IonQ and South Korea’s Q Center Announce Three-Year Quantum Alliance – PRNewswire

COLLEGE PARK, Md., Jan. 19, 2021 /PRNewswire/ --IonQ, the leader in quantum computing, today announced a three-year alliance with South Korea's Quantum Information Research Support Center, or Q Center. The Q Center is an independent organization at Sungkyunkwan University (SKKU) focused on the creation of a rich research ecosystem in the field of quantum information science. The partnership will make IonQ's trapped-ion quantum computers available for research and teaching across South Korea.

IonQ's systems have the potential to solve the world's most complex problems with the greatest accuracy. To date, the company's quantum computers have a proven track record of outperforming all other available quantum hardware.

Researchers and students across South Korea will be able to immediately start running jobs on IonQ's quantum computers. This partnership will enable researchers, scientists, and students to learn, develop, and deploy quantum applications on one of the world's leading quantum systems.

"I am proud to see IonQ enter this alliance with Q Center," said Peter Chapman, CEO & President of IonQ. "IonQ's hardware will serve as the backbone for quantum research. Our technology will play a critical role not only in the advancement of quantum, but also in fostering the next generation of quantum researchers and developers in South Korea."

"Our mission is to cultivate and promote the advancement of quantum information research in South Korea," said SKKU Professor of SAINT (SKKU Advanced Institute of NanoTechnology), Yonuk Chong. "We believe IonQ has the most advanced quantum technology available, and through our partnership, we will be able to make tremendous strides in the advancement of the industry."

This alliance builds on IonQ's continued success. IonQ recently released a product roadmap to deploy rack mounted quantum computers by 2023, and achieve broad quantum advantage by 2025. IonQ also recently unveiled a new $5.5 million, 23,000 square foot Quantum Data Center in Maryland's Discovery District. IonQ has raised $84 million in funding to date, announcing new investment from Lockheed Martin, Robert Bosch Venture Capital GmbH (RBVC) and Cambium earlier this year. Previous investors include Samsung Electronics, Mubadala Capital, GV, Amazon, and NEA. The company's two co-founders were also recently named to the National Quantum Initiative Advisory Committee (NQIAC).

About IonQIonQ is the leader in quantum computing. By making our quantum hardware accessible through the cloud, we're empowering millions of organizations and developers to build new applications to solve the world's most complex problems in business, and across society. IonQ's unique approach to quantum computing is to start with nature: using individual atoms as the heart of our quantum processing units. We levitate them in space with electric potentials applied to semiconductor-defined electrodes on a chip, and then use lasers to do everything from initial preparation to final readout and the quantum gate operations in between. The unique IonQ architecture of random-access processing of qubits in a fully connected and modular architecture will allow unlimited scaling. The IonQ approach requires atomic physics, precision optical and mechanical engineering, and fine-grained firmware control over a variety of components. Leveraging this approach, IonQ provides both a viable technological roadmap to scale and the flexibility necessary to explore a wide range of application spaces in the near term. IonQ was founded in 2015 by Jungsang Kim and Christopher Monroe and their systems are based on foundational research at The University of Maryland and Duke University.

About SKKUSungkyunkwan University (SKKU) is a leading research university located in Seoul, South Korea. SKKU is known around the world for the quality of its research and invests heavily in research and development. SKKU has more than 600 years of history as a leading educational institution, and is guided by the founding principles of benevolence, righteousness, propriety, wisdom, and self-cultivation.

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https://ionq.com

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IonQ and South Korea's Q Center Announce Three-Year Quantum Alliance - PRNewswire

Securing the DNS in a Post-Quantum World: Hash-Based Signatures and Synthesized Zone Signing Keys – CircleID

This is the fifth in a multi-part series on cryptography and the Domain Name System (DNS).

In my last article, I described efforts underway to standardize new cryptographic algorithms that are designed to be less vulnerable to potential future advances in quantum computing. I also reviewed operational challenges to be considered when adding new algorithms to the DNS Security Extensions (DNSSEC).

In this post, I'll look at hash-based signatures, a family of post-quantum algorithms that could be a good match for DNSSEC from the perspective of infrastructure stability.

I'll also describe Verisign Labs research into a new concept called synthesized zone signing keys that could mitigate the impact of the large signature size for hash-based signatures, while still maintaining this family's protections against quantum computing.

(Caveat: The concepts reviewed in this post are part of Verisign's long-term research program and do not necessarily represent Verisign's plans or positions on new products or services. Concepts developed in our research program may be subject to U.S. and/or international patents and/or patent applications.)

The DNS community's root key signing key (KSK) rollover illustrates how complicated a change to DNSSEC infrastructure can be. Although successfully accomplished, this change was delayed by ICANN to ensure that enough resolvers had the public key required to validate signatures generated with the new root KSK private key.

Now imagine the complications if the DNS community also had to ensure that enough resolvers not only had a new key but also had a brand-new algorithm.

Imagine further what might happen if a weakness in this new algorithm were to be found after it was deployed. While there are procedures for emergency key rollovers, emergency algorithm rollovers would be more complicated, and perhaps controversial as well if a clear successor algorithm were not available.

I'm not suggesting that any of the post-quantum algorithms that might be standardized by NIST will be found to have a weakness. But confidence in cryptographic algorithms can be gained and lost over many years, sometimes decades.

From the perspective of infrastructure stability, therefore, it may make sense for DNSSEC to have a backup post-quantum algorithm built in from the start one for which cryptographers already have significant confidence and experience. This algorithm might not be as efficient as other candidates, but there is less of a chance that it would ever need to be changed. This means that the more efficient candidates could be deployed in DNSSEC with the confidence that they have a stable fallback. It's also important to keep in mind that the prospect of quantum computing is not the only reason system developers need to be considering new algorithms from time to time. As public-key cryptography pioneer Martin Hellman wisely cautioned, new classical (non-quantum) attacks could also emerge, whether or not a quantum computer is realized.

The 1970s were a foundational time for public-key cryptography, producing not only the RSA algorithm and the Diffie-Hellman algorithm (which also provided the basic model for elliptic curve cryptography), but also hash-based signatures, invented in 1979 by another public-key cryptography founder, Ralph Merkle.

Hash-based signatures are interesting because their security depends only on the security of an underlying hash function.

It turns out that hash functions, as a concept, hold up very well against quantum computing advances much better than currently established public-key algorithms do.

This means that Merkle's hash-based signatures, now more than 40 years old, can rightly be considered the oldest post-quantum digital signature algorithm.

If it turns out that an individual hash function doesn't hold up whether against a quantum computer or a classical computer then the hash function itself can be replaced, as cryptographers have been doing for years. That will likely be easier than changing to an entirely different post-quantum algorithm, especially one that involves very different concepts.

The conceptual stability of hash-based signatures is a reason that interoperable specifications are already being developed for variants of Merkle's original algorithm. Two approaches are described in RFC 8391, "XMSS: eXtended Merkle Signature Scheme" and RFC 8554, "Leighton-Micali Hash-Based Signatures." Another approach, SPHINCS+, is an alternate in NIST's post-quantum project.

Figure 1. Conventional DNSSEC signatures. DNS records are signed with the ZSK private key, and are thereby "chained" to the ZSK public key. The digital signatures may be hash-based signatures.

Hash-based signatures can potentially be applied to any part of the DNSSEC trust chain. For example, in Figure 1, the DNS record sets can be signed with a zone signing key (ZSK) that employs a hash-based signature algorithm.

The main challenge with hash-based signatures is that the signature size is large, on the order of tens or even hundreds of thousands of bits. This is perhaps why they haven't seen significant adoption in security protocols over the past four decades.

Verisign Labs has been exploring how to mitigate the size impact of hash-based signatures on DNSSEC, while still basing security on hash functions only in the interest of stable post-quantum protections.

One of the ideas we've come up with uses another of Merkle's foundational contributions: Merkle trees.

Merkle trees authenticate multiple records by hashing them together in a tree structure. The records are the "leaves" of the tree. Pairs of leaves are hashed together to form a branch, then pairs of branches are hashed together to form a larger branch, and so on. The hash of the largest branches is the tree's "root." (This is a data-structure root, unrelated to the DNS root.)

Each individual leaf of a Merkle tree can be authenticated by retracing the "path" from the leaf to the root. The path consists of the hashes of each of the adjacent branches encountered along the way.

