At 6 -- July 10, 2017

Its Gonna Be Weird: Stillwater Native On Competing In Minnesota X GamesFor many, the X Games are exciting, but for 19-year-old Nicole Hause, this competition is personal, Susan-Elizabeth Littlefield reports (2:27). WCCO 4 News At 6 July 10, 2017

How Medical Marijuana Is Making A Difference For A Minn. FamilyA Twin Cities couple is counting down the days until their daughter can get life-changing medicine, Jeff Wagner reports (2:17). WCCO 4 News At 10 July 10, 2017

2 Studies Link Coffee To LongevityEither caffeinated or decaf is associated with a lower risk of death, Chris Martinez reports (1:50). WCCO 4 News At 5 July 10, 2017

Looking Forward To The 15th Annual Red Ribbon RideGina Lemon and Amy Moser spoke with Ali Lucia about the bike ride at MOA that raises money for AIDS/HIV service organizations (2:57). WCCO 4 News At Noon July 10, 2017

Good Question: Why Has Pay For U.S. Workers Stayed Relatively Flat?New job numbers show our wages are growing at about 2.5 percent a year, below what economists consider typical in a healthy economy, Heather Brown reports (2:22). WCCO 4 News At 10 July 10, 2017

Stillwater Family Heals After Teens Death By Speaking Out About SuicideA Stillwater family believes it's time to fight back against the stigma and talk more about teen suicide -- before it's too late, Liz Collin reports (4:55). WCCO 4 News At 10 July 10, 2017

'If It Looks Good, Buy It': Amazon Prime Day Offers Deals For MembersPrime Day runs for 30 hours and features deals for Amazon Prime members, John Lauritsen reports (2:07). WCCO 4 News At 10 July 10, 2017

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Viagra jelly side effects – Kamagra viagra jelly reviews – Van Wert independent

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DELPHOS A Delphos couple were injured in a home invasion assault that occurred Saturday morning.

David and Dianna Allemeier of 209 S. Pierce St. in Delphos were both taken to St. Ritas Medical Center in Lima for treatment of injuries received when a man gained entry to their home and reportedly assaulted them.

Delphos Police were first called out at 6:05 a.m. Saturday on a report of a suspicious person in the 300 block of Jackson Street who was knocking on doors and then walking away. However, while en route to that call, officers were informed that a man had been injured and was bleeding in the 200 block of Pierce Street.

When officers arrived on the scene, they found Allemeier bleeding from an injury to his neck. The Delphos resident said he received the injury from a man who had gained entry into his home.

Officers approached the residence and found the back door unlocked and a lot of blood at the scene. The home was secured and a K-9 and Crime Scene Unit sought from the Allen County Sheriffs Office.

Allemeier then said his wife was still in the house and officers then entered and found Mrs. Allemeier, who was also injured, in the bedroom area of the residence.

After the Allemeiers were transported to the hospital, a K-9 search was made of the area, and the house was processed by an Allen County sheriffs deputy.

No information was released on whether items were taken from the Allemeier house.

Police are currently seeking a young, skinny white male with black hair, possibly wearing cutoff shorts. Anyone with information is asked to contact the Delphos Police Department or Allen County Sheriffs Office.

The investigation is continuing, with no further information forthcoming at this time.

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