Authentication paths can be much shorter than typical hash-based signatures. For instance, with a tree depth of 20 and a 256-bit hash value, the authentication path for a leaf would only be 5,120 bits long, yet a single tree could authenticate more than a million leaves.

Figure 2. DNSSEC signatures following the synthesized ZSK approach proposed here. DNS records are hashed together into a Merkle tree. The root of the Merkle tree is published as the ZSK, and the authentication path through the Merkle tree is the record's signature.

Returning to the example above, suppose that instead of signing each DNS record set with a hash-based signature, each record set were considered a leaf of a Merkle tree. Suppose further that the root of this tree were to be published as the ZSK public key (see Figure 2). The authentication path to the leaf could then serve as the record set's signature.

The validation logic at a resolver would be the same as in ordinary DNSSEC:

The only difference on the resolver's side would be that signature validation would involve retracing the authentication path to the ZSK public key, rather than a conventional signature validation operation.

The ZSK public key produced by the Merkle tree approach would be a "synthesized" public key, in that it is obtained from the records being signed. This is noteworthy from a cryptographer's perspective, because the public key wouldn't have a corresponding private key, yet the DNS records would still, in effect, be "signed by the ZSK!"

In this type of DNSSEC implementation, the Merkle tree approach only applies to the ZSK level. Hash-based signatures would still be applied at the KSK level, although their overhead would now be "amortized" across all records in the zone.

In addition, each new ZSK would need to be signed "on demand," rather than in advance, as in current operational practice.

This leads to tradeoffs, such as how many changes to accumulate before constructing and publishing a new tree. Fewer changes and the tree will be available sooner. More changes and the tree will be larger, so the per-record overhead of the signatures at the KSK level will be lower.

My last few posts have discussed cryptographic techniques that could potentially be applied to the DNS in the long term or that might not even be applied at all. In my next post, I'll return to more conventional subjects, and explain how Verisign sees cryptography fitting into the DNS today, as well as some important non-cryptographic techniques that are part of our vision for a secure, stable and resilient DNS.

Read the previous posts in this six-part blog series:

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Securing the DNS in a Post-Quantum World: Hash-Based Signatures and Synthesized Zone Signing Keys - CircleID

SpaceX is about to run its final test of Starship SN9 before 1st launch – Livescience.com

SpaceX is gearing up to test the ninth prototype of its big, shiny rocket, Starship SN9 Wednesday (Jan. 20), lighting up its engines for what should be the last time before its inaugural flight. The test is expected before 5 p.m. Central Time.

The rocket won't go anywhere during this "static fire" test. (Or, at least, it's not supposed to.) But if all goes according to plan, this test should clear the way for a launch in the near future, though SpaceX has not set a date. NASA Spaceflight is livestreaming the test from the Boca Chica, Texas, site where SpaceX builds and tests its Starships.

Related: Here's every spaceship that's ever carried an astronaut into orbit

This will be the second static fire test of SN9, after a trio of Jan. 13 tests ended inconclusively, with the engines not firing for the full intended duration, as NASA Spaceflight reported. The company has since swapped out the engines used in the past tests.

Starship is SpaceX's moonshot literally. The company has suggested the 160-foot-tall (49 meters) and 30-foot-wide (9 m) vehicle could one day land large groups of people on the moon or Mars. It has also sold tickets to board a future Starship for an orbit around the moon. To do all that will require a far-larger "Super Heavy" booster rocket to loft Starship into space, and that rocket has not yet been built.

For now, SpaceX is focused on developing the Starship vehicle itself. The last prototype, SN8, demonstrated impressive capabilities during a December 2020 test flight. That test saw SN8 loft to the cruising altitude of a jetliner and make a controlled approach to its landing site before exploding on contact, as LiveScience reported at the time. SpaceX hasnt said what its goals are for this next launch, though a successful landing of the mammoth vehicle could be on the menu.

Originally published on Live Science

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SpaceX is about to run its final test of Starship SN9 before 1st launch - Livescience.com

Marques Brownlee details his business as a tech YouTuber and how he makes money on the platform – Business Insider India

Marques Brownlee was saving up his allowance money in high school when he decided to launch a YouTube channel.

The money he was saving up would help him buy a new laptop, where he could film and edit videos.

To help run the day-to-day of his creator business, Brownlee signed with the talent agency WME, and he has a small team of motion graphics artists, cinematographers, and assistants.

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"Oh, this is the number one holiday family reunion question," Brownlee told Nilay Patel in a recent episode of The Verge's podcast "Decoder."

For most YouTubers, their main source of revenue comes from the ads placed in their videos by Google.

"So, YouTube ads is the primary, fundamental way that YouTubers make money," Brownlee said on the Verge podcast. "You upload a video, there's ads somewhere on it or in it, and the YouTuber gets paid for the placement of those ads because they brought the eyeballs to the video."

Here is a breakdown of the main ways Brownlee makes money as a creator:

Creators who are part of YouTube's Partner Program are able to make money from their YouTube channels by placing ads within a video. These ads are filtered through Google's AdSense program.

Brownlee said on the Verge podcast that he also earns money by promoting brands in his YouTube videos.

"I negotiate the rate," Brownlee said on the Verge podcast. "The contract is usually built by my agent. I work with WME. And so, their lawyers will look over the contract and negotiate the terms, so I'm not literally reading the contracts. That's an arm I chopped off. I used to do that, too. They take their cut, obviously, for also bringing some of those contracts and companies to my inbox. But at the end of the day, if you could see the amount of stuff we say no to - it's just like a constant flow of, 'We want to be on the channel. We want to be in a video' - to find the stuff that really makes sense. And then, that's just me going, 'Let's see how we can make this work best.'"

But influencers don't have to run their own merch operation to take advantage of the business opportunity. Many, like Brownlee, partner with a company (he sells merch through the site Cotton Bureau.)

"For example, we have a merch store. You can buy apparel that has our cool designs on it," Brownlee said on the Verge podcast.

Read more: The top 7 merchandise companies helping creators on YouTube, Instagram, and TikTok earn money without relying on ads

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Marques Brownlee details his business as a tech YouTuber and how he makes money on the platform - Business Insider India

Here’s what former first ladies wore on Joe Biden’s Inauguration Day, from stylish jackets to symbolic suits – Business Insider India

Today's inauguration might have been all about Joe Biden and Kamala Harris, but some former first ladies almost stole the show with their fashion.

Michelle Obama and Hillary Clinton both arrived at the event wearing purple and burgundy ensembles that were packed with symbolism. Laura Bush, on the other hand, mirrored Jill Biden's fashion in a baby-blue coat. Melania Trump also made a bold fashion statement on Wednesday, despite not attending the event.

She wore the ensemble while departing the White House sans face mask. The former first lady and her husband did not attend Biden's inauguration.

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Like other first ladies who attended Biden's inauguration, Obama's outfit was majorly symbolic. Not only was it designed by Sergio Hudson, a Black fashion designer who she's worked with in the past, as reported by The Cut, but its purple-hued shade is also representative of bipartisanship and women's suffrage.

She wore a gray dress underneath a baby-blue coat, which she closed with only one button. The former first lady also wore sheer tights, black flats, a gray face mask, and shining pearls.

The outfit's color scheme resembled the blue ensemble worn by Jill Biden at the same event.

Clinton has worn purple to make a statement in the past. In 2017, she and her husband Bill Clinton both wore purple as a sign of bipartisanship after Donald Trump won the presidential election.

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Here's what former first ladies wore on Joe Biden's Inauguration Day, from stylish jackets to symbolic suits - Business Insider India

Confederate relics still standing at many Texas universities – The Texas Tribune

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This summer, students called on the University of Texas at Austin to stop playing the The Eyes of Texas, the alma mater song that has historical minstrel show ties. Aggies petitioned Texas A&M University to take down the statue of Lawrence Sullivan Sul Ross, a former governor and Confederate general. Students at Rice University demanded removal of the monument of the school founder, William Willy Rice, a slave owner.

This wasnt the first time Texas universities had faced these pressures. But as students joined protests across the nation condemning the police killings of George Floyd and Breonna Taylor and called for an end to racial injustice, they turned to their university leaders to address those ills on campus. School officials pledged to act.

But eight months later, the song is still playing at UT-Austin. Statues of Confederate leaders and segregationists still watch over Texas campuses. And many students of color feel most of their demands have been ignored or intentionally mired in lengthy, bureaucratic processes intended to delay answers to difficult questions.

The fact that its taking so long is disheartening, said Kendall Vining, a Rice junior, who co-wrote a list of 19 ways administrators could create a campus more inclusive for Black students. It means that, of course, somebody else is still trying to decide what's best for us, rather than us literally telling them what could be done to help.

While Texas campuses are implementing some significant changes like diversity training, increased scholarships for students of color, new curriculum on racial inequity and more recruitment for diverse faculties many students said the efforts dont directly address their demands or go far enough to dismantle the legacy of white supremacy on their campuses. Black students, who remain underrepresented on most large college campuses in the state, said the buildings and statues that remain serve as a reminder that they attend schools that werent intended to serve them.

When we have people who dont know what it feels like to be oppressed try to make decisions about the oppressed, they often overlook the real demands and they only see racism from their narrow point of view, said Qynetta Caston, a student at Texas A&M where just 3% of students are Black.

University leaders admit there is much work to be done, and insist they remain committed to change. In June and July, university leaders announced a variety of new initiatives aimed at correcting long-standing, institutional wrongs on campus. For example, the Texas A&M System approved $100 million in scholarship funding to boost diversity at all 11 campuses, and the University of North Texas launched a mandatory cultural competency training for all new students starting this fall. Texas A&M University-Commerce partnered with the George Floyd Foundation to start a new internship program for Black male students.

Yet Black students across the state grew frustrated as school officials relegated some of the hardest questions to newly assembled diversity committees. They worry universities are using committees to stall until outspoken students graduate.

But school leaders argue broad, cultural change takes time.

Theres always a desire to move faster and do it better, said Joe Carpenter, a spokesperson for the University of Texas at Arlington, where students were asking administrators to increase faculty of color and rename multiple buildings even before Floyds death. Some things, to be done right, take the involvement, not of one individual to just dictate something. Some of these initiatives aren't going to be successful if they're the idea of one person or if they are implemented by one person.

Its like the administration really believes that white supremacy is a reformable thing, rather than something that needs to be completely wiped away.

As cities across America watched protests fill the streets, dozens of universities removed statues and renamed campus buildings named for people with racist histories.

The University of Mississippi moved a statue out of the main building to a campus cemetery. The University of Alabama removed plaques honoring students who fought for the Confederate Army. In Las Vegas, the University of Nevada took down a statue of their Rebel mascot. Princeton University renamed colleges named after former President Woodrow Wilson due to his racist beliefs. Louisiana State University took the name of a former school president off its library because he advocated for segregation.

But Texas universities have largely dodged demands to remove historical reminders countering with committees vowing to study the issue and other offerings to improve diversity.

Its like the administration really believes that white supremacy is a reformable thing, rather than something that needs to be completely wiped away, said Shifa Rahman, a Rice University junior who organized sit-ins at the statue of Willy Rice. Rice set aside money before he died that helped establish the school in 1912 with the specific goal of serving white Texans.

A group of students at Rice have participated in the sit-ins nearly every evening since Aug. 31.

Rahman said administrators cant expect students to study among symbols of people who promoted white supremacy and still build an equitable campus. These symbols need to be abolished, he said.

Students at Rice dont just want the statue removed. A list of demands also included more Black faculty and improved lighting for Rice identification photos so students with dark skin are properly photographed.

In 2019, Rice launched a task force to explore the universitys historical connections to slavery, segregation and racial injustice, but has not released a report yet. President David Leebron said in an email to The Texas Tribune that they expected this work to take between two and four years. He also said they recently added a group to the task force who will discuss buildings and statues on campus, including the Willy Rice statue.

We have repeatedly said that the statue issue would be addressed after the task force finishes its initial report and we have all the information and all the varied opinions essential to making the right decision, Leebron said. As you might expect, there is a wide range of opinions on the statue and various alternatives have been suggested for addressing the history behind it, which is why its important to approach this issue thoughtfully.

In the meantime, Rice, where 5% of students are Black, announced a new diversity training and is piloting a diversity course this spring. Rice also hired its first vice provost for diversity, equity and inclusion.

Texas students agitating for change said their patience is wearing thin.

For every action that the university takes, there has to be like a committee, and then another committee to verify that committee and were just like in the cycle of committees, said Alcess Nonot, a senior at UT-Austin and president of the UT Senate of College Councils.

UT-Austin administrators pledged to review the schools diversity and inclusion action plan in the wake of the summer protests. The university had already taken down multiple Confederate statues in 2017, which resulted in at least one lawsuit that the university won. They also launched a new committee to study the history of the schools alma mater song, The Eyes of Texas, after students asked the university to stop singing it. The song premiered at a minstrel show in the early 1900s and the phrase Eyes of Texas was taken indirectly from comments Gen. Robert E. Lee used to make to students when he became a college president that the eyes of the South are upon you.

The University of Texas at Arlington, Baylor University, the University of Houston and Texas A&M University all similarly launched diversity committees.

Former Texas A&M President Michael Young set an Oct. 30 deadline for a final report with recommendations to improve race relations, diversity and address historical representations on campus, specifically the Sul Ross statue. Almost three months later, the committee has still not released a report.

A spokesperson said once the committee started meeting they realized it would take longer to delve into the issues and did not want to rush the process. However, system President John Sharp said in August, citing an attorney general opinion, the statue could only be moved by an act of the Legislature. Sharp said in a 2018 letter to the Aggie student newspaper that the statue would be on campus "forever" because Ross deserved to be honored for his service to the university.

At Baylor, university leaders launched a new scholarship program and created a new diversity training video, though it was largely panned by students and the Baylor Lariat student newspaper's editorial board as "missing the mark." A commission to review historical representations on campus, including statues of the three university founders, is expected to issue recommendations this spring.

Students like Lexy Bogney, a senior and president of the Baylor National Association for the Advancement of Colored People chapter, said they suspect these commissions and committees are used to placate alumni and donors that might disagree with student demands.

Even when [Baylor was] just saying, Black Lives Matter, you could see so many alumni on Twitter and Facebook, just saying, Why would you guys fall for this? Bogney said. I think this slow change is kind of coming from them trying to appease regents and alumni.

Indeed, alumni and donors at many Texas schools have been vocal in countering student demands for change, flooding university inboxes with threats to pull their money and even organizing counter protests, as they did at Texas A&M to support the Sul Ross statue.

In some cases, universities resistant to removing statues are erecting new ones honoring people of color. Texas A&M is building a statue of Matthew Gaines, one of the first Black state senators in Texas.

Students have been pushing for the Gaines statue since the 1990s, struggling to raise the necessary funds until last year. For Caston and other students, adding a statue of a Black man doesnt negate the presence of the Sul Ross statue.

Students echoed the same concern at Texas State University after the university announced it would rename two buildings on campus after distinguished alumni of color instead of renaming Flowers Hall, which is named after John Flowers, who defended segregation, and Beretta Hall, which is named after Sally Beretta, a Daughter of the Confederacy.

Until they actually acknowledge the real issues that they have helped create and maintain over the years, they can never be diverse and inclusive, said Evan Bookman, a senior who serves as the universitys NAACP chapter president.

A spokesperson for Texas State said the university will also name two previously unnamed streets at the campus north of Austin after distinguished alumni of color, too.

Questions about renaming Beretta and Flowers Halls have arisen in task force discussions, said spokesperson Jayme Blaschke, without answering additional questions. This will be an on-going inclusive conversation about complex issues that require collaboration and time to fully research.

UT-Austin, where just 5% of students are Black, is also erecting multiple new statues on campus rather than renaming buildings at the request of students. Theyre building a statue of the first group of Black undergraduate students, known as the Precursors, and built another of Julius Whittier, the first African-American letterman on the Longhorns football team.

UT-Austin was one of the only universities in the state that renamed a building in the wake of the summer protests. The Robert L. Moore Building became the Physics, Math and Astronomy Building. Moore was a decorated professor who opposed integration.

Still, students hoped the university would go farther. They had demanded that UT-Austin remove an additional statue and rename six more areas of campus including T.S. Painter Hall. Painter was the university president when Heman Sweatt sued after he was denied admission to UT Law School because he was Black, culminating in the Supreme Court case, Sweatt v. Painter. The university lost, allowing Sweatt to be the first Black person to attend UT Law School in 1950.

Instead of renaming Painter Hall, UT-Austin officials said they would name an entranceway to the building after Sweatt and create a space to honor Sweatt within the building.

It was actually kind of offensive, said Audra Collins, a computer science major at UT-Austin and president of the Association of Black Computer Scientists. To honor Heman Sweatt, you want to put a plaque or dedicate the entrance to the building of his oppressor?

UT-Austins Vice Provost for Diversity Edmund Gordon is leading the effort to honor Sweatt and said he understands the students perspective.

The notion that to just name an entrance after Sweatt within a building named after Painter is ironical, he said. But I would like to be able to continually demonstrate that irony rather than have it changed.

Gordon opposed previous decisions at UT-Austin to remove Confederate statues because he thinks it lets people forget the history and policies that have allowed Black students to remain underrepresented and underserved on campus.

He remembers when the UT System renamed a residence hall that was previously named for William Stewart Simkins, a former UT law professor who fought in the Confederacy and was a member of the Ku Klux Klan. The residence was named after Simkins in the 1950s to intimidate Black students after the Supreme Court decision that integrated schools.

If you ask students if they know what the name of [the residence hall] was before, its completely been erased from our memory, Gordon said. And I think thats a problem.

Students also wanted school leaders to address the impact of policing at their own universities. Those calls grew louder as students and activists across the country called for cities to defund police departments and reallocate money to other services.

Systemic racism [has] been developing for centuries. There are no magic wands to wave.

University of Houston graduate students demanded UH stop contracting with Houston police, citing police shootings among city officers there. They also called for anti-racism training for university officers. Other students said majority Black events are over-policed on campus.

Officials launched a slew of committees and work groups to examine UH policies, including policing and security.

University leaders are currently reviewing work group recommendations for possible approval, but no official changes have been made. Students criticized university leaders for not making more tangible changes, arguing there have been too many conversations about racial injustice without meaningful action. A spokesperson defended the universitys efforts.

Our work to confront racial injustice continues, and it remains a University priority, said UH spokesperson Shawn Lindsay. Systemic racism [has] been developing for centuries. There are no magic wands to wave.

Students said theyve watched universities act quickly in other instances.

Typically, if the school administration wants something done relatively quick, it takes a few strokes of a pen, and it's done, said Brian Kirksey, vice president of the Black Student Union This is something that's been an ongoing conversation for a few months now...It's definitely frustrating.

As students across Texas continue to push for change, Black students at Baylor University said they were reminded last semester that true inclusivity and equity will take more than removing statues and adding new scholarships.

This fall, the university would not allow a Black fraternity to show a video that broadly condemned police brutality in the nation as part of an annual family weekend talent show.

Administrators told students it was inappropriate for the intended audience, according to multiple students. Instead, school officials held a separate pre-recorded Zoom discussion about systemic racism on campus with students and faculty where the video was aired.

Inappropriate for the intended audience meant that Baylor did not want to exhibit a video concerning the daily life that we African Americans must live in every day to their intended audience of the white majority, the fraternity said in a statement on Instagram in September.

Baylor administrators defended their decision to move the video to another platform to the Tribune and said the video was viewed more than it would have been at the talent show, which people had to pay to access.

But Black students, who total 6% of student body, said administrators were still limiting when its appropriate to talk about race. The earlier statements from university leaders of support for Black lives over the summer started to ring hollow.

Clearly, that was just another learning opportunity for Baylor to see that they can't pick and choose when they want to stand on different platforms and what they support, said senior Mya Ellington-Williams.

Disclosure: Baylor University, Facebook, Rice University, Texas A&M University, the University of Texas at Arlington, the University of Texas at Austin, the University of Houston and the University of North Texas have been financial supporters of The Texas Tribune, a nonprofit, nonpartisan news organization that is funded in part by donations from members, foundations and corporate sponsors. Financial supporters play no role in the Tribune's journalism. Find a complete list of them here.

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Confederate relics still standing at many Texas universities - The Texas Tribune

Debate to remove the Confederate Monument outside of the Iredell County Government Center – Greensboro News & Record

The local chapter of the NAACP is hoping to remove this statue in front of Iredell County Government Center in downtown Statesville, N.C.

STAFF REPORT

The fight to remove the Confederate Monument outside of the Iredell County Government Center will continue into 2021 and it could be getting more interesting in the near future.

You said wait until next year after the election, Todd Scott said. Well, the election is over. If you choose not to vote, we will move forward with our plans to the national NAACP to increase their efforts and support to have it removed.

Scott, the president of the Statesville branch of the NAACP, issued that statement to the Iredell County Board of Commissioners during the public comment period on Tuesday night.

Weve been asking for them to do this for decades, Scott said. My mom died in 2019. She was 94, and she could remember talking about it long ago.

The statue, which has long been a target of the local NAACP, gained new notoriety last summer when the group Times4Change began protesting, asking for the statues removal from in front of the county government building.

However, despite the protests, there has been no progress toward a resolution.

That is why Scott is warning the commissioners about the potential of the national and state-level NAACP offices getting involved in the fight.

If I dont hear from (Chairman (James) Mallory) by Monday, Im going to my executive board, Scott said. If I go to them and say I think we should sue, they will pass it to the state and national levels for approval.

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Debate to remove the Confederate Monument outside of the Iredell County Government Center - Greensboro News & Record

Gwinnett County to vote today on removing Confederate monument in Lawrenceville – 11Alive.com WXIA

The vote is set to be held at 2 p.m.

LAWRENCEVILLE, Ga. Gwinnett County's board of commissioners will vote today on whether to remove a Confederate monument in Lawrenceville's city square.

The monument has been in place on the grounds of the historic county courthouse since the early 90s when the board of commissioners allowed the United Daughters of the Confederacy (UDC) to erect it there.

Over the last couple of years, it has been the subject of calls for removal numerous times, including by the Lawrenceville City Council, former Gwinnett District Attorney Danny Porter, and various civic groups and organizations.

Many of those calls were renewed this summer during the protests against racial injustice across the country, and with the removal or relocation of Confederate monuments in several cities.

A release sent out by one commissioner, Kirkland Carden, ahead of the vote called the monument "hateful and divisive."

An interfaith group who lobbied for its removal last year said it "glorifies a cause that brutalized the ancestors of many members of our community."

"While the recognition of fallen veterans is important, the placement of such a monument should be given careful consideration," the city council said in a statement last year. "As the City of Lawrenceville prepares to commemorate its bicentennial in 2021, it provides us a unique opportunity for reflection. Symbols and monuments are a tangible connection to our history, creating opportunities to remember our past and inform the ideals and actions that guide us in the present."

The monument itself is a broad stone slab, standing about five or six feet high with the inscription "1861-1865 Lest We Forget" on it.

On one side it says: "In remembrance of the citizens of Gwinnett County who honorably served the Confederate States of America." The other side includes a Winston Churchill quote that says in part "no nation can long survive without pride in its traditions."

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Gwinnett County to vote today on removing Confederate monument in Lawrenceville - 11Alive.com WXIA

Name of Virginias Camp Pendleton will be changed from that of Confederate general; new recommendation due next month – WAVY.com

VIRGINIA BEACH, Va. (WAVY) The process to rename Camp Pendleton a military base in Virginia named after a Confederate general is underway.

In a press conference in June, Gov. Ralph Northam said he supported renaming bases that carry Confederate names. After that, he directed his administration to review and recommend a replacement name for Camp Pendleton, which is in Virginia Beach, a governors office spokeswoman said.

A working group, which includes representatives from the Secretariat of Veterans and Defense Affairs and the Office of Diversity, Equity, and Inclusion, has been reviewing multiple names and will submit its recommendation to Northam by the end of February.

Renaming the Confederate bases from Northam was brought up during a press conference in June during which Northam urged Virginians to take Confederate statues down the right way. In July, legislation went into effect in Virginia allowing localities to remove, relocate or contextualize their Confederate monuments.

Just like the statues, these names are divisive, Northam said during the press conference.

The 2021 National Defense Authorization Act passed by Congress in December also included an amendment cosponsored by U.S. Sen. Tim Kaine (D-Va.) to rename other Department of Defense facilities that carry Confederate names.

The three bases impacted by that amendment in Virginia include Fort Lee, Fort Pickett, and Fort AP Hill. They will be renamed over a three-year process.

Do you really expect us to believe that a society that continues to honor those who tried to destroy our country to save slavery will be serious about ending the racial disparities that exist today? You either support the equality of all or you do not. And if you honor those who opposed our equality, indeed, opposed the very notion of our humanity, what hope can we have about overcoming the real time injustices that are manifest all around us? Kaine said in July.

Watch video of Kaines July 2020 floor speech on Confederate nameshere.

Get the free WAVY News App, available for download in the App Store and Google Play, to stay up to date with all your local news, weather and sports, live newscasts and other live events.

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Name of Virginias Camp Pendleton will be changed from that of Confederate general; new recommendation due next month - WAVY.com

Graham Selby: Here’s why the Confederate battle flag is offensive – Conway Daily Sun

The other day I was driving through Eaton and saw a Confederate flag flying prominently from someones home. It angered me seeing that, especially in light of the attack by white supremacists on our Capitol and parading the Confederate flag inside while someone used an American Flag to beat a police officer.

Why did it anger me? Because the Confederate flag is a symbol of racism. It does not represent a time in our history we should be glorifying. Racism is not, as many believe, hating some because of their color. It is believing that someone of a different color is inferior. Read this excerpt from a speech on March 21, 1861, by Alexander Stephens, vice president of the Confederate States:

They rested upon the assumption of the equality of races. This was an error ... Our new government is founded upon exactly the opposite idea; its foundations are laid, its corner-stone rests, upon the great truth that the negro is not equal to the white man; that slavery subordination to the superior race is his natural and normal condition ...

He goes on to say that it was God who created the races unequal. He also goes on to espouse many more offensive ideas. The name of the speech is the Cornerstone Speech where slavery is the cornerstone of the new government they proposed to establish. Now do you know why that flag is offensive?

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Graham Selby: Here's why the Confederate battle flag is offensive - Conway Daily Sun

Andy Schmookler: The issue of the Confederacy in America today – Northern Virginia Daily

The Civil War was a terrible bit of history, not least because it isnt just history. Its still with us.

The ongoing controversies over Confederate monuments and over schools being named after Confederate generals demonstrate that. As do the Confederate flags one sees flying in peoples yards, or pasted on their vehicles.

I sometimes wonder what the people who fly the Stars and Bars would say that flag expresses for them. From my years living in the Shenandoah Valley, what Id expect to hear is that they see the Confederate cause as expressing a noble and brave spirit, defiant of tyranny and defending of the cultures most basic values.

But whatever anyones intended meaning, that flag is also inescapably connected with the realities of history. Its a history centered on a war that got precipitated by the secession from the Union of the slave states in response to the election to the presidency of an anti-slavery candidate (Lincoln).

History makes it crystal clear that what that war was about was slavery.

Thats what the seceding states declared clearly during the months in which they committed themselves to fight that war rather than accept a government that opposed the expansion of slaverys domain into the new lands of the United States.

One of the Confederacys best leaders (its Vice President, Alexander Stephens) called it great moral truth that the white man is superior to the Black, and that the subordination of the Black to the white man is the Blacks natural and moral condition.

(Indeed, the history shows that the defense of slavery was the overriding purpose of practically every political effort the South made in the decades leading up to the Civil War from the war with Mexico to the transcontinental railroad to the Fugitive Slave Act and Dred Scott.)

The Fugitive Slave Act of 1850 suffices to show that the South had no principled concern with states rights. The notion that the South had some such noble cause was a lie that was concocted right after the war by the South (and that subsequent generations of southerners enforced as the official view of the war).

In addition, the Stars and Bars the flag of the rebels has consistently expressed a spirit of lawlessness:

The states that formed the Confederacy acted unconstitutionally when they unilaterally decided against the views of the president of the United States that they had the right to secede. Law obligated the South to assert in the Courts the rights it claimed.

Many in the South e.g. with the KKK acted lawlessly to overthrow Reconstruction and to terrorize the Blacks back into submission.

And this month, the mixture of Confederate flags with Trump banners among the lawless insurrectionists who overran the Capitol building and disrupted the peaceful transfer of power after a legitimate election suggests that same disrespect for the law is still connected with the persistent spirit of the Confederacy.

But those historic realities are not the way the people who nowadays fly the Stars and Bars and those who protest the renaming of schools see the Confederacy.

Seeing the Confederacy as heroic, they make heroes of Generals like Stonewall Jackson who fought for the noble cause of the slave power.

Hence the dilemma about the school names:

On the one hand, the historic truth shows reasons that is regrettable for a community to choose school names that declare the Confederacy at the heart of that communitys identity.

But on the other hand, changing the name of a school like Shenandoah Countys Stonewall Jackson High School comes up against the persistent reality that the spirit of the Confederacy albeit based on a false image still lives deep in the hearts and minds of a lot of people.

Whats the best way to deal with that dilemma particularly in an area where pro-Confederacy allegiance still predominates?

It is important to remember: what matters is the spirit that dwells in the culture. And that culture gets defined much more fundamentally by whats in the hearts and minds of the people than by mere names on buildings.

Clearly, just signaling a change that has not occurred i.e. taking the name of a Confederate general off a building doesnt move the culture in the desired direction.

Indeed, here in Shenandoah County, it has apparently done the opposite provoking a flare-up that reinforces the very sense of identification it would be desirable to change. A flare-up with hundreds of citizens feeling provoked to punish some fine public servants from the county School Board for their well-intentioned efforts to move the area toward a healthier relationship both with history, and with some important values.

What might have worked better to move hearts and minds?

Perhaps the establishment of a process of constructive conversation around the issues raised by question of renaming. A process structured to facilitate the issues being debated in a fashion that educates.

Instead of a decision, a proposal to discuss.

My sense is the fine educators on the Shenandoah County School Board would be capable of fostering such a discussion.

Whats needed for greater peace to replace the conflict that the Civil War still generates is education that enables the truth to gain ground against the lie.

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Andy Schmookler: The issue of the Confederacy in America today - Northern Virginia Daily

Letter to the editor: Honor Black citizens with grand counterpoint to Confederate monument – The Augusta Chronicle

Tennent Houston| Augusta

Augustas Confederate Monuments and Landmarks Task Force has recently made public its recommendations to the city government, one of which is the removal of the Confederate monumentfrom Broad Street. Mayor Hardie Davis is to be commended for approaching the volatile issue of historic structures and names in such a measured and reasonable manner.

But I think there is a much better solution than moving the existing monument. Instead, leave this statue in place but also erect an equally grand and prominent monument, perhaps on upper Broad Street, to the Black struggle for equality and to their contributions to our community and country.

We should note that while Springfield Village Park already recognizes the rich heritage of the historic church of that name and other Black citizens of Augusta, we lack a suitably prominent monument to recognize the magnitude of what Augustas Black citizens have suffered through the injustices of slavery, Jim Crow, segregation, discrimination and racism. Nor do we have an appropriate monument to recognize the importance of what they have contributed to our citys long history.

So why dont we work together to build a grand counterpoint to the Confederate memorial, perhaps on upper Broad Street, to honor our Black citizens? Would not these complementary bookends better reflect the hopes and aspirations of Augusta today? Wouldnt it be better for us all to work together constructively to make our city better? I believe that such an effort would enjoy such broad and enthusiastic support and would be an effort in which we could all take pride.

Tennent Houston, Augusta

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Letter to the editor: Honor Black citizens with grand counterpoint to Confederate monument - The Augusta Chronicle

Loyola Medicine Opens Neurology Clinic for COVID-19 Patients Living with Long-term Neurological and Cognitive Symptoms – Newswise

Newswise MAYWOOD, ILLoyola Medicine is providing multidisciplinary care for patients with long-term neurological, cognitive and other symptoms associated with COVID-19.

"While most patients with COVID-19 have mild-to-moderate symptoms and recover at home, a fraction of severe, typically hospitalized patients (approximately 10%, according to an article in the British Medical Journal) are discharged with lingering, life-altering symptoms," said Jos Biller, MD, professor and chair, department of neurology, Loyola University Medical Center and Loyola University Chicago Stritch School of Medicine. Dr. Biller is leading the Loyola Medicine COVID-19 neurology clinic.

Persistent neurological symptoms in patients following acute COVID-19 may include fatigue; brain fog; loss of smell (anosmia); distorted or loss of taste (dysgeusia); headache; vertigo; sleep disturbances; loss of muscle mass and strength (sarcopenia); and neuromuscular aches, cramps and pain (myalgia).

"These 'long-haul' patients may also have neuropsychiatric symptoms, including anxiety, depression and post-traumatic stress disorder," said Dr. Biller. "As a result of their symptoms, many of these individuals are unable to return to work and suffer economic stressors."

For older patients, COVID-19 may increase the risk for or exacerbate cognitive decline and dementia, said Dr. Biller, who co-authored the study, "Correlations between COVID-19 and burden of dementia" in the September 2020 Journal of the Neurological Sciences. "Many patients with dementia decline significantly after contracting COVID-19."

In addition to Dr. Biller, the Loyola COVID-19 neurology clinic includes neurologists Stasia Rouse, MD and Kathy Kujawa, MD, PhD. The clinic will refer patients to other specialists including psychiatrists, neuropsychologists, pulmonologists, cardiologists, gastroenterologists, nephrologists, and nutritionists as needed.

"The long-term symptoms of COVID-19 may be protracted," said Richard K. Freeman, MD, MBA, regional chief clinical officer, Loyola Medicine. "Loyola Medicine is committed to providing comprehensive, exemplary care to these patients."

For more information, please visit loyolamedicine.org or loyolamedicine.org/coronavirus.

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About Loyola MedicineLoyola Medicine, a member of Trinity Health, is a nationally ranked academic, quaternary care system based in Chicago's western suburbs. The three-hospital system includes Loyola University Medical Center, Gottlieb Memorial Hospital and MacNeal Hospital, as well as convenient locations offering primary care, specialty care and immediate care services from more than 1,800 physicians throughout Cook, Will and DuPage counties. Loyola is a 547-licensed-bed hospital in Maywood that includes the William G. & Mary A. Ryan Center for Heart & Vascular Medicine, the Cardinal Bernardin Cancer Center, a Level 1 trauma center, Illinois's largest burn center, a certified comprehensive stroke center and a childrens hospital. Loyola also trains the next generation of caregivers through its academic affiliation with Loyola University Chicagos Stritch School of Medicine and Marcella Niehoff School of Nursing. Gottlieb is a 247-licensed-bed community hospital in Melrose Park with the newly renovated Judd A. Weinberg Emergency Department, the Loyola Center for Metabolic Surgery and Bariatric Care and the Loyola Cancer Care & Research facility at the Marjorie G. Weinberg Cancer Center. MacNeal is a 374-licensed-bed teaching hospital in Berwyn with advanced medical, surgical and psychiatric services, acute rehabilitation, an inpatient skilled nursing facility and a 68-bed behavioral health program and community clinics. Loyola Medical Group, a team of primary and specialty care physicians, offers care at over 15 Chicago-area locations. For more information, visit loyolamedicine.org. You can also follow Loyola Medicine on LinkedIn, Facebook or Twitter.

About Trinity Health Trinity Health is one of the largest multi-institutional Catholic health care delivery systems in the nation, serving diverse communities that include more than 30 million people across 22 states. Trinity Health includes 92 hospitals, as well as100continuing care locations that include PACE programs, senior living facilities, and home care and hospice services. Its continuing care programs provide nearly 2.5 million visits annually. Based in Livonia, Mich., and with annual operating revenues of$18.8billion and assets of$30.5 billion, the organization returns$1.3billion to its communities annually in the form of charity care and other community benefit programs. Trinity Health employs about123,000colleagues, including6,800employed physicians and clinicians. Committed to those who are poor and underserved in its communities, Trinity Health is known for its focus on the country's aging population. As a single, unified ministry, the organization is the innovator of Senior Emergency Departments, the largest not-for-profit provider of home health care services ranked by number of visits in the nation, as well as the nations leading provider of PACE (Program of All Inclusive Care for the Elderly) based on the number of available programs. For more information, visit trinity-health.org. You can also follow Trinity Health on LinkedIn, Facebook or Twitter.

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Loyola Medicine Opens Neurology Clinic for COVID-19 Patients Living with Long-term Neurological and Cognitive Symptoms - Newswise

Effect of a passive hip exoskeleton on walking distance in neurological patients – DocWire News

This article was originally published here

Assist Technol. 2021 Jan 22. doi: 10.1080/10400435.2021.1880494. Online ahead of print.

ABSTRACT

Severe neurodegenerative diseases such as Parkinsons disease or multiple sclerosis and acute events like stroke, spinal cord injuries or other related pathologies have been shown to negatively impact the central and peripheral nervous systems, thus causing severe impairments to mobility. The development and utilisation of exoskeletons as rehabilitation devices has shown good potential for improving patients gait function. Ten older adults (age: 68.9 9.2 yrs; height: 1.65 0.08 m. mass: 71.6 11.0 kg) affected by neurological diseases impacting their gait function completed a 10-session gait training protocol where they walked for 10 minutes wearing a passive exoskeleton assisting hip flexion, namely Exoband. Results showed that participants walked a significantly longer distance in the last session of training with respect to the first session (453.1178.8m vs 392.4135.1m; respectively). This study indicates the potential of Exoband as an effective tool for gait rehabilitation in patients with neurological diseases. Wearable, lightweight and low-cost devices such as the one involved in this work have the potential to improve walking distance in patients.

PMID:33481693 | DOI:10.1080/10400435.2021.1880494

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Effect of a passive hip exoskeleton on walking distance in neurological patients - DocWire News

Beyond COVID-19, where will biopharma focus in 2021? – FierceBiotech

Fighting the pandemic will remain a top priority in 2021, not least for the biopharma companies working on the next generation of therapeutics and vaccines against COVID-19. But just because were in a pandemic doesnt mean all other diseases have stopped plaguing humanity. We asked executives which areas might see a resurgence this year, and neurology emerged as a popular horse to bet on.

Part of that interest could be down to Biogens once-failed Alzheimers disease candidate, aducanumab, which is slated for an FDA decision by March 7.

I think neurology will continue to be a big focus, at least in the first half of the year, while aducanumab is out there and all eyes are on the PDUFA, said Shehnaaz Suliman, M.D., president and chief operating officer of Alector, which is working on immuno-neurology approaches to neurodegenerative disease. There was a recent spate of high-priority deals done in the neuro spaceit signals appetite in Big Pharma and Big Biotech to do big value-creating deals.

RELATED: JPM: Alector, Annexon, Athira on what an aducanumab approval could mean for Alzheimer's R&D

Multiple executives agreed that aducanumab would not be a best-in-class drug but that its approval would give the whole field a boost, encouraging interest and investment in neurodegenerative disease R&D. Recent data for a similar drug, Eli Lillys donanemab, also offered hope.

I think its important to continue to go after neurology," said Doug Love, president and CEO of Annexon Biosciences. We are an aging population, and, of course, patients are going to have neurodegenerative disorders We need to think smart and branch out beyond Alzheimers. There are lots of neurodegenerative diseases. There are lots of kinds of dementia we can target.

Its a good time to pursue these indications, Love said, adding, As the field advances with various biomarkers, we will understand earlier in the disease process if drugs are working.

Another reason traditionally big indications like neurology and cardiology are getting more interest is the availability of genetic sequencing and the ability to slice those disease areas up into more manageable segments. It provides a regulatory path for companies working in those areas that previously did not exist, said Rahul Ballal, Ph.D., CEO of Imara, a company working on treatments for sickle cell disease and other blood disorders.

RELATED: JPM: Biogen bullish on Alzheimer's drug approval, sees Lilly data as positive despite AdComm rejection

For a long time, people have run away from those spaces for all the reasons you know: low probability of technical success, large, heterogeneous patient populations, Ballal said. And I think what biotech is doing thats really exciting within the neurodegenerative space and within cardiovascular disease is they are applying a rare disease approach to those diseases by finding patients within the very large swaths.

Whichever areas receive the most interest in 2021, the entire industry should make sure that treatments reach every patient who needs them, said Nessan Bermingham, CEO of Triplet Therapeutics.

We look at whats happening with the (COVID-19) vaccine and whats happening with the rollout of care for individuals who have gotten COVID-19, and the disparities are very clear, Bermingham said. In the U.S. and from a global standpoint, were only going to see those be further emphasized. This is something, as a biotech industry, we need to be very conscious of.

Biopharma companies should think about pricing, distribution and access not just of cutting-edge immuno-oncology meds and gene therapies but also of things like basic care, real-time feedback from doctors, diagnostics and imaging.

As we think about the disparities we face, weve not changed that, and arguably with new therapies coming out, weve actually made those disparities worse, Bermingham added. I think as an industry, we need to go back to the concept of healthcare democracy: that everyone has the right to healthcare.

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Beyond COVID-19, where will biopharma focus in 2021? - FierceBiotech

Examining the Association, Nature of Skin Disorders in Parkinson Disease – AJMC.com Managed Markets Network

AJMC: Hello, I'm Matthew Gavidia. Today on the MJH Life Sciences Medical World News, The American Journal of Managed Care is pleased to welcome Dr Nicki Niemann, neurologist at the Muhammad Ali Parkinson Center and an assistant professor of neurology at Barrow Neurological Institute. Dr Niemann additionally served as a co-author of a review article titled Parkinson's Disease and Skin.

Great to have you on, Nicki. Can you just introduce yourself and tell us a little bit about your work?

Dr Niemann: So, I'm a neurologist by training. I did my training at Baylor College of Medicine in Houston, Texas, and then I did my mood disorders fellowship with the same institution under the mentorship of Dr Joseph Jankovic, who's one of the co-authors on the review article that we're talking about today.

I'm originally from Denmark, where I was born and raised and where I went to medical school at the University of Copenhagen before relocating to first Texas and now here in Phoenix, Arizona, for work.

AJMC: To get us started, can you first speak on the association and nature of skin disorders in Parkinson disease

Dr Niemann: So, not to state the obvious necessarily, but PD is obviously quite a common condition. In fact, it's the second most common neurodegenerative condition after Alzheimer disease. We think of PD many times as a motor disorder because symptoms such as posture, resting tremor, and slowness are quite visible. But there's a whole array of very common and often problematic nonmotor symptoms. That includes not only depression, sleep disorders, constipation, loss of sense of smell, but also skin disorders. And the reason that PD presents with this broad range of symptoms is because it's not just a disorder of the brain itself. It's a multisystem disorder; it affects pretty much the whole body.

There are certain disorders that occur more common in PD than you would expect by chance. In terms of skin, this would be things like changes in sweating, seborrheic dermatitis, melanoma, something called bullous pemphigoid, rosacea, and other conditions. I think the main ones that seem to arise prior to PD are probably changes in sweating. We know that before someone presents with motor features of PD, they can have alterations of the autonomic nervous system, and that can lead to changes in sweat patterns.

Seborrheic dermatitis, which is another common condition that's characterized by redness, scaling, oiliness, sometimes burning pain in the seborrheic areas of the bodyso the scalp, the eyebrows, nasolabial folds, the chest sometimescan also in part be due to autonomic dysfunction, but likely also because of other things such as reduced facial expression or reduced facial movements, changes in hygiene, changes in lipid composition, and changes in the fungi that are on the skin.

Then there's another group of disorders that have perhaps more, or greater, morbidity and where the relationship is much more complex. The main one that people often think of in that regard is melanoma. We've known for several decades now that there is an increased risk of melanoma in PD. There was a recent paper that we referenced in our review article, which was a study done on North American populations in which the risk of melanoma seemed to be 2-and-a halffold greater for people with PD compared with those without.

The exact reason for the association is not completely established, but things like risk factors are shared between PD and melanoma. So, Caucasian race, fair skin, red hair, male gender, pesticide exposure, etc, all increase the risk of both PD and melanoma. There are genes that cause PD that are also found to be mutated in certain melanomasso there's that correlation. There are genes that control melanin synthesis that in parts are pigmentation that can affect your risk of melanomas, but also affect your risk of PD. And then there's also imaging features that are shared between PD and melanoma.

In particular, Im referring to the appearance of the midbrain, which is a structure that's involved in PD. When that structure is evaluated using ultrasound, a so-called hyperechogenic area can be visualized, and that can be seen in PD. It can be used as a biomarker of PD, but actually a lot of people with melanomas, even without PD, can also have similar imaging changes. So that's very interesting.

Lastly, on that note, I'll just mention that there have been reports and concerns, in the past primarily, that levodopa, which is the primary treatment for PD. might increase the risk of melanoma. The reason for that suspicion has been that levodopa is both a precursor to dopamine, which treats PD, but it's also a precursor to melanin, which is found in our skin and melanomas, etc. Several high-level studies, high-quality studies have firmly refuted that there's any association between use of levodopa and development of melanoma.

I won't go into much more detail, but there's also a couple other conditions that are a little bit less common, such as rosacea and bullous pemphigoid, that can also be seen more common in PD.

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Examining the Association, Nature of Skin Disorders in Parkinson Disease - AJMC.com Managed Markets Network

COVID-19s Effects on the Brain – The Scientist

When epidemics and pandemics washed over humanity through the ages, watchful doctors noticed that in addition to the usual, mostly respiratory ailments, the illnesses also seemed to trigger neurological symptoms. One British throat specialist observed in the late 1800s that influenza appeared to run up and down the nervous keyboard stirring up disorder and pain in different parts of the body with what almost seems malicious caprice. Indeed, some patients during the 188992 influenza pandemic reportedly became afflicted with psychoses, paranoia, stabbing pains, and nerve damage. Similarly, scholars have linked the 1918 flu pandemic to parkinsonism, neuropsychiatric disorders, and a broadly coinciding outbreak of the sleeping sickness encephalitis lethargica, which would often arrest patients in a coma-like statealthough researchers still debate whether the two are causally connected.

That SARS-CoV-2, the culprit of the COVID-19 pandemic, is also associated with neurological symptoms isnt entirely surprising, given some evidence that its close relatives, MERS-CoV and SARS-CoV-1, have been associated with neurological symptoms too. But the proportion of patients developing such symptomsand their mounting collective numbershas startled some scientists. When the news broke early last year that some 36 percent of COVID-19 patients in Wuhan hospitals were developing impaired consciousness, seizures, sensory impairments, and other neurological symptoms, that floored me, remarks Shibani Mukerji, a neuroinfectious disease specialist at Massachusetts General Hospital.

Autopsy studies have revealed a range of recurrent neuropathological features in hospitalized COVID-19 patients.

Now, entire clinics are being created specializing in subsets of patients with neurological symptoms, including one in London co-led by Patricia McNamara, a neurologist at the National Hospital for Neurology and Neurosurgery. She broadly separates neurological symptoms into two diverse groups. The firstdescribed in several reports last yearcomprises acute symptoms often afflicting hospitalized patients with severe disease. These can manifest as a confused, delirious state known as encephalopathy, or as strokes, peripheral nerve damage, or encephalitis, an inflammation of the brain. The second group represents long-term symptoms usually following milder infections, ranging from headaches, fatigue, sensations of numbness or tingling, and cognitive difficulties to occasionally seizures and inflammation of the heart, McNamara says. The people Ive seen so far [in this group] are people who slowly improve, but its certainly a very slow improvement.

As this cohort grows, so too does the global effort to investigate how SARS-CoV-2 causes such symptoms. The picture so far remains somewhat puzzling. Autopsy studieswhich have been limitedhave found clear signs of damage in dozens of brains of COVID-19 patients. Although traces of the virus have been reported in some brain specimens, in many cases it is nowhere to be found. While the question of whether SARS-CoV-2 directly infects the brain remains unresolved, researchers are exploring other mechanisms whereby it could affect the human brain.

I think all of us probably . . . would agree that there is no overwhelming infection of the brain, notes Avindra Nath, a neurovirologist at the National Institute of Neurological Disorders and Stroke. If there is, its a very, very miniscule amount. That cannot explain the pathology that we see. It has to be something more than that.

An electron microscope image depicting a section of a ciliated cell in a COVID-19 patients olfactory mucosa, where researchers found intact SARS-CoV-2 particles (stained in red) inside cells

Michael Laue/RKI & Carsten Dittmayer/Charit

Early in the pandemic, some researchers worried that SARS-CoV-2 could be gaining access to the brain and represent a neurotropic virus, McNamara says. That would offer an obvious hypothesis for some of the neurological symptoms observed, while also posing complex questions around how to therapeutically target pathological processes in the brain. And after all, the genetic material of SARS-CoV-1 and MERS-CoV have been spotted inside human brains, and even common cold-causing coronavirus proteins arecuriously, given that they rarely lead to neurological symptomscommon in autopsied brains, adds Helena Radbruch, a neuropathologist at the Charit hospital in Berlin.

Yet the first brain autopsies of COVID-19 patients didnt find much SARS-CoV-2 RNA, let alone viral protein. In a September study of 18 COVID-19 patients with neurological symptoms who died in hospitals last April, Mukerji and her colleagues found very low levels of RNAthe source of which is a mysteryin only five of the patient brains, and no signs of viral protein. Because the low RNA concentration seems out of proportion to the profound deficits that people are experiencing, she says, Id be extremely surprised [if] the majority of cases where people are having neurological symptoms are due to direct viral invasion.

By the time COVID-19 patients die, most virus in the lung has often already been cleared, and that might be the case for the brain too.

In a more recent postmortem analysis of 18 patients published in the New England Journal of Medicine, Nath and his colleagues couldnt find any evidence of the virus in the brain. However, an earlier study from researchers in Germany reported viral protein in the cranial nerves and isolated brainstem cells in 21 of 40 patients examined postmortem. Viral protein that has somehow reached the central nervous system typically elicits an immune response, Mukerji notes, but its presence in the German study didnt correlate with the severity of neural inflammation the team observed.

Whatever viral protein is doing inside the brain, Radbruch and her colleagues assert that it is indeed finding its way there. In an autopsy study published in November in Nature Neuroscience, they propose that the virus could get into the brainstem through the nose. Based on detailed autopsy analyses from 33 COVID-19 patients, they discovered intact coronavirus particles in supporting cells of the olfactory mucosa at the roof of the nose, along with evidence of active replication in the tissue. Perhaps viral replication destroys those cells, and/or induces inflammation, which could help explain the frequent loss of taste and smell at the start of SARS-CoV-2 infections, notes Charit neuropathologist Frank Heppner, a coauthor of the study. The virus could then work its way into the olfactory bulb, a hub for processing sensory information, and via specific cranial nerves into the brain. Indeed, they observed evidence of viral RNA in these tissues as well as viral RNA and protein inside cells in the medulla oblongata in the brainstem, and in other structures such as the cerebellum, hinting that the virus could be using multiple routes of entry into the brain.

Nevertheless, Radbruch and Heppner agree that the extent of SARS-CoV-2s infection pales in comparison to that of fellow RNA viruses such as rabies, which is devoted to infecting brain tissue. SARS-CoV-2 is more of an incidentally neurotropic virus, likely getting into the brain by accident, Heppner says. Notably, in the brainstem they only found viral protein inside endothelial cells that make up the lining of blood vesselsthe blood-brain barrierand not inside neurons. That could be due to difficulties detecting the virus inside neurons, or could indicate that it doesnt infect neurons. In contrast to endothelial cells, which have an abundance of ACE2, the molecular doorways SARS-CoV-2 uses to enter cells, neurons tend not to have ACE2 receptors.

Still, the jurys still out on whether SARS-CoV-2 infects the brain, notes Eric Song, an immunobiologist at Yale University who recently completed his PhD in immunologist Akiko Iwasakis lab there. He points to their recently published study on brain organoid models, which suggests that its possible for SARS-CoV-2 to infect and exert pathological effects in neural tissue. Plus, postmortem samples are limited in number, only show the final picture of a disease, and, by necessity, reflect what happens in just the sickest patients. By the time COVID-19 patients die, most virus in the lung has often already been cleared, and that might be the case for the brain too, Song says.

In a recent preprint, he and his colleagues couldnt find viral RNA in the brain-engulfing cerebrospinal fluid (CSF) of six living COVID-19 patients with neurological symptoms. But interestingly, they did find B cells and antibodies in the CSF, and not just ones that target SARS-CoV-2, but also ones that target the bodys own proteins, including components of neurons. What this finding means is unclear, but it adds to a string of findings of body-attacking immune machinery in COVID-19. The looming question now, Song says, is whether this is an enriched process in [COVID-19] or if its a process that occurs with the same magnitude in other viral diseases.

Magnetic resonance microscopy of the medulla in an autopsied COVID-19 patient. Yellow arrows indicate hypointense regions (dark areas that are possibly a sign of local bleeding) and red arrows signify hyperintense areas (bright patches sometimes indicating immune cell presence)

Myoung-Hwa Lee et al.

While the evidence of SARS-CoV-2 inside human brains remains murky, autopsy studies have revealed a range of recurrent neuropathological features in hospitalized COVID-19 patients. Pathologists have frequently found localized hypoxic damage caused by a lack of oxygen and associated infarcts (or ischemic strokes), and less commonly, signs of bleeding in the brain, as well as some inflammationin some cases a severe inflammation known as acute disseminated encephalomyelitis. What exactly causes these pathologies is unclear, but scientists have some suspicions about contributing factors.

For instance, blood clotswhich COVID-19 patients are prone to developcould create blockages that restrict blood supply to neural tissue, explaining the observed mini strokes, Song says. The difficulty in getting enough oxygen through damaged lungs probably also makes patients more vulnerable to hypoxic brain damage. Systemic hypoxia, in turn, could result in neurological symptoms, but in general, its hard to say how pathologies discovered in autopsies are connected to clinical symptoms observed in patients, Mukerji adds in an email, as neurological exams arent often conducted when patients are hospitalized.

The immune response to the virus could also explain some neurological complications. Perhaps the exuberant flush of proinflammatory cytokines in the bodys periphery could cause inflammatory cytokines within the brain to be more active and cause inflammation [there], McNamara suggests. Interestingly, the Charit neuropathologists recent paper also found signs of inflammation and hordes of highly activated microglial cellsbrain-resident immunological defendersthat could feasibly be the result of a local or peripheral immune overactivation, Heppner hypothesizes. In turn, this could perturb neuronal function, and help explain certain COVID-19 encephalopathy symptoms, such as agitation, confusion, excessive sleepiness, and comas. Some patients, for instance, have problems weaning from ventilationthey do not wake up, and so far, we do not really understand why, Radbruch says.

Curiously, some patients also exhibit signs of microscopic damage to the small blood vessels in their brains, as evidenced in Nath and his colleagues recent brain autopsy study. The SARS-CoV-2positive subjectswho were obtained from New York Citys chief medical examiners officerepresent a unique patient cohort, most of them having died suddenly. Some had been found dead in nursing homes or in the subway, Nath says. In 10 of 13 patient brains examined under a high-resolution MRI scanner, the team noticed patches that appeared unusually bright or darkthe latter likely signifying signs of bleeding. Scrutinizing those areas, which sometimes included the olfactory bulb, the team found evidence of damaged blood vessel walls. And wherever blood vessels were damaged, protein staining revealed leakage of fibrinogena blood coagulation protein whose presence in the brain is associated with various neurological disordersinto neural tissue. Clustering around those sites they found macrophages and sometimes also activated microglia and T cells.

A plausible hypothesis is that some of those immune cells attack the endothelial cells that line the blood vessels, a cell type that SARS-CoV-2 is known to infect. Naths study didnt find any evidence of that, but at least thats one way to explain it, he says. And maybe thats whats causing the leakage. Then once you get the fibrinogen in the brain, you can incite more inflammation there . . . so it keeps building up a spiral.

He and his team also discovered signs that shine light on the patients sudden deaths. Assuming the patients died of cardiac dysfunction, they examined the nuclei in the base of the brainstem involved in the control of breathing. There, they spotted macrophages clustering around those neurons, a possible sign of neuronophagia, in which phagocytes devour unhealthy neurons. These respiratory centers and some of these other brainstem nuclei are impaired in their function, Nath says. Its hard to say how generalizable these findings are among COVID-19 patients, but I think its quite possible that some of these long-term symptoms that people have may be related to some of these things. Along with other researchers, hes working on a series of studies in long hauler patients to find out.

Its unlikely that one mechanism of neurological effects will fit all patients. Finding out what causative processes are unfolding in individuals will require integrating different techniques and many more brain autopsies, of which there have been only around a few hundred reported so far, largely due to a shortage of specialized equipment and labs to conduct them, Nath says. It will also require some sorting of what is currently a hodgepodge of neurological symptomsfor example, by establishing diagnostic criteria of post-COVID-19 syndrome and defining what acute versus chronic symptoms are, Mukerji adds.

She says she hopes that these studies will also help those with neurological conditions caused by other infections. There are a variety of people whove had [viral] infections [such as] Ebola or West Nile, who have said that they have cognitive complaints, brain fog, and that theyre disabledand its largely fallen on some deaf ears, she says. I would be surprised if the world does not take up this discussion much more scientifically than it has done in the past [and] try to understand if we can develop . . . some sort of diagnostic, and then some sort of therapeutic agent to help what is now going to be a large percentage of the worlds population.

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COVID-19s Effects on the Brain - The Scientist

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How Will Global Polyphenols Resveratrol Phenolic Acids and Catechin Market React from 2021 Onwards? Reviewindependent - Reviewindependent